MCID: FML155
MIFTS: 17

Familial Acute Myeloid Leukemia with Mutated Cebpa malady

Categories: Genetic diseases (common), Cancer diseases

Aliases & Classifications for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Aliases & Descriptions for Familial Acute Myeloid Leukemia with Mutated Cebpa:

Name: Familial Acute Myeloid Leukemia with Mutated Cebpa 22
Familial Acute Myeloid Leukemia with Mutated Cebpa 23 65
 
Cebpa-Dependent Familial Acute Myeloid Leukemia 22 23
Familial Acute Myeloid Leukaemia 23

Classifications:



External Ids:

UMLS65 C3711382

Summaries for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Genetics Home Reference:23 Familial acute myeloid leukemia with mutated CEBPA is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body from infection, red blood cells (erythrocytes) that carry oxygen, and platelets (thrombocytes) that are involved in blood clotting. In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. The large number of abnormal cells in the bone marrow interferes with the production of functional white blood cells, red blood cells, and platelets.

MalaCards based summary: Familial Acute Myeloid Leukemia with Mutated Cebpa, also known as familial acute myeloid leukemia with mutated cebpa, is related to cebpa-associated familial acute myeloid leukemia and pelger-huet anomaly. An important gene associated with Familial Acute Myeloid Leukemia with Mutated Cebpa is CEBPA (CCAAT/Enhancer Binding Protein Alpha). Affiliated tissues include myeloid, bone and bone marrow.

Related Diseases for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Diseases related to Familial Acute Myeloid Leukemia with Mutated Cebpa via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1cebpa-associated familial acute myeloid leukemia11.5
2pelger-huet anomaly9.8

Symptoms for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Drugs & Therapeutics for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Drugs for Familial Acute Myeloid Leukemia with Mutated Cebpa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
ponatinibapprovedPhase 1, Phase 229943319-70-824826799
Synonyms:
AP 24534
AP24534
 
Iclusig
Ponatinib Hydrochloride
Ponatinibum
ponatinib
2
Cytarabineapproved, investigationalPhase 1, Phase 21035147-94-46253
Synonyms:
(beta-D-Arabinofuranosyl)cytosine
(beta-D-arabinofuranosyl)cytosine
1-.beta.-D-arabinofuranosyl-cytosine
1-Arabinofuranosylcytosine
1-beta -D-Arabinofaranosylcytosine
1-beta -D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone
1-beta -D-Arabinofuranosylcytosine
1-beta-D-Arabinofaranosylcytosine
1-beta-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone
1-beta-D-Arabinofuranosyl-Cytosine
1-beta-D-Arabinofuranosylcytosine
1-beta-D-Arabinofuranosylcytosine, Cytosine Arabinoside
1-beta-D-Arabinosyl-Cytosine
1-beta-D-Arabinosylcytosine
147-94-4
1beta -Arabinofuranasylcytosine
1beta -D-Arabinofuranosylcytosine
1beta -D-Arabinosylcytosine
1beta-Arabinofuranasylcytosine
1beta-D-Arabinofuranosylcytosine
1beta-D-Arabinosylcytosine
2(1H)-Pyrimidinone, 4-amino-1- -D-arabinofuranosyl- [CAS]
2(1H)-Pyrimidinone, 4-amino-1- -D-arabinofuranosyl
30399_FLUKA
4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin
4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin [Czech]
4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine
4-Amino-1-b-D-arabinofuranosyl-2-(1H)-pyrimidinone
4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon
4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon [Czech]
4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone
4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one
69-74-9 (hydrochloride)
AC-1075
AC1L1M4F
AC1Q52OJ
AI3-52329
AR3
Alexan
Ara-C
Ara-C, Cytosine Arabinoside, Cytosar-U, Cytarabine
Ara-Cytidine
AraC
Arabinocytidine
Arabinofuranosyl Cytidine
Arabinofuranosylcytosine
Arabinosyl Cytosine
Arabinosylcytosine
Arabitin
Aracytidine
Aracytin
Aracytine
Arafcyt
BIDD:GT0371
BIDD:PXR0139
BTB15125
Beta-cytosine arabinoside
C02961
C1768_SIGMA
C2035
C9H13N3O5
CCRIS 913
CHEBI:28680
CHEMBL803
CHX 3311
CID6253
CPD000449317
CYTARABINE (SEE ALSO CYTARABINE HYDROCHLORIDE 69-74-9)
Citarabina
Citarabina [INN-Spanish]
Cytarabin
Cytarabina
Cytarabine
Cytarabine (JP15/USP/INN)
 
Cytarabine [USAN:INN:BAN:JAN]
Cytarabine liposome injection
Cytarabinoside
Cytarabinum
Cytarabinum [INN-Latin]
Cytarbel
Cytonal
Cytosar
Cytosar-U
Cytosine 1-beta-D-arabinofuranoside
Cytosine arabinofuranoside
Cytosine arabinose
Cytosine arabinoside
Cytosine arabinoside (VAN)
Cytosine beta-D-arabinofuranoside
Cytosine beta-D-arabinofuranoside hydrochloride
Cytosine beta-D-arabinoside
Cytosine, beta -D-arabinoside
Cytosine, beta-D-arabinoside
Cytosine-1-beta-D-arabinofuranoside
Cytosine-1-beta-D-arabinofuranoside hydrochloride
Cytosine-beta -D-arabinofuranoside
Cytosine-beta -arabinoside
Cytosine-beta-D-arabinofuranoside
Cytosine-beta-arabinoside
Cytosinearabinoside
D00168
DB00987
DepoCyte
Depocyt
Depocyt (TN)
Depocyt (liposomal)
Depocyte
EINECS 205-705-9
Erpalfa
FT-0082880
HMS2051K19
HMS2090A18
HSDB 3049
Intrathecal (injected into the spinal fluid) DepoCyt
Intrathecal cytarabine (also known as ara-C)
Iretin
LS-860
Lopac0_000316
MLS000758310
MLS001066340
MolPort-001-792-509
NCGC00093356-03
NCGC00093356-04
NCGC00093356-05
NCI-C04728
NSC 287459
NSC287459
S1648_Selleck
SAM001247012
SMR000449317
SR-01000075773-3
Spongocytidine
TL8001048
Tarabine
U 19920A
U-19,920
U-19920
UNII-04079A1RDZ
Udicil
ZINC03795098
beta -D-arabinosylcytosine
beta -arabinosylcytosine
beta -cytosine arabinoside
beta-Ara C
beta-Ara c
beta-Arabinosylcytosine
beta-Cytosine arabinoside
beta-D-Arabinosylcytosine
cytarabine
cytarabine liposome injection
cytosine-β-D-arabinofuranoside
3AntimetabolitesPhase 1, Phase 29454
4PONATINIB Phase 1, Phase 2
5Protein Kinase InhibitorsPhase 1, Phase 23162
6Immunosuppressive AgentsPhase 1, Phase 210422
7Immunologic FactorsPhase 1, Phase 218483
8Antiviral AgentsPhase 1, Phase 28071
9Anti-Infective AgentsPhase 1, Phase 217220
10Antimetabolites, AntineoplasticPhase 1, Phase 25770

Interventional clinical trials:

idNameStatusNCT IDPhase
1Ponatinib AML: Therapy for Patients With Intermediate-Risk Cytogenetic FLT3-ITD AML in First CRRecruitingNCT02428543Phase 1, Phase 2

Search NIH Clinical Center for Familial Acute Myeloid Leukemia with Mutated Cebpa

Genetic Tests for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Genetic tests related to Familial Acute Myeloid Leukemia with Mutated Cebpa:

id Genetic test Affiliating Genes
1 Familial Acute Myeloid Leukemia (aml) with Mutated Cebpa22 CEBPA

Anatomical Context for Familial Acute Myeloid Leukemia with Mutated Cebpa

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MalaCards organs/tissues related to Familial Acute Myeloid Leukemia with Mutated Cebpa:

33
Myeloid, Bone, Bone marrow, Endothelial

Animal Models for Familial Acute Myeloid Leukemia with Mutated Cebpa or affiliated genes

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Publications for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Variations for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Expression for genes affiliated with Familial Acute Myeloid Leukemia with Mutated Cebpa

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Search GEO for disease gene expression data for Familial Acute Myeloid Leukemia with Mutated Cebpa.

Pathways for genes affiliated with Familial Acute Myeloid Leukemia with Mutated Cebpa

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GO Terms for genes affiliated with Familial Acute Myeloid Leukemia with Mutated Cebpa

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Sources for Familial Acute Myeloid Leukemia with Mutated Cebpa

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet