MCID: FLL026
MIFTS: 45

Fallopian Tube Cancer malady

Cancer category

Summaries for Fallopian Tube Cancer

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Primary fallopian tube cancer (PFTC), often just tubal cancer, is a malignant neoplasm that originates... more...

MalaCards: Fallopian Tube Cancer, also known as fallopian tube carcinoma, is related to peritoneal carcinoma and adenoma. An important gene associated with Fallopian Tube Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are Fanconi anemia pathway and BRCA1 Pathway. The compounds adriamycin and 8-oxoguanine have been mentioned in the context of this disorder. Affiliated tissues include fallopian tube, and related mouse phenotypes are limbs/digits/tail and integument.

Disease Ontology:8 A female reproductive organ cancer that is located in fallopian tube.

Aliases & Classifications for Fallopian Tube Cancer

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

fallopian tube cancer 8 43 10 45
fallopian tube carcinoma 8 10 45 61
cancer of the fallopian tube 8 43
malignant neoplasm of uterine tube 8
malignant tumour of fallopian tube 8
malignant tumor of fallopian tube 8
tumor, fallopian tube, malignant 8
tumor of the fallopian tube 8
carcinoma of fallopian tube 8
neoplasm of fallopian tube 8
fallopian tube neoplasms 61
fallopian tube neoplasm 8
renal tubular disorder 61
fallopian tube ca 8


External Ids:

Disease Ontology8 DOID:1964, DOID:1963
NCIt40 C3032, C3867
MeSH35 D005185
ICD1025 C57.0

Related Diseases for Fallopian Tube Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Fallopian Tube Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1peritoneal carcinoma30.5BRCA1, BRCA2
2adenoma30.4ESR2, BRCA1
3papillary carcinoma30.3ERBB2, BRCA2
4adenocarcinoma30.2ESR2, ERBB2, ABCC2, BRCA2, BRCA1
5ovarian epithelial cancer10.6
6familiar fallopian tube carcinoma10.4
7tuberculous salpingitis10.4
8cervix endometriosis10.4
9fallopian tube endometriosis10.4
10ovarian endometriosis10.4
11acromegaly10.4
12ollier disease10.3
13fallopian tube adenomatoid tumor10.3
14klippel-trenaunay syndrome10.3
15adenomatoid tumor10.3
16malignant mixed mullerian tumor10.3
17malignant germ cell tumor10.3
18mixed germ cell tumor10.3
19pregnancy adenoma10.2
20ovary papillary carcinoma10.2
21papillary adenoma10.2
22arthropathy10.2
23tuberculosis10.2
24hydatidiform mole, recurrent10.2
25proteus syndrome10.2
26carney complex10.2
27muir-torre syndrome10.2
28werner syndrome10.2
29pseudomyxoma peritonei10.2
30n syndrome10.2
31turcot syndrome10.2
32desmoplastic small round cell tumor10.2
33hypertrichosis lanuginosa, acquired10.2
34polymyositis10.2
35schopf-schulz-passarge syndrome10.2
3646xy sex reversal 310.2
37proteus syndrome, somatic10.2
38mosaic variegated aneuploidy syndrome 110.2
39primary peritoneal carcinoma10.2
40segmental outgrowth - lipomatosis - arteriovenous malformation - epidermal nevus10.2
41estrogen-receptor positive breast cancer10.2
42cardia cancer10.2
43inflammatory breast carcinoma10.2
44gestational trophoblastic tumor10.2
45thromboembolism10.2
46venous thromboembolism10.2
47malignant tumor of fallopian tubes10.2
48borderline ovarian epithelial tumor10.2
49endocervical carcinoma10.2
50ectopic pregnancy10.2

Graphical network of the top 20 diseases related to Fallopian Tube Cancer:



Diseases related to fallopian tube cancer

Clinical Features for Fallopian Tube Cancer

Drugs & Therapeutics for Fallopian Tube Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Fallopian Tube Cancer

Drug clinical trials:

Search ClinicalTrials for Fallopian Tube Cancer

Search NIH Clinical Center for Fallopian Tube Cancer

Search CenterWatch for Fallopian Tube Cancer

Genetic Tests for Fallopian Tube Cancer

Anatomical Context for Fallopian Tube Cancer

Sources:
14FMA
See all sources

FMA organs/tissues related to Fallopian Tube Cancer:

14
Fallopian tube

Animal Models for Fallopian Tube Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Fallopian Tube Cancer

Sources:
51PubMed
See all sources

Articles related to Fallopian Tube Cancer:

(show top 50)    (show all 89)
idTitleAuthorsYear
1
MRP2 (ABCC2, cMOAT) expression in nuclear envelope of primary fallopian tube cancer cells is a new unfavorable prognostic factor. (23135210)
2013
2
Increased incidence of severe gastrointestinal events with first-line paclitaxel, carboplatin, and vorinostat chemotherapy for advanced-stage epithelial ovarian, primary peritoneal, and fallopian tube cancer. (23385285)
2013
3
Outcome of single agent generic gemcitabine in platinum-resistant ovarian cancer, fallopian tube cancer and primary peritoneal adenocarcinoma. (22524817)
2012
4
Junctional epithelial zones of the fallopian tube: cancer hotspots? (21131841)
2011
5
Asymptomatic primary fallopian tube cancer: an unusual cause of axillary lymphadenopathy. (22567506)
2011
6
Phase II trial of intraperitoneal cisplatin combined with intravenous paclitaxel in patients with ovarian, primary peritoneal and fallopian tube cancer. (21664657)
2011
7
Unexpected gastrointestinal toxicity from Docetaxel/Carboplatin/Erlotinib followed by maintenance Erlotinib treatment for newly diagnosed stage III/IV ovarian cancer, primary peritoneal, or fallopian tube cancer. (21324515)
2011
8
Clinical activity of gemcitabine plus pertuzumab in platinum-resistant ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. (19901115)
2010
9
Immunohistochemical findings in primary fallopian tube cancer. Case report. (20349798)
2010
10
Cancer-associated retinopathy in neuroendocrine carcinoma of the fallopian tube. (20724944)
2010
11
A phase II study of GM-CSF and rIFN-gamma1b plus carboplatin for the treatment of recurrent, platinum-sensitive ovarian, fallopian tube and primary peritoneal cancer. (19264351)
2009
12
Phase II evaluation of nanoparticle albumin-bound paclitaxel in platinum-sensitive patients with recurrent ovarian, peritoneal, or fallopian tube cancer. (19224848)
2009
13
High rates of occult fallopian tube cancer diagnosed at prophylactic bilateral salpingo-oophorectomy. (19574767)
2009
14
Incidence and management of pancreatic leaks after splenectomy with distal pancreatectomy performed during primary cytoreductive surgery for advanced ovarian, peritoneal and fallopian tube cancer. (19091388)
2009
15
Case report: Occurrence of fallopian tube cancer in a patient with previous history of estrogen receptor positive breast cancer. (20103847)
2009
16
Systematic lymphadenectomy improves survival in patients with advanced-stage primary fallopian tube cancer. (19398867)
2009
17
Liquid-based cytology aids in primary fallopian tube cancer diagnosis. (19650204)
2009
18
Validation of epithelial ovarian cancer and fallopian tube cancer and ovarian borderline tumor data in the Danish Gynecological Cancer Database. (19308749)
2009
19
A phase II study of cetuximab/paclitaxel/carboplatin for the initial treatment of advanced-stage ovarian, primary peritoneal, or fallopian tube cancer. (18554700)
2008
20
A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations. (18342932)
2008
21
Fallopian tube cancer associated with paraneoplastic dermatomyositis -- asymptomatic multivisceral exacerbated dermatomyositis mimicking recurrent widespread malignant disease: case report. (18459555)
2008
22
Synchronous occult cancers of the endometrium and fallopian tube in an MSH2 mutation carrier at time of prophylactic surgery. (18805575)
2008
23
Paclitaxel poliglumex and carboplatin as first-line therapy in ovarian, peritoneal or fallopian tube cancer: a phase I and feasibility trial of the Gynecologic Oncology Group. (18597837)
2008
24
Fallopian tube cancer: radical surgery, extended field radiation and chemotherapy in 24 personal cases treated with "intent to cure". (18973932)
2008
25
Improved survival for fallopian tube cancer: a comparison of clinical characteristics and outcome for primary fallopian tube and ovarian cancer. (19006196)
2008
26
Treatment of recurrent or persistent platinum-refractory ovarian, fallopian tube or primary peritoneal cancer with gemcitabine and topotecan: a phase II trial of the Puget Sound Oncology Consortium. (18538834)
2008
27
Occult fallopian tube cancer in a patient with BRCA1 breast cancer. (18971141)
2008
28
Primary fallopian tube cancer may mimic endometrial malignancy. (18603511)
2008
29
Second primary malignancies in females with primary fallopian tube cancer. (17266029)
2007
30
A phase II study of outpatient first-line paclitaxel, carboplatin, and bevacizumab for advanced-stage epithelial ovarian, peritoneal, and fallopian tube cancer. (17343605)
2007
31
Fallopian tube cancer: stepchild or mother? (18053873)
2007
32
Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction. (17761984)
2007
33
Phenotypic variability of a 4q34-->qter inherited deletion: MRKH syndrome in the daughter, cardiac defect and Fallopian tube cancer in the mother. (17081814)
2007
34
A 10-year review of primary fallopian tube cancer at a community hospital: a high association of synchronous and metachronous cancers. (16445606)
2006
35
Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 Mutation. (16835424)
2006
36
Inguinal node metastasis as the initial presentation of primary fallopian tube cancer. (16876236)
2006
37
The significance of Doppler flow and anamnesis in the diagnosis of fallopian tube cancer. (15991534)
2005
38
A phase II trial of weekly docetaxel in patients with platinum-resistant epithelial ovarian, primary peritoneal serous cancer, or fallopian tube cancer. (15581974)
2004
39
Occult cancer of the fallopian tube in a BRCA2 germline mutation carrier at prophylactic salpingo-oophorectomy. (14984974)
2004
40
Phase 2 trial of interferon-beta as second-line treatment of ovarian cancer, fallopian tube cancer, or primary carcinoma of the peritoneum. (15331919)
2004
41
Phase 2 trial of single agent docetaxel in platinum and paclitaxel-refractory ovarian cancer, fallopian tube cancer, and primary carcinoma of the peritoneum. (14675679)
2003
42
Molecular evidence for putative tumour suppressor genes on chromosome 13q specific to BRCA1 related ovarian and fallopian tube cancer. (12354934)
2002
43
Long-term survival of a patient with fallopian tube cancer presenting with a supraclavicular mass. (11205221)
2000
44
Fallopian tube cancer as a feature of BRCA1-associated syndromes. (10926816)
2000
45
Molecular evidence linking primary cancer of the fallopian tube to BRCA1 germline mutations. (10620440)
2000
46
Prognostic significance of tumor angiogenesis in primary fallopian tube cancer. (10454260)
1999
47
Fallopian tube cancer: incidence and role of lymphatic spread. (8751549)
1996
48
Modulation of platinum sensitivity and resistance by cyclosporin A in refractory ovarian and fallopian tube cancer patients: a phase II study. (9816118)
1996
49
Fallopian tube cancer. The Roswell Park experience. (2249208)
1990
50
Fallopian tube cancer: the role of radiation therapy. (3444903)
1987

Genetic Variations for Fallopian Tube Cancer

Expression for genes affiliated with Fallopian Tube Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Fallopian Tube Cancer

Search GEO for disease gene expression data for Fallopian Tube Cancer.

Pathways for genes affiliated with Fallopian Tube Cancer

Sources:
30KEGG, 52QIAGEN, 54Reactome, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Fallopian Tube Cancer

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1adriamycin4510.1ABCC2
28-oxoguanine459.8BRCA1, BRCA2
3lycopene45 2410.8BRCA1, BRCA2
4h2o2459.7ESR2, ERBB2
5indole-3-carbinol459.7BRCA2, BRCA1
6vinorelbine45 1110.7ERBB2, BRCA1
7exemestane50 45 60 1112.7ESR2, ERBB2
8toremifene45 1110.7ERBB2, ESR2
9methylmethanesulfonate459.6BRCA1, BRCA2
10fulvestrant45 50 29 1112.6ESR2, ERBB2
11letrozole45 50 60 1112.6ERBB2, ESR2
1217beta-hydroxysteroid459.6BRCA1, ESR2
13platinum45 5010.4ABCC2, BRCA1
14daidzein459.4BRCA1, BRCA2, ESR2
15sunitinib45 50 1111.3ABCC2, ERBB2
16raloxifene45 29 50 1112.3ESR2, ERBB2
17taxane459.3ABCC2, ERBB2
18thymidylate459.3BRCA1, ERBB2, ESR2
19p002459.3ERBB2, BRCA2, BRCA1
20steroid459.2ERBB2, BRCA2, BRCA1
21leucovorin45 50 1111.2ABCC2, ERBB2
22estradiol45 11 2411.2BRCA1, BRCA2, ESR2
23mitoxantrone45 50 1111.1ERBB2, ABCC2
24bortezomib45 1110.1ERBB2, BRCA1
25mitomycin c459.1ABCC2, BRCA2, BRCA1
26vincristine45 50 1111.1ABCC2, BRCA2, BRCA1
27camptothecin45 60 1111.0BRCA1, BRCA2, ABCC2
28irinotecan45 50 1111.0ERBB2, ABCC2
29topotecan45 1110.0ERBB2, ABCC2, BRCA1
30oxaliplatin45 50 1111.0ERBB2, ABCC2, BRCA1
31carboplatin45 50 1111.0ERBB2, ABCC2, BRCA1
32carbamazepine45 50 1110.9ERBB2, ABCC2
335fluorouracil458.9BRCA1, ABCC2, ERBB2
344-hydroxytamoxifen458.8BRCA1, BRCA2, ERBB2, ESR2
35resveratrol45 60 11 2411.8BRCA1, BRCA2, ERBB2, ESR2
36paraffin458.8BRCA1, BRCA2, ERBB2, ESR2
37testosterone45 60 11 2411.7ESR2, ERBB2, BRCA2, BRCA1
38retinoic acid45 249.5ESR2, ABCC2, BRCA2, BRCA1
39docetaxel45 50 60 1111.5BRCA1, BRCA2, ABCC2, ERBB2
40folate458.5ERBB2, ABCC2, BRCA2, BRCA1
41methotrexate45 50 1110.5BRCA1, BRCA2, ABCC2, ERBB2
42paclitaxel45 50 1110.5BRCA1, BRCA2, ABCC2, ERBB2
43doxorubicin45 50 1110.5BRCA1, ABCC2, ERBB2, ESR2
44cisplatin45 50 60 1111.4BRCA1, BRCA2, ABCC2, ERBB2
45etoposide45 50 60 1111.0ESR2, ERBB2, ABCC2, BRCA2, BRCA1
46tamoxifen45 50 29 1111.0BRCA1, BRCA2, ABCC2, ERBB2, ESR2
47genistein45 29 60 2 11 2413.0ESR2, ERBB2, ABCC2, BRCA2, BRCA1
48cycloheximide458.0BRCA1, BRCA2, ABCC2, ERBB2, ESR2
49progesterone45 60 29 11 2412.0ESR2, ERBB2, ABCC2, BRCA2, BRCA1
50estrogen458.0BRCA1, BRCA2, ABCC2, ERBB2, ESR2

GO Terms for genes affiliated with Fallopian Tube Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-strand break repairGO:0063029.5BRCA2, BRCA1
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.4BRCA2, BRCA1
3double-strand break repair via homologous recombinationGO:0007249.2BRCA2, BRCA1

Products for genes affiliated with Fallopian Tube Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fallopian Tube Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet