MCID: EYD002
MIFTS: 60

Eye Disease malady

Eye diseases category

Summaries for Eye Disease

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Some eye problems are minor and don't last long. but some can lead to a permanent loss of vision. common eye problems include refractive errors cataracts - clouded lenses glaucoma - a disorder caused by damage to the optic nerve retinal disorders - problems with the nerve layer at the back of the eye macular degeneration - a disease that destroys sharp, central vision diabetic eye problems conjunctivitis - an infection also known as pinkeye your best defense is to have regular checkups, because eye diseases do not always have symptoms. early detection and treatment could prevent vision loss. see an eye care professional right away if you have a sudden change in vision, if everything looks dim, or if you see flashes of light. other symptoms that need quick attention are pain, double vision, fluid coming from the eye, and inflammation. nih: national eye institute

MalaCards: Eye Disease, also known as eye infections, is related to fish-eye disease and aland island eye disease. An important gene associated with Eye Disease is CACNA1F (calcium channel, voltage-dependent, L type, alpha 1F subunit), and among its related pathways are Statin Pathway, Pharmacodynamics and Lipoprotein metabolism. The drugs prednisone and prednisone pwdr and the compounds triacylglycerol and p-opc have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and brain, and related mouse phenotypes are pigmentation and vision/eye.

Wikipedia:63 This is a partial list of human eye diseases and disorders. more...

Aliases & Classifications for Eye Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

eye disease 8 10
eye infections 33 60
eye diseases 44 33
disorder of eye 60
eye infection 8


Related Diseases for Eye Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Eye Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1fish-eye disease30.7APOA1, APOA2, LCAT
2aland island eye disease30.6OA2, NYX, ZNF41, CACNA1F, GK
3age related macular degeneration30.6RS1
4retinal disease30.3NYX, ROM1, RS1, NDP, CACNA1F
5astigmatism30.1CACNA1F
6night blindness30.0NYX, CACNA1F
7norum disease29.8APOA2, LCAT, APOA1
8tangier disease29.8APOA1, LCAT, APOA2
9congenital stationary night blindness29.8CACNA1F, NYX
10retinal degeneration29.6RS1, ROM1, NPHP1, RDH8, OAT
11retinoschisis29.6RS1
12thyroiditis10.8
13orbital disease10.4
14cataract10.4
15corneal disease10.3
16herpes simplex10.3
17keratitis10.3
18eyelid disease10.2
19strabismus10.2
20refractive error10.2
21abnormal pupillary function10.2
22scarring in glaucoma filtration surgical procedures10.1
23conjunctival disease10.1
24dry eye syndrome10.1
25glaucoma10.1
26myopia10.1
27retinitis10.1
28autoimmune thyroiditis10.1
29graves' disease10.1
30vascular disease10.1
31vitreous disease10.1
32ocular motility disease10.0
33amblyopia10.0
34chromosomal disease10.0
35diabetic retinopathy10.0
36iridocyclitis10.0
37keratoconjunctivitis10.0
38neuropathy10.0
39pigmentation disease10.0
40scleritis10.0
41x-linked cone dysfunction syndrome with myopia10.0
42blindness10.0NDP, RS1, OAT
43complete lcat deficiency10.0LCAT, APOA1, APOA2
44hypoalphalipoproteinemia10.0APOA1, LCAT, APOA2
45hyperalphalipoproteinemia10.0APOA2, APOA1, LCAT
46myopia 610.0NYX, RDH8, CACNA1F
47hypertriglyceridemia10.0APOA2, APOA1, GK, LCAT
48rhyns syndrome10.0NPHP1, ROM1, RS1
49metabolic syndrome x10.0GK, APOA1, OAT, LCAT
50familial combined hyperlipidemia10.0APOA1, LCAT, APOA2

Graphical network of the top 20 diseases related to Eye Disease:



Diseases related to eye disease

Clinical Features for Eye Disease

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Drugs & Therapeutics for Eye Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Eye Disease

Drug clinical trials:

Search ClinicalTrials for Eye Disease

Search NIH Clinical Center for Eye Disease

Search CenterWatch for Eye Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Eye Disease

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Anatomical Context for Eye Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Eye Disease:

32
Eye, Thyroid, Brain, Testes, Endothelial, Skin, T cells, Liver, Bone, B cells, Trachea, Nk cells, Retina, Adipocyte, Skeletal muscle, Heart, Lung, Kidney, Cortex

Animal Models for Eye Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Eye Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.6NDP, RDH8, RS1, OAT
2MP:000539110.6LCAT, CACNA1F, NDP, NPHP1, RDH8, OPTC

Publications for Eye Disease

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Sources:
50PubMed
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Articles related to Eye Disease:

(show top 50)    (show all 791)
idTitleAuthorsYear
1
Twin studies in inherited eye disease. (24118999)
2014
2
Peripheral retinal nonperfusion in fellow eyes in coats disease. (23974953)
2013
3
Surfactant protein D contributes to ocular defense against Pseudomonas aeruginosa in a murine model of dry eye disease. (23762428)
2013
4
Ocular surface changes in thyroid eye disease. (23565763)
2013
5
How much eye care services do Asian populations need? Projection from the Singapore Epidemiology of Eye Disease (SEED) study. (23439593)
2013
6
Local therapies for inflammatory eye disease in translation: past, present and future. (23914773)
2013
7
Necrotizing scleritis after strabismus surgery in thyroid eye disease. (24160978)
2013
8
Symptom burden of patients with dry eye disease: a four domain analysis. (24349365)
2013
9
Tremor of the eyes, or of the head, in Parkinson's disease? (23629728)
2013
10
Orbital radiotherapy for adult thyroid eye disease. (22786503)
2012
11
Correlations between tear cytokines, chemokines, and soluble receptors and clinical severity of dry eye disease. (22789923)
2012
12
Ocular surface immunity: homeostatic mechanisms and their disruption in dry eye disease. (22426080)
2012
13
Correlation between optical coherence tomography-derived assessments of lower tear meniscus parameters and clinical features of dry eye disease. (22378111)
2012
14
Novel POMGNT1 point mutations and intragenic rearrangements associated with muscle-eye-brain disease. (22554691)
2012
15
Scleritis: a paradoxical effect of etanercept? Etanercept-associated inflammatory eye disease. (22174213)
2012
16
Clinical and histopathological features of a suspected case of fish-eye disease. (22855019)
2012
17
In vivo characterisation of a novel water-soluble Cyclosporine A prodrug for the treatment of dry eye disease. (22155591)
2012
18
The dry eye disease activity log study. (23193384)
2012
19
Molecular and cellular biomarkers in dry eye disease and ocular allergy. (22895048)
2012
20
Multiple retinal holes and peripheral nonperfusion in muscle-eye-brain disease. (21403000)
2011
21
Tear osmolarity in the diagnosis and management of dry eye disease. (21310379)
2011
22
Correlation between extraocular muscle size and motility restriction in thyroid eye disease. (21383547)
2011
23
Effects of cerebellar disease on sequences of rapid eye movements. (21385592)
2011
24
Disease impact in chronic progressive external ophthalmoplegia: more than meets the eye. (21236670)
2011
25
Prevalence of dry eye disease in Mongolians at high altitude in China: the Henan eye study. (20642346)
2010
26
Thyroid eye disease: pathogenesis and treatment. (19940525)
2010
27
First signs of glaucoma injury occur in the brain. What has generally been considered an eye disease is actually related to conditions such as Alzheimer's and Parkinson's diseases. (20518132)
2010
28
Tear proteomics in evaporative dry eye disease. (20150925)
2010
29
Cold-sensitive corneal afferents respond to a variety of ocular stimuli central to tear production: implications for dry eye disease. (20335617)
2010
30
Current clinical practice of consultant ophthalmologists in treating herpetic eye disease in the United Kingdom. (18344961)
2009
31
Dietary compound score and risk of age-related macular degeneration in the age-related eye disease study. (19410952)
2009
32
Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health Initiative. (18332316)
2008
33
Angiogenesis in eye disease: immunity gained or immunity lost? (18297288)
2008
34
Severe muscle-eye-brain disease is associated with a homozygous mutation in the POMGnT1 gene. (17881266)
2008
35
Eye disease and care at hospital clinics in Cook Islands, Fiji, Samoa and Tonga. (17894682)
2007
36
Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-related Eye Disease Study (CAREDS): ancillary study of the Women's Health Initiative. (16908818)
2006
37
Is dry eye syndrome a work-related disease among radiologists? (17160796)
2006
38
Acquired lower eyelid epiblepharon in patients with thyroid eye disease. (15942493)
2005
39
VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and VelociGene- based discovery of the next generation of angiogenesis targets. (16869778)
2005
40
Review: effects of nitric oxide on eye diseases and their treatment. (11324986)
2001
41
"The eyes have it": trachoma, the perception of disease, the United States Public Health Service, and the American Jewish immigration experience, 1897-1924. (11016097)
2000
42
Muscle membrane-skeleton protein changes and histopathological characterization of muscle-eye-brain disease. (10677859)
2000
43
Clinical course of macular holes: the Eye Disease Case-Control Study. (10037571)
1999
44
A controlled trial of oral acyclovir for iridocyclitis caused by herpes simplex virus. The Herpetic Eye Disease Study Group. (8790090)
1996
45
Muscle-eye-brain disease and Walker-Warburg syndrome: phenotype-genotype speculations. Commentary to Pihko's paper (pp. 57-61) (7762766)
1995
46
Negative-configuration electroretinogram in Oregon eye disease. Consistent phenotype in Xp21 deletion syndrome. (8240114)
1993
47
Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye disease. Studies in nondiabetic and diabetic subjects. (7504689)
1993
48
Aland Island eye disease (Forsius-Eriksson syndrome) associated with contiguous deletion syndrome at Xp21. Similarity to incomplete congenital stationary night blindness. (2667510)
1989
49
Different substrate specificities of plasma lecithin: cholesterol acyl transferase in fish eye disease and Tangier disease. (3425387)
1987
50
Plasma apolipoprotein pattern in fish-eye disease examined by high-resolution two-dimensional electrophoresis. (3933853)
1985

Genetic Variations for Eye Disease

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Expression for genes affiliated with Eye Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eye Disease

Search GEO for disease gene expression data for Eye Disease.

Pathways for genes affiliated with Eye Disease

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 29KEGG
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Compounds for genes affiliated with Eye Disease

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Eye Disease according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1triacylglycerol4410.9GK, LCAT, APOA1, APOA2
2p-opc4410.9APOA2, APOA1, LCAT
3dimyristoylphosphatidylcholine4410.9APOA2, APOA1, LCAT
4intralipid4410.9LCAT, APOA1, APOA2
5pdpc4410.8APOA1, LCAT
6cholesterol ester4410.8LCAT, APOA1, APOA2
7torcetrapib4410.8APOA1, LCAT
8bezafibrate44 28 1112.8APOA2, APOA1, LCAT
9plpc4410.8APOA1, LCAT
10lecithin4410.7LCAT, APOA2
11(+-)-bay k 86445910.7CACNA1F, OA2
12nnc 55-0396 dihydrochloride5910.7CACNA1F, OA2
13mibefradil dihydrochloride5910.6CACNA1F, OA2
14probucol44 1111.6APOA1, LCAT
15omega-conotoxin gvia5910.6CACNA1F, OA2
16pregabalin59 44 1112.5CACNA1F, OA2
17retinyl palmitate44 2411.3APOA1, LCAT

GO Terms for genes affiliated with Eye Disease

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16Gene Ontology
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Cellular components related to Eye Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particleGO:03436110.6APOA2, APOA1
2high-density lipoprotein particleGO:03436410.5APOA2, APOA1, LCAT
3spherical high-density lipoprotein particleGO:03436610.3APOA2, APOA1

Biological processes related to Eye Disease according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760111.1OAT, RS1, NYX, ROM1, RDH8, NDP
2high-density lipoprotein particle remodelingGO:03437510.9LCAT, APOA1, APOA2
3reverse cholesterol transportGO:04369110.9APOA2, APOA1, LCAT
4phosphatidylcholine biosynthetic processGO:00665610.9LCAT, APOA1, APOA2
5lipoprotein metabolic processGO:04215710.9LCAT, APOA1, APOA2
6negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.9APOA2, APOA1
7negative regulation of lipase activityGO:06019210.9APOA2, APOA1
8regulation of intestinal cholesterol absorptionGO:03030010.9APOA2, APOA1
9lipoprotein biosynthetic processGO:04215810.9LCAT, APOA1
10cholesterol homeostasisGO:04263210.8LCAT, APOA1, APOA2
11high-density lipoprotein particle assemblyGO:03438010.8APOA1, APOA2
12protein oxidationGO:01815810.8APOA1, APOA2
13retinoid metabolic processGO:00152310.8APOA1, APOA2, RDH8
14negative regulation of cytokine secretion involved in immune responseGO:00274010.8APOA1, APOA2
15peptidyl-methionine modificationGO:01820610.8APOA2, APOA1
16high-density lipoprotein particle clearanceGO:03438410.7APOA2, APOA1
17cholesterol metabolic processGO:00820310.7APOA2, APOA1, LCAT
18positive regulation of cholesterol esterificationGO:01087310.7APOA1, APOA2
19phospholipid effluxGO:03370010.6APOA2, APOA1
20cellular lipid metabolic processGO:04425510.6APOA2, APOA1, GK
21phototransduction, visible lightGO:00760310.6APOA1, APOA2, RDH8
22cholesterol transportGO:03030110.5APOA1, LCAT
23cholesterol effluxGO:03334410.3APOA2, APOA1

Molecular functions related to Eye Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apolipoprotein receptor bindingGO:03419010.7APOA2, APOA1
2high-density lipoprotein particle receptor bindingGO:07065310.6APOA2, APOA1
3phosphatidylcholine-sterol O-acyltransferase activator activityGO:06022810.6APOA1, APOA2
4cholesterol transporter activityGO:01712710.6APOA2, APOA1
5lipase inhibitor activityGO:05510210.5APOA1, APOA2
6high-density lipoprotein particle bindingGO:00803510.3APOA2, APOA1

Products for genes affiliated with Eye Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eye Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet