Aliases & Classifications for Facial Paralysis

Aliases & Descriptions for Facial Paralysis:

Name: Facial Paralysis 12 42 14 69
Facial Palsy 12 29 14
Bell Palsy 69

Classifications:



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Disease Ontology 12 DOID:13934
ICD10 33 G51.0
MeSH 42 D005158
NCIt 47 C26769
UMLS 69 C0015469

Summaries for Facial Paralysis

MalaCards based summary : Facial Paralysis, also known as facial palsy, is related to recurrent peripheral facial palsy and congenital hereditary facial paralysis-variable hearing loss syndrome, and has symptoms including hemiplegia, ophthalmoplegia and oral manifestations. An important gene associated with Facial Paralysis is LIPN (Lipase Family Member N), and among its related pathways/superpathways is N-cadherin signaling events. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and testes, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Facial Paralysis

Diseases related to Facial Paralysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
id Related Disease Score Top Affiliating Genes
1 recurrent peripheral facial palsy 12.0
2 congenital hereditary facial paralysis-variable hearing loss syndrome 11.9
3 facial palsy, familial recurrent peripheral 11.9
4 deafness, conductive stapedial, with ear malformation and facial palsy 11.9
5 bell's palsy 11.9
6 anotia facial palsy cardiac defect 11.8
7 melkersson-rosenthal syndrome 11.2
8 moebius syndrome 11.1
9 facial paresis, hereditary congenital, 1 10.8
10 familial amyloidosis, finnish type 10.8
11 camurati-engelmann disease 10.8
12 geniculate herpes zoster 10.6
13 pontine tegmental cap dysplasia 10.6
14 cervix uteri carcinoma in situ 10.2 GSN TGFB1
15 thrombophlebitis migrans 10.2 CD40LG TGFB1
16 trichuriasis 10.2 CD40LG HOXB1 LIPN
17 fibrogenesis imperfecta ossium 10.2 LRP5 TGFB1
18 cerebral lipidosis 10.2 CD40LG TGFB1
19 vulvar sarcoma 10.1 CD40LG TGFB1
20 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.1 LIPN LRP5
21 otitis media 10.1
22 malignant neoplasm of short bones of lower limb 10.0 CADM1 LIPN MTRNR2L5
23 bone fracture 10.0
24 spinal canal and spinal cord meningioma 10.0 CD40LG KANTR
25 facial nerve neoplasm 10.0 CD40LG KANTR
26 lipodystrophy, familial partial, type 6 10.0 LRP5 TGFB1
27 spastic ataxia 7, autosomal dominant 10.0 CD40LG KANTR
28 homocystinuria 10.0 CD40LG KANTR
29 spotted fever 10.0 CD40LG KANTR
30 anal canal adenocarcinoma 10.0 CD40LG KANTR
31 subglottic angioma 10.0 KANTR NF2
32 oropharyngeal anthrax 10.0 CD40LG KANTR
33 seminoma 9.9 KANTR NF2
34 ectropion 9.9
35 neuroma 9.9
36 herpes simplex 9.9
37 acoustic neuroma 9.9
38 generalized dystonia 9.9 CD40LG KANTR
39 parotitis 9.9
40 cholesteatoma 9.9
41 lagophthalmos 9.8
42 lymphoma 9.8
43 ptosis 9.8
44 mastoiditis 9.8
45 total third-nerve palsy 9.8 CADM1 KANTR MTRNR2L5
46 nerve fibre bundle defect 9.8 KANTR LIPN MARVELD1
47 hidrocystoma 9.8 CD40LG KANTR
48 amyloidosis 9.8
49 meningitis 9.8
50 skull base neoplasm 9.7

Comorbidity relations with Facial Paralysis via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Exposure Keratitis Geniculate Herpes Zoster
Hypertension, Essential Ischemic Heart Disease
Mechanical Ectropion Paralytic Lagophthalmos
Parotid Gland Cancer Swallowing Disorders
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Facial Paralysis:



Diseases related to Facial Paralysis

Symptoms & Phenotypes for Facial Paralysis

UMLS symptoms related to Facial Paralysis:


hemiplegia, ophthalmoplegia, oral manifestations, sciatica, facial paresis, facial palsy, upper motor neuron, facial palsy, lower motor neuron, hemifacial paralysis, back pain, headache, flaccid muscle tone, pain, seizures, syncope, tremor, chronic pain, muscle weakness, vertigo/dizziness, generalized muscle weakness, sleeplessness

MGI Mouse Phenotypes related to Facial Paralysis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.01 ANKH CADM1 CD40LG GSN HOXA2 HOXB1
2 endocrine/exocrine gland MP:0005379 9.87 CADM1 CD40LG GSN HOXB1 LRP5 NF2
3 immune system MP:0005387 9.86 ANKH CADM1 CD40LG GSN HOXB1 LRP5
4 craniofacial MP:0005382 9.85 HOXB1 LRP5 NF2 TGFB1 ANKH HOXA2
5 nervous system MP:0003631 9.76 HOXB1 LRP5 NF2 TGFB1 CADM1 CD40LG
6 respiratory system MP:0005388 9.43 ANKH GSN HOXA2 HOXB1 NF2 TGFB1
7 skeleton MP:0005390 9.23 ANKH CD40LG GSN HOXA2 HOXB1 LRP5

Drugs & Therapeutics for Facial Paralysis

Drugs for Facial Paralysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
3
Acetylcholine Approved Phase 4,Phase 2 51-84-3 187
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5 Antiemetics Phase 4,Phase 3
6 Anti-Inflammatory Agents Phase 4,Phase 3
7 Antineoplastic Agents, Hormonal Phase 4,Phase 3
8 Autonomic Agents Phase 4,Phase 3
9 Gastrointestinal Agents Phase 4,Phase 3
10 glucocorticoids Phase 4,Phase 3
11 Hormone Antagonists Phase 4,Phase 3
12 Hormones Phase 4,Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
14 Methylprednisolone acetate Phase 4,Phase 3
15 Methylprednisolone Hemisuccinate Phase 4,Phase 3
16 Neuroprotective Agents Phase 4,Phase 3
17 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
18 Prednisolone acetate Phase 4,Phase 3
19 Prednisolone hemisuccinate Phase 4,Phase 3
20 Prednisolone phosphate Phase 4,Phase 3
21 Protective Agents Phase 4,Phase 3
22 Acyclovir Phase 4
23 Anti-Infective Agents Phase 4,Phase 3
24 Antiviral Agents Phase 4
25 valacyclovir Phase 4
26 abobotulinumtoxinA Phase 4,Phase 2
27 Botulinum Toxins Phase 4,Phase 2
28 Botulinum Toxins, Type A Phase 4,Phase 2
29 Cholinergic Agents Phase 4,Phase 2
30 incobotulinumtoxinA Phase 4,Phase 2
31 Neuromuscular Agents Phase 4,Phase 2
32 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
33 onabotulinumtoxinA Phase 4,Phase 2
34 Vaccines Phase 4,Phase 3
35 Anesthetics Phase 4
36 Anesthetics, Local Phase 4
37 Central Nervous System Depressants Phase 4
38 Anti-Arrhythmia Agents Phase 4
39 Diuretics, Potassium Sparing Phase 4
40 Sodium Channel Blockers Phase 4
41
Tenecteplase Approved Phase 3,Phase 2 191588-94-0
42
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
43
Clopidogrel Approved, Nutraceutical Phase 3 120202-66-6, 113665-84-2 60606
44 Fibrinolytic Agents Phase 3,Phase 2
45 Plasminogen Phase 3,Phase 2
46 Platelet Aggregation Inhibitors Phase 3
47 Tissue Plasminogen Activator Phase 3,Phase 2
48 Plasminogen Inactivators Phase 3
49 Purinergic P2 Receptor Antagonists Phase 3
50 Purinergic P2Y Receptor Antagonists Phase 3

Interventional clinical trials:

(show top 50) (show all 66)
id Name Status NCT ID Phase
1 Scandinavian Bell's Palsy Study Completed NCT00510263 Phase 4
2 Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis Completed NCT03048383 Phase 4
3 Postmarketing Safety Study of Q/LAIV in Subjects 2 Through 49 Years of Age Completed NCT01985997 Phase 4
4 Post Marketing Surveillance Study of Dysport Completed NCT00210431 Phase 4
5 Reinnervation of Facial Muscles After Lengthening Temporalis Myoplasty Terminated NCT01833221 Phase 4
6 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3
7 Additional 6-Month Safety Follow-up After Completion of Precursor Study 880801 Completed NCT01604746 Phase 3
8 A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion Recruiting NCT02398656 Phase 3
9 Quadrant Versus Superficial Parotidectomy Withdrawn NCT01607866 Phase 2, Phase 3
10 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3
11 Finding of Optimal Dose for NT 201 in the Treatment of Glabellar Frown Lines Completed NCT00430586 Phase 2
12 TNK-tPA Evaluation for Minor Ischemic Stroke With Proven Occlusion Completed NCT01654445 Phase 2
13 Botulinum Toxin A for Emotional Stabilization in Borderline Personality Disorder (BPD) Recruiting NCT02728778 Phase 2
14 Treatment of Temporo-Myofascial Disorder of Muscular Origin Using Botulinum Toxin: A Prospective Study Not yet recruiting NCT02810015 Phase 2
15 Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome Terminated NCT01127503 Phase 2
16 Study of Inhaling Carbon Monoxide to Treat Patients With Intestinal Paralysis After Colon Surgery. Terminated NCT01050712 Phase 2
17 Safety Study of Inhaling Carbon Monoxide in Healthy Volunteers Terminated NCT01050933 Phase 1
18 The Relationship Between Psychological Factors and Bell's Palsy Unknown status NCT01377766
19 Prednisone and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, CER in China Unknown status NCT01201642
20 ePrime: Evaluation of Magnetic Resonance (MR) Imaging to Predict Neurodevelopmental Impairment in Preterm Infants Unknown status NCT01049594
21 Effect of DBS on Quality of Life in Dyskinetic Cerebral Palsy Unknown status NCT02097693
22 Anthropometric Angular Measurement to Determine Muscle Tonus in Patients With Peripheral Facial Paralysis Completed NCT00903669
23 Microbiologic Findings of Acute Facial Palsy in Children Completed NCT01537952
24 Myofunctional Therapy in Facial Palsy Completed NCT00989209
25 Steroid-Antiviral Treatment in Rehabilitation of Facial Palsy Completed NCT02328079
26 Assessment of the Cross-face Nerve Graft in the Treatment of Facial Paralysis Completed NCT03006783
27 Randomized Controlled Trial of Acupuncture to Treat Bell's Palsy According to Different Stages Completed NCT00608660
28 A Clinical Study on the Combined Magnetic and Oxygen Treatment for Bell's Palsy Completed NCT01686464
29 Acupuncture With Deqi And Psychological Effects in Treatment of Bell's Palsy Completed NCT00685789
30 Prednisone-Placebo vs Prednisone-Valacyclovir in Bell´s Palsy Completed NCT00561106
31 Study of a New Technique to Improve the Symptoms of Orofacial Discomfort in Patients With Peripheral Facial Paralysis Completed NCT01327157
32 Cognitive Function and Emotional Possessing in Bilateral Facial Palsy Completed NCT02179450
33 Complications in Parotid Surgery Completed NCT02486393
34 Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors Completed NCT02527226
35 Retrospective Clinical Outcome of Parotid Tumor Surgery Completed NCT01983176
36 Clinical Research Core Dental Screening Protocol Completed NCT00090818
37 Ultrasound Evaluation of Tongue Movements in Speech and Swallowing Completed NCT00001167
38 Popliteal Block for Postoperative Pain in Knee-ankle Soft Tissue Surgery in Cerebral Palsy Completed NCT02507700
39 Brain Reorganization Following Constraint-Induced Therapy in Children With Cerebral Palsy Completed NCT00100503
40 Botox and Suction-Curettage for Treatment of Excessive Underarm Sweating (Axillary Hyperhidrosis) Completed NCT01274611
41 Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury Completed NCT01882257
42 Tactile Learning in Stroke Patients Completed NCT00283881
43 Natural History in CCFDN and IBM Syndromes Completed NCT01902940
44 MDs on Botox Utility (MOBILITY) Completed NCT00535938
45 Finding the Optimal Voluntary Exercise Parameters for Those Living With Quadriplegia Completed NCT03146728
46 Morphometric Study of the Muscles of the Skin in MRI 3 Tesla in Patients With Facial Paralysis. Recruiting NCT03115203
47 The Role of a Device to Evaluate the Neuromuscular Function in Assessing Muscle in Facial Paralysis Patients Recruiting NCT02489162
48 The Prehospital Selection of Acute Stroke Patients Recruiting NCT03072524
49 Quantification, Analysis and Simulation of Facial Mimics Movements Recruiting NCT02002572
50 R. I. S. POS. T. A Recruiting NCT01991665

Search NIH Clinical Center for Facial Paralysis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: facial paralysis

Genetic Tests for Facial Paralysis

Genetic tests related to Facial Paralysis:

id Genetic test Affiliating Genes
1 Facial Palsy 29

Anatomical Context for Facial Paralysis

MalaCards organs/tissues related to Facial Paralysis:

39
Bone, Eye, Testes, Skin, Heart, Breast, Cortex

Publications for Facial Paralysis

Articles related to Facial Paralysis:

(show top 50) (show all 621)
id Title Authors Year
1
Comparing Patient, Casual Observer, and Expert Perception of Permanent Unilateral Facial Paralysis. ( 28056121 )
2017
2
Association of Facial Paralysis-Related Disability With Patient- and Observer-Perceived Quality of Life. ( 27253905 )
2016
3
Asymmetry of Facial Mimicry and Emotion Perception in Patients With Unilateral Facial Paralysis. ( 26892786 )
2016
4
Emerging vs Time-Tested Methods of Facial Grading Among Patients With Facial Paralysis. ( 27101446 )
2016
5
Bilateral Facial Paralysis as Presenting Symptoms in Acute Lymphoblastic Leukemia. ( 27755454 )
2016
6
Evolution of Patients With Immediate Complete Facial Paralysis Secondary to Acoustic Neuroma Surgery. ( 26719351 )
2016
7
Lengthening temporalis myoplasty versus free muscle transfer with the gracilis flap for long-standing facial paralysis: A systematic review of outcomes. ( 27364924 )
2016
8
The effectiveness of ayurvedic oil-based nasal instillation (Nasya) medicines in the treatment of facial paralysis (Ardita): a systematic review. ( 27532316 )
2016
9
Yamamoto New Scalp Acupuncture, Applied Kinesiology, and Breathing Exercises for Facial Paralysis in a Young Boy Caused by Lyme Disease-A Case Report. ( 27102135 )
2016
10
Reply: Epidemiologic Overview of Synkinesis in 353 Patients with Longstanding Facial Paralysis under Treatment with Botulinum Toxin for 11 Years. ( 27465198 )
2016
11
Refractory Granulomatosis with Polyangiitis Presenting as Facial Paralysis and Bilateral Sudden Deafness. ( 27144236 )
2016
12
Early Nerve Grafting for Facial Paralysis After Cerebellopontine Angle Tumor Resection With Preserved Facial Nerve Continuity. ( 26584060 )
2016
13
Corticosteroids for Bell's palsy (idiopathic facial paralysis). ( 27428352 )
2016
14
Spontaneity of smile after facial paralysis rehabilitation when using a non-facial donor nerve. ( 27460946 )
2016
15
Epidemiologic Overview of Synkinesis in 353 Patients with Longstanding Facial Paralysis under Treatment with Botulinum Toxin for 11 years. ( 27070213 )
2016
16
The timing of surgical treatment of traumatic facial paralysis: a systematic review. ( 27387924 )
2016
17
Levator lengthening technique using cartilage or fascia graft for paralytic lagophthalmos in facial paralysis. ( 26952126 )
2016
18
Facial Paralysis Reconstruction. ( 26902979 )
2016
19
A young woman with acute one-sided facial paralysis. ( 27620636 )
2016
20
Association Between Facial Nerve Monitoring With Postoperative Facial Paralysis in Parotidectomy. ( 27310887 )
2016
21
Lengthening Temporalis Myoplasty for Single-Stage Smile Reconstruction in Children with Facial Paralysis. ( 27400432 )
2016
22
Facial Paralysis Secondary to Extensive Perineural Spread of Adenocarcinoma of the Parotid Gland Identified by PET/CT. ( 26825200 )
2016
23
Efficient quantitative assessment of facial paralysis using iris segmentation and active contour-based key points detection with hybrid classifier. ( 26968938 )
2016
24
Reply: Lengthening Temporalis Myoplasty for Single-Stage Smile Reconstruction in Children with Facial Paralysis. ( 27437732 )
2016
25
Iatrogenic Phenol Injury Causing Facial Paralysis With Tympanic Membrane and Ossicular Necrosis. ( 26927759 )
2016
26
Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review. ( 26825921 )
2016
27
Quality of life differences in patients with right- versus left-sided facial paralysis: Universal preference of right-sided human face recognition. ( 27449749 )
2016
28
Assessing psychological distress in patients with facial paralysis using the Hospital Anxiety and Depression Scale. ( 26952127 )
2016
29
Neoplastic causes of nonacute facial paralysis: A review of 221 cases. ( 27657317 )
2016
30
Nerve Transfer for Facial Paralysis Under Intravenous Sedation and Local Analgesia forA the High Surgical Risk Elderly Patient. ( 27060514 )
2016
31
Effect of surgical intervention on middle-ear cholesteatoma with associated facial paralysis. ( 27989248 )
2016
32
Association Among Facial Paralysis, Depression, and Quality of Life in Facial Plastic Surgery Patients. ( 27930763 )
2016
33
Bilateral Facial Paralysis Caused by Temporal Bone Fracture: A Case Report. ( 27679786 )
2016
34
Periocular Reconstruction in Patients with Facial Paralysis. ( 27040589 )
2016
35
Gracilis Free Muscle Transfer in the Treatment of Pediatric Facial Paralysis. ( 27097141 )
2016
36
Reply: Epidemiological overview of synkinesis in 353 patients with longstanding facial paralysis under treatment with botulinum toxin for 11 years. ( 27088841 )
2016
37
Facial paralysis induced by ear inoculation of herpes simplex virus in rat. ( 27095741 )
2016
38
Mastoiditis and facial paralysis as initial manifestations of temporal bone systemic diseases - the significance of the histopathological examination. ( 27151715 )
2016
39
Masseteric Nerve as "Baby Sitter" Procedure in Incomplete Facial Paralysis. ( 27200230 )
2016
40
Clinical Efficacy of Electroneurography in Acute Facial Paralysis. ( 27144227 )
2016
41
Bilateral facial paralysis in a non-Hodgkin lymphoma during remission period: a rare but an important condition to be investigated. ( 27321933 )
2016
42
Bilateral Facial Paralysis: A 13-Year Experience. ( 27307336 )
2016
43
Weakness of Eye Closure with Central Facial Paralysis after Unilateral Hemispheric Stroke Predicts a Worse Outcome. ( 27986397 )
2016
44
Restoration of eye closure in facial paralysis using implantable electromagnetic actuator. ( 27642163 )
2016
45
Adipose-Derived Stem Cells Enhance Axonal Regeneration through Cross-Facial Nerve Grafting in a Rat Model of Facial Paralysis. ( 27465163 )
2016
46
Quantifying Labial Strength and Function in Facial Paralysis: Effect of Targeted Lip Injection Augmentation. ( 26086151 )
2015
47
Teofilo Folengo's facial paralysis and unknown demise. ( 26105509 )
2015
48
Perspectives in the reconstruction of paediatric facial paralysis. ( 26488534 )
2015
49
Post-Traumatic Bilateral Facial Paralysis Associated with Temporal Bone Fracture. ( 26522201 )
2015
50
Unexpected rare complication of the facial paralysis in a patient with an antrochoanal polyp following canine fossa puncture. ( 25976190 )
2015

Variations for Facial Paralysis

Expression for Facial Paralysis

Search GEO for disease gene expression data for Facial Paralysis.

Pathways for Facial Paralysis

Pathways related to Facial Paralysis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.14 GSN LRP5

GO Terms for Facial Paralysis

Cellular components related to Facial Paralysis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cortical actin cytoskeleton GO:0030864 8.62 GSN NF2

Biological processes related to Facial Paralysis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of osteoblast differentiation GO:0045668 9.46 HOXA2 LRP5
2 response to radiation GO:0009314 9.43 LRP5 TGFB1
3 oligodendrocyte development GO:0014003 9.4 GSN TGFB1
4 cell-cell junction organization GO:0045216 9.37 NF2 TGFB1
5 negative regulation of DNA replication GO:0008156 9.32 NF2 TGFB1
6 osteoblast development GO:0002076 9.26 HOXA2 LRP5
7 negative regulation of cell-cell adhesion GO:0022408 9.16 NF2 TGFB1
8 lens fiber cell differentiation GO:0070306 8.96 NF2 TGFB1
9 anterior/posterior pattern specification GO:0009952 8.8 HOXA2 HOXB1 LRP5

Sources for Facial Paralysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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