MCID: FCL012
MIFTS: 49

Facial Paralysis malady

Summaries for Facial Paralysis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Facial nerve paralysis is a common problem that involves the paralysis of any structures innervated by... more...

MalaCards: Facial Paralysis, also known as facial palsy, is related to acoustic neuroma and sost-related sclerosing bone dysplasia. An important gene associated with Facial Paralysis is HOXB1 (homeobox B1). The drugs scopolamine and scopolamine hydrobromide and the compounds cytochalasin d and digitonin have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and skin, and related mouse phenotypes are respiratory system and skeleton.

Aliases & Classifications for Facial Paralysis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

facial paralysis 8 10 60
facial palsy 8


External Ids:

Disease Ontology8 DOID:13934
MeSH34 D005158
NCIt39 C26769

Related Diseases for Facial Paralysis

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17GeneCards, 18GeneDecks
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Diseases related to Facial Paralysis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1acoustic neuroma30.3FKBP4
2sost-related sclerosing bone dysplasia30.1LRP5, TGFB1
3neurofibromatosis30.1CADM1, NF2
4camurati-engelmann disease29.9TGFB1, LRP5
5breast cancer29.9TP63, NF2, FKBP4, GSN, TGFB1
6squamous cell carcinoma29.9GSN, CADM1, TP63, TGFB1, CD82
7bell's palsy10.7
8otitis media10.5
9bone fracture10.4
10ectropion10.3
11wegener's granulomatosis10.3
12parotitis10.3
13herpes simplex10.3
14melkersson-rosenthal syndrome10.3
15cholesteatoma10.3
16hypertension10.3
17neuroma10.3
18familial recurrent peripheral facial palsy10.2
19deafness - ear malformation - facial palsy10.2
20meningitis10.2
21hereditary congenital facial paresis 310.2
22isolated hereditary congenital facial paralysis10.2
23tolosa-hunt syndrome10.2
24anotia facial palsy cardiac defect10.2
25deafness conductive stapedial ear malformation facial palsy10.2
26recurrent peripheral facial palsy10.2
27middle ear adenoma10.1
28petrositis10.1
29adenoma10.1
30amyloidosis10.1
31glomus tumor10.1
32lagophthalmos10.1
33neuritis10.1
34neuroblastoma10.1
35skull base neoplasm10.1
36suppurative otitis media10.1
37tuberculosis10.1
38moebius syndrome10.1
39familial amyloidosis, finnish type10.1
40cat-scratch disease10.1
41cerebritis10.1
42leptospirosis10.1
43urofacial syndrome10.1
44cutaneous anthrax10.1
45chickenpox10.1
46adult syndrome10.1
47craniometaphyseal dysplasia10.1
48mumps10.1
49cerebral palsy10.1
50encephalitis10.1

Graphical network of the top 20 diseases related to Facial Paralysis:



Diseases related to facial paralysis

Clinical Features for Facial Paralysis

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Drugs & Therapeutics for Facial Paralysis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Facial Paralysis

Drug clinical trials:

Search ClinicalTrials for Facial Paralysis

Search NIH Clinical Center for Facial Paralysis

Search CenterWatch for Facial Paralysis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Facial Paralysis

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Anatomical Context for Facial Paralysis

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32MalaCards
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MalaCards organs/tissues related to Facial Paralysis:

32
Bone, Eye, Skin, Testes, Heart, Breast, Liver, Cortex, Brain, Tongue

Animal Models for Facial Paralysis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Facial Paralysis:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7ANKH, NF2, HOXB1, SP6, TP63, GSN
2MP:00053908.6CADM1, ANKH, NF2, HOXB1, LRP5, TP63
3MP:00053828.5ANKH, NF2, HOXB1, LRP5, SP6, TP63
4MP:00053978.3CADM1, PRF1, ANKH, HOXB1, LRP5, GSX1
5MP:00107718.3PRF1, NF2, FKBP4, HOXB1, SP6, TP63
6MP:00053898.2CADM1, PRF1, ANKH, NF2, FKBP4, TP63
7MP:00053868.1PRF1, ANKH, NF2, HOXB1, LRP5, TP63
8MP:00053878.1NF2, ANKH, PRF1, CADM1, HOXB1, LRP5
9MP:00053767.8PRF1, ANKH, NF2, FKBP4, LRP5, TP63
10MP:00053797.7TGFB1, CADM1, PRF1, NF2, FKBP4, HOXB1
11MP:00053787.6CADM1, PRF1, ANKH, NF2, FKBP4, HOXB1
12MP:00107687.4PRF1, ANKH, NF2, FKBP4, HOXB1, LRP5

Publications for Facial Paralysis

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50PubMed
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Articles related to Facial Paralysis:

(show top 50)    (show all 561)
idTitleAuthorsYear
1
Recycle of temporal muscle in combination with free muscle transfer in the treatment of facial paralysis. (23283482)
2013
2
Facial Disfigurement: Restoration of Facial Dynamics in a Patient with Concomitant Facial Paralysis and Blindness. (24114708)
2013
3
Clinical spectrum of peripheral facial paralysis in HIV-infected patients according to HIV status. (23467294)
2013
4
Smile Restoration for Permanent Facial Paralysis. (24086823)
2013
5
Unusual clinical presentation of ethylene glycol poisoning: unilateral facial nerve paralysis. (24307904)
2013
6
Functional training in the management of chronic facial paralysis. (22194280)
2012
7
Measuring quality of life and patient satisfaction in facial paralysis patients: a systematic review of patient-reported outcome measures. (22743876)
2012
8
Double innervation in free-flap surgery for long-standing facial paralysis. (22728067)
2012
9
Therapeutic strategies in post-facial paralysis synkinesis in pediatric patients. (22483723)
2012
10
Utility outcome scores for unilateral facial paralysis. (22964665)
2012
11
Comparison of hemihypoglossal-facial nerve transposition with a cross-facial nerve graft and muscle transplant for the rehabilitation of facial paralysis using the facial clima method. (22455573)
2012
12
Mastoiditis and facial paralysis as initial manifestations of Wegener's Granulomatosis. (22499374)
2012
13
Surgical site infections after gracilis free flap reconstruction for facial paralysis. (22496103)
2012
14
Developmental facial paralysis: a review. (21724478)
2011
15
Facial paralysis: Rhazes' deviation. (21994977)
2011
16
Extrapulmonary small cell carcinoma metastasis to the external auditory canal with facial nerve paralysis. (20447727)
2011
17
Activation of the masseter muscle during normal smile production and the implications for dynamic reanimation surgery for facial paralysis. (21798833)
2011
18
Progressive facial paralysis secondary to a rare temporal bone tumor: glomus faciale. (21768419)
2011
19
Management and outcomes of facial paralysis from intratemporal blunt trauma: a systematic review. (21225812)
2010
20
Recent progress in facial paralysis: advances and obstacles. (20625294)
2010
21
Comprehensive facial rehabilitation improves function in people with facial paralysis: a 5-year experience at the Massachusetts Eye and Ear Infirmary. (20093325)
2010
22
The outcomes of dynamic procedures for blink restoration in pediatric facial paralysis. (20124848)
2010
23
Acute facial paralysis due to primary squamous cell carcinoma of the parotid gland. (17955716)
2007
24
Characteristics and prognosis of malignant external otitis with facial paralysis. (17938323)
2007
25
Ectopic bone formation following temporalis muscle transposition for facial paralysis: a rare complication? (16186726)
2005
26
When is facial paralysis Bell palsy? Current diagnosis and treatment. (15929453)
2005
27
The conjoint medial circumflex femoral perforator and gracilis muscle free flap: anatomical study and clinical use for complex facial paralysis reconstruction. (16267417)
2005
28
Revisional operations improve results of neurovascular free muscle transfer for treatment of facial paralysis. (16079658)
2005
29
Pathologic quiz case: a woman with right facial nerve paralysis. Endolymphatic sac tumor associated with von Hippel-Lindau disease. (14521446)
2003
30
Contralateral reinnervation of midline muscles in facial paralysis. (11745982)
2001
31
Aciclovir for Bell's palsy (idiopathic facial paralysis). (11687127)
2001
32
Facial paralysis: An unusual presentation of congenital cholesteatoma. (10740193)
2000
33
Early perioperative use of polytef suspension for the management of facial paralysis after extirpative skull base surgery. (11074717)
2000
34
Effects of facial paralysis and audiovisual information on stop place identification. (10668659)
2000
35
Temporalis muscle transfer for facial paralysis: a further refinement. (11460301)
2000
36
Intratemporal facial paralysis: its bases and clinical applications. Commemoration issue of the retirement of professor Haruo Saito from the Department of Otolaryngology, Kochi Medical School. (17378099)
2000
37
Surgical management of the facial nerve in craniofacial trauma and long-standing facial paralysis: cadaver study and clinical presentations. (11951222)
1999
38
Delayed facial paralysis after stapedotomy using KTP laser. (10431880)
1999
39
Facial reanimation with jump interpositional graft hypoglossal facial anastomosis and hypoglossal facial anastomosis: evolution in management of facial paralysis. (10884169)
1999
40
Evaluating facial paralysis. Expensive diagnostic tests are often unnecessary. (9633550)
1998
41
Neurovascular free muscle transfer combined with cross-face nerve grafting for the treatment of facial paralysis in children. (9623816)
1998
42
Cat scratch disease presenting with peripheral facial nerve paralysis. (9565446)
1998
43
Analysis of 100 cases of free-muscle transplantation for facial paralysis. (9180714)
1997
44
Quantitative assessment of the variation within grades of facial paralysis. (8614218)
1996
45
Paralysis of facial muscles in leprosy patients with lagophthalmos. (8046261)
1994
46
The quantification of synkinesis and facial paralysis. (10774343)
1994
47
Recovery from facial paralysis following crush injury of the facial nerve in hamsters: differential effects of gender and androgen exposure. (8495708)
1993
48
Management of slowly progressive facial paralysis attributable to a tumor in the temporal bone. (1443088)
1992
49
Facial paralysis in acute parotitis. (3687235)
1987
50
Congenital paralysis of sixth and seventh nerves: congenital facial diplegia, congenital oculofacial palsy, MAPbius syndrome. (13292498)
1956

Genetic Variations for Facial Paralysis

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Expression for genes affiliated with Facial Paralysis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Facial Paralysis

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Pathways for genes affiliated with Facial Paralysis

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Compounds for genes affiliated with Facial Paralysis

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44Novoseek, 59Tocris Bioscience
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Compounds related to Facial Paralysis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cytochalasin d44 5910.7TGFB1, GSN, NF2
2digitonin449.3GSN, CD82
3paraffin449.0TGFB1, TP63, CD82, NF2

GO Terms for genes affiliated with Facial Paralysis

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16Gene Ontology
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Biological processes related to Facial Paralysis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lens fiber cell differentiationGO:07030610.0TGFB1, NF2
2negative regulation of DNA replicationGO:00815610.0TGFB1, NF2
3negative regulation of cell-cell adhesionGO:0224089.9TGFB1, NF2
4cell-cell junction organizationGO:0452169.8TGFB1, NF2, CADM1
5positive regulation of transcription from RNA polymerase II promoterGO:0459448.8HOXB1, LRP5, TP63, GSX1, TGFB1

Products for genes affiliated with Facial Paralysis

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  • Antibodies
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  • Antibodies

Sources for Facial Paralysis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet