HP
MCID: EXT034
MIFTS: 65

Extrinsic Allergic Alveolitis (HP) malady

Respiratory diseases, Immune diseases categories

Summaries for Extrinsic Allergic Alveolitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

MalaCards: Extrinsic Allergic Alveolitis, also known as hypersensitivity pneumonitis, is related to sarcoidosis and allergic asthma. An important gene associated with Extrinsic Allergic Alveolitis is SFTPD (surfactant protein D), and among its related pathways are B cell receptor signaling pathway and Senescence and Autophagy. The compounds cycloheximide and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and monocytes, and related mouse phenotypes are vision/eye and nervous system.

Wikipedia:63 Hypersensitivity pneumonitis (HP; also called extrinsic allergic alveolitis, EAA) is an inflammation of... more...

Aliases & Classifications for Extrinsic Allergic Alveolitis

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8Disease Ontology, 48Orphanet, 60UMLS, 42NIH Rare Diseases, 44Novoseek, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
extrinsic allergic alveolitis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

extrinsic allergic alveolitis 8 48 60
hypersensitivity pneumonitis 8 42 48
alveolitis 8 44 60
extrinsic allergic pneumonia hypersensitivity pneumonitis 42
allergic interstitial pneumonitis 42
alveolitis, extrinsic allergic 42
pneumonitis hypersensitivity 44
allergic pneumonitis 42
hp 48


External Ids:

Disease Ontology8 DOID:841
ICD9CM27 495.9, 495
NCIt39 C34369
MeSH34 D000542
ICD10 via Orphanet26 J67.0, J67.2, J67.3 J67.4, J67.5, J67.6, J67.7, J67.8, J67.9, J67.1, more
SNOMED-CT via Orphanet57 37471005
UMLS via Orphanet61 C0002390
MESH via Orphanet35 D000542
ICD1025 J67, J67.8, J67.9

Related Diseases for Extrinsic Allergic Alveolitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Extrinsic Allergic Alveolitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 482)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoidosis31.1FCER2, IL1B, CD14, HLA-DRB1, TNF, ICAM1
2allergic asthma30.7FCER2, IL8, IL10, CD14, IGHE, ICAM1
3pulmonary fibrosis30.7TGFB1, IL1B, IL8, MPO, SOD1, SFTPD
4asthma30.7TGFB1, FCER2, IL1B, IL8, IL10, CD79A
5idiopathic pulmonary fibrosis30.6TGFB1, IL1B, IL8, SFTPD
6hypertension30.6TGFB1, ALB, CD79A, ICAM1
7pneumonia30.6TGFB1, IL6, IL1B, IL8, IL10, CXCL2
8celiac disease30.4CD79A
9aspergillosis30.4CD79A, SFTPD
10allergic bronchopulmonary aspergillosis30.4IGHE, SFTPD
11interstitial lung disease30.4TGFB1, IL8, SFTPD
12cork-handlers' disease30.4ALB, IL8, MPO, SOD2
13pulmonary sarcoidosis30.4TNF, ICAM1, SFTPD
14psoriatic arthritis30.4IL1B, HLA-DRB1, TNF
15arthritis30.4IL6, IL1B, IL8, TNF
16atherosclerosis30.3TGFB1, ALB, IL6, IL1B, IL8, IL10
17malaria30.2ALB, FCER2, IL10, HP, HLA-DRB1, TNF
18crohn's disease30.2ALB, TNF
19pulmonary tuberculosis30.2IL10, HP, CD14, HLA-DRB1
20plasmodium falciparum malaria30.2IL10, HP, HLA-DRB1, ICAM1
21type 1 diabetes30.2ALB, IL1B, CD79A, HLA-DRB1
22eosinophilia30.1FCER2, IL8, IL10, CD79A, CD14, IGHE
23sickle cell disease30.1HP
24hemochromatosis30.1HP
25acute poststreptococcal glomerulonephritis30.1CD79A
26hellp syndrome30.1HP
27hemoglobinuria30.1HP
28cholangitis30.1ALB
29autoimmune hemolytic anemia30.1HP, CD79A
30protein-energy malnutrition30.1ALB
31polymyalgia rheumatica30.1HLA-DRB1
32mastitis30.1ALB, IL1B, IL8, HP
33coronary artery disease30.1IL6, HP, CD14, ICAM1
34diabetic nephropathy30.1TGFB1, ALB, HP, SOD2
35ischemia30.1CXCL2, HP, CD14, MPO, ICAM1, SOD1
36hepatitis30.1TGFB1, ALB, HLA-DRB1
37liver cirrhosis30.1TGFB1, ALB, CD14, HLA-DRB1
38bronchiolitis obliterans30.0IL8
39bronchiolitis30.0FCER2, IL8, IGHE
40juvenile rheumatoid arthritis30.0IL6, HLA-DRB1, TNF
41diabetes mellitus30.0TGFB1, ALB, IL6, IL1B, HP, CD79A
42myositis30.0ICAM1
43purpura30.0CD79A
44pulmonary eosinophilia30.0IL8, IGHE, SFTPD
45multiple myeloma30.0IL6
46rheumatoid arthritis30.0FCER2, IL6, IL1B, IL8, IL10, HP
47colorectal cancer30.0TGFB1, CD14
48ovarian cancer30.0TGFB1, HP
49schizophrenia30.0CD14, HLA-DRB1
50lung cancer30.0TGFB1, ALB

Graphical network of the top 20 diseases related to Extrinsic Allergic Alveolitis:



Diseases related to extrinsic allergic alveolitis

Clinical Features for Extrinsic Allergic Alveolitis

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Drugs & Therapeutics for Extrinsic Allergic Alveolitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Extrinsic Allergic Alveolitis

Drug clinical trials:

Search ClinicalTrials for Extrinsic Allergic Alveolitis

Search NIH Clinical Center for Extrinsic Allergic Alveolitis

Search CenterWatch for Extrinsic Allergic Alveolitis

Genetic Tests for Extrinsic Allergic Alveolitis

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Anatomical Context for Extrinsic Allergic Alveolitis

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32MalaCards
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MalaCards organs/tissues related to Extrinsic Allergic Alveolitis:

32
Lung, Testes, Monocytes, Skin, Myeloid, Nk cells, T cells

Animal Models for Extrinsic Allergic Alveolitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Extrinsic Allergic Alveolitis:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.6SOD1, SOD2
2MP:00036319.5TGFB1, SOD1
3MP:00053699.3SOD1, ICAM1, TGFB1
4MP:00053859.0SOD2, SOD1, MPO, HP, IL10, IL1B
5MP:00053768.2SOD1, ICAM1, IGHE, CD14, CD79A, HP
6MP:00053817.6TGFB1, ALB, FCER2, IL6, IL10, TNF
7MP:00020067.6ICAM1, TNF, HP, IL10, IL1B, IL6
8MP:00053707.6SOD2, SOD1, TNF, HP, IL10, IL6
9MP:00053847.1SOD2, SOD1, ICAM1, TNF, CD79A, HP
10MP:00107686.2MPO, TNF, ICAM1, SOD1, SOD2, SFTPD
11MP:00053976.1MPO, TNF, ICAM1, SOD1, SOD2, SFTPD
12MP:00053875.6TGFB1, SFTPD, SOD2, SOD1, ICAM1, TNF

Publications for Extrinsic Allergic Alveolitis

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50PubMed
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Articles related to Extrinsic Allergic Alveolitis:

(show top 50)    (show all 158)
idTitleAuthorsYear
1
New occupational and environmental causes of asthma and extrinsic allergic alveolitis. (23153603)
2012
2
Surfactant protein A in chronic extrinsic allergic alveolitis. (22654012)
2012
3
Mortality trends in asbestosis, extrinsic allergic alveolitis and sarcoidosis in England and Wales. (21704503)
2011
4
Extrinsic allergic alveolitis with an atypical immune expression. (19280076)
2009
5
Extrinsic allergic alveolitis: comparative study of the bronchoalveolar lavage profiles and radiological presentation. (16954458)
2006
6
Extrinsic allergic alveolitis. (16635083)
2006
7
Production of soluble tumor necrosis factor receptors and tumor necrosis factor-alpha by alveolar macrophages in sarcoidosis and extrinsic allergic alveolitis. (15653992)
2005
8
Extrinsic allergic alveolitis caused by misting fountains. (15950134)
2005
9
Cockade-like structures in alveolar macrophages in extrinsic allergic alveolitis. (15753634)
2005
10
Respiratory syndrome very similar to extrinsic allergic alveolitis due to Penicillium verrucosum in workers in a cheese factory. (11307594)
2001
11
Sulfasalazine-induced extrinsic allergic alveolitis in a patient with psoriatic arthritis. (11726310)
2001
12
Extrinsic allergic alveolitis caused by cabreuva wood dust. (11031353)
2000
13
Mucosal immunity in extrinsic allergic alveolitis: salivary immunoglobulins and antibody against inhaled avian antigens among pigeon breeders. (10383597)
1999
14
BN 52021 decreases alveolar macrophage-mediated lung injury in experimental extrinsic allergic alveolitis. (10704058)
1999
15
Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates. (7751497)
1995
16
Soluble intercellular adhesion molecule-1 (ICAM-1) in sera and bronchoalveolar lavage (BAL) fluids of extrinsic allergic alveolitis. (7554406)
1995
17
Extrinsic allergic alveolitis and asthma in a sawmill worker: case report and review of the literature. (8130843)
1994
18
Expression of the adhesion molecule ICAM-1 on alveolar macrophages and in serum in extrinsic allergic alveolitis. (7903468)
1993
19
Increased expression of the monocyte differentiation antigen CD14 in extrinsic allergic alveolitis. (7510201)
1993
20
Extrinsic allergic alveolitis: problems in diagnosis and a potential use for computed tomography. (1615180)
1992
21
Extrinsic allergic alveolitis caused by goose feathers in a duvet. (1465764)
1992
22
Chronic extrinsic allergic alveolitis in a family with idiopathic pulmonary fibrosis: the importance of histological diagnosis. (1426227)
1992
23
Mimics of sarcoidosis. Extrinsic allergic alveolitis. (1670003)
1991
24
Clinical guidelines and indications for bronchoalveolar lavage (BAL): extrinsic allergic alveolitis. (2292296)
1990
25
Expression of the Fc-receptor for IgE (Fc epsilon RII, CD23) on alveolar macrophages in extrinsic allergic alveolitis. (2139100)
1990
26
Bird-fancier's lung: a case report of probable extrinsic allergic alveolitis in a pigeon-breeder. (2635406)
1989
27
Longitudinal course of extrinsic allergic alveolitis in pigeon breeders. (2763241)
1989
28
Extrinsic allergic alveolitis caused by spores of the oyster mushroom Pleurotus ostreatus. (3169217)
1988
29
Bronchoalveolar lavage in extrinsic allergic alveolitis. (3485301)
1986
30
Effect of cigarette smoking on the antibody response to inhaled antigens and the prevalence of extrinsic allergic alveolitis among pigeon breeders. (4053338)
1985
31
Antibody measurement in extrinsic allergic alveolitis. (6723835)
1984
32
Extrinsic allergic alveolitis in the tobacco industry. (6318802)
1984
33
Sporobolomyces: a possible cause of extrinsic allergic alveolitis. (6684133)
1983
34
Extrinsic allergic alveolitis. (6549942)
1983
35
Extrinsic allergic alveolitis. (6641278)
1983
36
Skin testing and extrinsic allergic alveolitis. (6616972)
1983
37
Extrinsic allergic alveolitis due to milk allergy: case report and review of the literature. (7065466)
1982
38
Splenic granulomas in Farmer's lund disease. An extrapulmonary manifestation of extrinsic allergic alveolitis. (7113755)
1982
39
Phospholipids and microviscosity study in broncho-alveolar lavage fluids from control subjects and from patients with extrinsic allergic alveolitis. (7285366)
1981
40
Protective value of dust respirators in extrinsic allergic alveolitis: clinical assessment using inhalation provocation tests. (7336370)
1981
41
An epidemic of extrinsic allergic alveolitis caused by tap water. (6988107)
1980
42
Clinical and immunological studies in pulmonary extrinsic allergic alveolitis. (Watson Prize Lecture, Royal College of Physicians and Surgeons, Glasgow, 4 April 1977). (152974)
1978
43
Extrinsic allergic alveolitis from bird exposure. Studies on the immediate hypersensitivity reaction. (563307)
1977
44
Extrinsic allergic alveolitis: a disease commoner in non-smokers. (594937)
1977
45
Editorial: Extrinsic allergic alveolitis. (1260333)
1976
46
Extrinsic allergic alveolitis. (1089312)
1975
47
Extrinsic allergic alveolitis due to rat serum proteins. (1053443)
1975
48
Experimental extrinsic allergic alveolitis induced in the guinea-pig with Streptomyces olivaceus. (4207504)
1974
49
Extrinsic allergic alveolitis, (hypersensitivity pneumonitis) (case report). (4521428)
1974
50
Irreversible lung damage in extrinsic allergic alveolitis from pigeon dust inhalation. (5463319)
1970

Genetic Variations for Extrinsic Allergic Alveolitis

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Expression for genes affiliated with Extrinsic Allergic Alveolitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Extrinsic Allergic Alveolitis

Search GEO for disease gene expression data for Extrinsic Allergic Alveolitis.

Pathways for genes affiliated with Extrinsic Allergic Alveolitis

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29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 53Reactome, 12EMD Millipore
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Pathways related to Extrinsic Allergic Alveolitis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2CD79A
210.2IL8
310.2IL1B
410.1SOD1
5
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10.1IL6
6
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10.0HLA-DRB1
79.9SOD1, SOD2
8
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9.7CXCL2
9
Hide members
9.6SOD2, SOD1, IL8
109.6IL6, IL8, CD14
119.5IL8, IL6, IL1B
129.5IGHE, FCER2, IL10
139.4ICAM1, HLA-DRB1, IL10
149.4IL1B, IL8, IL10, CD14
159.4CD14, IL8, MPO, IL6
169.4SFTPD, CD14, MPO, HLA-DRB1
179.2IL10, ICAM1, HLA-DRB1, FCER2
18
Hide members
9.2CD14, CXCL2, SOD2
199.2HLA-DRB1, CXCL2
209.1ICAM1, IL1B, MPO, TNF
21
Hide members
9.0CXCL2, TGFB1
229.0TNF, ICAM1, IL6, IL8
238.9CXCL2, IL1B, IL8, CD14
24
Hide members
8.8TNF, CD14, IL8, IL1B, IL6
25
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8.8IL8, IL1B, IL6, CD14, TNF
268.8IL6, ICAM1, TNF, MPO, HP
278.8IL1B, IL10, CD14, TNF, IL6
288.7IL1B, IL6, TNF, IL10, IL8
298.7IL6, IL10, IL8, IL1B, TNF
30
Cytokine production by Th17 cells in CF (Mouse model)
8.7IL8, TGFB1, IL6, CD14, ICAM1
318.7TNF, IL1B, IL6, ICAM1, IL10
32
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8.7IGHE, FCER2, CD79A, ICAM1, TNF
33
Immune response Bacterial infections in normal airways
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8.6SFTPD, TNF, IL8, IL1B, IL6, CD14
34
Development PDGF signaling via STATs and NF-kB
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8.5TNF, MPO, CD14, IL10, IL1B, IL6
35
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8.5TNF, HLA-DRB1, CD14, CD79A, FCER2, IL1B
36
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8.5IL6, IL1B, IL8, TNF, CD14, IL10
378.5CD14, IL1B, IL8, IL10, IL6, TNF
388.5CXCL2, IL8, IL6, IL1B, CD14
398.4FCER2, TNF, IL1B, CD14, HLA-DRB1, IL6
408.4IL10, TGFB1, CD14, TNF, HLA-DRB1
41
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8.4IL1B, IL10, IL6, TNF, TGFB1
42
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8.2HLA-DRB1, IL8, IL1B, IL6, TNF, ICAM1
43
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8.2TNF, IL6, IL1B, IL10, ICAM1, HLA-DRB1
44
Hide members
8.2CXCL2, IL8, TNF, IL6, IL1B
458.1CXCL2, IL1B, IL6, TNF, ICAM1
46
Hide members
8.0HLA-DRB1, IL6, IL1B, CD79A, CD14, IGHE
478.0IL8, IL1B, CXCL2, ICAM1, CD14, TNF
487.7IL1B, MPO, ALB, TNF, ICAM1, IL6
497.5IL1B, TNF, CXCL2, TGFB1, IL6, ICAM1
50
Hide members
7.3TGFB1, IL6, IL1B, IL8, IL10, TNF

Compounds for genes affiliated with Extrinsic Allergic Alveolitis

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Sources:
44Novoseek, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Extrinsic Allergic Alveolitis according to GeneCards/GeneDecks:

(show top 50)    (show all 253)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6SOD2
2pentoxifylline44 1111.4CD14, MPO
3ulinastatin4410.1ICAM1, MPO, HP
4ivig4410.0CD79A, IGHE
5hydrocortisone44 2 59 1112.8IL8, IGHE, FCER2
6endotoxin449.8CXCL2, ICAM1
7okt3449.6IL6, IL10, ICAM1, FCER2
8gm-csf44 2810.6ICAM1, TNF, CD14, IL10
9prednisolone44 28 1111.5SFTPD, MPO, IGHE, CD14, CD79A
10pge2449.4TGFB1, CXCL2
11cyclosporin a44 28 5911.3ICAM1, IGHE, CD14, CD79A, HP
12diphenyleneiodonium449.2SOD2, SOD1, MPO, IL1B, TGFB1
13allergens449.1FCER2, HLA-DRB1, IL10, IGHE, SFTPD
14taurine chloramine449.0IL6, IL1B, IL8, MPO, TNF
15mip 1alpha448.9TNF, IL6, IL8, IL10, IL1B
16gold sodium thiomalate448.9IL1B, IL8, CD14, HLA-DRB1, TNF
17lipoteichoic acid448.8CD14, IL8, IL1B, IL10, TNF, IL6
18pdtc448.8SOD2, SOD1, IL8, IL1B, IL6, TGFB1
19triptolide448.8CD14, TNF, IL8, IL1B, ICAM1, IL6
20sulfasalazine44 28 49 1111.7HP, IL8, IL1B, CD79A, MPO, TNF
21il-12448.7TNF, IL10, IL8, IL1B, IL6
22vitamin d448.7IL6, IGHE, CD14, CD79A, HP, IL10
23polymyxin b448.6TNF, CD14, IL8, IL1B, IL6, ICAM1
24peptidoglycan44 289.6IL10, CD14, IL1B, TNF, IL8, IL6
255 aminosalicylic acid448.6MPO, TNF, IL8, IL10, IL1B
26budesonide44 49 1110.5IGHE, IL8, IL1B, MPO, TNF, ICAM1
27methacholine44 119.4ICAM1, MPO, IGHE, CD14, CD79A, IL8
288-isoprostane448.3SOD1, ICAM1, TNF, MPO, HP, IL10
29il 10448.3IL6, TGFB1, IL1B, IL8, IL10, TNF
30creatinine448.2HP, ALB, TGFB1, CD79A, CD14, IGHE
31herbimycin a44 599.2CD14, FCER2, ICAM1, TNF, IL8, IL1B
32groalpha448.0IL6, IL1B, ICAM1, TNF, CXCL2, IL8
33neopterin447.9HP, IL10, IL8, IL1B, FCER2, CD79A
34ascorbic acid44 248.9IGHE, SOD2, MPO, ICAM1, HP, ALB
35ccl344 288.9TNF, IL6, IL1B, IL8, IL10, ICAM1
36tarc447.9IL8, IL10, CXCL2, TNF, IGHE, ICAM1
37calcitriol44 59 11 2410.7ALB, IL6, IL1B, IL10, CD14, TNF
38rantes447.6ICAM1, CD14, CXCL2, IL1B, IL6, TGFB1
39sp 60012544 598.5TNF, ICAM1, IL1B, IL6, TGFB1, IL8
40dexamethasone44 49 28 1110.5FCER2, SFTPD, SOD2, IGHE, CD14, CXCL2
41actinomycin d447.3SOD2, TNF, IGHE, HP, IL8, IL1B
42hyaluronic acid44 248.3IL6, ALB, TGFB1, IL1B, IL8, HP
43sb 20358044 598.1TGFB1, IL6, IL1B, IL8, IL10, CXCL2
44methotrexate44 49 119.0ALB, TGFB1, SOD2, TNF, HLA-DRB1, IGHE
45ly294002446.9TNF, TGFB1, IL6, IL8, IL10, CXCL2
46n acetylcysteine446.7ICAM1, TNF, MPO, IGHE, CD79A, CXCL2
47nitric oxide44 11 248.6FCER2, IL6, IL1B, IL8, IL10, CXCL2
48histamine44 28 248.2IL6, FCER2, ALB, TGFB1, IL1B, IL8
49vegf445.7IGHE, CD79A, HP, CXCL2, IL10, IL8
50lactate445.2MPO, SFTPD, SOD2, SOD1, TGFB1, ALB

GO Terms for genes affiliated with Extrinsic Allergic Alveolitis

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Sources:
16Gene Ontology
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Cellular components related to Extrinsic Allergic Alveolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.3TNF, HLA-DRB1, CD79A, IL6, FCER2, ICAM1
2extracellular spaceGO:0056155.2TGFB1, SFTPD, SOD1, ICAM1, TNF, MPO
3extracellular regionGO:0055765.2CD14, IGHE, TNF, SOD1, SFTPD, HP

Biological processes related to Extrinsic Allergic Alveolitis according to GeneCards/GeneDecks:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cytokine secretion involved in immune responseGO:00274010.5IL10
2response to superoxideGO:00030310.2SOD2, SOD1
3removal of superoxide radicalsGO:01943010.1SOD2, SOD1, MPO
4positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.1FCER2, TNF
5receptor biosynthetic processGO:03280010.0TNF, IL10
6positive regulation of calcidiol 1-monooxygenase activityGO:06055910.0TNF, IL1B
7response to hydrogen peroxideGO:04254210.0SOD2, SOD1, HP
8sequestering of triglycerideGO:03073010.0TNF, IL1B
9positive regulation of heterotypic cell-cell adhesionGO:03411610.0IL1B, TNF
10positive regulation of fever generationGO:03162210.0TNF, IL1B
11hydrogen peroxide biosynthetic processGO:05066510.0SOD1, SOD2
12response to heatGO:0094089.9SOD1, CD14, IL6
13positive regulation of cytokine secretionGO:0507159.9IL10, CD14, TNF
14response to activityGO:0148239.8SOD2, TNF, IL10
15negative regulation of growth of symbiont in hostGO:0441309.8IL10, MPO, TNF
16negative regulation of lipid storageGO:0108889.8IL6, TNF
17cellular response to lipopolysaccharideGO:0712229.8ICAM1, CD14, IL10, IL8
18epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.8IL6, TNF
19positive regulation of chemokine biosynthetic processGO:0450809.8IL1B, TNF
20positive regulation of superoxide anion generationGO:0329309.7TGFB1, SOD1
21positive regulation of interleukin-6 productionGO:0327559.6TNF, IL1B, IL6
22regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.6TNF, IL1B
23response to molecule of bacterial originGO:0022379.5IL8, IL10, CXCL2
24response to glucocorticoid stimulusGO:0513849.5TNF, IL10, IL6
25lipopolysaccharide-mediated signaling pathwayGO:0316639.4TGFB1, IL1B, TNF
26cellular response to organic cyclic compoundGO:0714079.4TNF, IL1B, TGFB1
27protein kinase B signaling cascadeGO:0434919.4TGFB1, IL1B, TNF
28positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4TNF, IL10, IL1B, IL6
29negative regulation of T cell proliferationGO:0421309.4TGFB1, IL10, HLA-DRB1, SFTPD
30MAPK cascadeGO:0001659.3TGFB1, IL1B, TNF
31positive regulation of peptidyl-serine phosphorylationGO:0331389.3TNF, IL6, TGFB1
32cytokine-mediated signaling pathwayGO:0192219.3ICAM1, HLA-DRB1, IL1B, IL6
33positive regulation of nitric oxide biosynthetic processGO:0454299.2SOD2, ICAM1, TNF, IL1B, IL6
34negative regulation of fat cell differentiationGO:0455999.2SOD2, TNF, IL6, TGFB1
35positive regulation of protein kinase B signaling cascadeGO:0518979.1TNF, IL6, TGFB1
36platelet degranulationGO:0025769.1TGFB1, ALB, SOD1
37positive regulation of protein phosphorylationGO:0019349.0TGFB1, IL1B, TNF
38platelet activationGO:0301689.0SOD1, IL6, ALB, TGFB1
39positive regulation of NF-kappaB transcription factor activityGO:0510928.8ICAM1, TNF, IL1B, IL6, TGFB1
40negative regulation of cell proliferationGO:0082858.6TGFB1, IL6, IL1B, IL8, TNF, SOD2
41positive regulation of transcription, DNA-dependentGO:0458938.6TGFB1, IL6, IL1B, IL10, TNF
42immune responseGO:0069558.5IL1B, IL8, CXCL2, IGHE, HLA-DRB1
43positive regulation of apoptotic processGO:0430658.3TGFB1, IL6, TNF, SOD1
44response to drugGO:0424938.2SOD2, SOD1, ICAM1, TNF, IL10, IL6
45inflammatory responseGO:0069547.5TGFB1, TNF, CD14, CXCL2, IL10, IL8

Molecular functions related to Extrinsic Allergic Alveolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1superoxide dismutase activityGO:0047849.9SOD1, SOD2
2cytokine activityGO:0051258.7IL6, IL1B, IL10, TNF

Products for genes affiliated with Extrinsic Allergic Alveolitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Extrinsic Allergic Alveolitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet