MCID: FCL012
MIFTS: 49

Facial Paralysis malady

Summaries for Facial Paralysis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Facial nerve paralysis is a common problem that involves the paralysis of any structures innervated by... more...

MalaCards: Facial Paralysis, also known as facial palsy, is related to acoustic neuroma and sost-related sclerosing bone dysplasia. An important gene associated with Facial Paralysis is HOXB1 (homeobox B1). The drugs scopolamine and scopolamine hydrobromide and the compounds cytochalasin d and digitonin have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and skin, and related mouse phenotypes are respiratory system and skeleton.

Aliases & Classifications for Facial Paralysis

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

facial paralysis 8 10 60
facial palsy 8


External Ids:

Disease Ontology8 DOID:13934
MeSH34 D005158
NCIt39 C26769

Related Diseases for Facial Paralysis

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17GeneCards, 18GeneDecks
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Diseases related to Facial Paralysis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1acoustic neuroma30.3FKBP4
2sost-related sclerosing bone dysplasia30.1LRP5, TGFB1
3neurofibromatosis30.1CADM1, NF2
4camurati-engelmann disease29.9TGFB1, LRP5
5breast cancer29.9TP63, NF2, FKBP4, GSN, TGFB1
6squamous cell carcinoma29.9GSN, CADM1, TP63, TGFB1, CD82
7bell's palsy10.7
8otitis media10.5
9bone fracture10.4
10ectropion10.3
11wegener's granulomatosis10.3
12parotitis10.3
13herpes simplex10.3
14melkersson-rosenthal syndrome10.3
15cholesteatoma10.3
16hypertension10.3
17neuroma10.3
18familial recurrent peripheral facial palsy10.2
19deafness - ear malformation - facial palsy10.2
20meningitis10.2
21hereditary congenital facial paresis 310.2
22isolated hereditary congenital facial paralysis10.2
23tolosa-hunt syndrome10.2
24anotia facial palsy cardiac defect10.2
25deafness conductive stapedial ear malformation facial palsy10.2
26recurrent peripheral facial palsy10.2
27middle ear adenoma10.1
28petrositis10.1
29adenoma10.1
30amyloidosis10.1
31glomus tumor10.1
32lagophthalmos10.1
33neuritis10.1
34neuroblastoma10.1
35skull base neoplasm10.1
36suppurative otitis media10.1
37tuberculosis10.1
38moebius syndrome10.1
39familial amyloidosis, finnish type10.1
40cat-scratch disease10.1
41cerebritis10.1
42leptospirosis10.1
43urofacial syndrome10.1
44cutaneous anthrax10.1
45chickenpox10.1
46adult syndrome10.1
47craniometaphyseal dysplasia10.1
48mumps10.1
49cerebral palsy10.1
50encephalitis10.1

Graphical network of the top 20 diseases related to Facial Paralysis:



Diseases related to facial paralysis

Clinical Features for Facial Paralysis

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Drugs & Therapeutics for Facial Paralysis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Facial Paralysis

Drug clinical trials:

Search ClinicalTrials for Facial Paralysis

Search NIH Clinical Center for Facial Paralysis

Search CenterWatch for Facial Paralysis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Facial Paralysis

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Anatomical Context for Facial Paralysis

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32MalaCards
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MalaCards organs/tissues related to Facial Paralysis:

32
Bone, Eye, Skin, Testes, Breast, Heart, Brain, Tongue, Liver, Cortex

Animal Models for Facial Paralysis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Facial Paralysis:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7TGFB1, NF2, HOXB1, SP6, ANKH, TP63
2MP:00053908.6LRP5, HOXB1, NF2, ANKH, CADM1, GSX1
3MP:00053828.5NF2, ANKH, TP63, HOXB1, LRP5, SP6
4MP:00053978.3HOXB1, ANKH, TGFB1, PRF1, GSN, GSX1
5MP:00107718.3NF2, GSN, PRF1, TP63, SP6, TGFB1
6MP:00053898.2TGFB1, GSN, TP63, FKBP4, NF2, ANKH
7MP:00053868.1TP63, LRP5, HOXB1, NF2, ANKH, PRF1
8MP:00053878.1ANKH, PRF1, CADM1, TP63, NF2, HOXB1
9MP:00053767.8TGFB1, GSN, ST18, PRF1, NF2, FKBP4
10MP:00053797.7LRP5, NF2, FKBP4, HOXB1, PRF1, SP6
11MP:00053787.6HOXB1, GSX1, TP63, SP6, LRP5, FKBP4
12MP:00107687.4TGFB1, FKBP4, GSN, PRF1, ANKH, NF2

Publications for Facial Paralysis

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50PubMed
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Articles related to Facial Paralysis:

(show top 50)    (show all 561)
idTitleAuthorsYear
1
Cross-Face Nerve Grafting for Reanimation of Incomplete Facial Paralysis: Quantitative Outcomes Using the FACIAL CLIMA System and Patient Satisfaction. (23818253)
2014
2
Facial nerve paralysis and frey syndrome in an infant following removal of an internal mandibular distraction device. (23714921)
2013
3
Tension adjusted multivectorial static suspension with plantaris tendon in facial paralysis. (23714905)
2013
4
Otitis media and facial paralysis as presenting symptoms of a primary middle ear sarcoidosis. (24026033)
2013
5
Use of an individual mandibular advancement device for an?obstructive sleep apnoea patient with facial paralysis: a short-term follow-up case report. (22329406)
2012
6
Rehabilitation of central facial paralysis with hypoglossal-facial anastomosis. (22935815)
2012
7
Comparison of hemihypoglossal nerve versus masseteric nerve transpositions in the rehabilitation of short-term facial paralysis using the Facial Clima evaluating system. (23096620)
2012
8
Transposition of the hemimasseteric muscle for dynamic rehabilitation of facial paralysis. (22337408)
2012
9
Hypokalemic periodic paralysis, facial dysmorphism and ventricular arrhythmia (clinical triad of Andersen-Tawil syndrome). (23767205)
2012
10
False positive Borrelia serology and facial paralysis due to anaplastic lymphoma mimicking lyme. (22480045)
2012
11
Evaluation and management of the patient with postoperative facial paralysis. (22652950)
2012
12
Experience with 60 adult patients with facial paralysis secondary to tumor extirpation. (22743955)
2012
13
Facial paralysis and lymphocytic facial neuritis in a rhesus macaque (Macaca mulatta) positive for simian retrovirus type D2. (22330582)
2011
14
Efficacy of glial growth factor and nerve growth factor on the recovery of traumatic facial paralysis. (21259064)
2011
15
About the right facial palsy of Charles Bell: was Sir Charles Bell himself really affected by facial paralysis? - Comment on 'peripheral facial palsy in the past. Contributions from Avicenna, Nicolaus Friedreich and Charles Bell'. (19722070)
2009
16
Availability of latissimus dorsi minigraft in smile reconstruction for incomplete facial paralysis: quantitative assessment based on the optical flow method. (19337088)
2009
17
Chronic otitis media and facial paralysis as a presenting feature of Wegener's granulomatosis. (19421673)
2009
18
A prospective randomised controlled study on efficacies of acupuncture and steroid in treatment of idiopathic peripheral facial paralysis. (19942723)
2009
19
Facial paralysis: research and future directions. (18470838)
2008
20
Implanted FNS system in closed-circle may become a way for the restoration of eye blinking and closing function for facial paralysis patient. (18178324)
2008
21
Facial paralysis due to an occult parotid abscess. (18628648)
2008
22
Patients' perspectives on the ocular symptoms of facial paralysis after gold weight implantation. (17664087)
2008
23
Facial nerve paralysis: an unrecognized cause of lower eyelid entropion in the pediatric population. (17413627)
2007
24
Facial motor cortex plasticity in patients with unilateral peripheral facial paralysis. (17656839)
2007
25
New-onset facial paralysis and undiagnosed recurrence of cutaneous malignancy: evaluation and management. (16500480)
2006
26
General practitioners' referral pattern for children with acute facial paralysis. (16175979)
2005
27
Aciclovir or valaciclovir for Bell's palsy (idiopathic facial paralysis). (15266457)
2004
28
Corticosteroids for Bell's palsy (idiopathic facial paralysis). (15495021)
2004
29
To what extent do evaluations of facial paralysis by physicians coincide with self-evaluations by patients: comparison of the Yanagihara method, the House-Brackmann method, and self-evaluation by patients. (12621353)
2003
30
Ceramic representations of facial paralysis in ancient Peru. (14501464)
2003
31
A new classification system for facial paralysis in the clinical setting. (14501327)
2003
32
Acupuncture treatment of facial paralysis caused by craniocerebral trauma in 50 cases. (12747200)
2003
33
Facial paralysis. (12391623)
2002
34
Facial paralysis in childhood hypertension. (11328478)
2001
35
Prospective evaluation of eyelid function with gold weight implant and lower eyelid shortening for facial paralysis. (11255475)
2001
36
Variations on the "baby-sitter" procedure for reconstruction of facial paralysis. (10668752)
2000
37
Validation of objective measure of facial paralysis. (10646741)
2000
38
Insulin-like growth factor-I promotes nerve regeneration through a nerve graft in an experimental model of facial paralysis. (12671244)
1999
39
The effect of unilateral partial facial paralysis on nasofrontal sutural growth: an experimental study in the rabbit. (10359250)
1999
40
Paediatric facial paralysis caused by Lyme borreliosis: a prospective and retrospective analysis. (9790136)
1998
41
Idiopathic facial nerve paralysis (Bell's Palsy) in the Asir Region. (17338006)
1997
42
Iatrogenic facial paralysis prevention. (8972995)
1996
43
Surgical facial nerve decompression for peripheral facial paralysis of diverse causes. (8828273)
1996
44
Congenital unilateral facial paralysis. (8584391)
1996
45
The anatomy of the segmental latissimus dorsi flap for reconstruction of facial paralysis. (7863409)
1994
46
Spirometry and maximal respiratory pressures in patients with facial paralysis. (8417873)
1993
47
Pemphigus vegetans presenting with deafness, otalgia and facial nerve paralysis. (2064948)
1991
48
Congenital oculo-facial paralysis (Moebius syndrome): evidence of dominant inheritance in two families. (2618829)
1989
49
Anotia, facial paralysis, and heart disease. (3973798)
1985
50
Facial paralysis in the uveoparotid fever of Boeck's sarcoid. (13411990)
1957

Genetic Variations for Facial Paralysis

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Expression for genes affiliated with Facial Paralysis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Facial Paralysis

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Pathways for genes affiliated with Facial Paralysis

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Compounds for genes affiliated with Facial Paralysis

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44Novoseek, 59Tocris Bioscience
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Compounds related to Facial Paralysis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cytochalasin d44 5910.7TGFB1, GSN, NF2
2digitonin449.3GSN, CD82
3paraffin449.0TGFB1, TP63, CD82, NF2

GO Terms for genes affiliated with Facial Paralysis

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16Gene Ontology
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Biological processes related to Facial Paralysis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lens fiber cell differentiationGO:07030610.0TGFB1, NF2
2negative regulation of DNA replicationGO:00815610.0TGFB1, NF2
3negative regulation of cell-cell adhesionGO:0224089.9TGFB1, NF2
4cell-cell junction organizationGO:0452169.8TGFB1, NF2, CADM1
5positive regulation of transcription from RNA polymerase II promoterGO:0459448.8HOXB1, LRP5, TP63, GSX1, TGFB1

Products for genes affiliated with Facial Paralysis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Facial Paralysis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet