MCID: EXD008
MIFTS: 60

Exudative Vitreoretinopathy 1 malady

Categories: Genetic diseases, Rare diseases, Eye diseases, Neuronal diseases, Cardiovascular diseases

Aliases & Classifications for Exudative Vitreoretinopathy 1

About this section
Sources:
11Disease Ontology, 13DISEASES, 23GeneReviews, 24GeneTests, 27GTR, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 37MedGen, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 52OMIM, 54Orphanet, 62SNOMED-CT, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet, 70UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Exudative Vitreoretinopathy 1:

Name: Exudative Vitreoretinopathy 1 52 68
Retinopathy of Prematurity 52 11 48 24 54 27 39 13 68
Retrolental Fibroplasia 11 48 54
Familial Exudative Vitreoretinopathy, Autosomal Dominant 23 24
Autosomal Dominant Familial Exudative Vitreoretinopathy 70 27
Vitreoretinopathy, Exudative 1 70 27
 
Adfevr 23 24
Rop 48 54
Criswick-Schepens Syndrome 70
Premature Retinopathy 11
Fevr 70
Evr1 70

Characteristics:

Orphanet epidemiological data:

54
retinopathy of prematurity:
Age of onset: Infancy,Neonatal; Age of death: normal life expectancy

HPO:

64
exudative vitreoretinopathy 1:
Inheritance: autosomal dominant inheritance
Onset and clinical course: infantile onset, slow progression

GeneReviews:

23
Penetrance: when using fluorescein angiography to determine clinical status, penetrance is reported to be 100% because all affected individuals have a sector of avascular peripheral retina [ober et al 1980]. ...


Classifications:

Orphanet: 54 
Rare eye diseases


External Ids:

OMIM52 133780
Disease Ontology11 DOID:13025
ICD9CM32 362.20, 362.21
MeSH39 D012178
NCIt45 C34982
Orphanet54 ORPHA90050
UMLS via Orphanet69 C0035344
MESH via Orphanet40 D012178
ICD10 via Orphanet31 H35.1

Summaries for Exudative Vitreoretinopathy 1

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OMIM:52 Familial exudative vitreoretinopathy (FEVR) is an inherited disorder characterized by the incomplete development of the... (133780) more...

MalaCards based summary: Exudative Vitreoretinopathy 1, also known as retinopathy of prematurity, is related to fzd4-related familial exudative vitreoretinopathy, autosomal dominant and lrp5-related familial exudative vitreoretinopathy, autosomal dominant, and has symptoms including subcapsular cataract, retinal detachment and blindness. An important gene associated with Exudative Vitreoretinopathy 1 is FZD4 (Frizzled Class Receptor 4), and among its related pathways are VEGF binds to VEGFR leading to receptor dimerization and Vemurafenib Pathway, Pharmacodynamics. Affiliated tissues include eye, retina and lung, and related mouse phenotypes are integument and respiratory system.

UniProtKB/Swiss-Prot:70 Vitreoretinopathy, exudative 1: A disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. Clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease related abnormality is an arc of avascular retina in the extreme temporal periphery. In many ways the disease resembles retinopathy of prematurity but there is no evidence of prematurity or small birth weight in the patient history.

GeneReviews for NBK1147

Related Diseases for Exudative Vitreoretinopathy 1

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Diseases in the Exudative Vitreoretinopathy family:

Exudative Vitreoretinopathy 5 Exudative Vitreoretinopathy 3
Exudative Vitreoretinopathy 6 Exudative Vitreoretinopathy 4
exudative vitreoretinopathy 1 Lrp5-Related Familial Exudative Vitreoretinopathy, Autosomal Recessive
Fzd4-Related Familial Exudative Vitreoretinopathy, Autosomal Dominant Lrp5-Related Familial Exudative Vitreoretinopathy, Autosomal Dominant
Tspan12-Related Familial Exudative Vitreoretinopathy, Autosomal Dominant

Diseases related to Exudative Vitreoretinopathy 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1fzd4-related familial exudative vitreoretinopathy, autosomal dominant12.2
2lrp5-related familial exudative vitreoretinopathy, autosomal dominant12.2
3tspan12-related familial exudative vitreoretinopathy, autosomal dominant12.2
4ndp-related retinopathy of prematurity12.0
5exudative vitreoretinopathy11.1
6exudative vitreoretinopathy 510.8
7microcephaly with or without chorioretinopathy, lymphedema, or mental retardation10.8
8exudative vitreoretinopathy 310.8
9exudative vitreoretinopathy 410.8
10exudative vitreoretinopathy 2, x-linked10.8
11microcephaly and chorioretinopathy, autosomal recessive, 110.8
12pediatric extraocular retinoblastoma10.6FZD4, NDP, TSPAN12
13hyperostosis, endosteal10.6FZD4, LRP5, NDP
14regular astigmatism10.6FZD4, LRP5, NDP
15bladder urachal carcinoma10.5FLT1, KDR, VEGFA
16nystagmus 5, congenital, x-linked10.5FZD4, LRP5, NDP, TSPAN12
17perivascular epithelioid cell tumor10.5IGF1, KDR, VEGFA
18silicosiderosis10.5KDR, VEGFA
19epidermolysis bullosa10.5KDR, TEK, VEGFA
20lens disease10.4FLT1, KDR, VEGFA
21arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay10.4FZD4, KDR, NDP, VEGFA
22iridogoniodysgenesis and skeletal anomalies10.4HIF1A, VEGFA
23acute lymphoblastic leukemia congenital sporadic aniridia10.4ANGPT2, FLT1, VEGFA
24tuberculous peritonitis10.4FZD4, NDP
25retinitis10.4
26diabetes mellitus, insulin-dependent, 310.4ANGPT2, KDR, VEGFA
27lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy10.4FLT1, KDR, VEGFA
28chikungunya10.4FLT1, KDR, VEGFA
29colorectal adenoma10.4TEK, VEGFA
30acute myeloblastic leukemia without maturation10.4FLT1, HIF1A, VEGFA
31striatonigral degeneration10.4ANGPT2, FLT1, TEK
32spinal cord astrocytoma10.4FLT1, VEGFA
33endotheliitis10.4
34dental pulp disease10.4FZD4, LRP5, NDP, TSPAN12, VEGFA
35verloove vanhorick brubakk syndrome10.3HIF1A, KDR, VEGFA
36vertebral artery occlusion10.3ANGPT2, TEK, VEGFA
37neuropathy, hereditary sensory and autonomic, type vi10.3ANGPT2, FLT1, IGF1, VEGFA
38epidural abscess10.3FLT1, KDR, TEK, VEGFA
39third cranial nerve disease10.3FLT1, IGF1, KDR, VEGFA
40renal tubular transport disease10.2HIF1A, TEK, VEGFA
41renal fibrosis10.2HIF1A, KDR, TEK, VEGFA
42dic in newborn10.2EPO, SERPINH1
43hemangioma10.2
44skin hemangioma10.2
45hole retinal cyst10.1ANGPT2, VEGFA
46apocrine adenoma10.1ANGPT2, FLT1, KDR, TEK, VEGFA
47norrie disease10.1
48retinal detachment10.1
49refractive error10.1
50hematopoietic stem cell transplantation10.0FLT1, HIF1A, KDR, TEK, VEGFA

Graphical network of the top 20 diseases related to Exudative Vitreoretinopathy 1:



Diseases related to exudative vitreoretinopathy 1

Symptoms & Phenotypes for Exudative Vitreoretinopathy 1

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Symptoms by clinical synopsis from OMIM:

133780

Clinical features from OMIM:

133780

Human phenotypes related to Exudative Vitreoretinopathy 1:

 64 (show all 12)
id Description HPO Frequency HPO Source Accession
1 subcapsular cataract64 HP:0000523
2 retinal detachment64 HP:0000541
3 blindness64 HP:0000618
4 pigmentary retinal degeneration64 HP:0001146
5 retinal exudate64 HP:0001147
6 posterior vitreous detachment64 HP:0001489
7 falciform retinal fold64 HP:0001493
8 recurrent fractures64 HP:0002757
9 reduced visual acuity64 HP:0007663
10 peripheral retinal avascularization64 HP:0007685
11 vitreous hemorrhage64 HP:0007902
12 exudative vitreoretinopathy64 HP:0030490

UMLS symptoms related to Exudative Vitreoretinopathy 1:


hyperoxia, vitreous fibrin, disturbance of thermoregulation of newborn, eyelash injury

MGI Mouse Phenotypes related to Exudative Vitreoretinopathy 1 according to GeneCards Suite gene sharing:

41 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.7ANGPT2, ATP7B, EPO, FZD4, HIF1A, IGF1
2MP:00053889.6ANGPT2, EPO, HIF1A, IGF1, KDR, SERPINH1
3MP:00053809.4EPO, FLT1, FZD4, HIF1A, KDR, LRP5
4MP:00053699.4ATP7B, EPO, FLT1, FZD4, HIF1A, IGF1
5MP:00028739.4EPO, FLT1, FZD4, HIF1A, IGF1, KDR
6MP:00036319.0ATP7B, FLT1, FZD4, HIF1A, IGF1, KDR
7MP:00053878.9ANGPT2, ATP7B, CD38, EPO, FLT1, HIF1A
8MP:00053978.7ATP7B, CD38, EPO, FLT1, FZD4, HIF1A
9MP:00053858.7ANGPT2, EPO, FLT1, FZD4, HIF1A, IGF1
10MP:00053768.5ANGPT2, ATP7B, CD38, EPO, FLT1, FZD4
11MP:00053918.4ANGPT2, FLT1, FZD4, HIF1A, KDR, LRP5
12MP:00107688.4ANGPT2, ATP7B, CPVL, EPO, FLT1, FZD4

Drugs & Therapeutics for Exudative Vitreoretinopathy 1

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Drugs for Exudative Vitreoretinopathy 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 218)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IbuprofenapprovedPhase 4, Phase 3, Phase 250115687-27-13672
Synonyms:
(+-)-2-(P-Isobutylphenyl)propionic acid
(+-)-Ibuprofen
(+-)-P-Isobutylhydratropic acid
(+-)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid
(4-Isobutylphenyl)-alpha-methylacetic acid
(RS)-ibuprofen
139466-08-3
15687-27-1
2-(4-Isobutylphenyl)propanoic acid
4-Isobutylhydratropic acid
58560-75-1
AC-11312
AC1L1GGE
AC1Q1P84
AC1Q1P85
ACHES-N-PAIN
ARONIS23835
Act-3
Actiprofen
Adex 200
Adran
Advil
Advil (TN)
Advil Liqui-Gels
Ak+C2278tren
Alaxan
Algofen
Am-Fam 400
Amelior
Amersol
Amibufen
Anafen
Anco
Andran
Anflagen
Antagil
Antalfene
Antarene
Antiflam
Apo-Ibuprofen
Apsifen
Apsifen-F
Artofen
Artril
Artril 300
BB_SC-1358
BIDD:GT0050
BRN 2049713
Balkaprofen
Betaprofen
Bloom
Bluton
Brofen
Brufanic
Brufen
Brufen 400
Bruflam
Brufort
Buburone
Bufeno
Bufigen
Bukrefen
Bupron
Buracaps
Burana
Butylenin
C01588
C13H18O2
CCRIS 3223
CHEBI:5855
CHEMBL521
CID3672
CPD000058184
Cap-Profen
Carol
Cesra
Children's Advil
Children's Elixsure
Children's Ibuprofen
Children's Motrin
Citalgan
Cobo
Codral
Combiflam
Cunil
D00126
D007052
DB01050
DOLO PUREN
Daiprophen
Dalsy
Dansida
Deep Relief
Dentigoa
Dibufen
Dignoflex
Dolgin
Dolgirid
Dolgit
Dolibu
Dolmaral
Dolo-Dolgit
Dolo-dolgit
Dolocyl
Dolofen
Dolofen-F
Dolofin
Dolofort
Dologel
Dolomax
Doloren
Dolormin
Doltibil
Dolven
Donjust B
Dorival
Drin
Duafen
Duobrus
Dura-Ibu
Duralbuprofen
Dysdolen
EU-0100691
Easifon
Ebufac
Emflam
Emflam-200
Emodin
Epobron
Eputex
Ergix
Esprenit
Exneural
Faspic
Femadon
Femafen
Femapirin
Femidol
Fenbid
Fenbid Spansule
Fendol
Fenspan
Fibraflex
Gelufene
Gofen
Grefen
Gynofug
HMS1920F15
HMS2089P05
HMS2091N03
HMS502M09
HSDB 3099
Haltran
I 4883
I01-7039
I0415
I4883_SIGMA
I7905_SIAL
IB-100
IDI1_000887
IP 82
IP-82
IP82
Ibol
Ibren
Ibu
Ibu-Attritin
Ibu-Slo
Ibu-Tab
Ibu-Tab 200
Ibu-attritin
Ibu-slo
Ibu-slow
Ibubest
Ibubeta
Ibucasen
Ibudol
 
Ibudolor
Ibufen
Ibuflamar
Ibufug
Ibugel
Ibugen
Ibugesic
Ibuhexal
Ibulagic
Ibular
Ibulav
Ibuleve
Ibulgan
Ibumed
Ibumerck
Ibumetin
Ibupirac
Ibuprin
Ibuprocin
Ibuprofen
Ibuprofene
Ibuprofeno
Ibuprofenum
Ibuprohm
Ibuprophen
Ibusal
Ibutid
Ifen
Inabrin
Inflam
Inoven
Ipren
Irfen
Isodol
Jenaprofen
Junifen
Junior Strength Advil
Junior Strength Ibuprofen
Junior Strength Motrin
KBio1_000887
KBio2_001329
KBio2_003897
KBio2_006465
KBio3_001390
Kesan
Kratalgin
LS-7454
Lamidon
Lebrufen
Librofem
Lidifen
Liptan
Lopane
MLS000069733
MLS001146965
Malafene
Manypren
Medipren
Melfen
Mensoton
Midol
Midol 200
Moment
Motrin
Motrin (TN)
Motrin IB
Mynosedin
NCI60_002065
NINDS_000887
NSC 256857
NSC256857
Nagifen-D
Napacetin
Narfen
Neo-Helvagit
Neo-Mindol
NeoProfen
Neobrufen
Nerofen
Noalgil
Nobafon
Nobfelon
Nobfen
Nobgen
Noritis
Norton
Novadol
Novo-Profen
Novogent
Novogent N
Novoprofen
Nuprilan
Nuprin
Nurofen
Optifen
Opturem
Oralfene
Ostarin
Ostofen
Ozonol
P-Isobutylhydratropic Acid
Paduden
Panafen
Pantrop
Para-Isobutylhydratropic Acid
Paxofen
Pedia-Profen
PediaProfen
Pediaprofen
Pediatric Advil
Perofen
Proartinal
Profen
Proflex
Provon
Quadrax
R.D. 13621
RD 13621
Rafen
Ranofen
Rebugen
Relcofen
Rhinadvil
Rofen
Roidenin
Rufen
Rufin
Rupan
SAM002264619
SMR000058184
SPBio_000178
STK177358
Sadefen
Salivia
Salprofen
Seclodin
Sednafen
Seklodin
Seskafen
Siyafen
Solpaflex
Solufen
Stelar
Sugafen
Suprafen
Suspren
Syntofene
TL8001184
Tab-Profen
Tabalon
Tabalon 400
Tatanal
Tempil
Tofen
Togal N
Tonal
Trendar
U 18573
U-18,573
U-18573
UCB 79171
Unipron
Upfen
Uprofen
Urem
VUFB 9649
Zafen
Zofen
alpha-(4-Isobutylphenyl)propionate
alpha-(4-Isobutylphenyl)propionic acid
alpha-(P-Isobutylphenyl)propionic acid
alpha-p-Isobutylphenylpropionate
alpha-p-Isobutylphenylpropionic acid
ibuprofen
p-Isobutyl-2-phenylpropionate
p-Isobutyl-2-phenylpropionic acid
p-Isobutylhydratropate
p-Isobutylhydratropic acid
2
KetorolacapprovedPhase 4, Phase 230474103-06-3, 66635-83-43826
Synonyms:
(+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
(+-)-Ketorolac
(+-)-isomer
(.+/-.)-2,3-Dihydro-5-benzoyl-1H-pyrrolizine-1-carboxylic acid
1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro
5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
5-Benzoyl-1,2-dihydro-3H-pyrrolo(1,2a)pyrrole-1-carboxylic acid
5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
66635-83-4
74103-06-3
AB00053682
AC-545
AC1L1GSW
BRD-A40639672-234-05-7
C07062
CHEBI:105080
CHEMBL469
CID3826
D020910
D08104
DB00465
 
I14-2832
Ketoralac
Ketorolac
Ketorolac (INN)
Ketorolac Tromethamine
Ketorolac [INN:BAN]
Ketorolaco
Ketorolaco [Spanish]
Ketorolacum
Ketorolacum [Latin]
Kétorolac
LS-139094
Macril
MolPort-005-933-093
NCGC00185990-01
RS 37619
RS-37619
SBB067312
STL018674
Toradol (TN)
UNII-YZI5105V0L
ketorolac
rac-Ketorolac
3Poractant alfaapprovedPhase 425129069-19-8
4
Propofolapproved, investigational, vet_approvedPhase 410282078-54-84943
Synonyms:
2, 6-Diisopropylphenol
2,6 Diisopropylphenol
2,6-Bis(1-methylethyl)phenol
2,6-Bis(Isopropyl)-phenol
2,6-DIISOPROPYLPHENOL
2,6-Diisopropyl phenol
2,6-Diisopropylphenol
2,6-bis(1-methylethyl)-phenol
2,6-di(propan-2-yl)phenol
2078-54-8
28449-97-0
4-06-00-03435 (Beilstein Handbook Reference)
50356-15-5
AB00513968
AC-2038
AC1L1J9Y
AC1Q1OUI
AI3-26295
AM-149
Abbott Brand of Propofol
Alpha Brand of Propofol
Ampofol
Aquafol
Astra Brand of Propofol
AstraZeneca Brand of Propofol
BIDD:GT0436
BPBio1_000950
BPBio1_000969
BRD-K82255054-001-03-5
BRN 1866484
BSPBio_000862
Biomol-NT_000248
Braun Brand of Propofol
C07523
C12H18O
CAS-2078-54-8
CCRIS 9000
CHEBI:44915
CHEMBL526
CID4943
CPD-11437
CPD000059151
Curamed Brand of Propofol
D00549
D015742
D0617
D126608
D126608_ALDRICH
DB00818
DDS-04F
Diisopropylphenol
Dipravan
Diprivan
Diprivan (TN)
Diprivan Injectable emulsion
Disoprivan
Disoprofol
EINECS 218-206-6
EU-0100437
Fresenius Brand of Propofol
Fresenius Kabi Brand of Propofol
Fresofol
HMS1570L04
HMS2089O21
HMS2094E17
 
HSDB 7123
ICI 35,868
ICI 35868
ICI-35,868
ICI-35868
ICI35,868
ICI35868
InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H
Ivofol
Jsp004266
Juste Brand of Propofol
LS-996
Lopac-D126608
Lopac0_000437
MLS001066348
MLS001335999
MLS002454360
MolPort-001-794-517
NCGC00015389-01
NCGC00015389-02
NCGC00015389-04
NCGC00015389-09
NCGC00091538-01
NCGC00091538-02
NCGC00091538-03
NCGC00091538-04
NCGC00091538-05
NCGC00091538-06
NSC 5105
NSC5105
PFL
Parnell Brand of Propofol
Pisa Brand of Propofol
Prestwick0_000931
Prestwick1_000931
Prestwick2_000931
Prestwick3_000931
Propofol
Propofol (JAN/USAN/INN)
Propofol Abbott
Propofol Fresenius
Propofol IDD-D
Propofol MCT
Propofol Rovi
Propofol [USAN:INN:BAN]
Propofol(2,6-Diisopropylphenol)
Propofol-Lipuro
Propofolum
Propofolum [Latin]
Rapinovet
Recofol
Rovi Brand of Propofol
S01-0189
SAM002264610
SMR000059151
SPBio_003031
SPECTRUM1505022
ST50405911
Schering Brand of Propofol
UNII-YI7VU623SF
W505102_ALDRICH
ZD-0859
ZINC00968303
Zeneca Brand of Propofol
ghl.PD_Mitscher_leg0.558
nchembio.552-comp7
propofol
5
Nitrous oxideapproved, vet_approvedPhase 4, Phase 317010024-97-2948
Synonyms:
00583_FLUKA
10024-97-2
126386-65-0
129451-49-6
130835-71-1
147527-07-9
175876-44-5
295590_ALDRICH
794457-85-5
847968-13-2
850203-00-8
AC1L1ADZ
C00887
CCRIS 1225
CHEBI:17045
CHEMBL1234579
CID948
D00102
D009609
Diazyne 1-oxide
Dinitrogen monoxide
Dinitrogen oxide
Distickstoffmonoxid
E942
EINECS 233-032-0
FEMA 2779
FEMA No. 2779
Factitious air
Gas, Laughing
Gas, laughing
Gaz hilarant
HSDB 504
Hyponitrous acid anhydride
LS-7622
Lachgas
Laughing gas
N2O
NITROUS-OXIDE
NNO
 
Nitral
Nitrious oxide
Nitrogen hypoxide
Nitrogen monoxide
Nitrogen oxide (N2O)
Nitrogen protoxide
Nitrogenium oxydulatum
Nitrous oxide
Nitrous oxide (JP15/USP)
Nitrous oxide (TN)
Nitrous oxide [Anaesthetics, volatile]
Nitrous oxide [JAN]
Nitrous oxide [UN1070] [Nonflammable gas]
Nitrous oxide [UN1070] [Nonflammable gas]
Nitrous oxide [anaesthetics, volatile]
Nitrous oxide [jan]
Nitrous oxide, JAN, USAN
Nitrous oxide, compressed
Nitrous oxide, refrigerated liquid
Nitrous oxide, refrigerated liquid [UN2201] [Nonflammable gas]
Nitrous oxide, refrigerated liquid [UN2201] [Nonflammable gas]
Nitrous-oxide
Oxide, Nitrous
Oxide, nitrous
Oxido nitroso
Oxido nitroso [Spanish]
Oxidodinitrogen(N--N)
Oxyde nitreux
Protoxyde d'azote [French]
Stickdioxyd
Stickdioxyd [German]
Stickstoff(I)-oxid
UN1070
UN2201
gaz hilarant
nitrogenium oxydulatum
nitrous oxide
oxidodinitrogen(N--N)
oxyde nitreux
protoxyde d'azote
6
Ketamineapproved, vet_approvedPhase 45286740-88-13821
Synonyms:
(+-)-Ketamine
(+/-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
(+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
(+/-)-Ketamine
(-)-Ketamine
(S)-(-)-Ketamine
(S)-Ketamine
(±)-ketamine
100477-72-3
2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone
2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
2-(Methylamino)-2-(2-chlorophenyl)cyclohexanone
2-(methylamino)-2-(2-chlorophenyl)cyclohexanone
2-(o-Chlorophenyl)-2-(methylamino)-cyclohexanone
2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(o-chlorophenyl)-2-(methylamino)-cyclohexanone
33643-45-7
6740-88-1
79499-51-7
AC1L1GSH
AC1Q40UR
AKOS001053247
BRN 2216965
C07525
C13H16ClNO
CHEBI:138833
CHEBI:6121
CHEMBL742
CI 581 base
CI-581
CID3821
CLSTA 20
Calypsol
Cetamina
Cetamina [INN-Spanish]
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)- (9CI)
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)- (9CI)
Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+/-)- (8CI)
D08098
DB01221
DEA No. 7285
 
DL-ketamine
DivK1c_000217
EINECS 229-804-1
Esketamine
Green
IDI1_000217
KBio1_000217
KETAMINE
KETAMINE HCL
Ketaject
Ketalar
Ketalar base
Ketamina
Ketamine (INN)
Ketamine Base
Ketamine HCL
Ketamine [INN:BAN]
Ketaminum
Ketaminum [INN-Latin]
Ketanest
Ketoject
Ketolar
L-Ketamine
LS-57301
MLS001331674
MolPort-001-838-070
NCGC00159480-02
NCGC00159480-03
NINDS_000217
NMDA
NSC 70151
NSC70151
SMR000238141
Special K
Special K [street name]
Special k
T385
Tekam
Tekam (TN)
UNII-690G0D6V8H
dl-Ketamine
ketamine
l-Ketamine
7
RanibizumabapprovedPhase 4, Phase 3, Phase 2474347396-82-1459903
Synonyms:
347396-82-1
D05697
Lucentis
Lucentis (TN)
 
Ranibizumab
Ranibizumab (USAN/INN)
Ranibizumab (genetical recombination)
Ranibizumab (genetical recombination) (JAN)
ranibizumab
rhuFab V2
8
Indomethacinapproved, investigationalPhase 4, Phase 311453-86-13715
Synonyms:
1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
1z9h
37242-43-6
503560-73-4
53-86-1
74252-25-8 (hydrochloride salt, tri-hydrate)
7681-54-1 (hydrochloride salt)
91853-74-6
AB00052022
AC-532
AC1L1GJQ
AKOS000592893
Aconip
Aconip (TN)
Amuno
Apo-Indomethacin
Arthrexin
Artracin
Artrinovo
Artrivia
BIDD:GT0132
BIM-0050670.0001
BPBio1_000160
BRD-K57222227-001-06-1
BRN 0497341
BSPBio_000144
BSPBio_001149
BSPBio_002176
Bio-0704
Bio2_000405
Bio2_000885
Bonidin
Bonidon
Bonidon Gel
C01926
CAS-53-86-1
CCRIS 3502
CHEBI:49662
CHEMBL6
CID3715
CPD-10545
Catlep
Chibro-amuno
Chrono-indicid
Chrono-indocid
Confortid
D00141
DB00328
DESMETHYL INDOMETHACIN
DivK1c_000271
Dolcidium
Dolcidium PL
Dolovin
Durametacin
EINECS 200-186-5
EU-0100692
Elmetacin
Flexin continus
HMS1362I11
HMS1568H06
HMS1792I11
HMS1920F21
HMS1990I11
HMS2089N19
HMS2091N09
HMS500N13
HSDB 3101
Hicin
I 7378
I0655
I7378_SIGMA
I8280_SIGMA
IDI1_000271
IDI1_002160
IMN
IN1454
Idomethine
Imbrilon
Inacid
Indacin
Indameth
Indmethacine
Indo-Lemmon
Indo-Spray
Indo-phlogont
Indo-rectolmin
Indo-tablinen
Indocid
Indocid (pharmaceutical)
Indocid Pda
Indocid Sr
Indocin
Indocin (TN)
Indocin I.V
Indocin I.V.
Indocin Sr
Indolar SR
Indomecol
Indomed
Indomee
Indomet 140
Indometacin
Indometacin (JP15/INN)
Indometacina
Indometacina [INN-Spanish]
Indometacine
Indometacine [INN-French]
Indometacinum
 
Indometacinum [INN-Latin]
Indometacyna
Indometacyna [Polish]
Indomethacin
Indomethacin & MAP-30
Indomethacin (USP)
Indomethacin [USAN:BAN]
Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin
Indomethacine
Indomethacinum
Indomethancin
Indomethazine
Indomethegan
Indomethine
Indometicina
Indometicina [Spanish]
Indomo
Indomod
Indoptic
Indoptol
Indorektal
Indoxen
Inflazon
Infrocin
Inteban sp
KBio1_000271
KBio2_000489
KBio2_001399
KBio2_003057
KBio2_003967
KBio2_005625
KBio2_006535
KBio3_000897
KBio3_000898
KBio3_001396
KBioGR_000395
KBioGR_000489
KBioSS_000489
KBioSS_001399
L000959
LS-187
LS-82147
Lausit
Liometacen
Lopac-I-7378
Lopac0_000692
MLS000069402
MLS000758212
MLS001074194
Metacen
Metartril
Methazine
Metindol
Mezolin
Miametan
Mikametan
Mobilan
MolMap_000032
MolPort-000-917-894
NCGC00015562-01
NCGC00015562-02
NCGC00015562-03
NCGC00015562-08
NCGC00015562-19
NCGC00024135-02
NCGC00024135-04
NCGC00024135-05
NCGC00024135-06
NCGC00024135-07
NCGC00024135-08
NCGC00024135-09
NCGC00024135-11
NCI-C56144
NCI60_041708
NINDS_000271
Novo-Methacin
Novomethacin
Oprea1_686105
Prestwick0_000272
Prestwick1_000272
Prestwick2_000272
Prestwick3_000272
Prestwick_597
Reumacide
Rhemacin LA
Rheumacin LA
S00108
S1723_Selleck
SMR000058195
SMR000449290
SPBio_000979
SPBio_002363
SPECTRUM1500350
Sadoreum
Spectrum2_000970
Spectrum3_000468
Spectrum4_000018
Spectrum5_000868
Spectrum_000919
Tannex
Tocris-1708
UNII-XXE1CET956
UPCMLD-DP023
UPCMLD-DP023:001
USAN
Vonum
indometacin
indomethacin
nchembio.147-comp11
{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid
9
Sevofluraneapproved, vet_approvedPhase 447928523-86-65206
Synonyms:
1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
28523-86-6
AC-15484
AC1L1JU0
BRN 2041023
Bax 3084
C009250
C07520
C4H3F7O
CHEBI:9130
CHEMBL1200694
CID5206
D00547
DB01236
F0691
Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether
Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
I14-13357
LS-67851
MR6S4
 
MR_6S4
MolPort-001-775-746
NCGC00167421-01
PC4681
Sevofluran
Sevoflurane
Sevoflurane (JAN/USAN/INN)
Sevoflurane [USAN:INN:BAN:JAN]
Sevoflurano
Sevoflurano [INN-Spanish]
Sevofluranum
Sevofluranum [INN-Latin]
Sevofrane
Sevorane
Sojourn
UNII-38LVP0K73A
Ultane
Ultane (TN)
ZINC01530810
fluoromethyl hexafluoroisopropyl ether
fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
sevoflurane
10
Caffeineapproved, NutraceuticalPhase 4, Phase 3, Phase 238058-08-22519
Synonyms:
07E4FB58-FD79-4175-8E3D-05BF96954522
1,3,7-Trimethyl-2,6-dioxopurine
1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione
1,3,7-Trimethylpurine-2,6-dione
1,3,7-Trimethylxanthine
1,3,7-trimethyl-2,6-dioxopurine
1,3,7-trimethylpurine-2,6-dione
1,3,7-trimethylxanthine
1-3-7-TRIMETHYLXANTHINE
1-Methyl-Theobromine
1-methyltheobromine
137X
1gfz
1l5q
1l7x
27602_FLUKA
2a3b
3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
3,7-dihydro-1,3,7-trimethyl-1H-purine
5-26-13-00558 (Beilstein)
58-08-2
7-Methyl Theophylline
7-Methyltheophylline
7-methyltheophylline
71701-02-5
75035_FLUKA
95789-13-2
A.S.A. and Codeine Compound
AC-12774
AC1L1DV2
AC1Q3Z23
ACon1_000085
AI3-20154
AKOS000121334
Alert-Pep
Alert-pep
Anacin Maximum Strength
Anhydrous caffeine
Anhydrous caffeine (JP15)
Anhydrous caffeine (TN)
Anoquan
BIDD:ER0554
BIDD:GT0632
BIDD:PXR0172
BIM-0050216.0001
BRD-K02404261-001-02-7
BRD-K02404261-001-03-5
BRN 0017705
BSPBio_001921
Berlin-Chemie Brand of Caffeine
Bio-0579
Bio1_000473
Bio1_000962
Bio1_001451
Bristol-Myers Squibb Brand of Caffeine
C 0750
C07481
C0750_SIAL
C1778_SIAL
C2042
C6035_FLUKA
C6035_SIGMA
C7731_SIAL
C8960_SIAL
CCRIS 1314
CFF
CHEBI:27732
CHEMBL113
CID2519
CU-01000012617-3
Cafamil
Cafcit
Cafecon
Cafeina
Cafergot
Cafeína
Caffedrine
Caffedrine Caplets
Caffein
Caffeina
Caffeina [Italian]
Caffeine (USP)
Caffeine (natural)
Caffeine Pure
Caffeine [BAN:JAN]
Caffeine solution
Caffeine, Anhydrous
Caffeine, Monohydrate
Caffeine, Synthetic
Caffeine, anhydrous
Caffeine, synthetic
Caffeinum
Caffine
Cafipel
Caféine
Coffein
Coffein [German]
Coffeine
Coffeinum
Coffeinum N
Coffeinum Purrum
Compound 65
D002110
D00528
DB00201
DHC Plus
DHCplus
Darvon Compound
Darvon Compound-65
Dasin
Dexitac
Dexitac Stay Alert Stimulant
Dhc Plus
Diurex
DivK1c_000730
Durvitan
EINECS 200-362-1
EU-0100228
Eldiatric C
Enerjets
Ercatab
Esgic
Esgic-Plus
FEMA No. 2224
Femcet
Fioricet
Fiorinal
GlaxoSmithKline Brand of Caffeine
Guaranine
HMS1920I09
HMS2091O11
HMS502E12
HSDB 36
Hycomine
Hycomine Compound
I14-4386
 
IDI1_000730
Invagesic
Invagesic Forte
KBio1_000730
KBio2_001781
KBio2_004349
KBio2_006917
KBio3_001141
KBioGR_002325
KBioSS_001781
Keep Alert
Kofein
Kofein [Czech]
Koffein
Koffein [German]
L000155
LS-237
Lanorinal
Lopac-C-0750
Lopac0_000228
MEGxp0_001350
MLS001055341
MLS001056714
MLS001066409
Mateina
Mateína
Maximum Strength Snapback Stimulant Powders
Medigesic Plus
Merck dura Brand of Caffeine
Methyltheobromide
Methyltheobromine
Methylxanthine theophylline
Midol Maximum Strength
Migergot
Miudol
MolMap_000054
MolPort-000-730-850
Monohydrate Caffeine
Monomethyl Derivative of Theophylline
Monomethyl derivative of Theophylline
NCGC00015208-01
NCGC00015208-02
NCGC00015208-04
NCGC00015208-14
NCGC00090699-01
NCGC00090699-02
NCGC00090699-03
NCGC00090699-04
NCGC00090699-05
NCGC00090699-06
NCGC00090699-07
NCGC00090699-08
NCGC00090699-09
NCGC00168808-01
NCGC00168808-02
NCI-C02733
NCIOpen2_008255
NINDS_000730
NSC 5036
NSC5036
Natural Caffeinum
Nix Nap
No Doz
No-Doz
Nodaca
Nodoz Maximum Strength Caplets
Norgesic
Norgesic Forte
Organex
Orphengesic
Orphengesic Forte
P-A-C Analgesic Tablets
PDSP1_001016
PDSP1_001235
PDSP2_001000
PDSP2_001219
Passauer Brand of Caffeine
Pep-Back
Percoffedrinol N
Percutafeine
Phensal
Pierre Fabre Brand of Caffeine
Probes1_000150
Probes2_000128
Propoxyphene
Propoxyphene Compound 65
Propoxyphene Compound-65
Quick Pep
Quick-Pep
Refresh'n
Republic Drug Brand of Caffeine
SDCCGMLS-0064595.P001
SDCCGMLS-0064595.P002
SK 65 Compound
SK-65 Compound
SMR000326667
SPBio_001222
SPECTRUM1500155
STK177283
Seid Brand of Caffeine
Spectrum2_001261
Spectrum3_000321
Spectrum4_001782
Spectrum5_000423
Spectrum_001301
Stim
Synalgos-Dc
TNP00310
Thein
Theine
Theobromine ME
Theobromine Me
Theophylline ME
Theophylline Me
Theophylline, 7-methyl
Thompson Brand 1 of Caffeine
Thompson Brand 2 of Caffeine
Tirend
Tri-Aqua
Triad
UNII-3G6A5W338E
Ultra Pep-Back
Vivarin
W222402_ALDRICH
WLN: T56 BN DN FNVNVJ B1 F1 H1
Wake-Up
Wigraine
Xanthine, 1,3,7-trimethyl
ZINC00001084
bmse000206
cafeine
caffeine
caffenium
component of Cafergot
nchembio.243-comp7
nchembio.63-comp5
nchembio774-comp2
teina
teína
11
Vitamin Aapproved, nutraceutical, vet_approvedPhase 4, Phase 346811103-57-4, 68-26-8445354
Synonyms:
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
.alpha.lin
.alpha.sterol
.beta.-Retinol
11103-57-4
13123-33-6
1341-18-0
1406-67-3
17104-91-5
1rbp
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclchexen-1-yl)-2,4,6,8-nonatetraen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonate-traen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraen-1-ol
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer
4-06-00-04133 (Beilstein Handbook Reference)
53637-36-8
5979-23-7
68-26-8
95144_FLUKA
95144_SIGMA
95146_FLUKA
95146_SIGMA
A-Mulsal
A-Sol
A-Vi-Pel
A-Vitan
AC-11701
AC1L9HU3
AC1Q7BU9
ACON
ALL-TRANS RETINOL (SEE ALSO RETINOID PROJECT 1)
AR-1L3057
ATAV
Afaxin
Agiolan
Agoncal
Alcohol 9,13-dimethyl-7-(1,1,5-trimethyl-6-cyclohexen-5-yl)-7,9,11,13-nonatetraen-15-ol
Alcovit A
All Trans Retinol
All-trans retinol
All-trans-Retinol
Alphalin
Alphasterol
Anatola
Anatola A
Anti-infective vitamin
Antixerophthalmic vitamin
Antixerophthalmisches Vitamin
Aoral
Apexol
Apostavit
Aquasol A Parenteral
Aquasynth
Atars
Avibon
Avita
Avitol
Axerol
Axerophthol
Axerophtholum
BIDD:PXR0102
BRN 0403040
Bentavit A
Biosterol
C00473
C17276
C20H30O
CCRIS 5444
CHEBI:17336
CHEMBL986
CID445354
Chocola A
Cylasphere
D014801
D06543
DB00162
Del-VI-A
Disatabs Tabs
Dofsol
Dohyfral A
EINECS 200-683-7
EINECS 234-328-2
Epiteliol
HMS1921B04
HMS2092L13
HMS501I08
HSDB 815
Hi-A-Vita
Homagenets Aoral
Homagenets aorl
Hydrovit A
IDI1_000486
LMPR01090001
LPK
LS-1578
Lard Factor
M.V.C. 9+3
M.V.I.-12
 
MLS001066379
MLS001074751
MolPort-001-785-962
Mvc Plus
Myvpack
NCGC00091784-01
NCGC00091784-02
NCGC00091784-03
NCGC00091784-04
NCGC00091784-05
NCGC00091784-06
NSC 122759
NSC122759
Nio-A-Let
Oleovitamin A
Ophthalamin
Plivit A
Prepalin
R7632_SIGMA
Retin-11,12-t2-ol (9CI)
Retinol
Retinol [INN:BAN]
Retinol solution
Retinol, all-trans- (8CI)
Retinol-(cellular-retinol-binding-protein)
Retinolo
Retinolo [DCIT]
Retinolum
Retinolum [INN-Latin]
Retrovitamin A
Ro-a-vit
Rovimix A 500
SDCCGMLS-0066724.P001
SMP2_000102
SMR000112036
SPECTRUM1501203
ST057232
Sehkraft A
Solu-A
Spectrum5_000993
Spectrum5_001997
Super A
Testavol
Testavol S
Thalasphere
UNII-81G40H8B0T
UNII-G2SH0XKK91
Vaflol
Vafol
Veroftal
Vi-.alpha.
Vi-Alpha
Vi-Dom-A
Vi-a
Vio-A
Vitamin A
Vitamin A (Feed)
Vitamin A (USP)
Vitamin A alcohol
Vitamin A alcohol (VAN)
Vitamin A cryst
Vitamin A1
Vitamin A1 alcohol
Vitamin A1 alcohol, all trans
Vitamin- A
Vitamin- A alcohol
Vitamin- A alcohol solution
Vitamin- A1
Vitamin-?A
Vitamin-?A alcohol
Vitamin-?A alcohol solution
Vitamin-?A1
Vitamine A
Vitaminum A
Vitavel A
Vitavel-A
Vitpex
Vogan
Vogan-Neu
Vogan-nu
WLN: L6UTJ A1 B1U1Y1&U2U1Y1&U2Q C1 C1
Wachstumsvitamin
ZINC03831417
Zinosan N
[11,12-3H]-Retinol
alin
all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
all-trans-Retinol
all-trans-Retinyl alcohol
all-trans-Vitamin A
all-trans-Vitamin A alcohol
all-trans-Vitamin A1
all-trans-retinol
all-trans-retinyl alcohol
all-trans-vitamin A alcohol
b-Retinol
beta-Retinol
retinol
tROL
trans-Retinol
trans-Retinol acid (Vitamin A)
trans-Vitamin A alcohol
trans-retinol
12AnticoagulantsPhase 4, Phase 22516
13MicronutrientsPhase 4, Phase 3, Phase 25802
14Retinol palmitatePhase 4, Phase 3468
15Protective AgentsPhase 4, Phase 3, Phase 2, Phase 17190
16Trace ElementsPhase 4, Phase 3, Phase 25802
17Central Nervous System StimulantsPhase 4, Phase 3, Phase 22132
18Angiogenesis InhibitorsPhase 4, Phase 2, Phase 3, Phase 14143
19Angiogenesis Modulating AgentsPhase 4, Phase 2, Phase 3, Phase 14072
20Respiratory System AgentsPhase 4, Phase 2, Phase 3, Phase 14818
21AnalgesicsPhase 4, Phase 3, Phase 211287
22Purinergic P1 Receptor AntagonistsPhase 4, Phase 3, Phase 2348
23Phosphodiesterase InhibitorsPhase 4, Phase 3, Phase 21254
24Calcium, DietaryPhase 4, Phase 3, Phase 25525
25AntioxidantsPhase 4, Phase 3, Phase 2, Phase 12928
26Chelating AgentsPhase 4, Phase 21365
27Caffeine citratePhase 4, Phase 3, Phase 218
28VitaminsPhase 4, Phase 3, Phase 25095
29Ketorolac TromethaminePhase 4, Phase 2304
30Pulmonary SurfactantsPhase 4, Phase 3, Phase 2107
31AnestheticsPhase 4, Phase 2, Phase 39001
32Cyclooxygenase InhibitorsPhase 4, Phase 3, Phase 22778
33Antirheumatic AgentsPhase 4, Phase 3, Phase 210627
34Analgesics, Non-NarcoticPhase 4, Phase 3, Phase 26260
35Anti-Inflammatory AgentsPhase 4, Phase 3, Phase 2, Phase 110355
36Anti-Inflammatory Agents, Non-SteroidalPhase 4, Phase 3, Phase 24295
37Central Nervous System DepressantsPhase 4, Phase 312806
38Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 2, Phase 122776
39Neurotransmitter AgentsPhase 4, Phase 2, Phase 3, Phase 117734
40Neuromuscular Blocking AgentsPhase 4414
41MitogensPhase 4, Phase 1, Phase 21526
42Hypnotics and SedativesPhase 42485
43Excitatory Amino AcidsPhase 41297
44Endothelial Growth FactorsPhase 4, Phase 1, Phase 2362
45Tocolytic AgentsPhase 4, Phase 3708
46Anti-Infective AgentsPhase 4, Phase 3, Phase 1, Phase 221402
47Platelet Aggregation InhibitorsPhase 4, Phase 32419
48Anesthetics, IntravenousPhase 42406
49Anesthetics, DissociativePhase 4507
50Excitatory Amino Acid AntagonistsPhase 41282

Interventional clinical trials:

(show top 50)    (show all 176)
idNameStatusNCT IDPhase
1Efficient Study of ACULAR in Inhibiting Proliferative Retinopathy in PrematurityUnknown statusNCT00634972Phase 4
2Withholding Feeds During Red Blood Cell Transfusion and TRAGIUnknown statusNCT02132819Phase 4
3Cpap at Delivery Room for Preterm InfantsUnknown statusNCT01024361Phase 4
4Early CPAP in Respiratory Distress SyndromeUnknown statusNCT00368680Phase 4
5Sucrose Analgesia for the Reduction of Pain During Retinopathy of Prematurity ScreeningCompletedNCT00921544Phase 4
6Anesthesia for Retinopathy of PrematurityCompletedNCT01955135Phase 4
7Vascular Endothelial Growth Factor in Stage V ROPCompletedNCT00500396Phase 4
8VEGF Levels in Aqueous, Vitreous and Subretinal Fluid in ROP Stage IV and VCompletedNCT00563121Phase 4
9Vitamin A and Very Low Birthweight Babies (VitAL)CompletedNCT00417404Phase 4
10Early Versus Late Lactoferrin in Prevention of Neonatal SepsisCompletedNCT02959229Phase 4
11MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose CaffeineCompletedNCT00809055Phase 4
12Safety and Tolerability of Ranibizumab in Patients With Subfoveal Choroidal Neovascularization Secondary to Age-related Macular DegenerationCompletedNCT00504959Phase 4
13OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAPRecruitingNCT02140580Phase 4
14Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature BabiesWithdrawnNCT00470743Phase 4
15Antiangiogenic Therapy With Bevacizumab in Retinopathy of Prematurity. Structural OutcomeUnknown statusNCT00346814Phase 2, Phase 3
16The Early Treatment for Retinopathy of Prematurity Study (ETROP)Unknown statusNCT00027222Phase 2, Phase 3
17Oral Vitamin A Supplementation in Neonates With Birth Weight < 1500 gUnknown statusNCT02102711Phase 3
18Randomized Study of Pessary Versus Standard Management in Women With Increased Chance of Premature BirthUnknown statusNCT00735137Phase 3
19Cysteine Supplementation in Critically Ill NeonatesUnknown statusNCT00254176Phase 2, Phase 3
20A Fatty Acids Study in Preventing Retinopathy of PrematurityCompletedNCT02760472Phase 3
21Safety and Efficacy of Propranolol in Newborns With Retinopathy of PrematurityCompletedNCT01079715Phase 2, Phase 3
22The Effects of Light Reduction on Retinopathy of Prematurity (Light-ROP)CompletedNCT00000156Phase 3
23Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of PrematurityCompletedNCT01203436Phase 2, Phase 3
24Inhaled Nitrous Oxide for Pain Relief During Eye Exam in the Pre-term InfantCompletedNCT00623220Phase 3
25Premature Infants in Need of Transfusion (PINT)CompletedNCT00182390Phase 3
26Oxygen Toxicity in the Resuscitation in Extremely Premature InfantsCompletedNCT00494702Phase 3
27Inhaled Nitric Oxide to Prevent and Treat Bronchopulmonary DysplasiaCompletedNCT01503801Phase 2, Phase 3
2817OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet PregnanciesCompletedNCT00163020Phase 2, Phase 3
29Caffeine for Apnea of Prematurity (CAP)CompletedNCT00182312Phase 3
30Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)CompletedNCT00009646Phase 3
31NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome)CompletedNCT02259400Phase 2, Phase 3
32Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams BirthweightCompletedNCT00734539Phase 3
33Canadian Oxygen Trial (COT)CompletedNCT00637169Phase 3
34Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)CompletedNCT00433212Phase 3
35Omega-3 Fatty Acid Supplementation to Prevent Preterm Birth in High Risk PregnanciesCompletedNCT00135902Phase 3
36High Versus Low Dose of Caffeine for Apnea of PrematurityCompletedNCT02103777Phase 3
37Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth WeightCompletedNCT00114543Phase 3
38Pentoxifylline and Late Onset Sepsis in Preterm InfantsCompletedNCT02163174Phase 3
39Safety and Efficacy Study of Ibuprofen l-Lysine Solution in Premature Infants for Treatment of PDACompletedNCT00440804Phase 3
40High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia PreventionCompletedNCT01355159Phase 3
41Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS)CompletedNCT00099164Phase 3
42Prevention Trial of Nosocomial Infections in Neutropenic Prematures With G-CSFCompletedNCT00213759Phase 3
43RAINBOW Study: RAnibizumab Compared With Laser Therapy for the Treatment of INfants BOrn Prematurely With Retinopathy of PrematurityRecruitingNCT02375971Phase 3
44Rainbow Extension StudyRecruitingNCT02640664Phase 3
45Sildenafil Therapy In Dismal Prognosis Early-Onset Intrauterine Growth RestrictionRecruitingNCT02442492Phase 2, Phase 3
46Dose Reduction of Antenatal Betamethasone Given to Prevent the Neonatal Complications Associated With Very Preterm BirthRecruitingNCT02897076Phase 3
47A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV)RecruitingNCT01376778Phase 3
48Maternal Omega-3 Supplementation to Reduce Bronchopulmonary DysplasiaRecruitingNCT02371460Phase 3
49Comparison of Two Flow Rates of HHHFNC to Prevent Extubation Failure in Preterm InfantsRecruitingNCT02681315Phase 3
50Surfactant Positive Airway Pressure and Pulse Oximetry TrialActive, not recruitingNCT00233324Phase 3

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Cochrane evidence based reviews: retinopathy of prematurity

Genetic Tests for Exudative Vitreoretinopathy 1

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Genetic tests related to Exudative Vitreoretinopathy 1:

id Genetic test Affiliating Genes
1 Exudative Vitreoretinopathy 127
2 Retinopathy of Prematurity27 24 FZD4
3 Familial Exudative Vitreoretinopathy, Autosomal Dominant27 24 FZD4, LRP5, TSPAN12

Anatomical Context for Exudative Vitreoretinopathy 1

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MalaCards organs/tissues related to Exudative Vitreoretinopathy 1:

36
Eye, Retina, Lung, Skin, Endothelial, Testes, Liver

Publications for Exudative Vitreoretinopathy 1

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Variations for Exudative Vitreoretinopathy 1

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UniProtKB/Swiss-Prot genetic disease variations for Exudative Vitreoretinopathy 1:

70 (show all 23)
id Symbol AA change Variation ID SNP ID
1FZD4p.Met105ValVAR_038947rs80358284
2FZD4p.Met157ValVAR_038948rs80358286
3FZD4p.Gly36AspVAR_063921rs80358281
4FZD4p.Glu40GlnVAR_063922rs139401671
5FZD4p.His69TyrVAR_063923rs80358282
6FZD4p.Met105ThrVAR_063924rs80358285
7FZD4p.Ile114ThrVAR_063925
8FZD4p.Cys181ArgVAR_063927rs80358287
9FZD4p.Cys204ArgVAR_063929rs80358288
10FZD4p.Cys204TyrVAR_063930
11FZD4p.Met223LysVAR_063931
12FZD4p.Ile256ValVAR_063932rs104894223
13FZD4p.Trp335CysVAR_063933rs80358292
14FZD4p.Met342ValVAR_063934rs80358293
15FZD4p.Arg417GlnVAR_063936rs80358294
16FZD4p.Thr445ProVAR_063937rs80358297
17FZD4p.Gly488AspVAR_063938rs80358298
18FZD4p.Ser497PheVAR_063939rs80358300
19FZD4p.Gly525ArgVAR_063940
20LRP5p.Arg348TrpVAR_063948
21LRP5p.Asp381AsnVAR_076548
22LRP5p.Arg624TrpVAR_076549
23LRP5p.Tyr1517CysVAR_076550rs201030241

Clinvar genetic disease variations for Exudative Vitreoretinopathy 1:

5
id Gene Variation Type Significance SNP ID Assembly Location
1FZD4NM_012193.3(FZD4): c.1479_1484delGTGGAT (p.Met493_Trp494del)deletionPathogenicrs80358301GRCh37Chr 11, 86662314: 86662319
2FZD4NM_012193.3(FZD4): c.1501_1502delCT (p.Leu501Serfs)deletionPathogenicrs80358303GRCh37Chr 11, 86662296: 86662297
3FZD4NM_012193.3(FZD4): c.1250G> A (p.Arg417Gln)SNVPathogenicrs80358294GRCh37Chr 11, 86662548: 86662548
4FZD4NM_012193.3(FZD4): c.1024A> G (p.Met342Val)SNVPathogenicrs80358293GRCh37Chr 11, 86662774: 86662774
5FZD4NM_012193.3(FZD4): c.1005G> C (p.Trp335Cys)SNVPathogenicrs80358292GRCh37Chr 11, 86662793: 86662793
6FZD4NM_012193.3(FZD4): c.766A> G (p.Ile256Val)SNVPathogenicrs104894223GRCh37Chr 11, 86663032: 86663032

Expression for genes affiliated with Exudative Vitreoretinopathy 1

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Search GEO for disease gene expression data for Exudative Vitreoretinopathy 1.

Pathways for genes affiliated with Exudative Vitreoretinopathy 1

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GO Terms for genes affiliated with Exudative Vitreoretinopathy 1

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Cellular components related to Exudative Vitreoretinopathy 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.7CD38, DEFB127, EPO, FZD4, NDP, TEK
2extracellular spaceGO:00056159.0ANGPT2, EPO, FLT1, IGF1, NDP, SERPINH1

Biological processes related to Exudative Vitreoretinopathy 1 according to GeneCards Suite gene sharing:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1retinal blood vessel morphogenesisGO:006130410.9FZD4, LRP5
2cell migration involved in sprouting angiogenesisGO:000204210.9KDR, VEGFA
3positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayGO:003803310.9KDR, VEGFA
4positive regulation of positive chemotaxisGO:005092710.9KDR, VEGFA
5negative regulation of cell-substrate adhesionGO:001081210.9ANGPT2, FZD4
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.8EPO, IGF1
7canonical Wnt signaling pathwayGO:006007010.8FZD4, LRP5, NDP
8extracellular matrix-cell signalingGO:003542610.8FZD4, LRP5, NDP
9cellular response to electrical stimulusGO:007125710.8HIF1A, IGF1
10positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:006141910.8HIF1A, VEGFA
11embryonic hemopoiesisGO:003516210.8HIF1A, KDR
12hemoglobin biosynthetic processGO:004254110.8EPO, HIF1A
13positive regulation of sequence-specific DNA binding transcription factor activityGO:005109110.8FZD4, LRP5, NDP
14positive regulation of glycolytic processGO:004582110.8HIF1A, IGF1
15retina vasculature morphogenesis in camera-type eyeGO:006129910.8FZD4, LRP5, NDP
16response to salt stressGO:000965110.7EPO, HIF1A
17cellular response to vascular endothelial growth factor stimulusGO:003592410.7FLT1, KDR, VEGFA
18lactationGO:000759510.6ATP7B, HIF1A, VEGFA
19positive regulation of MAPK cascadeGO:004341010.6FLT1, IGF1, KDR
20positive regulation of endothelial cell migrationGO:001059510.6KDR, TEK, VEGFA
21positive regulation of focal adhesion assemblyGO:005189410.6KDR, TEK, VEGFA
22Tie signaling pathwayGO:004801410.6ANGPT2, TEK
23regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:006141810.6EPO, HIF1A, VEGFA
24positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:003094910.5FLT1, HIF1A, VEGFA
25positive regulation of smooth muscle cell proliferationGO:004866110.5FLT1, HIF1A, IGF1
26blood vessel morphogenesisGO:004851410.5ANGPT2, FLT1, HIF1A
27response to estrogenGO:004362710.5EPO, HIF1A, TEK
28positive regulation of cell migrationGO:003033510.5FLT1, IGF1, KDR, VEGFA
29positive regulation of phosphatidylinositol 3-kinase signalingGO:001406810.4FLT1, IGF1, KDR, TEK
30vascular endothelial growth factor receptor signaling pathwayGO:004801010.3FLT1, KDR, VEGFA
31transmembrane receptor protein tyrosine kinase signaling pathwayGO:000716910.3FLT1, KDR, TEK
32positive regulation of endothelial cell proliferationGO:000193810.3HIF1A, KDR, TEK, VEGFA
33positive regulation of cell proliferationGO:000828410.1EPO, FLT1, IGF1, KDR, LRP5, VEGFA
34vasculogenesisGO:000157010.0FZD4, KDR, VEGFA
35positive regulation of angiogenesisGO:00457669.9ANGPT2, FLT1, HIF1A, KDR, TEK, VEGFA
36negative regulation of apoptotic processGO:00430669.7CD38, EPO, HIF1A, IGF1, KDR, TEK
37angiogenesisGO:00015259.7ANGPT2, FLT1, HIF1A, KDR, TEK, TSPAN12
38positive regulation of transcription, DNA-templatedGO:00458939.7CD38, CDKN1C, EPO, FZD4, HIF1A, IGF1
39signal transductionGO:00071659.5ANGPT2, CD38, EPO, HIF1A, IGF1, NDP
40response to hypoxiaGO:00016669.4ANGPT2, CD38, EPO, FLT1, HIF1A, IGF1

Molecular functions related to Exudative Vitreoretinopathy 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor bindingGO:001983810.6FLT1, KDR, TEK
2vascular endothelial growth factor-activated receptor activityGO:000502110.4FLT1, KDR
3transmembrane receptor protein tyrosine kinase activityGO:000471410.2FLT1, KDR, TEK
4Wnt-activated receptor activityGO:004281310.0FZD4, LRP5, TSPAN12
5protein bindingGO:00055157.2ANGPT2, ATP7B, CDKN1C, DEFB127, EPO, FLT1

Sources for Exudative Vitreoretinopathy 1

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet