MCID: FNT004
MIFTS: 39

Fainting malady

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Summaries for Fainting

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MedlinePlus:33 Fainting is a temporary loss of consciousness. if you're about to faint, you'll feel dizzy, lightheaded, or nauseous. your field of vision may "white out" or "black out." your skin may be cold and clammy. you lose muscle control at the same time, and may fall down. fainting usually happens when your blood pressure drops suddenly, causing a decrease in blood flow to your brain. it is more common in older people. some causes of fainting include heat or dehydration emotional distress standing up too quickly certain medicines drop in blood sugar heart problems when someone faints, make sure that the airway is clear and check for breathing. the person should stay lying down for 10-15 minutes. most people recover completely. fainting is usually nothing to worry about, but it can sometimes be a sign of a serious problem. if you faint, it's important to see your health care provider and find out why it happened.

MalaCards based summary: Fainting is related to syncope and factor xii deficiency. An important gene associated with Fainting is CHKB (choline kinase beta), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Complement and coagulation cascades. The compounds tetramethylpyrazine and abciximab have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and skin, and related mouse phenotype homeostasis/metabolism.

NINDS:43 Syncope is a medical term used to describe a temporary loss of consciousness due to the sudden decline of blood flow to the brain. Syncope is commonly called fainting or ?passing out.? If an individual is about to faint, he or she will feel dizzy, lightheaded, or nauseous and their field of vision may ?white out? or ?black out.?

Wikipedia:65 Syncope (/?s??k?pi/ SING-k?-pee), the medical term for fainting or passing out, is defined as a... more...

Aliases & Classifications for Fainting

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Fainting, Aliases & Descriptions:

Name: Fainting 43 33


Related Diseases for Fainting

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Diseases related to Fainting via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1syncope10.5
2factor xii deficiency10.4VWF
3postural orthostatic tachycardia syndrome10.3
4factor xi deficiency10.3F8
5long qt syndrome10.2
6chronic orthostatic intolerance10.2
7jervell-lange nielsen syndrome10.2
8brugada syndrome10.2
9cerebritis10.2
10aortic valve stenosis10.2
11acute myocardial infarction10.1VWF, CHKB
12multiple system atrophy10.1
13catecholaminergic polymorphic ventricular tachycardia10.1
14long qt syndrome 110.1
15multiple system atrophy with orthostatic hypotension10.1
16compartment syndrome10.1CHKB, F8
17hemarthrosis10.1F8, VWF
18intracranial thrombosis10.1VWF, F8
19noonan syndrome10.1CHKB, KCNH2
20hemorrhagic disease10.1VWF, F8
21blood platelet disease10.0F8, VWF
22von willebrand's disease10.0F8, VWF
23factor viii deficiency10.0VWF, F8
24afibrinogenemia10.0VWF, F8
25thrombotic thrombocytopenic purpura, acquired10.0VWF, F8
26bernard-soulier syndrome10.0VWF, F8
27glanzmann's thrombasthenia10.0VWF, F8
28antiphospholipid syndrome10.0VWF, F8
29thrombophilia10.0VWF, F8
30thromboembolism10.0F8, VWF
31hyperhomocysteinemia10.0VWF, F8
32myopathy10.0CHKB, KCNH2
33venous thrombosis10.0F8, VWF
34non-suppurative otitis media10.0CHKB, F8
35prion disease10.0F8, VWF
36hypersensitivity reaction type ii disease10.0VWF, F8
37congenital heart disease10.0VWF, F8
38thrombocytopenia10.0F8, VWF
39deficiency anemia10.0VWF, CHKB
40vascular disease9.9VWF, F8
41asthma9.9
42hepatitis9.9
43hypertension9.9
44peripheral t-cell lymphoma9.9
45pulmonary hypertension9.9
46sacrococcygeal teratoma9.9
47systemic mastocytosis9.9
48primary pulmonary hypertension9.9
49mumps9.9
50arrhythmogenic right ventricular cardiomyopathy9.9

Graphical network of the top 20 diseases related to Fainting:



Diseases related to fainting

Symptoms for Fainting

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Drugs & Therapeutics for Fainting

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Drug clinical trials:

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Genetic Tests for Fainting

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Anatomical Context for Fainting

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MalaCards organs/tissues related to Fainting:

32
Brain, Heart, Skin, Testes, Whole blood, Skeletal muscle, T cells, Pituitary

Animal Models for Fainting or affiliated genes

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MGI Mouse Phenotypes related to Fainting:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0F8, CHKB, KCNH2, VWF

Publications for Fainting

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Articles related to Fainting:

(show top 50)    (show all 185)
idTitleAuthorsYear
1
Fainting as an unusual presentation of a large inferior vena cava leiomyosarcoma. (24837084)
2014
2
Role of sympathetic nerve activity in the process of fainting. (25309444)
2014
3
Malignant cardioinhibitory vasovagal syncope - an uncommon cardiovascular complication of Roux-en-Y gastric bypass surgery: the fainting syndrome! (23063207)
2013
4
A 40-year-old man with recurrent fainting, hypotension, lower limb edema and oliguria with body weight gain and secondary erythrocytosis. (21948352)
2012
5
Case 2: 'I feel faint': An adolescent with recurrent dizziness and syncope. (23730166)
2012
6
Physiologic strategies to prevent fainting responses during or after whole blood donation. (21645008)
2011
7
Episode of fainting and tetany after an evaluation technique of the upper cervical region: a case report. (20724209)
2011
8
A 46-year-old woman with chin pain and a fainting spell. (20391493)
2010
9
Fainting with HIV. (20800149)
2010
10
Physiological correlates of applied tension may contribute to reduced fainting during medical procedures. (19730965)
2009
11
Fainting in classical art. (16730508)
2006
12
Blood-injury phobia with and without a history of fainting: disgust sensitivity does not explain the fainting response. (16554401)
2006
13
Evolution and fear-fainting. (16845485)
2006
14
Solving the mysteries of fainting. Why you may be at risk, and how you can protect yourself. (16193559)
2005
15
Fainting freshmen and sinking sophomores: cardiovascular issues of the adolescent. (15273492)
2004
16
Multiple life-threatening fainting episodes: fatal systemic mastocytosis. (14719479)
2003
17
Fainting induces an acute increase in the concentration of plasma factor VIII and von Willebrand factor. (12801845)
2003
18
Fainting in animals. (12955549)
2003
19
Long QT syndrome patients may faint due to neurocardiogenic syncope. (14753633)
2003
20
A fainting mechanic. (12147374)
2002
21
Fainting. When it spells trouble and when it doesn't. (14646918)
2002
22
Ask the doctor. I'm 78 years old. I've known for years that I have a narrowing of the aortic valve of my heart. My doctors are always asking me whether I have chest pain, fainting spells, or any other special symptoms. Until recently, the answer has been no. A few days ago, however, I was washing dishes in my kitchen, and I suddenly felt lightheaded and fell to the ground. I didn't black out, but I almost did. Now my doctor is saying that I should have my aortic valve replaced. Isn't this rather an extreme response to just one spell of lightheadedness? (11269241)
2001
23
Informed consent, and fainting fathers. (11412197)
2001
24
Intellect and somatic health: associations with hypochondriacal concerns, perceived threat and fainting. (11598431)
2001
25
The fainting patient. First and foremost, a meticulous evaluation. (11521616)
2000
26
Pacemakers promising for repeated fainting spells. (10198443)
1999
27
Antidepressants for fainting spells. (10445969)
1999
28
Postural hypotension. Faintness upon standing. (10892313)
1999
29
Sudden fainting in an elderly woman. (9793549)
1998
30
Expression patterns of the JEM-1 gene in normal and tumor cells: ubiquity contrasting with a faint, but retinoid-induced, mRNA expression in promyelocytic NB4 cells. (9823948)
1998
31
Variability of near-fainting responses in healthy 6-16-year-old subjects. (9337634)
1997
32
Hospitalization for fainting: high stakes, low yield. (9095018)
1997
33
Fainting precipitated by collapse-firing of venous baroreceptors. (8105220)
1993
34
The Mutilation Questionnaire as a predictor of blood/injury fear and fainting. (2256902)
1990
35
Emotional fainting and the psychophysiologic response to blood and injury: autonomic mechanisms and coping strategies. (3413272)
1988
36
The psychophysiological process of therapy in a case of injury-scene-elicited fainting. (4044863)
1985
37
Grand Rounds from Ohio State University: fainting. (7432113)
1980
38
Fainting and bromocriptine: Danger when motoring. (69848)
1977
39
Letter: Fainting during general anaesthesia in supine dental patients. (4414226)
1974
40
"The Fainting on the John"-syndrome. (5278114)
1971
41
The health questionnaire in general dental practice. 6. Epilepsy and fainting. (5287223)
1971
42
Fainting: a review of its mechanisms and a study in blood donors. (4864338)
1967
43
The common fainting attack: a danger in dental-chair anaesthesia. (5214679)
1965
44
THE COMMON FAINTING ATTACK; A DANGER IN DENTAL-CHAIR ANAESTHESIA. (14319205)
1965
45
FAINTING. (14064413)
1963
46
Post-operative fainting. Brain damage in patients propped up after operation. (13871931)
1962
47
Antidiuretic substances in human urine after haemorrhage, fainting, dehydration and acceleration. (13118534)
1953
48
After-cough fainting as a complication of bronchial asthma. (13076792)
1953
49
Hepatic blood flow and carbohydrate changes in man during fainting. (14898521)
1951
50
Fainting and shock. (20239280)
1947

Variations for Fainting

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Expression for genes affiliated with Fainting

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Expression patterns in normal tissues for genes affiliated with Fainting

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Pathways for genes affiliated with Fainting

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Pathways related to Fainting according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1F8, VWF
2
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.1F8, VWF
3
Show member pathways
9.1F8, VWF

Compounds for genes affiliated with Fainting

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Compounds related to Fainting according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1tetramethylpyrazine449.9CHKB, VWF
2abciximab44 1110.8VWF, CHKB
3guanidine44 24 1111.8VWF, CHKB
4clopidogrel44 50 24 1112.8VWF, CHKB
5saponins449.8KCNH2, CHKB
6clarithromycin44 1110.7CHKB, KCNH2
7diltiazem44 28 50 1112.7CHKB, KCNH2
8amiodarone44 50 28 1112.7KCNH2, CHKB
9raloxifene44 50 28 1112.6VWF, CHKB
10chlorpromazine28 44 50 1112.6KCNH2, CHKB
11recombinate449.6F8, VWF
12kogenate449.6F8, VWF
13tributylphosphate449.6VWF, F8
14halothane44 50 28 1112.6KCNH2, CHKB
15rfviii449.6F8, VWF
16phenytoin44 50 28 1112.6CHKB, KCNH2
17hydroxyethyl starch449.5VWF, F8
18tranexamic acid44 1110.5F8, VWF
19ristocetin449.5VWF, F8
20desmopressin44 61 28 1112.5F8, VWF
21guanidine hydrochloride449.4CHKB, VWF
22hirudin449.4VWF, F8
23fluvastatin44 50 28 1112.3CHKB, VWF
24ivig449.3F8, VWF
25warfarin44 50 24 1112.2F8, VWF
26adenylate449.1CHKB, KCNH2, VWF
27latex449.1CHKB, VWF, F8
28prednisolone44 28 1111.0CHKB, F8, VWF
29citrate449.0F8, CHKB, VWF
30agarose449.0CHKB, VWF, F8
31olanzapine44 50 28 24 1113.0KCNH2, CHKB
32aspirin44 50 28 2412.0CHKB, VWF, F8
33epinephrine44 24 1111.0F8, VWF, CHKB
34fibrinogen449.0VWF, CHKB, F8
35norepinephrine44 24 1111.0CHKB, F8, VWF
36testosterone44 61 24 1112.0VWF, KCNH2, CHKB
37cyclosporin a44 28 6111.0F8, VWF, CHKB
38glutamine449.0CHKB, VWF, F8
39lactate449.0F8, CHKB, VWF
40aspartate448.9F8, CHKB, VWF
41heparin44 28 24 1111.9F8, VWF, CHKB
42methionine448.9KCNH2, VWF, F8
43lysine448.9F8, CHKB, KCNH2
44cholesterol44 28 24 1111.7VWF, CHKB, F8
45steroid448.5F8, KCNH2, CHKB
46phospholipid448.4KCNH2, CHKB, F8, VWF
47creatinine448.4VWF, KCNH2, F8, CHKB
48arginine448.4F8, VWF, KCNH2, CHKB
49alanine448.4VWF, KCNH2, CHKB, F8
50calcium44 50 24 1111.2CHKB, KCNH2, F8, VWF

GO Terms for genes affiliated with Fainting

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Cellular components related to Fainting according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.1F8, VWF

Biological processes related to Fainting according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.1F8, VWF
2blood coagulation, intrinsic pathwayGO:0075979.0F8, VWF
3platelet degranulationGO:0025768.8F8, VWF

Products for genes affiliated with Fainting

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Sources for Fainting

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet