MCID: FLL026
MIFTS: 56

Fallopian Tube Cancer malady

Rare diseases, Cancer diseases, Reproductive diseases, Nephrological diseases categories
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Summaries for Fallopian Tube Cancer

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Wikipedia:65 Primary fallopian tube cancer (PFTC), often just tubal cancer, is a malignant neoplasm that originates... more...

MalaCards based summary: Fallopian Tube Cancer, also known as fallopian tube carcinoma, is related to peritoneal carcinoma and breast cancer. An important gene associated with Fallopian Tube Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are Fanconi anemia pathway and DNA Repair. The compounds 8-oxoguanine and lycopene have been mentioned in the context of this disorder. Affiliated tissues include fallopian tube, breast and lymph node, and related mouse phenotypes are renal/urinary system and limbs/digits/tail.

Disease Ontology:8 A female reproductive organ cancer that is located in fallopian tube.

Aliases & Classifications for Fallopian Tube Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
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Fallopian Tube Cancer, Aliases & Descriptions:

Name: Fallopian Tube Cancer 8 42 10 44
Fallopian Tube Carcinoma 8 10 44 62
Cancer of the Fallopian Tube 8 42 62
Malignant Neoplasm of Uterine Tube 8 62
Malignant Tumor of Fallopian Tube 8 62
Carcinoma of Fallopian Tube 8 62
Tumor of the Fallopian Tube 8 62
Neoplasm of Fallopian Tube 8 62
Malignant Tumour of Fallopian Tube 8
 
Malignant Tumor of Fallopian Tubes 48
Tumor, Fallopian Tube, Malignant 8
Cancer of Fallopian Tubes 48
Fallopian Tube Neoplasms 62
Fallopian Tube Neoplasm 8
Renal Tubular Disorder 62
Malignant Tubal Tumor 48
Fallopian Tube Ca 8
Tubal Cancer 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
malignant tumor of fallopian tubes:
Prevalence: 1-9/100000


External Ids:

Disease Ontology8 DOID:1964, DOID:1963
MeSH34 D005185
NCIt39 C3032, C3867
ICD10 via Orphanet26 C57.0
UMLS via Orphanet63 C0153579
ICD1025 C57.0

Related Diseases for Fallopian Tube Cancer

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Diseases related to Fallopian Tube Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1peritoneal carcinoma30.9BRCA1, BRCA2
2breast cancer30.8BRCA2, BRCA1
3ovarian cancer30.0ERBB2, ESR2, BRCA1, BRCA2, ABCC2
4adenocarcinoma29.3ABCC2, BRCA2, BRCA1, ESR2, ERBB2
5peritonitis10.9
6familiar fallopian tube carcinoma10.4
7tuberculous salpingitis10.4
8breast-ovarian cancer, familial, 110.4BRCA2
9acromegaly10.4
10endometriosis10.4
11sarcoma10.4
12ollier disease10.4
13klippel-trenaunay syndrome10.3
14adenomatoid tumor10.3
15chronic salpingitis10.3
16salpingitis10.3
17malignant mixed mullerian tumor10.3
18germ cell tumors10.3
19ulceration of vulva10.3
20adenoma10.3
21arthropathy10.3
22tuberculosis10.3
23brca1 and brca2 hereditary breast and ovarian cancer10.2BRCA2, BRCA1
24muir-torre syndrome10.2
25nevoid basal cell carcinoma syndrome10.2
26proteus syndrome10.2
27werner syndrome10.2
28carney complex10.2
29pseudomyxoma peritonei10.2
30peutz-jeghers syndrome10.2
31desmoplastic small round cell tumor10.2
32hypertrichosis lanuginosa, acquired10.2
33polymyositis10.2
34turcot syndrome10.2
35schopf-schulz-passarge syndrome10.2
36cowden syndrome 110.2
37proteus syndrome, somatic10.2
38mosaic variegated aneuploidy syndrome 110.2
3946xy sex reversal 2, dosage-sensitive10.2
40primary peritoneal carcinoma10.2
41segmental outgrowth - lipomatosis - arteriovenous malformation - epidermal nevus10.2
42uterine carcinosarcoma10.2
43endocervicitis10.2
44dermatitis10.2
45fallopian tube adenocarcinoma10.2
46pelvic inflammatory disease10.2
47ectopic pregnancy10.2
48exfoliative dermatitis10.2
49bilateral breast cancer10.2BRCA2, BRCA1
50li-fraumeni syndrome10.2BRCA1, BRCA2

Graphical network of the top 20 diseases related to Fallopian Tube Cancer:



Diseases related to fallopian tube cancer

Symptoms for Fallopian Tube Cancer

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Drugs & Therapeutics for Fallopian Tube Cancer

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Drug clinical trials:

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Search NIH Clinical Center for Fallopian Tube Cancer

Genetic Tests for Fallopian Tube Cancer

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Anatomical Context for Fallopian Tube Cancer

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MalaCards organs/tissues related to Fallopian Tube Cancer:

32
Breast, Lymph node

FMA organs/tissues related to Fallopian Tube Cancer:

14
Fallopian tube

Animal Models for Fallopian Tube Cancer or affiliated genes

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Publications for Fallopian Tube Cancer

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Articles related to Fallopian Tube Cancer:

(show top 50)    (show all 80)
idTitleAuthorsYear
1
Surgical diagnosis of stage I fallopian tube cancer in anti-Yo antibody paraneoplastic cerebellar degeneration. (24960213)
2014
2
Paraneoplastic Neurological Syndrome in Fallopian Tube Cancer. (25364036)
2014
3
Cytoreduction of para-aortic lymph nodes behind the inferior vena cava and the right renal vessels in a patient with fallopian tube cancer. (24792999)
2014
4
MRP2 (ABCC2, cMOAT) expression in nuclear envelope of primary fallopian tube cancer cells is a new unfavorable prognostic factor. (23135210)
2013
5
Laparoscopic staging for apparent early stage ovarian or fallopian tube cancer. First case series from a UK cancer centre and systematic literature review. (23721765)
2013
6
Independent radiologic review of the Gynecologic Oncology Group Study 0218, a phase III trial of bevacizumab in the primary treatment of advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer. (23906656)
2013
7
Early detection of ovarian and fallopian tube cancer by examination of cytological samples from the endometrial cavity. (23868002)
2013
8
Increased incidence of severe gastrointestinal events with first-line paclitaxel, carboplatin, and vorinostat chemotherapy for advanced-stage epithelial ovarian, primary peritoneal, and fallopian tube cancer. (23385285)
2013
9
OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. (22529265)
2012
10
Outcome of single agent generic gemcitabine in platinum-resistant ovarian cancer, fallopian tube cancer and primary peritoneal adenocarcinoma. (22524817)
2012
11
Phase 1-2 study of docetaxel plus aflibercept in patients with recurrent ovarian, primary peritoneal, or fallopian tube cancer. (21992853)
2011
12
Para-aortic lymphadenectomy for primary fallopian tube cancer. (20887989)
2011
13
Junctional epithelial zones of the fallopian tube: cancer hotspots? (21131841)
2011
14
Asymptomatic primary fallopian tube cancer: an unusual cause of axillary lymphadenopathy. (22567506)
2011
15
Primary fallopian tube cancer in term pregnancy: a case report. (21614918)
2011
16
Combined weekly topotecan and biweekly bevacizumab in women with platinum-resistant ovarian, peritoneal, or fallopian tube cancer: results of a phase 2 study. (21815133)
2011
17
Clinical activity of gemcitabine plus pertuzumab in platinum-resistant ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. (19901115)
2010
18
Immunohistochemical findings in primary fallopian tube cancer. Case report. (20349798)
2010
19
Phase II evaluation of nanoparticle albumin-bound paclitaxel in platinum-sensitive patients with recurrent ovarian, peritoneal, or fallopian tube cancer. (19224848)
2009
20
High rates of occult fallopian tube cancer diagnosed at prophylactic bilateral salpingo-oophorectomy. (19574767)
2009
21
Incidence and management of pancreatic leaks after splenectomy with distal pancreatectomy performed during primary cytoreductive surgery for advanced ovarian, peritoneal and fallopian tube cancer. (19091388)
2009
22
Case report: Occurrence of fallopian tube cancer in a patient with previous history of estrogen receptor positive breast cancer. (20103847)
2009
23
A phase II study of cetuximab/paclitaxel/carboplatin for the initial treatment of advanced-stage ovarian, primary peritoneal, or fallopian tube cancer. (18554700)
2008
24
Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Consortia. (18423560)
2008
25
Fallopian tube cancer associated with paraneoplastic dermatomyositis -- asymptomatic multivisceral exacerbated dermatomyositis mimicking recurrent widespread malignant disease: case report. (18459555)
2008
26
Paclitaxel poliglumex and carboplatin as first-line therapy in ovarian, peritoneal or fallopian tube cancer: a phase I and feasibility trial of the Gynecologic Oncology Group. (18597837)
2008
27
Fallopian tube cancer: radical surgery, extended field radiation and chemotherapy in 24 personal cases treated with "intent to cure". (18973932)
2008
28
Second primary malignancies in females with primary fallopian tube cancer. (17266029)
2007
29
A phase II study of outpatient first-line paclitaxel, carboplatin, and bevacizumab for advanced-stage epithelial ovarian, peritoneal, and fallopian tube cancer. (17343605)
2007
30
Fallopian tube cancer: stepchild or mother? (18053873)
2007
31
The incidence of primary fallopian tube cancer in the United States. (17961642)
2007
32
A 10-year review of primary fallopian tube cancer at a community hospital: a high association of synchronous and metachronous cancers. (16445606)
2006
33
The founder mutation BRCA1c.2845insA identified in a fallopian tube cancer patient: a case report. (16515624)
2006
34
The significance of Doppler flow and anamnesis in the diagnosis of fallopian tube cancer. (15991534)
2005
35
A phase II trial of weekly docetaxel in patients with platinum-resistant epithelial ovarian, primary peritoneal serous cancer, or fallopian tube cancer. (15581974)
2004
36
Phase 2 trial of interferon-beta as second-line treatment of ovarian cancer, fallopian tube cancer, or primary carcinoma of the peritoneum. (15331919)
2004
37
Primary fallopian tube cancer--a ten year review. Clinicopathological study of 12 cases. (15285322)
2004
38
Phase 2 trial of single agent docetaxel in platinum and paclitaxel-refractory ovarian cancer, fallopian tube cancer, and primary carcinoma of the peritoneum. (14675679)
2003
39
Preoperative diagnosis of fallopian tube cancer by imaging. (14628888)
2003
40
Molecular evidence for putative tumour suppressor genes on chromosome 13q specific to BRCA1 related ovarian and fallopian tube cancer. (12354934)
2002
41
Long-term survival of a patient with fallopian tube cancer presenting with a supraclavicular mass. (11205221)
2000
42
Fallopian tube cancer as a feature of BRCA1-associated syndromes. (10926816)
2000
43
Practice guidelines: fallopian tube cancer. Society of Gynecologic Oncologists Clinical Practice Guidelines. (9507528)
1998
44
Primary fallopian tube cancer: a review of the literature. (9643524)
1998
45
Fallopian tube cancer: incidence and role of lymphatic spread. (8751549)
1996
46
DNA-ploidy and mutant p53 overexpression in primary fallopian tube cancer. (11578443)
1994
47
Fallopian tube cancer metastatic to the breast. (8005136)
1994
48
Staging rules for gestational trophoblastic tumors and fallopian tube cancer. (1317647)
1992
49
Fallopian tube cancer. The Roswell Park experience. (2249208)
1990
50
Immunolymphoscintigraphy and immunoscintigraphy of ovarian and fallopian tube cancer using F(ab')2 fragments of monoclonal antibody OC 125. (2297745)
1990

Variations for Fallopian Tube Cancer

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Expression for genes affiliated with Fallopian Tube Cancer

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Expression patterns in normal tissues for genes affiliated with Fallopian Tube Cancer

Search GEO for disease gene expression data for Fallopian Tube Cancer.

Pathways for genes affiliated with Fallopian Tube Cancer

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Pathways related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5BRCA2, BRCA1
2
Show member pathways
9.5BRCA1, BRCA2
3
Show member pathways
9.5BRCA1, BRCA2
49.5BRCA2, BRCA1
59.5BRCA1, BRCA2
6
Show member pathways
9.5BRCA1, BRCA2
7
Show member pathways
9.5BRCA1, BRCA2
8
Show member pathways
9.5BRCA2, BRCA1
99.5ERBB2, BRCA1
10
Show member pathways
9.4BRCA2, ERBB2
11
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.1ERBB2, ESR2
12
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.1ESR2, ERBB2
13
Show member pathways
Signaling Pathways in Glioblastoma37
9.0ERBB2, BRCA1, BRCA2
14
Show member pathways
8.7BRCA2, BRCA1, ESR2
15
Show member pathways
8.7ERBB2, ESR2, BRCA1
168.2ERBB2, ESR2, BRCA1, BRCA2
17
Show member pathways
8.2ERBB2, ESR2, BRCA1, BRCA2

Compounds for genes affiliated with Fallopian Tube Cancer

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Compounds related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
18-oxoguanine449.8BRCA1, BRCA2
2lycopene44 2410.8BRCA2, BRCA1
3vinorelbine44 50 1111.8BRCA1, ERBB2
4indole-3-carbinol449.6BRCA1, BRCA2
5sunitinib44 50 1111.6ABCC2, ERBB2
6methylmethanesulfonate449.6BRCA1, BRCA2
7platinum44 5010.6BRCA1, ABCC2
8taxane449.6ABCC2, ERBB2
9anastrozole44 50 1111.5ESR2, ERBB2
10exemestane44 50 61 1112.5ESR2, ERBB2
11toremifene44 1110.4ERBB2, ESR2
12fulvestrant44 50 28 1112.4ESR2, ERBB2
13mitoxantrone44 50 1111.4ABCC2, ERBB2
14letrozole44 50 61 1112.4ESR2, ERBB2
15p002449.3BRCA2, BRCA1, ERBB2
16carbamazepine44 50 1111.3ERBB2, ABCC2
17topotecan44 1110.3ERBB2, BRCA1, ABCC2
18oxaliplatin44 50 1111.3ERBB2, BRCA1, ABCC2
19carboplatin44 50 1111.3ABCC2, BRCA1, ERBB2
20mitomycin c449.3BRCA1, BRCA2, ABCC2
21vincristine44 50 1111.3BRCA1, BRCA2, ABCC2
22camptothecin44 61 1111.2BRCA1, BRCA2, ABCC2
23leucovorin44 50 1111.2ERBB2, ABCC2
245fluorouracil449.2ERBB2, BRCA1, ABCC2
2517beta-hydroxysteroid449.2ESR2, BRCA1
26daidzein449.1ESR2, BRCA1, BRCA2
27thymidylate449.1BRCA1, ESR2, ERBB2
28estradiol44 24 1110.9BRCA2, BRCA1, ESR2
29egcg448.9ABCC2, ESR2, ERBB2
30raloxifene44 50 28 1111.8ERBB2, ESR2
31adriamycin448.8ABCC2, BRCA2, BRCA1, ERBB2
32docetaxel44 50 61 1111.8ABCC2, BRCA2, BRCA1, ERBB2
33folate448.8ABCC2, BRCA2, BRCA1, ERBB2
34methotrexate50 44 1110.8ABCC2, BRCA2, BRCA1, ERBB2
35paclitaxel44 50 1110.8ABCC2, BRCA2, BRCA1, ERBB2
36cisplatin44 50 61 1111.8ABCC2, BRCA2, BRCA1, ERBB2
374-hydroxytamoxifen448.6BRCA2, BRCA1, ESR2, ERBB2
38resveratrol44 61 24 1111.6ERBB2, ESR2, BRCA1, BRCA2
39paraffin448.6BRCA2, BRCA1, ESR2, ERBB2
40h2o2448.5ERBB2, ESR2, BRCA1, BRCA2
41testosterone44 61 24 1111.5BRCA2, BRCA1, ESR2, ERBB2
42steroid448.5BRCA2, BRCA1, ESR2, ERBB2
43doxorubicin44 50 1110.5ABCC2, BRCA1, ESR2, ERBB2
44retinoic acid44 249.4ABCC2, BRCA2, BRCA1, ESR2
45etoposide44 50 61 1111.0ERBB2, ESR2, BRCA1, BRCA2, ABCC2
46tamoxifen44 50 28 1111.0ABCC2, BRCA2, BRCA1, ESR2, ERBB2
47genistein44 28 61 2 24 1113.0ERBB2, ESR2, BRCA1, BRCA2, ABCC2
48cycloheximide448.0ABCC2, BRCA2, BRCA1, ESR2, ERBB2
49progesterone44 28 61 24 1112.0ERBB2, ESR2, BRCA1, BRCA2, ABCC2
50estrogen448.0ERBB2, ESR2, BRCA1, BRCA2, ABCC2

GO Terms for genes affiliated with Fallopian Tube Cancer

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Cellular components related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.7ESR2, BRCA1, BRCA2

Biological processes related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.6BRCA1, BRCA2
2double-strand break repair via homologous recombinationGO:0007249.4BRCA2, BRCA1
3response to estrogenGO:0436279.4BRCA1, ABCC2
4double-strand break repairGO:0063029.2BRCA1, BRCA2
5brain developmentGO:0074209.1ESR2, BRCA2

Molecular functions related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.5ERBB2, ESR2, BRCA1, BRCA2, ABCC2

Products for genes affiliated with Fallopian Tube Cancer

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  • Antibodies
  • Proteins
  • Lysates

Sources for Fallopian Tube Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet