Fallopian Tube Cancer malady

Disease Ontology: A female reproductive organ cancer that is located in fallopian tube.⁶

MalaCards: Fallopian Tube Cancer, also known as malignant tumor of fallopian tube (disorder), is related to fallopian tube carcinoma and ovarian cancer. An important gene associated with Fallopian Tube Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are Fanconis Anaemia Pathway and DNA damage Role of Brca1 and Brca2 in DNA repair. The drugs prednisone and prednisolone tebutate and the compounds etoposide and vinorelbine have been mentioned in the context of this disorder. Affiliated tissues include fallopian tube and breast, and related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Aliases & Descriptions:

fallopian tube cancer 6 malignant tumor of fallopian tube (disorder) 6 neoplasm of fallopian tube (disorder) 6 malignant neoplasm of uterine tube 6 malignant tumour of fallopian tube 6 tumor, fallopian tube, malignant 6

tumor of the fallopian tube 6 fallopian tube neoplasms 43 fallopian tube carcinoma 43 fallopian tube neoplasm 6 malignant neoplasms 43 neoplasms 43

Diseases related to fallopian tube cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 935)

id	Related Disease	Score	Top Affiliating Genes
1	fallopian tube carcinoma	32.2	BRCA1, BRCA2, ERBB2
2	ovarian cancer	29.3	BRCA2, BRCA1
3	breast cancer	28.7	ERBB2, BRCA2, BRCA1
4	pancreatic ductal carcinoma	28.6	BRCA1, BRCA2, ERBB2
5	pancreatic cancer	28.6	ERBB2, BRCA2, BRCA1
6	peritonitis	28.5	ERBB2, BRCA2, BRCA1
7	prostate carcinoma	27.9	BRCA2, ERBB2
8	sarcoma	27.6	BRCA1, BRCA2, ERBB2
9	male breast cancer	27.3	BRCA1, BRCA2, ERBB2
10	stomach carcinoma	27.3	BRCA1, BRCA2, ERBB2
11	hematologic cancer	27.3	BRCA1, BRCA2
12	lynch syndrome	27.2	BRCA1, BRCA2
13	angiosarcoma	26.9	BRCA1, ERBB2
14	leiomyoma	26.8	BRCA1, BRCA2, ERBB2
15	pleomorphic adenoma	26.4	ERBB2, BRCA1
16	laryngitis	26.4	ERBB2, BRCA2, BRCA1
17	breast carcinoma	26.3	ERBB2, BRCA2, BRCA1
18	hodgkin's lymphoma	26.3	BRCA2, BRCA1
19	multiple endocrine neoplasia	26.3	BRCA2, BRCA1
20	wilms tumor	26.0	ERBB2, BRCA2, BRCA1
21	familial pancreatic cancer	26.0	ERBB2, BRCA2, BRCA1
22	ductal carcinoma in situ	25.9	BRCA1, BRCA2, ERBB2
23	oligodendroglioma	25.9	BRCA2, ERBB2
24	thyroid carcinoma	25.8	BRCA1, BRCA2, ERBB2
25	dna topoisomerase ii	25.8	BRCA1, ERBB2
26	retinoblastoma	25.8	ERBB2, BRCA2, BRCA1
27	cervical cancer	25.6	BRCA1, BRCA2, ERBB2
28	glioblastoma	25.6	ERBB2, BRCA2, BRCA1
29	ovarian carcinoma	25.2	BRCA1, BRCA2, ERBB2
30	small cell carcinoma	24.7	BRCA1, BRCA2, ERBB2
31	epithelial ovarian cancer	24.6	BRCA1, BRCA2, ERBB2
32	clear cell adenocarcinoma	24.4	ERBB2, BRCA1
33	nonencapsulated sclerosing carcinoma	24.1	ERBB2, BRCA2
34	von hippel-lindau disease	24.0	BRCA2, BRCA1
35	oral cancer	23.3	ERBB2, BRCA2, BRCA1
36	astrocytoma	23.2	BRCA1, BRCA2, ERBB2
37	female breast carcinoma	12.8	BRCA1, ERBB2
38	cribriform carcinoma	12.8	BRCA1, ERBB2
39	estrogen-receptor positive breast cancer	12.7	BRCA1, ERBB2
40	thyroid medullary carcinoma	12.7	BRCA1, ERBB2
41	leukoplakia	12.7	BRCA1, ERBB2
42	bile duct cancer	12.6	ERBB2, BRCA2
43	laryngeal cancer	12.6	BRCA1, ERBB2
44	female breast cancer	12.5	ERBB2, BRCA2
45	brca1 and brca2 hereditary breast and ovarian cancer	12.5	BRCA2, BRCA1
46	hereditary breast ovarian cancer	12.5	BRCA2, BRCA1
47	li-fraumeni syndrome	12.5	BRCA2, BRCA1
48	cowden disease	12.5	BRCA1, BRCA2
49	mutagen sensitivity	12.5	BRCA1, BRCA2
50	dysgerminoma	12.5	BRCA1, BRCA2

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], linolenic acid, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

MalaCards organs/tissues related to fallopian tube cancer:

²²

FMA organs/tissues related to fallopian tube cancer:

¹¹

MGI Mouse Phenotypes related to fallopian tube cancer:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail phenotype	MP:0005371	8.6	BRCA1, BRCA2, ERBB2
2	tumorigenesis	MP:0002006	8.6	ERBB2, BRCA2, BRCA1
3	digestive/alimentary phenotype	MP:0005381	8.5	BRCA1, BRCA2, ERBB2
4	endocrine/exocrine gland phenotype	MP:0005379	8.5	BRCA1, BRCA2, ERBB2
5	skeleton phenotype	MP:0005390	8.4	ERBB2, BRCA2, BRCA1
6	integument phenotype	MP:0010771	8.2	BRCA1, BRCA2, ERBB2

Articles related to fallopian tube cancer:

id	Title	Authors	Year	Affiliating Genes
1	Clinical activity of gemcitabine plus pertuzumab in p latinum-resistant ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. (19901115)	Makhija S.... Matulonis U.	2010	ERBB2
2	Occult fallopian tube cancer in a patient with BRCA1 breast cancer. (18971141)	Brown J.V.... Goldstein B.H.	2008	BRCA1
3	A novel Q3034R BRCA2 germline mutation identified in a fallopian tube cancer patient. (12618335)	Baudi F.... Venuta S.	2003	BRCA2
4	Fallopian tube cancer in a BRCA1 mutation carrier: rapid development and failure of screening. (11810084)	HAcbert-Blouin M.N.... Foulkes W.D.	2002	BRCA1
5	Molecular evidence for putative tumour suppressor genes on chromosome 13q specific to BRCA1 related ovarian and fallopian tube cancer. (12354934)	Jongsma A.P.... Kenemans P.	2002	BRCA1

Genes related to fallopian tube cancer according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	BRCA1	breast cancer 1, early onset	11.0	Publications
2	BRCA2	breast cancer 2, early onset	11.0	Publications
3	ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	11.0	Publications

Pathways related to fallopian tube cancer according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Fanconis Anaemia Pathway36	9.2	BRCA1, BRCA2
2	DNA damage Role of Brca1 and Brca2 in DNA repair10	9.2	BRCA1, BRCA2
3	DNA damage_Role of Brca1 and Brca2 in DNA repair41	9.1	BRCA1, BRCA2
4	Pancreatic cancer20	9.1	ERBB2, BRCA2
5	BRCA1 Pathway36	9.1	BRCA1, BRCA2
6	Cell Cycle / Checkpoint Control3	9.0	BRCA1, BRCA2
7	DNA Damage3	8.9	BRCA1, BRCA2
8	DNA Repair Mechanisms36	8.7	BRCA1, BRCA2

Compounds related to fallopian tube cancer according to GeneDecks:

(show all 39)

id	Compound	Score	Top Affiliating Genes
1	etoposide32 42 9 9	13.4	ERBB2
2	vinorelbine32 9 9	11.7	BRCA1, ERBB2
3	topotecan32 9 9	11.7	BRCA1, ERBB2
4	oxaliplatin32 34 9 9	12.6	ERBB2, BRCA1
5	carboplatin32 34 9 9	12.6	BRCA1, ERBB2
6	bortezomib32 9 9	11.6	ERBB2, BRCA1
7	gemcitabine32 34 9 9	12.5	ERBB2, BRCA1
8	daidzein32	9.4	BRCA2, BRCA1
9	8-oxoguanine32	9.4	BRCA2, BRCA1
10	phosphatidylinositol32	9.4	BRCA2, ERBB2
11	indole-3-carbinol32	9.4	BRCA1, BRCA2
12	methylmethanesulfonate32	9.4	BRCA1, BRCA2
13	thymidylate32	9.3	BRCA1, ERBB2
14	cyclophosphamide32 34 9 9	12.3	BRCA1, ERBB2
15	bleomycin32 9 9	11.3	BRCA1, BRCA2
16	adpribose32	9.3	BRCA1, BRCA2
17	hydroxyurea32 9 9	11.2	BRCA2, BRCA1
18	mitomycin c32	9.2	BRCA1, BRCA2
19	p00332	9.1	BRCA1, BRCA2
20	4-hydroxytamoxifen32	8.9	BRCA1, BRCA2, ERBB2
21	gold32	8.9	BRCA2, BRCA1
22	docetaxel32 34 9 9	11.9	ERBB2, BRCA2, BRCA1
23	p00232	8.9	BRCA1, BRCA2, ERBB2
24	resveratrol32 9 18 9	11.9	ERBB2, BRCA2, BRCA1
25	adriamycin32	8.9	BRCA1, BRCA2, ERBB2
26	folate32	8.9	ERBB2, BRCA2, BRCA1
27	methotrexate32 34 42 9 9	12.9	BRCA1, BRCA2, ERBB2
28	tamoxifen32 34 9 9	11.9	ERBB2, BRCA2, BRCA1
29	paclitaxel32 34 9 9	11.9	BRCA1, BRCA2, ERBB2
30	paraffin32	8.9	BRCA1, BRCA2, ERBB2
31	genistein32 9 18 9	11.9	ERBB2, BRCA2, BRCA1
32	cisplatin32 34 9 9	11.9	BRCA1, BRCA2, ERBB2
33	cycloheximide32	8.9	ERBB2, BRCA2, BRCA1
34	progesterone32 42 9 18 9	12.8	ERBB2, BRCA2, BRCA1
35	h2o232	8.8	BRCA1, BRCA2, ERBB2
36	testosterone32 9 18 9	11.8	BRCA1, BRCA2, ERBB2
37	steroid32	8.8	ERBB2, BRCA2, BRCA1
38	camptothecin32 42 9 9	11.7	BRCA1, BRCA2
39	estrogen32	8.6	ERBB2, BRCA2, BRCA1

Biological processes related to fallopian tube cancer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:006978	9.0	BRCA1, BRCA2
2	double-strand break repair	GO:006302	9.0	BRCA1, BRCA2
3	mammary gland development	GO:030879	9.0	BRCA2, ERBB2
4	double-strand break repair via homologous recombination	GO:000724	8.7	BRCA1, BRCA2