Factor Xiii Deficiency malady
Categories: Rare diseases, Blood diseases
Aliases & Descriptions for Factor Xiii Deficiency:
Orphanet epidemiological data:52
congenital factor xiii deficiency:
Inheritance: Autosomal recessive,Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy
Global: Rare diseases
Anatomical: Blood diseases
Rare haematological diseases
NIH Rare Diseases:46 Factor xiii deficiency is an extremely rare inherited blood disorder characterized by abnormal blood clotting that may result in abnormal bleeding. signs and symptoms occur as the result of a deficiency in the blood clotting factor 13, which is responsible for stabilizing the formation of a blood clot. in affected individuals, the blood fails to clot appropriately, resulting in poor wound healing. blood may seep into surrounding soft tissues, resulting in local pain and swelling. internal bleeding may occur; about 25 percent of affected individuals experience bleeding in the brain. fxiii deficiency is usually caused by mutations in the f13a1 gene, but mutations have also been found in the f13b gene. it is usually inherited in an autosomal recessive fashion. acquired forms have also been reported in association with liver failure, inflammatory bowel disease, and myeloid leukemia. last updated: 8/16/2011
MalaCards based summary: Factor Xiii Deficiency, also known as fibrin stabilizing factor deficiency, is related to myocardial infarction and rasa1-related disorders. An important gene associated with Factor Xiii Deficiency is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways are Dissolution of Fibrin Clot and Collagen biosynthesis and modifying enzymes. Affiliated tissues include liver, brain and myeloid, and related mouse phenotype homeostasis/metabolism.
Genetics Home Reference:24 Factor XIII deficiency is a rare bleeding disorder. Researchers have identified an inherited form and a less severe form that is acquired during a person's lifetime.
Wikipedia:69 Factor XIII deficiency occurs exceedingly rarely, causing a severe bleeding tendency. The incidence is... more...
Drugs for Factor Xiii Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):
Interventional clinical trials:(show all 17)
Search NIH Clinical Center for Factor Xiii Deficiency
MalaCards organs/tissues related to Factor Xiii Deficiency:34
Liver, Brain, Myeloid, Testes, Breast, Kidney, Spleen
Articles related to Factor Xiii Deficiency:(show top 50) (show all 230)
Search GEO for disease gene expression data for Factor Xiii Deficiency.
Pathways related to Factor Xiii Deficiency according to GeneCards Suite gene sharing:
Cellular components related to Factor Xiii Deficiency according to GeneCards Suite gene sharing:
Biological processes related to Factor Xiii Deficiency according to GeneCards Suite gene sharing:(show all 9)
Molecular functions related to Factor Xiii Deficiency according to GeneCards Suite gene sharing:
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet