MCID: FLL026
MIFTS: 48

Fallopian Tube Cancer malady

Rare diseases, Cancer diseases, Reproductive diseases categories

Summaries for Fallopian Tube Cancer

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Wikipedia:63 Primary fallopian tube cancer (PFTC), often just tubal cancer, is a malignant neoplasm that originates... more...

MalaCards based summary: Fallopian Tube Cancer, also known as fallopian tube carcinoma, is related to peritoneal carcinoma and breast cancer. An important gene associated with Fallopian Tube Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are Fanconi anemia pathway and DNA Repair. The compounds 8-oxoguanine and lycopene have been mentioned in the context of this disorder. Affiliated tissues include fallopian tube, breast and lymph node, and related mouse phenotypes are renal/urinary system and limbs/digits/tail.

Disease Ontology:9 A female reproductive organ cancer that is located in fallopian tube.

Aliases & Classifications for Fallopian Tube Cancer

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 60UMLS, 47Orphanet, 55SNOMED-CT, 38NCIt, 33MeSH, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Fallopian Tube Cancer, Aliases & Descriptions:

Name: Fallopian Tube Cancer 9 41 11 43
Fallopian Tube Carcinoma 9 11 43 60
Cancer of the Fallopian Tube 9 41
Malignant Neoplasm of Fallopian Tube 60
Malignant Neoplasm of Uterine Tube 9
Malignant Tumour of Fallopian Tube 9
Malignant Tumor of Fallopian Tubes 47
Malignant Tumor of Fallopian Tube 9
Tumor, Fallopian Tube, Malignant 9
 
Tumor of the Fallopian Tube 9
Carcinoma of Fallopian Tube 9
Neoplasm of Fallopian Tube 9
Cancer of Fallopian Tubes 47
Fallopian Tube Neoplasms 60
Fallopian Tube Neoplasm 9
Malignant Tubal Tumor 47
Fallopian Tube Ca 9
Tubal Cancer 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

47
malignant tumor of fallopian tubes:
Prevalence: 1-9/100000 (Europe)


External Ids:

Disease Ontology9 DOID:1964, DOID:1963
NCIt38 C3032, C3867
MeSH33 D005185
Orphanet47 180242
ICD10 via Orphanet26 C57.0
UMLS via Orphanet61 C0153579
ICD1025 C57.0

Related Diseases for Fallopian Tube Cancer

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Diseases related to Fallopian Tube Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1peritoneal carcinoma30.9BRCA2, BRCA1
2breast cancer30.8ERBB2, BRCA1
3cowden disease30.6BRCA2, BRCA1
4adenocarcinoma29.3ERBB2, ESR2, BRCA1, BRCA2, ABCC2
5peritonitis10.9
6familiar fallopian tube carcinoma10.4
7tuberculous salpingitis10.4
8hereditary breast ovarian cancer10.4BRCA2
9acromegaly10.4
10endometriosis10.4
11sarcoma10.4
12adenomatoid tumor10.3
13chronic salpingitis10.3
14salpingitis10.3
15malignant mixed mullerian tumor10.3
16ulceration of vulva10.3
17adenoma10.3
18arthropathy10.3
19tuberculosis10.3
20basal cell nevus syndrome10.2
21muir-torre syndrome10.2
22schopf-schulz-passarge syndrome10.2
23werner syndrome10.2
24peutz-jeghers syndrome10.2
25proteus syndrome, somatic10.2
26ollier disease10.2
27pseudomyxoma peritonei10.2
28maffucci syndrome10.2
29desmoplastic small round cell tumor10.2
30hypertrichosis lanuginosa, acquired10.2
31mosaic variegated aneuploidy syndrome10.2
32polymyositis10.2
33primary peritoneal carcinoma10.2
34segmental outgrowth - lipomatosis - arteriovenous malformation - epidermal nevus10.2
3546,xy partial gonadal dysgenesis10.2
36non-polyposis turcot syndrome10.2
37brca1 and brca2 hereditary breast and ovarian cancer10.2BRCA2, BRCA1
38uterine carcinosarcoma10.2
39endocervicitis10.2
40dermatitis10.2
41fallopian tube adenocarcinoma10.2
42pelvic inflammatory disease10.2
43ectopic pregnancy10.2
44exfoliative dermatitis10.2
45estrogen-receptor positive breast cancer10.2
46inflammatory breast carcinoma10.2
47dermatomyositis10.2
48fallopian tube carcinosarcoma10.2
49pancreatitis10.2
50cerebellar degeneration10.2

Graphical network of the top 20 diseases related to Fallopian Tube Cancer:



Diseases related to fallopian tube cancer

Symptoms for Fallopian Tube Cancer

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Drugs & Therapeutics for Fallopian Tube Cancer

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Drug clinical trials:

Search ClinicalTrials for Fallopian Tube Cancer

Search NIH Clinical Center for Fallopian Tube Cancer

Genetic Tests for Fallopian Tube Cancer

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Anatomical Context for Fallopian Tube Cancer

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MalaCards organs/tissues related to Fallopian Tube Cancer:

31
Breast, Lymph node

FMA organs/tissues related to Fallopian Tube Cancer:

14
Fallopian tube

Animal Models for Fallopian Tube Cancer or affiliated genes

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Publications for Fallopian Tube Cancer

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Articles related to Fallopian Tube Cancer:

(show top 50)    (show all 83)
idTitleAuthorsYear
1
A phase 2 study of cediranib in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: A trial of the Princess Margaret, Chicago and California Phase II Consortia. (25895616)
2015
2
Surgical diagnosis of stage I fallopian tube cancer in anti-Yo antibody paraneoplastic cerebellar degeneration. (24960213)
2014
3
A multicenter, non-randomized, phase II study of docetaxel and carboplatin administered every 3 weeks as second line chemotherapy in patients with first relapse of platinum sensitive epithelial ovarian, peritoneal or fallopian tube cancer. (25494701)
2014
4
Clinical characteristics and outcomes of patients with stage I epithelial ovarian cancer compared with fallopian tube cancer. (25514761)
2014
5
Paraneoplastic Neurological Syndrome in Fallopian Tube Cancer. (25364036)
2014
6
MRP2 (ABCC2, cMOAT) expression in nuclear envelope of primary fallopian tube cancer cells is a new unfavorable prognostic factor. (23135210)
2013
7
Laparoscopic staging for apparent early stage ovarian or fallopian tube cancer. First case series from a UK cancer centre and systematic literature review. (23721765)
2013
8
Independent radiologic review of the Gynecologic Oncology Group Study 0218, a phase III trial of bevacizumab in the primary treatment of advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer. (23906656)
2013
9
Early detection of ovarian and fallopian tube cancer by examination of cytological samples from the endometrial cavity. (23868002)
2013
10
Increased incidence of severe gastrointestinal events with first-line paclitaxel, carboplatin, and vorinostat chemotherapy for advanced-stage epithelial ovarian, primary peritoneal, and fallopian tube cancer. (23385285)
2013
11
OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. (22529265)
2012
12
Outcome of single agent generic gemcitabine in platinum-resistant ovarian cancer, fallopian tube cancer and primary peritoneal adenocarcinoma. (22524817)
2012
13
Phase 1-2 study of docetaxel plus aflibercept in patients with recurrent ovarian, primary peritoneal, or fallopian tube cancer. (21992853)
2011
14
Para-aortic lymphadenectomy for primary fallopian tube cancer. (20887989)
2011
15
Junctional epithelial zones of the fallopian tube: cancer hotspots? (21131841)
2011
16
Asymptomatic primary fallopian tube cancer: an unusual cause of axillary lymphadenopathy. (22567506)
2011
17
Primary fallopian tube cancer in term pregnancy: a case report. (21614918)
2011
18
Combined weekly topotecan and biweekly bevacizumab in women with platinum-resistant ovarian, peritoneal, or fallopian tube cancer: results of a phase 2 study. (21815133)
2011
19
Clinical activity of gemcitabine plus pertuzumab in platinum-resistant ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. (19901115)
2010
20
Immunohistochemical findings in primary fallopian tube cancer. Case report. (20349798)
2010
21
Phase II evaluation of nanoparticle albumin-bound paclitaxel in platinum-sensitive patients with recurrent ovarian, peritoneal, or fallopian tube cancer. (19224848)
2009
22
High rates of occult fallopian tube cancer diagnosed at prophylactic bilateral salpingo-oophorectomy. (19574767)
2009
23
Incidence and management of pancreatic leaks after splenectomy with distal pancreatectomy performed during primary cytoreductive surgery for advanced ovarian, peritoneal and fallopian tube cancer. (19091388)
2009
24
Case report: Occurrence of fallopian tube cancer in a patient with previous history of estrogen receptor positive breast cancer. (20103847)
2009
25
A phase II study of cetuximab/paclitaxel/carboplatin for the initial treatment of advanced-stage ovarian, primary peritoneal, or fallopian tube cancer. (18554700)
2008
26
Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Consortia. (18423560)
2008
27
Fallopian tube cancer associated with paraneoplastic dermatomyositis -- asymptomatic multivisceral exacerbated dermatomyositis mimicking recurrent widespread malignant disease: case report. (18459555)
2008
28
Paclitaxel poliglumex and carboplatin as first-line therapy in ovarian, peritoneal or fallopian tube cancer: a phase I and feasibility trial of the Gynecologic Oncology Group. (18597837)
2008
29
Fallopian tube cancer: radical surgery, extended field radiation and chemotherapy in 24 personal cases treated with "intent to cure". (18973932)
2008
30
Second primary malignancies in females with primary fallopian tube cancer. (17266029)
2007
31
A phase II study of outpatient first-line paclitaxel, carboplatin, and bevacizumab for advanced-stage epithelial ovarian, peritoneal, and fallopian tube cancer. (17343605)
2007
32
Fallopian tube cancer: stepchild or mother? (18053873)
2007
33
The incidence of primary fallopian tube cancer in the United States. (17961642)
2007
34
A 10-year review of primary fallopian tube cancer at a community hospital: a high association of synchronous and metachronous cancers. (16445606)
2006
35
The founder mutation BRCA1c.2845insA identified in a fallopian tube cancer patient: a case report. (16515624)
2006
36
The significance of Doppler flow and anamnesis in the diagnosis of fallopian tube cancer. (15991534)
2005
37
A phase II trial of weekly docetaxel in patients with platinum-resistant epithelial ovarian, primary peritoneal serous cancer, or fallopian tube cancer. (15581974)
2004
38
Phase 2 trial of interferon-beta as second-line treatment of ovarian cancer, fallopian tube cancer, or primary carcinoma of the peritoneum. (15331919)
2004
39
Phase 2 trial of single agent docetaxel in platinum and paclitaxel-refractory ovarian cancer, fallopian tube cancer, and primary carcinoma of the peritoneum. (14675679)
2003
40
Preoperative diagnosis of fallopian tube cancer by imaging. (14628888)
2003
41
Molecular evidence for putative tumour suppressor genes on chromosome 13q specific to BRCA1 related ovarian and fallopian tube cancer. (12354934)
2002
42
Long-term survival of a patient with fallopian tube cancer presenting with a supraclavicular mass. (11205221)
2000
43
Fallopian tube cancer as a feature of BRCA1-associated syndromes. (10926816)
2000
44
Practice guidelines: fallopian tube cancer. Society of Gynecologic Oncologists Clinical Practice Guidelines. (9507528)
1998
45
Fallopian tube cancer: incidence and role of lymphatic spread. (8751549)
1996
46
DNA-ploidy and mutant p53 overexpression in primary fallopian tube cancer. (11578443)
1994
47
Fallopian tube cancer metastatic to the breast. (8005136)
1994
48
Staging rules for gestational trophoblastic tumors and fallopian tube cancer. (1317647)
1992
49
Fallopian tube cancer. The Roswell Park experience. (2249208)
1990
50
Immunolymphoscintigraphy and immunoscintigraphy of ovarian and fallopian tube cancer using F(ab')2 fragments of monoclonal antibody OC 125. (2297745)
1990

Variations for Fallopian Tube Cancer

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Expression for genes affiliated with Fallopian Tube Cancer

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Search GEO for disease gene expression data for Fallopian Tube Cancer.

Pathways for genes affiliated with Fallopian Tube Cancer

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Pathways related to Fallopian Tube Cancer according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5BRCA2, BRCA1
2
Show member pathways
9.5BRCA1, BRCA2
39.5BRCA2, BRCA1
49.5BRCA1, BRCA2
5
Show member pathways
9.5BRCA1, BRCA2
6
Show member pathways
9.5BRCA1, BRCA2
7
Show member pathways
9.5BRCA2, BRCA1
89.5ERBB2, BRCA1
9
Show member pathways
9.4BRCA2, ERBB2
10
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.1ERBB2, ESR2
11
Show member pathways
Development Ligand independent activation of ESR1 and ESR258
9.1ESR2, ERBB2
12
Show member pathways
Signaling Pathways in Glioblastoma36
9.0ERBB2, BRCA1, BRCA2
13
Show member pathways
8.7BRCA2, BRCA1, ESR2
14
Show member pathways
8.7ERBB2, ESR2, BRCA1
158.2ERBB2, ESR2, BRCA1, BRCA2
16
Show member pathways
8.2ERBB2, ESR2, BRCA1, BRCA2

Compounds for genes affiliated with Fallopian Tube Cancer

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Compounds related to Fallopian Tube Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
18-oxoguanine439.8BRCA1, BRCA2
2lycopene43 2410.8BRCA2, BRCA1
3vinorelbine43 49 1211.8BRCA1, ERBB2
4indole-3-carbinol439.6BRCA1, BRCA2
5sunitinib43 49 1211.6ABCC2, ERBB2
6methylmethanesulfonate439.6BRCA1, BRCA2
7platinum43 4910.6BRCA1, ABCC2
8taxane439.6ABCC2, ERBB2
9anastrozole43 49 1211.5ESR2, ERBB2
10exemestane43 49 59 1212.5ESR2, ERBB2
11toremifene43 1210.4ERBB2, ESR2
12fulvestrant43 49 28 1212.4ESR2, ERBB2
13mitoxantrone43 49 1211.4ABCC2, ERBB2
14letrozole43 49 59 1212.4ESR2, ERBB2
15p002439.3BRCA2, BRCA1, ERBB2
16carbamazepine43 49 1211.3ERBB2, ABCC2
17topotecan43 1210.3ERBB2, BRCA1, ABCC2
18oxaliplatin43 49 1211.3ERBB2, BRCA1, ABCC2
19carboplatin43 49 1211.3ABCC2, BRCA1, ERBB2
20mitomycin c439.3BRCA1, BRCA2, ABCC2
21vincristine43 49 1211.3BRCA1, BRCA2, ABCC2
22camptothecin43 59 1211.2BRCA1, BRCA2, ABCC2
23leucovorin43 49 1211.2ERBB2, ABCC2
245fluorouracil439.2ERBB2, BRCA1, ABCC2
2517beta-hydroxysteroid439.2ESR2, BRCA1
26daidzein439.1ESR2, BRCA1, BRCA2
27thymidylate439.1BRCA1, ESR2, ERBB2
28estradiol43 24 1210.9BRCA2, BRCA1, ESR2
29egcg438.9ABCC2, ESR2, ERBB2
30raloxifene43 49 28 1211.8ERBB2, ESR2
31adriamycin438.8ABCC2, BRCA2, BRCA1, ERBB2
32docetaxel43 49 59 1211.8ABCC2, BRCA2, BRCA1, ERBB2
33folate438.8ABCC2, BRCA2, BRCA1, ERBB2
34methotrexate49 43 1210.8ABCC2, BRCA2, BRCA1, ERBB2
35paclitaxel43 49 1210.8ABCC2, BRCA2, BRCA1, ERBB2
36cisplatin43 49 59 1211.8ABCC2, BRCA2, BRCA1, ERBB2
374-hydroxytamoxifen438.6BRCA2, BRCA1, ESR2, ERBB2
38resveratrol43 59 24 1211.6ERBB2, ESR2, BRCA1, BRCA2
39paraffin438.6BRCA2, BRCA1, ESR2, ERBB2
40h2o2438.5ERBB2, ESR2, BRCA1, BRCA2
41testosterone43 59 24 1211.5BRCA2, BRCA1, ESR2, ERBB2
42steroid438.5BRCA2, BRCA1, ESR2, ERBB2
43doxorubicin43 49 1210.5ABCC2, BRCA1, ESR2, ERBB2
44retinoic acid43 249.4ABCC2, BRCA2, BRCA1, ESR2
45etoposide43 49 59 1211.0ERBB2, ESR2, BRCA1, BRCA2, ABCC2
46tamoxifen43 49 28 1211.0ABCC2, BRCA2, BRCA1, ESR2, ERBB2
47genistein43 28 59 2 24 1213.0ERBB2, ESR2, BRCA1, BRCA2, ABCC2
48cycloheximide438.0ABCC2, BRCA2, BRCA1, ESR2, ERBB2
49progesterone43 28 59 24 1212.0ERBB2, ESR2, BRCA1, BRCA2, ABCC2
50estrogen438.0ERBB2, ESR2, BRCA1, BRCA2, ABCC2

GO Terms for genes affiliated with Fallopian Tube Cancer

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Cellular components related to Fallopian Tube Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00056548.7ESR2, BRCA1, BRCA2

Biological processes related to Fallopian Tube Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.6BRCA1, BRCA2
2double-strand break repair via homologous recombinationGO:00007249.4BRCA2, BRCA1
3response to estrogenGO:00436279.4BRCA1, ABCC2
4double-strand break repairGO:00063029.2BRCA1, BRCA2
5brain developmentGO:00074209.1ESR2, BRCA2

Molecular functions related to Fallopian Tube Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055157.5ERBB2, ESR2, BRCA1, BRCA2, ABCC2

Products for genes affiliated with Fallopian Tube Cancer

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  • Antibodies
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  • Proteins
  • Kits and Assays

Sources for Fallopian Tube Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet