MCID: EXT034
MIFTS: 57

Extrinsic Allergic Alveolitis

Categories: Rare diseases, Respiratory diseases, Immune diseases

Aliases & Classifications for Extrinsic Allergic Alveolitis

MalaCards integrated aliases for Extrinsic Allergic Alveolitis:

Name: Extrinsic Allergic Alveolitis 12 36 14 69
Alveolitis, Extrinsic Allergic 72 49 41
Hypersensitivity Pneumonitis 12 49 59
Alveolitis 12 51 69
Extrinsic Allergic Pneumonia Hypersensitivity Pneumonitis 49
Allergic Interstitial Pneumonitis 49
Pneumonitis Hypersensitivity 51
Allergic Pneumonitis 49
Hp 49

Classifications:



External Ids:

Disease Ontology 12 DOID:841
ICD10 32 J67.9 J67 J67.8
ICD9CM 34 495 495.9
MeSH 41 D000542
NCIt 46 C34369
KEGG 36 H00346

Summaries for Extrinsic Allergic Alveolitis

PubMed Health : 59
About hypersensitivity pneumonitis: Hypersensitivity pneumonitis (noo-mo-NI-tis), or HP, is a disease in which the lungs become inflamed from breathing in foreign substances, such as molds, dusts, and chemicals. These substances also are known as antigens (AN-tih-jens).People are exposed to antigens at home, while at work, and in other settings. However, most people who breathe in these substances don't develop HP.

MalaCards based summary : Extrinsic Allergic Alveolitis, also known as alveolitis, extrinsic allergic, is related to farmer's lung and cork-handlers' disease, and has symptoms including hemoptysis An important gene associated with Extrinsic Allergic Alveolitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azathioprine and Pirfenidone have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

NIH Rare Diseases : 49 This condition doesn't have a summary yet. Please see our page(s) on Interstitial lung disease.

Wikipedia : 72 Hypersensitivity pneumonitis (HP; also called allergic alveolitis or extrinsic allergic alveolitis, EAA)... more...

Related Diseases for Extrinsic Allergic Alveolitis

Diseases related to Extrinsic Allergic Alveolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 321)
# Related Disease Score Top Affiliating Genes
1 farmer's lung 32.7 CD79A PI3
2 cork-handlers' disease 32.6 ALB CD79A
3 bagassosis 32.6 CXCL8 IL1B IL6
4 crohn's disease 31.7 IL10 IL1B IL6
5 bronchopneumonia 31.6 CD79A MPO PI3
6 mastitis 31.3 ALB CCL5 CXCL8 IL6
7 hemophagocytic lymphohistiocytosis 30.8 CCL2 CXCL8 IL10 IL2RA
8 allergic hypersensitivity disease 30.7 CCL5 FCER2 IL10
9 trypanosomiasis 30.7 ALB CCL2 CCL5 CXCL8 IL10 IL1B
10 malaria 30.3 ALB CCL2 CCL5 CXCL8 CXCR3 IL10
11 aspergillosis 30.3 CD79A IL10 SFTPD
12 pulmonary fibrosis 30.3 CCL2 IL1B SFTPD
13 celiac disease 1 30.2 ALB CD79A IL10
14 arthritis 29.8 CCL2 CXCL8 IL10 IL1B IL6
15 pulmonary fibrosis, idiopathic 28.9 CCL2 CCL5 CXCL8 CXCR3 IL1B SFTPD
16 interstitial lung disease 28.7 CCL2 CCL5 CXCL8 IL10 IL1B IL6
17 lung disease 28.5 CCL2 CCL5 CXCL8 IL10 IL1B MPO
18 pulmonary sarcoidosis 28.3 CCL2 CCL5 CXCR3 IL2RA SFTPD
19 pneumonia 27.9 CCL2 CCL5 CXCL8 IL10 IL1B IL6
20 asthma 27.4 CCL2 CCL5 CD79A CXCL8 FCER2 IL10
21 hantavirus pulmonary syndrome 12.0
22 house allergic alveolitis 11.9
23 pancreatitis, hereditary 11.7
24 bird fancier's lung 11.6
25 hermansky-pudlak syndrome 11.5
26 hepatopulmonary syndrome 11.5
27 pulmonary tuberculosis 11.3
28 hypersensitivity pneumonitis, familial 11.2
29 ventilation pneumonitis 11.2
30 malt worker's lung 11.2
31 mushroom workers' lung 11.2
32 sick building syndrome 11.2
33 ceroid lipofuscinosis, neuronal, 3 11.2
34 hermansky-pudlak syndrome 2 11.2
35 anhaptoglobinemia 11.1
36 plasmodium falciparum malaria 11.0
37 hermansky-pudlak syndrome 1 11.0
38 hermansky-pudlak syndrome 5 11.0
39 paroxysmal nocturnal hemoglobinuria 11.0
40 hellp syndrome 11.0
41 hemoglobinuria 11.0
42 gilbert syndrome 10.9
43 anemia, autoimmune hemolytic 10.9
44 hemochromatosis, type 1 10.9
45 anemia, nonspherocytic hemolytic, due to g6pd deficiency 10.9
46 alpha-thalassemia 10.9
47 congenital disorder of glycosylation, type in 10.9
48 hemolytic anemia 10.9
49 sleeping sickness 10.9
50 methemoglobinemia 10.9

Comorbidity relations with Extrinsic Allergic Alveolitis via Phenotypic Disease Network (PDN):


Heart Disease Postinflammatory Pulmonary Fibrosis

Graphical network of the top 20 diseases related to Extrinsic Allergic Alveolitis:



Diseases related to Extrinsic Allergic Alveolitis

Symptoms & Phenotypes for Extrinsic Allergic Alveolitis

UMLS symptoms related to Extrinsic Allergic Alveolitis:


hemoptysis

MGI Mouse Phenotypes related to Extrinsic Allergic Alveolitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 IL10 IL1B IL2RA IL6 MPO CCL5
2 homeostasis/metabolism MP:0005376 9.9 IL10 IL1B IL2RA ALB IL6 MPO
3 immune system MP:0005387 9.73 IL10 IL1B IL2RA IL6 CCL2 MPO
4 neoplasm MP:0002006 9.17 IL10 IL1B ALB IL6 CD79A SOD2

Drugs & Therapeutics for Extrinsic Allergic Alveolitis

PubMedHealth treatment related to Extrinsic Allergic Alveolitis: 59

The best way to treat hypersensitivity pneumonitis (HP) is to avoid the antigen that caused it. (An antigen is a substance that your body reacts against, such as molds, dusts, and chemicals.)In acute (short-term) HP, symptoms usually go away once you're no longer in contact with the antigen. In chronic (ongoing) HP, you may need medicines to relieve your symptoms.People who have chronic HP may develop pulmonary fibrosis. This is a condition in which tissue deep in your lungs becomes scarred over time. People who have this condition may need further treatment, such as oxygen therapy and pulmonary rehabilitation (rehab).

Drugs for Extrinsic Allergic Alveolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 2, Phase 3 446-86-6 2265
2
Pirfenidone Approved, Investigational Phase 2, Phase 3 53179-13-8 40632
3
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
4 Analgesics Phase 2, Phase 3
5 glucocorticoids Phase 2, Phase 3
6 Analgesics, Non-Narcotic Phase 2, Phase 3
7 Hormone Antagonists Phase 2, Phase 3
8 Hormones Phase 2, Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
10 Peripheral Nervous System Agents Phase 2, Phase 3
11 Immunosuppressive Agents Phase 2, Phase 3
12 Antimetabolites Phase 2, Phase 3
13 Anti-Inflammatory Agents Phase 2, Phase 3
14 Antimetabolites, Antineoplastic Phase 2, Phase 3
15 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
16 Antineoplastic Agents, Hormonal Phase 2, Phase 3
17 Antirheumatic Agents Phase 2, Phase 3
18
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
19
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
20 Autonomic Agents Phase 2
21 Prednisolone acetate Phase 2
22 Methylprednisolone acetate Phase 2
23 Methylprednisolone Hemisuccinate Phase 2
24 Gastrointestinal Agents Phase 2
25 Neuroprotective Agents Phase 2
26 Antiemetics Phase 2
27 Prednisolone hemisuccinate Phase 2
28 Prednisolone phosphate Phase 2
29 Protective Agents Phase 2
30
Heparin Approved, Investigational 9005-49-6 46507594 772
31 Pepsin A
32 Immunoglobulins
33 Antibodies
34 calcium heparin
35 Pharmaceutical Solutions
36 Respiratory System Agents
37 Adrenergic Agents
38 Adrenergic Agonists
39 Adrenergic beta-2 Receptor Agonists
40 Adrenergic beta-Agonists
41 Albuterol
42 Tocolytic Agents
43 Neurotransmitter Agents
44 Anti-Asthmatic Agents
45 Bronchodilator Agents

Interventional clinical trials:

(show all 17)

# Name Status NCT ID Phase Drugs
1 Pirfenidone in the Chronic Hypersensitivity Pneumonitis Treatment Unknown status NCT02496182 Phase 2, Phase 3 Placebo;Pirfenidone;Pirfenidone
2 Stop Exogenous Allergic Alveolitis (EAA) in Childhood Suspended NCT02631603 Phase 2 Placebo;Prednisolone
3 The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis Unknown status NCT01714934
4 Bronchoalveolar Immune Response Determination Completed NCT01237145
5 Wind Instruments' Fungal Contamination Completed NCT01487850
6 Work-related Respiratory Symptoms in Champagne Vineyard Workers Completed NCT02883920
7 Explorative Study on the Molecular Pathology of Lung Fibrosis by Combination of Clinical Assessment and System Biology Completed NCT01687946
8 Supplemental Oxygen in Pulmonary Fibrosis Completed NCT01961362
9 Study of Efficacy and Safety of Pirfenidone in Patients With Fibrotic Hypersensitivity Pneumonitis Recruiting NCT02958917 Pirfenidone
10 Research for Specific Proteins of Interest for the Serological Diagnosis of Bird Fancier's Lung Recruiting NCT03056404
11 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Recruiting NCT02596347
12 Toward Self-management in ILD Recruiting NCT03300583
13 Pulmonary Fibrosis Contact Registry Recruiting NCT01935726
14 Lung MRI in the Management of Idiopathic Pulmonary Fibrosis Recruiting NCT03078426
15 Clinical Course of Interstitial Lung Diseases: European IPF Registry and Biobank Recruiting NCT02951416
16 Small Airway Involvement in Patients With Chronic Hypersensitivity Pneumonitis Active, not recruiting NCT02523833 Salbutamol
17 Pulmonary Hypertension in Hypersensitivity Pneumonitis Enrolling by invitation NCT03030807

Search NIH Clinical Center for Extrinsic Allergic Alveolitis

Cochrane evidence based reviews: alveolitis, extrinsic allergic

Genetic Tests for Extrinsic Allergic Alveolitis

Anatomical Context for Extrinsic Allergic Alveolitis

MalaCards organs/tissues related to Extrinsic Allergic Alveolitis:

38
Lung, Testes, Monocytes, Neutrophil, T Cells, Myeloid, Skin

Publications for Extrinsic Allergic Alveolitis

Articles related to Extrinsic Allergic Alveolitis:

(show top 50) (show all 161)
# Title Authors Year
1
Spotlight on the diagnosis of extrinsic allergic alveolitis (hypersensitivity pneumonitis). ( 25914724 )
2015
2
Hypersensitivity pneumonitis (extrinsic allergic alveolitis): A Canadian historical perspective. ( 25299221 )
2014
3
Influence of age on manifestation, VC and TLCO values and bronchoalveolar lavage cell counts of sarcoidosis and extrinsic allergic alveolitis: Fibrotic response as a hallmark of aging? ( 24406019 )
2014
4
PAR-2, IL-4R, TGF-I^ and TNF-I+ in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis. ( 25009615 )
2014
5
Linear and nonlinear analysis of base lung sound in extrinsic allergic alveolitis patients in comparison to healthy subjects. ( 23591730 )
2013
6
Role of interleukin 4 and its receptor in clinical presentation of chronic extrinsic allergic alveolitis: a pilot study. ( 23721656 )
2013
7
Extrinsic allergic alveolitis as an uncommon diagnostic pitfall in lung cytology. ( 21656702 )
2012
8
New occupational and environmental causes of asthma and extrinsic allergic alveolitis. ( 23153603 )
2012
9
Surfactant protein A in chronic extrinsic allergic alveolitis. ( 22654012 )
2012
10
Acute life-threatening extrinsic allergic alveolitis in a paint controller. ( 21824996 )
2011
11
Mortality trends in asbestosis, extrinsic allergic alveolitis and sarcoidosis in England and Wales. ( 21704503 )
2011
12
Significance of specific IgG against sensitizing antigens in extrinsic allergic alveolitis: serological methods in EAA. ( 21924863 )
2011
13
Angiogenic activity of sera from extrinsic allergic alveolitis patients in relation to clinical, radiological, and functional pulmonary changes. ( 20607270 )
2010
14
Clinical features and prognosis in 21 patients with extrinsic allergic alveolitis. ( 20120765 )
2009
15
Extrinsic allergic alveolitis with an atypical immune expression. ( 19280076 )
2009
16
Extrinsic allergic alveolitis with eosinophil infiltration induced by 1,1,1,2-tetrafluoroethane (HFC-134a): a case report. ( 17827848 )
2007
17
Extrinsic allergic alveolitis: incidence and mortality in the general population. ( 17307752 )
2007
18
Extrinsic allergic alveolitis: comparative study of the bronchoalveolar lavage profiles and radiological presentation. ( 16954458 )
2006
19
Extrinsic allergic alveolitis. ( 16635083 )
2006
20
An unusual case of an acquired acral partial lipodystrophy (Barraquer-Simons syndrome) in a patient with extrinsic allergic alveolitis. ( 16716174 )
2006
21
Extrinsic allergic alveolitis (hypersensitivity pneumonitis) caused by Sphingobacterium spiritivorum from the water reservoir of a steam iron. ( 16145174 )
2005
22
Cockade-like structures in alveolar macrophages in extrinsic allergic alveolitis - another piece in the puzzle? ( 15753631 )
2005
23
Cockade-like structures in alveolar macrophages in extrinsic allergic alveolitis. ( 15753634 )
2005
24
Production of soluble tumor necrosis factor receptors and tumor necrosis factor-alpha by alveolar macrophages in sarcoidosis and extrinsic allergic alveolitis. ( 15653992 )
2005
25
Extrinsic allergic alveolitis caused by misting fountains. ( 15950134 )
2005
26
Involvement of eicosanoids and surfactant protein D in extrinsic allergic alveolitis. ( 16319337 )
2005
27
Extrinsic allergic alveolitis with IgA deficiency. ( 15689306 )
2004
28
Extrinsic allergic alveolitis in practice. ( 15114816 )
2004
29
Extrinsic allergic alveolitis: inhibitory effects of pentoxifylline on cytokine production by alveolar macrophages. ( 14989392 )
2004
30
[Preliminary study on effect of pentoxifylline in treatment of extrinsic allergic alveolitis]. ( 15061967 )
2004
31
Blood myeloid and lymphoid dendritic cells reflect Th1/Th2 balance in sarcoidosis and extrinsic allergic alveolitis. ( 15314973 )
2003
32
The HRCT features of extrinsic allergic alveolitis. ( 16088561 )
2003
33
[Biochemical characteristics of fluid and cells of bronchoalveolar washings in patients with extrinsic allergic alveolitis]. ( 12474462 )
2002
34
Extrinsic allergic alveolitis induced by the yeast Debaryomyces hansenii. ( 12449192 )
2002
35
IgG antibodies typical for extrinsic allergic alveolitis--an inter-laboratory quality assessment. ( 11726311 )
2001
36
Extrinsic allergic alveolitis from a proteolytic enzyme. ( 11345286 )
2001
37
Sulfasalazine-induced extrinsic allergic alveolitis in a patient with psoriatic arthritis. ( 11726310 )
2001
38
Respiratory syndrome very similar to extrinsic allergic alveolitis due to Penicillium verrucosum in workers in a cheese factory. ( 11307594 )
2001
39
Extrinsic allergic alveolitis caused by cabreuva wood dust. ( 11031353 )
2000
40
Histologically proven extrinsic allergic alveolitis with severe obstructive pulmonary emphysema ( 10756171 )
2000
41
Extrinsic allergic alveolitis in domestic environments (Domestic allergic alveolitis) caused by mouldy tapestry ( 10756168 )
2000
42
Pet-fish food lung- a new form of extrinsic allergic alveolitis. ( 10756166 )
2000
43
A family with extrinsic allergic alveolitis caused by wild city pigeons: A case report. ( 10799626 )
2000
44
BN 52021 decreases alveolar macrophage-mediated lung injury in experimental extrinsic allergic alveolitis. ( 10704058 )
1999
45
Effects of erythromycin on experimental extrinsic allergic alveolitis. ( 10051731 )
1999
46
Mucosal immunity in extrinsic allergic alveolitis: salivary immunoglobulins and antibody against inhaled avian antigens among pigeon breeders. ( 10383597 )
1999
47
Aerobiological analysis in a salami factory: a possible case of extrinsic allergic alveolitis by Penicillium camembertii. ( 10421864 )
1999
48
Elevated levels of soluble TNF receptors in bronchoalveolar lavage fluid in extrinsic allergic alveolitis. ( 10469029 )
1999
49
Clozapine-induced extrinsic allergic alveolitis. ( 9926066 )
1998
50
BN 52021 (a platelet activating factor-receptor antagonist) decreases alveolar macrophage-mediated lung injury in experimental extrinsic allergic alveolitis. ( 9705608 )
1998

Variations for Extrinsic Allergic Alveolitis

Expression for Extrinsic Allergic Alveolitis

Search GEO for disease gene expression data for Extrinsic Allergic Alveolitis.

Pathways for Extrinsic Allergic Alveolitis

Pathways related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 CCL2 CCL5 CD79A CXCL8 FCER2 IL10
2
Show member pathways
13.76 CCL2 CCL5 CXCL8 CXCR3 IL10 IL1B
3
Show member pathways
13.53 CCL2 CCL5 CXCL8 CXCR3 FCER2 IL10
4
Show member pathways
13.48 CCL2 CCL5 CXCL8 IL10 IL1B IL2RA
5
Show member pathways
13.35 CCL2 CCL5 CXCL8 CXCR3 IL10 IL1B
6
Show member pathways
13.28 CCL2 CCL5 CXCL8 FCER2 IL10 IL1B
7
Show member pathways
13.2 CCL2 CCL5 CXCL8 CXCR3 IL10 IL1B
8
Show member pathways
12.92 CCL2 CCL5 CXCL8 IL1B IL6
9
Show member pathways
12.82 CXCL8 IL10 IL1B IL2RA IL6
10
Show member pathways
12.73 CCL2 CCL5 CXCL8 IL1B IL2RA IL6
11
Show member pathways
12.59 CCL2 IL10 IL1B IL6 MPO
12
Show member pathways
12.54 IL10 IL1B IL2RA IL6
13
Show member pathways
12.44 CCL2 CCL5 CXCL8 IL10 IL1B IL6
14 12.43 CCL2 CCL5 CD79A IL10 IL1B IL2RA
15
Show member pathways
12.31 CCL2 CXCL8 IL1B IL6
16
Show member pathways
12.18 CXCL8 IL1B IL6 SFTPD
17 12.18 CXCL8 IL10 IL1B IL6
18
Show member pathways
12.14 CXCL8 IL10 IL1B IL6
19 12 CCL2 CXCL8 IL1B IL6
20
Show member pathways
11.98 CCL2 CCL5 CXCL8 CXCR3
21 11.93 CCL2 CCL5 IL1B IL6
22 11.92 CD79A IL10 IL2RA IL6 MPO
23 11.9 CXCL8 IL1B IL6
24
Show member pathways
11.89 IL10 IL1B IL6
25 11.89 CCL2 CXCL8 IL1B IL6
26 11.87 FCER2 IL1B IL2RA IL6
27 11.86 CXCL8 IL10 IL1B IL6
28
Show member pathways
11.83 ALB CCL2 CCL5 IL1B IL6 MPO
29 11.8 CXCL8 IL1B IL6
30 11.79 CCL2 CCL5 CXCL8 IL1B IL6
31 11.75 CXCR3 IL10 IL1B IL2RA
32 11.73 IL10 IL1B IL6
33 11.69 CXCL8 IL10 IL1B IL6
34 11.69 CCL2 CXCL8 FCER2 IL10 IL1B IL6
35 11.67 IL10 IL2RA IL6
36
Show member pathways
11.65 CXCL8 IL1B IL6
37 11.59 CXCL8 IL1B IL6
38 11.52 CCL2 CCL5 CXCL8 IL1B IL6
39 11.37 IL10 IL1B IL6
40 11.37 IL10 IL1B IL6
41 11.36 CCL5 IL1B IL6
42 11.35 CCL2 CXCL8 IL6
43 11.34 CCL2 CXCL8 IL10 IL1B IL6
44 11.28 IL10 IL1B IL6
45 11.11 CCL2 CCL5 CXCL8 IL10 IL1B IL6
46 10.99 CCL2 CCL5 CXCL8 IL10 IL1B IL6
47 10.9 CCL2 IL1B MPO
48 10.86 CCL2 CCL5 CXCL8 FCER2 IL10 IL1B
49 10.77 IL1B IL6

GO Terms for Extrinsic Allergic Alveolitis

Cellular components related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 ALB CCL2 CCL5 CXCL8 IL10 IL1B
2 external side of plasma membrane GO:0009897 9.46 CD79A CXCR3 FCER2 IL2RA
3 extracellular region GO:0005576 9.36 ALB CCL2 CCL5 CXCL8 FCER2 IL10

Biological processes related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.97 ALB IL10 IL6 MPO SOD2
2 negative regulation of cell proliferation GO:0008285 9.95 CXCL8 IL10 IL1B IL6 SOD2
3 MAPK cascade GO:0000165 9.9 CCL2 CCL5 IL1B IL2RA
4 cell surface receptor signaling pathway GO:0007166 9.89 CCL2 CD79A CXCR3 IL2RA
5 regulation of receptor activity GO:0010469 9.88 CCL2 CCL5 CXCL8 IL10 IL1B IL6
6 response to lipopolysaccharide GO:0032496 9.86 IL10 IL1B MPO SOD2
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.82 IL10 IL1B IL6
8 chemotaxis GO:0006935 9.81 CCL2 CCL5 CXCL8 CXCR3
9 cellular response to organic cyclic compound GO:0071407 9.76 CCL2 CCL5 IL1B
10 cellular response to interleukin-1 GO:0071347 9.75 CCL2 CCL5 CXCL8
11 cellular response to lipopolysaccharide GO:0071222 9.73 CCL2 CXCL8 IL10 IL6
12 protein kinase B signaling GO:0043491 9.71 CCL2 CCL5 IL1B
13 monocyte chemotaxis GO:0002548 9.7 CCL2 CCL5 IL6
14 negative regulation of T cell proliferation GO:0042130 9.67 IL10 IL2RA SFTPD
15 chemokine-mediated signaling pathway GO:0070098 9.67 CCL2 CCL5 CXCL8 CXCR3
16 cellular response to fibroblast growth factor stimulus GO:0044344 9.65 CCL2 CCL5 CXCL8
17 negative regulation of growth of symbiont in host GO:0044130 9.64 IL10 MPO
18 removal of superoxide radicals GO:0019430 9.64 MPO SOD2
19 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.63 CCL2 FCER2
20 response to molecule of bacterial origin GO:0002237 9.63 CXCL8 IL10
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.63 CCL2 CCL5 IL1B
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL10 IL1B
23 PERK-mediated unfolded protein response GO:0036499 9.62 CCL2 CXCL8
24 neutrophil chemotaxis GO:0030593 9.62 CCL2 CCL5 CXCL8 IL1B
25 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.61 CCL5 CXCL8
26 neutrophil activation GO:0042119 9.61 CCL5 CXCL8
27 immune response GO:0006955 9.5 CCL2 CCL5 CXCL8 IL10 IL1B IL2RA
28 positive regulation of T cell proliferation GO:0042102 9.46 CCL5 IL1B IL2RA IL6
29 macrophage chemotaxis GO:0048246 9.43 CCL2 CCL5 SFTPD
30 inflammatory response GO:0006954 9.23 CCL2 CCL5 CXCL8 CXCR3 IL10 IL1B

Molecular functions related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.13 CCL2 CCL5 CXCL8
2 cytokine activity GO:0005125 9.1 CCL2 CCL5 CXCL8 IL10 IL1B IL6

Sources for Extrinsic Allergic Alveolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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