MCID: FNT004
MIFTS: 39

Fainting malady

Summaries for Fainting

Sources:
34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Fainting is a temporary loss of consciousness. if you're about to faint, you'll feel dizzy, lightheaded, or nauseous. your field of vision may "white out" or "black out." your skin may be cold and clammy. you lose muscle control at the same time, and may fall down. fainting usually happens when your blood pressure drops suddenly, causing a decrease in blood flow to your brain. it is more common in older people. some causes of fainting include heat or dehydration emotional distress standing up too quickly certain medicines drop in blood sugar heart problems when someone faints, make sure that the airway is clear and check for breathing. the person should stay lying down for 10-15 minutes. most people recover completely. fainting is usually nothing to worry about, but it can sometimes be a sign of a serious problem. if you faint, it's important to see your health care provider and find out why it happened.

MalaCards: Fainting is related to syncope and postural orthostatic tachycardia syndrome. An important gene associated with Fainting is KCNS1 (potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1), and among its related pathways are Ca-dependent events and Visual Cycle in Retinal Rods. The compounds shk-dap22 and xe 991 dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and heart.

NINDS:44 Syncope is a medical term used to describe a temporary loss of consciousness due to the sudden decline of blood flow to the brain. Syncope is commonly called fainting or ?passing out.? If an individual is about to faint, he or she will feel dizzy, lightheaded, or nauseous and their field of vision may ?white out? or ?black out.?

Wikipedia:64 Syncope (/ˈsɪŋkəpi/ SING-kə-pee), the medical term for fainting or passing out, is precisely... more...

Aliases & Classifications for Fainting

Sources:
44NINDS, 34MedlinePlus
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Aliases & Descriptions:

fainting 44 34


Related Diseases for Fainting

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Fainting:



Diseases related to fainting

Clinical Features for Fainting

Drugs & Therapeutics for Fainting

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Genetic Tests for Fainting

Anatomical Context for Fainting

Sources:
33MalaCards
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MalaCards organs/tissues related to Fainting:

33
Whole blood, Brain, Heart, Skeletal muscle, Skin

Animal Models for Fainting or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Fainting

Sources:
51PubMed
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Articles related to Fainting:

(show top 50)    (show all 168)
idTitleAuthorsYear
1
57-year-old man with flushing and fainting. (23639502)
2013
2
A pacemaker to prevent fainting. If your heart rate slows, a device can stop you from dropping. (23101130)
2012
3
Physiologic strategies to prevent fainting responses during or after whole blood donation. (21645008)
2011
4
Episode of fainting and tetany after an evaluation technique of the upper cervical region: a case report. (20724209)
2011
5
To avoid fainting: cross the legs and not the fingers. (20106794)
2010
6
Diagnostic tests for fainting found expensive, ineffective. The cheapest test for syncope--a postural blood pressure recording--may yield the most answers. (20120509)
2009
7
Behavioral avoidance and self-reported fainting symptoms in blood/injury fearful individuals: an experimental test of disgust domain specificity. (17920808)
2008
8
By the way, doctor. Do I need to go to the ER after fainting? (18697270)
2008
9
Familial aggregation of fainting in a case-control study of neurally mediated hypotension patients who present with unexplained chronic fatigue. (16920765)
2006
10
Disgust, anxiety and fainting symptoms associated with blood-injection-injury fears: a structural model. (16325112)
2006
11
Solving the mysteries of fainting. Why you may be at risk, and how you can protect yourself. (16193559)
2005
12
JAMA patient page. Fainting. (15353539)
2004
13
Fainting induces an acute increase in the concentration of plasma factor VIII and von Willebrand factor. (12801845)
2003
14
Fainting in animals. (12955549)
2003
15
Psychophysiologic effects of applied tension on the emotional fainting response to blood and injury. (12547376)
2003
16
Fainting. Why people pass out--and when it's a worry. (12763731)
2003
17
Cardiology patient page. Fainting. (12196326)
2002
18
Sudden fainting in an elderly woman. (9793549)
1998
19
The molecular genetics of the long QT syndrome: genes causing fainting and sudden death. (9509262)
1998
20
Near-infrared spectrophotometry determined brain oxygenation during fainting. (9597118)
1998
21
The role of disgust and fear in blood and injection--related fainting symptoms: a structural equation model. (9465441)
1997
22
Active vasodilation during fainting: a hypothesis revisited. (8902320)
1996
23
Fainting and convulsions in children: All is not epilepsy. (17588998)
1995
24
Mass fainting at medieval rock concerts. (7566046)
1995
25
Mass fainting at rock concerts. (7760886)
1995
26
Fainting precipitated by collapse-firing of venous baroreceptors. (8105220)
1993
27
Tilt table for the investigation of syncope: there is nothing simple about fainting. (1987215)
1991
28
Blood/injury fear, fainting and avoidance of medically-related situations: a family correspondence study. (2818416)
1989
29
Emotional fainting and the psychophysiologic response to blood and injury: autonomic mechanisms and coping strategies. (3413272)
1988
30
Fainting attacks and unusual T waves. (6430934)
1984
31
'The common fainting attack'. (6936034)
1981
32
The common fainting attack. (6933998)
1980
33
The health questionnaire in general dental practice. 6. Epilepsy and fainting. (5287223)
1971
34
Fainting and collapse in dental practice. (5258918)
1969
35
Fainting (syncope), with particular reference to breath-holding spells in young children. (4170503)
1968
36
Fainting: a review of its mechanisms and a study in blood donors. (4864338)
1967
37
The common fainting attack: a danger in dental-chair anaesthesia. (5214679)
1965
38
THE COMMON FAINTING ATTACK; A DANGER IN DENTAL-CHAIR ANAESTHESIA. (14319205)
1965
39
Post-operative fainting. Brain damage in patients propped up after operation. (13871931)
1962
40
Fainting. (13468038)
1957
41
Fainting and cerebral damage; a danger in patients kept upright during dental gas anaesthesia and after surgical operations. (13464101)
1957
42
The fainting child. (13245296)
1955
43
FAINTING. (13001190)
1952
44
Hepatic blood flow and carbohydrate changes in man during fainting. (14898521)
1951
45
Fainting and shock. (20239280)
1947
46
Value of electroencephalography in differential diagnosis of epilepsy and fainting. (20275056)
1946
47
Circulatory changes during fainting and coma caused by oxygen lack. (21027239)
1946
48
On the vasodilatation in human skeletal muscle during post-haemorrhagic fainting. (16991676)
1945
49
FAINTING AND FITS IN CARDIAC INFARCTION. (18609904)
1942
50
An Analysis of the Incidence of "Fainting" in 5,897 Unselected Blood Donors. (20784107)
1942

Genetic Variations for Fainting

Expression for genes affiliated with Fainting

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fainting

Search GEO for disease gene expression data for Fainting.

Pathways for genes affiliated with Fainting

Sources:
54Reactome, 52QIAGEN
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Compounds for genes affiliated with Fainting

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60Tocris Bioscience
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Compounds related to Fainting according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1shk-dap226010.6KCNG1, KCNS2, KCNF1, KCNS1, KCNV1
2xe 991 dihydrochloride6010.5KCNV1, KCNS1, KCNF1, KCNG1, KCNS2
3e-4031 dihydrochloride6010.5KCNG1, KCNS2, KCNF1, KCNS1, KCNV1
4jnj 3036010.5KCNG1, KCNS2, KCNF1, KCNS1, KCNV1
5suramin hexasodium salt6010.5GNAT2, GNAT1, GNAZ
6ica 1103816010.4KCNG1, KCNS2, KCNF1, KCNS1, KCNV1
7gallein6010.4GNAZ, GNAT1, GNAT2
8pertussis toxin6010.4GNAT2, GNAT1, GNAZ
9g-protein antagonist peptide6010.3GNAZ, GNAT1, GNAT2
108-bromo-cgmp, sodium salt6010.1GNAT2, GNAT1, GNAZ

GO Terms for genes affiliated with Fainting

Sources:
16Gene Ontology
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Cellular components related to Fainting according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extrinsic to internal side of plasma membraneGO:03123410.5GNAZ, GNAT1, GNAT2
2voltage-gated potassium channel complexGO:00807610.5KCNG1, KCNS2, KCNF1, KCNS1, KCNV1
3heterotrimeric G-protein complexGO:00583410.5GNAT2, GNAT1, GNAZ
4photoreceptor outer segmentGO:00175010.4GNAT1, GNAT2
5photoreceptor outer segment membraneGO:04262210.3GNAT2, GNAT1
6plasma membraneGO:00588610.2KCNV1, KCNS1, KCNF1, KCNS2, KCNG1, GNAT2
7photoreceptor inner segmentGO:00191710.1GNAT1, GNAT2

Biological processes related to Fainting according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1potassium ion transportGO:00681310.5KCNV1, KCNS1, KCNF1, KCNG1
2protein homooligomerizationGO:05126010.5KCNG1, KCNS2, KCNF1, KCNS1, KCNV1
3adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.5GNAZ, GNAT1, GNAT2
4response to light intensityGO:00964210.5GNAT2, GNAT1
5sulfate transportGO:00827210.4SLC26A1, SLC26A10
6detection of chemical stimulus involved in sensory perception of bitter tasteGO:00158010.3GNAT2, GNAT1
7synaptic transmissionGO:00726810.3KCNG1, KCNS2, KCNF1, KCNS1, KCNV1
8detection of light stimulus involved in visual perceptionGO:05090810.1GNAT1, GNAT2

Molecular functions related to Fainting according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein beta/gamma-subunit complex bindingGO:03168310.5GNAZ, GNAT1, GNAT2
2delayed rectifier potassium channel activityGO:00525110.4KCNG1, KCNS2, KCNF1, KCNS1, KCNV1
3sulfate transmembrane transporter activityGO:01511610.4SLC26A10, SLC26A1
4potassium channel regulator activityGO:01545910.4KCNS1, KCNV1
5G-protein coupled receptor bindingGO:00166410.3GNAT1, GNAT2
6potassium channel activityGO:00526710.1KCNG1, KCNF1

Products for genes affiliated with Fainting

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Sources for Fainting

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet