MCID: FLL026
MIFTS: 52

Fallopian Tube Cancer malady

Cancer diseases, Reproductive diseases, Nephrological diseases categories

Summaries for Fallopian Tube Cancer

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Primary fallopian tube cancer (PFTC), often just tubal cancer, is a malignant neoplasm that originates... more...

MalaCards: Fallopian Tube Cancer, also known as fallopian tube carcinoma, is related to ovarian cancer and breast cancer. An important gene associated with Fallopian Tube Cancer is BRCA1 (breast cancer 1, early onset), and among its related pathways are Fanconi anemia pathway and BRCA1 Pathway. The compounds adriamycin and 8-oxoguanine have been mentioned in the context of this disorder. Affiliated tissues include fallopian tube, breast and ovary, and related mouse phenotypes are limbs/digits/tail and integument.

Disease Ontology:8 A female reproductive organ cancer that is located in fallopian tube.

Aliases & Classifications for Fallopian Tube Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases, Nephrological diseases


Aliases & Descriptions:

fallopian tube cancer 8 42 10 44
fallopian tube carcinoma 8 10 44 60
cancer of the fallopian tube 8 42
malignant neoplasm of uterine tube 8
malignant tumour of fallopian tube 8
malignant tumor of fallopian tube 8
tumor, fallopian tube, malignant 8
tumor of the fallopian tube 8
carcinoma of fallopian tube 8
neoplasm of fallopian tube 8
fallopian tube neoplasms 60
fallopian tube neoplasm 8
renal tubular disorder 60
fallopian tube ca 8


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Disease Ontology8 DOID:1964, DOID:1963
NCIt39 C3032, C3867
MeSH34 D005185
ICD1025 C57.0

Related Diseases for Fallopian Tube Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Fallopian Tube Cancer family:

Fallopian Tube Benign Neoplasm

Diseases related to Fallopian Tube Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian cancer31.2BRCA1, BRCA2, ESR2, ABCC2, ERBB2
2breast cancer30.7ERBB2, ABCC2, ESR2, BRCA2, BRCA1
3endometriosis30.5ESR2
4sarcoma30.5BRCA2
5adenoma30.3ESR2, BRCA1
6papillary carcinoma30.2ERBB2, BRCA2
7pancreatitis30.2BRCA2
8pancreatic cancer30.2ESR2, BRCA2
9adenocarcinoma30.1ERBB2, BRCA1, ESR2, BRCA2, ABCC2
10peritonitis10.8
11familiar fallopian tube carcinoma10.4
12tuberculous salpingitis10.4
13cervix endometriosis10.3
14fallopian tube endometriosis10.3
15ovarian endometriosis10.3
16endometriosis of ovary10.3
17acromegaly10.3
18ovarian cyst10.3
19ovary sarcoma10.3
20ollier disease10.3
21peritoneum cancer10.3
22fallopian tube carcinosarcoma10.2
23fallopian tube adenomatoid tumor10.2
24klippel-trenaunay syndrome10.2
25adenomatoid tumor10.2
26chronic salpingitis10.2
27salpingitis10.2
28pregnancy adenoma10.2
29ovary papillary carcinoma10.2
30ulceration of vulva10.2
31papillary adenoma10.2
32arthropathy10.2
33endometriosis of uterus10.2
34liver sarcoma10.2
35retroperitoneal sarcoma10.2
36tuberculosis10.2
37proteus syndrome10.2
38carney complex10.2
39muir-torre syndrome10.2
40werner syndrome10.2
41pseudomyxoma peritonei10.2
42turcot syndrome10.2
43desmoplastic small round cell tumor10.2
44hypertrichosis lanuginosa, acquired10.2
45polymyositis10.2
46schopf-schulz-passarge syndrome10.2
4746xy sex reversal 310.2
48proteus syndrome, somatic10.2
49mosaic variegated aneuploidy syndrome 110.2
50primary peritoneal carcinoma10.2

Graphical network of the top 20 diseases related to Fallopian Tube Cancer:



Diseases related to fallopian tube cancer

Clinical Features for Fallopian Tube Cancer

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Drugs & Therapeutics for Fallopian Tube Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Fallopian Tube Cancer

Drug clinical trials:

Search ClinicalTrials for Fallopian Tube Cancer

Search NIH Clinical Center for Fallopian Tube Cancer

Search CenterWatch for Fallopian Tube Cancer

Genetic Tests for Fallopian Tube Cancer

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Anatomical Context for Fallopian Tube Cancer

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Fallopian Tube Cancer:

32
Breast, Ovary, Brain, Endothelial

FMA organs/tissues related to Fallopian Tube Cancer:

14
Fallopian tube

Animal Models for Fallopian Tube Cancer or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Fallopian Tube Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.2BRCA2
2MP:00107719.4BRCA2, BRCA1
3MP:00053799.0BRCA1, BRCA2, ESR2
4MP:00053898.9ERBB2, BRCA2, BRCA1
5MP:00020068.5ESR2, ERBB2, BRCA2, BRCA1
6MP:00053818.5BRCA1, BRCA2, ERBB2, ESR2
7MP:00053908.4ESR2, ERBB2, BRCA2, BRCA1
8MP:00028738.1BRCA1, BRCA2, ERBB2, ESR2
9MP:00053767.6ESR2, ERBB2, ABCC2, BRCA2, BRCA1

Publications for Fallopian Tube Cancer

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Sources:
50PubMed
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Articles related to Fallopian Tube Cancer:

(show top 50)    (show all 89)
idTitleAuthorsYear
1
Revisiting the pathogenesis of ovarian cancer: the central role of the fallopian tube. (24100801)
2014
2
Laparoscopic staging for apparent early stage ovarian or fallopian tube cancer. First case series from a UK cancer centre and systematic literature review. (23721765)
2013
3
Independent radiologic review of the Gynecologic Oncology Group Study 0218, a phase III trial of bevacizumab in the primary treatment of advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer. (23906656)
2013
4
Increased incidence of severe gastrointestinal events with first-line paclitaxel, carboplatin, and vorinostat chemotherapy for advanced-stage epithelial ovarian, primary peritoneal, and fallopian tube cancer. (23385285)
2013
5
Phase 1-2 study of docetaxel plus aflibercept in patients with recurrent ovarian, primary peritoneal, or fallopian tube cancer. (21992853)
2011
6
Junctional epithelial zones of the fallopian tube: cancer hotspots? (21131841)
2011
7
Asymptomatic primary fallopian tube cancer: an unusual cause of axillary lymphadenopathy. (22567506)
2011
8
Primary fallopian tube cancer in term pregnancy: a case report. (21614918)
2011
9
Phase II trial of intraperitoneal cisplatin combined with intravenous paclitaxel in patients with ovarian, primary peritoneal and fallopian tube cancer. (21664657)
2011
10
Unexpected gastrointestinal toxicity from Docetaxel/Carboplatin/Erlotinib followed by maintenance Erlotinib treatment for newly diagnosed stage III/IV ovarian cancer, primary peritoneal, or fallopian tube cancer. (21324515)
2011
11
Clinical activity of gemcitabine plus pertuzumab in platinum-resistant ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. (19901115)
2010
12
Immunohistochemical findings in primary fallopian tube cancer. Case report. (20349798)
2010
13
Cancer-associated retinopathy in neuroendocrine carcinoma of the fallopian tube. (20724944)
2010
14
Incidence and management of pancreatic leaks after splenectomy with distal pancreatectomy performed during primary cytoreductive surgery for advanced ovarian, peritoneal and fallopian tube cancer. (19091388)
2009
15
Case report: Occurrence of fallopian tube cancer in a patient with previous history of estrogen receptor positive breast cancer. (20103847)
2009
16
Systematic lymphadenectomy improves survival in patients with advanced-stage primary fallopian tube cancer. (19398867)
2009
17
Liquid-based cytology aids in primary fallopian tube cancer diagnosis. (19650204)
2009
18
Fallopian tube cancer presenting as inflammatory breast carcinoma: report of a case and review of the literature. (19899419)
2009
19
Validation of epithelial ovarian cancer and fallopian tube cancer and ovarian borderline tumor data in the Danish Gynecological Cancer Database. (19308749)
2009
20
A phase II study of cetuximab/paclitaxel/carboplatin for the initial treatment of advanced-stage ovarian, primary peritoneal, or fallopian tube cancer. (18554700)
2008
21
Fallopian tube cancer associated with paraneoplastic dermatomyositis -- asymptomatic multivisceral exacerbated dermatomyositis mimicking recurrent widespread malignant disease: case report. (18459555)
2008
22
Synchronous occult cancers of the endometrium and fallopian tube in an MSH2 mutation carrier at time of prophylactic surgery. (18805575)
2008
23
Paclitaxel poliglumex and carboplatin as first-line therapy in ovarian, peritoneal or fallopian tube cancer: a phase I and feasibility trial of the Gynecologic Oncology Group. (18597837)
2008
24
Fallopian tube cancer: radical surgery, extended field radiation and chemotherapy in 24 personal cases treated with "intent to cure". (18973932)
2008
25
Occult fallopian tube cancer in a patient with BRCA1 breast cancer. (18971141)
2008
26
Second primary malignancies in females with primary fallopian tube cancer. (17266029)
2007
27
Fallopian tube cancer: stepchild or mother? (18053873)
2007
28
Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction. (17761984)
2007
29
Effect of perioperative venous thromboembolism on survival in ovarian, primary peritoneal, and fallopian tube cancer. (17614125)
2007
30
Phenotypic variability of a 4q34-->qter inherited deletion: MRKH syndrome in the daughter, cardiac defect and Fallopian tube cancer in the mother. (17081814)
2007
31
Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 Mutation. (16835424)
2006
32
The founder mutation BRCA1c.2845insA identified in a fallopian tube cancer patient: a case report. (16515624)
2006
33
The significance of Doppler flow and anamnesis in the diagnosis of fallopian tube cancer. (15991534)
2005
34
A phase II trial of weekly docetaxel in patients with platinum-resistant epithelial ovarian, primary peritoneal serous cancer, or fallopian tube cancer. (15581974)
2004
35
Occult cancer of the fallopian tube in a BRCA2 germline mutation carrier at prophylactic salpingo-oophorectomy. (14984974)
2004
36
Primary fallopian tube cancer--a ten year review. Clinicopathological study of 12 cases. (15285322)
2004
37
Pilot study of outpatient paclitaxel, carboplatin and gemcitabine for advanced stage epithelial ovarian, peritoneal, and fallopian tube cancer. (15350364)
2004
38
Phase 2 trial of single agent docetaxel in platinum and paclitaxel-refractory ovarian cancer, fallopian tube cancer, and primary carcinoma of the peritoneum. (14675679)
2003
39
Preoperative diagnosis of fallopian tube cancer by imaging. (14628888)
2003
40
Molecular evidence for putative tumour suppressor genes on chromosome 13q specific to BRCA1 related ovarian and fallopian tube cancer. (12354934)
2002
41
Fallopian tube cancer in a BRCA1 mutation carrier: rapid development and failure of screening. (11810084)
2002
42
Occult cancer of the fallopian tube in BRCA-1 germline mutation carriers at prophylactic oophorectomy: a case for recommending hysterectomy at surgical prophylaxis. (11161856)
2001
43
Fallopian tube cancer as a feature of BRCA1-associated syndromes. (10926816)
2000
44
Practice guidelines: fallopian tube cancer. Society of Gynecologic Oncologists Clinical Practice Guidelines. (9507528)
1998
45
Primary fallopian tube cancer: a review of the literature. (9643524)
1998
46
DNA-ploidy and mutant p53 overexpression in primary fallopian tube cancer. (11578443)
1994
47
Staging rules for gestational trophoblastic tumors and fallopian tube cancer. (1317647)
1992
48
Fallopian tube cancer. The Roswell Park experience. (2249208)
1990
49
Immunolymphoscintigraphy and immunoscintigraphy of ovarian and fallopian tube cancer using F(ab')2 fragments of monoclonal antibody OC 125. (2297745)
1990
50
Fallopian tube cancer: the role of radiation therapy. (3444903)
1987

Genetic Variations for Fallopian Tube Cancer

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Expression for genes affiliated with Fallopian Tube Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fallopian Tube Cancer

Search GEO for disease gene expression data for Fallopian Tube Cancer.

Pathways for genes affiliated with Fallopian Tube Cancer

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Sources:
29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Fallopian Tube Cancer

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1adriamycin4410.1ABCC2
28-oxoguanine449.8BRCA1, BRCA2
3lycopene44 2410.8BRCA1, BRCA2
4h2o2449.7ESR2, ERBB2
5indole-3-carbinol449.7BRCA2, BRCA1
6vinorelbine44 1110.7ERBB2, BRCA1
7exemestane49 44 59 1112.7ESR2, ERBB2
8toremifene44 1110.7ERBB2, ESR2
9methylmethanesulfonate449.6BRCA1, BRCA2
10fulvestrant44 49 28 1112.6ESR2, ERBB2
11letrozole44 49 59 1112.6ERBB2, ESR2
1217beta-hydroxysteroid449.6BRCA1, ESR2
13platinum44 4910.4ABCC2, BRCA1
14daidzein449.4BRCA1, BRCA2, ESR2
15sunitinib44 49 1111.3ABCC2, ERBB2
16raloxifene44 28 49 1112.3ESR2, ERBB2
17taxane449.3ABCC2, ERBB2
18thymidylate449.3BRCA1, ERBB2, ESR2
19p002449.3ERBB2, BRCA2, BRCA1
20steroid449.2ERBB2, BRCA2, BRCA1
21leucovorin44 49 1111.2ABCC2, ERBB2
22estradiol44 11 2411.2BRCA1, BRCA2, ESR2
23mitoxantrone44 49 1111.1ERBB2, ABCC2
24bortezomib44 1110.1ERBB2, BRCA1
25mitomycin c449.1ABCC2, BRCA2, BRCA1
26vincristine44 49 1111.1ABCC2, BRCA2, BRCA1
27camptothecin44 59 1111.0BRCA1, BRCA2, ABCC2
28irinotecan44 49 1111.0ERBB2, ABCC2
29topotecan44 1110.0ERBB2, ABCC2, BRCA1
30oxaliplatin44 49 1111.0ERBB2, ABCC2, BRCA1
31carboplatin44 49 1111.0ERBB2, ABCC2, BRCA1
32carbamazepine44 49 1110.9ERBB2, ABCC2
335fluorouracil448.9BRCA1, ABCC2, ERBB2
344-hydroxytamoxifen448.8BRCA1, BRCA2, ERBB2, ESR2
35resveratrol44 59 11 2411.8BRCA1, BRCA2, ERBB2, ESR2
36paraffin448.8BRCA1, BRCA2, ERBB2, ESR2
37testosterone44 59 11 2411.7ESR2, ERBB2, BRCA2, BRCA1
38retinoic acid44 249.5ESR2, ABCC2, BRCA2, BRCA1
39docetaxel44 49 59 1111.5BRCA1, BRCA2, ABCC2, ERBB2
40folate448.5ERBB2, ABCC2, BRCA2, BRCA1
41methotrexate44 49 1110.5BRCA1, BRCA2, ABCC2, ERBB2
42paclitaxel44 49 1110.5BRCA1, BRCA2, ABCC2, ERBB2
43doxorubicin44 49 1110.5BRCA1, ABCC2, ERBB2, ESR2
44cisplatin44 49 59 1111.4BRCA1, BRCA2, ABCC2, ERBB2
45etoposide44 49 59 1111.0ESR2, ERBB2, ABCC2, BRCA2, BRCA1
46tamoxifen44 49 28 1111.0BRCA1, BRCA2, ABCC2, ERBB2, ESR2
47genistein44 28 59 2 11 2413.0ESR2, ERBB2, ABCC2, BRCA2, BRCA1
48cycloheximide448.0BRCA1, BRCA2, ABCC2, ERBB2, ESR2
49progesterone44 59 28 11 2412.0ESR2, ERBB2, ABCC2, BRCA2, BRCA1
50estrogen448.0BRCA1, BRCA2, ABCC2, ERBB2, ESR2

GO Terms for genes affiliated with Fallopian Tube Cancer

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16Gene Ontology
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Biological processes related to Fallopian Tube Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-strand break repairGO:0063029.5BRCA2, BRCA1
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.4BRCA2, BRCA1
3double-strand break repair via homologous recombinationGO:0007249.2BRCA2, BRCA1

Products for genes affiliated with Fallopian Tube Cancer

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Sources for Fallopian Tube Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet