MCID: EYD002
MIFTS: 59

Eye Disease malady

Eye diseases category
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Summaries for Eye Disease

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MedlinePlus:33 Your eyes can get infections from bacteria, fungi, or viruses. eye infections can occur in different parts of the eye and can affect just one eye or both. two common eye infections are conjunctivitis - also known as pinkeye. conjunctivitis is often due to an infection. children frequently get it, and it is very contagious. stye - a bump on the eyelid that happens when bacteria from your skin get into the hair follicle of an eyelash. symptoms of eye infections may include redness, itching, swelling, discharge, pain, or problems with vision. treatment depends on the cause of the infection and may include compresses, eye drops, creams, or antibiotics.

MalaCards based summary: Eye Disease, also known as eye infections, is related to fish-eye disease and blindness. An important gene associated with Eye Disease is CACNA1F (calcium channel, voltage-dependent, L type, alpha 1F subunit), and among its related pathways are Selected targets of HNF1 and Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF . The drugs prednisone and prednisone pwdr and the compounds pdpc and lecithin have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and skin, and related mouse phenotype vision/eye.

Aliases & Classifications for Eye Disease

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Eye Disease, Aliases & Descriptions:

Name: Eye Disease 8
Eye Infections 33 62
 
Disorder of Eye 62
Eye Infection 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Related Diseases for Eye Disease

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Diseases related to Eye Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1232)
idRelated DiseaseScoreTop Affiliating Genes
1fish-eye disease31.3APOA1, APOA2, LCAT
2blindness31.2OAT
3astigmatism30.8CACNA1F
4hyperopia30.7CACNA1F
5congenital stationary night blindness30.4NYX, CACNA1F
6spiradenoma30.3LCAT, GK, OAT
7tangier disease30.2LCAT, APOA2, APOA1
8norum disease30.1APOA1, APOA2, LCAT
9arcus senilis30.1LCAT, APOA1
10hypoalphalipoproteinemia30.1APOA1, APOA2, LCAT
11night blindness30.1CACNA1F, RP2, NYX
12hereditary night blindness30.1NYX, CACNA1F
13oguchi disease 130.1CACNA1F, NYX
14abetalipoproteinemia30.0APOA1, LCAT
15alagille syndrome30.0LCAT, APOA1
16fundus dystrophy29.9NPHP1, ROM1
17myopia 629.8NYX, RP2, CACNA1F
18type 2 diabetes mellitus29.7LCAT, APOA2, APOA1
19diabetes mellitus29.6GK, APOA1, APOA2, LCAT
20retinal degeneration29.6OAT, RP2, ROM1, NPHP1
21rhyns syndrome29.6RP2, ROM1, NPHP1
22aland island eye disease29.5CACNA1F, RP2, ZNF41, ZNF81, NYX, GK
23thyroiditis10.8
24age related macular degeneration10.4
25cataract10.3
26x-linked congenital stationary night blindness10.3NYX, CACNA1F
27amyloidosis, secondary10.3LCAT, APOA1
28hypobetalipoproteinemia10.3APOA1, LCAT
29herpes simplex10.3
30keratitis10.3
31amyloidosis, renal10.3APOA2, APOA1
32familial hypertriglyceridemia10.3APOA2, APOA1
33strabismus10.3
34familial hypercholesterolemia10.3APOA1, LCAT
35refractive error10.2
36complete lcat deficiency10.2APOA1, APOA2, LCAT
37hyperalphalipoproteinemia10.2APOA1, APOA2, LCAT
38familial combined hyperlipidemia10.2APOA1, APOA2, LCAT
39familial hyperlipidemia10.2APOA1, APOA2, LCAT
40hypercholesterolemia10.2LCAT, APOA2, APOA1
41hyperinsulinism10.1LCAT, APOA2, APOA1
42iridocyclitis10.1
43myopia10.1
44retinal disease10.1
45stromal keratitis10.1
46proteinuria10.1LCAT, APOA2, APOA1
47keratoconjunctivitis10.1
48retinitis10.1
49chronic kidney failure10.1APOA1, LCAT, NPHP1
50coronary artery anomaly10.1LCAT, APOA2, APOA1

Graphical network of the top 20 diseases related to Eye Disease:



Diseases related to eye disease

Symptoms for Eye Disease

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Drugs & Therapeutics for Eye Disease

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Drug clinical trials:

Search ClinicalTrials for Eye Disease

Search NIH Clinical Center for Eye Disease

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Eye Disease

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Anatomical Context for Eye Disease

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MalaCards organs/tissues related to Eye Disease:

32
Eye, Thyroid, Skin, Testes, Endothelial, T cells, Bone, Liver, B cells, Brain, Retina, Adipocyte, Kidney, Nk cells, Neutrophil

Animal Models for Eye Disease or affiliated genes

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MGI Mouse Phenotypes related to Eye Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5NPHP1, ROM1, CACNA1F, LCAT, NYX, OAT

Publications for Eye Disease

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Articles related to Eye Disease:

(show top 50)    (show all 637)
idTitleAuthorsYear
1
Vision for improvement: Expressive writing as an intervention for people with Stargardt's disease, a rare eye disease. (24934432)
2014
2
Color vision deficiency in preschool children: the multi-ethnic pediatric eye disease study. (24702753)
2014
3
Sight-threatening diabetic eye disease: an update and review of the literature. (25267057)
2014
4
Risk factors for loss of visual acuity among patients with uveitis associated with juvenile idiopathic arthritis: the Systemic Immunosuppressive Therapy for Eye Diseases Study. (23062650)
2013
5
Detecting the Progression of Eye Disease: CUSUM Charts for Assessing the Visual Field and Retinal Nerve Fiber Layer Thickness. (24083087)
2013
6
Laser, intravitreal drug application, and surgery to treat diabetic eye disease. (24391369)
2013
7
Chemokine Receptors CCR6 and CXCR3 Are Necessary for CD4(+) T Cell Mediated Ocular Surface Disease in Experimental Dry Eye Disease. (24223818)
2013
8
Cataract, visual impairment and long-term mortality in a rural cohort in India: the Andhra Pradesh Eye Disease Study. (24282482)
2013
9
Influence of a controlled environment simulating an in-flight airplane cabin on dry eye disease. (23412090)
2013
10
Light-induced retinal degeneration is prevented by zinc, a component in the age-related eye disease study formulation. (22385127)
2012
11
Dry eye disease: an immune-mediated ocular surface disorder. (22232476)
2012
12
Blockade of prolymphangiogenic vascular endothelial growth factor C in dry eye disease. (21911653)
2012
13
Epidemiology of major eye diseases leading to blindness in Europe: a literature review. (22123077)
2012
14
There are people in Australia who have poor vision or eye disease that is avoidable. What more can we do? (23106402)
2012
15
Expression of CCR5 and its ligands CCL3, -4, and -5 in the tear film and ocular surface of patients with dry eye disease. (22029739)
2012
16
Michelangelo's eye disease. (22425178)
2012
17
Interferon-I^-secreting NK cells promote induction of dry eye disease. (21402771)
2011
18
Biologic agents in inflammatory eye disease. (22454752)
2011
19
Quality of life in thyroid eye disease: impact of quality of care. (21367964)
2011
20
Disturbed apolipoprotein A-I-containing lipoproteins in fish-eye disease are improved by the lecithin:cholesterol acyltransferase produced by gene-transduced adipocytes in vitro. (21074466)
2011
21
Onset of inflammatory eye disease under tocilizumab treatment for rheumatologic conditions: a paradoxical effect? (21965707)
2011
22
Lipid metabolites in the pathogenesis and treatment of neovascular eye disease. (21421650)
2011
23
Prevalence and risk factors for visual impairment in preschool children the sydney paediatric eye disease study. (21529955)
2011
24
The economic burden of dry eye disease in the United States: a decision tree analysis. (21045640)
2011
25
Calorie restriction: A new therapeutic intervention for age-related dry eye disease in rats. (20537981)
2010
26
Regulation of the inflammatory component in chronic dry eye disease by the eye-associated lymphoid tissue (EALT). (20502024)
2010
27
Radiologically manifested accessory extraocular muscles in thyroid eye disease. (20502362)
2010
28
Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study. (21197116)
2010
29
Attitudes towards diagnostic tests and therapies for dry eye disease. (19829007)
2010
30
Transcutaneous dysport injection for treatment of upper eyelid retraction associated with thyroid eye disease. (20394553)
2010
31
Recurrent orbital myositis with radiological feature mimicking thyroid eye disease in a patient with Crohn's disease. (19929661)
2009
32
Description of the Age-Related Eye Disease Study 9-step severity scale applied to participants in the Complications of Age-related Macular Degeneration Prevention Trial. (19752423)
2009
33
Visual acuity outcomes after cataract surgery in patients with age-related macular degeneration: age-related eye disease study report no. 27. (19700198)
2009
34
Legacy of the age-related eye disease [corrected] study. (20008728)
2009
35
Prevalence of dry eye disease among Japanese visual display terminal users. (18708259)
2008
36
Advances in understanding and managing dry eye disease. (18599017)
2008
37
Knowledge of diabetic eye disease and vision care guidelines among Hispanic individuals in Baltimore with and without diabetes. (18625945)
2008
38
Will vaccination against human papillomavirus prevent eye disease? A review of the evidence. (18369059)
2008
39
Association between dietary glycemic index and age-related macular degeneration in nondiabetic participants in the Age-Related Eye Disease Study. (17616779)
2007
40
Corneal striae in thyroid eye disease. (17277745)
2007
41
Multivitamin-multimineral supplements and eye disease: age-related macular degeneration and cataract. (17209215)
2007
42
Eye disease and care at hospital clinics in Cook Islands, Fiji, Samoa and Tonga. (17894682)
2007
43
Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-related Eye Disease Study (CAREDS): ancillary study of the Women's Health Initiative. (16908818)
2006
44
T13M mutation of lecithin-cholesterol acyltransferase gene causes fish-eye disease. (15115696)
2004
45
Expression of human beta-defensins in conjunctival epithelium: relevance to dry eye disease. (12939294)
2003
46
Vascular endothelial growth factors and angiogenesis in eye disease. (12597922)
2003
47
The role of octreoscan in thyroid eye disease. (10229898)
1999
48
Role of the eye muscles in thyroid eye disease: identification of the principal autoantigens. (9669297)
1998
49
Negative-configuration electroretinogram in Oregon eye disease. Consistent phenotype in Xp21 deletion syndrome. (8240114)
1993
50
Localization of the Aland Island eye disease locus to the pericentromeric region of the X chromosome by linkage analysis. (1985461)
1991

Variations for Eye Disease

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Expression for genes affiliated with Eye Disease

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Expression patterns in normal tissues for genes affiliated with Eye Disease

Search GEO for disease gene expression data for Eye Disease.

Pathways for genes affiliated with Eye Disease

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Pathways related to Eye Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7APOA1, APOA2
29.7APOA1, APOA2
3
Show member pathways
9.4LCAT, APOA2, APOA1
4
Show member pathways
9.4APOA1, APOA2, LCAT
5
Show member pathways
9.1APOA2, APOA1, GK
6
Show member pathways
fatty acid beta-oxidation VI (peroxisome)37
9.1APOA2, APOA1, GK
7
Show member pathways
8.4LCAT, APOA2, APOA1, GK, OAT

Compounds for genes affiliated with Eye Disease

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 50PharmGKB
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Compounds related to Eye Disease according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1pdpc4410.1LCAT, APOA1
2lecithin4410.1LCAT, APOA2
3torcetrapib4410.1APOA1, LCAT
4plpc4410.1APOA1, LCAT
5retinyl palmitate44 2411.1LCAT, APOA1
6probucol44 1111.0LCAT, APOA1
7guanidine44 24 1111.9LCAT, APOA1
8gemfibrozil28 44 1111.9APOA1, APOA2
9mspi449.9APOA2, APOA1
10acetaldehyde28 44 2411.9LCAT, APOA1
11p-opc449.8LCAT, APOA2, APOA1
12dimyristoylphosphatidylcholine449.8APOA1, APOA2, LCAT
13intralipid449.7LCAT, APOA2, APOA1
14cholesterol ester449.7APOA1, APOA2, LCAT
15bezafibrate44 28 1111.7LCAT, APOA2, APOA1
16fenofibrate44 50 1111.7APOA2, APOA1
17phosphatidylcholine449.7APOA1, APOA2, LCAT
18phospholipid449.5APOA1, APOA2, LCAT
19phosphoenolpyruvate44 1110.4OAT, GK
20cholesterol44 28 24 1112.3ROM1, LCAT, APOA2, APOA1
21fatty acid449.2LCAT, APOA2, GK
22glutamine449.2LCAT, APOA2, OAT
23triacylglycerol449.1LCAT, APOA2, APOA1, GK

GO Terms for genes affiliated with Eye Disease

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Cellular components related to Eye Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particleGO:0343619.7APOA2, APOA1
2spherical high-density lipoprotein particleGO:0343669.4APOA2, APOA1
3high-density lipoprotein particleGO:0343649.3LCAT, APOA2, APOA1

Biological processes related to Eye Disease according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein biosynthetic processGO:04215810.1APOA1, LCAT
2negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.0APOA2, APOA1
3negative regulation of lipase activityGO:06019210.0APOA2, APOA1
4regulation of intestinal cholesterol absorptionGO:03030010.0APOA1, APOA2
5high-density lipoprotein particle assemblyGO:03438010.0APOA1, APOA2
6protein oxidationGO:01815810.0APOA1, APOA2
7cholesterol transportGO:03030110.0LCAT, APOA1
8negative regulation of cytokine secretion involved in immune responseGO:00274010.0APOA1, APOA2
9peptidyl-methionine modificationGO:01820610.0APOA2, APOA1
10high-density lipoprotein particle clearanceGO:0343849.9APOA2, APOA1
11positive regulation of cholesterol esterificationGO:0108739.9APOA1, APOA2
12phospholipid effluxGO:0337009.9APOA2, APOA1
13cholesterol effluxGO:0333449.8APOA1, APOA2
14retina development in camera-type eyeGO:0600419.8NPHP1, CACNA1F
15high-density lipoprotein particle remodelingGO:0343759.8APOA1, APOA2, LCAT
16reverse cholesterol transportGO:0436919.8LCAT, APOA2, APOA1
17phosphatidylcholine biosynthetic processGO:0066569.8LCAT, APOA2, APOA1
18lipoprotein metabolic processGO:0421579.8APOA1, APOA2, LCAT
19cholesterol homeostasisGO:0426329.7LCAT, APOA2, APOA1
20cholesterol metabolic processGO:0082039.7LCAT, APOA2, APOA1
21organ regenerationGO:0311009.7APOA1, APOA2
22response to estrogenGO:0436279.7APOA2, APOA1
23triglyceride metabolic processGO:0066419.5APOA2, GK
24retinoid metabolic processGO:0015239.4APOA2, APOA1
25cellular lipid metabolic processGO:0442559.2APOA2, APOA1, GK
26visual perceptionGO:0076018.7ROM1, CACNA1F, RP2, NYX, OAT
27small molecule metabolic processGO:0442818.6LCAT, APOA2, APOA1, GK, OAT

Molecular functions related to Eye Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1apolipoprotein receptor bindingGO:0341909.9APOA2, APOA1
2high-density lipoprotein particle receptor bindingGO:0706539.8APOA2, APOA1
3phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.8APOA2, APOA1
4lipase inhibitor activityGO:0551029.8APOA2, APOA1
5high-density lipoprotein particle bindingGO:0080359.7APOA1, APOA2
6phospholipid bindingGO:0055439.7APOA2, APOA1
7cholesterol transporter activityGO:0171279.6APOA2, APOA1
8cholesterol bindingGO:0154859.4APOA2, APOA1

Products for genes affiliated with Eye Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Eye Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet