Aliases & Classifications for Facial Paralysis

MalaCards integrated aliases for Facial Paralysis:

Name: Facial Paralysis 12 72 41 14 69
Facial Palsy 12 28
Bell Palsy 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13934
ICD10 32 G51.0
MeSH 41 D005158
NCIt 46 C26769
UMLS 69 C0015469

Summaries for Facial Paralysis

MalaCards based summary : Facial Paralysis, also known as facial palsy, is related to bell's palsy and geniculate herpes zoster, and has symptoms including sleeplessness, generalized muscle weakness and vertigo/dizziness. An important gene associated with Facial Paralysis is TUBB3 (Tubulin Beta 3 Class III), and among its related pathways/superpathways is N-cadherin signaling events. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and skin, and related phenotypes are cellular and immune system

Wikipedia : 72 Facial nerve paralysis is a common problem that involves the paralysis of any structures innervated by... more...

Related Diseases for Facial Paralysis

Diseases related to Facial Paralysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 bell's palsy 33.6 HOXB1 LIPN
2 geniculate herpes zoster 32.0 CD40LG KANTR
3 camurati-engelmann disease 31.5 LRP5 TGFB1
4 acoustic neuroma 30.5 NF2 TGFB1
5 bone fracture 30.4 LRP5 TGFB1
6 facial hemiatrophy 29.8 CD40LG KANTR
7 cerebellopontine angle tumor 29.7 KANTR NF2
8 hyperostosis 29.2 ANKH LRP5 TGFB1
9 facial palsy, congenital, with ptosis and velopharyngeal dysfunction 12.2
10 facial palsy, familial recurrent peripheral 12.2
11 recurrent peripheral facial palsy 12.1
12 congenital hereditary facial paralysis-variable hearing loss syndrome 12.0
13 deafness, conductive stapedial, with ear malformation and facial palsy 12.0
14 aortic arch interruption, facial palsy, and retinal coloboma 11.9
15 anotia facial palsy cardiac defect 11.9
16 melkersson-rosenthal syndrome 11.3
17 moebius syndrome 11.2
18 neurilemmoma 11.1
19 facial paresis, hereditary congenital, 1 10.9
20 familial amyloidosis, finnish type 10.9
21 pontine tegmental cap dysplasia 10.7
22 charlie m syndrome 10.7
23 evans' syndrome 10.5 CD40LG TGFB1
24 giardiasis 10.4 CD40LG TGFB1
25 amyloid tumor 10.4 NF2 TUBB3
26 pustulosis palmaris et plantaris 10.4 CD40LG TGFB1
27 asthenopia 10.4 CADM1 LIPN
28 norwegian scabies 10.3 CD40LG TGFB1
29 poland syndrome 10.3 HOXA2 TUBB3
30 lattice corneal dystrophy 10.3 GSN TGFB1
31 tukel syndrome 10.3 HOXB1 TUBB3
32 craniodiaphyseal dysplasia 10.3 LRP5 TGFB1
33 trench fever 10.3 CD40LG KANTR
34 cerebral arteritis 10.3 CD40LG KANTR
35 neurotic disorder 10.3 LIPN LRP5
36 brachial plexus neuritis 10.3 CD40LG KANTR
37 japanese spotted fever 10.2 CD40LG KANTR
38 hypotropia 10.2 KANTR TUBB3
39 hypertropia 10.2 KANTR TUBB3
40 foramen magnum meningioma 10.2 KANTR NF2
41 exposure keratitis 10.2 KANTR TUBB3
42 functional colonic disease 10.2 CD40LG KANTR
43 anterior cranial fossa meningioma 10.2 KANTR NF2
44 otitis media 10.2
45 branch retinal artery occlusion 10.2 CD40LG KANTR
46 chronic salpingitis 10.1 CD40LG KANTR
47 polyneuropathy 10.1 CD40LG GSN TUBB3
48 calcific tendinitis 10.1 KANTR TGFB1
49 colonic pseudo-obstruction 10.1 CD40LG KANTR
50 idiopathic neutropenia 10.1 CD40LG TGFB1

Comorbidity relations with Facial Paralysis via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Exposure Keratitis Hypertension, Essential
Ischemic Heart Disease Mechanical Ectropion
Myoclonus and Ataxia Paralytic Lagophthalmos
Parotid Gland Cancer Swallowing Disorders
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Facial Paralysis:



Diseases related to Facial Paralysis

Symptoms & Phenotypes for Facial Paralysis

UMLS symptoms related to Facial Paralysis:


sleeplessness, generalized muscle weakness, vertigo/dizziness, facial paresis, muscle weakness, chronic pain, tremor, syncope, seizures, sciatica, pain, oral manifestations, flaccid muscle tone, headache, back pain, hemifacial paralysis, facial palsy, lower motor neuron, facial palsy, upper motor neuron, ophthalmoplegia, hemiplegia

MGI Mouse Phenotypes related to Facial Paralysis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.09 ANKH CADM1 CD40LG GSN HOXA2 HOXB1
2 immune system MP:0005387 9.92 ANKH CADM1 CD40LG GSN HOXB1 LRP5
3 endocrine/exocrine gland MP:0005379 9.91 CADM1 CD40LG GSN HOXB1 LRP5 NF2
4 mortality/aging MP:0010768 9.91 ANKH CD40LG GSN HOXA2 HOXB1 LRP5
5 craniofacial MP:0005382 9.88 ANKH HOXA2 HOXB1 LRP5 NF2 TGFB1
6 nervous system MP:0003631 9.81 CADM1 CD40LG GSN HOXA2 HOXB1 LRP5
7 respiratory system MP:0005388 9.5 ANKH GSN HOXA2 HOXB1 NF2 TGFB1
8 skeleton MP:0005390 9.23 HOXA2 HOXB1 LRP5 NF2 TGFB1 ANKH

Drugs & Therapeutics for Facial Paralysis

Drugs for Facial Paralysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
3
Acetylcholine Approved Phase 4 51-84-3 187
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5 Antiemetics Phase 4,Phase 3
6 Anti-Inflammatory Agents Phase 4,Phase 3
7 Antineoplastic Agents, Hormonal Phase 4,Phase 3
8 Autonomic Agents Phase 4,Phase 3
9 Gastrointestinal Agents Phase 4,Phase 3
10 glucocorticoids Phase 4,Phase 3
11 Hormone Antagonists Phase 4,Phase 3
12 Hormones Phase 4,Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
14 Methylprednisolone acetate Phase 4,Phase 3
15 Methylprednisolone Hemisuccinate Phase 4,Phase 3
16 Neuroprotective Agents Phase 4,Phase 3
17 Peripheral Nervous System Agents Phase 4,Phase 3
18 Prednisolone acetate Phase 4,Phase 3
19 Prednisolone hemisuccinate Phase 4,Phase 3
20 Prednisolone phosphate Phase 4,Phase 3
21 Protective Agents Phase 4,Phase 3
22 Acyclovir Phase 4
23 Anti-Infective Agents Phase 4,Phase 3
24 Antiviral Agents Phase 4
25 valacyclovir Phase 4
26 abobotulinumtoxinA Phase 4
27 Botulinum Toxins Phase 4
28 Botulinum Toxins, Type A Phase 4
29 Cholinergic Agents Phase 4
30 incobotulinumtoxinA Phase 4
31 Neuromuscular Agents Phase 4
32 Neurotransmitter Agents Phase 4
33 onabotulinumtoxinA Phase 4
34 Vaccines Phase 4,Phase 3
35 Anesthetics Phase 4
36 Anesthetics, Local Phase 4
37 Anti-Arrhythmia Agents Phase 4
38 Central Nervous System Depressants Phase 4
39 Diuretics, Potassium Sparing Phase 4
40 Sodium Channel Blockers Phase 4
41 alpha-methyltyrosine Phase 2
42
Prednisone Approved, Vet_approved 53-03-2 5865
43
Menthol Approved Early Phase 1 2216-51-5 16666
44
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
45
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
46
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
47 Antifungal Agents
48 Dermatologic Agents
49 Keratolytic Agents
50 BB 1101

Interventional clinical trials:

(show all 40)

# Name Status NCT ID Phase Drugs
1 Scandinavian Bell's Palsy Study Completed NCT00510263 Phase 4 Prednisolone + placebo;Valaciclovir + placebo;Prednisolone + valaciclovir;Placebo + placebo
2 Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis Completed NCT03048383 Phase 4 OnabotulinumtoxinA Injectable Product;AbobotulinumtoxinA Injectable Product;Incobotulinumtoxin A Injectable Product
3 Postmarketing Safety Study of Q/LAIV in Subjects 2 Through 49 Years of Age Completed NCT01985997 Phase 4
4 Reinnervation of Facial Muscles After Lengthening Temporalis Myoplasty Terminated NCT01833221 Phase 4 injection of 1% lidocaine, 2mL for facial nerve block
5 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
6 Additional 6-Month Safety Follow-up After Completion of Precursor Study 880801 Completed NCT01604746 Phase 3
7 Quadrant Versus Superficial Parotidectomy Withdrawn NCT01607866 Phase 2, Phase 3
8 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3 Methylprednisoline
9 Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome Terminated NCT01127503 Phase 2 Metyrosine;Placebo
10 The Relationship Between Psychological Factors and Bell's Palsy Unknown status NCT01377766
11 Prednisone and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, CER in China Unknown status NCT01201642 Prednisolone
12 Anthropometric Angular Measurement to Determine Muscle Tonus in Patients With Peripheral Facial Paralysis Completed NCT00903669
13 Microbiologic Findings of Acute Facial Palsy in Children Completed NCT01537952
14 Assessment of the Cross-face Nerve Graft in the Treatment of Facial Paralysis Completed NCT03006783
15 Steroid-Antiviral Treatment in Rehabilitation of Facial Palsy Completed NCT02328079 Steroids (Prednisolone) and Steroids plus Antiviral (Prednisolone + acyclovir)
16 Myofunctional Therapy in Facial Palsy Completed NCT00989209 Botulinum Toxin Type A
17 Randomized Controlled Trial of Acupuncture to Treat Bell's Palsy According to Different Stages Completed NCT00608660
18 A Clinical Study on the Combined Magnetic and Oxygen Treatment for Bell's Palsy Completed NCT01686464 prednisone and valacyclovir treatments
19 Acupuncture With Deqi And Psychological Effects in Treatment of Bell's Palsy Completed NCT00685789
20 Prednisone-Placebo vs Prednisone-Valacyclovir in Bell´s Palsy Completed NCT00561106 prednisone- valacyclovir;prednisone-placebo
21 Study of a New Technique to Improve the Symptoms of Orofacial Discomfort in Patients With Peripheral Facial Paralysis Completed NCT01327157
22 Cognitive Function and Emotional Possessing in Bilateral Facial Palsy Completed NCT02179450
23 Complications in Parotid Surgery Completed NCT02486393
24 Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors Completed NCT02527226
25 Retrospective Clinical Outcome of Parotid Tumor Surgery Completed NCT01983176
26 Clinical Research Core Dental Screening Protocol Completed NCT00090818
27 Ultrasound Evaluation of Tongue Movements in Speech and Swallowing Completed NCT00001167
28 Morphometric Study of the Muscles of the Skin in MRI 3 Tesla in Patients With Facial Paralysis. Recruiting NCT03115203
29 Lengthening Temporalis Myoplasty and Improvement of Primary Swallowing Disorders in Facial Paralysis Recruiting NCT03284125
30 Virtual Rehabilitation Program in Peripheral Facial Paralysis Recruiting NCT02892864
31 The Role of a Device to Evaluate the Neuromuscular Function in Assessing Muscle in Facial Paralysis Patients Recruiting NCT02489162
32 Magnetic Correction of Eye Lid Paralysis Recruiting NCT02988856
33 The Prehospital Selection of Acute Stroke Patients Recruiting NCT03072524
34 Quantification, Analysis and Simulation of Facial Mimics Movements Recruiting NCT02002572
35 R. I. S. POS. T. A Recruiting NCT01991665
36 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
37 Surgery or Clincial Follow up, in Patients With Bell' s Palsy Enrolling by invitation NCT02179684
38 Intratympanic Stereoidal Injections for Facial Nerve Palsy Not yet recruiting NCT03371589 Dexamethasone
39 Two Different Surgical Methods of Blepharospasm Not yet recruiting NCT02765113 Early Phase 1
40 A Multicenter Study to Evaluate a Borrelia Diagnostic Test in Subjects With Early Stage or Late Stage Lyme Disease Terminated NCT02741609

Search NIH Clinical Center for Facial Paralysis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: facial paralysis

Genetic Tests for Facial Paralysis

Genetic tests related to Facial Paralysis:

# Genetic test Affiliating Genes
1 Facial Palsy 28

Anatomical Context for Facial Paralysis

MalaCards organs/tissues related to Facial Paralysis:

38
Bone, Eye, Skin, Testes, Tongue, Cortex, Heart

Publications for Facial Paralysis

Articles related to Facial Paralysis:

(show top 50) (show all 651)
# Title Authors Year
1
The Distal Stump of the Intramuscular Motor Branch of the Obturator Nerve Is Useful for the Reconstruction of Long-Standing Facial Paralysis Using a Double-Powered Free Gracilis Muscle Flap Transfer. ( 29381636 )
2018
2
The effects of lipoic acid and methylprednisolone on nerve healing in rats with facial paralysis<sup/>. ( 29310488 )
2018
3
Societal Identification of Facial Paralysis and Paralysis Location. ( 29423522 )
2018
4
Objective Outcomes of Minimally Invasive Temporalis Tendon Transfer for Prolonged Complete Facial Paralysis. ( 29026828 )
2017
5
Restoration of orbicularis oculi muscle function in rabbits with peripheral facial paralysis via an implantable artificial facial nerve system. ( 29285055 )
2017
6
Validation of the Clinician-Graded Electronic Facial Paralysis Assessment. ( 28338582 )
2017
7
Ipsilateral facial paralysis and steroid acne. ( 28366909 )
2017
8
Lip and Lower Lid Supporting Prosthetic Appliance: A Unique Approach of Treating Unilateral Facial Paralysis. ( 28658922 )
2017
9
An unobtrusive computerized assessment framework for unilateral peripheral facial paralysis. ( 28541917 )
2017
10
Reliability of temporal bone high-resolution CT in patients with facial paralysis in temporal bone fracture. ( 29258690 )
2017
11
Facial paralysis due to Ramsay Hunt syndrome - A rare condition. ( 28614529 )
2017
12
What is the role of imaging in the evaluation of the patient presenting with unilateral facial paralysis? ( 28833220 )
2017
13
Simultaneous Reconstruction of Both Facial Paralysis and Temporomandibular Joint Ankylosis With a Composite Flap From Dorsum of Foot. ( 28891897 )
2017
14
Case analysis of temporal bone lesions with facial paralysis as main manifestation and literature review. ( 28826175 )
2017
15
Differential Reanimation of the Midface and Lower Face Using the Masseteric and Hypoglossal Nerves for Facial Paralysis. ( 29088397 )
2017
16
Importance of Reporting Duration of Facial Paralysis in Studies of Emotion and Well-being. ( 28617900 )
2017
17
Facial Paralysis and Hearing Loss: A Rare Manifestation of Prostate Cancer Metastases. ( 28409073 )
2017
18
Thread lifting: aA minimally invasive surgical technique for long-standing facial paralysis. ( 28567477 )
2017
19
Surgical timing for facial paralysis after temporal bone trauma. ( 28302380 )
2017
20
Partial Facial Paralysis as a Model for Prophylactic Botulinum Toxin Use for the Prevention of Facial Rhytides. ( 28498202 )
2017
21
Familial progressive bilateral facial paralysis in Finnish type hereditary amyloidosis. ( 28578319 )
2017
22
Multivectored Superficial Muscular Aponeurotic System Suspension for Facial Paralysis. ( 28178098 )
2017
23
Facial Reanimation: Basic Surgical Tools and Creation of an Effective Toolbox for Treating Patients with Facial Paralysis: Part B. Nerve Transfer Combined with Cross-Facial Nerve Grafting in the Acute Facial Palsy Patient. ( 28234855 )
2017
24
Refractory Facial Paralysis: A Case Report. ( 29250758 )
2017
25
Importance of Reporting Duration of Facial Paralysis in Studies of Emotion and Well-Being-Reply. ( 28617901 )
2017
26
Comparing Patient, Casual Observer, and Expert Perception of Permanent Unilateral Facial Paralysis. ( 28056121 )
2017
27
Outcome of a graduated minimally invasive facial reanimation in patients with facial paralysis. ( 28391532 )
2017
28
Minimal Nasolabial Incision Technique for Nasolabial Fold Modification in Patients With Facial Paralysis. ( 29049436 )
2017
29
Restoring facial symmetry through non-surgical cosmetic procedures after permanent facial paralysis: a case report. ( 28632885 )
2017
30
Bilateral Facial Paralysis Caused by Temporal Bone Fracture: A Case Report. ( 27679786 )
2016
31
Reply: Lengthening Temporalis Myoplasty for Single-Stage Smile Reconstruction in Children with Facial Paralysis. ( 27437732 )
2016
32
Bilateral Facial Paralysis as Presenting Symptoms in Acute Lymphoblastic Leukemia. ( 27755454 )
2016
33
Restoration of eye closure in facial paralysis using implantable electromagnetic actuator. ( 27642163 )
2016
34
Refractory Granulomatosis with Polyangiitis Presenting as Facial Paralysis and Bilateral Sudden Deafness. ( 27144236 )
2016
35
Assessing psychological distress in patients with facial paralysis using the Hospital Anxiety and Depression Scale. ( 26952127 )
2016
36
Masseteric Nerve as "Baby Sitter" Procedure in Incomplete Facial Paralysis. ( 27200230 )
2016
37
Iatrogenic Phenol Injury Causing Facial Paralysis With Tympanic Membrane and Ossicular Necrosis. ( 26927759 )
2016
38
Adipose-Derived Stem Cells Enhance Axonal Regeneration through Cross-Facial Nerve Grafting in a Rat Model of Facial Paralysis. ( 27465163 )
2016
39
Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review. ( 26825921 )
2016
40
Lengthening Temporalis Myoplasty for Single-Stage Smile Reconstruction in Children with Facial Paralysis. ( 27400432 )
2016
41
The effectiveness of ayurvedic oil-based nasal instillation (Nasya) medicines in the treatment of facial paralysis (Ardita): a systematic review. ( 27532316 )
2016
42
Facial Paralysis Secondary to Extensive Perineural Spread of Adenocarcinoma of the Parotid Gland Identified by PET/CT. ( 26825200 )
2016
43
Emerging vs Time-Tested Methods of Facial Grading Among Patients With Facial Paralysis. ( 27101446 )
2016
44
Mastoiditis and facial paralysis as initial manifestations of temporal bone systemic diseases - the significance of the histopathological examination. ( 27151715 )
2016
45
Yamamoto New Scalp Acupuncture, Applied Kinesiology, and Breathing Exercises for Facial Paralysis in a Young Boy Caused by Lyme Disease-A Case Report. ( 27102135 )
2016
46
Bilateral Facial Paralysis: A 13-Year Experience. ( 27307336 )
2016
47
Association Among Facial Paralysis, Depression, and Quality of Life in Facial Plastic Surgery Patients. ( 27930763 )
2016
48
Neoplastic causes of nonacute facial paralysis: A review of 221 cases. ( 27657317 )
2016
49
Quality of life differences in patients with right- versus left-sided facial paralysis: Universal preference of right-sided human face recognition. ( 27449749 )
2016
50
Evolution of Patients With Immediate Complete Facial Paralysis Secondary to Acoustic Neuroma Surgery. ( 26719351 )
2016

Variations for Facial Paralysis

Expression for Facial Paralysis

Search GEO for disease gene expression data for Facial Paralysis.

Pathways for Facial Paralysis

Pathways related to Facial Paralysis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.14 GSN LRP5

GO Terms for Facial Paralysis

Cellular components related to Facial Paralysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cortical actin cytoskeleton GO:0030864 8.62 GSN NF2

Biological processes related to Facial Paralysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to radiation GO:0009314 9.37 LRP5 TGFB1
2 oligodendrocyte development GO:0014003 9.32 GSN TGFB1
3 cell-cell junction organization GO:0045216 9.26 NF2 TGFB1
4 negative regulation of DNA replication GO:0008156 9.16 NF2 TGFB1
5 negative regulation of cell-cell adhesion GO:0022408 8.96 NF2 TGFB1
6 lens fiber cell differentiation GO:0070306 8.62 NF2 TGFB1

Sources for Facial Paralysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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