MCID: FCT007
MIFTS: 63

Factor Vii Deficiency malady

Categories: Genetic diseases, Rare diseases, Blood diseases, Liver diseases

Aliases & Classifications for Factor Vii Deficiency

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Aliases & Descriptions for Factor Vii Deficiency:

Name: Factor Vii Deficiency 49 32 10 11 45 22 47 12 67 36 65
Hypoproconvertinemia 45 22 67
Factor 7 Deficiency 45 67 24
Congenital Proconvertin Deficiency 45 67
 
F7 Deficiency 45 67
Deficiency, Stable 10
Stable Disease 47
Fa7d 67

Characteristics:

HPO:

61
factor vii deficiency:
Onset and clinical course: variable expressivity
Inheritance: autosomal recessive inheritance


Classifications:



External Ids:

OMIM49 227500
Disease Ontology10 DOID:2215
ICD1027 D68.2
SNOMED-CT59 154820003, 37193007
MeSH36 D005168
MedGen34 C0015503
UMLS65 C0015503

Summaries for Factor Vii Deficiency

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UniProtKB/Swiss-Prot:67 Factor VII deficiency: A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.

MalaCards based summary: Factor Vii Deficiency, also known as hypoproconvertinemia, is related to acquired hemophilia a and factor x deficiency, and has symptoms including intramuscular hematoma, reduced factor vii activity and joint hemorrhage. An important gene associated with Factor Vii Deficiency is F7 (Coagulation Factor VII), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Warfarin Pathway, Pharmacodynamics. The drugs recombinant fviia and factor ix,recombinant have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and breast, and related mouse phenotypes are embryo and cardiovascular system.

OMIM:49 Factor VII deficiency is an autosomal recessive bleeding disorder showing variable severity (summary by Millar et al.,... (227500) more...

Wikipedia:68 Factor VII (EC 3.4.21.21, blood-coagulation factor VIIa, activated blood coagulation factor VII,... more...

Related Diseases for Factor Vii Deficiency

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Diseases related to Factor Vii Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1acquired hemophilia a31.0F10, F5, F9
2factor x deficiency25.3EGF, F10, F2, F3, F5, F7
3congenital factor vii deficiency12.3
4central nervous system osteosarcoma10.5F2, F3
5esophagus melanoma10.5F2, F3
6epiglottitis10.5F2, F3
7cyclothymic disorder10.5F2, F3
8fowler's syndrome10.5F2, F3
9von willibrand disease, type 310.5F2, F3
10vaginal villous adenoma10.4F2, F3
11cavernous hemangioma of colon10.4F2, F3
12silo filler's disease10.4F2, F3
13herpes gestationis10.4F2, F3
14acquired thrombocytopenia10.4F2, F3
15abducens nerve neoplasm10.4F2, F3
16hypertrichosis10.4F2, F3
17microcytic anemia10.4F2, F3
18splenic abscess10.4F2, F3
19glossopharyngeal nerve neoplasm10.4F10, F3
20kidney sarcoma10.4F2, F3
21nephropathia epidemica10.4F2, F3
22meniere's disease10.3F2, F3
23tricuspid valve disease10.3F2, F3
24babesiosis10.3F3, F9
25malignant fibroxanthoma10.3F7, F9
26gallbladder leiomyosarcoma10.3F7, F9
27fructose intolerance10.3F2, F7
28horner's syndrome10.2F7, F9
29van maldergem syndrome 210.2F2, F3
30skull base meningioma10.2F2, F3, F7
31benign epilepsy with centrotemporal spikes10.2F3, F5
32hemophilia10.2
33sertoli cell tumor10.2F3, F5
34catatrichy10.2F3, F5
35coagulation protein disease10.1F3, F5
36hemophilia a10.1
37tetanus10.1F3, F5
38dubin-johnson syndrome10.0
39hemophilia b10.0
40cerebritis10.0
41morbid obesity10.0F5, F7
42tall stature-scoliosis-macrodactyly of the great toes syndrome10.0F2, F5
43dentin dysplasia10.0F2, F3
44basilar artery insufficiency10.0F2, F3
45liver failure acute infantile10.0F2, F5
46sugarman brachydactyly10.0F2, F5
47internuclear ophthalmoplegia10.0F2, F5
48pericardial mesothelioma10.0F2, F5
49microscopic colitis10.0F2, F5
50fissured tongue10.0F2, F5

Graphical network of the top 20 diseases related to Factor Vii Deficiency:



Diseases related to factor vii deficiency

Symptoms for Factor Vii Deficiency

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Symptoms by clinical synopsis from OMIM:

227500

Clinical features from OMIM:

227500

HPO human phenotypes related to Factor Vii Deficiency:

(show all 6)
id Description Frequency HPO Source Accession
1 intramuscular hematoma HP:0012233
2 reduced factor vii activity HP:0008169
3 joint hemorrhage HP:0005261
4 intracranial hemorrhage HP:0002170
5 epistaxis HP:0000421
6 menorrhagia HP:0000132

Drugs & Therapeutics for Factor Vii Deficiency

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Drugs for Factor Vii Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 74)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Tranexamic AcidapprovedPhase 42261197-18-85526
Synonyms:
08455_FLUKA
1197-17-7
1197-18-8
1ceb
3-14-00-00868 (Beilstein Handbook Reference)
4-(Aminomethyl)-Cyclohexanecarboxylic Acid
4-(Aminomethyl)cyclohexanecarboxylic acid
4-(aminomethyl)cyclohexane-1-carboxylic acid
857653_ALDRICH
A0236
AB00052260
AB1003647
AC-4687
AC1L1KJH
AC1Q50F3
AC1Q546D
AC1Q5U04
ALBB-006013
AMCA
AMCHA
AMH
AR-1F6595
Acide tranexamique
Acide tranexamique [INN-French]
Acido tranexamico
Acido tranexamico [INN-Spanish]
Acidum tranexamicum
Acidum tranexamicum [INN-Latin]
Amikapron
Amstat
Anvitoff
BAY 3517
BPBio1_000069
BRN 2207452
BSPBio_000061
BSPBio_002837
CAS-1197-18-8
CHEBI:48669
CHEMBL292500
CHEMBL877
CID5526
CL 65336
CL-65336
Carxamin
Cyclocapron
Cyklokapron
Cyklokapron (TN)
D01136
DB00302
DV 79
DV-79
DV79
DivK1c_000655
EINECS 214-818-2
Emorhalt
Exacyl
Frenolyse
HMS1568D03
HMS1921F08
HMS2092P03
HMS502A17
Hexapromin
Hexatron
I04-0993
IDI1_000655
KABI 2161
KBio1_000655
KBio2_001871
KBio2_004439
KBio2_007007
KBio3_002337
KBioGR_000511
KBioSS_001871
 
LS-56611
LS-56612
LT00159441
Lysteda
Mastop
MolPort-001-792-390
MolPort-002-512-008
NCGC00016569-01
NCGC00016569-02
NCGC00016569-03
NCGC00094944-01
NCGC00094944-02
NINDS_000655
NSC 291305
NSC291305
Oprea1_786414
Prestwick0_000171
Prestwick1_000171
Prestwick2_000171
Prestwick3_000171
Prestwick_476
RP 18,429
Rikavarin
Rikavarin (TN)
Rikavarin-S
SPBio_000689
SPBio_001982
SPECTRUM1502026
STK503668
STOCK1N-16183
Spectrum2_000655
Spectrum3_001189
Spectrum4_000046
Spectrum5_001258
Spectrum_001391
Spiramin
Tamcha
Tranex
Tranexamate
Tranexamic Acid
Tranexamic acid (JP15/USAN/INN)
Tranexamic acid [USAN:INN:BAN:JAN]
Tranexamic acid cis-form
Tranexamsaeure
Tranexan
Tranexmic acid
Tranhexamic acid
Trans AMCHA
Trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid
Trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid
Trans-p-(Aminomethyl)cyclohexanecarboxylic
Transamin
Transamin (TN)
Transamlon
Trasamlon
UNII-6T84R30KC1
Ugurol
WLN: L6TJ AVQ D1Z -T
cis-4-(Aminomethyl)cyclohexanecarboxylic acid
cis-4-Aminomethylcyclohexane-1-carboxylic acid
cis-AMCHA
t-AMCHA
tranexamic acid
tranexmic acid
trans-1-Aminomethylcyclohexane-4-carboxylic acid
trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid
trans-4-(Aminomethyl)cyclohexane-carboxylic acid
trans-4-(Aminomethyl)cyclohexanecarboxylic acid
trans-4-(Aminomethyl)cyclohexanecarboxylic acid ester
trans-4-Aminomethylcyclohexane-1-carboxylic acid
trans-4-aminomethylcyclohexane-1-carboxylic acid
trans-Amcha
trans-Tranexamic acid
trans-p-(Aminomethyl)cyclohexanecarboxylic acid
2AnticoagulantsPhase 4, Phase 31760
3Antifibrinolytic AgentsPhase 4346
4CoagulantsPhase 4, Phase 31042
5ThrombinPhase 4, Phase 3269
6Factor VIIIPhase 4272
7HemostaticsPhase 4, Phase 31082
8
Cyclophosphamideapproved, investigationalPhase 2264350-18-0, 6055-19-22907
Synonyms:
(+-)-Cyclophosphamide
(-)-Cyclophosphamide
(RS)-Cyclophosphamide
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
4-Hydroxy-cyclophosphan-mamophosphatide
50-18-0
60007-95-6
6055-19-2 (monohydrate)
75526-90-8
AC1L1EQQ
AI3-26198
ASTA
ASTA B518
Asta B 518
B 518
B-518
BRN 0011744
BSPBio_002099
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
C 0768
C07888
C7H15Cl2N2O2P
CB 4564
CB-4564
CCRIS 188
CHEBI:4027
CHEMBL32520
CHEMBL88
CID2907
CP
CPA
CTX
CY
Ciclofosfamida
Ciclofosfamida [INN-Spanish]
Ciclofosfamide
Ciclophosphamide
Ciclophosphamide [INN]
Clafen
Claphene
Cycloblastin
Cyclophosphamid
Cyclophosphamide
Cyclophosphamide (INN)
Cyclophosphamide (TN)
Cyclophosphamide (anhydrous form)
Cyclophosphamide (anhydrous)
Cyclophosphamide Monohydrate
Cyclophosphamide Sterile
Cyclophosphamide anhydrous
Cyclophosphamide, (+-)-Isomer
Cyclophosphamides
Cyclophosphamidum
Cyclophosphamidum [INN-Latin]
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclophosphoramide
Cyclostin
Cyklofosfamid
Cyklofosfamid [Czech]
Cytophosphan
Cytophosphane
Cytoxan
Cytoxan (TN)
Cytoxan Lyoph
D,L-Cyclophosphamide
D07760
DB00531
 
DivK1c_000246
EINECS 200-015-4
EU-0100238
Endoxan
Endoxan R
Endoxan-Asta
Endoxana
Endoxanal
Endoxane
Enduxan
Genoxal
HMS2090A12
HSDB 3047
Hexadrin
IDI1_000246
KBio1_000246
KBio2_001338
KBio2_003906
KBio2_006474
KBio3_001319
KBioGR_000888
KBioSS_001338
LS-1302
LS-99787
Ledoxina
Lopac-C-0768
Lopac0_000238
Lyophilized Cytoxan
Mitoxan
MolPort-001-783-420
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
NCGC00015209-01
NCGC00015209-03
NCGC00015209-06
NCGC00091741-02
NCGC00091741-03
NCI-C04900
NCI60_002097
NINDS_000246
NSC 26271
NSC-26271
NSC26271
NSC273033
NSC273034
Neosar
Occupation, cyclophosphamide exposure
Procytox
RCRA waste no. U058
Rcra Waste Number U058
Rcra waste number U058
Revimmune
S1217_Selleck
SK 20501
SPBio_001071
STK177249
STOCK2S-91217
Semdoxan
Sendoxan
Senduxan
Spectrum2_001146
Spectrum3_000370
Spectrum4_000304
Spectrum5_000795
Spectrum_000858
UNII-6UXW23996M
WLN: T6MPOTJ BO BN2G2G
Zyklophosphamid
Zyklophosphamid [German]
bis(2-Chloroethyl)phosphami de cyclic propanolamide
bis(2-Chloroethyl)phosphamide cyclic propanolamide ester
cyclophosphamide
9
MethylprednisoloneapprovedPhase 2108283-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
A-methapred
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Depo-medrol
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Solu-medrol
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
10
Mycophenolate mofetilapproved, investigationalPhase 2898128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate Mofetil
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil
11
FludarabineapprovedPhase 2105921679-14-1, 75607-67-930751
Synonyms:
(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
2-F-ara-A
2-Fluoro Ara-A
2-Fluoro-9-beta-D-arabinofuranosyladenine
2-Fluoro-ara AMP
2-Fluoroadenine arabinoside 5'-monophosphate
21679-14-1
2F-Ara-AMP
9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate
9-beta-D-Arabinofuranosyl-2-fluoroadenine
9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)
9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate
9-beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine
9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- (9CI)
AC1LCW8I
AC1Q51CF
C10H12FN5O4
CCRIS 3382
CHEMBL1568
CID657237
CPD000058874
D07966
EINECS 244-525-5
F-Ara-A
FAMP
FT-0082766
FaraA
Fludara
 
Fludara, Fludarabine
Fludarabina
Fludarabina [Spanish]
Fludarabine
Fludarabine (INN)
Fludarabine 5'-monophosphate
Fludarabine Phosphate
Fludarabine [INN]
Fludarabine monophosphate
Fludarabine phosphate
Fludarabinum
Fludarabinum [Latin]
Fludura
Fluradosa
Fluradosa (TN)
HSDB 6964
I14-4978
LS-15061
MLS000028687
NSC 118218
NSC 118218H
NSC-118218
Oforta
S1491_Selleck
SAM002548956
SMR000058874
SQ Fludarabine
UNII-1X9VK9O1SC
UNII-P2K93U8740
ZINC04216238
12
AcetylcysteineapprovedPhase 2293616-91-112035
Synonyms:
(2R)-2-acetylamino-3-Sulfanylpropanoic acid
(R)-2-acetylamino-3-Mercaptopropanoic acid
(R)-Mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
 
Fluprowit
L-Acetylcysteine
L-alpha-acetamido-beta-Mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-ACETYL-L-cysteine
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
13
PrednisoloneapprovedPhase 2108250-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
Flo-pred
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
MLS001304083
 
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
Millipred
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Omnipred
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
14
Busulfanapproved, investigationalPhase 250655-98-12478
Synonyms:
1, 4-Dimethanesulfonoxybutane
1, 4-Dimethylsulfonoxybutane
1, {4-Bis[methanesulfonoxy]butane}
1,4-BUTANEDIOL DIMETHANESULFONATE
1,4-Bis(methanesulfonoxy)butane
1,4-Bis(methanesulfonyloxy)butane
1,4-Bis[methanesulfonoxy]butane
1,4-Butanedi yl dimethanesulfonate
1,4-Butanediol dimethanesulfonate
1,4-Butanediol dimethanesulphonate
1,4-Butanediol dimethylsulfonate
1,4-Butanediol, dimethanesulfonate
1,4-Butanediol, dimethanesulphonate
1,4-Butanediyl dimethanesulfonate
1,4-Di(methylsulfonoxy)butane
1,4-Dimesyloxybutane
1,4-Dimethane sulfonyl oxybutane
1,4-Dimethanesulfonoxybutane
1,4-Dimethanesulfonoxylbutane
1,4-Dimethanesulfonyloxybutane
1,4-Dimethanesulphonyloxybutane
1,4-Dimethylsulfonoxybutane
1,4-Dimethylsulfonyloxybutane
2041 C. B
2041 C. B.
2041 C.B
2041 C.B.
4-((Methylsulfonyl)oxy)butyl methanesulfonate
4-methylsulfonyloxybutyl methanesulfonate
55-98-1
AC-198
AC1L1DRQ
AC1Q4GRQ
AI3-25012
AKOS003614975
AN 33501
Ambap55-98-1
B1022
B2635_FLUKA
B2635_SIGMA
BRN 1791786
BSPBio_001920
BUSULFAN (1,4-BUTANEDIOL, DIMETHANESULFONATE)
Bisulfex
Busilvex
Busulfan
Busulfan (JP15/USP/INN)
Busulfan GlaxoSmithKline Brand
Busulfan Orphan Brand
Busulfan Wellcome
Busulfan Wellcome Brand
Busulfan [INN:JAN]
Busulfano
Busulfano [INN-Spanish]
Busulfanum
Busulfanum [INN-Latin]
Busulfex
Busulphan
Busulphane
Butanedioldimethanesulfonate
Buzulfan
C.B. 2041
C6H14O6S2
CB 2041
CCRIS 418
CHEBI:28901
CHEMBL820
CID2478
CPD000058613
Citosulfan
D002066
D00248
DB01008
DivK1c_000847
EINECS 200-250-2
FT-0083567
G.T. 41
GT 2041
GT 41
Glaxo Wellcome Brand of Busulfan
GlaxoSmithKline Brand of Busulfan
Glyzophrol
HMS1920I07
HMS2091O09
HMS502K09
 
HSDB 7605
I09-1371
IDI1_000847
InChI=1/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
KBio1_000847
KBio2_000512
KBio2_003080
KBio2_005648
KBio3_001420
KBioGR_000698
KBioSS_000512
LS-1358
Leucosulfan
MLS001076666
MYLERAN (TN)
Mablin
Methanesulfonic
Methanesulfonic acid, tetram ethylene ester
Methanesulfonic acid, tetramethylene ester
Mielevcin
Mielosan
Mielucin
Milecitan
Mileran
Misulban
Mitosan
Mitostan
MolPort-001-783-406
Myeleukon
Myeloleukon
Myelosan
Myelosanum
Mylecytan
Myleran
Myleran Tablets
Myleran tablets
Myleran, Busulfex, Busulfan
Mylerlan
NCGC00090905-01
NCGC00090905-02
NCGC00090905-03
NCGC00090905-04
NCGC00090905-05
NCGC00090905-06
NCGC00090905-07
NCI-C01592
NCI60_041640
NCIMech_000192
NINDS_000847
NSC 750
NSC-750
NSC-750sulphabutin
NSC750
Orphan Brand of Busulfan
Prestwick_989
S1692_Selleck
SAM002554887
SMR000058613
SPBio_000253
SPECTRUM1500152
ST50825921
Spectrum2_000067
Spectrum3_000320
Spectrum4_000259
Spectrum5_000928
Spectrum_000092
Sulfabutin
Sulfabutin (VAN)
Sulphabutin
Tetramethylene Dimethane Sulfonate
Tetramethylene bis(methanesulfonate)
Tetramethylene bis[methanesulfonate]
Tetramethylene dimethane sulfonate
Tetramethylene {bis[methanesulfonate]}
Tetramethylenester Kyseliny Methansulfonove
Tetramethylenester kyseliny methansulfonove
Tetramethylenester kyseliny methansulfonove [Czech]
UNII-G1LN9045DK
WLN: WS1&O4OSW1
Wellcome Brand of Busulfan
Wellcome, Busulfan
X 149
acid, tetramethylene ester
alkylating agent: crosslinks guanine residues
busulfan
butane-1,4-diyl dimethanesulfonate
n-Butane-1,3-di(methylsulfonate)
15
Mycophenolic acidapprovedPhase 289824280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
Melbex
 
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolic Acid
Mycophenolsaeure
Myfortic
16
Celecoxibapproved, investigationalPhase 2419169590-42-52662
Synonyms:
169590-42-5
184007-95-2
1oq5
4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1Hpyrazol-1-yl] benzenesulfonamide
4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
AC-4228
AC1L1E6K
AI-525
BIDD:GT0408
BRD-K02637541-001-02-4
BSPBio_003596
Benzenesulfonamide,4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)
C07589
C105934
C17H14F3N3O2S
CCRIS 8679
CEL
CEP-33222
CHEBI:41423
CHEMBL118
CID2662
CPD000550473
Celebra
Celebrex
Celebrex (TN)
Celebrex, Celebra, Celecoxib
Celecox
Celecoxi
Celecoxib
Celecoxib (JAN/USAN/INN)
Celecoxib (SC-58635)
Celecoxib [Old RN]
Celecoxib [USAN]
Celecoxibum
Celocoxib
Célécoxib
D00567
DB00482
DivK1c_000893
Eurocox
FT-0080064
HMS1922G14
HMS2089L18
HMS2093I07
HMS502M15
HSDB 7038
I01-1033
IDI1_000893
KBio1_000893
KBio2_000912
 
KBio2_002351
KBio2_003480
KBio2_004919
KBio2_006048
KBio2_007487
KBio3_002830
KBio3_003037
KBioGR_000723
KBioGR_002351
KBioSS_000912
KBioSS_002354
LS-31667
MLS001165684
MLS001195656
MLS001304708
Medicoxib
MolPort-002-885-815
NCGC00091455-01
NCGC00091455-02
NCGC00091455-03
NCGC00091455-04
NCI60_041049
NINDS_000893
NSC719627
Onsenal
P-(5-P-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide
Pfizer brand of celecoxib
S1261_Selleck
SAM002589995
SC 58635
SC-58553, SC-58635
SC-58635
SC58635
SMR000550473
SPBio_001512
SPECTRUM1503678
Solexa
Spectrum2_001576
Spectrum3_001996
Spectrum4_000182
Spectrum5_001324
Spectrum_000432
TL8001323
TPI-336
UNM-0000305813
Xilebao
YM 177
YM-177
YM177
ZINC02570895
cMAP_000027
celecoxib
p-(5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide
17
Vitamin Eapproved, nutraceuticalPhase 237159-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-alpha-tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'r)-alpha-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-alpha-tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitamin e
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
d-alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
18
Folic Acidapproved, nutraceuticalPhase 2292459-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
19Neuroprotective AgentsPhase 21376
20
MesnaPhase 22433375-50-6598
Synonyms:
2-Mercaptoethanesulfonate
2-Mercaptoethanesulfonic acid
 
CoM
Coenzyme M
HS-CoM
21lenograstimPhase 21134
22Methylprednisolone acetatePhase 21082
23Methylprednisolone HemisuccinatePhase 21082
24MicronutrientsPhase 23901
25Prednisolone hemisuccinatePhase 21082
26TocotrienolsPhase 2372
27TocopherolsPhase 2376
28Trace ElementsPhase 23900
29Vitamin B ComplexPhase 22847
30VitaminsPhase 23857
31Thioctic AcidPhase 2104
32Respiratory System AgentsPhase 23931
33Prednisolone acetatePhase 21082
34Peripheral Nervous System AgentsPhase 218510
35KrestinPhase 2189
36Prednisolone phosphatePhase 21082
37Protective AgentsPhase 25651
38N-monoacetylcystinePhase 2293
39Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 29988
40Antilymphocyte SerumPhase 2388
41Immunosuppressive AgentsPhase 210422
42AntimetabolitesPhase 29454
43Antimetabolites, AntineoplasticPhase 25770
44Antineoplastic Agents, AlkylatingPhase 23406
45Anti-Infective AgentsPhase 217220
46AntiemeticsPhase 23213
47Adjuvants, ImmunologicPhase 21783
48Alkylating AgentsPhase 23582
49Anti-Bacterial AgentsPhase 29140
50Antibiotics, AntitubercularPhase 25971

Interventional clinical trials:

(show all 14)
idNameStatusNCT IDPhase
1A Comparison Study of Bypassing Agent Therapy With and Without Tranexamic Acid in Haemophilia A Patients With InhibitorCompletedNCT01800435Phase 4
2Efficacy and Safety of Prothromplex Total (Prothrombin Complex Concentrate) in Oral Anticoagulant ReversalCompletedNCT01159210Phase 4
3Prothrombin Complex Concentrate for Anticoagulant ReversalCompletedNCT00168077Phase 3
4MT2013-31: Allo HCT for Metabolic Disorders and Severe OsteopetrosisRecruitingNCT02171104Phase 2
5Bioequivalence of NovoSeven® and a NovoSeven® Formulation Stable at Room Temperature in Healthy Male SubjectsCompletedNCT01561417Phase 1
6Study of the Pharmacokinetics and Safety of Recombinant Factor VIIa Fusion Protein (rVIIa-FP, CSL689) in Patients With Congenital Factor VII DeficiencyRecruitingNCT02470871Phase 1
7Treatment of Inherited Factor VII DeficiencyCompletedNCT01269138
8Treatment of Congenital Factor VII DeficiencyCompletedNCT01779921
9Observational Study on Safety and Efficacy of NovoSeven® in Subjects With Congenital FVII DeficiencyCompletedNCT01312636
10Observational Study on the Efficacy and Safety of NovoSeven® During "Real-life" Usage in GermanyCompletedNCT00697320
11Study of the Pathobiology of Bronchopulmonary Dysplasia in NewbornsCompletedNCT00006058
12Global Haemostatic Methods Following Administration of Bypassing Agents to Patients With Haemophilia With InhibitorsRecruitingNCT02453542
13An Observational Cohort Study to Investigate the Risk of Thromboembolic Events in Patients Receiving Kcentra® or Plasma to Reverse Vitamin K Antagonist (VKA) Therapy in the Setting of Acute Major BleedingRecruitingNCT02319460
14Allogeneic Hematopoietic Stem Cell Transplant For Epidermolysis BullosaTerminatedNCT00478244

Search NIH Clinical Center for Factor Vii Deficiency

Inferred drug relations via UMLS65/NDF-RT43:

Show with subtypes


Cochrane evidence based reviews: factor vii deficiency

Genetic Tests for Factor Vii Deficiency

About this section

Genetic tests related to Factor Vii Deficiency:

id Genetic test Affiliating Genes
1 Factor Vii Deficiency22 F7

Anatomical Context for Factor Vii Deficiency

About this section

MalaCards organs/tissues related to Factor Vii Deficiency:

33
Liver, Heart, Breast, Prostate, Thyroid, Colon, Skin

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Factor Vii Deficiency:
id TissueAnatomical CompartmentCell Relevance
1 LiverLiver LobuleHepatocytes Potential therapeutic candidate

Animal Models for Factor Vii Deficiency or affiliated genes

About this section

MGI Mouse Phenotypes related to Factor Vii Deficiency:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.5F2, F3, F5, F9, HNF4A
2MP:00053857.8F10, F2, F3, F5, F7, F9
3MP:00053766.4F10, F2, F3, F5, F7, F9
4MP:00107686.2F10, F2, F3, F5, F7, F9

Publications for Factor Vii Deficiency

About this section

Articles related to Factor Vii Deficiency:

(show top 50)    (show all 365)
idTitleAuthorsYear
1
Synergistic effect of factor VII gene polymorphisms causing mild factor VII deficiency in a case of severe factor X deficiency. (26919454)
2016
2
Factor VII deficiency presenting as a possible child abuse. (25796593)
2015
3
A rare combination: congenital factor VII deficiency with Chiari malformation. (26248161)
2015
4
A novel homozygous missense mutation in the factor VII gene of severe factor VII deficiency in a pedigree: a description of two cases. (23672839)
2013
5
Is prophylaxis required for delivery in women with factor VII deficiency? (23607277)
2013
6
Congenital Factor VII Deficiency in Children at Tertiary Health Care Facility in Pakistan. (24322277)
2013
7
Lethal factor VII deficiency due to novel mutations in the F7 promoter: functional analysis reveals disruption of HNF4 binding site. (22628013)
2012
8
Is the coexistence of thromboembolic events and Factor VII deficiency fortuitous? (23026661)
2012
9
Mutation in the factor VII hepatocyte nuclear factor 4I+-binding site contributes to factor VII deficiency. (21760481)
2011
10
The use of tissue thromboplastins of different origin is a fundamental tool in the initial characterization of FVII defects on "factor VII deficiency (Semin Thromb Hemost 2009;35(4):400-406)". (20391303)
2010
11
Using a minigene approach to characterize a novel splice site mutation in human F7 gene causing inherited factor VII deficiency in a Chinese pedigree. (19601987)
2009
12
Clinical management of thrombosis in inherited factor VII deficiency: a description of two cases. (19190828)
2009
13
Acquired factor VII deficiency associated with Wilms tumor. (19137513)
2009
14
Factor VII Deficiency. (19598068)
2009
15
U1-snRNA-mediated rescue of mRNA processing in severe factor VII deficiency. (18156490)
2008
16
Successful coronary artery bypass graft surgery in severe congenital factor VII deficiency: perioperative treatment with factor VII concentrate. (17938818)
2007
17
The use of recombinant activated factor VII in the circumcision operation in the case of a congenital factor VII deficiency. (17473581)
2007
18
Bleeding prophylaxis in a child with cleft palate and factor VII deficiency: a case report. (16405366)
2006
19
Life-threatening bleeding in a patient with a lupus inhibitor and probable acquired factor VII deficiency. (17102654)
2006
20
Visually disabling non-traumatic orbital hemorrhage in an anticoagulated patient with factor VII deficiency. (16518172)
2006
21
Inhibitor to factor VII in severe factor VII deficiency: detection and course of the inhibitory response. (15842376)
2005
22
The significance of published polymorphisms in 14 cases of mild factor VII deficiency. (15741795)
2005
23
Mild factor VII deficiency due to heterozygosis is not associated with a bleeding tendency. (16093739)
2005
24
Severe menorrhagia due to factor VII deficiency successfully treated by thermal balloon endometrial ablation. (12555005)
2003
25
Genotypic heterogeneity may explain phenotypic variations in inherited factor VII deficiency. (11869950)
2002
26
Factor VII deficiency and a copper metabolism disorder in a patient with Klippel-Trenaunay syndrome. (12037456)
2002
27
Acquired factor VII deficiency in hematopoietic stem cell transplant recipients. (11919730)
2002
28
Prophylactic therapy in a pregnant woman with severe factor VII deficiency. (11093053)
2000
29
Two novel factor VII gene mutations in a Chinese family with factor VII deficiency. (11091194)
2000
30
Factor VII deficiency in a mixed breed dog. (10416073)
1999
31
Postoperative bleeding with factor VII deficiency: case report. (9973704)
1998
32
Acquired isolated factor VII deficiency during sepsis. (9212352)
1997
33
Fatal intracranial hemorrhage in a newborn with factor VII deficiency. (8701495)
1996
34
Ala244Val is a common, probably ancient mutation causing factor VII deficiency in Moroccan and Iranian Jews. (8883260)
1996
35
Severe factor VII deficiency caused by mutations abolishing the cleavage site for activation and altering binding to tissue factor. (8204879)
1994
36
Intracranial hemorrhage in an adult with factor-VII deficiency. (8250020)
1994
37
Hereditary factor VII deficiency in pregnancy: peripartum treatment with factor VII concentrate. (1566745)
1992
38
Acquired bleeding disorder in a patient with congenital factor VII deficiency. (1912032)
1991
39
Factor VII clotting assay: influence of different thromboplastins and factor VII-deficient plasmas. CISMEL Study Group. (2053102)
1991
40
Recurrent intracranial hemorrhage in an infant with congenital factor VII deficiency. (3114082)
1987
41
Carriers of factor VII deficiency are not always asymptomatic. (3830535)
1985
42
Congenital factor VII deficiency and cerebrovascular stroke. (2865471)
1985
43
Hereditary Factor VII deficiency in newborns. (6617058)
1983
44
Hemophilia B with associated factor VII deficiency: a distinct variant of hemophilia B with low factor VII activity and normal factor VII antigen. (7370439)
1980
45
Congenital factor VII deficiency presenting as iron deficiency anaemia--Case report. (522751)
1979
46
Intracranial hemorrhage in congenital factor VII deficiency. (423024)
1979
47
Bloody tears due to congenital factor VII deficiency. (677644)
1978
48
Treatment of congenital factor VII deficiency with a new concentrate. (705696)
1978
49
Hereditary factor VII deficiency and increased contact activation time. (868799)
1977
50
Congenital factor VII deficiency. Two cases in children of cousins. (5769051)
1969

Variations for Factor Vii Deficiency

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UniProtKB/Swiss-Prot genetic disease variations for Factor Vii Deficiency:

67 (show all 107)
id Symbol AA change Variation ID SNP ID
1F7p.Arg139LysVAR_006497
2F7p.Arg139GlnVAR_006498rs150525536
3F7p.Arg139TrpVAR_006499
4F7p.Gly157SerVAR_006500
5F7p.Gly157CysVAR_006501
6F7p.Gln160ArgVAR_006502
7F7p.Pro194ThrVAR_006503
8F7p.Lys197GluVAR_006504
9F7p.Arg212GlnVAR_006505
10F7p.Cys238TyrVAR_006506
11F7p.Arg283TrpVAR_006507
12F7p.Ala304ValVAR_006508
13F7p.Arg307HisVAR_006509
14F7p.Glu325LysVAR_006510
15F7p.Ala354ValVAR_006511rs36209567
16F7p.Met358IleVAR_006512
17F7p.Met358ValVAR_006513
18F7p.Arg364GlnVAR_006514rs121964926
19F7p.Cys370PheVAR_006515
20F7p.Gly402ArgVAR_006516
21F7p.Gly402GluVAR_006517
22F7p.Thr419MetVAR_006519
23F7p.Leu13ProVAR_014391
24F7p.Cys389GlyVAR_014392
25F7p.Leu73GlnVAR_014405rs45572939
26F7p.Glu79GlnVAR_014406
27F7p.Cys121PheVAR_014407
28F7p.Leu125ProVAR_014408
29F7p.Tyr128CysVAR_014409
30F7p.Cys151SerVAR_014410
31F7p.Gly157ValVAR_014411
32F7p.Cys195ArgVAR_014412
33F7p.Thr241AsnVAR_014413
34F7p.Asp302HisVAR_014414
35F7p.Asp302AsnVAR_014415
36F7p.Ala304ThrVAR_014416
37F7p.Arg307CysVAR_014417
38F7p.Thr332MetVAR_014418
39F7p.Gly391SerVAR_014419rs190485816
40F7p.Gly435GluVAR_014420
41F7p.Phe64LeuVAR_015135
42F7p.Ser120ProVAR_015136
43F7p.Glu154LysVAR_015137rs146795869
44F7p.Gly216AspVAR_015138
45F7p.Cys254TyrVAR_015139
46F7p.Ala266ThrVAR_015140
47F7p.Val312MetVAR_015141
48F7p.Val341PheVAR_015142
49F7p.Pro363ArgVAR_015143
50F7p.Asp403HisVAR_015144
51F7p.Cys82PheVAR_065370
52F7p.Cys82ArgVAR_065371
53F7p.Glu85LysVAR_065373
54F7p.Arg88GlyVAR_065374
55F7p.Arg88ProVAR_065375
56F7p.Asn117AspVAR_065376
57F7p.Gly138AspVAR_065377
58F7p.Gly156SerVAR_065378
59F7p.Ser171PheVAR_065379
60F7p.Gly177ArgVAR_065380
61F7p.Leu181ProVAR_065381
62F7p.Asp183AsnVAR_065382
63F7p.Ser186PheVAR_065383
64F7p.Pro189SerVAR_065384
65F7p.Pro194LeuVAR_065385
66F7p.Ile198ThrVAR_065386
67F7p.Gly240ArgVAR_065387
68F7p.Ser250PheVAR_065388
69F7p.Ala251ProVAR_065389
70F7p.Ala251ThrVAR_065390
71F7p.Cys254ArgVAR_065391
72F7p.Leu264ProVAR_065392
73F7p.Asp272AsnVAR_065393
74F7p.Asp277AsnVAR_065394
75F7p.Thr298IleVAR_065395
76F7p.His301GlnVAR_065396
77F7p.Leu314ValVAR_065397
78F7p.Leu321PheVAR_065398
79F7p.Leu323ArgVAR_065399
80F7p.Arg326GlnVAR_065400
81F7p.Arg337CysVAR_065401
82F7p.Gly343SerVAR_065402
83F7p.Trp344ArgVAR_065403
84F7p.Gly345SerVAR_065404
85F7p.Arg350CysVAR_065405
86F7p.Leu360ProVAR_065406
87F7p.Pro363HisVAR_065407
88F7p.Arg364TrpVAR_065408
89F7p.Arg375TrpVAR_065409rs137919286
90F7p.Thr384MetVAR_065410
91F7p.Met387ThrVAR_065411
92F7p.Met387ValVAR_065412
93F7p.Phe388SerVAR_065413
94F7p.Gly391CysVAR_065414
95F7p.Asp398GluVAR_065415
96F7p.Lys401GluVAR_065416
97F7p.Ser404AsnVAR_065417
98F7p.His408GlnVAR_065418rs121964936
99F7p.His408ArgVAR_065419
100F7p.Arg413GlyVAR_065420
101F7p.Gly414CysVAR_065421
102F7p.Val422PheVAR_065422
103F7p.Gly425AlaVAR_065423
104F7p.Gly425CysVAR_065424
105F7p.Ala429ThrVAR_065425
106F7p.Gly432AspVAR_065426
107F7p.Tyr437PheVAR_065427

Clinvar genetic disease variations for Factor Vii Deficiency:

5 (show all 21)
id Gene Variation Type Significance SNP ID Assembly Location
1F7F7, CYS310PHEsingle nucleotide variantPathogenic
2F7F7, CYS178TYRsingle nucleotide variantPathogenic
3F7F7, ARG247HISsingle nucleotide variantPathogenic
4F7F7, THR359METundetermined variantPathogenic
5F7F7, ALA244VALsingle nucleotide variantPathogenic
6F7F7, ASN57ASPsingle nucleotide variantPathogenic
7F7F7, IVS4DS, G-A, +1single nucleotide variantPathogenic
8F7NM_000131.4(F7): c.38T> C (p.Leu13Pro)single nucleotide variantPathogenicrs387906507GRCh37Chr 13, 113760193: 113760193
9F7NM_000131.4(F7): c.1061C> T (p.Ala354Val)single nucleotide variantPathogenicrs36209567GRCh37Chr 13, 113772982: 113772982
10F7NM_000131.4(F7): c.849_865del17 (p.Arg284Hisfs)deletionPathogenicrs786205091GRCh37Chr 13, 113772770: 113772786
11F7F7, 1-BP DEL, 11128CdeletionPathogenic
12F7F7, -61T-Gsingle nucleotide variantPathogenic
13F7F7, -94C-Gsingle nucleotide variantPathogenic
14F7F7, -55C-Tsingle nucleotide variantPathogenic
15F7F7, CYS61TERundetermined variantPathogenic
16F7NM_000131.4(F7): c.1165T> G (p.Cys389Gly)single nucleotide variantPathogenicrs121964934GRCh37Chr 13, 113773086: 113773086
17F7NM_000131.4(F7): c.628C> T (p.Gln210Ter)single nucleotide variantPathogenicrs267606790GRCh37Chr 13, 113771136: 113771136
18F7F7, GLU25LYSundetermined variantPathogenic
19F7NM_000131.4(F7): c.1224T> G (p.His408Gln)single nucleotide variantPathogenicrs121964936GRCh37Chr 13, 113773145: 113773145
20F7F7, GLY354CYSundetermined variantPathogenic
21F7NM_000131.4(F7): c.983T> C (p.Phe328Ser)single nucleotide variantPathogenicrs387906508GRCh37Chr 13, 113772904: 113772904

Expression for genes affiliated with Factor Vii Deficiency

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Search GEO for disease gene expression data for Factor Vii Deficiency.

Pathways for genes affiliated with Factor Vii Deficiency

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Pathways related to Factor Vii Deficiency according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7F2, HNF4A
28.7F10, F2, F7, F9
3
Show member pathways
8.7F10, F2, F7, F9
4
Show member pathways
7.8F10, F2, F3, F5, F7, F9
5
Show member pathways
7.8F10, F2, F3, F5, F7, F9
6
Show member pathways
7.8F10, F2, F3, F5, F7, F9
7
Show member pathways
7.3EGF, F10, F2, F3, F5, F7

GO Terms for genes affiliated with Factor Vii Deficiency

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Cellular components related to Factor Vii Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:00057888.5F10, F5, F7, F9

Biological processes related to Factor Vii Deficiency according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-glutamic acid carboxylationGO:001718710.3F2, F7
2blood coagulation, extrinsic pathwayGO:000759810.2F10, F7
3positive regulation of blood coagulationGO:003019410.2F2, F7
4response to woundingGO:000961110.0F2, F3
5signal peptide processingGO:00064659.5F10, F2, F9
6positive regulation of cell migrationGO:00303359.4F10, F3, F7
7cellular protein metabolic processGO:00442679.2F2, F5, F7
8post-translational protein modificationGO:00436878.7F10, F5, F9
9blood coagulationGO:00075967.4EGF, F10, F2, F5, F7, F9

Molecular functions related to Factor Vii Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.6EGF, F2

Sources for Factor Vii Deficiency

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet