MCID: EYD002
MIFTS: 50

Eye Disease malady

Summaries for Eye Disease

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Some eye problems are minor and don't last long. but some can lead to a permanent loss of vision. common eye problems include refractive errors cataracts - clouded lenses glaucoma - a disorder caused by damage to the optic nerve retinal disorders - problems with the nerve layer at the back of the eye macular degeneration - a disease that destroys sharp, central vision diabetic eye problems conjunctivitis - an infection also known as pinkeye your best defense is to have regular checkups, because eye diseases do not always have symptoms. early detection and treatment could prevent vision loss. see an eye care professional right away if you have a sudden change in vision, if everything looks dim, or if you see flashes of light. other symptoms that need quick attention are pain, double vision, fluid coming from the eye, and inflammation. nih: national eye institute

MalaCards: Eye Disease, also known as eye infections, is related to fish-eye disease and blindness. An important gene associated with Eye Disease is CACNA1F (calcium channel, voltage-dependent, L type, alpha 1F subunit), and among its related pathways are Statin Pathway, Pharmacodynamics and Lipoprotein metabolism. The drugs prednisone and prednisone pwdr and the compounds triacylglycerol and p-opc have been mentioned in the context of this disorder. Related mouse phenotypes are pigmentation and vision/eye.

Wikipedia:64 This is a partial list of human eye diseases and disorders. more...

Aliases & Classifications for Eye Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 40NCIt, 57SNOMED-CT, 27ICD9CM, 35MeSH
See all sources

Aliases & Descriptions:

eye disease 8 10
eye infections 34 61
eye diseases 45 34
disorder of eye 61
eye infection 8


Related Diseases for Eye Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Eye Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1fish-eye disease30.7APOA1, APOA2, LCAT
2blindness30.6NDP, RS1, OAT
3aland island eye disease30.5OA2, NYX, ZNF41, CACNA1F, GK
4hyperopia30.2CACNA1F
5astigmatism30.2CACNA1F
6norum disease29.9APOA2, LCAT, APOA1
7hypoalphalipoproteinemia29.9APOA1, LCAT, APOA2
8tangier disease29.9APOA1, LCAT, APOA2
9congenital stationary night blindness29.9CACNA1F, NYX
10age related macular degeneration29.7RS1
11lip disease10.5
12corneal disease10.4
13strabismus10.3
14stromal keratitis10.2
15herpes simplex virus keratitis10.2
16graves' disease10.1
17vascular disease10.1
18vitreous disease10.1
19somatostatin analog10.1
20amblyopia10.1
21x-linked cone dysfunction syndrome with myopia10.1
22retinal degeneration10.0RS1, ROM1, NPHP1, RDH8, OAT
23retinal disease10.0NYX, ROM1, RS1, NDP, CACNA1F
24complete lcat deficiency10.0LCAT, APOA1, APOA2
25hyperalphalipoproteinemia10.0APOA2, APOA1, LCAT
26myopia 610.0NYX, RDH8, CACNA1F
27hypertriglyceridemia10.0APOA2, APOA1, GK, LCAT
28night blindness10.0NYX, CACNA1F
29rhyns syndrome10.0NPHP1, ROM1, RS1
30metabolic syndrome x10.0GK, APOA1, OAT, LCAT
31familial combined hyperlipidemia10.0APOA1, LCAT, APOA2
32abetalipoproteinemia10.0APOA1, LCAT
33x-linked congenital stationary night blindness10.0NYX, CACNA1F
34night blindness, congenital stationary , 2a, x-linked10.0CACNA1F, OA2
35cone-rod dystrophy x-linked 310.0OA2, CACNA1F
36arcus senilis10.0APOA1, LCAT
37alagille syndrome10.0APOA1, LCAT
38fundus dystrophy10.0ROM1, NPHP1, RDH8
39oguchi disease 110.0CACNA1F, NYX
40amyloidosis, renal10.0APOA2, APOA1
41familial hyperlipidemia10.0LCAT, APOA1, APOA2
42hereditary night blindness10.0CACNA1F, NYX
43amyloidosis, secondary10.0LCAT, APOA1
44gyrate atrophy10.0OAT
45familial hypertriglyceridemia10.0APOA1, APOA2
46intellectual disability10.0ZNF41, NDP, GK
47cerebroretinal microangiopathy with calcifications and cysts10.0NDP
48norrie disease10.0NDP
49hyperinsulinism10.0LCAT, APOA2, APOA1
50fundus albipunctatus10.0CACNA1F

Graphical network of the top 20 diseases related to Eye Disease:



Diseases related to eye disease

Clinical Features for Eye Disease

Drugs & Therapeutics for Eye Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Eye Disease

Drug clinical trials:

Search ClinicalTrials for Eye Disease

Search NIH Clinical Center for Eye Disease

Search CenterWatch for Eye Disease

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Eye Disease

Anatomical Context for Eye Disease

Animal Models for Eye Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Eye Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.6OAT, RS1, RDH8, NDP
2MP:000539110.6OAT, LCAT, CACNA1F, NDP, NPHP1, RDH8

Publications for Eye Disease

Sources:
51PubMed
See all sources

Articles related to Eye Disease:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Elevated levels of multiple biomarkers of Alzheimer's disease in the aqueous humor of eyes with open-angle glaucoma. (23860758)
2013
2
The Eyes Absent proteins in development and disease. (22971774)
2013
3
Treatment of refractory dry eye associated with graft versus host disease with 0.03% tacrolimus eyedrops. (23947579)
2013
4
Turn-over orbital septal flap and levator recession for upper-eyelid retraction secondary to thyroid eye disease. (23907627)
2013
5
Eyes on 3D-current 3D biomimetic disease concept models and potential applications in age-related macular degeneration. (24000403)
2013
6
Is blinking of the eyes affected in extrapyramidal disorders? An interesting observation in a patient with Wilson disease. (23188863)
2012
7
'The eyes see what the mind knows.' Adult-onset Still's disease, a case series and review in a south Asian population. (23083054)
2012
8
Wavy and elevated retinal pigment epithelial line in optical coherence tomographic images of eyes with atypical Vogt-Koyanagi-Harada disease. (22395203)
2012
9
Water outage increases the risk of gastroenteritis and eyes and skin diseases. (21943080)
2011
10
Eyes open to stem cells: safety trial may pave the way for cell therapy to treat retinal disease in patients. (22152341)
2011
11
I've been seeing tiny, random black specks in front of my eyes. Could this be some kind of eye disease, like macular degeneration? (21714174)
2011
12
A review of surgical techniques to correct upper eyelid retraction associated with thyroid eye disease. (21730842)
2011
13
Transcutaneous dysport injection for treatment of upper eyelid retraction associated with thyroid eye disease. (20394553)
2010
14
Cutaneous Rosai-Dorfman disease: presenting as massive bilateral eyelid swelling. (19840336)
2009
15
Kimura disease of the eyelid in an Indian man. (19594570)
2009
16
Metastatic eyelid disease associated with primary breast carcinoma: case report. (19668974)
2009
17
Can autoimmunity against calsequestrin explain the eye and eyelid muscle inflammation of thyroid eye disease? (19839885)
2009
18
Increase of frequency in deep brain stimulation relieves apraxia of eyelid opening in patients with Parkinson's disease: case report. (19057285)
2008
19
Isolated upper eyelid retraction: a sign of idiopathic inflammatory orbital disease. (18209649)
2008
20
Graded full-thickness anterior blepharotomy for correction of upper eyelid retraction not associated with thyroid eye disease. (17237689)
2007
21
Evaluation of retinal status using chromatic pupil light reflex activity in healthy and diseased canine eyes. (17962471)
2007
22
Molecular pathology of eyes with von Hippel-Lindau (VHL) Disease: a review. (17218907)
2007
23
Botulinum toxin A injections improve apraxia of eyelid opening without overt blepharospasm associated with neurodegenerative diseases. (17266083)
2007
24
Human secretory phospholipase A(2), group IB in normal eyes and in eye diseases. (17488462)
2007
25
High-resolution in vivo imaging of the RPE mosaic in eyes with retinal disease. (17460294)
2007
26
Rosai-Dorfman disease presenting as bilateral eyelid swellings. (16484848)
2006
27
Defining the human macula transcriptome and candidate retinal disease genes using EyeSAGE. (16723438)
2006
28
Kimura disease of the eyelid: a clinicopathologic study with electron microscopic observations. (17117118)
2006
29
Acquired lower eyelid epiblepharon in patients with thyroid eye disease. (15942493)
2005
30
Pattern visual evoked potentials in eyes with disc swelling due to cat scratch disease-associated neuroretinitis. (16328936)
2005
31
Treatment of atopic eyelid disease using topical tacrolimus following corticosteroid discontinuation in a patient with open-angle glaucoma. (15502487)
2004
32
Ultrastructural changes in rat eyes with experimental Vogt-Koyanagi-Harada disease. (15175913)
2004
33
Decreased levels of pigment epithelium-derived factor in eyes with neuroretinal dystrophic diseases. (15183804)
2004
34
Incidence of retinal disease following refractive surgery in 9,239 eyes. (14518742)
2003
35
Topical tacrolimus treatment of atopic eyelid disease. (12614745)
2003
36
Prion protein accumulation in eyes of patients with sporadic and variant Creutzfeldt-Jakob disease. (12506094)
2003
37
Successful treatment of the paralyzed lower eyelid due to Hansen's disease by implanting auricular cartilage. (12120042)
2002
38
Apraxia of eyelid closure in Huntington's disease. (12075860)
2002
39
Six-year disease-free survival of a patient with metastatic eyelid squamous cell carcinoma and colon adenocarcinoma after repeated postoperative adoptive immunotherapy. (10939431)
2000
40
"The eyes have it": trachoma, the perception of disease, the United States Public Health Service, and the American Jewish immigration experience, 1897-1924. (11016097)
2000
41
Eyelid dystonia in Machado-Joseph disease. (11009223)
2000
42
Correlation of the Schirmer 1 and fluorescein clearance tests with the severity of corneal epithelial and eyelid disease. (11115257)
2000
43
Fixation patterns and reading rates in eyes with central scotomas from advanced atrophic age-related macular degeneration and Stargardt disease. (8841306)
1996
44
Metastatic eyelid disease. (3627715)
1987
45
Mycobacterium fortuitum as a cause for nasolacrimal obstruction and granulomatous eyelid disease. (3574874)
1987
46
The eyes of Woodrow Wilson. Retinal vascular disease and George de Schweinitz. (3887267)
1985
47
Preventing eyelid disease. (6455407)
1981
48
Apollo 11 disease or acute hemorrhagic conjunctivitis: a pandemic of a new enterovirus infection of the eyes. (1130401)
1975
49
Flutterlike oscillations of the eyes in cerebellar disease. (13948686)
1963
50
Effect of naphazoline on acute iridocyclitis; effect of naphazoline on episcleritis; effect of naphazoline on contusion of the eyeball and on some other eye diseases (conjunctivitis, keratitis herpetica). (13388270)
1956

Genetic Variations for Eye Disease

Expression for genes affiliated with Eye Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Eye Disease

Search GEO for disease gene expression data for Eye Disease.

Pathways for genes affiliated with Eye Disease

Sources:
50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 30KEGG
See all sources

Compounds for genes affiliated with Eye Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Eye Disease according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1triacylglycerol4510.9GK, LCAT, APOA1, APOA2
2p-opc4510.9APOA2, APOA1, LCAT
3dimyristoylphosphatidylcholine4510.9APOA2, APOA1, LCAT
4intralipid4510.9LCAT, APOA1, APOA2
5pdpc4510.8APOA1, LCAT
6cholesterol ester4510.8LCAT, APOA1, APOA2
7torcetrapib4510.8APOA1, LCAT
8bezafibrate45 29 1112.8APOA2, APOA1, LCAT
9plpc4510.8APOA1, LCAT
10lecithin4510.7LCAT, APOA2
11(+-)-bay k 86446010.7CACNA1F, OA2
12nnc 55-0396 dihydrochloride6010.7CACNA1F, OA2
13mibefradil dihydrochloride6010.6CACNA1F, OA2
14probucol45 1111.6APOA1, LCAT
15omega-conotoxin gvia6010.6CACNA1F, OA2
16pregabalin60 45 1112.5CACNA1F, OA2
17retinyl palmitate45 2411.3APOA1, LCAT

GO Terms for genes affiliated with Eye Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Eye Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particleGO:03436110.6APOA2, APOA1
2high-density lipoprotein particleGO:03436410.5APOA2, APOA1, LCAT
3spherical high-density lipoprotein particleGO:03436610.3APOA2, APOA1

Biological processes related to Eye Disease according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760111.1OAT, RS1, NYX, ROM1, RDH8, NDP
2high-density lipoprotein particle remodelingGO:03437510.9LCAT, APOA1, APOA2
3reverse cholesterol transportGO:04369110.9APOA2, APOA1, LCAT
4phosphatidylcholine biosynthetic processGO:00665610.9LCAT, APOA1, APOA2
5lipoprotein metabolic processGO:04215710.9LCAT, APOA1, APOA2
6negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.9APOA2, APOA1
7negative regulation of lipase activityGO:06019210.9APOA2, APOA1
8regulation of intestinal cholesterol absorptionGO:03030010.9APOA2, APOA1
9lipoprotein biosynthetic processGO:04215810.9LCAT, APOA1
10cholesterol homeostasisGO:04263210.8LCAT, APOA1, APOA2
11high-density lipoprotein particle assemblyGO:03438010.8APOA1, APOA2
12protein oxidationGO:01815810.8APOA1, APOA2
13retinoid metabolic processGO:00152310.8APOA1, APOA2, RDH8
14negative regulation of cytokine secretion involved in immune responseGO:00274010.8APOA1, APOA2
15peptidyl-methionine modificationGO:01820610.8APOA2, APOA1
16high-density lipoprotein particle clearanceGO:03438410.7APOA2, APOA1
17cholesterol metabolic processGO:00820310.7APOA2, APOA1, LCAT
18positive regulation of cholesterol esterificationGO:01087310.7APOA1, APOA2
19phospholipid effluxGO:03370010.6APOA2, APOA1
20cellular lipid metabolic processGO:04425510.6APOA2, APOA1, GK
21phototransduction, visible lightGO:00760310.6APOA1, APOA2, RDH8
22cholesterol transportGO:03030110.5APOA1, LCAT
23cholesterol effluxGO:03334410.3APOA2, APOA1

Molecular functions related to Eye Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apolipoprotein receptor bindingGO:03419010.7APOA2, APOA1
2high-density lipoprotein particle receptor bindingGO:07065310.6APOA2, APOA1
3phosphatidylcholine-sterol O-acyltransferase activator activityGO:06022810.6APOA1, APOA2
4cholesterol transporter activityGO:01712710.6APOA2, APOA1
5lipase inhibitor activityGO:05510210.5APOA1, APOA2
6high-density lipoprotein particle bindingGO:00803510.3APOA2, APOA1

Products for genes affiliated with Eye Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eye Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet