Fallopian Tube Carcinoma malady

Wikipedia: Primary fallopian tube cancer (PFTC), often just tubal cancer, is a malignant neoplasm that originates...⁴⁴ more...

MalaCards: Fallopian Tube Carcinoma, also known as fallopian tube cancer, is related to squamous cell carcinoma and prostate carcinoma. An important gene associated with Fallopian Tube Carcinoma is BRCA2 (breast cancer 2, early onset), and among its related pathways are Pancreatic cancer and DNA damage_DNA-damage-induced responses. The drugs carmustine and diethylstilbestrol diphosphate and the compounds mitomycin c and anastrozole have been mentioned in the context of this disorder. Affiliated tissues include the fallopian tube, and related mouse phenotypes are behavior/neurological and mortality/aging.

Disease Ontology: A fallopian tube cancer that is located in the fallopian tube.⁶

Aliases & Descriptions:

fallopian tube carcinoma 6 8 32 43 fallopian tube cancer 30 8 32 cancer of the fallopian tube 6 30 carcinoma of fallopian tube (disorder) 6

renal tubular disorder 43 malignant neoplasms 43 fallopian tube ca 6 carcinoma 43

Diseases related to fallopian tube carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1522)

id	Related Disease	Score	Top Affiliating Genes
1	squamous cell carcinoma	38.6	MYC, MUC16, CDKN1B, MKI67, ERBB2, TP53
2	prostate carcinoma	37.3	BRCA2, ERBB2, TP53
3	hepatocellular carcinoma	36.4	BRCA2, MYC, CDKN1B, MKI67, ESR1, ERBB2
4	renal cell carcinoma	35.9	MYC, MUC16, CDKN1B, MKI67, ESR1, ERBB2
5	lung carcinoma	35.8	MYC, MUC16, CDKN1B, MKI67, ERBB2, TP53
6	oral squamous cell carcinoma	35.7	MYC, CDKN1B, MKI67, ERBB2, TP53
7	papillary thyroid carcinoma	35.0	CDKN1B, MKI67, ERBB2, TP53
8	thyroid carcinoma	34.9	MYC, CDKN1B, MKI67, ESR1, ERBB2, TP53
9	thyroiditis	34.7	MYC, MUC16, CDKN1B, MKI67, ESR1, ERBB2
10	non-small cell lung carcinoma	34.6	MYC, ERBB2, TP53
11	breast carcinoma	34.1	BRCA1, BRCA2, MYC, BCAS4, MUC16, CDKN1B
12	bladder carcinoma	34.0	MYC, CDKN1B, MKI67, ERBB2, TP53
13	renal carcinoma	34.0	MYC, CDKN1B, MKI67, TP53
14	laryngeal squamous cell carcinoma	33.9	MYC, MKI67, ERBB2, TP53
15	colon carcinoma	33.7	BRCA1, MYC, CDKN1B, MKI67, ESR1, ERBB2
16	pancreatic carcinoma	33.4	BRCA2, CDKN1B, MKI67, ESR1, ERBB2, TP53
17	ovarian carcinoma	33.4	BRCA1, BRCA2, MYC, MUC16, CDKN1B, MKI67
18	squamous cell carcinoma of the head and neck	33.4	MYC, MUC16, CDKN1B, MKI67, ERBB2, TP53
19	esophageal carcinoma	33.4	MYC, CDKN1B, MKI67, ERBB2, TP53
20	nasopharyngitis	33.4	MYC, CDKN1B, MKI67, ESR1, ERBB2, TP53
21	small cell carcinoma	33.3	BRCA1, BRCA2, CDKN1B, MKI67, ERBB2, TP53
22	esophageal squamous cell carcinoma	33.1	BRCA2, MYC, CDKN1B, MKI67, ESR1, ERBB2
23	prostatitis	33.0	BRCA1, BRCA2, MYC, MUC16, CDKN1B, MKI67
24	esophagitis	33.0	BRCA1, BRCA2, MYC, MUC16, CDKN1B, MKI67
25	mucoepidermoid carcinoma	32.9	CDKN1B, MKI67, TP53
26	cervical carcinoma	32.8	MYC, CDKN1B, MKI67, ESR1, ERBB2, TP53
27	endometrial carcinoma	32.3	BRCA1, BRCA2, MYC, MUC16, CDKN1B, MKI67
28	cervicitis	32.2	BRCA1, BRCA2, MYC, MUC16, CDKN1B, MKI67
29	gallbladder carcinoma	32.1	MYC, CDKN1B, MKI67, ERBB2, TP53
30	laryngeal carcinoma	31.9	MYC, CDKN1B, MKI67, ESR1, ERBB2, TP53
31	multiple endocrine neoplasia	31.8	BRCA1, BRCA2, CDKN1B
32	parathyroid carcinoma	31.7	BRCA2, MKI67, TP53
33	colorectal adenoma and carcinoma	31.7	MKI67, ERBB2, TP53
34	cervical squamous cell carcinoma	31.6	MYC, CDKN1B, MKI67, TP53
35	laryngitis	31.6	BRCA1, BRCA2, MYC, MUC16, CDKN1B, MKI67
36	adenosquamous carcinoma	31.5	MKI67, TP53, PGR
37	pancreatitis	31.5	BRCA1, BRCA2, MYC, MUC16, CDKN1B, MKI67
38	bile duct carcinoma	31.3	MYC, ERBB2, TP53
39	adenoid cystic carcinoma	31.2	MUC16, CDKN1B, MKI67, ESR1, ERBB2, TP53
40	adenoiditis	31.2	MUC16, CDKN1B, MKI67, ESR1, ERBB2, TP53
41	adenoma	30.9	BRCA1, MYC, MUC16, CDKN1B, MKI67, ESR1
42	neuroendocrine carcinoma	30.7	MUC16, CDKN1B, MKI67, ESR1, ERBB2, TP53
43	ovarian cancer	30.6	BRCA1, BRCA2, CDKN1B
44	ductal carcinoma in situ	30.5	BRCA1, BRCA2, MUC16, CDKN1B, MKI67, ESR1
45	hypoxia	30.4	BRCA1, MYC, CDKN1B, MKI67, ESR1, ERBB2
46	peritonitis	30.2	BRCA1, BRCA2, MUC16, ESR1, ERBB2, TP53
47	adenocarcinoma	30.2	BRCA1, BRCA2, MYC, MUC16, CDKN1B, MKI67
48	basaloid squamous cell carcinoma	30.2	MYC, CDKN1B, MKI67, TP53
49	papillary serous carcinoma of the peritoneum	29.8	BRCA1, MUC16
50	cholangiocarcinoma	29.7	MYC, CDKN1B, MKI67, ERBB2, TP53

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, nilutamide

FMA organs/tissues related to fallopian tube carcinoma:

¹¹

MGI Mouse Phenotypes related to fallopian tube carcinoma:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological phenotype	MP:0005386	9.6	BRCA2, CDKN1B, PGR
2	mortality/aging	MP:0010768	8.8	TEAD4, TP53, CDKN1B, BRCA2, BRCA1
3	limbs/digits/tail phenotype	MP:0005371	8.8	ERBB2, ESR1, BRCA2, BRCA1
4	pigmentation phenotype	MP:0001186	8.8	TP53, CDKN1B, MYC, BRCA1
5	adipose tissue phenotype	MP:0005375	8.1	TP53, ESR1, CDKN1B, MYC, BRCA1
6	normal phenotype	MP:0002873	7.7	PGR, TEAD4, TP53, ERBB2, MYC, BRCA2
7	digestive/alimentary phenotype	MP:0005381	7.3	TP53, ERBB2, ESR1, CDKN1B, MYC, BRCA2
8	skeleton phenotype	MP:0005390	7.2	PGR, TP53, ERBB2, ESR1, MYC, BRCA2
9	hematopoietic system phenotype	MP:0005397	7.1	PGR, TP53, ESR1, CDKN1B, MYC, BRCA2
10	muscle phenotype	MP:0005369	7.1	PGR, TP53, ERBB2, ESR1, CDKN1B, MYC
11	embryogenesis phenotype	MP:0005380	7.0	PGR, TEAD4, TP53, ERBB2, ESR1, MYC
12	tumorigenesis	MP:0002006	6.9	BRCA1, PGR, TP53, ERBB2, ESR1, CDKN1B
13	cardiovascular system phenotype	MP:0005385	6.9	PGR, TP53, ERBB2, ESR1, CDKN1B, MYC
14	integument phenotype	MP:0010771	6.9	PGR, TP53, ERBB2, ESR1, CDKN1B, MYC
15	endocrine/exocrine gland phenotype	MP:0005379	6.9	PGR, TP53, ERBB2, ESR1, CDKN1B, MYC
16	reproductive system phenotype	MP:0005389	6.9	PGR, TP53, ERBB2, ESR1, CDKN1B, MYC
17	homeostasis/metabolism phenotype	MP:0005376	6.6	TP53, ERBB2, ESR1, CDKN1B, MYC, BRCA2
18	cellular phenotype	MP:0005384	6.3	PGR, TP53, ERBB2, ESR1, CDKN1B, MYC

Articles related to fallopian tube carcinoma:

id	Title	Authors	Year	Affiliating Genes
1	Microinvasive fimbrial fallopian tube carcinoma in a BRCA-2 mutation carrier. (18207147)	Paccagnella G.L.... Ruggio F.	2008	BRCA2
2	Expression of insulin-like growth factor-1 receptors, Wilm's tumor-1 protein, c-kit and p16 in primary fallopian tube carcinoma in diabetic patients. (17972088)	Al-Salam S.... Ghazal-Aswad S.	2008	MUC16
3	HER-2/neu and p27Kip1 in progression of Fallopian tube carcinoma: an immunohistochemical and array comparative genomic hybridization study. (17927588)	Nowee M.E.... van Diest P.J.	2007	ERBB2, CDKN1B
4	BRCA-mutation-associated fallopian tube carcinoma: a distinct clinical phenotype? (16319259)	Cass I.... Karlan B.Y.	2005	TP53, PGR, ESR1
5	Follow-up of in situ and early-stage fallopian tube carcinoma in patients undergoing prophylactic surgery for proven or suspected BRCA-1 or BRCA-2 mutations. (15252324)	Agoff S.N.... Swisher E.	2004	BRCA1, BRCA2
6	Incidental diagnosis of primary fallopian tube carcinoma during prophylactic salpingo-oophorectomy in BRCA2 mutation carrier. (12504983)	Peyton-Jones B.... Murdoch J.B.	2002	BRCA2
7	Recurrent fallopian tube carcinoma: TP53 mutation and clinical course. (10782411)	HellstrAPm A.C.... Auer G.	2000	TP53
8	Overexpression of p53 and HER-2/neu and c-myc in primary fallopian tube carcinoma. (10629373)	Chung T.K.... Wong Y.F.	2000	MYC
9	Germline BRCA2 mutation in a patient with fallopian tube carcinoma: a case report. (10785486)	Rose P.G.... Wiesner G.L.	2000	BRCA2

Genes related to fallopian tube carcinoma according to GeneCards:

(show all 13)

id	Symbol	Description	Score	GeneCards Section Context
1	BRCA2	breast cancer 2, early onset	11.0	Publications
2	BRCA1	breast cancer 1, early onset	11.0	Publications
3	BCAS4	breast carcinoma amplified sequence 4	11.0
4	TEAD4	TEA domain family member 4	11.0
5	MUC16	mucin 16, cell surface associated	11.0	Publications
6	TSPAN9	tetraspanin 9	11.0
7	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
8	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	11.0	Publications
9	PGR	progesterone receptor	11.0	Publications
10	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	11.0	Publications
11	ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	11.0	Publications
12	ESR1	estrogen receptor 1	11.0	Publications
13	TP53	tumor protein p53	11.0	Publications

Pathways related to fallopian tube carcinoma according to GeneDecks:

(show all 31)

id	Pathway	Score	Top Affiliating Genes
1	Pancreatic cancer20	10.5	BRCA2
2	DNA damage_DNA-damage-induced responses41	10.5	BRCA1
3	DNA damage DNA-damage-induced responses10	10.5	BRCA1
4	DNA damage ATM/ATR regulation of G1/S checkpoint10	10.3	MYC
5	ErbB2-ErbB3 Heterodimers36	10.2	ERBB2
6	Fanconis Anaemia Pathway36	9.9	BRCA2, BRCA1
7	DNA damage_Role of Brca1 and Brca2 in DNA repair41	9.8	TP53, BRCA2, BRCA1
8	DNA damage Role of Brca1 and Brca2 in DNA repair10	9.8	TP53, BRCA2, BRCA1
9	BRCA1 Pathway36	9.8	BRCA1, BRCA2, TP53
10	DNA Damage3	9.7	BRCA1, BRCA2, TP53
11	Glioblastoma Multiforme36	9.7	TP53, CDKN1B
12	DNA damage_ATM/ATR regulation of G1/S checkpoint41	9.5	TP53, MYC, BRCA1
13	DNA Repair Mechanisms36	9.5	TP53, BRCA2, BRCA1
14	Inhibition of Ribosome Biogenesis by p14(ARF)36	9.4	MYC, TP53
15	DNA Damage Induced 14-3-3Sigma Signaling36	9.4	TP53, BRCA1
16	Cell Cycle / Checkpoint Control3	9.4	BRCA1, BRCA2, CDKN1B, TP53
17	Signal transduction_AKT signaling41	9.4	MYC, CDKN1B, TP53
18	Chronic myeloid leukemia20	9.3	TP53, CDKN1B, MYC
19	Nuclear signaling by ERBB438	9.3	ESR1, PGR
20	Small cell lung cancer20	9.3	MYC, CDKN1B, TP53
21	Bladder cancer20	9.2	MYC, ERBB2, TP53
22	Endometrial cancer20	9.2	TP53, ERBB2, MYC
23	ErbB signaling pathway20	9.1	ERBB2, CDKN1B, MYC
24	Prostate cancer20	9.1	CDKN1B, ERBB2, TP53
25	Cell cycle ESR1 regulation of G1/S transition10	9.1	ESR1, CDKN1B, MYC
26	Cell cycle_ESR1 regulation of G1/S transition41	9.1	MYC, CDKN1B, ESR1
27	Estrogen-mediated S-Phase Entry36	9.1	MYC, CDKN1B, ESR1
28	Cell cycle20	9.0	MYC, CDKN1B, TP53
29	Pancreatic Adenocarcinoma36	8.9	TP53, ERBB2, CDKN1B, BRCA2
30	Molecular Mechanisms of Cancer36	8.9	BRCA1, MYC, CDKN1B, TP53
31	Pathways in cancer20	8.5	BRCA2, MYC, CDKN1B, ERBB2, TP53

Compounds related to fallopian tube carcinoma according to GeneDecks:

(show top 50)    (show all 111)

id	Compound	Score	Top Affiliating Genes
1	mitomycin c32	10.0	BRCA2, BRCA1
2	anastrozole32 42 9 9	12.4	ESR1, ERBB2
3	4-hydroxytamoxifen32	9.2	BRCA1, BRCA2, MYC, ERBB2
4	daidzein32	9.1	ESR1, BRCA2, BRCA1
5	aphidicolin32	9.1	TP53, CDKN1B, BRCA1, MYC
6	topotecan32 9 9	11.1	ERBB2, TP53, BRCA1, MUC16
7	hydroxyurea32 9 9	11.0	TP53, BRCA1, BRCA2, MYC
8	carboplatin32 34 9 9	12.0	BRCA1, MUC16, ERBB2, TP53
9	droloxifene32	9.0	MYC, ESR1, PGR
10	17beta-hydroxysteroid32	8.9	BRCA1, ESR1, MKI67, PGR
11	camptothecin32 42 9 9	11.9	TP53, CDKN1B, MYC, BRCA2, BRCA1
12	exemestane32 34 9 9	11.8	PGR, ESR1, ERBB2
13	etoposide32 42 9 9	11.8	TP53, MYC, CDKN1B, ERBB2
14	megestrol acetate32	8.8	ERBB2, PGR, ESR1
15	lapatinib32 34 9 9	11.7	PGR, ERBB2, ESR1
16	lactacystin32	8.7	BRCA1, TP53, CDKN1B, MYC
17	indole-3-carbinol32	8.6	ESR1, CDKN1B, TP53, BRCA1, BRCA2
18	letrozole32 42 9 9	11.6	ERBB2, PGR, ESR1, MKI67
19	bortezomib32 9 9	10.5	CDKN1B, ERBB2, BRCA1, MYC, TP53
20	gemcitabine32 34 9 9	11.5	BRCA1, MYC, TP53, ERBB2, CDKN1B
21	retinoic acid32 42 18	10.5	BRCA2, BRCA1, PGR, ESR1, MYC
22	raloxifene32 9 9	10.5	CDKN1B, PGR, ERBB2, ESR1
23	trastuzumab32 34 9 9	11.4	ERBB2, PGR, CDKN1B, ESR1
24	taxane32	8.4	TP53, PGR, ERBB2, ESR1
25	agar32	8.4	BRCA1, PGR, MYC, ERBB2, CDKN1B
26	folate32	8.4	PGR, ERBB2, MKI67, BRCA2, BRCA1, MYC
27	thymidine32 18	9.4	TP53, BRCA1, BRCA2, MYC, MKI67, CDKN1B
28	n-(4-hydroxyphenyl)retinamide32	8.3	ERBB2, MYC, ESR1, TP53
29	toremifene32 9 9	10.3	PGR, ESR1, ERBB2
30	mg 13232 42	9.3	BRCA1, CDKN1B, MYC, TP53, ESR1
31	adriamycin32	8.2	BRCA2, PGR, TP53, ERBB2, MYC, BRCA1
32	5-aza-2deoxycytidine32	8.2	TP53, ESR1, MYC, BRCA1, PGR
33	geldanamycin32 9 9	10.2	ERBB2, TP53, ESR1, PGR
34	estradiol32 9 18 9	11.0	MKI67, PGR, ESR1, CDKN1B, MUC16, BRCA2
35	methotrexate32 34 42 9 9	11.7	BRCA2, CDKN1B, MKI67, ESR1, ERBB2, BRCA1
36	steroid32	7.7	BRCA1, BRCA2, MUC16, MKI67, ESR1, PGR
37	cisplatin32 34 9 9	10.6	TP53, BRCA2, MYC, MUC16, CDKN1B, MKI67
38	resveratrol32 9 18 9	10.6	TP53, PGR, BRCA1, BRCA2, CDKN1B, ESR1
39	genistein32 9 18 9	10.5	BRCA1, BRCA2, MYC, CDKN1B, ESR1, PGR
40	docetaxel32 34 9 9	10.5	ESR1, BRCA1, PGR, TP53, ERBB2, MYC
41	5fluorouracil32	7.4	CDKN1B, MKI67, ESR1, ERBB2, TP53, PGR
42	testosterone32 9 18 9	10.4	ESR1, MKI67, MUC16, BRCA2, BRCA1, CDKN1B
43	progesterone32 42 9 18 9	10.9	MUC16, PGR, TP53, ERBB2, ESR1, MKI67
44	tamoxifen32 34 9 9	9.7	ESR1, BRCA1, BRCA2, MYC, PGR, TP53
45	cycloheximide32	6.7	PGR, TP53, ERBB2, MYC, BRCA2, CDKN1B
46	doxorubicin32 34 9 9	9.6	PGR, BRCA1, MYC, MUC16, CDKN1B, MKI67
47	vegf32	6.6	PGR, BRCA1, MYC, MUC16, CDKN1B, MKI67
48	paclitaxel32 34 9 9	9.4	PGR, BRCA1, BRCA2, MYC, MUC16, CDKN1B
49	paraffin32	6.4	TP53, BRCA1, BRCA2, MYC, MUC16, PGR
50	estrogen32	6.3	MYC, TP53, BRCA2, ERBB2, ESR1, MKI67

Cellular components related to fallopian tube carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein complex	GO:043234	8.9	BRCA1, BRCA2, MYC, TP53
2	nucleoplasm	GO:005654	6.6	BRCA1, PGR, TEAD4, TP53, ESR1, CDKN1B

Biological processes related to fallopian tube carcinoma according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell cycle arrest	GO:071158	9.8	BRCA1, TP53
2	mitotic cell cycle arrest	GO:071850	9.7	TP53, CDKN1B
3	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:006978	9.7	BRCA1, BRCA2, TP53
4	double-strand break repair	GO:006302	9.6	BRCA1, BRCA2, TP53
5	response to gamma radiation	GO:010332	9.4	BRCA2, MYC, TP53
6	chromosome organization	GO:051276	9.3	TP53, MYC
7	mammary gland development	GO:030879	9.3	ERBB2, BRCA2
8	response to DNA damage stimulus	GO:006974	9.2	BRCA1, MYC, TP53
9	cell cycle arrest	GO:007050	9.0	MYC, CDKN1B, TP53
10	transcription initiation from RNA polymerase II promoter	GO:006367	8.6	PGR, TEAD4, ESR1, MYC

Molecular functions related to fallopian tube carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:019899	8.4	BRCA1, ESR1, TP53, PGR
2	protein binding	GO:005515	5.3	BRCA1, PGR, TEAD4, TP53, ERBB2, ESR1