MCID: FLL026
MIFTS: 53

Fallopian Tube Cancer malady

Rare diseases, Cancer diseases, Reproductive diseases, Nephrological diseases categories
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Summaries for Fallopian Tube Cancer

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Primary fallopian tube cancer (PFTC), often just tubal cancer, is a malignant neoplasm that originates... more...

MalaCards: Fallopian Tube Cancer, also known as fallopian tube carcinoma, is related to ovarian cancer and peritoneal carcinoma. An important gene associated with Fallopian Tube Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are Fanconi anemia pathway and DNA Repair. The compounds 8-oxoguanine and lycopene have been mentioned in the context of this disorder. Affiliated tissues include fallopian tube and breast, and related mouse phenotypes are renal/urinary system and limbs/digits/tail.

Disease Ontology:8 A female reproductive organ cancer that is located in fallopian tube.

Aliases & Classifications for Fallopian Tube Cancer

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Classifications:



Aliases & Descriptions:

fallopian tube cancer 8 43 10 45
fallopian tube carcinoma 8 10 45 62
cancer of the fallopian tube 8 43
malignant neoplasm of uterine tube 8
malignant tumour of fallopian tube 8
malignant tumor of fallopian tube 8
tumor, fallopian tube, malignant 8
carcinoma of fallopian tube 8
tumor of the fallopian tube 8
neoplasm of fallopian tube 8
fallopian tube neoplasms 62
fallopian tube neoplasm 8
renal tubular disorder 62
fallopian tube ca 8


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Disease Ontology8 DOID:1964, DOID:1963
MeSH35 D005185
NCIt40 C3032, C3867
ICD1025 C57.0

Related Diseases for Fallopian Tube Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Fallopian Tube Cancer family:

Fallopian Tube Benign Neoplasm

Diseases related to Fallopian Tube Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian cancer30.7ERBB2, ESR2, BRCA1, BRCA2, ABCC2
2peritoneal carcinoma30.7BRCA1, BRCA2
3breast cancer30.6BRCA2, BRCA1
4adenocarcinoma30.0ABCC2, BRCA2, BRCA1, ESR2, ERBB2
5peritonitis10.8
6familiar fallopian tube carcinoma10.4
7tuberculous salpingitis10.4
8acromegaly10.4
9ovarian endometriosis10.4
10endometriosis10.4
11sarcoma10.4
12ollier disease10.4
13fallopian tube carcinosarcoma10.3
14klippel-trenaunay syndrome10.3
15adenomatoid tumor10.3
16chronic salpingitis10.3
17salpingitis10.3
18malignant germ cell tumor10.3
19malignant mixed mullerian tumor10.3
20germ cell tumors10.3
21ulceration of vulva10.2
22adenoma10.2
23arthropathy10.2
24tuberculosis10.2
25proteus syndrome10.2
26carney complex10.2
27muir-torre syndrome10.2
28werner syndrome10.2
29pseudomyxoma peritonei10.2
30peutz-jeghers syndrome10.2
31desmoplastic small round cell tumor10.2
32hypertrichosis lanuginosa, acquired10.2
33polymyositis10.2
34turcot syndrome10.2
35schopf-schulz-passarge syndrome10.2
36colorectal cancer, hereditary nonpolyposis, type 110.2
3746xy sex reversal 310.2
38proteus syndrome, somatic10.2
39mosaic variegated aneuploidy syndrome 110.2
40primary peritoneal carcinoma10.2
41segmental outgrowth - lipomatosis - arteriovenous malformation - epidermal nevus10.2
42endocervicitis10.2
43dermatitis10.2
44pelvic inflammatory disease10.2
45ectopic pregnancy10.2
46exfoliative dermatitis10.2
47estrogen-receptor positive breast cancer10.2
48inflammatory breast carcinoma10.2
49dermatomyositis10.2
50pancreatitis10.2

Graphical network of the top 20 diseases related to Fallopian Tube Cancer:



Diseases related to fallopian tube cancer

Symptoms for Fallopian Tube Cancer

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Drugs & Therapeutics for Fallopian Tube Cancer

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Fallopian Tube Cancer

Search NIH Clinical Center for Fallopian Tube Cancer

Genetic Tests for Fallopian Tube Cancer

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Anatomical Context for Fallopian Tube Cancer

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Fallopian Tube Cancer:

33
Breast

FMA organs/tissues related to Fallopian Tube Cancer:

14
Fallopian tube

Animal Models for Fallopian Tube Cancer or affiliated genes

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Sources:
37MGI
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Publications for Fallopian Tube Cancer

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Sources:
52PubMed
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Articles related to Fallopian Tube Cancer:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
MRP2 (ABCC2, cMOAT) expression in nuclear envelope of primary fallopian tube cancer cells is a new unfavorable prognostic factor. (23135210)
2013
2
Laparoscopic staging for apparent early stage ovarian or fallopian tube cancer. First case series from a UK cancer centre and systematic literature review. (23721765)
2013
3
Independent radiologic review of the Gynecologic Oncology Group Study 0218, a phase III trial of bevacizumab in the primary treatment of advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer. (23906656)
2013
4
Early detection of ovarian and fallopian tube cancer by examination of cytological samples from the endometrial cavity. (23868002)
2013
5
Increased incidence of severe gastrointestinal events with first-line paclitaxel, carboplatin, and vorinostat chemotherapy for advanced-stage epithelial ovarian, primary peritoneal, and fallopian tube cancer. (23385285)
2013
6
OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. (22529265)
2012
7
Outcome of single agent generic gemcitabine in platinum-resistant ovarian cancer, fallopian tube cancer and primary peritoneal adenocarcinoma. (22524817)
2012
8
Phase 1-2 study of docetaxel plus aflibercept in patients with recurrent ovarian, primary peritoneal, or fallopian tube cancer. (21992853)
2011
9
Para-aortic lymphadenectomy for primary fallopian tube cancer. (20887989)
2011
10
Junctional epithelial zones of the fallopian tube: cancer hotspots? (21131841)
2011
11
Asymptomatic primary fallopian tube cancer: an unusual cause of axillary lymphadenopathy. (22567506)
2011
12
Primary fallopian tube cancer in term pregnancy: a case report. (21614918)
2011
13
Combined weekly topotecan and biweekly bevacizumab in women with platinum-resistant ovarian, peritoneal, or fallopian tube cancer: results of a phase 2 study. (21815133)
2011
14
Clinical activity of gemcitabine plus pertuzumab in platinum-resistant ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. (19901115)
2010
15
Immunohistochemical findings in primary fallopian tube cancer. Case report. (20349798)
2010
16
Phase II evaluation of nanoparticle albumin-bound paclitaxel in platinum-sensitive patients with recurrent ovarian, peritoneal, or fallopian tube cancer. (19224848)
2009
17
High rates of occult fallopian tube cancer diagnosed at prophylactic bilateral salpingo-oophorectomy. (19574767)
2009
18
Incidence and management of pancreatic leaks after splenectomy with distal pancreatectomy performed during primary cytoreductive surgery for advanced ovarian, peritoneal and fallopian tube cancer. (19091388)
2009
19
Case report: Occurrence of fallopian tube cancer in a patient with previous history of estrogen receptor positive breast cancer. (20103847)
2009
20
A phase II study of cetuximab/paclitaxel/carboplatin for the initial treatment of advanced-stage ovarian, primary peritoneal, or fallopian tube cancer. (18554700)
2008
21
Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Consortia. (18423560)
2008
22
Fallopian tube cancer associated with paraneoplastic dermatomyositis -- asymptomatic multivisceral exacerbated dermatomyositis mimicking recurrent widespread malignant disease: case report. (18459555)
2008
23
Paclitaxel poliglumex and carboplatin as first-line therapy in ovarian, peritoneal or fallopian tube cancer: a phase I and feasibility trial of the Gynecologic Oncology Group. (18597837)
2008
24
Fallopian tube cancer: radical surgery, extended field radiation and chemotherapy in 24 personal cases treated with "intent to cure". (18973932)
2008
25
Second primary malignancies in females with primary fallopian tube cancer. (17266029)
2007
26
A phase II study of outpatient first-line paclitaxel, carboplatin, and bevacizumab for advanced-stage epithelial ovarian, peritoneal, and fallopian tube cancer. (17343605)
2007
27
Fallopian tube cancer: stepchild or mother? (18053873)
2007
28
The incidence of primary fallopian tube cancer in the United States. (17961642)
2007
29
A 10-year review of primary fallopian tube cancer at a community hospital: a high association of synchronous and metachronous cancers. (16445606)
2006
30
The founder mutation BRCA1c.2845insA identified in a fallopian tube cancer patient: a case report. (16515624)
2006
31
The significance of Doppler flow and anamnesis in the diagnosis of fallopian tube cancer. (15991534)
2005
32
A phase II trial of weekly docetaxel in patients with platinum-resistant epithelial ovarian, primary peritoneal serous cancer, or fallopian tube cancer. (15581974)
2004
33
Phase 2 trial of interferon-beta as second-line treatment of ovarian cancer, fallopian tube cancer, or primary carcinoma of the peritoneum. (15331919)
2004
34
Primary fallopian tube cancer--a ten year review. Clinicopathological study of 12 cases. (15285322)
2004
35
Phase 2 trial of single agent docetaxel in platinum and paclitaxel-refractory ovarian cancer, fallopian tube cancer, and primary carcinoma of the peritoneum. (14675679)
2003
36
Preoperative diagnosis of fallopian tube cancer by imaging. (14628888)
2003
37
Molecular evidence for putative tumour suppressor genes on chromosome 13q specific to BRCA1 related ovarian and fallopian tube cancer. (12354934)
2002
38
Fallopian tube cancer in a BRCA1 mutation carrier: rapid development and failure of screening. (11810084)
2002
39
Long-term survival of a patient with fallopian tube cancer presenting with a supraclavicular mass. (11205221)
2000
40
Fallopian tube cancer as a feature of BRCA1-associated syndromes. (10926816)
2000
41
Treatment of fallopian tube cancer. Review of the literature. (10985612)
2000
42
Practice guidelines: fallopian tube cancer. Society of Gynecologic Oncologists Clinical Practice Guidelines. (9507528)
1998
43
Primary fallopian tube cancer: a review of the literature. (9643524)
1998
44
Fallopian tube cancer: incidence and role of lymphatic spread. (8751549)
1996
45
DNA-ploidy and mutant p53 overexpression in primary fallopian tube cancer. (11578443)
1994
46
Fallopian tube cancer metastatic to the breast. (8005136)
1994
47
Staging rules for gestational trophoblastic tumors and fallopian tube cancer. (1317647)
1992
48
Fallopian tube cancer. The Roswell Park experience. (2249208)
1990
49
Immunolymphoscintigraphy and immunoscintigraphy of ovarian and fallopian tube cancer using F(ab')2 fragments of monoclonal antibody OC 125. (2297745)
1990
50
Fallopian tube cancer. (3189120)
1988

Variations for Fallopian Tube Cancer

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Expression for genes affiliated with Fallopian Tube Cancer

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fallopian Tube Cancer

Search GEO for disease gene expression data for Fallopian Tube Cancer.

Pathways for genes affiliated with Fallopian Tube Cancer

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Sources:
50PathCards, 30KEGG, 55Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN
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Pathways related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5BRCA2, BRCA1
2
Show member pathways
9.5BRCA1, BRCA2
3
Show member pathways
9.5BRCA1, BRCA2
49.5BRCA2, BRCA1
59.5BRCA1, BRCA2
6
Show member pathways
9.5BRCA1, BRCA2
7
Show member pathways
9.5BRCA1, BRCA2
8
Show member pathways
9.5BRCA2, BRCA1
99.5ERBB2, BRCA1
10
Show member pathways
9.4BRCA2, ERBB2
11
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.1ERBB2, ESR2
12
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.1ESR2, ERBB2
13
Show member pathways
Signaling Pathways in Glioblastoma38
9.0ERBB2, BRCA1, BRCA2
14
Show member pathways
8.7BRCA2, BRCA1, ESR2
15
Show member pathways
8.7ERBB2, ESR2, BRCA1
168.2ERBB2, ESR2, BRCA1, BRCA2
17
Show member pathways
8.2ERBB2, ESR2, BRCA1, BRCA2

Compounds for genes affiliated with Fallopian Tube Cancer

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Sources:
45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
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Compounds related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
18-oxoguanine459.8BRCA1, BRCA2
2lycopene45 2410.8BRCA2, BRCA1
3vinorelbine45 51 1111.8BRCA1, ERBB2
4indole-3-carbinol459.6BRCA1, BRCA2
5sunitinib45 51 1111.6ABCC2, ERBB2
6methylmethanesulfonate459.6BRCA1, BRCA2
7platinum45 5110.6BRCA1, ABCC2
8taxane459.6ABCC2, ERBB2
9anastrozole45 51 1111.5ESR2, ERBB2
10exemestane45 51 61 1112.5ESR2, ERBB2
11toremifene45 1110.4ERBB2, ESR2
12fulvestrant45 51 29 1112.4ESR2, ERBB2
13mitoxantrone45 51 1111.4ABCC2, ERBB2
14letrozole45 51 61 1112.4ESR2, ERBB2
15p002459.3BRCA2, BRCA1, ERBB2
16carbamazepine45 51 1111.3ERBB2, ABCC2
17topotecan45 1110.3ERBB2, BRCA1, ABCC2
18oxaliplatin45 51 1111.3ERBB2, BRCA1, ABCC2
19carboplatin45 51 1111.3ABCC2, BRCA1, ERBB2
20mitomycin c459.3BRCA1, BRCA2, ABCC2
21vincristine45 51 1111.3BRCA1, BRCA2, ABCC2
22camptothecin45 61 1111.2BRCA1, BRCA2, ABCC2
23leucovorin45 51 1111.2ERBB2, ABCC2
245fluorouracil459.2ERBB2, BRCA1, ABCC2
2517beta-hydroxysteroid459.2ESR2, BRCA1
26daidzein459.1ESR2, BRCA1, BRCA2
27thymidylate459.1BRCA1, ESR2, ERBB2
28estradiol45 24 1110.9BRCA2, BRCA1, ESR2
29egcg458.9ABCC2, ESR2, ERBB2
30raloxifene45 51 29 1111.8ERBB2, ESR2
31adriamycin458.8ABCC2, BRCA2, BRCA1, ERBB2
32docetaxel45 51 61 1111.8ABCC2, BRCA2, BRCA1, ERBB2
33folate458.8ABCC2, BRCA2, BRCA1, ERBB2
34methotrexate51 45 1110.8ABCC2, BRCA2, BRCA1, ERBB2
35paclitaxel45 51 1110.8ABCC2, BRCA2, BRCA1, ERBB2
36cisplatin45 51 61 1111.8ABCC2, BRCA2, BRCA1, ERBB2
374-hydroxytamoxifen458.6BRCA2, BRCA1, ESR2, ERBB2
38resveratrol45 61 24 1111.6ERBB2, ESR2, BRCA1, BRCA2
39paraffin458.6BRCA2, BRCA1, ESR2, ERBB2
40h2o2458.5ERBB2, ESR2, BRCA1, BRCA2
41testosterone45 61 24 1111.5BRCA2, BRCA1, ESR2, ERBB2
42steroid458.5BRCA2, BRCA1, ESR2, ERBB2
43doxorubicin45 51 1110.5ABCC2, BRCA1, ESR2, ERBB2
44retinoic acid45 249.4ABCC2, BRCA2, BRCA1, ESR2
45etoposide45 51 61 1111.0ERBB2, ESR2, BRCA1, BRCA2, ABCC2
46tamoxifen45 51 29 1111.0ABCC2, BRCA2, BRCA1, ESR2, ERBB2
47genistein45 29 61 3 24 1113.0ERBB2, ESR2, BRCA1, BRCA2, ABCC2
48cycloheximide458.0ABCC2, BRCA2, BRCA1, ESR2, ERBB2
49progesterone45 29 61 24 1112.0ERBB2, ESR2, BRCA1, BRCA2, ABCC2
50estrogen458.0ERBB2, ESR2, BRCA1, BRCA2, ABCC2

GO Terms for genes affiliated with Fallopian Tube Cancer

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16Gene Ontology
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Cellular components related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.7ESR2, BRCA1, BRCA2

Biological processes related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.6BRCA1, BRCA2
2double-strand break repair via homologous recombinationGO:0007249.4BRCA2, BRCA1
3response to estrogenGO:0436279.4BRCA1, ABCC2
4double-strand break repairGO:0063029.2BRCA1, BRCA2
5brain developmentGO:0074209.1ESR2, BRCA2

Molecular functions related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.5ERBB2, ESR2, BRCA1, BRCA2, ABCC2

Products for genes affiliated with Fallopian Tube Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fallopian Tube Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet