MCID: FNT004
MIFTS: 38

Fainting malady

Summaries for Fainting

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35MedlinePlus, 45NINDS, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Fainting is a temporary loss of consciousness. if you're about to faint, you'll feel dizzy, lightheaded, or nauseous. your field of vision may "white out" or "black out." your skin may be cold and clammy. you lose muscle control at the same time, and may fall down. fainting usually happens when your blood pressure drops suddenly, causing a decrease in blood flow to your brain. it is more common in older people. some causes of fainting include heat or dehydration emotional distress standing up too quickly certain medicines drop in blood sugar heart problems when someone faints, make sure that the airway is clear and check for breathing. the person should stay lying down for 10-15 minutes. most people recover completely. fainting is usually nothing to worry about, but it can sometimes be a sign of a serious problem. if you faint, it's important to see your health care provider and find out why it happened.

MalaCards: Fainting is related to syncope and long qt syndrome. An important gene associated with Fainting is CHKB (choline kinase beta), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Complement and coagulation cascades. The compounds tetramethylpyrazine and abciximab have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and skin, and related mouse phenotype homeostasis/metabolism.

NINDS:45 Syncope is a medical term used to describe a temporary loss of consciousness due to the sudden decline of blood flow to the brain. Syncope is commonly called fainting or ?passing out.? If an individual is about to faint, he or she will feel dizzy, lightheaded, or nauseous and their field of vision may ?white out? or ?black out.?

Wikipedia:66 Syncope (/?s??k?pi/ SING-k?-pee), the medical term for fainting or passing out, is defined as a... more...

Aliases & Classifications for Fainting

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45NINDS, 35MedlinePlus
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Aliases & Descriptions:

fainting 45 35


Related Diseases for Fainting

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18GeneCards, 19GeneDecks
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Diseases related to Fainting via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1syncope10.5
2long qt syndrome10.3
3postural orthostatic tachycardia syndrome10.3
4chronic orthostatic intolerance10.2
5cerebritis10.2
6aortic valve stenosis10.2
7factor xii deficiency10.1VWF
8jervell-lange nielsen syndrome10.1
9brugada syndrome10.1
10primary pulmonary hypertension10.1
11multiple system atrophy10.1
12multiple system atrophy with orthostatic hypotension10.1
13factor xi deficiency10.1F8
14acute myocardial infarction10.0CHKB, VWF
15compartment syndrome10.0CHKB, F8
16hemarthrosis10.0F8, VWF
17intracranial thrombosis10.0VWF, F8
18noonan syndrome10.0CHKB, KCNH2
19hemorrhagic disease10.0F8, VWF
20blood platelet disease10.0F8, VWF
21von willebrand's disease10.0VWF, F8
22afibrinogenemia10.0F8, VWF
23factor viii deficiency10.0F8, VWF
24thrombotic thrombocytopenic purpura, acquired10.0VWF, F8
25bernard-soulier syndrome10.0VWF, F8
26glanzmann's thrombasthenia10.0F8, VWF
27antiphospholipid syndrome10.0F8, VWF
28thrombophilia10.0VWF, F8
29thromboembolism10.0F8, VWF
30hyperhomocysteinemia10.0VWF, F8
31venous thrombosis10.0VWF, F8
32bronchitis10.0F8, CHKB
33prion disease10.0VWF, F8
34hypersensitivity reaction type ii disease10.0F8, VWF
35myopathy10.0CHKB, KCNH2
36congenital heart disease10.0VWF, F8
37thrombocytopenia10.0F8, VWF
38deficiency anemia10.0CHKB, VWF
39vascular disease10.0F8, VWF
40factor v leiden thrombophilia10.0F8, VWF
41coronary artery disease10.0CHKB, VWF
42pre-eclampsia10.0F8, VWF
43type 2 diabetes mellitus10.0F8, VWF
44hypothyroidism10.0F8, CHKB, VWF
45myocardial infarction10.0F8, CHKB, VWF
46mumps9.9
47arrhythmogenic right ventricular dysplasia9.9
48viral labyrinthitis9.9
49adenoma9.9
50asthma9.9

Graphical network of the top 20 diseases related to Fainting:



Diseases related to fainting

Symptoms for Fainting

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Drugs & Therapeutics for Fainting

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Fainting

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Anatomical Context for Fainting

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34MalaCards
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MalaCards organs/tissues related to Fainting:

34
Brain, Heart, Skin, Testes, Whole blood, Skeletal muscle, T cells, Pituitary

Animal Models for Fainting or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Fainting:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0F8, CHKB, KCNH2, VWF

Publications for Fainting

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53PubMed
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Articles related to Fainting:

(show top 50)    (show all 181)
idTitleAuthorsYear
1
Malignant cardioinhibitory vasovagal syncope - an uncommon cardiovascular complication of Roux-en-Y gastric bypass surgery: the fainting syndrome! (23063207)
2013
2
Long-Term Stability of Uveitis with Faint Anterior Chamber Flare Treated with Once-Daily Topical Ophthalmic Betamethasone. (24114448)
2013
3
A 40-year-old man with recurrent fainting, hypotension, lower limb edema and oliguria with body weight gain and secondary erythrocytosis. (21948352)
2012
4
Case 2: 'I feel faint': An adolescent with recurrent dizziness and syncope. (23730166)
2012
5
Does disgust increase parasympathetic activation in individuals with a history of fainting? A psychophysiological analysis of disgust stimuli with and without blood-injection-injury association. (23023164)
2012
6
Physiologic strategies to prevent fainting responses during or after whole blood donation. (21645008)
2011
7
Fainting, swooning, and syncope. (22132356)
2011
8
Episode of fainting and tetany after an evaluation technique of the upper cervical region: a case report. (20724209)
2011
9
A 46-year-old woman with chin pain and a fainting spell. (20391493)
2010
10
Fainting with HIV. (20800149)
2010
11
Physiological correlates of applied tension may contribute to reduced fainting during medical procedures. (19730965)
2009
12
Persistent fainting after implantation of a "curative" pacemaker. (19118314)
2009
13
Fainting in classical art. (16730508)
2006
14
Blood-injury phobia with and without a history of fainting: disgust sensitivity does not explain the fainting response. (16554401)
2006
15
Evolution and fear-fainting. (16845485)
2006
16
Fainting freshmen and sinking sophomores: cardiovascular issues of the adolescent. (15273492)
2004
17
Multiple life-threatening fainting episodes: fatal systemic mastocytosis. (14719479)
2003
18
Fainting induces an acute increase in the concentration of plasma factor VIII and von Willebrand factor. (12801845)
2003
19
Fainting in animals. (12955549)
2003
20
Long QT syndrome patients may faint due to neurocardiogenic syncope. (14753633)
2003
21
A fainting mechanic. (12147374)
2002
22
Fainting. When it spells trouble and when it doesn't. (14646918)
2002
23
Ask the doctor. I'm 78 years old. I've known for years that I have a narrowing of the aortic valve of my heart. My doctors are always asking me whether I have chest pain, fainting spells, or any other special symptoms. Until recently, the answer has been no. A few days ago, however, I was washing dishes in my kitchen, and I suddenly felt lightheaded and fell to the ground. I didn't black out, but I almost did. Now my doctor is saying that I should have my aortic valve replaced. Isn't this rather an extreme response to just one spell of lightheadedness? (11269241)
2001
24
Informed consent, and fainting fathers. (11412197)
2001
25
Intellect and somatic health: associations with hypochondriacal concerns, perceived threat and fainting. (11598431)
2001
26
The fainting patient. First and foremost, a meticulous evaluation. (11521616)
2000
27
Pacemakers promising for repeated fainting spells. (10198443)
1999
28
Antidepressants for fainting spells. (10445969)
1999
29
Postural hypotension. Faintness upon standing. (10892313)
1999
30
Sudden fainting in an elderly woman. (9793549)
1998
31
Expression patterns of the JEM-1 gene in normal and tumor cells: ubiquity contrasting with a faint, but retinoid-induced, mRNA expression in promyelocytic NB4 cells. (9823948)
1998
32
Variability of near-fainting responses in healthy 6-16-year-old subjects. (9337634)
1997
33
Hospitalization for fainting: high stakes, low yield. (9095018)
1997
34
Fainting precipitated by collapse-firing of venous baroreceptors. (8105220)
1993
35
The Mutilation Questionnaire as a predictor of blood/injury fear and fainting. (2256902)
1990
36
Emotional fainting and the psychophysiologic response to blood and injury: autonomic mechanisms and coping strategies. (3413272)
1988
37
The psychophysiological process of therapy in a case of injury-scene-elicited fainting. (4044863)
1985
38
Grand Rounds from Ohio State University: fainting. (7432113)
1980
39
Fainting and bromocriptine: Danger when motoring. (69848)
1977
40
Letter: Fainting during general anaesthesia in supine dental patients. (4414226)
1974
41
"The Fainting on the John"-syndrome. (5278114)
1971
42
The health questionnaire in general dental practice. 6. Epilepsy and fainting. (5287223)
1971
43
Fainting: a review of its mechanisms and a study in blood donors. (4864338)
1967
44
The common fainting attack: a danger in dental-chair anaesthesia. (5214679)
1965
45
THE COMMON FAINTING ATTACK; A DANGER IN DENTAL-CHAIR ANAESTHESIA. (14319205)
1965
46
FAINTING. (14064413)
1963
47
Post-operative fainting. Brain damage in patients propped up after operation. (13871931)
1962
48
After-cough fainting as a complication of bronchial asthma. (13076792)
1953
49
Hepatic blood flow and carbohydrate changes in man during fainting. (14898521)
1951
50
Fainting and shock. (20239280)
1947

Variations for Fainting

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Expression for genes affiliated with Fainting

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fainting

Search GEO for disease gene expression data for Fainting.

Pathways for genes affiliated with Fainting

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51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 55R&D Systems
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Pathways related to Fainting according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1F8, VWF
2
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.1F8, VWF
3
Show member pathways
9.1F8, VWF

Compounds for genes affiliated with Fainting

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Fainting according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1tetramethylpyrazine469.9CHKB, VWF
2abciximab46 1210.8CHKB, VWF
3guanidine46 25 1211.8CHKB, VWF
4saponins469.8CHKB, KCNH2
5clopidogrel46 52 25 1212.8CHKB, VWF
6clarithromycin46 1210.7CHKB, KCNH2
7amiodarone46 52 30 1212.7KCNH2, CHKB
8diltiazem46 30 52 1212.7KCNH2, CHKB
9raloxifene46 52 30 1212.7VWF, CHKB
10chlorpromazine30 46 52 1212.6CHKB, KCNH2
11recombinate469.6F8, VWF
12kogenate469.6F8, VWF
13tributylphosphate469.6F8, VWF
14rfviii469.6F8, VWF
15phenytoin46 52 30 1212.6KCNH2, CHKB
16hydroxyethyl starch469.5F8, VWF
17tranexamic acid46 1210.5VWF, F8
18halothane46 52 30 1212.5KCNH2, CHKB
19ristocetin469.5F8, VWF
20desmopressin46 62 30 1212.5F8, VWF
21guanidine hydrochloride469.4CHKB, VWF
22hirudin469.4F8, VWF
23fluvastatin46 52 30 1212.3CHKB, VWF
24ivig469.3VWF, F8
25warfarin46 52 25 1212.2F8, VWF
26adenylate469.1VWF, KCNH2, CHKB
27latex469.1VWF, CHKB, F8
28prednisolone46 30 1211.0F8, CHKB, VWF
29citrate469.0VWF, CHKB, F8
30agarose469.0F8, CHKB, VWF
31olanzapine46 52 30 25 1213.0CHKB, KCNH2
32aspirin46 52 30 2512.0VWF, CHKB, F8
33epinephrine46 25 1211.0F8, CHKB, VWF
34fibrinogen469.0F8, CHKB, VWF
35norepinephrine46 25 1211.0VWF, CHKB, F8
36testosterone46 62 25 1212.0CHKB, KCNH2, VWF
37cyclosporin a46 30 6211.0F8, CHKB, VWF
38glutamine469.0VWF, CHKB, F8
39lactate469.0VWF, CHKB, F8
40aspartate468.9VWF, CHKB, F8
41heparin46 30 25 1211.9F8, CHKB, VWF
42methionine468.9F8, KCNH2, VWF
43lysine468.9F8, CHKB, KCNH2
44cholesterol46 30 25 1211.7F8, CHKB, VWF
45steroid468.5KCNH2, CHKB, F8
46phospholipid468.4F8, CHKB, KCNH2, VWF
47creatinine468.4VWF, KCNH2, CHKB, F8
48arginine468.4VWF, KCNH2, CHKB, F8
49alanine468.4F8, CHKB, KCNH2, VWF
50calcium46 52 25 1211.2VWF, KCNH2, CHKB, F8

GO Terms for genes affiliated with Fainting

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17Gene Ontology
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Cellular components related to Fainting according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.1F8, VWF

Biological processes related to Fainting according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.1F8, VWF
2blood coagulation, intrinsic pathwayGO:0075979.0F8, VWF
3platelet degranulationGO:0025768.8F8, VWF

Products for genes affiliated with Fainting

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Sources for Fainting

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet