MCID: FLL026
MIFTS: 52

Fallopian Tube Cancer malady

Cancer diseases, Reproductive diseases, Nephrological diseases categories

Summaries for Fallopian Tube Cancer

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Primary fallopian tube cancer (PFTC), often just tubal cancer, is a malignant neoplasm that originates... more...

MalaCards: Fallopian Tube Cancer, also known as fallopian tube carcinoma, is related to ovarian cancer and breast cancer. An important gene associated with Fallopian Tube Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are Fanconi anemia pathway and BRCA1 Pathway. The compounds adriamycin and 8-oxoguanine have been mentioned in the context of this disorder. Affiliated tissues include fallopian tube, breast and brain, and related mouse phenotypes are limbs/digits/tail and integument.

Disease Ontology:8 A female reproductive organ cancer that is located in fallopian tube.

Aliases & Classifications for Fallopian Tube Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases, Nephrological diseases


Aliases & Descriptions:

fallopian tube cancer 8 42 10 44
fallopian tube carcinoma 8 10 44 60
cancer of the fallopian tube 8 42
malignant neoplasm of uterine tube 8
malignant tumour of fallopian tube 8
malignant tumor of fallopian tube 8
tumor, fallopian tube, malignant 8
tumor of the fallopian tube 8
carcinoma of fallopian tube 8
neoplasm of fallopian tube 8
fallopian tube neoplasms 60
fallopian tube neoplasm 8
renal tubular disorder 60
fallopian tube ca 8


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Disease Ontology8 DOID:1964, DOID:1963
NCIt39 C3032, C3867
MeSH34 D005185
ICD1025 C57.0

Related Diseases for Fallopian Tube Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Fallopian Tube Cancer family:

Fallopian Tube Benign Neoplasm

Diseases related to Fallopian Tube Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian cancer31.2BRCA1, BRCA2, ESR2, ABCC2, ERBB2
2breast cancer30.7ERBB2, ABCC2, ESR2, BRCA2, BRCA1
3endometriosis30.5ESR2
4sarcoma30.5BRCA2
5adenoma30.3ESR2, BRCA1
6papillary carcinoma30.2ERBB2, BRCA2
7pancreatitis30.2BRCA2
8pancreatic cancer30.2ESR2, BRCA2
9adenocarcinoma30.1ERBB2, BRCA1, ESR2, BRCA2, ABCC2
10peritonitis10.8
11familiar fallopian tube carcinoma10.4
12tuberculous salpingitis10.4
13cervix endometriosis10.3
14fallopian tube endometriosis10.3
15ovarian endometriosis10.3
16endometriosis of ovary10.3
17acromegaly10.3
18ovarian cyst10.3
19ovary sarcoma10.3
20ollier disease10.3
21peritoneum cancer10.3
22fallopian tube carcinosarcoma10.2
23fallopian tube adenomatoid tumor10.2
24klippel-trenaunay syndrome10.2
25adenomatoid tumor10.2
26chronic salpingitis10.2
27salpingitis10.2
28pregnancy adenoma10.2
29ovary papillary carcinoma10.2
30ulceration of vulva10.2
31papillary adenoma10.2
32arthropathy10.2
33endometriosis of uterus10.2
34liver sarcoma10.2
35retroperitoneal sarcoma10.2
36tuberculosis10.2
37proteus syndrome10.2
38carney complex10.2
39muir-torre syndrome10.2
40werner syndrome10.2
41pseudomyxoma peritonei10.2
42turcot syndrome10.2
43desmoplastic small round cell tumor10.2
44hypertrichosis lanuginosa, acquired10.2
45polymyositis10.2
46schopf-schulz-passarge syndrome10.2
4746xy sex reversal 310.2
48proteus syndrome, somatic10.2
49mosaic variegated aneuploidy syndrome 110.2
50primary peritoneal carcinoma10.2

Graphical network of the top 20 diseases related to Fallopian Tube Cancer:



Diseases related to fallopian tube cancer

Clinical Features for Fallopian Tube Cancer

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Drugs & Therapeutics for Fallopian Tube Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Fallopian Tube Cancer

Drug clinical trials:

Search ClinicalTrials for Fallopian Tube Cancer

Search NIH Clinical Center for Fallopian Tube Cancer

Search CenterWatch for Fallopian Tube Cancer

Genetic Tests for Fallopian Tube Cancer

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Anatomical Context for Fallopian Tube Cancer

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Fallopian Tube Cancer:

32
Breast, Brain, Ovary, Endothelial

FMA organs/tissues related to Fallopian Tube Cancer:

14
Fallopian tube

Animal Models for Fallopian Tube Cancer or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Fallopian Tube Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.2BRCA2
2MP:00107719.4BRCA2, BRCA1
3MP:00053799.0BRCA1, BRCA2, ESR2
4MP:00053898.9ERBB2, BRCA2, BRCA1
5MP:00020068.5ESR2, ERBB2, BRCA2, BRCA1
6MP:00053818.5BRCA1, BRCA2, ERBB2, ESR2
7MP:00053908.4ESR2, ERBB2, BRCA2, BRCA1
8MP:00028738.1BRCA1, BRCA2, ERBB2, ESR2
9MP:00053767.6ESR2, ERBB2, ABCC2, BRCA2, BRCA1

Publications for Fallopian Tube Cancer

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Sources:
50PubMed
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Articles related to Fallopian Tube Cancer:

(show top 50)    (show all 89)
idTitleAuthorsYear
1
Revisiting the pathogenesis of ovarian cancer: the central role of the fallopian tube. (24100801)
2014
2
MRP2 (ABCC2, cMOAT) expression in nuclear envelope of primary fallopian tube cancer cells is a new unfavorable prognostic factor. (23135210)
2013
3
Laparoscopic staging for apparent early stage ovarian or fallopian tube cancer. First case series from a UK cancer centre and systematic literature review. (23721765)
2013
4
Independent radiologic review of the Gynecologic Oncology Group Study 0218, a phase III trial of bevacizumab in the primary treatment of advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer. (23906656)
2013
5
Early detection of ovarian and fallopian tube cancer by examination of cytological samples from the endometrial cavity. (23868002)
2013
6
Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in brca;tp53;pten models. (24332043)
2013
7
OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. (22529265)
2012
8
Outcome of single agent generic gemcitabine in platinum-resistant ovarian cancer, fallopian tube cancer and primary peritoneal adenocarcinoma. (22524817)
2012
9
Multidrug resistance gene (MDR-1) and risk of brain metastasis in epithelial ovarian, fallopian tube, and peritoneal cancer. (20921883)
2011
10
Phase 1-2 study of docetaxel plus aflibercept in patients with recurrent ovarian, primary peritoneal, or fallopian tube cancer. (21992853)
2011
11
Para-aortic lymphadenectomy for primary fallopian tube cancer. (20887989)
2011
12
Primary fallopian tube cancer in term pregnancy: a case report. (21614918)
2011
13
Combined weekly topotecan and biweekly bevacizumab in women with platinum-resistant ovarian, peritoneal, or fallopian tube cancer: results of a phase 2 study. (21815133)
2011
14
Phase I study of pemetrexed and pegylated liposomal doxorubicin in patients with refractory breast, ovarian, primary peritoneal, or fallopian tube cancer. (20352294)
2011
15
Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary MA1llerian Tissues. (20041133)
2009
16
A phase II study of GM-CSF and rIFN-gamma1b plus carboplatin for the treatment of recurrent, platinum-sensitive ovarian, fallopian tube and primary peritoneal cancer. (19264351)
2009
17
Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer. (19826113)
2009
18
Phase II evaluation of nanoparticle albumin-bound paclitaxel in platinum-sensitive patients with recurrent ovarian, peritoneal, or fallopian tube cancer. (19224848)
2009
19
Candidate serous cancer precursors in fallopian tube epithelium of BRCA1/2 mutation carriers. (19543244)
2009
20
Fallopian tube cancer presenting as inflammatory breast carcinoma: report of a case and review of the literature. (19899419)
2009
21
Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Consortia. (18423560)
2008
22
A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations. (18342932)
2008
23
Improved survival for fallopian tube cancer: a comparison of clinical characteristics and outcome for primary fallopian tube and ovarian cancer. (19006196)
2008
24
Reversible posterior leukoencephalopathy syndrome following intravenous paclitaxel and intraperitoneal cisplatin chemotherapy for fallopian tube cancer. (18554701)
2008
25
Primary fallopian tube cancer may mimic endometrial malignancy. (18603511)
2008
26
The incidence of primary fallopian tube cancer in the United States. (17961642)
2007
27
Effect of perioperative venous thromboembolism on survival in ovarian, primary peritoneal, and fallopian tube cancer. (17614125)
2007
28
First report of primary fallopian tube cancer diagnosed by liquid-based cytology in an asymptomatic woman. (17877777)
2007
29
A 10-year review of primary fallopian tube cancer at a community hospital: a high association of synchronous and metachronous cancers. (16445606)
2006
30
The founder mutation BRCA1c.2845insA identified in a fallopian tube cancer patient: a case report. (16515624)
2006
31
Inguinal node metastasis as the initial presentation of primary fallopian tube cancer. (16876236)
2006
32
BRCA2 germline mutations in primary cancer of the fallopian tube. (15254695)
2004
33
Phase 2 trial of interferon-beta as second-line treatment of ovarian cancer, fallopian tube cancer, or primary carcinoma of the peritoneum. (15331919)
2004
34
Primary fallopian tube cancer--a ten year review. Clinicopathological study of 12 cases. (15285322)
2004
35
Preoperative diagnosis of fallopian tube cancer by imaging. (14628888)
2003
36
A novel Q3034R BRCA2 germline mutation identified in a fallopian tube cancer patient. (12618335)
2003
37
Fallopian tube cancer in a BRCA1 mutation carrier: rapid development and failure of screening. (11810084)
2002
38
Occult cancer of the fallopian tube in BRCA-1 germline mutation carriers at prophylactic oophorectomy: a case for recommending hysterectomy at surgical prophylaxis. (11161856)
2001
39
Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer. (11745677)
2001
40
Long-term survival of a patient with fallopian tube cancer presenting with a supraclavicular mass. (11205221)
2000
41
Treatment of fallopian tube cancer. Review of the literature. (10985612)
2000
42
Diagnostic dilemmas and current therapy of Fallopian tube cancer. (10376425)
1999
43
Primary fallopian tube cancer: a review of the literature. (9643524)
1998
44
Fallopian tube cancer: incidence and role of lymphatic spread. (8751549)
1996
45
Modulation of platinum sensitivity and resistance by cyclosporin A in refractory ovarian and fallopian tube cancer patients: a phase II study. (9816118)
1996
46
DNA-ploidy and mutant p53 overexpression in primary fallopian tube cancer. (11578443)
1994
47
Fallopian tube cancer metastatic to the breast. (8005136)
1994
48
Staging rules for gestational trophoblastic tumors and fallopian tube cancer. (1317647)
1992
49
Immunolymphoscintigraphy and immunoscintigraphy of ovarian and fallopian tube cancer using F(ab')2 fragments of monoclonal antibody OC 125. (2297745)
1990
50
Fallopian tube cancer. (3189120)
1988

Genetic Variations for Fallopian Tube Cancer

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Expression for genes affiliated with Fallopian Tube Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fallopian Tube Cancer

Search GEO for disease gene expression data for Fallopian Tube Cancer.

Pathways for genes affiliated with Fallopian Tube Cancer

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Sources:
29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Fallopian Tube Cancer

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1adriamycin4410.1ABCC2
28-oxoguanine449.8BRCA1, BRCA2
3lycopene44 2410.8BRCA2, BRCA1
4h2o2449.7ESR2, ERBB2
5indole-3-carbinol449.7BRCA1, BRCA2
6vinorelbine44 1110.7ERBB2, BRCA1
7methylmethanesulfonate449.7BRCA2, BRCA1
8exemestane49 44 59 1112.7ERBB2, ESR2
9toremifene44 1110.7ESR2, ERBB2
10fulvestrant44 49 28 1112.6ESR2, ERBB2
11letrozole44 49 59 1112.6ESR2, ERBB2
1217beta-hydroxysteroid449.6BRCA1, ESR2
13platinum44 4910.4ABCC2, BRCA1
14daidzein449.4ESR2, BRCA1, BRCA2
15sunitinib44 49 1111.3ABCC2, ERBB2
16raloxifene44 28 49 1112.3ESR2, ERBB2
17taxane449.3ABCC2, ERBB2
18thymidylate449.3ESR2, ERBB2, BRCA1
19p002449.3BRCA2, ERBB2, BRCA1
20steroid449.2BRCA1, BRCA2, ERBB2
21estradiol44 11 2411.2BRCA1, ESR2, BRCA2
22leucovorin44 49 1111.2ERBB2, ABCC2
23mitoxantrone44 49 1111.1ABCC2, ERBB2
24bortezomib44 1110.1ERBB2, BRCA1
25mitomycin c449.1BRCA1, BRCA2, ABCC2
26vincristine44 49 1111.1BRCA1, ABCC2, BRCA2
27camptothecin44 59 1111.0ABCC2, BRCA2, BRCA1
28irinotecan44 49 1111.0ABCC2, ERBB2
29topotecan44 1110.0BRCA1, ERBB2, ABCC2
30oxaliplatin44 49 1111.0BRCA1, ERBB2, ABCC2
31carboplatin44 49 1111.0ERBB2, ABCC2, BRCA1
32carbamazepine44 49 1110.9ABCC2, ERBB2
335fluorouracil448.9ERBB2, ABCC2, BRCA1
344-hydroxytamoxifen448.8BRCA1, BRCA2, ERBB2, ESR2
35resveratrol44 59 11 2411.8BRCA1, BRCA2, ERBB2, ESR2
36paraffin448.8BRCA1, BRCA2, ERBB2, ESR2
37testosterone44 59 11 2411.7BRCA1, BRCA2, ERBB2, ESR2
38retinoic acid44 249.5ESR2, BRCA1, BRCA2, ABCC2
39docetaxel44 49 59 1111.5BRCA2, ABCC2, BRCA1, ERBB2
40folate448.5BRCA1, BRCA2, ABCC2, ERBB2
41methotrexate44 49 1110.5BRCA2, BRCA1, ERBB2, ABCC2
42paclitaxel44 49 1110.5ERBB2, ABCC2, BRCA1, BRCA2
43doxorubicin44 49 1110.5BRCA1, ABCC2, ESR2, ERBB2
44cisplatin44 49 59 1111.4BRCA1, ERBB2, ABCC2, BRCA2
45etoposide44 49 59 1111.0ESR2, ERBB2, ABCC2, BRCA2, BRCA1
46tamoxifen44 49 28 1111.0ESR2, BRCA2, ABCC2, ERBB2, BRCA1
47genistein44 28 59 2 11 2413.0ABCC2, ERBB2, BRCA1, ESR2, BRCA2
48cycloheximide448.0BRCA2, ESR2, ERBB2, ABCC2, BRCA1
49progesterone44 59 28 11 2412.0ERBB2, BRCA2, BRCA1, ESR2, ABCC2
50estrogen448.0ESR2, ERBB2, BRCA2, ABCC2, BRCA1

GO Terms for genes affiliated with Fallopian Tube Cancer

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16Gene Ontology
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Biological processes related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-strand break repairGO:0063029.5BRCA2, BRCA1
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.4BRCA2, BRCA1
3double-strand break repair via homologous recombinationGO:0007249.2BRCA2, BRCA1

Products for genes affiliated with Fallopian Tube Cancer

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Sources for Fallopian Tube Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet