EVR1
MCID: EXD008
MIFTS: 59

Exudative Vitreoretinopathy 1 (EVR1) malady

Categories: Genetic diseases, Rare diseases, Eye diseases, Neuronal diseases, Cardiovascular diseases

Aliases & Classifications for Exudative Vitreoretinopathy 1

About this section
Sources:
11Disease Ontology, 13DISEASES, 23GeneReviews, 24GeneTests, 27GTR, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 37MedGen, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 52OMIM, 54Orphanet, 62SNOMED-CT, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet, 70UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Exudative Vitreoretinopathy 1:

Name: Exudative Vitreoretinopathy 1 52 68
Retinopathy of Prematurity 52 11 48 24 54 27 39 13 68
Retrolental Fibroplasia 11 48 54
Familial Exudative Vitreoretinopathy, Autosomal Dominant 23 24
Autosomal Dominant Familial Exudative Vitreoretinopathy 70 27
Vitreoretinopathy, Exudative 1 70 27
 
Adfevr 23 24
Rop 48 54
Criswick-Schepens Syndrome 70
Premature Retinopathy 11
Fevr 70
Evr1 70

Characteristics:

Orphanet epidemiological data:

54
retinopathy of prematurity:
Age of onset: Infancy,Neonatal; Age of death: normal life expectancy

HPO:

64
exudative vitreoretinopathy 1:
Inheritance: autosomal dominant inheritance
Onset and clinical course: infantile onset, slow progression

GeneReviews:

23
Penetrance: when using fluorescein angiography to determine clinical status, penetrance is reported to be 100% because all affected individuals have a sector of avascular peripheral retina [ober et al 1980]. ...


Classifications:

Orphanet: 54 
Rare eye diseases


External Ids:

OMIM52 133780
Disease Ontology11 DOID:13025
ICD9CM32 362.20, 362.21
MeSH39 D012178
NCIt45 C34982
Orphanet54 ORPHA90050
UMLS via Orphanet69 C0035344
MESH via Orphanet40 D012178
ICD10 via Orphanet31 H35.1

Summaries for Exudative Vitreoretinopathy 1

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OMIM:52 Familial exudative vitreoretinopathy (FEVR) is an inherited disorder characterized by the incomplete development of the... (133780) more...

MalaCards based summary: Exudative Vitreoretinopathy 1, also known as retinopathy of prematurity, is related to fzd4-related familial exudative vitreoretinopathy, autosomal dominant and lrp5-related familial exudative vitreoretinopathy, autosomal dominant, and has symptoms including hyperoxia, hyperoxia and subcapsular cataract. An important gene associated with Exudative Vitreoretinopathy 1 is FZD4 (Frizzled Class Receptor 4), and among its related pathways are Primary Focal Segmental Glomerulosclerosis FSGS and Differentiation Pathway. Affiliated tissues include retina and eye, and related mouse phenotypes are pigmentation and respiratory system.

UniProtKB/Swiss-Prot:70 Vitreoretinopathy, exudative 1: A disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. Clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease related abnormality is an arc of avascular retina in the extreme temporal periphery. In many ways the disease resembles retinopathy of prematurity but there is no evidence of prematurity or small birth weight in the patient history.

GeneReviews for NBK1147

Related Diseases for Exudative Vitreoretinopathy 1

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Diseases in the Exudative Vitreoretinopathy family:

Exudative Vitreoretinopathy 5 Exudative Vitreoretinopathy 3
Exudative Vitreoretinopathy 6 Exudative Vitreoretinopathy 4
exudative vitreoretinopathy 1 Lrp5-Related Familial Exudative Vitreoretinopathy, Autosomal Recessive
Fzd4-Related Familial Exudative Vitreoretinopathy, Autosomal Dominant Lrp5-Related Familial Exudative Vitreoretinopathy, Autosomal Dominant
Tspan12-Related Familial Exudative Vitreoretinopathy, Autosomal Dominant

Diseases related to Exudative Vitreoretinopathy 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1fzd4-related familial exudative vitreoretinopathy, autosomal dominant12.2
2lrp5-related familial exudative vitreoretinopathy, autosomal dominant12.2
3tspan12-related familial exudative vitreoretinopathy, autosomal dominant12.2
4ndp-related retinopathy of prematurity12.0
5exudative vitreoretinopathy11.1
6exudative vitreoretinopathy 510.8
7microcephaly with or without chorioretinopathy, lymphedema, or mental retardation10.8
8exudative vitreoretinopathy 310.8
9exudative vitreoretinopathy 410.8
10exudative vitreoretinopathy 2, x-linked10.8
11microcephaly and chorioretinopathy, autosomal recessive, 110.7
12retinitis10.4
13endotheliitis10.4
14breast osteosarcoma10.3FZD4, NDP, TSPAN12
15kidney osteogenic sarcoma10.3FLT1, KDR, VEGFA
16cornea plana10.3FZD4, NDP, TSPAN12
17nystagmus 5, congenital, x-linked10.3FZD4, LRP5, NDP, TSPAN12
18astigmatism10.3FZD4, LRP5, NDP
19neuropathy with hearing impairment10.3FLT1, KDR, VEGFA
20vesiculobullous skin disease10.2KDR, TEK, VEGFA
21radiation induced angiosarcoma of the breast10.2ANGPT2, TEK, VEGFA
22localized junctional epidermolysis bullosa, non-herlitz type10.2ANGPT2, FLT1, VEGFA
23anterograde amnesia10.2FZD4, LRP5, NDP, TSPAN12, VEGFA
24neurilemmoma of the pleura10.2KDR, NRP1, VEGFA
25biemond syndrome ii10.2FZD4, KDR, NDP, TSPAN12, VEGFA
26epidermolysis bullosa simplex, sutosomal recessive 210.2ANGPT2, FLT1, IGF1, VEGFA
27subdural empyema10.2FLT1, KDR, TEK, VEGFA
28ovarian disease10.2FLT1, KDR, NRP1, VEGFA
29human granulocytic anaplasmosis10.2FLT1, KDR, TEK, VEGFA
30mitral valve stenosis10.2FLT1, KDR, VEGFA
31pulmonary blastoma10.2ANGPT2, FLT1, KDR, TEK
32hemangioma10.2
33skin hemangioma10.2
34van buchem disease, type 210.1CTNNB1, FZD4, LRP5, NDP
35thymus adenosquamous carcinoma10.1FLT1, IGF1, KDR, VEGFA
36pituitary infarct10.1ANGPT2, TEK, VEGFA
37vulvitis10.1ANGPT2, FLT1, KDR, TEK, VEGFA
38hemolytic anemia10.1ANGPT2, FLT1, KDR, TEK, VEGFA
39mental retardation, autosomal recessive 2710.1ANGPT2, KDR, VEGFA
40hypermethioninemia10.1CDKN1C, FZD4, LRP5, NDP, NRP1, TSPAN12
41citrullinemia, type ii, neonatal-onset10.1ANGPT2, FLT1, IGF1, KDR, TEK, VEGFA
42norrie disease10.0
43retinal detachment10.0
44refractive error10.0
45papillary craniopharyngioma10.0CTNNB1, IGF1, VEGFA
46oppositional defiant disorder10.0KDR, TEK, VEGFA
47retinoschisis10.0
48insulin-like growth factor i9.9
49choroiditis9.9
50vernal conjunctivitis9.9ANGPT2, FLT1, FZD4, IGF1, KDR, LRP5

Graphical network of the top 20 diseases related to Exudative Vitreoretinopathy 1:



Diseases related to exudative vitreoretinopathy 1

Symptoms & Phenotypes for Exudative Vitreoretinopathy 1

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Symptoms by clinical synopsis from OMIM:

133780

Clinical features from OMIM:

133780

Human phenotypes related to Exudative Vitreoretinopathy 1:

 64 (show all 13)
id Description HPO Frequency HPO Source Accession
1 subcapsular cataract64 HP:0000523
2 retinal detachment64 HP:0000541
3 blindness64 HP:0000618
4 pigmentary retinal degeneration64 HP:0001146
5 retinal exudate64 HP:0001147
6 posterior vitreous detachment64 HP:0001489
7 falciform retinal fold64 HP:0001493
8 recurrent fractures64 HP:0002757
9 reduced visual acuity64 HP:0007663
10 peripheral retinal avascularization64 HP:0007685
11 vitreous hemorrhage64 HP:0007902
12 exudative vitreoretinopathy64 HP:0030490
13 retinal neovascularization64 HP:0030666

UMLS symptoms related to Exudative Vitreoretinopathy 1:


hyperoxia

MGI Mouse Phenotypes related to Exudative Vitreoretinopathy 1 according to GeneCards Suite gene sharing:

41 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.5ATP7B, CTNNB1, FZD4, LRP5, NDP
2MP:00053889.9ANGPT2, CTNNB1, EPO, IGF1, KDR, SERPINH1
3MP:00107719.7ANGPT2, ATP7B, CTNNB1, EPO, FZD4, IGF1
4MP:00053809.5CTNNB1, EPO, FLT1, FZD4, KDR, LRP5
5MP:00053699.5ATP7B, CTNNB1, EPO, FLT1, FZD4, IGF1
6MP:00028739.4CTNNB1, EPO, FLT1, FZD4, IGF1, INPP5J
7MP:00053879.3ANGPT2, ATP7B, CD38, CTNNB1, EPO, FLT1
8MP:00053769.2ANGPT2, ATP7B, CD38, CTNNB1, EPO, FLT1
9MP:00053979.2ATP7B, CD38, CTNNB1, EPO, FLT1, FZD4
10MP:00036319.1ATP7B, CTNNB1, FLT1, FZD4, IGF1, KDR
11MP:00053849.0ANGPT2, ATP7B, CD38, CTNNB1, EPO, FLT1
12MP:00053858.8ANGPT2, CTNNB1, EPO, FLT1, FZD4, IGF1
13MP:00107688.7ANGPT2, ATP7B, CPVL, CTNNB1, EPO, FLT1
14MP:00053918.5ANGPT2, CTNNB1, FLT1, FZD4, KDR, LRP5

Drugs & Therapeutics for Exudative Vitreoretinopathy 1

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Drugs for Exudative Vitreoretinopathy 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 220)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
KetorolacapprovedPhase 4, Phase 232374103-06-3, 66635-83-43826
Synonyms:
(+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
(+-)-Ketorolac
(+-)-isomer
(.+/-.)-2,3-Dihydro-5-benzoyl-1H-pyrrolizine-1-carboxylic acid
1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro
5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
5-Benzoyl-1,2-dihydro-3H-pyrrolo(1,2a)pyrrole-1-carboxylic acid
5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
66635-83-4
74103-06-3
AB00053682
AC-545
AC1L1GSW
BRD-A40639672-234-05-7
C07062
CHEBI:105080
CHEMBL469
CID3826
D020910
D08104
DB00465
 
I14-2832
Ketoralac
Ketorolac
Ketorolac (INN)
Ketorolac Tromethamine
Ketorolac [INN:BAN]
Ketorolaco
Ketorolaco [Spanish]
Ketorolacum
Ketorolacum [Latin]
Kétorolac
LS-139094
Macril
MolPort-005-933-093
NCGC00185990-01
RS 37619
RS-37619
SBB067312
STL018674
Toradol (TN)
UNII-YZI5105V0L
ketorolac
rac-Ketorolac
2Poractant alfaapprovedPhase 426129069-19-8
3
Bevacizumabapproved, investigationalPhase 4, Phase 2, Phase 3, Phase 12020216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
4
Sevofluraneapproved, vet_approvedPhase 450828523-86-65206
Synonyms:
1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
28523-86-6
AC-15484
AC1L1JU0
BRN 2041023
Bax 3084
C009250
C07520
C4H3F7O
CHEBI:9130
CHEMBL1200694
CID5206
D00547
DB01236
F0691
Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether
Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
I14-13357
LS-67851
MR6S4
 
MR_6S4
MolPort-001-775-746
NCGC00167421-01
PC4681
Sevofluran
Sevoflurane
Sevoflurane (JAN/USAN/INN)
Sevoflurane [USAN:INN:BAN:JAN]
Sevoflurano
Sevoflurano [INN-Spanish]
Sevofluranum
Sevofluranum [INN-Latin]
Sevofrane
Sevorane
Sojourn
UNII-38LVP0K73A
Ultane
Ultane (TN)
ZINC01530810
fluoromethyl hexafluoroisopropyl ether
fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
sevoflurane
5
Nitrous oxideapproved, vet_approvedPhase 4, Phase 318110024-97-2948
Synonyms:
00583_FLUKA
10024-97-2
126386-65-0
129451-49-6
130835-71-1
147527-07-9
175876-44-5
295590_ALDRICH
794457-85-5
847968-13-2
850203-00-8
AC1L1ADZ
C00887
CCRIS 1225
CHEBI:17045
CHEMBL1234579
CID948
D00102
D009609
Diazyne 1-oxide
Dinitrogen monoxide
Dinitrogen oxide
Distickstoffmonoxid
E942
EINECS 233-032-0
FEMA 2779
FEMA No. 2779
Factitious air
Gas, Laughing
Gas, laughing
Gaz hilarant
HSDB 504
Hyponitrous acid anhydride
LS-7622
Lachgas
Laughing gas
N2O
NITROUS-OXIDE
NNO
 
Nitral
Nitrious oxide
Nitrogen hypoxide
Nitrogen monoxide
Nitrogen oxide (N2O)
Nitrogen protoxide
Nitrogenium oxydulatum
Nitrous oxide
Nitrous oxide (JP15/USP)
Nitrous oxide (TN)
Nitrous oxide [Anaesthetics, volatile]
Nitrous oxide [JAN]
Nitrous oxide [UN1070] [Nonflammable gas]
Nitrous oxide [UN1070] [Nonflammable gas]
Nitrous oxide [anaesthetics, volatile]
Nitrous oxide [jan]
Nitrous oxide, JAN, USAN
Nitrous oxide, compressed
Nitrous oxide, refrigerated liquid
Nitrous oxide, refrigerated liquid [UN2201] [Nonflammable gas]
Nitrous oxide, refrigerated liquid [UN2201] [Nonflammable gas]
Nitrous-oxide
Oxide, Nitrous
Oxide, nitrous
Oxido nitroso
Oxido nitroso [Spanish]
Oxidodinitrogen(N--N)
Oxyde nitreux
Protoxyde d'azote [French]
Stickdioxyd
Stickdioxyd [German]
Stickstoff(I)-oxid
UN1070
UN2201
gaz hilarant
nitrogenium oxydulatum
nitrous oxide
oxidodinitrogen(N--N)
oxyde nitreux
protoxyde d'azote
6
RanibizumabapprovedPhase 4, Phase 3, Phase 2486347396-82-1459903
Synonyms:
347396-82-1
D05697
Lucentis
Lucentis (TN)
 
Ranibizumab
Ranibizumab (USAN/INN)
Ranibizumab (genetical recombination)
Ranibizumab (genetical recombination) (JAN)
ranibizumab
rhuFab V2
7
Ketamineapproved, vet_approvedPhase 45696740-88-13821
Synonyms:
(+-)-Ketamine
(+/-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
(+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
(+/-)-Ketamine
(-)-Ketamine
(S)-(-)-Ketamine
(S)-Ketamine
(±)-ketamine
100477-72-3
2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone
2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
2-(Methylamino)-2-(2-chlorophenyl)cyclohexanone
2-(methylamino)-2-(2-chlorophenyl)cyclohexanone
2-(o-Chlorophenyl)-2-(methylamino)-cyclohexanone
2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(o-chlorophenyl)-2-(methylamino)-cyclohexanone
33643-45-7
6740-88-1
79499-51-7
AC1L1GSH
AC1Q40UR
AKOS001053247
BRN 2216965
C07525
C13H16ClNO
CHEBI:138833
CHEBI:6121
CHEMBL742
CI 581 base
CI-581
CID3821
CLSTA 20
Calypsol
Cetamina
Cetamina [INN-Spanish]
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)- (9CI)
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)- (9CI)
Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+/-)- (8CI)
D08098
DB01221
 
DEA No. 7285
DL-ketamine
DivK1c_000217
EINECS 229-804-1
Esketamine
Green
IDI1_000217
KBio1_000217
KETAMINE HCL
Ketaject
Ketalar
Ketalar base
Ketamina
Ketamine (INN)
Ketamine Base
Ketamine HCL
Ketamine [INN:BAN]
Ketaminum
Ketaminum [INN-Latin]
Ketanest
Ketoject
Ketolar
Kétamine
L-Ketamine
LS-57301
MLS001331674
MolPort-001-838-070
NCGC00159480-02
NCGC00159480-03
NINDS_000217
NMDA
NSC 70151
NSC70151
SMR000238141
Special K
Special K [street name]
T385
Tekam
Tekam (TN)
UNII-690G0D6V8H
dl-Ketamine
ketamine
l-Ketamine
8
Propofolapproved, investigational, vet_approvedPhase 410822078-54-84943
Synonyms:
2, 6-Diisopropylphenol
2,6 Diisopropylphenol
2,6-Bis(1-methylethyl)phenol
2,6-Bis(Isopropyl)-phenol
2,6-DIISOPROPYLPHENOL
2,6-Diisopropyl phenol
2,6-Diisopropylphenol
2,6-bis(1-methylethyl)-phenol
2,6-di(propan-2-yl)phenol
2078-54-8
28449-97-0
4-06-00-03435 (Beilstein Handbook Reference)
50356-15-5
AB00513968
AC-2038
AC1L1J9Y
AC1Q1OUI
AI3-26295
AM-149
Abbott Brand of Propofol
Alpha Brand of Propofol
Ampofol
Aquafol
Astra Brand of Propofol
AstraZeneca Brand of Propofol
BIDD:GT0436
BPBio1_000950
BPBio1_000969
BRD-K82255054-001-03-5
BRN 1866484
BSPBio_000862
Biomol-NT_000248
Braun Brand of Propofol
C07523
C12H18O
CAS-2078-54-8
CCRIS 9000
CHEBI:44915
CHEMBL526
CID4943
CPD-11437
CPD000059151
Curamed Brand of Propofol
D00549
D015742
D0617
D126608
D126608_ALDRICH
DB00818
DDS-04F
Diisopropylphenol
Dipravan
Diprivan
Diprivan (TN)
Diprivan Injectable emulsion
Disoprivan
Disoprofol
EINECS 218-206-6
EU-0100437
Fresenius Brand of Propofol
Fresenius Kabi Brand of Propofol
Fresofol
HMS1570L04
HMS2089O21
HMS2094E17
 
HSDB 7123
ICI 35,868
ICI 35868
ICI-35,868
ICI-35868
ICI35,868
ICI35868
InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H
Ivofol
Jsp004266
Juste Brand of Propofol
LS-996
Lopac-D126608
Lopac0_000437
MLS001066348
MLS001335999
MLS002454360
MolPort-001-794-517
NCGC00015389-01
NCGC00015389-02
NCGC00015389-04
NCGC00015389-09
NCGC00091538-01
NCGC00091538-02
NCGC00091538-03
NCGC00091538-04
NCGC00091538-05
NCGC00091538-06
NSC 5105
NSC5105
PFL
Parnell Brand of Propofol
Pisa Brand of Propofol
Prestwick0_000931
Prestwick1_000931
Prestwick2_000931
Prestwick3_000931
Propofol
Propofol (JAN/USAN/INN)
Propofol Abbott
Propofol Fresenius
Propofol IDD-D
Propofol MCT
Propofol Rovi
Propofol [USAN:INN:BAN]
Propofol(2,6-Diisopropylphenol)
Propofol-Lipuro
Propofolum
Propofolum [Latin]
Rapinovet
Recofol
Rovi Brand of Propofol
S01-0189
SAM002264610
SMR000059151
SPBio_003031
SPECTRUM1505022
ST50405911
Schering Brand of Propofol
UNII-YI7VU623SF
W505102_ALDRICH
ZD-0859
ZINC00968303
Zeneca Brand of Propofol
ghl.PD_Mitscher_leg0.558
nchembio.552-comp7
propofol
9
Indomethacinapproved, investigationalPhase 4, Phase 311653-86-13715
Synonyms:
1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
1z9h
37242-43-6
503560-73-4
53-86-1
74252-25-8 (hydrochloride salt, tri-hydrate)
7681-54-1 (hydrochloride salt)
91853-74-6
AB00052022
AC-532
AC1L1GJQ
AKOS000592893
Aconip
Aconip (TN)
Amuno
Apo-Indomethacin
Arthrexin
Artracin
Artrinovo
Artrivia
BIDD:GT0132
BIM-0050670.0001
BPBio1_000160
BRD-K57222227-001-06-1
BRN 0497341
BSPBio_000144
BSPBio_001149
BSPBio_002176
Bio-0704
Bio2_000405
Bio2_000885
Bonidin
Bonidon
Bonidon Gel
C01926
CAS-53-86-1
CCRIS 3502
CHEBI:49662
CHEMBL6
CID3715
CPD-10545
Catlep
Chibro-amuno
Chrono-indicid
Chrono-indocid
Confortid
D00141
DB00328
DESMETHYL INDOMETHACIN
DivK1c_000271
Dolcidium
Dolcidium PL
Dolovin
Durametacin
EINECS 200-186-5
EU-0100692
Elmetacin
Flexin continus
HMS1362I11
HMS1568H06
HMS1792I11
HMS1920F21
HMS1990I11
HMS2089N19
HMS2091N09
HMS500N13
HSDB 3101
Hicin
I 7378
I0655
I7378_SIGMA
I8280_SIGMA
IDI1_000271
IDI1_002160
IMN
IN1454
Idomethine
Imbrilon
Inacid
Indacin
Indameth
Indmethacine
Indo-Lemmon
Indo-Spray
Indo-phlogont
Indo-rectolmin
Indo-tablinen
Indocid
Indocid (pharmaceutical)
Indocid Pda
Indocid Sr
Indocin
Indocin (TN)
Indocin I.V
Indocin I.V.
Indocin Sr
Indolar SR
Indomecol
Indomed
Indomee
Indomet 140
Indometacin
Indometacin (JP15/INN)
Indometacina
Indometacina [INN-Spanish]
Indometacine
Indometacine [INN-French]
Indometacinum
 
Indometacinum [INN-Latin]
Indometacyna
Indometacyna [Polish]
Indomethacin
Indomethacin & MAP-30
Indomethacin (USP)
Indomethacin [USAN:BAN]
Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin
Indomethacine
Indomethacinum
Indomethancin
Indomethazine
Indomethegan
Indomethine
Indometicina
Indometicina [Spanish]
Indomo
Indomod
Indoptic
Indoptol
Indorektal
Indoxen
Inflazon
Infrocin
Inteban sp
KBio1_000271
KBio2_000489
KBio2_001399
KBio2_003057
KBio2_003967
KBio2_005625
KBio2_006535
KBio3_000897
KBio3_000898
KBio3_001396
KBioGR_000395
KBioGR_000489
KBioSS_000489
KBioSS_001399
L000959
LS-187
LS-82147
Lausit
Liometacen
Lopac-I-7378
Lopac0_000692
MLS000069402
MLS000758212
MLS001074194
Metacen
Metartril
Methazine
Metindol
Mezolin
Miametan
Mikametan
Mobilan
MolMap_000032
MolPort-000-917-894
NCGC00015562-01
NCGC00015562-02
NCGC00015562-03
NCGC00015562-08
NCGC00015562-19
NCGC00024135-02
NCGC00024135-04
NCGC00024135-05
NCGC00024135-06
NCGC00024135-07
NCGC00024135-08
NCGC00024135-09
NCGC00024135-11
NCI-C56144
NCI60_041708
NINDS_000271
Novo-Methacin
Novomethacin
Oprea1_686105
Prestwick0_000272
Prestwick1_000272
Prestwick2_000272
Prestwick3_000272
Prestwick_597
Reumacide
Rhemacin LA
Rheumacin LA
S00108
S1723_Selleck
SMR000058195
SMR000449290
SPBio_000979
SPBio_002363
SPECTRUM1500350
Sadoreum
Spectrum2_000970
Spectrum3_000468
Spectrum4_000018
Spectrum5_000868
Spectrum_000919
Tannex
Tocris-1708
UNII-XXE1CET956
UPCMLD-DP023
UPCMLD-DP023:001
USAN
Vonum
indometacin
indomethacin
nchembio.147-comp11
{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid
10
IbuprofenapprovedPhase 4, Phase 3, Phase 2, Phase 151815687-27-13672
Synonyms:
(4-isobutylphenyl)-α-methylacetic acid
(RS)-ibuprofen
(±)-2-(p-isobutylphenyl)propionic acid
(±)-ibuprofen
(±)-p-isobutylhydratropic acid
(±)-α-methyl-4-(2-methylpropyl)benzeneacetic acid
139466-08-3
15687-27-1
2-(4-isobutylphenyl)propanoic acid
4-isobutylhydratropic acid
58560-75-1
AC-11312
AC1L1GGE
AC1Q1P84
AC1Q1P85
ACHES-N-PAIN
ARONIS23835
Act-3
Actiprofen
Adex 200
Adran
Advil
Advil (TN)
Advil Liqui-Gels
Ak+C2278tren
Alaxan
Algofen
Am-Fam 400
Amelior
Amersol
Amibufen
Anafen
Anco
Andran
Anflagen
Antagil
Antalfene
Antarene
Antiflam
Apo-Ibuprofen
Apsifen
Apsifen-F
Artofen
Artril
Artril 300
BB_SC-1358
BIDD:GT0050
BRN 2049713
Balkaprofen
Betaprofen
Bloom
Bluton
Brofen
Brufanic
Brufen
Brufen 400
Bruflam
Brufort
Buburone
Bufeno
Bufigen
Bukrefen
Bupron
Buracaps
Burana
Butylenin
C01588
C13H18O2
CCRIS 3223
CHEBI:5855
CHEMBL521
CID3672
CPD000058184
Cap-Profen
Carol
Cesra
Children's Advil
Children's Elixsure
Children's Ibuprofen
Children's Motrin
Citalgan
Cobo
Codral
Combiflam
Cunil
D00126
D007052
DB01050
DOLO PUREN
Daiprophen
Dalsy
Dansida
Deep Relief
Dentigoa
Dibufen
Dignoflex
Dolgin
Dolgirid
Dolgit
Dolibu
Dolmaral
Dolo-Dolgit
Dolocyl
Dolofen
Dolofen-F
Dolofin
Dolofort
Dologel
Dolomax
Doloren
Dolormin
Doltibil
Dolven
Donjust B
Dorival
Drin
Duafen
Duobrus
Dura-Ibu
Duralbuprofen
Dysdolen
EU-0100691
Easifon
Ebufac
Emflam
Emflam-200
Emodin
Epobron
Eputex
Ergix
Esprenit
Exneural
Faspic
Femadon
Femafen
Femapirin
Femidol
Fenbid
Fenbid Spansule
Fendol
Fenspan
Fibraflex
Gelufene
Gofen
Grefen
Gynofug
HMS1920F15
HMS2089P05
HMS2091N03
HMS502M09
HSDB 3099
Haltran
I 4883
I01-7039
I0415
I4883_SIGMA
I7905_SIAL
IB-100
IDI1_000887
IP 82
IP-82
IP82
Ibol
Ibren
Ibu
Ibu-Attritin
Ibu-Slo
Ibu-Tab
Ibu-Tab 200
Ibu-slo
Ibu-slow
Ibubest
Ibubeta
Ibucasen
Ibudol
Ibudolor
 
Ibufen
Ibuflamar
Ibufug
Ibugel
Ibugen
Ibugesic
Ibuhexal
Ibulagic
Ibular
Ibulav
Ibuleve
Ibulgan
Ibumed
Ibumerck
Ibumetin
Ibupirac
Ibuprin
Ibuprocin
Ibuprofene
Ibuprofeno
Ibuprofenum
Ibuprohm
Ibuprophen
Ibusal
Ibutid
Ifen
Inabrin
Inflam
Inoven
Ipren
Irfen
Isodol
Jenaprofen
Junifen
Junior Strength Advil
Junior Strength Ibuprofen
Junior Strength Motrin
KBio1_000887
KBio2_001329
KBio2_003897
KBio2_006465
KBio3_001390
Kesan
Kratalgin
LS-7454
Lamidon
Lebrufen
Librofem
Lidifen
Liptan
Lopane
MLS000069733
MLS001146965
Malafene
Manypren
Medipren
Melfen
Mensoton
Midol
Midol 200
Moment
Motrin
Motrin (TN)
Motrin IB
Mynosedin
NCI60_002065
NINDS_000887
NSC 256857
NSC256857
Nagifen-D
Napacetin
Narfen
Neo-Helvagit
Neo-Mindol
NeoProfen
Neobrufen
Nerofen
Noalgil
Nobafon
Nobfelon
Nobfen
Nobgen
Noritis
Norton
Novadol
Novo-Profen
Novogent
Novogent N
Novoprofen
Nuprilan
Nuprin
Nurofen
Optifen
Opturem
Oralfene
Ostarin
Ostofen
Ozonol
P-Isobutylhydratropic Acid
Paduden
Panafen
Pantrop
Para-Isobutylhydratropic Acid
Paxofen
Pedia-Profen
PediaProfen
Pediaprofen
Pediatric Advil
Perofen
Proartinal
Profen
Proflex
Provon
Quadrax
R.D. 13621
RD 13621
Rafen
Ranofen
Rebugen
Relcofen
Rhinadvil
Rofen
Roidenin
Rufen
Rufin
Rupan
SAM002264619
SMR000058184
SPBio_000178
STK177358
Sadefen
Salivia
Salprofen
Seclodin
Sednafen
Seklodin
Seskafen
Siyafen
Solpaflex
Solufen
Stelar
Sugafen
Suprafen
Suspren
Syntofene
TL8001184
Tab-Profen
Tabalon
Tabalon 400
Tatanal
Tempil
Tofen
Togal N
Tonal
Trendar
U 18573
U-18,573
U-18573
UCB 79171
Unipron
Upfen
Uprofen
Urem
VUFB 9649
Zafen
Zofen
alpha-(4-Isobutylphenyl)propionate
alpha-(4-Isobutylphenyl)propionic acid
alpha-p-Isobutylphenylpropionate
alpha-p-Isobutylphenylpropionic acid
ibuprofen
p-Isobutyl-2-phenylpropionate
p-Isobutyl-2-phenylpropionic acid
p-Isobutylhydratropate
p-Isobutylhydratropic acid
α-(4-isobutylphenyl)propionic acid
α-(p-isobutylphenyl)propionic acid
11
Vitamin Aapproved, nutraceutical, vet_approvedPhase 4, Phase 349211103-57-4, 68-26-8445354
Synonyms:
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
.alpha.lin
.alpha.sterol
.beta.-Retinol
11103-57-4
13123-33-6
1341-18-0
1406-67-3
17104-91-5
1rbp
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclchexen-1-yl)-2,4,6,8-nonatetraen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonate-traen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraen-1-ol
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer
4-06-00-04133 (Beilstein Handbook Reference)
53637-36-8
5979-23-7
68-26-8
95144_FLUKA
95144_SIGMA
95146_FLUKA
95146_SIGMA
A-Mulsal
A-Sol
A-Vi-Pel
A-Vitan
AC-11701
AC1L9HU3
AC1Q7BU9
ACON
ALL-TRANS RETINOL (SEE ALSO RETINOID PROJECT 1)
AR-1L3057
ATAV
Afaxin
Agiolan
Agoncal
Alcohol 9,13-dimethyl-7-(1,1,5-trimethyl-6-cyclohexen-5-yl)-7,9,11,13-nonatetraen-15-ol
Alcovit A
All Trans Retinol
All-trans retinol
All-trans-Retinol
Alphalin
Alphasterol
Anatola
Anatola A
Anti-infective vitamin
Antixerophthalmic vitamin
Antixerophthalmisches Vitamin
Aoral
Apexol
Apostavit
Aquasol A Parenteral
Aquasynth
Atars
Avibon
Avita
Avitol
Axerol
Axerophthol
Axerophtholum
BIDD:PXR0102
BRN 0403040
Bentavit A
Biosterol
C00473
C17276
C20H30O
CCRIS 5444
CHEBI:17336
CHEMBL986
CID445354
Chocola A
Cylasphere
D014801
D06543
DB00162
Del-VI-A
Disatabs Tabs
Dofsol
Dohyfral A
EINECS 200-683-7
EINECS 234-328-2
Epiteliol
HMS1921B04
HMS2092L13
HMS501I08
HSDB 815
Hi-A-Vita
Homagenets Aoral
Homagenets aorl
Hydrovit A
IDI1_000486
LMPR01090001
LPK
LS-1578
Lard Factor
M.V.C. 9+3
M.V.I.-12
 
MLS001066379
MLS001074751
MolPort-001-785-962
Mvc Plus
Myvpack
NCGC00091784-01
NCGC00091784-02
NCGC00091784-03
NCGC00091784-04
NCGC00091784-05
NCGC00091784-06
NSC 122759
NSC122759
Nio-A-Let
Oleovitamin A
Ophthalamin
Plivit A
Prepalin
R7632_SIGMA
Retin-11,12-t2-ol (9CI)
Retinol
Retinol [INN:BAN]
Retinol solution
Retinol, all-trans- (8CI)
Retinol-(cellular-retinol-binding-protein)
Retinolo
Retinolo [DCIT]
Retinolum
Retinolum [INN-Latin]
Retrovitamin A
Ro-a-vit
Rovimix A 500
SDCCGMLS-0066724.P001
SMP2_000102
SMR000112036
SPECTRUM1501203
ST057232
Sehkraft A
Solu-A
Spectrum5_000993
Spectrum5_001997
Super A
Testavol
Testavol S
Thalasphere
UNII-81G40H8B0T
UNII-G2SH0XKK91
Vaflol
Vafol
Veroftal
Vi-.alpha.
Vi-Alpha
Vi-Dom-A
Vi-a
Vio-A
Vitamin A
Vitamin A (Feed)
Vitamin A (USP)
Vitamin A alcohol
Vitamin A alcohol (VAN)
Vitamin A cryst
Vitamin A1
Vitamin A1 alcohol
Vitamin A1 alcohol, all trans
Vitamin- A
Vitamin- A alcohol
Vitamin- A alcohol solution
Vitamin- A1
Vitamin-?A
Vitamin-?A alcohol
Vitamin-?A alcohol solution
Vitamin-?A1
Vitamine A
Vitaminum A
Vitavel A
Vitavel-A
Vitpex
Vogan
Vogan-Neu
Vogan-nu
WLN: L6UTJ A1 B1U1Y1&U2U1Y1&U2Q C1 C1
Wachstumsvitamin
ZINC03831417
Zinosan N
[11,12-3H]-Retinol
alin
all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
all-trans-Retinol
all-trans-Retinyl alcohol
all-trans-Vitamin A
all-trans-Vitamin A alcohol
all-trans-Vitamin A1
all-trans-retinol
all-trans-retinyl alcohol
all-trans-vitamin A alcohol
b-Retinol
beta-Retinol
retinol
tROL
trans-Retinol
trans-Retinol acid (Vitamin A)
trans-Vitamin A alcohol
trans-retinol
12
Caffeineapproved, NutraceuticalPhase 4, Phase 3, Phase 239658-08-22519
Synonyms:
07E4FB58-FD79-4175-8E3D-05BF96954522
1,3,7-Trimethyl-2,6-dioxopurine
1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione
1,3,7-Trimethylpurine-2,6-dione
1,3,7-Trimethylxanthine
1,3,7-trimethyl-2,6-dioxopurine
1,3,7-trimethylpurine-2,6-dione
1,3,7-trimethylxanthine
1-3-7-TRIMETHYLXANTHINE
1-Methyl-Theobromine
1-methyltheobromine
137X
1gfz
1l5q
1l7x
27602_FLUKA
2a3b
3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
3,7-dihydro-1,3,7-trimethyl-1H-purine
5-26-13-00558 (Beilstein)
58-08-2
7-Methyl Theophylline
7-Methyltheophylline
7-methyltheophylline
71701-02-5
75035_FLUKA
95789-13-2
A.S.A. and Codeine Compound
AC-12774
AC1L1DV2
AC1Q3Z23
ACon1_000085
AI3-20154
AKOS000121334
Alert-Pep
Alert-pep
Anacin Maximum Strength
Anhydrous caffeine
Anhydrous caffeine (JP15)
Anhydrous caffeine (TN)
Anoquan
BIDD:ER0554
BIDD:GT0632
BIDD:PXR0172
BIM-0050216.0001
BRD-K02404261-001-02-7
BRD-K02404261-001-03-5
BRN 0017705
BSPBio_001921
Berlin-Chemie Brand of Caffeine
Bio-0579
Bio1_000473
Bio1_000962
Bio1_001451
Bristol-Myers Squibb Brand of Caffeine
C 0750
C07481
C0750_SIAL
C1778_SIAL
C2042
C6035_FLUKA
C6035_SIGMA
C7731_SIAL
C8960_SIAL
CCRIS 1314
CFF
CHEBI:27732
CHEMBL113
CID2519
CU-01000012617-3
Cafamil
Cafcit
Cafecon
Cafeina
Cafergot
Cafeína
Caffedrine
Caffedrine Caplets
Caffein
Caffeina
Caffeina [Italian]
Caffeine (USP)
Caffeine (natural)
Caffeine Pure
Caffeine [BAN:JAN]
Caffeine solution
Caffeine, Anhydrous
Caffeine, Monohydrate
Caffeine, Synthetic
Caffeine, anhydrous
Caffeine, synthetic
Caffeinum
Caffine
Cafipel
Caféine
Coffein
Coffein [German]
Coffeine
Coffeinum
Coffeinum N
Coffeinum Purrum
Compound 65
D002110
D00528
DB00201
DHC Plus
DHCplus
Darvon Compound
Darvon Compound-65
Dasin
Dexitac
Dexitac Stay Alert Stimulant
Dhc Plus
Diurex
DivK1c_000730
Durvitan
EINECS 200-362-1
EU-0100228
Eldiatric C
Enerjets
Ercatab
Esgic
Esgic-Plus
FEMA No. 2224
Femcet
Fioricet
Fiorinal
GlaxoSmithKline Brand of Caffeine
Guaranine
HMS1920I09
HMS2091O11
HMS502E12
HSDB 36
Hycomine
Hycomine Compound
I14-4386
 
IDI1_000730
Invagesic
Invagesic Forte
KBio1_000730
KBio2_001781
KBio2_004349
KBio2_006917
KBio3_001141
KBioGR_002325
KBioSS_001781
Keep Alert
Kofein
Kofein [Czech]
Koffein
Koffein [German]
L000155
LS-237
Lanorinal
Lopac-C-0750
Lopac0_000228
MEGxp0_001350
MLS001055341
MLS001056714
MLS001066409
Mateina
Mateína
Maximum Strength Snapback Stimulant Powders
Medigesic Plus
Merck dura Brand of Caffeine
Methyltheobromide
Methyltheobromine
Methylxanthine theophylline
Midol Maximum Strength
Migergot
Miudol
MolMap_000054
MolPort-000-730-850
Monohydrate Caffeine
Monomethyl Derivative of Theophylline
Monomethyl derivative of Theophylline
NCGC00015208-01
NCGC00015208-02
NCGC00015208-04
NCGC00015208-14
NCGC00090699-01
NCGC00090699-02
NCGC00090699-03
NCGC00090699-04
NCGC00090699-05
NCGC00090699-06
NCGC00090699-07
NCGC00090699-08
NCGC00090699-09
NCGC00168808-01
NCGC00168808-02
NCI-C02733
NCIOpen2_008255
NINDS_000730
NSC 5036
NSC5036
Natural Caffeinum
Nix Nap
No Doz
No-Doz
Nodaca
Nodoz Maximum Strength Caplets
Norgesic
Norgesic Forte
Organex
Orphengesic
Orphengesic Forte
P-A-C Analgesic Tablets
PDSP1_001016
PDSP1_001235
PDSP2_001000
PDSP2_001219
Passauer Brand of Caffeine
Pep-Back
Percoffedrinol N
Percutafeine
Phensal
Pierre Fabre Brand of Caffeine
Probes1_000150
Probes2_000128
Propoxyphene
Propoxyphene Compound 65
Propoxyphene Compound-65
Quick Pep
Quick-Pep
Refresh'n
Republic Drug Brand of Caffeine
SDCCGMLS-0064595.P001
SDCCGMLS-0064595.P002
SK 65 Compound
SK-65 Compound
SMR000326667
SPBio_001222
SPECTRUM1500155
STK177283
Seid Brand of Caffeine
Spectrum2_001261
Spectrum3_000321
Spectrum4_001782
Spectrum5_000423
Spectrum_001301
Stim
Synalgos-Dc
TNP00310
Thein
Theine
Theobromine ME
Theobromine Me
Theophylline ME
Theophylline Me
Theophylline, 7-methyl
Thompson Brand 1 of Caffeine
Thompson Brand 2 of Caffeine
Tirend
Tri-Aqua
Triad
UNII-3G6A5W338E
Ultra Pep-Back
Vivarin
W222402_ALDRICH
WLN: T56 BN DN FNVNVJ B1 F1 H1
Wake-Up
Wigraine
Xanthine, 1,3,7-trimethyl
ZINC00001084
bmse000206
cafeine
caffeine
caffenium
component of Cafergot
nchembio.243-comp7
nchembio.63-comp5
nchembio774-comp2
teina
teína
13Angiogenesis Modulating AgentsPhase 4, Phase 2, Phase 3, Phase 14185
14Respiratory System AgentsPhase 4, Phase 2, Phase 3, Phase 14997
15AnalgesicsPhase 4, Phase 3, Phase 2, Phase 111733
16AntioxidantsPhase 4, Phase 3, Phase 2, Phase 13050
17MicronutrientsPhase 4, Phase 3, Phase 26001
18Trace ElementsPhase 4, Phase 3, Phase 26001
19Retinol palmitatePhase 4, Phase 3492
20Protective AgentsPhase 4, Phase 3, Phase 2, Phase 17443
21VitaminsPhase 4, Phase 3, Phase 25282
22Angiogenesis InhibitorsPhase 4, Phase 2, Phase 3, Phase 14257
23Cyclooxygenase InhibitorsPhase 4, Phase 3, Phase 2, Phase 12870
24Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 2, Phase 123689
25Pulmonary SurfactantsPhase 4, Phase 3, Phase 2111
26Antirheumatic AgentsPhase 4, Phase 3, Phase 2, Phase 110956
27Anti-Inflammatory Agents, Non-SteroidalPhase 4, Phase 3, Phase 2, Phase 14443
28Analgesics, Non-NarcoticPhase 4, Phase 3, Phase 2, Phase 16501
29Anti-Inflammatory AgentsPhase 4, Phase 3, Phase 2, Phase 110729
30AnestheticsPhase 4, Phase 2, Phase 39596
31Ketorolac TromethaminePhase 4, Phase 2323
32Central Nervous System DepressantsPhase 4, Phase 313403
33Excitatory Amino AcidsPhase 41362
34Excitatory Amino Acid AntagonistsPhase 41347
35Purinergic P1 Receptor AntagonistsPhase 4, Phase 3, Phase 2360
36Phosphodiesterase InhibitorsPhase 4, Phase 3, Phase 21289
37MitogensPhase 4, Phase 1, Phase 21617
38Endothelial Growth FactorsPhase 4, Phase 1, Phase 2382
39Platelet Aggregation InhibitorsPhase 4, Phase 32516
40Neurotransmitter AgentsPhase 4, Phase 2, Phase 3, Phase 118340
41Neuromuscular Blocking AgentsPhase 4429
42Hypnotics and SedativesPhase 42616
43Chelating AgentsPhase 4, Phase 21423
44Tocolytic AgentsPhase 4, Phase 3739
45Anti-Infective AgentsPhase 4, Phase 3, Phase 1, Phase 222062
46LactoferrinPhase 451
47Anesthetics, GeneralPhase 4, Phase 32934
48Anesthetics, InhalationPhase 4, Phase 3684
49Anesthetics, IntravenousPhase 42538
50AnticoagulantsPhase 4, Phase 22623

Interventional clinical trials:

(show top 50)    (show all 193)
idNameStatusNCT IDPhase
1Efficient Study of ACULAR in Inhibiting Proliferative Retinopathy in PrematurityUnknown statusNCT00634972Phase 4
2Withholding Feeds During Red Blood Cell Transfusion and TRAGIUnknown statusNCT02132819Phase 4
3Cpap at Delivery Room for Preterm InfantsUnknown statusNCT01024361Phase 4
4Early CPAP in Respiratory Distress SyndromeUnknown statusNCT00368680Phase 4
5Sucrose Analgesia for the Reduction of Pain During Retinopathy of Prematurity ScreeningCompletedNCT00921544Phase 4
6Anesthesia for Retinopathy of PrematurityCompletedNCT01955135Phase 4
7Vascular Endothelial Growth Factor in Stage V ROPCompletedNCT00500396Phase 4
8VEGF Levels in Aqueous, Vitreous and Subretinal Fluid in ROP Stage IV and VCompletedNCT00563121Phase 4
9Vitamin A and Very Low Birthweight Babies (VitAL)CompletedNCT00417404Phase 4
10Early Versus Late Lactoferrin in Prevention of Neonatal SepsisCompletedNCT02959229Phase 4
11MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose CaffeineCompletedNCT00809055Phase 4
12Safety and Tolerability of Ranibizumab in Patients With Subfoveal Choroidal Neovascularization Secondary to Age-related Macular DegenerationCompletedNCT00504959Phase 4
13OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAPRecruitingNCT02140580Phase 4
14VEGF Concentrations After Intravitreal Bevacizumab vs Ranibizumab as a Treatment for Type 1 ROPNot yet recruitingNCT03148132Phase 4
15Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature BabiesWithdrawnNCT00470743Phase 4
16Antiangiogenic Therapy With Bevacizumab in Retinopathy of Prematurity. Structural OutcomeUnknown statusNCT00346814Phase 2, Phase 3
17The Early Treatment for Retinopathy of Prematurity Study (ETROP)Unknown statusNCT00027222Phase 2, Phase 3
18Oral Vitamin A Supplementation in Neonates With Birth Weight < 1500 gUnknown statusNCT02102711Phase 3
19Randomized Study of Pessary Versus Standard Management in Women With Increased Chance of Premature BirthUnknown statusNCT00735137Phase 3
20Cysteine Supplementation in Critically Ill NeonatesUnknown statusNCT00254176Phase 2, Phase 3
21A Fatty Acids Study in Preventing Retinopathy of PrematurityCompletedNCT02760472Phase 3
22Safety and Efficacy of Propranolol in Newborns With Retinopathy of PrematurityCompletedNCT01079715Phase 2, Phase 3
23The Effects of Light Reduction on Retinopathy of Prematurity (Light-ROP)CompletedNCT00000156Phase 3
24Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of PrematurityCompletedNCT01203436Phase 2, Phase 3
25Inhaled Nitrous Oxide for Pain Relief During Eye Exam in the Pre-term InfantCompletedNCT00623220Phase 3
26Premature Infants in Need of Transfusion (PINT)CompletedNCT00182390Phase 3
27Oxygen Toxicity in the Resuscitation in Extremely Premature InfantsCompletedNCT00494702Phase 3
28Inhaled Nitric Oxide to Prevent and Treat Bronchopulmonary DysplasiaCompletedNCT01503801Phase 2, Phase 3
2917OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet PregnanciesCompletedNCT00163020Phase 2, Phase 3
30Caffeine for Apnea of Prematurity (CAP)CompletedNCT00182312Phase 3
31Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)CompletedNCT00009646Phase 3
32NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome)CompletedNCT02259400Phase 2, Phase 3
33Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams BirthweightCompletedNCT00734539Phase 3
34Canadian Oxygen Trial (COT)CompletedNCT00637169Phase 3
35Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)CompletedNCT00433212Phase 3
36Omega-3 Fatty Acid Supplementation to Prevent Preterm Birth in High Risk PregnanciesCompletedNCT00135902Phase 3
37High Versus Low Dose of Caffeine for Apnea of PrematurityCompletedNCT02103777Phase 3
38Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth WeightCompletedNCT00114543Phase 3
39Pentoxifylline and Late Onset Sepsis in Preterm InfantsCompletedNCT02163174Phase 3
40Safety and Efficacy Study of Ibuprofen l-Lysine Solution in Premature Infants for Treatment of PDACompletedNCT00440804Phase 3
41High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia PreventionCompletedNCT01355159Phase 3
42Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS)CompletedNCT00099164Phase 3
43Prevention Trial of Nosocomial Infections in Neutropenic Prematures With G-CSFCompletedNCT00213759Phase 3
44RAINBOW Study: RAnibizumab Compared With Laser Therapy for the Treatment of INfants BOrn Prematurely With Retinopathy of PrematurityRecruitingNCT02375971Phase 3
45Rainbow Extension StudyRecruitingNCT02640664Phase 3
46Sildenafil Therapy In Dismal Prognosis Early-Onset Intrauterine Growth RestrictionRecruitingNCT02442492Phase 2, Phase 3
47Dose Reduction of Antenatal Betamethasone Given to Prevent the Neonatal Complications Associated With Very Preterm BirthRecruitingNCT02897076Phase 3
48A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV)RecruitingNCT01376778Phase 3
49Maternal Omega-3 Supplementation to Reduce Bronchopulmonary DysplasiaRecruitingNCT02371460Phase 3
50Comparison of Two Flow Rates of HHHFNC to Prevent Extubation Failure in Preterm InfantsRecruitingNCT02681315Phase 3

Search NIH Clinical Center for Exudative Vitreoretinopathy 1


Cochrane evidence based reviews: retinopathy of prematurity

Genetic Tests for Exudative Vitreoretinopathy 1

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Genetic tests related to Exudative Vitreoretinopathy 1:

id Genetic test Affiliating Genes
1 Exudative Vitreoretinopathy 127
2 Retinopathy of Prematurity27 24 FZD4
3 Familial Exudative Vitreoretinopathy, Autosomal Dominant27 24 FZD4, LRP5, TSPAN12

Anatomical Context for Exudative Vitreoretinopathy 1

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MalaCards organs/tissues related to Exudative Vitreoretinopathy 1:

36
Retina, Eye

Publications for Exudative Vitreoretinopathy 1

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Variations for Exudative Vitreoretinopathy 1

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UniProtKB/Swiss-Prot genetic disease variations for Exudative Vitreoretinopathy 1:

70 (show all 23)
id Symbol AA change Variation ID SNP ID
1FZD4p.Met105ValVAR_038947rs80358284
2FZD4p.Met157ValVAR_038948rs80358286
3FZD4p.Gly36AspVAR_063921rs80358281
4FZD4p.Glu40GlnVAR_063922rs139401671
5FZD4p.His69TyrVAR_063923rs80358282
6FZD4p.Met105ThrVAR_063924rs80358285
7FZD4p.Ile114ThrVAR_063925
8FZD4p.Cys181ArgVAR_063927rs80358287
9FZD4p.Cys204ArgVAR_063929rs80358288
10FZD4p.Cys204TyrVAR_063930
11FZD4p.Met223LysVAR_063931
12FZD4p.Ile256ValVAR_063932rs104894223
13FZD4p.Trp335CysVAR_063933rs80358292
14FZD4p.Met342ValVAR_063934rs80358293
15FZD4p.Arg417GlnVAR_063936rs80358294
16FZD4p.Thr445ProVAR_063937rs80358297
17FZD4p.Gly488AspVAR_063938rs80358298
18FZD4p.Ser497PheVAR_063939rs80358300
19FZD4p.Gly525ArgVAR_063940
20LRP5p.Arg348TrpVAR_063948
21LRP5p.Asp381AsnVAR_076548
22LRP5p.Arg624TrpVAR_076549
23LRP5p.Tyr1517CysVAR_076550rs201030241

Clinvar genetic disease variations for Exudative Vitreoretinopathy 1:

5
id Gene Variation Type Significance SNP ID Assembly Location
1CTNNB1NM_ 001904.3(CTNNB1): c.1434_ 1435insC (p.Glu479Argfs)insertionPathogenicrs1057519379GRCh38Chr 3, 41233777: 41233778
2CTNNB1NM_ 001904.3(CTNNB1): c.2128C> T (p.Arg710Cys)SNVPathogenicrs748653573GRCh37Chr 3, 41279558: 41279558
3CTNNB1NM_ 001904.3(CTNNB1): c.2142_ 2157dup16 (p.His720Terfs)duplicationPathogenicrs1057519380GRCh37Chr 3, 41280629: 41280644
4FZD4NM_ 012193.3(FZD4): c.1479_ 1484delGTGGAT (p.Met493_ Trp494del)deletionPathogenicrs80358301GRCh37Chr 11, 86662314: 86662319
5FZD4NM_ 012193.3(FZD4): c.1501_ 1502delCT (p.Leu501Serfs)deletionPathogenicrs80358303GRCh37Chr 11, 86662296: 86662297
6FZD4NM_ 012193.3(FZD4): c.1250G> A (p.Arg417Gln)SNVPathogenicrs80358294GRCh37Chr 11, 86662548: 86662548
7FZD4NM_ 012193.3(FZD4): c.1024A> G (p.Met342Val)SNVPathogenicrs80358293GRCh37Chr 11, 86662774: 86662774
8FZD4NM_ 012193.3(FZD4): c.1005G> C (p.Trp335Cys)SNVPathogenicrs80358292GRCh37Chr 11, 86662793: 86662793
9FZD4NM_ 012193.3(FZD4): c.766A> G (p.Ile256Val)SNVPathogenicrs104894223GRCh37Chr 11, 86663032: 86663032

Expression for genes affiliated with Exudative Vitreoretinopathy 1

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Search GEO for disease gene expression data for Exudative Vitreoretinopathy 1.

Pathways for genes affiliated with Exudative Vitreoretinopathy 1

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Pathways related to Exudative Vitreoretinopathy 1 according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathwaysScoreTop Affiliating Genes
110.0CDKN1C, CTNNB1, LRP5
210.0EPO, IGF1, VEGFA
310.0CTNNB1, LRP5, TEK
4
Show member pathways
9.9FLT1, KDR, VEGFA
59.9ANGPT2, EPO, VEGFA
69.9CTNNB1, FZD4, LRP5, VEGFA
79.9FLT1, TEK, VEGFA
89.8CTNNB1, FLT1, KDR, VEGFA
9
Show member pathways
9.7CTNNB1, KDR, NRP1, VEGFA
109.7EPO, FLT1, KDR, VEGFA
119.7CDKN1C, IGF1, SERPINH1, VEGFA
129.7CTNNB1, FZD4, IGF1, KDR, VEGFA
13
Show member pathways
9.7FLT1, KDR, TEK, VEGFA
14
Show member pathways
9.7FLT1, KDR, NRP1, VEGFA
15
Show member pathways
9.7FLT1, KDR, NRP1, VEGFA
16
Show member pathways
9.6FLT1, FZD4, IGF1, KDR, LRP5
179.6ANGPT2, FLT1, KDR, TEK
18
Show member pathways
9.6ANGPT2, FLT1, KDR, TEK
19
Show member pathways
9.5CTNNB1, FLT1, KDR, NRP1, VEGFA
20
Show member pathways
9.3CTNNB1, FLT1, FZD4, IGF1, KDR, LRP5
219.3ANGPT2, EPO, FLT1, IGF1, TEK, VEGFA
22
Show member pathways
9.2CTNNB1, FLT1, FZD4, IGF1, KDR, TEK
23
Show member pathways
9.2ANGPT2, CTNNB1, FLT1, IGF1, KDR, TEK
249.1ANGPT2, EPO, FLT1, IGF1, KDR, TEK
25
Show member pathways
9.1ANGPT2, CTNNB1, FLT1, IGF1, KDR, NRP1
26
Show member pathways
8.6ANGPT2, CTNNB1, FLT1, FZD4, IGF1, KDR

GO Terms for genes affiliated with Exudative Vitreoretinopathy 1

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Cellular components related to Exudative Vitreoretinopathy 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sorting endosomeGO:009744310.3KDR, NRP1
2Wnt signalosomeGO:199090910.2CTNNB1, LRP5
3cell surfaceGO:000998610.0CD38, EPO, FZD4, NDP, NRP1, TEK
4extracellular spaceGO:00056159.2ANGPT2, EPO, FLT1, IGF1, NDP, NRP1
5extracellular regionGO:00055769.1ANGPT2, DEFB127, EPO, FLT1, IGF1, KDR

Biological processes related to Exudative Vitreoretinopathy 1 according to GeneCards Suite gene sharing:

(show all 49)
idNameGO IDScoreTop Affiliating Genes
1retinal blood vessel morphogenesisGO:006130411.0FZD4, LRP5
2positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayGO:003803310.9KDR, VEGFA
3negative regulation of cell-substrate adhesionGO:001081210.9ANGPT2, FZD4
4positive regulation of positive chemotaxisGO:005092710.9KDR, VEGFA
5positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.9EPO, IGF1
6commissural neuron axon guidanceGO:007167910.9NRP1, VEGFA
7coronary artery morphogenesisGO:006098210.9NRP1, VEGFA
8endothelial cell chemotaxisGO:003576710.9NRP1, VEGFA
9motor neuron migrationGO:009747510.9NRP1, VEGFA
10positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:003094910.9FLT1, VEGFA
11extracellular matrix-cell signalingGO:003542610.9FZD4, LRP5, NDP
12positive regulation of axon extension involved in axon guidanceGO:004884210.9NRP1, VEGFA
13positive regulation of retinal ganglion cell axon guidanceGO:190233610.8NRP1, VEGFA
14regulation of retinal ganglion cell axon guidanceGO:009025910.8NRP1, VEGFA
15glomerulus vasculature developmentGO:007201210.8ANGPT2, TEK
16positive regulation of mesenchymal cell proliferationGO:000205310.8CTNNB1, LRP5, VEGFA
17kidney developmentGO:000182210.8CDKN1C, CTNNB1, VEGFA
18branching involved in blood vessel morphogenesisGO:000156910.7CTNNB1, NRP1, VEGFA
19canonical Wnt signaling pathwayGO:006007010.7CTNNB1, FZD4, LRP5, NDP
20positive regulation of tyrosine phosphorylation of STAT proteinGO:004253110.7EPO, IGF1, VEGFA
21sympathetic ganglion developmentGO:006154910.7CTNNB1, NRP1
22cell migration involved in sprouting angiogenesisGO:000204210.7KDR, NRP1, VEGFA
23positive regulation of sequence-specific DNA binding transcription factor activityGO:005109110.7CTNNB1, FZD4, LRP5, NDP
24positive regulation of focal adhesion assemblyGO:005189410.7KDR, TEK, VEGFA
25negative regulation of angiogenesisGO:001652510.7ANGPT2, CTNNB1, TEK
26positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.7IGF1, NRP1, VEGFA
27VEGF-activated neuropilin signaling pathwayGO:003819010.7NRP1, VEGFA
28Tie signaling pathwayGO:004801410.6ANGPT2, TEK
29retina vasculature morphogenesis in camera-type eyeGO:006129910.6FZD4, LRP5, NDP, NRP1
30positive regulation of MAPK cascadeGO:004341010.5CTNNB1, FLT1, IGF1, KDR
31positive regulation of cell migrationGO:003033510.5FLT1, IGF1, KDR, VEGFA
32cellular response to vascular endothelial growth factor stimulusGO:003592410.5FLT1, KDR, NRP1, VEGFA
33vasculogenesisGO:000157010.5CTNNB1, FZD4, KDR, VEGFA
34vascular endothelial growth factor signaling pathwayGO:003808410.4FLT1, KDR, NRP1
35positive regulation of phosphatidylinositol 3-kinase signalingGO:001406810.4FLT1, IGF1, KDR, TEK
36positive regulation of endothelial cell migrationGO:001059510.4KDR, NRP1, TEK, VEGFA
37positive regulation of endothelial cell proliferationGO:000193810.4KDR, NRP1, TEK, VEGFA
38positive regulation of ERK1 and ERK2 cascadeGO:007037410.4EPO, KDR, NRP1, TEK
39vascular endothelial growth factor receptor signaling pathwayGO:004801010.3FLT1, KDR, NRP1, VEGFA
40response to hypoxiaGO:000166610.3ANGPT2, CD38, EPO, TEK, VEGFA
41positive regulation of angiogenesisGO:004576610.3ANGPT2, FLT1, KDR, TEK, VEGFA
42negative regulation of apoptotic processGO:004306610.2CD38, EPO, IGF1, KDR, TEK, VEGFA
43cell differentiationGO:003015410.1ANGPT2, CTNNB1, FLT1, KDR, NRP1, VEGFA
44positive regulation of cell proliferationGO:000828410.1CTNNB1, EPO, FLT1, IGF1, KDR, LRP5
45multicellular organism developmentGO:000727510.0ANGPT2, FLT1, FZD4, KDR, LRP5, NRP1
46positive regulation of transcription, DNA-templatedGO:004589310.0CD38, CDKN1C, CTNNB1, EPO, FZD4, IGF1
47Wnt signaling pathwayGO:00160559.9CTNNB1, FZD4, LRP5, NDP
48angiogenesisGO:00015259.9ANGPT2, FLT1, KDR, NRP1, TEK, TSPAN12
49signal transductionGO:00071659.4ANGPT2, CD38, CTNNB1, EPO, FZD4, IGF1

Molecular functions related to Exudative Vitreoretinopathy 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor bindingGO:001983810.4FLT1, KDR, NRP1, TEK
2transmembrane receptor protein tyrosine kinase activityGO:000471410.2FLT1, KDR, TEK
3vascular endothelial growth factor-activated receptor activityGO:000502110.1FLT1, KDR, NRP1
4Wnt-activated receptor activityGO:004281310.1FZD4, LRP5, TSPAN12
5protein bindingGO:00055157.7ANGPT2, ATP7B, CDKN1C, CTNNB1, DEFB127, EPO

Sources for Exudative Vitreoretinopathy 1

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet