MCID: FNT004
MIFTS: 38

Fainting malady

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Summaries for Fainting

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34MedlinePlus, 44NINDS, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Fainting is a temporary loss of consciousness. if you're about to faint, you'll feel dizzy, lightheaded, or nauseous. your field of vision may "white out" or "black out." your skin may be cold and clammy. you lose muscle control at the same time, and may fall down. fainting usually happens when your blood pressure drops suddenly, causing a decrease in blood flow to your brain. it is more common in older people. some causes of fainting include heat or dehydration emotional distress standing up too quickly certain medicines drop in blood sugar heart problems when someone faints, make sure that the airway is clear and check for breathing. the person should stay lying down for 10-15 minutes. most people recover completely. fainting is usually nothing to worry about, but it can sometimes be a sign of a serious problem. if you faint, it's important to see your health care provider and find out why it happened.

MalaCards: Fainting is related to syncope and long qt syndrome. An important gene associated with Fainting is CHKB (choline kinase beta), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Complement and coagulation cascades. The compounds tetramethylpyrazine and abciximab have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and skin, and related mouse phenotype homeostasis/metabolism.

NINDS:44 Syncope is a medical term used to describe a temporary loss of consciousness due to the sudden decline of blood flow to the brain. Syncope is commonly called fainting or ?passing out.? If an individual is about to faint, he or she will feel dizzy, lightheaded, or nauseous and their field of vision may ?white out? or ?black out.?

Wikipedia:65 Syncope (/?s??k?pi/ SING-k?-pee), the medical term for fainting or passing out, is defined as a... more...

Aliases & Classifications for Fainting

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44NINDS, 34MedlinePlus
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Aliases & Descriptions:

fainting 44 34


Related Diseases for Fainting

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17GeneCards, 18GeneDecks
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Diseases related to Fainting via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1syncope10.5
2long qt syndrome10.3
3postural orthostatic tachycardia syndrome10.3
4chronic orthostatic intolerance10.2
5cerebritis10.2
6aortic valve stenosis10.2
7factor xii deficiency10.1VWF
8jervell-lange nielsen syndrome10.1
9brugada syndrome10.1
10primary pulmonary hypertension10.1
11multiple system atrophy10.1
12multiple system atrophy with orthostatic hypotension10.1
13factor xi deficiency10.1F8
14acute myocardial infarction10.0CHKB, VWF
15compartment syndrome10.0CHKB, F8
16hemarthrosis10.0F8, VWF
17intracranial thrombosis10.0VWF, F8
18noonan syndrome10.0CHKB, KCNH2
19hemorrhagic disease10.0F8, VWF
20blood platelet disease10.0F8, VWF
21von willebrand's disease10.0VWF, F8
22afibrinogenemia10.0F8, VWF
23factor viii deficiency10.0F8, VWF
24thrombotic thrombocytopenic purpura, acquired10.0VWF, F8
25bernard-soulier syndrome10.0VWF, F8
26glanzmann's thrombasthenia10.0F8, VWF
27antiphospholipid syndrome10.0F8, VWF
28thrombophilia10.0VWF, F8
29thromboembolism10.0F8, VWF
30hyperhomocysteinemia10.0VWF, F8
31venous thrombosis10.0VWF, F8
32bronchitis10.0F8, CHKB
33prion disease10.0VWF, F8
34hypersensitivity reaction type ii disease10.0F8, VWF
35myopathy10.0CHKB, KCNH2
36congenital heart disease10.0VWF, F8
37thrombocytopenia10.0F8, VWF
38deficiency anemia10.0CHKB, VWF
39vascular disease10.0F8, VWF
40factor v leiden thrombophilia10.0F8, VWF
41coronary artery disease10.0CHKB, VWF
42pre-eclampsia10.0F8, VWF
43type 2 diabetes mellitus10.0F8, VWF
44hypothyroidism10.0F8, CHKB, VWF
45myocardial infarction10.0F8, CHKB, VWF
46mumps9.9
47arrhythmogenic right ventricular dysplasia9.9
48viral labyrinthitis9.9
49adenoma9.9
50asthma9.9

Graphical network of the top 20 diseases related to Fainting:



Diseases related to fainting

Symptoms for Fainting

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Drugs & Therapeutics for Fainting

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Fainting

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Anatomical Context for Fainting

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33MalaCards
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MalaCards organs/tissues related to Fainting:

33
Brain, Heart, Skin, Testes, Whole blood, Skeletal muscle, T cells, Pituitary

Animal Models for Fainting or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Fainting:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0F8, CHKB, KCNH2, VWF

Publications for Fainting

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52PubMed
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Articles related to Fainting:

(show top 50)    (show all 181)
idTitleAuthorsYear
1
Malignant cardioinhibitory vasovagal syncope - an uncommon cardiovascular complication of Roux-en-Y gastric bypass surgery: the fainting syndrome! (23063207)
2013
2
Long-Term Stability of Uveitis with Faint Anterior Chamber Flare Treated with Once-Daily Topical Ophthalmic Betamethasone. (24114448)
2013
3
A 40-year-old man with recurrent fainting, hypotension, lower limb edema and oliguria with body weight gain and secondary erythrocytosis. (21948352)
2012
4
Case 2: 'I feel faint': An adolescent with recurrent dizziness and syncope. (23730166)
2012
5
Does disgust increase parasympathetic activation in individuals with a history of fainting? A psychophysiological analysis of disgust stimuli with and without blood-injection-injury association. (23023164)
2012
6
Physiologic strategies to prevent fainting responses during or after whole blood donation. (21645008)
2011
7
Fainting, swooning, and syncope. (22132356)
2011
8
Episode of fainting and tetany after an evaluation technique of the upper cervical region: a case report. (20724209)
2011
9
A 46-year-old woman with chin pain and a fainting spell. (20391493)
2010
10
Fainting with HIV. (20800149)
2010
11
Physiological correlates of applied tension may contribute to reduced fainting during medical procedures. (19730965)
2009
12
Persistent fainting after implantation of a "curative" pacemaker. (19118314)
2009
13
Fainting in classical art. (16730508)
2006
14
Blood-injury phobia with and without a history of fainting: disgust sensitivity does not explain the fainting response. (16554401)
2006
15
Evolution and fear-fainting. (16845485)
2006
16
Fainting freshmen and sinking sophomores: cardiovascular issues of the adolescent. (15273492)
2004
17
Multiple life-threatening fainting episodes: fatal systemic mastocytosis. (14719479)
2003
18
Fainting induces an acute increase in the concentration of plasma factor VIII and von Willebrand factor. (12801845)
2003
19
Fainting in animals. (12955549)
2003
20
Long QT syndrome patients may faint due to neurocardiogenic syncope. (14753633)
2003
21
A fainting mechanic. (12147374)
2002
22
Fainting. When it spells trouble and when it doesn't. (14646918)
2002
23
Ask the doctor. I'm 78 years old. I've known for years that I have a narrowing of the aortic valve of my heart. My doctors are always asking me whether I have chest pain, fainting spells, or any other special symptoms. Until recently, the answer has been no. A few days ago, however, I was washing dishes in my kitchen, and I suddenly felt lightheaded and fell to the ground. I didn't black out, but I almost did. Now my doctor is saying that I should have my aortic valve replaced. Isn't this rather an extreme response to just one spell of lightheadedness? (11269241)
2001
24
Informed consent, and fainting fathers. (11412197)
2001
25
Intellect and somatic health: associations with hypochondriacal concerns, perceived threat and fainting. (11598431)
2001
26
The fainting patient. First and foremost, a meticulous evaluation. (11521616)
2000
27
Pacemakers promising for repeated fainting spells. (10198443)
1999
28
Antidepressants for fainting spells. (10445969)
1999
29
Postural hypotension. Faintness upon standing. (10892313)
1999
30
Sudden fainting in an elderly woman. (9793549)
1998
31
Expression patterns of the JEM-1 gene in normal and tumor cells: ubiquity contrasting with a faint, but retinoid-induced, mRNA expression in promyelocytic NB4 cells. (9823948)
1998
32
Variability of near-fainting responses in healthy 6-16-year-old subjects. (9337634)
1997
33
Hospitalization for fainting: high stakes, low yield. (9095018)
1997
34
Fainting precipitated by collapse-firing of venous baroreceptors. (8105220)
1993
35
The Mutilation Questionnaire as a predictor of blood/injury fear and fainting. (2256902)
1990
36
Emotional fainting and the psychophysiologic response to blood and injury: autonomic mechanisms and coping strategies. (3413272)
1988
37
The psychophysiological process of therapy in a case of injury-scene-elicited fainting. (4044863)
1985
38
Grand Rounds from Ohio State University: fainting. (7432113)
1980
39
Fainting and bromocriptine: Danger when motoring. (69848)
1977
40
Letter: Fainting during general anaesthesia in supine dental patients. (4414226)
1974
41
"The Fainting on the John"-syndrome. (5278114)
1971
42
The health questionnaire in general dental practice. 6. Epilepsy and fainting. (5287223)
1971
43
Fainting: a review of its mechanisms and a study in blood donors. (4864338)
1967
44
The common fainting attack: a danger in dental-chair anaesthesia. (5214679)
1965
45
THE COMMON FAINTING ATTACK; A DANGER IN DENTAL-CHAIR ANAESTHESIA. (14319205)
1965
46
FAINTING. (14064413)
1963
47
Post-operative fainting. Brain damage in patients propped up after operation. (13871931)
1962
48
After-cough fainting as a complication of bronchial asthma. (13076792)
1953
49
Hepatic blood flow and carbohydrate changes in man during fainting. (14898521)
1951
50
Fainting and shock. (20239280)
1947

Variations for Fainting

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Expression for genes affiliated with Fainting

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fainting

Search GEO for disease gene expression data for Fainting.

Pathways for genes affiliated with Fainting

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50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 54R&D Systems
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Pathways related to Fainting according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1F8, VWF
2
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.1F8, VWF
3
Show member pathways
9.1F8, VWF

Compounds for genes affiliated with Fainting

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45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Fainting according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1tetramethylpyrazine459.9CHKB, VWF
2abciximab45 1110.8CHKB, VWF
3guanidine45 24 1111.8CHKB, VWF
4saponins459.8CHKB, KCNH2
5clopidogrel45 51 24 1112.8CHKB, VWF
6clarithromycin45 1110.7CHKB, KCNH2
7amiodarone45 51 29 1112.7KCNH2, CHKB
8diltiazem45 29 51 1112.7KCNH2, CHKB
9raloxifene45 51 29 1112.7VWF, CHKB
10chlorpromazine29 45 51 1112.6CHKB, KCNH2
11recombinate459.6F8, VWF
12kogenate459.6F8, VWF
13tributylphosphate459.6F8, VWF
14rfviii459.6F8, VWF
15phenytoin45 51 29 1112.6KCNH2, CHKB
16hydroxyethyl starch459.5F8, VWF
17tranexamic acid45 1110.5VWF, F8
18halothane45 51 29 1112.5KCNH2, CHKB
19ristocetin459.5F8, VWF
20desmopressin45 61 29 1112.5F8, VWF
21guanidine hydrochloride459.4CHKB, VWF
22hirudin459.4F8, VWF
23fluvastatin45 51 29 1112.3CHKB, VWF
24ivig459.3VWF, F8
25warfarin45 51 24 1112.2F8, VWF
26adenylate459.1VWF, KCNH2, CHKB
27latex459.1VWF, CHKB, F8
28prednisolone45 29 1111.0F8, CHKB, VWF
29citrate459.0VWF, CHKB, F8
30agarose459.0F8, CHKB, VWF
31olanzapine45 51 29 24 1113.0CHKB, KCNH2
32aspirin45 51 29 2412.0VWF, CHKB, F8
33epinephrine45 24 1111.0F8, CHKB, VWF
34fibrinogen459.0F8, CHKB, VWF
35norepinephrine45 24 1111.0VWF, CHKB, F8
36testosterone45 61 24 1112.0CHKB, KCNH2, VWF
37cyclosporin a45 29 6111.0F8, CHKB, VWF
38glutamine459.0VWF, CHKB, F8
39lactate459.0VWF, CHKB, F8
40aspartate458.9VWF, CHKB, F8
41heparin45 29 24 1111.9F8, CHKB, VWF
42methionine458.9F8, KCNH2, VWF
43lysine458.9F8, CHKB, KCNH2
44cholesterol45 29 24 1111.7F8, CHKB, VWF
45steroid458.5KCNH2, CHKB, F8
46phospholipid458.4F8, CHKB, KCNH2, VWF
47creatinine458.4VWF, KCNH2, CHKB, F8
48arginine458.4VWF, KCNH2, CHKB, F8
49alanine458.4F8, CHKB, KCNH2, VWF
50calcium45 51 24 1111.2VWF, KCNH2, CHKB, F8

GO Terms for genes affiliated with Fainting

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16Gene Ontology
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Cellular components related to Fainting according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.1F8, VWF

Biological processes related to Fainting according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.1F8, VWF
2blood coagulation, intrinsic pathwayGO:0075979.0F8, VWF
3platelet degranulationGO:0025768.8F8, VWF

Products for genes affiliated with Fainting

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Sources for Fainting

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet