FA10D
MCID: FCT003
MIFTS: 61

Factor X Deficiency (FA10D) malady

Categories: Genetic diseases, Rare diseases, Blood diseases

Aliases & Classifications for Factor X Deficiency

About this section

Aliases & Descriptions for Factor X Deficiency:

Name: Factor X Deficiency 52 11 48 24 25 70 12 50 39 13 68
Stuart-Prower Factor Deficiency 48 24 25 54 70
F10 Deficiency 48 25 70
Congenital Stuart Factor Deficiency 25 54
Factor 10 Deficiency 70 27
Hereditary Factor X Deficiency Disease 68
 
Stuart Factor Deficiency, Congenital 48
Factor X Deficiency, Congenital 48
Congenital Factor X Deficiency 54
Disease, Stuart-Prower 11
Fa10d 70

Characteristics:

Orphanet epidemiological data:

54
stuart-prower factor deficiency:
Inheritance: Autosomal recessive; Age of onset: All ages; Age of death: any age

HPO:

64
factor x deficiency:
Inheritance: autosomal recessive inheritance
Onset and clinical course: variable expressivity

Classifications:



External Ids:

OMIM52 227600
Disease Ontology11 DOID:2222
MeSH39 D005171
SNOMED-CT62 76642003
Orphanet54 ORPHA328
ICD10 via Orphanet31 D68.2
MedGen37 C0015519

Summaries for Factor X Deficiency

About this section
NIH Rare Diseases:48 Factor x deficiency is a rare condition that affects the blood's ability to clot. the severity of the condition and the associated signs and symptoms can vary significantly from person to person. common features of factor x deficiency may include easy bruising, frequent nosebleeds, bleeding gums, blood in the urine, and prolonged bleeding after minor injuries. affected women may also experience heavy menstrual bleeding and may have an increased risk for first trimester miscarriages. acquired (non-inherited) factor x deficiency, which is the most common form of the condition, generally occurs sporadically in people with no family history of the condition. acquired factor x deficiency has a variety of causes including liver disease, vitamin k deficiency, exposure to certain medications that affect clotting, and cancers. the inherited form of factor x deficiency (also called congenital factor x deficiency) is caused by changes (mutations) in the f10 gene and is inherited in an autosomal recessive manner. treatment aims to control bleeding through intravenous (iv) infusions of plasma or concentrates of clotting factors. last updated: 11/12/2015

MalaCards based summary: Factor X Deficiency, also known as stuart-prower factor deficiency, is related to hemarthrosis and membranoproliferative glomerulonephritis, and has symptoms including menorrhagia, gingival bleeding and epistaxis. An important gene associated with Factor X Deficiency is F10 (Coagulation Factor X), and among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Warfarin Pathway, Pharmacodynamics. Affiliated tissues include liver, skin and lung, and related mouse phenotypes are embryo and cardiovascular system.

UniProtKB/Swiss-Prot:70 Factor X deficiency: A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.

Genetics Home Reference:25 Factor X deficiency is a rare bleeding disorder that varies in severity among affected individuals. The signs and symptoms of this condition can begin at any age, although the most severe cases are apparent in childhood. Factor X deficiency commonly causes nosebleeds, easy bruising, bleeding under the skin, bleeding of the gums, blood in the urine (hematuria), and prolonged or excessive bleeding following surgery or trauma. Women with factor X deficiency can have heavy or prolonged menstrual bleeding (menorrhagia) or excessive bleeding in childbirth, and may be at increased risk of pregnancy loss (miscarriage). Bleeding into joint spaces (hemarthrosis) occasionally occurs. Severely affected individuals have an increased risk of bleeding inside the skull (intracranial hemorrhage), in the lungs (pulmonary hemorrhage), or in the gastrointestinal tract, which can be life-threatening.

OMIM:52 Factor X deficiency is a rare autosomal recessive bleeding disorder showing variable phenotypic severity. Affected... (227600) more...

Wikipedia:71 Factor X, also known by the eponym Stuart–Prower factor, is an enzyme (EC 3.4.21.6) of the... more...

Related Diseases for Factor X Deficiency

About this section

Diseases related to Factor X Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1hemarthrosis29.7F2, F3
2membranoproliferative glomerulonephritis29.1F2, F3, F9, SERPINC1, VWF
3amyloidosis10.3
4congenital insensitivity to pain with severe intellectual disability10.3F2, F5
5porphyria10.3F2, F7
6lubinsky syndrome10.3F2, F5
7high anorectal malformation10.2F10, VWF
8supraumbilical midabdominal raphe and facial cavernous hemangiomas10.2F2, F5
9hendra virus infection10.2F2, F3, F5
10seminoma10.2F2, F3, F7
11dyskinetic cerebral palsy10.2F11, F2, F3
12von willibrand disease, type 310.2F7, VWF
13oxyphilic adenoma10.2F2, F5
14invasive pneumococcal disease, recurrent isolated, 110.2F10, F2, F5
15low anorectal malformation10.2F2, F3, F5
16alpha-2-macroglobulin deficiency10.2F2, F3, VWF
17miller-dieker lissencephaly syndrome10.2F2, SERPINC1
18sporotrichosis10.2F2, F3
19acromegaloid hypertrichosis syndrome10.2F11, F9, VWF
20sertoli cell tumor10.2F3, SERPINC1
21stt3a-cdg and stt3b-cdg10.2F5, SERPINC1
22hereditary endotheliopathy, retinopathy, nephropathy, and stroke10.2F10, F3, SERPINC1
23influenza10.2F2, F3, SERPINC1
24stroke, ischemic10.2F2, F3, F5, F7
25freiberg's disease10.2F2, F3, SERPINC1
26mixed hepatoblastoma10.2F2, F3, SERPINC1
27dmd-related dilated cardiomyopathy10.2F2, F3, SERPINC1
28spinal cord lipoma10.1F2, F3, SERPINC1
29midline cystocele10.1F2, F3, SERPINC1
30vascular erectile tumor10.1F2, F5, SERPINC1
31ductal carcinoma in situ10.1F2, F3, SERPINC1
32acrodysplasia with ossification abnormalities, short stature and fibular hypoplasia10.1F11, F3, F5, F9
33small intestinal l-cell glucagon-like peptide producing tumor10.1F2, VWF
34left-right axis malformations10.1F2, F5, SERPINC1
35lymphocytic colitis10.1F2, F5, SERPINC1
36hereditary alpha tryptasemia syndrome10.1F2, F3, SERPINC1
37central retinal artery occlusion10.1F2, F3, SERPINC1
38bullous skin disease10.1F2, F5, SERPINC1
39capillary hemangioma10.1F2, F3, SERPINC1
40neuroaxonal dystrophy10.1F2, F5, SERPINC1
41lynch syndrome10.1F2, F5, SERPINC1
42mixed epithelial tumor of ovary10.1F2, SERPINC1
43cryptosporidiosis10.1F2, F5, SERPINC1
44angular blepharoconjunctivitis10.1F2, F5, SERPINC1
45eagle syndrome10.1F2, F5, SERPINC1
46hemolytic-uremic syndrome10.1F2, F3, SERPINC1
47ophthalmia neonatorum10.1F2, F5, SERPINC1
48granulomatous hepatitis10.1F2, F3, SERPINC1
49peanut allergy10.1F2, SERPINC1
50pineal region meningioma10.1F10, F7, F9, VWF

Graphical network of the top 20 diseases related to Factor X Deficiency:



Diseases related to factor x deficiency

Symptoms & Phenotypes for Factor X Deficiency

About this section

Symptoms by clinical synopsis from OMIM:

227600

Clinical features from OMIM:

227600

Human phenotypes related to Factor X Deficiency:

 64 (show all 9)
id Description HPO Frequency HPO Source Accession
1 menorrhagia64 HP:0000132
2 gingival bleeding64 HP:0000225
3 epistaxis64 HP:0000421
4 intracranial hemorrhage64 HP:0002170
5 prolonged partial thromboplastin time64 HP:0003645
6 joint hemorrhage64 HP:0005261
7 prolonged prothrombin time64 HP:0008151
8 reduced factor x activity64 HP:0008321
9 intramuscular hematoma64 HP:0012233

MGI Mouse Phenotypes related to Factor X Deficiency according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.8F2, F3, F5, F9, SERPINC1, SSB
2MP:00053858.1F10, F11, F2, F3, F5, F7
3MP:00107687.5F10, F11, F2, F3, F5, F7
4MP:00053767.5F10, F11, F2, F3, F5, F7
5MP:00036317.1F11, F2, F3, F5, RBM8A, SERPINC1

Drugs & Therapeutics for Factor X Deficiency

About this section

Drugs for Factor X Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 327)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Lidocaineapproved, vet_approvedPhase 41317137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
2
Hyaluronic acidapproved, vet_approvedPhase 44699004-61-953477741, 24759
Synonyms:
Hyaluronan
Hyaluronate
Hyaluronic acid
Hylartil
Hyruan Plus
Luronit
 
Macronan
Mucoitin
Nutra-HAF
Q 5AQ
Sepracoat
Sepragel Sinus
Sofast
Synvisc
3
Epinephrineapproved, vet_approvedPhase 4, Phase 298551-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
4
Exenatideapproved, investigationalPhase 4296141758-74-915991534
Synonyms:
141732-76-5
141758-74-9
286014-72-0
335149-21-8
AC 2993
AC 2993 LAR
AC 2993A
AC-2993
AC002993
AC2993
AC2993a
Bydureon
Byetta
 
C074031
CHEBI:490990
CHEMBL414357
Ex4 peptide
Exenatide
Exenatide Synthetic
Exenatide synthetic
Exendin 4
Exendin 4 (Heloderma suspectum)
Exendin-4
Extendin-4
LY2148568
Synthetic exendin-4
UNII-9P1872D4OL
5
Ergocalciferolapproved, nutraceuticalPhase 4, Phase 2, Phase 3128150-14-65280793
Synonyms:
'Ergosterol irradiated'
(+)-Vitamin D2
(3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol
(3S,5Z,7E,14xi,17alpha,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3beta,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3beta,5Z,7e,22e)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
(5E,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
22-Tetraen 3beta 9,10,Secoergosta-5,7,10(19)-ol
31316-19-5
4-Methylene-3-[2-[tetrahydro-7a-methyl-1-(1,4,5-trimethyl-2-hexenyl)-4(3aH)-indanylidene]ethylidene]-Cyclohexanol
47768_SUPELCO
50-14-6
7489-18-1
7E677DC1-E1C4-4FC5-8F4A-BCE1857F7E87
8017-28-5
9,10,Secoergosta-5,7,10(19),22-tetraen 3.beta.-ol
9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3b-ol
95220_FLUKA
95220_SIGMA
AC-1355
AC1L1FIE
AC1NQXLH
AC1NS4DE
AC1NS9GI
AC1NSSVD
AC1NWAM3
AC1O5EDK
AC1O6WAM
ACon1_002187
Activated ergosterol
BPBio1_000418
BSPBio_000380
BSPBio_001974
Buco-D
C05441
C28H44O
CALCIFEROL IN A GELATIN MATRIX
CALCIFEROL, U.S.P.
CHEBI:28934
CHEMBL1536
CID11003810
CID3249
CID5280793
CID5315257
CID5353610
CID5356615
CID5702050
CID6432478
CID6536972
Calciferol
Calciferol (TN)
Calciferol (vitamin D2)
Calciferolum
Calciferon 2
Condacaps
Condocaps
Condol
Crtron
Crystallina
D-Arthin
D-Tracetten
D00187
DB00153
Daral
Davitamon D
Davitin
De-rat concentrate
Decaps
Dee-Osterol
Dee-Ron
Dee-Ronal
Dee-Roual
Deltalin
Deratol
Detalup
Diactol
Divit urto
Doral
Drisdol
Drisdol (TN)
E5750_SIGMA
EINECS 200-014-9
Ercalciol
Ergocalciferol
Ergocalciferol (D2)
Ergocalciferol (JP15/USP)
Ergocalciferol [INN:BAN:JAN]
Ergocalciferol oil
Ergocalciferol: Vitamin D
 
Ergocalciferolo
Ergocalciferolo [DCIT]
Ergocalciferols
Ergocalciferolum
Ergocalciferolum [INN-Latin]
Ergorone
Ergosterol activated
Ergosterol irradiated
Ergosterol, irradiated
Ertron
Fortodyl
Geltabs
Geltabs Vitamin D
HMS1920K20
HMS2091B19
HMS502I07
HSDB 819
Haliver
Hi-Deratol
Hyperkil
I05-0022
IDI1_000805
Infron
Irradiated ergosta-5,7,22-trien-3-beta-ol
Irradiated ergosta-5,7,22-trien-3.beta.-ol
Irradiated ergosta-5,7,22-trien-3beta-ol
Irradiated ergosterol
LMST03010001
LMST03010014
LS-3228
MEGxm0_000466
MLS001332467
MLS001332468
Metadee
Mina D2
MolPort-001-740-057
MolPort-001-793-930
MolPort-002-526-645
MolPort-003-666-178
MolPort-006-822-629
Mulsiferol
Mykostin
NCGC00142497-01
NCGC00179579-01
NCGC00179579-02
NSC 62792
NSC62792
Novovitamin-D
Oleovitamin D
Oleovitamin D, Synthetic
Oleovitamin D2
Osteil
Ostelin
Prestwick3_000420
Prestwick_554
Radiostol
Radstein
Radsterin
Rodine C
Rodinec
SMR000857106
SPECTRUM1500276
ST057150
STOCK1N-53397
Shock-ferol
Shock-ferol sterogyl
Sorex C.R
Sorex C.R.
Spectrum5_000666
Sterogyl
Synthetic Vitamin D
UNII-VS041H42XC
Uvesterol D
Uvesterol-D
VITAMIN D2
VITAMIN D2 WATER DISPERSABLE U.S.P.
VITAMIN_D2
Vigantol
Vio D
Vio-D
Viostdrol
Viosterol
Viosterol in Oil
Vitamin D2
Vitamin- D2
Vitamin-?D2
Vitamina D2
Vitavel-D
WLN: L56 FYTJ A1 BY1&1U1Y1&Y1&1 FU2U- BL6YYTJ AU1 DQ
ZINC04474571
ZINC04629876
beta-Ol
bmse000510
component of Geltabs Vitamin D
delta-Arthin
delta-Tracetten
ergocalciferol
vitamin d-2
6
Cholecalciferolapproved, nutraceuticalPhase 4, Phase 2, Phase 387567-97-06221, 10883523, 5280795
Synonyms:
()-Vitamin D3
(+)-Vitamin D3
(+)-vitamin D3
(1S,3Z)-3-[(2e)-2-[(1R,3AR,7as)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(3beta,Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
(3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(5E,7E)-9,10-Secocholesta-5,7,10-trien-3-ol
(5Z,7E)-(3S)-9,10-seco-5,7,10(19)-cholestatrien-3-ol
(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol
1406-16-2
25(OH)D
3-beta,Z,7E-9,10-Secocholestr-5,7,10(19)-trien-3-ol
47763_SUPELCO
57651-82-8
67-97-0
7-Dehydrocholesterol activated
7-Dehydrocholesterol, Activated
7-Dehydrocholesterol, irradiated
7-Dehydrocholestrol, activated
8024-19-9
8050-67-7
89193_FLUKA
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3-ol
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3beta-ol
9,10-Secocholesta-5(Z),7(E),10(19)-trien-3(.beta.)-ol
9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol
9,10-Secocholesta-5,7,10(19)-trien-3-ol
9,10-Secocholesta-5,7,10-trien-3-ol
AB1002422
AC-11697
AC1L1ECK
AC1L1M23
AC1LU7IZ
AC1NQXLN
AC1NR2UO
AC1NR2UR
AC1NR2UU
AC1NS4AJ
AC1NSHJX
AC1O5EOF
AC1O7GAV
AC1O7GQ3
AC1O8FEU
AC1O8PWJ
AC1OF2GI
AC1OF2GL
AC1OIEW5
AC1OIEWB
ACon1_001997
Activated 7-dehydrocholesterol
Arachitol
BPBio1_000460
BSPBio_000418
BSPBio_002408
Bio-0845
C05443
C1357_SIAL
C27H44O
C9756_SIGMA
C9774_SIAL
CAS-67-97-0
CC
CCRIS 5813
CCRIS 6286
CHEBI:283119
CHEBI:28940
CHEMBL1042
CHEMBL432780
CID10000117
CID10045875
CID10340013
CID10883523
CID10894379
CID11014566
CID11025493
CID11058152
CID11463269
CID1548921
CID2735
CID5280795
CID5283710
CID5283711
CID5283712
CID5353527
CID5363362
CID6221
CID6432644
CID6604201
CID6604662
CID6708595
CID6713938
CID6992015
CID6992016
CID7067439
CID7067440
CID7251172
CID7251174
CID9821465
Calciol
Cholecalciferol
Cholecalciferol (D3)
Cholecalciferol (JP15/USP)
Cholecalciferol D3
Cholecalciferol [USAN:BAN:JAN]
Cholecalciferol, D3
Cholecalciferolum
Colecalciferol
 
Colecalciferol (INN)
Colecalciferolo
Colecalciferolo [DCIT]
Colecalciferolum
Colecalciferolum [INN-Latin]
Colecalcipherol
D00188
D3-Vicotrat
D3-Vigantol
DB00169
Delsterol
Delta-D
Delta-D (TN)
Deparal
Devaron
DivK1c_006276
Duphafral D3 1000
EINECS 200-673-2
EINECS 215-797-2
EPA Pesticide Chemical Code 202901
Ebivit
FeraCol
Granuvit D3
HMS1569E20
HMS2092M12
HSDB 820
I05-0041
Irradiated 7-dehydrocholesterol
KBio1_001220
KBio2_001643
KBio2_004211
KBio2_006779
KBio3_001628
KBioGR_001602
KBioSS_001643
LMST03020001
LMST03020219
LMST03020220
LMST03020221
LS-1570
LS-825
LT00244775
MEGxm0_000458
Micro-dee
MolPort-001-740-051
MolPort-001-785-972
MolPort-003-666-021
MolPort-004-946-964
NCGC00016301-01
NCGC00017328-01
NCGC00091072-01
NCGC00142511-01
NCGC00159331-02
NCGC00159331-04
NCGC00178668-01
NCGC00179565-01
NCGC00179565-02
NEO Dohyfral D3
NSC 375571
NSC-375571
NSC375571
Oleovitamin D3
Prestwick0_000429
Prestwick1_000429
Prestwick2_000429
Prestwick3_000429
Prestwick_63
Provitamine
Provitina
Quintox
Rampage
Ricketon
SMP1_000068
SPBio_001298
SPBio_002357
SR-05000001559
SR-05000001559-3
ST057172
SpecPlus_000180
Spectrum2_001369
Spectrum3_000764
Spectrum4_001201
Spectrum_001163
TNP00266
Trivitan
UNII-1C6V77QF41
UPCMLD-DP152
UPCMLD-DP152:001
VITAMIN D
VITAMIN D3 POWDER
VITAMIN_D3
Vi-De3
Vi-de-3-hydrosol
VidDe-3-hydrosol
Videkhol
Vigantol
Vigorsan
Vitamin D-3
Vitamin D3
Vitamin D3 emulsifiable
Vitinc Dan-Dee-3
ZINC04474460
ZINC04492874
ZINC04492875
ZINC04492876
ZINC04492878
bmse000507
cholecalciferol
colecalciferolum
vitamin d-3
7
Menadioneapproved, nutraceuticalPhase 423958-27-54055
Synonyms:
03AAE1E9-B215-45AF-976C-91E61894A467
1,4-Naphthalenedione, 2-methyl-, radical ion(1-)
2-Methyl-1,4-Naphthalenedione
2-Methyl-1,4-naftochinon
2-Methyl-1,4-naftochinon [Czech]
2-Methyl-1,4-naphthalendione
2-Methyl-1,4-naphthalenedione
2-Methyl-1,4-naphthochinon
2-Methyl-1,4-naphthochinon [German]
2-Methyl-1,4-naphthodione
2-Methyl-1,4-naphthoquinone
2-Methylnaphthoquinone
2-methyl-1,4-naphthoquinone, 5
2-methylnaphthalene-1,4-dione
3-Methyl-1,4-naphthoquinone
34524-96-4
47775_SUPELCO
58-27-5
72060-21-0
AC1L1HBA
AC1Q2HB3
AI3-14700
AKOS004910447
ARONIS24154
Aquakay
Aquinone
BB_NC-2319
BIDD:ER0556
BPBio1_000592
BSPBio_000538
Bio1_000471
Bio1_000960
Bio1_001449
C05377
C11H8O2
CAS-58-27-5
CCRIS 6672
CHEBI:28869
CHEMBL590
CID4055
CPD-3766
D02335
DB00170
DivK1c_000080
DivK1c_006287
EINECS 200-372-6
HMS1569K20
HMS1921P06
HMS2092F12
HMS500D22
HSDB 3354
Hemodal
I14-2821
IDI1_000080
InChI=1/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H
Juva-K
K-Thrombyl
K-Vitan
KBio1_000080
KBio1_001231
KBio2_001708
KBio2_002527
KBio2_004276
KBio2_005095
KBio2_006844
KBio2_007663
KBio3_003005
KBioGR_000984
KBioGR_002527
KBioSS_001708
KBioSS_002535
Kaergona
Kanone
Kappaxan
Kappaxan (VAN)
Kappaxin
Kappaxin (TN)
Karcon
Kareon
Kativ-G
Kayklot
Kaykot
 
Kaynone
Kayquinone
Kipca
Kipca, oil soluble
Kipca-Oil Soluble
Klottone
Koaxin
Kolklot
LS-95653
LS-95654
M0373
M5625_SIGMA
M9429_SIGMA
MLS000069420
MLS001148443
MNQ
Memodol
Menadion
Menadione
Menadione (K3)
Menadione (USP)
Menadione [USAN:BAN]
Menadione semiquinone
Menadionum
Menaphthene
Menaphthon
Menaphthone
Menaphtone
Menaquinone
Menaquinone 0
Menaquinone O
Methyl-1,4-naphthalenedione
Methyl-1,4-naphthoquinone
Methylnaphthoquinone
Mitenon
Mitenone
MolPort-001-766-699
NCGC00016258-01
NCGC00094978-01
NCGC00094978-02
NCI60_003945
NCIMech_000105
NINDS_000080
NSC 4170
NSC4170
Panosine
Prestwick0_000459
Prestwick1_000459
Prestwick2_000459
Prestwick3_000459
Prestwick_313
Prokayvit
QTL1_000056
S1949_Selleck
SMR000059102
SMR000653532
SPBio_001267
SPBio_002477
SPECTRUM1502254
SpecPlus_000191
Spectrum2_001194
Spectrum4_000722
Spectrum5_001764
Spectrum_001228
Synkay
Thyloquinone
UNII-723JX6CXY5
Usaf ek-5185
VK3
Vicasol
Vitamin K 3
Vitamin K0
Vitamin K2
Vitamin K2(0)
Vitamin K3
Vitamin K3 : 2-Methyl-1,4-naphthoquinone
Vitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene
Vitamin-?K3
WLN: L66 BV EVJ C1
ZINC00001677
cMAP_000077
menadione
nchembio.109-comp5
8
Phytonadioneapproved, NutraceuticalPhase 423984-80-04812, 5284607
Synonyms:
.alpha.-Phylloquinone
1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl)-, radical ion(1-)
10485-69-5
11104-38-4
15973-57-6
2', 3'-trans-Vitamin K1
2',3'-trans-Vitamin K1
2-(3,7,11,15-Tetramethylhexadec-2-enyl)-3-methylnaphthalene-1,4-dione
2-METHYL-3-PHYTYL-14-NAPHTHOQUINONE
2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalened- ione
2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
2-Methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)-1,4-naphthoquinone
2-Methyl-3-[(2e)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone
2-Methyl-3-phythyl-1,4-naphthochinon
2-Methyl-3-phytyl-1,4-naphthochinon
2-Methyl-3-phytyl-1,4-naphthochinon [German]
2-Methyl-3-phytyl-1,4-naphthoquinone
2-methyl-3-(3,7,11,15-tetramethylhexadec-2-en-1-yl)naphthalene-1,4-dione
2-methyl-3-[(E)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
27696-10-2
3-Phytylmenadione
50926-17-5
84-80-0
AC1NQX34
AC1Q6B3J
AR-1E3503
Antihemorrhagic vitamin
Aqua mephyton
Aqua-Mephytin
Aquamephyton
C02059
C31H46O2
CID5280483
Combinal K1
D00148
DB01022
EINECS 201-564-2
EINECS 234-330-3
EINECS 279-833-9
Fitomenadiona
Fitomenadiona [INN-Spanish]
Fitomenadione
Fitomenadione [DCIT]
HSDB 3162
K-Ject
Kativ N
Kephton
 
Kinadion
Konakion
LS-94617
LT00452032
MLS001332659
MLS001332660
Mephyton
Mephyton (TN)
MolPort-001-785-978
Mono-Kay
Monodion
NCGC00159423-02
NSC 270681
NSC270681
P0642
Phyllochinon
Phyllochinon [German]
Phyllochinonum
Phylloquinone
Phylloquinone (8CI)
Phythyl-menadion
Phythyl-menadion (GERMAN)
Phytomenadione
Phytomenadione (INN)
Phytomenadionum
Phytomenadionum [INN-Latin]
Phytonadione
Phytonadione (JP15/USP)
Phytonadione [USAN:JAN]
Phytonadionum
Phytylmenadione
SMR000059144
ST075162
Synthex P
UNII-A034SE7857
VITAMIN K
VITAMIN K1
Vitamin K
Vitamin K 1
Vitamin K1
Vitamin K1 (TN)
Vitamin K1 (VAN)
Vitamin K1 (generic)
Vitamin K1(20)
alpha-Phylloquinone
phyllohydroquinone
phytonadione
trans-Phylloquinone
α-phylloquinone
9CoagulantsPhase 4, Phase 3, Phase 2, Phase 11500
10Pharmaceutical SolutionsPhase 4, Phase 3, Phase 2, Phase 18192
11Factor VIIIPhase 4, Phase 1, Phase 2316
12HormonesPhase 4, Phase 2, Phase 3, Phase 1, Early Phase 114415
13Hormone AntagonistsPhase 4, Phase 2, Phase 3, Phase 113180
14Bone Density Conservation AgentsPhase 4, Phase 2, Phase 33376
15AntimetabolitesPhase 4, Phase 3, Phase 1, Phase 212054
16Trace ElementsPhase 4, Phase 2, Phase 3, Phase 16001
17MicronutrientsPhase 4, Phase 2, Phase 3, Phase 16001
18ErgocalciferolsPhase 4, Phase 2, Phase 31281
19vitamin dPhase 4, Phase 2, Phase 31724
20Adjuvants, ImmunologicPhase 4, Phase 2, Phase 3, Phase 1, Early Phase 12554
21Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 2, Phase 3, Phase 113168
22VitaminsPhase 4, Phase 2, Phase 3, Phase 15282
23AnestheticsPhase 49596
24Anesthetics, LocalPhase 43492
25Epinephryl boratePhase 4, Phase 2985
26Immunoglobulin GPhase 4, Phase 3, Phase 2, Phase 1275
27Calcium, DietaryPhase 4, Phase 2, Phase 35713
28Hypoglycemic AgentsPhase 4, Phase 1, Phase 2, Early Phase 15896
29Rho(D) Immune GlobulinPhase 4, Phase 3, Phase 2326
30ViscosupplementsPhase 4390
31RacepinephrinePhase 4, Phase 2985
32Protective AgentsPhase 4, Phase 2, Phase 3, Phase 17443
33ImmunoglobulinsPhase 4, Phase 3, Phase 2, Phase 1, Early Phase 16394
34Vitamin K 2Phase 440
35HemostaticsPhase 4, Phase 3, Phase 21443
36Antifibrinolytic AgentsPhase 4484
37Immunoglobulins, IntravenousPhase 4, Phase 3, Phase 2333
38ThrombinPhase 4, Phase 3, Phase 2304
39Vitamin MK 7Phase 440
40Antiviral AgentsPhase 4, Phase 3, Phase 2, Phase 19967
41AnticoagulantsPhase 4, Phase 3, Phase 22623
42gamma-GlobulinsPhase 4, Phase 3, Phase 2326
43AntibodiesPhase 4, Phase 3, Phase 2, Phase 1, Early Phase 16394
44Hypolipidemic AgentsPhase 4, Phase 1, Phase 22785
45Lipid Regulating AgentsPhase 4, Phase 1, Phase 22766
46Hydroxymethylglutaryl-CoA Reductase InhibitorsPhase 41998
47Atorvastatin CalciumPhase 4760134523-03-8
48Anticholesteremic AgentsPhase 42025
49IncretinsPhase 41579
50CalciferolNutraceuticalPhase 4, Phase 2, Phase 31383

Interventional clinical trials:

(show top 50)    (show all 275)
idNameStatusNCT IDPhase
1Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis RegimensUnknown statusNCT02314325Phase 4
2Effect of Vitamin D on Metabolic Parameters in Patients With the Metabolic SyndromeUnknown statusNCT01237769Phase 4
3The Role Of FGF23, Klotho, And Sclerostin In Kidney Stone FormersUnknown statusNCT01526304Phase 4
4Efficacy and Safety of Prothromplex Total (Prothrombin Complex Concentrate) in Oral Anticoagulant ReversalCompletedNCT01159210Phase 4
5Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved?CompletedNCT02876354Phase 4
6GH and Cardiovascular Risk FactorsCompletedNCT01877512Phase 4
7Effect of Somatropin on Left Ventricular Mass in Growth Hormone Deficient Adult PatientsCompletedNCT01562834Phase 4
8Omacor and Cardiovascular Risk Factors in HIV Patients on HAART TreatmentCompletedNCT00296153Phase 4
9Magnesium and Metabolic SyndromeCompletedNCT00603499Phase 4
10Pharmacokinetics, Safety, and Tolerability of Subcutaneous GAMUNEX-C in Pediatric Subjects With Primary ImmunodeficiencyCompletedNCT01465958Phase 4
11A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary ImmunodeficiencyCompletedNCT01289847Phase 4
12Hyaluronic Acid in Papillary ReconstructionCompletedNCT02876276Phase 4
13Efficacy and Safety of Vivaglobin® in Previously Untreated Patients With Primary ImmunodeficiencyCompletedNCT00520494Phase 4
14Modulation of Monocyte Activation by Atorvastatin in HIV InfectionActive, not recruitingNCT01263938Phase 4
15SUbstition of PERioperative Albumin Deficiency DisordersNot yet recruitingNCT03167645Phase 4
16Pilot Study of Bydureon to Treat Diabetes in HIV-infected AdultsTerminatedNCT01791465Phase 4
17Safety and Efficacy in LPL-Deficient Subjects of AMT-011, an Adeno-Associated Viral Vector Expressing Human Lipoprotein Lipase [S447X]Unknown statusNCT01109498Phase 2, Phase 3
18T-Cell Depletion and Stem Cell Transplant for Immune Deficiencies and Histiocytic DisordersUnknown statusNCT00176826Phase 2, Phase 3
19A Study Investigating Treatment Factor X in People With Factor X DeficiencyCompletedNCT00930176Phase 3
20A Study to Investigate BPL's Factor X in the Prophylaxis of Bleeding in Children <12 YearsCompletedNCT01721681Phase 3
21Prothrombin Complex Concentrate for Anticoagulant ReversalCompletedNCT00168077Phase 3
22The Effect of Vitamin D and Calcium on Bone in Pediatric HIVCompletedNCT00724178Phase 2, Phase 3
23Efficacy and Safety of Human Lipoprotein Lipase (LPL)[S447X] Expressed by an Adeno-Associated Viral Vector in LPL-deficient SubjectsCompletedNCT00891306Phase 2, Phase 3
24Safety and Efficacy Study of Serostim® Human Immunodeficiency Virus-Associated Adipose Redistribution SyndromeCompletedNCT01077960Phase 3
25Bioequivalence Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Gammaplex® 10 and Gammaplex® 5% in Primary Immunodeficiency DiseasesCompletedNCT01963143Phase 3
26Treating Depression in Coronary Artery Disease With Omega-3 Fatty AcidsCompletedNCT00981383Phase 3
27Efficacy, Safety and Pharmacokinetics of Gammaplex in Primary Immunodeficiency Diseases.CompletedNCT00278954Phase 3
28Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement TherapyCompletedNCT00542997Phase 3
29Effectiveness of Paricalcitol in Reducing Parathyroid Hormone (PTH) Levels in X-linked Hypophosphatemic RicketsCompletedNCT00417612Phase 3
30Tolerability and Safety of Immune Globulin Subcutaneous Solution (IGSC) and rHuPH20 in PIDCompletedNCT01175213Phase 3
31Rapid Infusion of Immune Globulin Intravenous (Human) In Primary Immunodeficiency PatientsCompletedNCT00220766Phase 3
32The Efavirenz (EFV) Central Nervous System Exposure Sub-study of Encore1CompletedNCT01451333Phase 3
33WENBIT - Western Norway B Vitamin Intervention TrialCompletedNCT00354081Phase 3
34Study Comparing Lopinavir/Ritonavir (LPV/r) + Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) With a Nucleoside Sparing Regimen Consisting of Lopinavir/Ritonavir + Raltegravir (RAL)CompletedNCT00711009Phase 3
35Evaluation of a Lopinavir/Ritonavir Monotherapy vs a Triple Therapy as Maintenance Regimens in HIV-1 Infected PatientsCompletedNCT00946595Phase 2, Phase 3
36Study Comparing Efficacy and Safety of Darunavir Boosted With Ritonavir to HART With 2 NRTI and Darunavir Boosted With Ritonavir in HIV-1 Infected Patients ANRS136CompletedNCT00421551Phase 3
37BMS-Reyataz Study in Treatment in Naive Subjects to Compare the Efficacy and Safety Between Boosted Reyataz and Kaletra When in Combination With Fixed Dose TruvadaCompletedNCT00272779Phase 3
38Stem Cell Transplant for Inborn Errors of MetabolismCompletedNCT00176904Phase 2, Phase 3
39The Effect of Vitamin D Supplementation on Cardiovascular Risk FactorsRecruitingNCT02750293Phase 3
40Efficacy and Safety of KRN23 Versus Oral Phosphate and Active Vitamin D Treatment in Pediatric Patients With X Linked Hypophosphatemia (XLH)RecruitingNCT02915705Phase 3
41Effects of Interleukin-1 Beta on Low Testosterone Levels in Men With Obesity and Metabolic SyndromeRecruitingNCT02672592Phase 3
42DTaP-IPV-HB-PRP-T Combined Vaccine as a Primary Series and a 2nd Year of Life Booster in HIV-Exposed Infected and UninfectedRecruitingNCT02817451Phase 3
43Pivotal Phase 2b/3 ALVAC/Bivalent gp120/MF59 HIV Vaccine Prevention Safety and Efficacy Study in South AfricaRecruitingNCT02968849Phase 2, Phase 3
44Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic LeukaemiaRecruitingNCT01949129Phase 2, Phase 3
45Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH)Active, not recruitingNCT02537431Phase 3
46Study of KRN23 in Adults With X-linked Hypophosphatemia (XLH)Active, not recruitingNCT02526160Phase 3
47Pharmacokinetics (PK) and Safety of Subgam-VF in Primary Immunodeficiency DiseasesActive, not recruitingNCT01884311Phase 3
48Neo Adjuvant Chemotherapy in Triple Negative Breast CancerActive, not recruitingNCT01057069Phase 2, Phase 3
49Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon CancerActive, not recruitingNCT00217737Phase 3
50Trial of HDM/SCT Versus HDM + Bortezomib/SCT in AL AmyloidosisSuspendedNCT02489500Phase 3

Search NIH Clinical Center for Factor X Deficiency


Cochrane evidence based reviews: factor x deficiency

Genetic Tests for Factor X Deficiency

About this section

Genetic tests related to Factor X Deficiency:

id Genetic test Affiliating Genes
1 Factor X Deficiency27 24 F10

Anatomical Context for Factor X Deficiency

About this section

MalaCards organs/tissues related to Factor X Deficiency:

36
Liver, Skin, Lung, Testes, Myeloid

Publications for Factor X Deficiency

About this section

Articles related to Factor X Deficiency:

(show top 50)    (show all 221)
idTitleAuthorsYear
1
Factor X Deficiency with Heterozygous Mutations of Novel p.G435S and Known p.G244R in a Patient Presenting with Severe Umbilical Hemorrhage. (28302935)
2017
2
Successful Use of Four Factor-Prothrombin Complex Concentrate for Congenital Factor X Deficiency in the Setting of Neurosurgery. (27378481)
2016
3
Pharmacokinetics of a high-purity plasma-derived factor X concentrate in subjects with moderate or severe hereditary factor X deficiency. (26879266)
2016
4
A case of factor X deficiency in a Chihuahua dog. (27493287)
2016
5
Experience of a new high-purity factor X concentrate in subjects with hereditary factor X deficiency undergoing surgery. (27217097)
2016
6
Efficacy, safety and pharmacokinetics of a new high-purity factor X concentrate in subjects with hereditary factor X deficiency. (27197801)
2016
7
Homozygous missense mutation p.Val298Met of F10 gene causing hereditary coagulation factor X deficiency in a Chinese pedigree]. (27264807)
2016
8
Diagnostic Error of a Patient with Combined Inherited Factor VII and Factor X Deficiency due to Accidental Ingestion of a Diphacinone Rodenticide. (28164683)
2016
9
Spectrum of factor X gene mutations in Iranian patients with congenital factor X deficiency. (26891460)
2016
10
Prevalence of bleeding manifestations in 128 heterozygotes for Factor X deficiency, mainly for FX Friuli, matched vs 128 unaffected family members, during a long sequential observation period (23.5 years). (27124643)
2016
11
Synergistic effect of factor VII gene polymorphisms causing mild factor VII deficiency in a case of severe factor X deficiency. (26919454)
2016
12
Intracranial Hemorrhage as the First Manifestation of Severe Congenital Factor X Deficiency in a 20-Month-Old Male: Case Report and Review of the Literature. (27098186)
2016
13
A family with factor X deficiency from Argentina: a compound heterozygosis because of the combination of a new mutation (Gln138Arg) with an already known one (Glu350Lys). (27031279)
2016
14
Use of prothrombin complex concentrate for prophylaxis of bleeding in acquired factor X deficiency associated with light-chain amyloidosis. (27416580)
2016
15
Rare post-operative complications in a previously undiagnosed Congenital Factor X deficiency patient. (28028305)
2016
16
Frequency of the p.Gly262Asp mutation in congenital Factor X deficiency. (26222694)
2015
17
Molecular analysis of patients with severe congenital factor X deficiency: First report from north and northwest of Iran. (25984924)
2015
18
Autologous stem cell transplantation in immunoglobulin light chain amyloidosis with factor X deficiency. (26218969)
2015
19
A novel factor X gene mutation Val (GTC) 384Ala (GCC) in a Chinese family resulting in congenital factor X deficiency. (26309706)
2015
20
Neonatal onset of congenital factor X deficiency: a description of two novel mutations with 6-year follow-up. (26083982)
2015
21
Importance of Pharmacokinetic Studies in the Management of Acquired Factor X Deficiency. (25782416)
2015
22
Factor X deficiency associated with compound heterozygosity involving a novel missense mutation at codon 38 from Val (GTC) to Leu (CTC) in exon 2. (25803519)
2015
23
Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma. (26273448)
2015
24
Complex History of the Discovery and Characterization of Congenital Factor X Deficiency. (25875733)
2015
25
Near fatal spontaneous intraperitoneal bleeding: A rare manifestation in a congenital factor X deficiency carrier. (25810617)
2015
26
Surgical treatment for a paraplegic patient induced by congenital factor X deficiency. (26550274)
2015
27
Utility of factor X concentrate for the treatment of acquired factor X deficiency in systemic light-chain amyloidosis. (24786460)
2014
28
Acquired factor X deficiency developed four years after autologous transplantation in a patient with multiple myeloma associated with systemic AL amyloidosis. (24881922)
2014
29
Acquired factor X deficiency associated with atypical AL-amyloidosis. (25130122)
2014
30
Successful perioperative use of prothrombin complex concentrate in the treatment of acquired factor X deficiency in the setting of systemic light-chain (AL) amyloidosis. (25060940)
2014
31
Spontaneous spinal epidural hematoma in a patient with acquired Factor X deficiency secondary to systemic amyloid light-chain amyloidosis. (24974738)
2014
32
Circumcision in Patients with Congenital Factor X Deficiency. (24972549)
2014
33
Six novel missense mutations causing factor X deficiency and application of thrombin generation test. (23664564)
2013
34
Pharmacokinetics and prophylactic use of FEIBA in a child with severe congenital factor X deficiency and recurrent spontaneous intracranial haemorrhage: a case report. (23902347)
2013
35
Life-threatening bleeding tendency provoked by an acquired isolated factor X deficiency associated with respiratory infection. (23463452)
2013
36
Femur fracture in a woman with severe factor X deficiency - an experience using factor X concentrate in surgery. (24033840)
2013
37
Acquired factor X deficiency in systemic amyloidosis: management of two cases. (24033815)
2013
38
The clinical findings and prophylactic treatment in children with factor X deficiency. (23560890)
2013
39
Factor X deficiency: a rare cause of puberty menorrhagia. (22696092)
2013
40
Efficacy of prophylaxis and genotype-phenotype correlation in patients with severe Factor X deficiency in Iran. (21854511)
2012
41
Acquired, non-amyloid related factor X deficiency: review of the literature. (23437437)
2012
42
Factor X deficiency: an uncommon presentation of AL amyloidosis. (22651249)
2012
43
Successful liver transplantation for a child with life-threatening recurrent bleeding episodes due to congenital factor X deficiency: a case report. (22506295)
2012
44
Subgaleal hemorrhage in a neonate with factor X deficiency following a non-traumatic cesarean section. (22460599)
2012
45
Factor X deficiency and pregnancy: case report and counselling. (21943166)
2012
46
Factor X deficiency and pregnancy: preconception counselling and therapeutic options. (22151249)
2012
47
Hemorrhage because of amyloid-related factor X deficiency after insertion of Tenckhoff catheter. (22991017)
2012
48
Severe factor X deficiency in three unrelated Palestinian patients is caused by homozygosity for the mutation c302delG-correlation with thrombin generation and thromboelastometry. (22008904)
2011
49
Abscess in bilateral ovarian haematomas in a girl with factor X deficiency, necessitating oopherectomy. (21040235)
2011
50
Membranoproliferative glomerulonephritis and a rare bleeding disorder: Factor X deficiency. (20859684)
2011

Variations for Factor X Deficiency

About this section

UniProtKB/Swiss-Prot genetic disease variations for Factor X Deficiency:

70 (show all 26)
id Symbol AA change Variation ID SNP ID
1F10p.Glu47GlyVAR_065428rs121964943
2F10p.Gly51ValVAR_065429rs751782758
3F10p.Glu54GlyVAR_065430rs121964944
4F10p.Glu54LysVAR_065431rs121964939
5F10p.Glu72GlnVAR_065432rs121964945
6F10p.Glu91LysVAR_065433
7F10p.Cys149TyrVAR_065435
8F10p.Cys151TyrVAR_065436
9F10p.Gly289ArgVAR_065437rs121964946
10F10p.Glu304LysVAR_065438rs747292771
11F10p.Asp322AsnVAR_065439rs121964942
12F10p.Arg327TrpVAR_065440rs770119164
13F10p.Val338MetVAR_065441rs121964947
14F10p.Glu350LysVAR_065442rs372309538
15F10p.Thr358MetVAR_065443rs768222784
16F10p.Gly363SerVAR_065444
17F10p.Arg366CysVAR_065445rs104894392
18F10p.Ser374ProVAR_065446rs121964941
19F10p.Pro383SerVAR_065447rs121964940
20F10p.Cys390PheVAR_065448rs199778916
21F10p.Cys404ArgVAR_065449
22F10p.Gly406SerVAR_065450rs376163818
23F10p.Gly420ArgVAR_065451rs750759634
24F10p.Lys448AsnVAR_065452
25F10p.Val382AlaVAR_072751
26F10p.Gly421AspVAR_072752rs758726161

Clinvar genetic disease variations for Factor X Deficiency:

5 (show all 15)
id Gene Variation Type Significance SNP ID Assembly Location
1F10NM_ 000504.3(F10): c.1096C> T (p.Arg366Cys)SNVPathogenicrs104894392GRCh37Chr 13, 113803460: 113803460
2F10NM_ 000504.3(F10): c.813delC (p.Leu272Terfs)deletionPathogenicrs387906506GRCh37Chr 13, 113801758: 113801758
3F10F10, GLU14LYSSNVPathogenic
4F10F10, VAL298METundetermined variantPathogenic
5F10F10, PRO343SERSNVPathogenic
6F10F10, G-A, -20SNVPathogenic
7F10NM_ 000504.3(F10): c.859A> T (p.Arg287Trp)SNVPathogenicrs121964948GRCh37Chr 13, 113801804: 113801804
8F10F10, SER334PROundetermined variantPathogenic
9F10NM_ 000504.3(F10): c.424G> A (p.Glu142Lys)SNVPathogenicrs61753266GRCh37Chr 13, 113795286: 113795286
10F10F10, ASP282ASNundetermined variantPathogenic
11F10F10, GLU7GLYSNVPathogenic
12F10Factor X KetchikanSNVPathogenic
13F10F10, GLU32GLNSNVPathogenic
14F10; F7NM_ 000131.4(F7): c.1238G> A (p.Arg413Gln)SNVrisk factorrs6046GRCh37Chr 13, 113773159: 113773159
15F10F10, THR318METundetermined variantPathogenic

Expression for genes affiliated with Factor X Deficiency

About this section
Search GEO for disease gene expression data for Factor X Deficiency.

Pathways for genes affiliated with Factor X Deficiency

About this section

Pathways related to Factor X Deficiency according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5F10, F2, F7, F9
29.5F10, F2, F7, F9
3
Show member pathways
7.7F10, F11, F2, F3, F5, F7
4
Show member pathways
7.3F10, F11, F2, F3, F5, F7
5
Show member pathways
7.3F10, F11, F2, F3, F5, F7
6
Show member pathways
7.3F10, F11, F2, F3, F5, F7

GO Terms for genes affiliated with Factor X Deficiency

About this section

Cellular components related to Factor X Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intrinsic component of external side of plasma membraneGO:003123310.3F10, F3
2serine-type peptidase complexGO:190528610.0F3, F7
3Golgi lumenGO:00057969.9F10, F2, F7, F9
4platelet alpha granuleGO:00310919.7F5, VWF
5endoplasmic reticulum lumenGO:00057889.5F10, F2, F5, F7, F9, SERPINC1
6extracellular spaceGO:00056158.5F11, F2, F3, F5, F7, F9
7extracellular regionGO:00055768.0F10, F11, F2, F3, F5, F7

Biological processes related to Factor X Deficiency according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood coagulationGO:003019410.7F2, F7
2positive regulation of platelet-derived growth factor receptor signaling pathwayGO:001064110.7F3, F7
3positive regulation of positive chemotaxisGO:005092710.7F3, F7
4positive regulation of protein kinase B signalingGO:005189710.4F10, F3, F7
5response to vitamin KGO:003257110.3F5, F7
6platelet activationGO:003016810.2F2, F5, VWF
7peptidyl-glutamic acid carboxylationGO:001718710.2F10, F2, F7, F9
8ER to Golgi vesicle-mediated transportGO:00068889.9F10, F2, F5, F7, F9
9regulation of blood coagulationGO:00301939.8F11, F2, SERPINC1
10blood coagulation, intrinsic pathwayGO:00075979.8F10, F11, F2, F9, VWF
11blood coagulation, extrinsic pathwayGO:00075989.7F10, F3, F7, F9, TFPI
12signal peptide processingGO:00064659.5F10, F2, F7, F9
13proteolysisGO:00065089.4F10, F11, F2, F5, F7, F9
14blood coagulationGO:00075968.0F10, F11, F2, F3, F5, F7
15hemostasisGO:00075998.0F10, F11, F2, F3, F5, F7

Molecular functions related to Factor X Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:000820110.1F11, F2, SERPINC1
2protease bindingGO:00020209.9F3, SERPINC1, VWF
3peptidase activityGO:00082339.9F10, F11, F2, F7, F9
4serine-type endopeptidase activityGO:00042529.2F10, F11, F2, F3, F5, F7
5serine-type peptidase activityGO:00082369.2F10, F11, F2, F7, F9

Sources for Factor X Deficiency

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet