MCID: EYD002
MIFTS: 60

Eye Disease malady

Eye diseases category

Summaries for Eye Disease

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Some eye problems are minor and don't last long. but some can lead to a permanent loss of vision. common eye problems include refractive errors cataracts - clouded lenses glaucoma - a disorder caused by damage to the optic nerve retinal disorders - problems with the nerve layer at the back of the eye macular degeneration - a disease that destroys sharp, central vision diabetic eye problems conjunctivitis - an infection also known as pinkeye your best defense is to have regular checkups, because eye diseases do not always have symptoms. early detection and treatment could prevent vision loss. see an eye care professional right away if you have a sudden change in vision, if everything looks dim, or if you see flashes of light. other symptoms that need quick attention are pain, double vision, fluid coming from the eye, and inflammation. nih: national eye institute

MalaCards: Eye Disease, also known as eye infections, is related to fish-eye disease and blindness. An important gene associated with Eye Disease is CACNA1F (calcium channel, voltage-dependent, L type, alpha 1F subunit), and among its related pathways are Selected targets of HNF1 and Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF . The drugs prednisone and prednisone pwdr and the compounds pdpc and lecithin have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and testes, and related mouse phenotype vision/eye.

Wikipedia:66 This is a partial list of human eye diseases and disorders. more...

Aliases & Classifications for Eye Disease

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 28ICD9CM, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

eye disease 9 11
eye infections 35 63
eye diseases 46 35
disorder of eye 63
eye infection 9


Related Diseases for Eye Disease

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Eye Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1251)
idRelated DiseaseScoreTop Affiliating Genes
1fish-eye disease31.0APOA1, APOA2, LCAT
2blindness30.6OAT
3astigmatism30.3CACNA1F
4aland island eye disease30.3CACNA1F, RP2, ZNF41, ZNF81, NYX, GK
5hyperopia30.2CACNA1F
6night blindness30.1CACNA1F, RP2, NYX
7congenital stationary night blindness30.0NYX, CACNA1F
8norum disease30.0APOA1, APOA2, LCAT
9tangier disease30.0LCAT, APOA2, APOA1
10fundus dystrophy29.9NPHP1, ROM1
11hypoalphalipoproteinemia29.8APOA1, APOA2, LCAT
12diabetes mellitus29.7GK, APOA1, APOA2, LCAT
13retinal degeneration29.7OAT, RP2, ROM1, NPHP1
14arcus senilis29.7LCAT, APOA1
15hereditary night blindness29.7NYX, CACNA1F
16oguchi disease 129.7CACNA1F, NYX
17abetalipoproteinemia29.7APOA1, LCAT
18alagille syndrome29.7LCAT, APOA1
19type 2 diabetes mellitus29.6LCAT, APOA2, APOA1
20rhyns syndrome29.6RP2, ROM1, NPHP1
21myopia 629.5NYX, RP2, CACNA1F
22thyroiditis10.8
23age related macular degeneration10.3
24cataract10.3
25keratitis10.3
26herpes simplex10.3
27strabismus10.2
28glaucoma10.2
29refractive error10.2
30iridocyclitis10.1
31retinal disease10.1
32stromal keratitis10.1
33myopia10.1
34retinitis10.1
35x-linked congenital stationary night blindness10.1NYX, CACNA1F
36amyloidosis, secondary10.1LCAT, APOA1
37hypobetalipoproteinemia10.1APOA1, LCAT
38amyloidosis, renal10.1APOA2, APOA1
39familial hypertriglyceridemia10.1APOA2, APOA1
40familial hypercholesterolemia10.1APOA1, LCAT
41diabetic retinopathy10.1
42keratoconjunctivitis10.1
43lens disease10.1
44scleritis10.1
45endotheliitis10.1
46complete lcat deficiency10.0APOA1, APOA2, LCAT
47hyperalphalipoproteinemia10.0APOA1, APOA2, LCAT
48familial combined hyperlipidemia10.0APOA1, APOA2, LCAT
49familial hyperlipidemia10.0APOA1, APOA2, LCAT
50hypercholesterolemia10.0LCAT, APOA2, APOA1

Graphical network of the top 20 diseases related to Eye Disease:



Diseases related to eye disease

Symptoms for Eye Disease

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Drugs & Therapeutics for Eye Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Eye Disease

Drug clinical trials:

Search ClinicalTrials for Eye Disease

Search NIH Clinical Center for Eye Disease

Search CenterWatch for Eye Disease

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Eye Disease

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Anatomical Context for Eye Disease

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Sources:
34MalaCards
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MalaCards organs/tissues related to Eye Disease:

34
Eye, Thyroid, Testes, Endothelial, T cells, Bone, B cells, Liver, Adipocyte, Kidney, Retina, Brain, Nk cells

Animal Models for Eye Disease or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Eye Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5NPHP1, ROM1, CACNA1F, LCAT, NYX, OAT

Publications for Eye Disease

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Sources:
53PubMed
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Articles related to Eye Disease:

(show top 50)    (show all 609)
idTitleAuthorsYear
1
Risk factors for loss of visual acuity among patients with uveitis associated with juvenile idiopathic arthritis: the Systemic Immunosuppressive Therapy for Eye Diseases Study. (23062650)
2013
2
Detecting the Progression of Eye Disease: CUSUM Charts for Assessing the Visual Field and Retinal Nerve Fiber Layer Thickness. (24083087)
2013
3
Laser, intravitreal drug application, and surgery to treat diabetic eye disease. (24391369)
2013
4
Chemokine Receptors CCR6 and CXCR3 Are Necessary for CD4(+) T Cell Mediated Ocular Surface Disease in Experimental Dry Eye Disease. (24223818)
2013
5
Cataract, visual impairment and long-term mortality in a rural cohort in India: the Andhra Pradesh Eye Disease Study. (24282482)
2013
6
Influence of a controlled environment simulating an in-flight airplane cabin on dry eye disease. (23412090)
2013
7
Light-induced retinal degeneration is prevented by zinc, a component in the age-related eye disease study formulation. (22385127)
2012
8
Dry eye disease: an immune-mediated ocular surface disorder. (22232476)
2012
9
Blockade of prolymphangiogenic vascular endothelial growth factor C in dry eye disease. (21911653)
2012
10
Epidemiology of major eye diseases leading to blindness in Europe: a literature review. (22123077)
2012
11
There are people in Australia who have poor vision or eye disease that is avoidable. What more can we do? (23106402)
2012
12
Expression of CCR5 and its ligands CCL3, -4, and -5 in the tear film and ocular surface of patients with dry eye disease. (22029739)
2012
13
Michelangelo's eye disease. (22425178)
2012
14
Interferon-I^-secreting NK cells promote induction of dry eye disease. (21402771)
2011
15
Biologic agents in inflammatory eye disease. (22454752)
2011
16
Quality of life in thyroid eye disease: impact of quality of care. (21367964)
2011
17
Disturbed apolipoprotein A-I-containing lipoproteins in fish-eye disease are improved by the lecithin:cholesterol acyltransferase produced by gene-transduced adipocytes in vitro. (21074466)
2011
18
Onset of inflammatory eye disease under tocilizumab treatment for rheumatologic conditions: a paradoxical effect? (21965707)
2011
19
Lipid metabolites in the pathogenesis and treatment of neovascular eye disease. (21421650)
2011
20
Prevalence and risk factors for visual impairment in preschool children the sydney paediatric eye disease study. (21529955)
2011
21
The economic burden of dry eye disease in the United States: a decision tree analysis. (21045640)
2011
22
Calorie restriction: A new therapeutic intervention for age-related dry eye disease in rats. (20537981)
2010
23
Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease. (20371353)
2010
24
Regulation of the inflammatory component in chronic dry eye disease by the eye-associated lymphoid tissue (EALT). (20502024)
2010
25
Radiologically manifested accessory extraocular muscles in thyroid eye disease. (20502362)
2010
26
Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study. (21197116)
2010
27
Attitudes towards diagnostic tests and therapies for dry eye disease. (19829007)
2010
28
Transcutaneous dysport injection for treatment of upper eyelid retraction associated with thyroid eye disease. (20394553)
2010
29
Recurrent orbital myositis with radiological feature mimicking thyroid eye disease in a patient with Crohn's disease. (19929661)
2009
30
Description of the Age-Related Eye Disease Study 9-step severity scale applied to participants in the Complications of Age-related Macular Degeneration Prevention Trial. (19752423)
2009
31
Visual acuity outcomes after cataract surgery in patients with age-related macular degeneration: age-related eye disease study report no. 27. (19700198)
2009
32
Legacy of the age-related eye disease [corrected] study. (20008728)
2009
33
Prevalence of dry eye disease among Japanese visual display terminal users. (18708259)
2008
34
Advances in understanding and managing dry eye disease. (18599017)
2008
35
Knowledge of diabetic eye disease and vision care guidelines among Hispanic individuals in Baltimore with and without diabetes. (18625945)
2008
36
Will vaccination against human papillomavirus prevent eye disease? A review of the evidence. (18369059)
2008
37
Association between dietary glycemic index and age-related macular degeneration in nondiabetic participants in the Age-Related Eye Disease Study. (17616779)
2007
38
Corneal striae in thyroid eye disease. (17277745)
2007
39
Multivitamin-multimineral supplements and eye disease: age-related macular degeneration and cataract. (17209215)
2007
40
Eye disease and care at hospital clinics in Cook Islands, Fiji, Samoa and Tonga. (17894682)
2007
41
Blindness and eye disease in Cambodia. (18161609)
2007
42
Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-related Eye Disease Study (CAREDS): ancillary study of the Women's Health Initiative. (16908818)
2006
43
T13M mutation of lecithin-cholesterol acyltransferase gene causes fish-eye disease. (15115696)
2004
44
Expression of human beta-defensins in conjunctival epithelium: relevance to dry eye disease. (12939294)
2003
45
Vascular endothelial growth factors and angiogenesis in eye disease. (12597922)
2003
46
The role of octreoscan in thyroid eye disease. (10229898)
1999
47
Role of the eye muscles in thyroid eye disease: identification of the principal autoantigens. (9669297)
1998
48
Molecular basis of fish-eye disease in a patient from Spain. Characterization of a novel mutation in the LCAT gene and lipid analysis of the cornea. (9261271)
1997
49
Negative-configuration electroretinogram in Oregon eye disease. Consistent phenotype in Xp21 deletion syndrome. (8240114)
1993
50
Localization of the Aland Island eye disease locus to the pericentromeric region of the X chromosome by linkage analysis. (1985461)
1991

Variations for Eye Disease

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Expression for genes affiliated with Eye Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eye Disease

Search GEO for disease gene expression data for Eye Disease.

Pathways for genes affiliated with Eye Disease

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Sources:
51PathCards, 13EMD Millipore, 61Thomson Reuters, 39NCBI BioSystems Database, 52PharmGKB, 56Reactome, 31KEGG
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Pathways related to Eye Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7APOA1, APOA2
29.7APOA1, APOA2
3
Show member pathways
9.4LCAT, APOA2, APOA1
4
Show member pathways
9.4APOA1, APOA2, LCAT
5
Show member pathways
9.1APOA2, APOA1, GK
6
Show member pathways
fatty acid beta-oxidation VI (peroxisome)39
9.1APOA2, APOA1, GK
7
Show member pathways
8.4LCAT, APOA2, APOA1, GK, OAT

Compounds for genes affiliated with Eye Disease

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB
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Compounds related to Eye Disease according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1pdpc4610.1LCAT, APOA1
2lecithin4610.1LCAT, APOA2
3torcetrapib4610.1APOA1, LCAT
4plpc4610.1APOA1, LCAT
5retinyl palmitate46 2511.1LCAT, APOA1
6probucol46 1211.0LCAT, APOA1
7guanidine46 25 1211.9LCAT, APOA1
8gemfibrozil30 46 1211.9APOA1, APOA2
9mspi469.9APOA2, APOA1
10acetaldehyde30 46 2511.9LCAT, APOA1
11p-opc469.8LCAT, APOA2, APOA1
12dimyristoylphosphatidylcholine469.8APOA1, APOA2, LCAT
13intralipid469.7LCAT, APOA2, APOA1
14cholesterol ester469.7APOA1, APOA2, LCAT
15bezafibrate46 30 1211.7LCAT, APOA2, APOA1
16fenofibrate46 52 1211.7APOA2, APOA1
17phosphatidylcholine469.7APOA1, APOA2, LCAT
18phospholipid469.5APOA1, APOA2, LCAT
19phosphoenolpyruvate46 1210.4OAT, GK
20cholesterol46 30 25 1212.3ROM1, LCAT, APOA2, APOA1
21fatty acid469.2LCAT, APOA2, GK
22glutamine469.2LCAT, APOA2, OAT
23triacylglycerol469.1LCAT, APOA2, APOA1, GK

GO Terms for genes affiliated with Eye Disease

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Sources:
17Gene Ontology
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Cellular components related to Eye Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particleGO:0343619.7APOA2, APOA1
2spherical high-density lipoprotein particleGO:0343669.4APOA2, APOA1
3high-density lipoprotein particleGO:0343649.3LCAT, APOA2, APOA1

Biological processes related to Eye Disease according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein biosynthetic processGO:04215810.1APOA1, LCAT
2negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.0APOA2, APOA1
3negative regulation of lipase activityGO:06019210.0APOA2, APOA1
4regulation of intestinal cholesterol absorptionGO:03030010.0APOA1, APOA2
5high-density lipoprotein particle assemblyGO:03438010.0APOA1, APOA2
6protein oxidationGO:01815810.0APOA1, APOA2
7cholesterol transportGO:03030110.0LCAT, APOA1
8negative regulation of cytokine secretion involved in immune responseGO:00274010.0APOA1, APOA2
9peptidyl-methionine modificationGO:01820610.0APOA2, APOA1
10high-density lipoprotein particle clearanceGO:0343849.9APOA2, APOA1
11positive regulation of cholesterol esterificationGO:0108739.9APOA1, APOA2
12phospholipid effluxGO:0337009.9APOA2, APOA1
13cholesterol effluxGO:0333449.8APOA1, APOA2
14retina development in camera-type eyeGO:0600419.8NPHP1, CACNA1F
15high-density lipoprotein particle remodelingGO:0343759.8APOA1, APOA2, LCAT
16reverse cholesterol transportGO:0436919.8LCAT, APOA2, APOA1
17phosphatidylcholine biosynthetic processGO:0066569.8LCAT, APOA2, APOA1
18lipoprotein metabolic processGO:0421579.8APOA1, APOA2, LCAT
19cholesterol homeostasisGO:0426329.7LCAT, APOA2, APOA1
20cholesterol metabolic processGO:0082039.7LCAT, APOA2, APOA1
21organ regenerationGO:0311009.7APOA1, APOA2
22response to estrogenGO:0436279.7APOA2, APOA1
23triglyceride metabolic processGO:0066419.5APOA2, GK
24retinoid metabolic processGO:0015239.4APOA2, APOA1
25cellular lipid metabolic processGO:0442559.2APOA2, APOA1, GK
26visual perceptionGO:0076018.7ROM1, CACNA1F, RP2, NYX, OAT
27small molecule metabolic processGO:0442818.6LCAT, APOA2, APOA1, GK, OAT

Molecular functions related to Eye Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1apolipoprotein receptor bindingGO:0341909.9APOA2, APOA1
2high-density lipoprotein particle receptor bindingGO:0706539.8APOA2, APOA1
3phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.8APOA2, APOA1
4lipase inhibitor activityGO:0551029.8APOA2, APOA1
5high-density lipoprotein particle bindingGO:0080359.7APOA1, APOA2
6phospholipid bindingGO:0055439.7APOA2, APOA1
7cholesterol transporter activityGO:0171279.6APOA2, APOA1
8cholesterol bindingGO:0154859.4APOA2, APOA1

Products for genes affiliated with Eye Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eye Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet