MCID: FCT013
MIFTS: 31

Factor V Leiden Thrombophilia malady

Blood category

Summaries for Factor V Leiden Thrombophilia

Sources:
21Genetics Home Reference, 43NIH Rare Diseases, 34MedlinePlus, 19GeneReviews, 33MalaCards
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NIH Rare Diseases:43 Factor v leiden thrombophilia is an inherited disorder that results in an increased risk of developing abnormal blood clots. factor v leiden is the name of a specific gene mutation in the f5 gene. this gene plays a critical role in the normal formation of blood clots in response to an injury. people can inherit one or two copies of the factor v leiden gene mutation. those who inherit one copy are called heterozygotes. people who inherit two copies of the mutation, one from each parent, are called homozygotes. having the factor v leiden mutation increases your risk for developing a clot in your legs called a deep venous thrombosis (dvt). it also increases your risk of developing a clot that travels through the bloodstream and lodges in the lungs, called a pulmonary embolism (pe). last updated: 6/29/2012

MalaCards: Factor V Leiden Thrombophilia, also known as hereditary resistance to activated protein c, is related to thromboembolism and venous thromboembolism. An important gene associated with Factor V Leiden Thrombophilia is F5 (coagulation factor V (proaccelerin, labile factor)). The drugs mesna and 6-aminocaproic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and lung.

Genetics Home Reference:21 Factor V Leiden thrombophilia is an inherited disorder of blood clotting. Factor V Leiden is the name of a specific gene mutation that results in thrombophilia, which is an increased tendency to form abnormal blood clots that can block blood vessels.

MedlinePlus:34 Bleeding is the loss of blood. it can happen inside or outside the body. bleeding can be a reaction to a cut or other wound. it can also result from an injury to internal organs. there are many situations in which you might bleed. a bruise is bleeding under the skin. some strokes are caused by bleeding in the brain. other bleeding, such as gastrointestinal bleeding, coughing up blood, or vaginal bleeding, can be a symptom of a disease. normally, when you bleed, your blood forms clots to stop the bleeding. severe bleeding may require first aid or a trip to the emergency room. if you have a bleeding disorder, your blood does not form clots normally.

GeneReviews summary for factor-v-leiden

Aliases & Classifications for Factor V Leiden Thrombophilia

Sources:
64Wikipedia, 19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 45Novoseek, 34MedlinePlus, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

factor v leiden thrombophilia 64 19 43 20 21
hereditary resistance to activated protein c 64 19 43 21
apc resistance, leiden type 64 43 21
factor v leiden mutation 19 61
bleeding disorders 64 34
bleeding 45 34
thrombophilia due to deficiency of cofactor for activated protein c, leiden type 64
thrombophilia due to activated protein c resistance 61
activated protein c resistance 61
hemorrhage 61


Related Diseases for Factor V Leiden Thrombophilia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Factor V Leiden Thrombophilia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1356)
idRelated DiseaseScoreTop Affiliating Genes
1thromboembolism11.0
2venous thromboembolism10.9
3portal vein thrombosis10.8
4antiphospholipid syndrome10.7
5angiodysplasia10.7
6protein c deficiency10.7
7acute hemorrhagic conjunctivitis10.7
8stroke, ischemic10.7
9pregnancy loss10.7
10acute conjunctivitis10.7
11stroke, hemorrhagic10.7
12thrombophilia10.6
13argentine hemorrhagic fever10.6
14duodenal ulcer10.6
15brain edema10.6
16acute myocardial infarction10.5
17heparin-induced thrombocytopenia10.5
18purpura fulminans10.5
19portal hypertension10.5
20amyloidosis cerebral10.5
21hereditary amyloidosis10.5
22gastric ulcer10.5
23polycythemia vera10.5
24central retinal vein occlusion10.5
25ovarian hyperstimulation syndrome10.5
26hepatic vein thrombosis10.5
27sepsis10.5
28korean hemorrhagic fever10.5
29pulmonary arteriovenous malformation10.4
30dieulafoy lesion10.4
31hemophilia10.4
32peripheral vascular disease10.4
33coronary artery disease,10.4
34hellp syndrome10.4
35crohn's disease10.4
36hyperhomocysteinemia10.4
37angioedema10.4
38vascular disease10.4
39hypereosinophilic syndrome10.4
40myeloproliferative disorder10.4
41hemophilia b10.4
42mallory-weiss syndrome10.4
43amyloidosis10.3
44prothrombin-related thrombophilia10.3
45thrombophilia due to factor v leiden10.3
46gastrointestinal stromal tumor10.3
47omsk hemorrhagic fever10.3
48thrombophilia due to activated protein c resistance10.3
49arteriovenous malformation10.3
50hemorrhagic thrombocythemia10.3

Graphical network of the top 20 diseases related to Factor V Leiden Thrombophilia:



Diseases related to factor v leiden thrombophilia

Clinical Features for Factor V Leiden Thrombophilia

Drugs & Therapeutics for Factor V Leiden Thrombophilia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Factor V Leiden Thrombophilia

Sources:
20GeneTests
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Genetic tests related to Factor V Leiden Thrombophilia:

id Genetic test Affiliating Genes
1 Factor V Leiden Thrombophilia20 F5

Anatomical Context for Factor V Leiden Thrombophilia

Sources:
33MalaCards
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MalaCards organs/tissues related to Factor V Leiden Thrombophilia:

33
Skin, Brain, Lung, Heart

Animal Models for Factor V Leiden Thrombophilia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Factor V Leiden Thrombophilia

Sources:
51PubMed
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Articles related to Factor V Leiden Thrombophilia:

idTitleAuthorsYear
1
Ocular vascular thrombotic events: a diagnostic window to familial thrombophilia (compound factor V Leiden and prothrombin gene heterozygosity) and thrombosis. (18796459)
2009
2
Type and location of venous thromboembolism in patients with factor V Leiden or prothrombin G20210A and in those with no thrombophilia. (17067362)
2007
3
Mechanical prosthetic heart valve thrombosis despite optimal anticoagulation in a patient with congenital thrombophilia (factor V Leiden). (12643329)
2003
4
Heritability of elevated factor VIII antigen levels in factor V Leiden families with thrombophilia. (10886197)
2000
5
Risk of recurrent venous thromboembolism in patients with the factor V Leiden (FVR506Q) mutation: effect of warfarin and prediction by precipitating factors. East Anglian Thrombophilia Study Group. (9531346)
1998
6
Protein C deficiency in a controlled series of unselected outpatients: an infrequent but clear risk factor for venous thrombosis (Leiden Thrombophilia Study) (7742536)
1995
7
Factor VII and fibrinogen levels as risk factors for venous thrombosis. A case-control study of plasma levels and DNA polymorphisms--the Leiden Thrombophilia Study (LETS). (7974338)
1994

Genetic Variations for Factor V Leiden Thrombophilia

Expression for genes affiliated with Factor V Leiden Thrombophilia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Factor V Leiden Thrombophilia

Search GEO for disease gene expression data for Factor V Leiden Thrombophilia.

Pathways for genes affiliated with Factor V Leiden Thrombophilia

Compounds for genes affiliated with Factor V Leiden Thrombophilia

GO Terms for genes affiliated with Factor V Leiden Thrombophilia

Products for genes affiliated with Factor V Leiden Thrombophilia

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Sources for Factor V Leiden Thrombophilia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet