Aliases & Classifications for Facial Paralysis

MalaCards integrated aliases for Facial Paralysis:

Name: Facial Paralysis 12 42 14 69
Facial Palsy 12 29
Bell Palsy 69

Classifications:



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Disease Ontology 12 DOID:13934
ICD10 33 G51.0
MeSH 42 D005158
NCIt 47 C26769
UMLS 69 C0015469

Summaries for Facial Paralysis

MalaCards based summary : Facial Paralysis, also known as facial palsy, is related to recurrent peripheral facial palsy and congenital hereditary facial paralysis-variable hearing loss syndrome, and has symptoms including hemiplegia, ophthalmoplegia and oral manifestations. An important gene associated with Facial Paralysis is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways is N-cadherin signaling events. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and testes, and related phenotypes are cellular and immune system

Related Diseases for Facial Paralysis

Diseases related to Facial Paralysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
id Related Disease Score Top Affiliating Genes
1 recurrent peripheral facial palsy 12.0
2 congenital hereditary facial paralysis-variable hearing loss syndrome 11.9
3 deafness, conductive stapedial, with ear malformation and facial palsy 11.9
4 facial palsy, familial recurrent peripheral 11.9
5 anotia facial palsy cardiac defect 11.8
6 bell's palsy 11.8
7 melkersson-rosenthal syndrome 11.2
8 moebius syndrome 11.1
9 facial paresis, hereditary congenital, 1 10.8
10 camurati-engelmann disease 10.8
11 familial amyloidosis, finnish type 10.8
12 trichuriasis 10.7 HOXB1 LIPN
13 renal hypertension 10.7 CD40LG TGFB1
14 long bones of lower limb cancer 10.6 CADM1 LIPN
15 geniculate herpes zoster 10.6
16 charlie m syndrome 10.6
17 pontine tegmental cap dysplasia 10.6
18 pyridoxine deficiency 10.6 CD40LG TGFB1
19 cowpox 10.6 GSN TGFB1
20 thrombophlebitis migrans 10.6 CD40LG TGFB1
21 axial osteomalacia 10.5 LRP5 TGFB1
22 hypoinsulinemic hypoglycemia with hemihypertrophy 10.5 LRP5 TGFB1
23 spinal canal and spinal cord meningioma 10.5 CD40LG KANTR
24 rickettsialpox 10.5 CD40LG KANTR
25 kidney carcinoma in situ 10.4 CD40LG KANTR
26 facial nerve neoplasm 10.4 CD40LG KANTR
27 anal colloid adenocarcinoma 10.4 CD40LG KANTR
28 leiomyoma 10.4 NF2 TGFB1
29 rocky mountain spotted fever 10.4 CD40LG KANTR
30 placental insufficiency 10.4 CD40LG KANTR
31 pyrimidine metabolic disorder 10.4 CD40LG KANTR
32 malignant gastric germ cell tumor 10.4 KANTR NF2
33 central retinal artery occlusion 10.3 CD40LG KANTR
34 central nervous system germ cell tumor 10.3 KANTR NF2
35 iida kannari syndrome 10.3 CD40LG TGFB1
36 lynch syndrome 10.3 CD40LG KANTR
37 macrocystic neurilemmoma 10.3 KANTR NF2
38 hypolipoproteinemia 10.3 CD40LG KANTR
39 peripheral nervous system disease 10.2 CD40LG KANTR
40 polydactyly, postaxial, with progressive myopia 10.2 HOXA2 TUBB3
41 peritoneal benign neoplasm 10.2 KANTR NF2
42 lung lymphoma 10.2 NF2 TUBB3
43 brain injury 10.2 LRP5 TGFB1
44 frozen shoulder 10.1 KANTR TGFB1
45 bacterial meningitis 10.1 KANTR TUBB3
46 otitis media 10.1
47 seminoma 10.1 KANTR NF2
48 microcephaly-micromelia syndrome 10.1 HOXB1 TUBB3
49 esotropia 10.1 KANTR TUBB3
50 post-traumatic stress disorder 10.1 ANKH LRP5 TGFB1

Comorbidity relations with Facial Paralysis via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Exposure Keratitis Geniculate Herpes Zoster
Hypertension, Essential Ischemic Heart Disease
Mechanical Ectropion Paralytic Lagophthalmos
Parotid Gland Cancer Swallowing Disorders
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Facial Paralysis:



Diseases related to Facial Paralysis

Symptoms & Phenotypes for Facial Paralysis

UMLS symptoms related to Facial Paralysis:


hemiplegia, ophthalmoplegia, oral manifestations, sciatica, facial paresis, facial palsy, upper motor neuron, facial palsy, lower motor neuron, hemifacial paralysis, back pain, headache, flaccid muscle tone, pain, seizures, syncope, tremor, chronic pain, muscle weakness, vertigo/dizziness, generalized muscle weakness, sleeplessness

MGI Mouse Phenotypes related to Facial Paralysis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.09 ANKH CADM1 CD40LG GSN HOXA2 HOXB1
2 immune system MP:0005387 9.92 HOXB1 LRP5 NF2 TGFB1 ANKH CADM1
3 endocrine/exocrine gland MP:0005379 9.91 CADM1 CD40LG GSN HOXB1 LRP5 NF2
4 mortality/aging MP:0010768 9.91 ANKH CD40LG GSN HOXA2 HOXB1 LRP5
5 craniofacial MP:0005382 9.88 ANKH HOXA2 HOXB1 LRP5 NF2 TGFB1
6 nervous system MP:0003631 9.81 TGFB1 TUBB3 CADM1 CD40LG GSN HOXA2
7 respiratory system MP:0005388 9.5 ANKH GSN HOXA2 HOXB1 NF2 TGFB1
8 skeleton MP:0005390 9.23 ANKH CD40LG GSN HOXA2 HOXB1 LRP5

Drugs & Therapeutics for Facial Paralysis

Drugs for Facial Paralysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
3
Acetylcholine Approved Phase 4 51-84-3 187
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5 Antiemetics Phase 4,Phase 3
6 Anti-Inflammatory Agents Phase 4,Phase 3
7 Antineoplastic Agents, Hormonal Phase 4,Phase 3
8 Autonomic Agents Phase 4,Phase 3
9 Gastrointestinal Agents Phase 4,Phase 3
10 glucocorticoids Phase 4,Phase 3
11 Hormone Antagonists Phase 4,Phase 3
12 Hormones Phase 4,Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
14 Methylprednisolone acetate Phase 4,Phase 3
15 Methylprednisolone Hemisuccinate Phase 4,Phase 3
16 Neuroprotective Agents Phase 4,Phase 3
17 Peripheral Nervous System Agents Phase 4,Phase 3
18 Prednisolone acetate Phase 4,Phase 3
19 Prednisolone hemisuccinate Phase 4,Phase 3
20 Prednisolone phosphate Phase 4,Phase 3
21 Protective Agents Phase 4,Phase 3
22 Acyclovir Phase 4
23 Anti-Infective Agents Phase 4,Phase 3
24 Antiviral Agents Phase 4
25 valacyclovir Phase 4
26 abobotulinumtoxinA Phase 4
27 Botulinum Toxins Phase 4
28 Botulinum Toxins, Type A Phase 4
29 Cholinergic Agents Phase 4
30 incobotulinumtoxinA Phase 4
31 Neuromuscular Agents Phase 4
32 Neurotransmitter Agents Phase 4,Phase 2
33 onabotulinumtoxinA Phase 4
34 Vaccines Phase 4,Phase 3
35 Anesthetics Phase 4
36 Anesthetics, Local Phase 4
37 Central Nervous System Depressants Phase 4
38 Anti-Arrhythmia Agents Phase 4
39 Diuretics, Potassium Sparing Phase 4
40 Sodium Channel Blockers Phase 4
41
Carbon monoxide Approved Phase 2 630-08-0 281
42 alpha-methyltyrosine Phase 2
43 Antimetabolites Phase 2
44 Cola Nutraceutical Phase 2
45
Prednisone Approved, Vet_approved 53-03-2 5865
46
Menthol Approved Early Phase 1 2216-51-5 16666
47
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
48
Salicylic acid Approved, Vet_approved 69-72-7 338
49
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
50
Sevoflurane Approved, Vet_approved 28523-86-6 5206

Interventional clinical trials:

(show all 42)

id Name Status NCT ID Phase Drugs
1 Scandinavian Bell's Palsy Study Completed NCT00510263 Phase 4 Prednisolone + placebo;Valaciclovir + placebo;Prednisolone + valaciclovir;Placebo + placebo
2 Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis Completed NCT03048383 Phase 4 OnabotulinumtoxinA Injectable Product;AbobotulinumtoxinA Injectable Product;Incobotulinumtoxin A Injectable Product
3 Postmarketing Safety Study of Q/LAIV in Subjects 2 Through 49 Years of Age Completed NCT01985997 Phase 4
4 Reinnervation of Facial Muscles After Lengthening Temporalis Myoplasty Terminated NCT01833221 Phase 4 injection of 1% lidocaine, 2mL for facial nerve block
5 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
6 Additional 6-Month Safety Follow-up After Completion of Precursor Study 880801 Completed NCT01604746 Phase 3
7 Quadrant Versus Superficial Parotidectomy Withdrawn NCT01607866 Phase 2, Phase 3
8 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3 Methylprednisoline
9 Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome Terminated NCT01127503 Phase 2 Metyrosine;Placebo
10 Study of Inhaling Carbon Monoxide to Treat Patients With Intestinal Paralysis After Colon Surgery. Terminated NCT01050712 Phase 2 Inhaled Carbon Monoxide;Synthetic Air
11 The Relationship Between Psychological Factors and Bell's Palsy Unknown status NCT01377766
12 Prednisone and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, CER in China Unknown status NCT01201642 Prednisolone
13 Anthropometric Angular Measurement to Determine Muscle Tonus in Patients With Peripheral Facial Paralysis Completed NCT00903669
14 Microbiologic Findings of Acute Facial Palsy in Children Completed NCT01537952
15 Myofunctional Therapy in Facial Palsy Completed NCT00989209 Botulinum Toxin Type A
16 Steroid-Antiviral Treatment in Rehabilitation of Facial Palsy Completed NCT02328079 Steroids (Prednisolone) and Steroids plus Antiviral (Prednisolone + acyclovir)
17 Assessment of the Cross-face Nerve Graft in the Treatment of Facial Paralysis Completed NCT03006783
18 Randomized Controlled Trial of Acupuncture to Treat Bell's Palsy According to Different Stages Completed NCT00608660
19 A Clinical Study on the Combined Magnetic and Oxygen Treatment for Bell's Palsy Completed NCT01686464 prednisone and valacyclovir treatments
20 Acupuncture With Deqi And Psychological Effects in Treatment of Bell's Palsy Completed NCT00685789
21 Prednisone-Placebo vs Prednisone-Valacyclovir in Bell´s Palsy Completed NCT00561106 prednisone- valacyclovir;prednisone-placebo
22 Study of a New Technique to Improve the Symptoms of Orofacial Discomfort in Patients With Peripheral Facial Paralysis Completed NCT01327157
23 Cognitive Function and Emotional Possessing in Bilateral Facial Palsy Completed NCT02179450
24 Complications in Parotid Surgery Completed NCT02486393
25 Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors Completed NCT02527226
26 Retrospective Clinical Outcome of Parotid Tumor Surgery Completed NCT01983176
27 Clinical Research Core Dental Screening Protocol Completed NCT00090818
28 Ultrasound Evaluation of Tongue Movements in Speech and Swallowing Completed NCT00001167
29 Popliteal Block for Postoperative Pain in Knee-ankle Soft Tissue Surgery in Cerebral Palsy Completed NCT02507700 Sevoflurane;bupivacaine
30 Morphometric Study of the Muscles of the Skin in MRI 3 Tesla in Patients With Facial Paralysis. Recruiting NCT03115203
31 The Role of a Device to Evaluate the Neuromuscular Function in Assessing Muscle in Facial Paralysis Patients Recruiting NCT02489162
32 Magnetic Correction of Eye Lid Paralysis Recruiting NCT02988856
33 The Prehospital Selection of Acute Stroke Patients Recruiting NCT03072524
34 Quantification, Analysis and Simulation of Facial Mimics Movements Recruiting NCT02002572
35 R. I. S. POS. T. A Recruiting NCT01991665
36 A Multicenter Study to Evaluate a Borrelia Diagnostic Test in Subjects With Early Stage or Late Stage Lyme Disease Recruiting NCT02741609
37 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
38 Detection of Arousal With Facial Micro-expression in Severe Brain-damaged Patient Recruiting NCT03023657
39 Surgery or Clincial Follow up, in Patients With Bell' s Palsy Enrolling by invitation NCT02179684
40 Lengthening Temporalis Myoplasty and Improvement of Primary Swallowing Disorders in Facial Paralysis Not yet recruiting NCT03284125
41 Virtual Rehabilitation Program in Peripheral Facial Paralysis Not yet recruiting NCT02892864
42 Two Different Surgical Methods of Blepharospasm Not yet recruiting NCT02765113 Early Phase 1

Search NIH Clinical Center for Facial Paralysis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: facial paralysis

Genetic Tests for Facial Paralysis

Genetic tests related to Facial Paralysis:

id Genetic test Affiliating Genes
1 Facial Palsy 29

Anatomical Context for Facial Paralysis

MalaCards organs/tissues related to Facial Paralysis:

39
Bone, Eye, Testes, Skin, Brain, Tongue, Colon

Publications for Facial Paralysis

Articles related to Facial Paralysis:

(show top 50) (show all 642)
id Title Authors Year
1
An unobtrusive computerized assessment framework for unilateral peripheral facial paralysis. ( 28541917 )
2017
2
Facial Paralysis and Hearing Loss: A Rare Manifestation of Prostate Cancer Metastases. ( 28409073 )
2017
3
Outcome of a graduated minimally invasive facial reanimation in patients with facial paralysis. ( 28391532 )
2017
4
Importance of Reporting Duration of Facial Paralysis in Studies of Emotion and Well-being. ( 28617900 )
2017
5
Restoring facial symmetry through non-surgical cosmetic procedures after permanent facial paralysis: a case report. ( 28632885 )
2017
6
Ipsilateral facial paralysis and steroid acne. ( 28366909 )
2017
7
Lip and Lower Lid Supporting Prosthetic Appliance: A Unique Approach of Treating Unilateral Facial Paralysis. ( 28658922 )
2017
8
Comparing Patient, Casual Observer, and Expert Perception of Permanent Unilateral Facial Paralysis. ( 28056121 )
2017
9
Facial Reanimation: Basic Surgical Tools and Creation of an Effective Toolbox for Treating Patients with Facial Paralysis: Part B. Nerve Transfer Combined with Cross-Facial Nerve Grafting in the Acute Facial Palsy Patient. ( 28234855 )
2017
10
What is the role of imaging in the evaluation of the patient presenting with unilateral facial paralysis? ( 28833220 )
2017
11
Case analysis of temporal bone lesions with facial paralysis as main manifestation and literature review. ( 28826175 )
2017
12
Thread lifting: aA minimally invasive surgical technique for long-standing facial paralysis. ( 28567477 )
2017
13
Validation of the Clinician-Graded Electronic Facial Paralysis Assessment. ( 28338582 )
2017
14
Surgical timing for facial paralysis after temporal bone trauma. ( 28302380 )
2017
15
Partial Facial Paralysis as a Model for Prophylactic Botulinum Toxin Use for the Prevention of Facial Rhytides. ( 28498202 )
2017
16
Multivectored Superficial Muscular Aponeurotic System Suspension for Facial Paralysis. ( 28178098 )
2017
17
Simultaneous Reconstruction of Both Facial Paralysis and Temporomandibular Joint Ankylosis With a Composite Flap From Dorsum of Foot. ( 28891897 )
2017
18
Familial progressive bilateral facial paralysis in Finnish type hereditary amyloidosis. ( 28578319 )
2017
19
Importance of Reporting Duration of Facial Paralysis in Studies of Emotion and Well-Being-Reply. ( 28617901 )
2017
20
Facial paralysis due to Ramsay Hunt syndrome - A rare condition. ( 28614529 )
2017
21
Facial paralysis induced by ear inoculation of herpes simplex virus in rat. ( 27095741 )
2016
22
Yamamoto New Scalp Acupuncture, Applied Kinesiology, and Breathing Exercises for Facial Paralysis in a Young Boy Caused by Lyme Disease-A Case Report. ( 27102135 )
2016
23
Temporalis pull-through vs fascia lata augmentation in facial reanimation for facial paralysis. ( 28299269 )
2016
24
Bilateral Facial Paralysis: A 13-Year Experience. ( 27307336 )
2016
25
Evolution of Patients With Immediate Complete Facial Paralysis Secondary to Acoustic Neuroma Surgery. ( 26719351 )
2016
26
Levator lengthening technique using cartilage or fascia graft for paralytic lagophthalmos in facial paralysis. ( 26952126 )
2016
27
Adipose-Derived Stem Cells Enhance Axonal Regeneration through Cross-Facial Nerve Grafting in a Rat Model of Facial Paralysis. ( 27465163 )
2016
28
Assessing psychological distress in patients with facial paralysis using the Hospital Anxiety and Depression Scale. ( 26952127 )
2016
29
Lengthening Temporalis Myoplasty for Single-Stage Smile Reconstruction in Children with Facial Paralysis. ( 27400432 )
2016
30
Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review. ( 26825921 )
2016
31
The timing of surgical treatment of traumatic facial paralysis: a systematic review. ( 27387924 )
2016
32
Bilateral Facial Paralysis Caused by Temporal Bone Fracture: A Case Report. ( 27679786 )
2016
33
Lengthening temporalis myoplasty versus free muscle transfer with the gracilis flap for long-standing facial paralysis: A systematic review of outcomes. ( 27364924 )
2016
34
Efficient quantitative assessment of facial paralysis using iris segmentation and active contour-based key points detection with hybrid classifier. ( 26968938 )
2016
35
Effect of surgical intervention on middle-ear cholesteatoma with associated facial paralysis. ( 27989248 )
2016
36
Reply: Epidemiological overview of synkinesis in 353 patients with longstanding facial paralysis under treatment with botulinum toxin for 11 years. ( 27088841 )
2016
37
Nerve Transfer for Facial Paralysis Under Intravenous Sedation and Local Analgesia forA the High Surgical Risk Elderly Patient. ( 27060514 )
2016
38
Reply: Epidemiologic Overview of Synkinesis in 353 Patients with Longstanding Facial Paralysis under Treatment with Botulinum Toxin for 11 Years. ( 27465198 )
2016
39
Bilateral Facial Paralysis as Presenting Symptoms in Acute Lymphoblastic Leukemia. ( 27755454 )
2016
40
Asymmetry of Facial Mimicry and Emotion Perception in Patients With Unilateral Facial Paralysis. ( 26892786 )
2016
41
Restoration of eye closure in facial paralysis using implantable electromagnetic actuator. ( 27642163 )
2016
42
Association Between Facial Nerve Monitoring With Postoperative Facial Paralysis in Parotidectomy. ( 27310887 )
2016
43
Bilateral facial paralysis in a non-Hodgkin lymphoma during remission period: a rare but an important condition to be investigated. ( 27321933 )
2016
44
Clinical Efficacy of Electroneurography in Acute Facial Paralysis. ( 27144227 )
2016
45
Mastoiditis and facial paralysis as initial manifestations of temporal bone systemic diseases - the significance of the histopathological examination. ( 27151715 )
2016
46
Emerging vs Time-Tested Methods of Facial Grading Among Patients With Facial Paralysis. ( 27101446 )
2016
47
Facial Paralysis Secondary to Extensive Perineural Spread of Adenocarcinoma of the Parotid Gland Identified by PET/CT. ( 26825200 )
2016
48
Association of Facial Paralysis-Related Disability With Patient- and Observer-Perceived Quality of Life. ( 27253905 )
2016
49
The effectiveness of ayurvedic oil-based nasal instillation (Nasya) medicines in the treatment of facial paralysis (Ardita): a systematic review. ( 27532316 )
2016
50
Gracilis Free Muscle Transfer in the Treatment of Pediatric Facial Paralysis. ( 27097141 )
2016

Variations for Facial Paralysis

Expression for Facial Paralysis

Search GEO for disease gene expression data for Facial Paralysis.

Pathways for Facial Paralysis

Pathways related to Facial Paralysis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.14 GSN LRP5

GO Terms for Facial Paralysis

Cellular components related to Facial Paralysis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cortical actin cytoskeleton GO:0030864 8.62 GSN NF2

Biological processes related to Facial Paralysis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to radiation GO:0009314 9.37 LRP5 TGFB1
2 oligodendrocyte development GO:0014003 9.32 GSN TGFB1
3 cell-cell junction organization GO:0045216 9.26 NF2 TGFB1
4 negative regulation of DNA replication GO:0008156 9.16 NF2 TGFB1
5 negative regulation of cell-cell adhesion GO:0022408 8.96 NF2 TGFB1
6 lens fiber cell differentiation GO:0070306 8.62 NF2 TGFB1

Sources for Facial Paralysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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