Facial Paralysis malady

Wikipedia: Facial nerve paralysis is a common problem that involves the paralysis of any structures innervated by...⁴⁴ more...

MalaCards: Facial Paralysis, also known as facial palsy (disorder), is related to camurati-engelmann disease and craniodiaphyseal dysplasia. An important gene associated with Facial Paralysis is RNF112 (ring finger protein 112). The drugs scopolamine and scopolamine hydrobromide and the compound digitonin have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and craniofacial.

Aliases & Descriptions:

facial paralysis 6 8 43 facial palsy (disorder) 6

facial palsy 6

Diseases related to facial paralysis by text searches and GeneDecks gene sharing:

(show all 28)

id	Related Disease	Score	Top Affiliating Genes
1	camurati-engelmann disease	28.3	TGFB1, LRP5
2	craniodiaphyseal dysplasia	12.9	TGFB1, LRP5
3	sost-related sclerosing bone dysplasia	12.9	TGFB1, LRP5
4	lattice corneal dystrophy	12.8	GSN, TGFB1
5	acoustic neuroma	12.6	TGFB1, NF2, FKBP4
6	penis non-invasive verrucous carcinoma	12.5	TP63, FKBP4
7	neurofibromatosis	12.4	CADM1, NF2
8	androgenetic alopecia	12.0	TP63, TGFB1
9	cervical squamous cell carcinoma	12.0	CD82, TP63, TGFB1
10	bladder carcinoma	11.7	TGFB1, TP63, GSN, CD82
11	rectal cloacogenic carcinoma	11.7	CD82, GSN, TP63, TGFB1
12	pancreatic ductal carcinoma	11.6	TGFB1, TP63, GSN, CD82
13	cervical intraepithelial neoplasia	11.5	CADM1, TP63, TGFB1
14	ductal carcinoma in situ	11.5	TGFB1, TP63, GSN
15	paralysis	10.3	PODXL2, PRF1, ST18, TGFB1, RNF112, TP63
16	prostatitis	9.0	PRF1, ST18, TGFB1, NF2, TP63, CADM1
17	bell's palsy	8.1
18	melkersson-rosenthal syndrome	7.4
19	ochoa syndrome	7.0
20	recurrent peripheral facial palsy	7.0
21	deafness conductive stapedial ear malformation facial palsy	7.0
22	moebius syndrome	6.9
23	amyloidosis	6.1
24	hereditary congenital facial paresis	6.1
25	hearing loss	6.1
26	sensorineural hearing loss	6.1
27	anotia facial palsy cardiac defect	6.0
28	geniculate herpes zoster	6.0

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 hyoscine hydrobromide, scopolamine, scopolamine hydrobromide

MGI Mouse Phenotypes related to facial paralysis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	7.4	TGFB1, NF2, SP6, TP63, HOXB1, ANKH
2	craniofacial phenotype	MP:0005382	7.4	TGFB1, NF2, SP6, TP63, HOXB1, ANKH
3	hematopoietic system phenotype	MP:0005397	7.2	TGFB1, HOXB1, CADM1, ANKH, GSX1, GSN
4	skeleton phenotype	MP:0005390	7.2	NF2, TP63, HOXB1, ANKH, GSX1, GSN
5	reproductive system phenotype	MP:0005389	6.6	PRF1, TGFB1, NF2, TP63, CADM1, ANKH
6	growth/size phenotype	MP:0005378	6.3	TGFB1, NF2, SP6, TP63, HOXB1, CADM1
7	immune system phenotype	MP:0005387	6.1	PRF1, TGFB1, NF2, TP63, HOXB1, CADM1
8	endocrine/exocrine gland phenotype	MP:0005379	6.1	LRP5, PRF1, TGFB1, NF2, SP6, TP63
9	mortality/aging	MP:0010768	6.0	SP6, NF2, TGFB1, PRF1, TP63, HOXB1

Genes related to facial paralysis according to GeneCards:

(show all 18)

id	Symbol	Description	Score	GeneCards Section Context
1	RNF112	ring finger protein 112	11.0
2	GSX1	GS homeobox 1	11.0	Disorders
3	SP6	Sp6 transcription factor	11.0	Disorders
4	HOXB1	homeobox B1	11.0	Disorders
5	PODXL2	podocalyxin-like 2	11.0
6	CCDC37	coiled-coil domain containing 37	11.0
7	FKBP4	FK506 binding protein 4, 59kDa	11.0
8	CD82	CD82 molecule	11.0
9	PRF1	perforin 1 (pore forming protein)	11.0
10	TMCC1	transmembrane and coiled-coil domain family 1	11.0	Disorders
11	ST18	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	11.0
12	ANKH	ankylosis, progressive homolog (mouse)	11.0
13	NF2	neurofibromin 2 (merlin)	11.0
14	LRP5	low density lipoprotein receptor-related protein 5	11.0
15	GSN	gelsolin	11.0
16	CADM1	cell adhesion molecule 1	11.0
17	TP63	tumor protein p63	11.0
18	TGFB1	transforming growth factor, beta 1	11.0

Compounds related to facial paralysis according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	digitonin32	9.7	CD82, GSN

Biological processes related to facial paralysis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	lens fiber cell differentiation	GO:070306	9.5	NF2, TGFB1
2	negative regulation of DNA replication	GO:008156	9.5	NF2, TGFB1
3	negative regulation of cell-cell adhesion	GO:022408	9.4	NF2, TGFB1
4	cell-cell junction organization	GO:045216	9.0	CADM1, NF2, TGFB1
5	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.9	TGFB1, TP63, HOXB1, GSX1, LRP5