Aliases & Classifications for Eye Disease

MalaCards integrated aliases for Eye Disease:

Name: Eye Disease 12 14
Disorder of Eye 69
Eye Diseases 42

Classifications:



Summaries for Eye Disease

Disease Ontology : 12 An eye and adnexa disease that is located in the eye.

MalaCards based summary : Eye Disease, also known as disorder of eye, is related to macular degeneration, age-related, 1 and fish-eye disease, and has symptoms including eye manifestations, pain in or around eye and redness or discharge of eye. An important gene associated with Eye Disease is RDH12 (Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis)), and among its related pathways/superpathways are Creation of C4 and C2 activators and Complement and coagulation cascades. The drugs Bimatoprost and Latanoprost have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and thyroid, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 This is a partial list of human eye diseases and... more...

Related Diseases for Eye Disease

Diseases related to Eye Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
id Related Disease Score Top Affiliating Genes
1 macular degeneration, age-related, 1 30.9 ABCA4 ARMS2 C2 C3 CFB CFH
2 fish-eye disease 12.2
3 aland island eye disease 12.2
4 bornholm eye disease 12.0
5 ethylmalonic encephalopathy 11.2
6 norum disease 11.2
7 der kaloustian mcintosh silver syndrome 11.1 C3 CFB CFH
8 rhizomelic chondrodysplasia punctata 11.1 ARMS2 C2 C3 CFB CFH
9 multiple familial trichoepithelioma 11.1 ARMS2 CFB CFH HTRA1 TNF
10 ventricular extrasystoles with syncope, perodactyly, and robin sequence 11.1 ABCA4 CEP290 CFH VEGFA
11 iliac vein thrombophlebitis 11.1 ARMS2 CFB CFH VEGFA
12 endosalpingiosis 11.1 ARMS2 CFB CFH HTRA1 TNF
13 placental choriocarcinoma 11.1 ABCA4 ARMS2 CFB CFH HTRA1 VEGFA
14 hypotrichosis 2 11.1 C2 CFB
15 upper gum cancer 11.1 CEP290 IL1B TNF
16 uterine adnexa cancer 11.1 C3 CFH IL1B TNF
17 bipolar i disorder 11.0 IL1B TNF VEGFA
18 chronic progressive external ophthalmoplegia 11.0 C3 CFB CFH
19 cone-rod dystrophy 3 11.0 ABCA4 CACNA1F
20 early-onset zonular cataract 11.0 IL1B TNF VEGFA
21 prostate carcinoma in situ 11.0 CFH IL1B TNF VEGFA
22 spondylolysis 11.0 IL1B TNF VEGFA
23 tabatznik syndrome 10.9 IL1B TNF
24 optic nerve hypoplasia 10.9 IL1B PAX6 TNF
25 sternal cleft 10.9 IL1B TNF
26 cutaneous leishmaniasis 10.9 TNF VEGFA
27 dolk-congenital disorder of glycosylation 10.9 C3 CFB
28 superior limbic keratoconjunctivitis 10.8
29 pulmonary hypertension 10.8 IL1B TNF
30 walker dyson syndrome 10.8 IL1B TNF
31 cerebellar ataxia, areflexia, pes cavus, optic atrophy and sensorinural hearing loss 10.7 ARMS2 CFH
32 night blindness 10.7
33 familial lcat deficiency 10.7
34 cavitary optic disc anomalies 10.7
35 myopia, x-linked 10.7
36 ocular hypertension 10.6
37 thyroiditis 10.4
38 senior-loken syndrome-1 10.4
39 usher syndrome 10.4
40 retinal disease 10.4
41 corneal dystrophy, schnyder type 10.3
42 senior-loken syndrome 4 10.3
43 macular degeneration, age-related, 2 10.3
44 macular degeneration, age-related, 4 10.3
45 senior-loken syndrome 7 10.3
46 senior-loken syndrome 9 10.3
47 macular degeneration, age-related, 12 10.3
48 usher syndrome, type 3a 10.3
49 senior-loken syndrome 5 10.3
50 glaucoma, normal tension 10.3

Graphical network of the top 20 diseases related to Eye Disease:



Diseases related to Eye Disease

Symptoms & Phenotypes for Eye Disease

UMLS symptoms related to Eye Disease:


eye manifestations, pain in or around eye, redness or discharge of eye, pathological conditions, signs and symptoms, lid retraction, visual disturbance

MGI Mouse Phenotypes related to Eye Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 ABCA4 ABCC6 C3 CEP290 CFH HTRA1
2 homeostasis/metabolism MP:0005376 10.15 IL1B LCAT OAT PAX6 TNF VEGFA
3 nervous system MP:0003631 10.1 CFH IL1B OAT PAX6 RDH12 ROM1
4 renal/urinary system MP:0005367 9.85 ABCC6 C3 CEP290 CFB CFH LCAT
5 pigmentation MP:0001186 9.65 ABCA4 CEP290 CFH OAT PAX6
6 skeleton MP:0005390 9.61 TNF VEGFA ABCA4 C3 CEP290 CFB
7 vision/eye MP:0005391 9.5 TNF VEGFA ABCA4 ABCC6 C3 CACNA1F

Drugs & Therapeutics for Eye Disease

Drugs for Eye Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1071)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bimatoprost Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 155206-00-1 5311027
2
Latanoprost Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130209-82-4 5282380 5311221
3
Timolol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 26839-75-8 33624 5478
4
Travoprost Approved Phase 4,Phase 3,Phase 2,Phase 1 157283-68-6 5282226
5
Propylthiouracil Approved Phase 4,Phase 3,Phase 2 51-52-5 657298
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
8
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
9
Azithromycin Approved Phase 4,Phase 3,Phase 2,Phase 1 83905-01-5 55185 53477736 447043
10
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 564-25-0 54671203
11
Minocycline Approved, Investigational Phase 4,Phase 2,Phase 1 10118-90-8 5281021
12
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 216974-75-3
13
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
14
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757
15
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1 57-63-6 5991
16
Gatifloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112811-59-3 5379
17
Moxifloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 354812-41-2, 151096-09-2 152946
18
Norgestimate Approved Phase 4,Phase 3,Phase 2,Phase 1 35189-28-7 6540478
19
Cyclopentolate Approved Phase 4,Phase 3,Phase 1 512-15-2 2905
20
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
21
Oxymetazoline Approved Phase 4,Phase 3,Phase 2,Phase 1 1491-59-4 4636
22
Phenylephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 59-42-7 6041
23
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
24
Tropicamide Approved Phase 4,Phase 3,Phase 2,Phase 1 1508-75-4 5593
25
Ketorolac Approved Phase 4,Phase 3,Phase 2,Phase 1 74103-06-3, 66635-83-4 3826
26
Dorzolamide Approved Phase 4,Phase 2,Phase 3,Phase 1 120279-96-1 3154 5284549
27
Acetazolamide Approved, Vet_approved Phase 4,Phase 3,Phase 2 59-66-5 1986
28
Dipivefrin Approved Phase 4,Phase 3,Phase 2 52365-63-6 3105
29
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3 51-43-4 5816
30
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
31 Racepinephrine Approved Phase 4,Phase 2,Phase 3
32
Atropine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 5908-99-6, 51-55-8 174174
33
Apraclonidine Approved Phase 4,Phase 3 66711-21-5 2216
34
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 124-94-7 31307
35
Loteprednol Approved Phase 4,Phase 3,Phase 2,Phase 1 82034-46-6, 129260-79-3 444025 9865442
36
Nepafenac Approved Phase 4,Phase 3,Phase 2 78281-72-8 151075
37
Topiramate Approved Phase 4 97240-79-4 5284627
38
Ranibizumab Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 347396-82-1 459903
39
Verteporfin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 129497-78-5
40
Cefazolin Approved Phase 4,Phase 3 25953-19-9 656510 33255
41
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 67-73-2 6215
42
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 9004-61-9 53477741 24759
43
Alcaftadine Approved Phase 4,Phase 3 147084-10-4 19371515
44
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75614-87-8, 51-45-6 774
45
Naphazoline Approved Phase 4,Phase 3 835-31-4 4436
46
Pheniramine Approved Phase 4 86-21-5 4761
47
Ganciclovir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 82410-32-0 3454
48
Fenofibrate Approved Phase 4,Phase 3,Phase 2 49562-28-9 3339
49
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 5460373 44475014
50
Glatiramer Acetate Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 147245-92-9 3081884

Interventional clinical trials:

(show top 50) (show all 7348)

id Name Status NCT ID Phase Drugs
1 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Unknown status NCT01927406 Phase 4 Prostaglandin Analog;Timolol
2 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
3 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
4 Lipids of the Human Tear Film and Their Effect on Tear Stability Unknown status NCT00803452 Phase 4 doxycycline;essential fatty acid;azithromycin
5 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
6 Use of Bevacizumab to Modulate the Outcomes of Trabeculectomy Surgery Unknown status NCT01229202 Phase 4 Bevacizumab
7 Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus Unknown status NCT00797030 Phase 4 cyclosporine and sodium carboximethycellulose;sodium carboximethycellulose
8 Prospective Evaluation of Open-Angle Glaucoma Subjects on One Topical Hypotensive Medication Treated With Two iStents Unknown status NCT01252862 Phase 4
9 Purpose of This Study is to Evaluate the Safety and Efficacy of One, Two, or Three iStents for the Reduction of Intraocular Pressure in Open-angle Glaucoma Subjects Unknown status NCT01252849 Phase 4
10 Prospective Evaluation of Open-angle Glaucoma Subjects on Two Topical Hypotensive Medication Treated With Two iStents Unknown status NCT01252888 Phase 4
11 Effectiveness Study of Zymar Versus Vigamox for Preoperative Sterilization of the Ocular Surface After Loading Dose Unknown status NCT00347828 Phase 4 Moxifloxacin ophthalmic solution 0.5%;Gatifloxacin ophthalmic solution 0.3%
12 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
13 Prospective, Randomized, Controlled Study to Assess Efficacy,Safety, and Tolerability of SLT vs. PLT in Patients With POAG Unknown status NCT02231515 Phase 4
14 A New More Efficient Cycloplegia Scheme Unknown status NCT02177539 Phase 4 Cyclopentolate;Cyclopentolate+tropicamide+phenylephrine
15 The Laser in Pseudoexfoliation (LIP) Study Unknown status NCT01704989 Phase 4 Prostagladin
16 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4 Timolol & Dorzolamide
17 The Effect of "Eye Drop Guide" on the Success Rate of Eye Drops Self-instillation in Glaucoma Patients Unknown status NCT01704248 Phase 4
18 Show Improved Vision With the HOYA AF-1 Aspheric Intraocular Lens After Cataract Surgery Unknown status NCT01382641 Phase 4
19 Effects of Cosopt on IOP and on Ocular Diastolic Perfusion Pressure Unknown status NCT00796198 Phase 4 Xalatan+Cosopt;Xalatan
20 Echothiophate Iodide for the Prevention of Progression of Myopia Unknown status NCT02544529 Phase 4 Echothiophate Iodide 0.03% Ophthalmic Solution;Carboxymethylcellulose Sodium (0.5%)
21 A Intra-patient Comparison of Closed Loop and Plate Haptic Toric Intraocular Lenses Unknown status NCT02264457 Phase 4
22 A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser in Asian Eyes Using LASIK Unknown status NCT01977807 Phase 4
23 Combigan Ophthalmic Solution(Brimonidine 0.2% and Timolol 0.5%)With Latanoprost Compared With Latanoprost Monotherapy Unknown status NCT00442312 Phase 4 Combigan Ophthalmic Solutiom
24 Tear Film Evaluation After Phacoemulsification Unknown status NCT02238015 Phase 4
25 ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function Unknown status NCT00485238 Phase 4 Intravenous acetazolamide
26 Efficacy of Subtenon's Block With Olive Tipped Cannula Unknown status NCT01019018 Phase 4
27 Open-angle Glaucoma Subjects on One Ocular Hypotensive Medication Randomized to Treatment With Two Trabecular Micro-bypass Stents or Selective Laser Trabeculoplasty Unknown status NCT01444105 Phase 4
28 Evaluation of Safety and Efficacy of Glaucoma Shunt (Aurolab Artificial Drainage Implant) in Refractory Glaucoma Unknown status NCT01401088 Phase 4
29 A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser Using LASIK Unknown status NCT02071576 Phase 4
30 Prospective Investigation of SUPRACOR Visual Outcomes of Presbyopic Hyperopic Patients With and Without Astigmatism Unknown status NCT01628146 Phase 4
31 Multi Laser Platform Comparison Study for LASIK Unknown status NCT00770094 Phase 4
32 Subconjunctival Bevacizumab to Prevent Bleb Failure After Glaucoma Filtration Surgery Unknown status NCT00468429 Phase 4 Subconjunctival Bevacizumab
33 AMO's Tecnis™ Multifocal Intraocular Lenses (Tecnis MF), Alcon's ReStor Multifocal IOL Unknown status NCT01278420 Phase 4
34 A Prospective Safety and Effectiveness Study of a New High Repetition Rate Excimer Laser Using LASIK for the Correction of Ammetropia and Presbyopia Unknown status NCT02112968 Phase 4
35 Efficacy and Safety of Three Different Latanoprost 0,005% Eyedrops in Subjects Affected by Primary Open Angle Glaucoma Unknown status NCT01580254 Phase 4 IOPIZE© Latanoprost eyedrops;GALAXIA© Latanoprost eyedrops;Latanoprost RATIOPHARM© latanoprost eyedrops
36 Clinical Investigation of the Bi Flex M Multifocal IOL Unknown status NCT02338882 Phase 4
37 Ologen (OculusGen)-Glaucoma MMC Control Trial in India Unknown status NCT00449098 Phase 4 Trabeculectomy with MMC
38 Clinical Evaluation of Toric Intraocular Lens Made by Aurolab Unknown status NCT01396616 Phase 4
39 The Impact of Topical Prostaglandins on the Biomechanical Properties of the Cornea in Patients With Open Angle Glaucoma Unknown status NCT02388360 Phase 4 topical prostaglandin analogs
40 Aqueous Absorption and Pharmacokinetics of Besivance Versus VIGAMOX in Patients Undergoing Phacoemulsification Unknown status NCT01296191 Phase 4 Moxifloxacin;besifloxacin
41 Saline Injection - Assisted Anesthesia in Eyelid Surgery Unknown status NCT01239498 Phase 4
42 Study of Myopia Prevention in Children With Low Concentration of Atropine Unknown status NCT00541177 Phase 4 atropine;tropicamide
43 Choroidal Thickness in Glaucoma Patients and Healthy Controls Unknown status NCT01293474 Phase 4
44 A Study of the Glaukos Trabecular Micro-bypass Stent in Open Angle Glaucoma Subjects 1 Stent Versus 2 Unknown status NCT00326079 Phase 4
45 Clinical Investigation of the Modified Rayner Monofocal Aspheric 600C (With Axis Marks) Intraocular Lens Unknown status NCT02378636 Phase 4
46 Evaluation of Clinical Outcomes Following Implantation of a Sub-2mm Hydrophilic MICS Intraocular Lens Unknown status NCT01615861 Phase 4
47 A Comparison of Prophylactic Antibacterial Efficacy of Besivance vs. VIGAMOX Prior to Cataract Surgery Unknown status NCT01296542 Phase 4
48 Adjunctive Local Application of Lidocaine During Scleral Buckling Under General Anesthesia Unknown status NCT01417572 Phase 4 lidocaine
49 Pterygium Head Body MMC1: Two Different Surgical Procedures and Their Effect on Endothelial Cell Count. Unknown status NCT02641132 Phase 4 Mitomycin C 0.02%
50 Micropulse Laser Trabeculoplasty Versus Selective Laser Trabeculoplasty for Treatment of Open Angle Glaucoma Unknown status NCT01956942 Phase 4

Search NIH Clinical Center for Eye Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: eye diseases

Genetic Tests for Eye Disease

Anatomical Context for Eye Disease

MalaCards organs/tissues related to Eye Disease:

39
Eye, Endothelial, Thyroid, Testes, Brain, Retina, Bone

Publications for Eye Disease

Articles related to Eye Disease:

(show top 50) (show all 775)
id Title Authors Year
1
Dataset of tear film cytokine levels in dry eye disease (DED) patients with and without HIV infection. ( 27942559 )
2017
2
Rho Kinase in Eye Disease. ( 28928984 )
2017
3
Assessment of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Dry Eye Disease. ( 28910561 )
2017
4
Association between objective signs and subjective symptoms of dry eye disease in patients with systemic sclerosis. ( 28884335 )
2017
5
The potential influence of Schirmer strip variables on dry eye disease characterisation, and on tear collection and analysis. ( 28951004 )
2017
6
Assessment of the Tear Meniscus by Strip Meniscometry and Keratograph in Patients With Dry Eye Disease According to the Presence of Meibomian Gland Dysfunction. ( 28060066 )
2017
7
Conjunctival impression cytology evaluation of patients with dry eye disease using scleral contact lenses. ( 28089075 )
2017
8
A case of concurrent silent sinus syndrome, thyroid eye disease, idiopathic orbital inflammatory syndrome, and dacryoadenitis. ( 28812921 )
2017
9
Lifitegrast for the treatment of dry eye disease in adults. ( 28841079 )
2017
10
Prevalence and Associations of Retinal Emboli With Ethnicity, Stroke, and Renal Disease in a Multiethnic Asian Population: The Singapore Epidemiology of Eye Disease Study. ( 28837736 )
2017
11
Dry eye disease in the elderly in a French population-based study (the Montrachet study: Maculopathy, Optic Nerve, nuTRition, neurovAsCular and HEarT diseases): Prevalence and associated factors. ( 28939118 )
2017
12
Corneal Nerve Regeneration after Self-Retained Cryopreserved Amniotic Membrane in Dry Eye Disease. ( 28894606 )
2017
13
Regarding the influence of sex and aging on dry eye disease. ( 28932110 )
2017
14
Sex differences in the effect of aging on dry eye disease. ( 28860734 )
2017
15
Peripheral Retinal Changes Associated withA Age-Related Macular Degeneration inA the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report Number 12 by theA Age-Related Eye Disease Study 2 Optos PEripheral RetinA (OPERA) Study Research Group. ( 28089680 )
2017
16
Semifluorinated Alkane Eye Drops for Treatment of Dry Eye Disease Due to Meibomian Gland Disease. ( 28922088 )
2017
17
Epidemiology of dry eye disease in Africa: The sparse information, gaps and opportunities. ( 28065724 )
2017
18
Characterizing Intraorbital Optic Nerve Changes on Diffusion Tensor Imaging in Thyroid Eye Disease Before Dysthyroid Optic Neuropathy. ( 28937496 )
2017
19
Dry eye disease and oxidative stress. ( 28834388 )
2017
20
Patients With Dry Eye Disease and Low Subbasal Nerve Density Are at High Risk for Accelerated Corneal Endothelial Cell Loss. ( 28060067 )
2017
21
Protocol for a scoping review to map evidence from randomised controlled trials on paediatric eye disease to disease burden. ( 28821263 )
2017
22
Epidemiology of a Rare Event: The Singapore Epidemiology of Eye Disease Study. ( 28837707 )
2017
23
Resolution of pinguecula-related dry eye disease after argon laser photocoagulation. ( 28769593 )
2017
24
Lifitegrast for the Treatment of Dry Eye Disease: Results of a Phase III, Randomized, Double-Masked, Placebo-Controlled Trial (OPUS-3). ( 28079022 )
2017
25
Lifitegrast Ophthalmic Solution 5%: A Review in Dry Eye Disease. ( 28058622 )
2017
26
A comparative review of Haute AutoritAc de SantAc and National Institute for Health and Care Excellence health technology assessments of IkervisAr to treat severe keratitis in adult patients with dry eye disease which has not improved despite treatment with tear substitutes. ( 28839524 )
2017
27
Surgical outcomes of unilateral recession-resection for vertical strabismus in patients with thyroid eye disease. ( 28089937 )
2017
28
Radiotherapy for the treatment of thyroid eye disease-a prospective comparison: Is orbital radiotherapy a suitable alternative to steroids? ( 28050807 )
2017
29
Human T Cell Leukemia Virus Type 1 and Eye Diseases. ( 28263674 )
2017
30
Drugs - Do we need them? Applications of non-pharmaceutical therapy in anterior eye disease: A review. ( 28919243 )
2017
31
Can the optimum artificial tear treatment for dry eye disease be predicted from presenting signs and symptoms? ( 28811095 )
2017
32
In Vivo Confocal Microscopy Evaluation of Ocular Surface with Graft-Versus-Host Disease-Related Dry Eye Disease. ( 28878217 )
2017
33
Prospective Study of Eye Disease in Timor-Leste: The East Timor Eye Program. ( 27213765 )
2016
34
Comprehensive Review of the Literature on Existing Punctal Plugs for the Management of Dry Eye Disease. ( 27088009 )
2016
35
Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes. ( 27173377 )
2016
36
Discordant Dry Eye Disease (An American Ophthalmological Society Thesis). ( 28050051 )
2016
37
Repeatability and Reproducibility of Noninvasive Keratograph 5M Measurements in Patients with Dry Eye Disease. ( 27190639 )
2016
38
PARS PLANA VITRECTOMY IN ADVANCED CASES OF VON HIPPEL-LINDAU EYE DISEASE. ( 26308528 )
2016
39
Predictors of Discordance between Symptoms and Signs in Dry Eye Disease. ( 28024826 )
2016
40
Structural Functional Associations of the Orbit in Thyroid Eye Disease: Kalman Filters to Track Extraocular Rectal Muscles. ( 27127330 )
2016
41
NRP1 function and targeting in neurovascular development and eye disease. ( 26923176 )
2016
42
Prevalence of Childhood Blindness and Ocular Morbidity in a Rural Pediatric Population in Southern India: The Pavagada Pediatric Eye Disease Study-1. ( 27142419 )
2016
43
Corneal permeability changes in dry eye disease: an observational study. ( 27177442 )
2016
44
Safety of Lifitegrast Ophthalmic Solution 5.0% in Patients With Dry Eye Disease: A 1-Year, Multicenter, Randomized, Placebo-Controlled Study. ( 27055211 )
2016
45
The eye disease of Jean-Paul Sartre and its impact on his literary work. ( 27091424 )
2016
46
Efficacy of a fixed combination of 0.09A % xanthan gum/0.1A % chondroitin sulfate preservative free vs polyethylene glycol/propylene glycol in subjects with dry eye disease: a multicenter randomized controlled trial. ( 27645318 )
2016
47
Dry Eye Disease in Patients with Functioning Filtering Blebs after Trabeculectomy. ( 27032098 )
2016
48
Fish-eye disease: Another under-recognized cause of familial corneal opacification. ( 26854387 )
2016
49
Hot topics in dry eye disease. ( 27928967 )
2016
50
Tear Interferon-Gamma as a Biomarker for Evaporative Dry Eye Disease. ( 27654409 )
2016

Variations for Eye Disease

ClinVar genetic disease variations for Eye Disease:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 RDH12 NM_152443.2(RDH12): c.806_810delCCCTG (p.Ala269Glyfs) deletion Pathogenic rs386834261 GRCh37 Chromosome 14, 68196055: 68196059
2 ABCC6 NM_001171.5(ABCC6): c.3389C> T (p.Thr1130Met) single nucleotide variant Pathogenic/Likely pathogenic rs63750459 GRCh37 Chromosome 16, 16256967: 16256967
3 VPS13B NM_017890.4(VPS13B): c.2591C> A (p.Ser864Ter) single nucleotide variant Pathogenic/Likely pathogenic rs140936527 GRCh37 Chromosome 8, 100286501: 100286501
4 CNGA3 NM_001298.2(CNGA3): c.1688G> A (p.Arg563His) single nucleotide variant Pathogenic/Likely pathogenic rs552069173 GRCh37 Chromosome 2, 99013321: 99013321
5 CNGB3 NM_019098.4(CNGB3): c.1285delT (p.Ser429Leufs) deletion Pathogenic/Likely pathogenic GRCh37 Chromosome 8, 87645015: 87645015
6 ABCC6 NM_001171.5(ABCC6): c.4104delC (p.Asp1368Glufs) deletion Pathogenic rs72664237 GRCh38 Chromosome 16, 16154732: 16154732
7 IMPG2 NM_016247.3(IMPG2): c.1680T> A (p.Tyr560Ter) single nucleotide variant Pathogenic rs758291149 GRCh37 Chromosome 3, 100963495: 100963495

Expression for Eye Disease

Search GEO for disease gene expression data for Eye Disease.

Pathways for Eye Disease

Pathways related to Eye Disease according to GeneCards Suite gene sharing:

(show all 11)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.83 C2 C3 CFB CFH
2 11.77 C2 C3 CFB CFH
3
Show member pathways
11.68 C2 C3 CFB CFH
4 11.65 IL1B TNF VEGFA
5 11.59 IL1B TNF VEGFA
6
Show member pathways
11.48 C2 C3 CFB CFH
7
Show member pathways
11.41 IL1B TNF VEGFA
8 11.32 C3 IL1B TNF
9 11.14 C2 C3 IL1B TNF
10 10.7 IL1B TNF
11 10.67 C2 C3 CFB CFH

GO Terms for Eye Disease

Cellular components related to Eye Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 C2 C3 CEP290 CFB CFH HTRA1
2 extracellular space GO:0005615 9.28 C2 C3 CFB CFH HTRA1 IL1B

Biological processes related to Eye Disease according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.78 C3 IL1B TNF VEGFA
2 regulation of complement activation GO:0030449 9.67 C2 C3 CFB CFH
3 negative regulation of lipid catabolic process GO:0050995 9.58 IL1B TNF
4 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.57 IL1B TNF
5 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.56 IL1B VEGFA
6 complement activation GO:0006956 9.56 C2 C3 CFB CFH
7 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.55 IL1B TNF
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 IL1B TNF
9 positive regulation of chemokine biosynthetic process GO:0045080 9.52 IL1B TNF
10 regulation of establishment of endothelial barrier GO:1903140 9.51 IL1B TNF
11 positive regulation of phagocytosis GO:0050766 9.5 C3 IL1B TNF
12 positive regulation of apoptotic cell clearance GO:2000427 9.49 C2 C3
13 positive regulation of fever generation GO:0031622 9.46 IL1B TNF
14 sequestering of triglyceride GO:0030730 9.43 IL1B TNF
15 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IL1B TNF
16 eye photoreceptor cell development GO:0042462 9.33 CEP290 PAX6 VEGFA
17 visual perception GO:0007601 9.23 ABCA4 ABCC6 CACNA1F IMPG2 OAT PAX6
18 complement activation, alternative pathway GO:0006957 9.13 C3 CFB CFH

Molecular functions related to Eye Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.92 C2 C3 CFB HTRA1

Sources for Eye Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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