MCID: EYL001
MIFTS: 27

Eyelid Neoplasm

Categories: Cancer diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Eyelid Neoplasm

MalaCards integrated aliases for Eyelid Neoplasm:

Name: Eyelid Neoplasm 12 14
Eyelid Carcinoma 12 14 69
Eyelid Neoplasms 42 69
Carcinoma of the Eyelid 12
Tumor of the Eyelid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2173 DOID:6425
MeSH 42 D005142
NCIt 47 C3031 C6078
SNOMED-CT 64 278697001

Summaries for Eyelid Neoplasm

MalaCards based summary : Eyelid Neoplasm, also known as eyelid carcinoma, is related to iritis and rete ovarii adenocarcinoma. An important gene associated with Eyelid Neoplasm is FEZF1 (FEZ Family Zinc Finger 1). The drugs Bacitracin and Erythromycin have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and lymph node, and related phenotype is cellular.

Related Diseases for Eyelid Neoplasm

Diseases related to Eyelid Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
id Related Disease Score Top Affiliating Genes
1 iritis 10.4 FEZF1 FEZF2
2 rete ovarii adenocarcinoma 10.4 FEZF1 FEZF2
3 substance dependence 10.4 FEZF1 FEZF2
4 angiomyolipoma 10.3 FEZF1 FEZF2
5 lacrimal gland mucoepidermoid carcinoma 10.2 FEZF1 FEZF2
6 brain angioma 10.2 KITLG MUC2
7 basal cell carcinoma 10.1
8 breast mucinous cystadenocarcinoma 10.1 KRT20 MUC2
9 testicular trophoblastic tumor 10.1 KRT20 MUC2
10 tabes dorsalis 10.1 KRT20 MUC2
11 merkel cell carcinoma 10.1
12 stricture or kinking of ureter 10.1 KRT20 MUC2
13 anemia of prematurity 10.1 KRT20 MUC2
14 ovarian mucinous adenocarcinoma 10.1 KRT20 MUC2
15 uterine corpus adenofibroma 10.1 KRT20 MUC2
16 migraine with aura 10.1 KRT20 MUC2
17 childhood ovarian endodermal sinus tumor 10.1 KRT20 MUC2
18 cavernous sinus thrombosis 10.0 KRT20 MUC2
19 prostate small cell carcinoma 10.0 KRT20 MUC2
20 pacinian tumor 10.0 KRT20 MUC2
21 uterine corpus apoplectic leiomyoma 10.0 KRT20 MUC2
22 pancreatic signet ring cell adenocarcinoma 10.0 KRT20 MUC2
23 breast mucinous carcinoma 10.0 KRT20 MUC2
24 optic papillitis 10.0 KRT20 MUC2
25 microcystic meningioma 10.0 KRT20 MUC2
26 striated muscle rhabdoid tumor 10.0 KRT20 MUC2
27 cecum adenocarcinoma 9.9 KRT20 MUC2
28 adenoiditis 9.9
29 choriocarcinoma 9.9 KRT20 MUC2
30 struma ovarii 9.9 KRT20 MUC2
31 urethra adenocarcinoma 9.9 KRT20 MUC2
32 ectodermal dysplasia with natal teeth, turnpenny type 9.8 KRT20 MUC2
33 arteritic anterior ischemic optic neuropathy 9.8 KRT20 MUC2
34 farber lipogranulomatosis 9.7 KRT20 MUC2
35 gastric cancer, somatic 9.7 KRT20 MUC2
36 apocrine adenocarcinoma 9.6 KRT20 MUC2
37 papilloma 9.6
38 verrucous carcinoma 9.6
39 muir-torre syndrome 9.6
40 granular cell tumor 9.6
41 pleomorphic adenoma 9.5
42 lymphoma 9.5
43 melanoma 9.5
44 brown-vialetto-van laere syndrome 9.4 KRT20 MUC2
45 ascending colon cancer 7.9 BAG3 FEZF1 FEZF2 KITLG KRT20 MUC2

Graphical network of the top 20 diseases related to Eyelid Neoplasm:



Diseases related to Eyelid Neoplasm

Symptoms & Phenotypes for Eyelid Neoplasm

MGI Mouse Phenotypes related to Eyelid Neoplasm:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.02 BAG3 FEZF1 FEZF2 KITLG MUC2

Drugs & Therapeutics for Eyelid Neoplasm

Drugs for Eyelid Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 439542 10909430
2
Erythromycin Approved, Vet_approved Phase 4 114-07-8 12560
3 Pharmaceutical Solutions Phase 4,Phase 3
4 Anti-Bacterial Agents Phase 4
5 Antibiotics, Antitubercular Phase 4
6 Anti-Infective Agents Phase 4
7 Anti-Infective Agents, Local Phase 4
8 Antitubercular Agents Phase 4
9 Erythromycin Estolate Phase 4
10 Erythromycin Ethylsuccinate Phase 4
11 Erythromycin stearate Phase 4
12 Gastrointestinal Agents Phase 4
13 Lubricant Eye Drops Phase 4
14 Ophthalmic Solutions Phase 4
15 Tetrahydrozoline Phase 4
16
Bimatoprost Approved, Investigational Phase 3 155206-00-1 5311027
17 Antihypertensive Agents Phase 3
18
Acetylcholine Approved Phase 2 51-84-3 187
19
Fluorouracil Approved Phase 2 51-21-8 3385
20
Carmustine Approved Phase 1, Phase 2 154-93-8 2578
21 abobotulinumtoxinA Phase 2
22 Botulinum Toxins Phase 2
23 Botulinum Toxins, Type A Phase 2
24 Cholinergic Agents Phase 2
25 Neuromuscular Agents Phase 2
26 Neurotransmitter Agents Phase 2
27 onabotulinumtoxinA Phase 2
28 Peripheral Nervous System Agents Phase 2
29 Anesthetics Phase 2
30 Radiopharmaceuticals Phase 2
31 Technetium Tc 99m Sulfur Colloid Phase 2
32 Antimetabolites Phase 2
33 Antimetabolites, Antineoplastic Phase 2
34 Immunosuppressive Agents Phase 2
35 Alkylating Agents Phase 1, Phase 2
36 O(6)-benzylguanine Phase 1, Phase 2
37 Antibodies
38 Immunoglobulins

Interventional clinical trials:

(show all 14)

id Name Status NCT ID Phase Drugs
1 Topical Antibiotic Prophylaxis for Eyelids Recruiting NCT03199911 Phase 4 Topical Anti-Infective Product;Topical Ointment
2 PMCF-study Using Novosyn® Quick Suture Material in Ophthalmic Surgery Withdrawn NCT02761083 Phase 4
3 Periocular Basal Cell Carcinoma (BCC): Permanent vs. Frozen Section Pathological Control Unknown status NCT00663650 Phase 3
4 Study of Bimatoprost Gel on Eyelash Growth Completed NCT01200251 Phase 3 Bimatoprost eyelash gel
5 Determination of the Optimum Delivery Route for Botulinum Toxin A in Patients With Epiphora Completed NCT01282541 Phase 2 Botulinum Toxin Type A;Botulinum Toxin Type A
6 Sentinel Lymph Node (SLN) Biopsy for Sebaceous Gland Carcinoma of Eyelid Recruiting NCT00832429 Phase 2
7 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts Recruiting NCT02705352 Phase 2 5-Fluorouracil
8 O6-Benzylguanine and Topical Carmustine in Treating Patients With Early-Stage IA-IIA Cutaneous T-Cell Lymphoma Active, not recruiting NCT00961220 Phase 1, Phase 2 Carmustine;O6-Benzylguanine
9 Sentinel Lymph Node (SLN) Biopsy for Conjunctival/Eyelid Melanoma Active, not recruiting NCT00386906 Phase 1
10 External Lid Loading for the Temporary Treatment of the Paresis of the M. Orbicularis Oculi: a Clinical Note Completed NCT01274689
11 Helicobacter Pylori and Dry Eye Completed NCT00083291
12 Helical Irradiation of Total Skin (HITS) for Cutaneous Lymphoma Active, not recruiting NCT02039895
13 Tegaderm and Visual Evoked Potentials Terminated NCT02105337
14 Bimatoprost Ophthalmic Solution in Increasing Eyebrow and Eyelash Growth in Patients Who Have Undergone Chemotherapy for Breast Cancer and in Healthy Participants Withdrawn NCT00999557 bimatoprost ophthalmic solution;placebo

Search NIH Clinical Center for Eyelid Neoplasm

Cochrane evidence based reviews: eyelid neoplasms

Genetic Tests for Eyelid Neoplasm

Anatomical Context for Eyelid Neoplasm

MalaCards organs/tissues related to Eyelid Neoplasm:

39
Eye, Skin, Lymph Node, Breast, T Cells

Publications for Eyelid Neoplasm

Articles related to Eyelid Neoplasm:

id Title Authors Year
1
The expression of P53 protein and infection of human papilloma virus in conjunctival and eyelid neoplasms. ( 16142387 )
2005
2
"Pseudo-pseudochalazion": giant chalazion mimicking eyelid neoplasm. ( 16234710 )
2005

Variations for Eyelid Neoplasm

Expression for Eyelid Neoplasm

Search GEO for disease gene expression data for Eyelid Neoplasm.

Pathways for Eyelid Neoplasm

GO Terms for Eyelid Neoplasm

Biological processes related to Eyelid Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 8.62 BAG3 KITLG

Sources for Eyelid Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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