MCID: FCT013
MIFTS: 22

Factor V Leiden Thrombophilia malady

Categories: Genetic diseases, Rare diseases, Blood diseases

Aliases & Classifications for Factor V Leiden Thrombophilia

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Aliases & Descriptions for Factor V Leiden Thrombophilia:

Name: Factor V Leiden Thrombophilia 71 23 48 24 25
Hereditary Resistance to Activated Protein C 23 48 24 25
Factor V Leiden Mutation 23 24 68
Apc Resistance, Leiden Type 48 25
 
Thrombophilia Due to Activated Protein C Resistance 68
Thrombosis Risk Factor 24
Thrombophilia V 24
Factor V R506q 24

Characteristics:

GeneReviews:

23
Penetrance: factor v leiden heterozygotes identified from general population screening had a low absolute incidence of vte of approximately two vte events per 1000 persons per year in several studies [juul et al 2004, heit et al 2005]. the cumulative incidence of vte was 6.5% at age 65 years. homozygotes had an absolute incidence of 15 vte events/1000 persons/year [juul et al 2004]...


Classifications:



Summaries for Factor V Leiden Thrombophilia

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NIH Rare Diseases:48 Factor v leiden thrombophilia is a genetic disorder that makes it more likely for you to develop a blood clot sometime during your life. still, it is estimated that 95% of people with factor v leiden never develop a clot. when a clot does form, the clot most often occurs in your leg (deep venous thrombosis or dvt) or lungs (pulmonary embolism or pe). factor v leiden is the name of a specific gene mutation in the f5 gene. this gene plays a role in how your body forms blood clots after an injury. people can inherit one or two copies of the factor v leiden gene mutation. last updated: 1/24/2017

MalaCards based summary: Factor V Leiden Thrombophilia, also known as hereditary resistance to activated protein c, is related to thrombophilia due to activated protein c resistance and thrombosis. An important gene associated with Factor V Leiden Thrombophilia is F5 (Coagulation Factor V). Affiliated tissues include lung.

Genetics Home Reference:25 Factor V Leiden thrombophilia is an inherited disorder of blood clotting. Factor V Leiden is the name of a specific gene mutation that results in thrombophilia, which is an increased tendency to form abnormal blood clots that can block blood vessels.

GeneReviews for NBK1368

Related Diseases for Factor V Leiden Thrombophilia

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Diseases related to Factor V Leiden Thrombophilia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophilia due to activated protein c resistance11.5
2thrombosis10.7
3cerebritis10.4
4budd-chiari syndrome10.4
5thrombophilia10.2
6retinitis10.2
7myocardial infarction10.2
8antiphospholipid syndrome10.2
9inflammatory bowel disease10.1
10portal vein thrombosis10.1
11protein s deficiency10.1
12pulmonary embolism10.1
13hepatitis10.1
14retinal vein occlusion10.1
15breast cancer10.0
16purpura10.0
17polycythemia10.0
18legg-calve-perthes disease9.9
19kienbock's disease9.9
20coronary artery disease9.8
21hemophilia a9.8
22hemophilia9.8

Graphical network of the top 20 diseases related to Factor V Leiden Thrombophilia:



Diseases related to factor v leiden thrombophilia

Symptoms & Phenotypes for Factor V Leiden Thrombophilia

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Drugs & Therapeutics for Factor V Leiden Thrombophilia

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Drugs for Factor V Leiden Thrombophilia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Heparinapproved, investigationalPhase 4, Phase 38489005-49-6772, 46507594
Synonyms:
101921-26-0
102-94-3
102785-31-9
104521-37-1
11078-24-3
11129-39-8
12656-11-0
2-o-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-o-sulfohexopyranuronosyl-(1->4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose
37324-73-5
6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
9041-08-1
9045-22-1
9075-96-1
913079-23-9
91449-79-5
AC1L19ZN
AC1L1ROY
ALFA 87-120
ALFA 87-163
ALFA 87-198
ALFA 87-81
ALFA 88-247
AR-1E4539
Allocinnamic acid
Ardeparin
Ardeparin sodium
Arteven
Bemiparin
Bemiparin sodium
CID772
CID8784
CY 216
Calciparine
Certoparin
Clexane
Clivarin
Clivarine
Cy 222
D006495
D017984
DB00407
DB01225
Dalteparin
Dalteparin sodium
Depo-Heparin
EINECS 232-681-7
EMT 966
EMT 967
EMT-966
EMT-967
EMT966
EMT967
Enoxaparin
Enoxaparin sodium
Enoxaparine
Eparina
Eparina [DCIT]
FR 860
Fluxum
Fragmin A
Fragmin B
Fragmin IV
Fraxiparin
H 2149
HSDB 3094
Hed-heparin
Hep Flush Kit in plastic container
Hep-Lock
Hep-Lock U/P
Hep-lock
Heparin
Heparin CY 216
Heparin Lock Flush
Heparin Lock Flush in plastic container
Heparin Lock Flush preservative free
Heparin Lock Flush preservative free in plastic container
Heparin Sodium
Heparin natrium
Heparin sodium
Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 1,000 units in dextrose 5% in plastic container
Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 10,000 units in dextrose 5%
Heparin sodium 10,000 units in dextrose 5% in plastic container
Heparin sodium 10,000 units in sodium chloride 0.45%
Heparin sodium 10,000 units in sodium chloride 0.9%
Heparin sodium 12,500 units in dextrose 5%
Heparin sodium 12,500 units in dextrose 5% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.9%
Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 2,000 units in dextrose 5% in plastic container
Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 20,000 units and dextrose 5% in plastic container
Heparin sodium 20,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units and dextrose 5% in plastic container
 
Heparin sodium 25,000 units in dextrose 5%
Heparin sodium 25,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.9%
Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units in dextrose 5% in plastic container
Heparin sodium 5,000 units in sodium chloride 0.45%
Heparin sodium 5,000 units in sodium chloride 0.9%
Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
Heparin sodium in plastic container
Heparin sodium preservative Free
Heparin sulfate
Heparin sulphate
Heparin, Low Molecular Weight
Heparin, Low-Molecular-Weight
Heparin, sodium salt
Heparina
Heparina [INN-Spanish]
Heparinate
Heparine
Heparine [INN-French]
Heparinic acid
Heparinsodiumsalt
Heparinum
Heparinum [INN-Latin]
Heparinum natricum
Hepathrom
Hepflush-10
Inno-Hep
Innohep
Isocinnamic acid
KB 101
Kabi 2165
LHN 1
LMWH
Lioton 1000
Lipo-hepin
Liquaemin
Liquaemin Lock Flush
Liquaemin Sodium
Liquaemin sodium preservative free
Liquemin
Logiparin
Lovenox
Lovenox HP
Low Molecular Weight Heparin
Low molecular weight heparin
Low molecular weight heparin sodium
Low-Molecular-Weight Heparin
Minolteparin sodium
MolPort-003-760-257
Multiparin
NSC174025
Nadroparin
Nadroparine
Novoheparin
OP 386
OP 622
Octaparin
PK 10,169
PK-10,169
PK-10169
PK10,169
PK10169
Pabyrin
Panheprin
Parnaparin
Parnaparin sodium
Parvoparin
Pularin
Reviparin
Reviparin sodium
Ro 11
Sandoparin
Sodium acid heparin
Sodium heparin
Sodium heparinate
Subeparin
Sublingula
Thromboliquine
Tinzaparin
Tinzaparin sodium
Triofiban
UNII-12M44VTJ7B
UNII-3S182ET3UA
UNII-E47C0NF7LV
UNII-T2410KM04A
UNII-ZZ45AB24CA
Unfractionated heparin
Vetren
Vitrum AB
WY 90493RD
alpha-Heparin
cis-.beta.-Carboxystyrene
cis-Cinnamic acid
enoxaparin
heparin
2
DalteparinapprovedPhase 4, Phase 33179041-08-1
Synonyms:
Daltepariininatrium
Dalteparin Sodyum
Dalteparin sodium
Dalteparin sodná sůl
Dalteparin-nátrium
Dalteparina sódica
 
Dalteparinnatrium
Dalteparino natrio druska
Dalteparinum Natricum
Dalteparyna sodowa
Daltéparine sodique
Heparin Fragment KABI 2165
Tedelparin
3Heparin, Low-Molecular-WeightPhase 4, Phase 3334
4calcium heparinPhase 4, Phase 3848
5Fibrinolytic AgentsPhase 4, Phase 32388
6AnticoagulantsPhase 4, Phase 32623
7ThrombinPhase 4304
8
Aspirinapproved, vet_approvedPhase 3115250-78-22244
Synonyms:
11126-35-5
11126-37-7
1oxr
2-(Acetyloxy)benzoate
2-(Acetyloxy)benzoic acid
2-Acetoxybenzenecarboxylic acid
2-Acetoxybenzoate
2-Acetoxybenzoic acid
2-Carboxyphenyl acetate
2349-94-2
26914-13-6
50-78-2
8-hour Bayer
98201-60-6
A 5376
A.S.A
A.S.A.
A.S.A. Empirin
A.S.A. empirin
A2093_SIGMA
A3160_SIGMA
A5376_SIGMA
A6810_SIGMA
AB1003266
AC 5230
AC1L1D8U
AC1Q1LA0
ACETYLSALICYLIC ACID
AI3-02956
AIN
AKOS000118884
ASA
Acenterine
Acesal
Acetal
Acetard
Aceticyl
Acetilsalicilico
Acetilum acidulatum
Acetisal
Acetol
Acetonyl
Acetophen
Acetosal
Acetosalic acid
Acetosalin
Acetoxybenzoic acid
Acetylin
Acetylsal
Acetylsalicylate
Acetylsalicylic acid
Acetylsalicylsaeure
Acetylsalicylsaure
Acetylsalicylsäure
Acetylsalycilic acid
Acetyonyl
Acetysal
Acetysalicylic acid
Acide acetylsalicylique
Acido O-acetil-benzoico
Acido acetilsalicilico
Acidum acetylsalicylicum
Acimetten
Acisal
Acylpyrin
Adiro
Aloxiprimum
Asacard
Asagran
Asatard
Ascoden-30
Aspalon
Aspec
Aspergum
Aspir-Mox
Aspirdrops
Aspirin
Aspirin (JP15/USP)
Aspirin [BAN:JAN]
Aspirina 03
Aspirine
Asprin
Aspro
Aspro Clear
Asteric
Azetylsalizylsaeure
Azetylsalizylsäure
BIDD:GT0118
BRN 0779271
Bay-e-4465
Bayer
Bayer Aspirin 8 Hour
Bayer Buffered
Bayer Extra Strength Aspirin For Migraine Pain
Bayer Plus
Benaspir
Bi-prin
Bialpirina
Bialpirinia
Bufferin
C01405
CCRIS 3243
CHEBI:15365
CHEMBL25
CID2244
Caprin
Cardioaspirin
Cardioaspirina
Cemirit
Claradin
Clariprin
Colfarit
Contrheuma retard
Coricidin
Crystar
D00109
D001241
DB00945
Decaten
Delgesic
Dispril
DivK1c_000555
Dolean pH 8
Duramax
ECM
EINECS 200-064-1
EU-0100038
Easprin
Easprin (TN)
Ecolen
Ecotrin
Empirin
Empirin with Codeine
Endosprin
Endydol
Entericin
Enterophen
 
Enterosarein
Enterosarine
Entrophen
Extren
Globentyl
Globoid
HMS1920E13
HMS2090G03
HMS2091K13
HMS501L17
HSDB 652
Helicon
I14-7505
IDI1_000555
Idragin
Istopirin
KBio1_000555
KBio2_001725
KBio2_002271
KBio2_004293
KBio2_004839
KBio2_006861
KBio2_007407
KBio3_002149
KBio3_002751
KBioGR_000398
KBioGR_002271
KBioSS_001725
KBioSS_002272
Kapsazal
Kyselina 2-acetoxybenzoova
Kyselina acetylsalicylova
LS-143
Levius
Lopac-A-5376
Lopac0_000038
MLS001055329
MLS001066332
MLS001336045
MLS001336046
Magnecyl
Measurin
Medisyl
Micristin
MolPort-000-871-622
NCGC00015067-01
NCGC00015067-04
NCGC00015067-09
NCGC00090977-01
NCGC00090977-02
NCGC00090977-03
NCGC00090977-04
NCGC00090977-05
NCGC00090977-06
NCGC00090977-07
NCI60_002222
NINDS_000555
NSC 27223
NSC27223
NSC406186
Neuronika
Novid
Nu-seals
Nu-seals aspirin
O-(Acetyloxy)benzoate
O-(Acetyloxy)benzoic acid
O-Acetoxybenzoate
O-Acetoxybenzoic acid
O-Acetylsalicylic acid
O-Carboxyphenyl acetate
O-accetylsalicylic acid
O-acetylsalicylic acid
PL-2200
Persistin
Pharmacin
Pirseal
Polopirin
Polopiryna
Premaspin
R16CO5Y76E [UNII]
Rheumin tabletten
Rheumintabletten
Rhodine
Rhonal
Ronal
S-211
SMR000059138
SP 189
SPBio_001838
SPECTRUM1500130
ST075414
Salacetin
Salcetogen
Saletin
Salicylic acid acetate
Salicylic acid, acetate
Salospir
Solfrin
Solprin
Solprin acid
Solpyron
Solupsan
Spectrum2_001899
Spectrum3_001295
Spectrum4_000099
Spectrum5_000740
Spectrum_001245
Spira-Dine
St. Joseph
St. Joseph Aspirin for Adults
Supac
Tasprin
Temperal
Toldex
Triaminicin
Triple-sal
UNII R16CO5Y76E
UNII-R16CO5Y76E
UNII=R16CO5Y76E
UNM-0000306102
Vanquish
WLN: QVR BOV1
XAXA
Xaxa
Yasta
ZORprin
acide 2-(acétyloxy)benzoïque
acide acétylsalicylique
aspirin
cMAP_000006
component of Midol
component of Synirin
nchem.859-comp6
o-Acetoxybenzoic acid
o-Carboxyphenyl acetate
o-acetoxybenzoic acid
o-carboxyphenyl acetate
salicylic acid acetate
ácido acetilsalicílico
9
RivaroxabanapprovedPhase 3259366789-02-8
Synonyms:
 
Xarelto
bay 59-7939
10Cyclooxygenase InhibitorsPhase 32870
11Pharmaceutical SolutionsPhase 38192
12Antirheumatic AgentsPhase 310956
13Peripheral Nervous System AgentsPhase 323689
14Platelet Aggregation InhibitorsPhase 32516
15AntipyreticsPhase 31605
16Acetylsalicylic acid lysinatePhase 312
17AnalgesicsPhase 311733
18Analgesics, Non-NarcoticPhase 36501
19Anti-Inflammatory Agents, Non-SteroidalPhase 34443
20Anti-Inflammatory AgentsPhase 310729
21
protease inhibitorsPhase 35471
Synonyms:
 
protease inhibitors
22HIV Protease InhibitorsPhase 35470
23Antithrombin IIIPhase 3690
24Serine Proteinase InhibitorsPhase 3878
25AntithrombinsPhase 3697
26Factor Xa InhibitorsPhase 3411
27serineNutraceuticalPhase 3954
28Nadroparinapproved359041-08-1
29Estrogens2542
30Coagulants1500
31Protein C118
32protein S20
33Immunoglobulins6394
34Antibodies6394
35Factor VIII316
36Antibodies, Antiphospholipid29
37Kavanutraceutical1619000-38-8

Interventional clinical trials:

(show all 16)
idNameStatusNCT IDPhase
1Low Molecular Weight Heparin in Prevention of Recurrent Arteriovenous Graft Thrombosis in Chronic Hemodialysis Patients.Unknown statusNCT01970280Phase 4
2LMWH to Prevent Preeclampsia and Fetal Growth RestrictionTerminatedNCT00260520Phase 4
3Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe PreeclampsiaCompletedNCT00986765Phase 3
4A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge PatientsRecruitingNCT02111564Phase 3
5Prevention of Unexplained Recurrent Abortion by EnoxaparineTerminatedNCT00740545Phase 3
6Assessment of the Prevalence of Major Psychiatric Disorders in a Cohort of Women With Clinical Criteria Corresponding to Pure, Abortive-form, Obstetrical, Antiphospholipid SyndromeCompletedNCT02833194
7Determination of Performance Characteristics of the MassPLEX Factor II/V Leiden TestCompletedNCT01835483
8Factor V Leiden Mutation and Implantation FailureCompletedNCT00194350
9Effect of DT56a (Femarelle) on the Coagulation System in the Treatment of Postmenopausal WomenCompletedNCT00883272
10Study of Abnormal Blood Clotting in Children With StrokeCompletedNCT00001927
11Thrombophilic Risk Factors in Pediatric Patients Diagnosed at the Ha'Emek Medical CenterCompletedNCT00736008
12Study on Antithrombotic Prevention in Thrombophilia and Pregnancy LossRecruitingNCT02385461
13Substudy - Evaluation of Patients With Iliac Vein ThrombosisRecruitingNCT03148548
14Thrombophilic Risk Factors in Preterm and Infants Treated at Ha'Emek Medical Center Between the Years 1990 to 2010RecruitingNCT01443273
15Leiden Trial In Prevention of Post-Operative ThromboEmbolic EventsNot yet recruitingNCT02987946
16Comparative Prevalence of Psychiatric Manifestations in Purely Obstetrical Antiphospholipid SyndromeTerminatedNCT01649479

Search NIH Clinical Center for Factor V Leiden Thrombophilia

Genetic Tests for Factor V Leiden Thrombophilia

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Genetic tests related to Factor V Leiden Thrombophilia:

id Genetic test Affiliating Genes
1 Factor V Leiden Thrombophilia24 F5

Anatomical Context for Factor V Leiden Thrombophilia

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MalaCards organs/tissues related to Factor V Leiden Thrombophilia:

36
Lung

Publications for Factor V Leiden Thrombophilia

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Articles related to Factor V Leiden Thrombophilia:

idTitleAuthorsYear
1
Bilateral Legg-Calve-Perthes Disease and Kienbock's Disease in a Child With Factor V Leiden Thrombophilia: A Case Report. (27698645)
2016
2
Factor V leiden thrombophilia in a female collegiate soccer athlete: a case report. (23675803)
2013
3
Factor V Leiden thrombophilia. (21116184)
2011
4
Factor V Leiden thrombophilia: presentation of three patients and a literature review. (19610561)
2006
5
Factor V Leiden Thrombophilia (20301542)
1993

Variations for Factor V Leiden Thrombophilia

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Expression for genes affiliated with Factor V Leiden Thrombophilia

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Search GEO for disease gene expression data for Factor V Leiden Thrombophilia.

Pathways for genes affiliated with Factor V Leiden Thrombophilia

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GO Terms for genes affiliated with Factor V Leiden Thrombophilia

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Sources for Factor V Leiden Thrombophilia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet