MCID: FML155
MIFTS: 14

Familial Acute Myeloid Leukemia with Mutated Cebpa malady

Categories: Genetic diseases (common), Cancer diseases

Aliases & Classifications for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Aliases & Descriptions for Familial Acute Myeloid Leukemia with Mutated Cebpa:

Name: Familial Acute Myeloid Leukemia with Mutated Cebpa 24
Familial Acute Myeloid Leukemia with Mutated Cebpa 25 68
 
Cebpa-Dependent Familial Acute Myeloid Leukemia 24 25
Familial Acute Myeloid Leukaemia 25

Classifications:



Summaries for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Genetics Home Reference:25 Familial acute myeloid leukemia with mutated CEBPA is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body from infection; red blood cells (erythrocytes) that carry oxygen; and platelets (thrombocytes), which are cell fragments that are involved in blood clotting. In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. The large number of abnormal cells in the bone marrow interferes with the production of functional white blood cells, red blood cells, and platelets.

MalaCards based summary: Familial Acute Myeloid Leukemia with Mutated Cebpa, also known as familial acute myeloid leukemia with mutated cebpa, is related to cebpa-associated familial acute myeloid leukemia and pelger-huet anomaly. An important gene associated with Familial Acute Myeloid Leukemia with Mutated Cebpa is CEBPA (CCAAT/Enhancer Binding Protein Alpha). Affiliated tissues include myeloid, bone and bone marrow.

Related Diseases for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Diseases related to Familial Acute Myeloid Leukemia with Mutated Cebpa via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1cebpa-associated familial acute myeloid leukemia11.3
2pelger-huet anomaly9.7

Symptoms & Phenotypes for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Drugs & Therapeutics for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Drugs for Familial Acute Myeloid Leukemia with Mutated Cebpa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
ponatinibapprovedPhase 1, Phase 232943319-70-824826799
Synonyms:
AP 24534
AP24534
 
Iclusig
Ponatinibum
ponatinib
2
Cytarabineapproved, investigationalPhase 1, Phase 21117147-94-46253
Synonyms:
(beta-D-Arabinofuranosyl)cytosine
(beta-D-arabinofuranosyl)cytosine
1-.beta.-D-arabinofuranosyl-cytosine
1-Arabinofuranosylcytosine
1-beta -D-Arabinofaranosylcytosine
1-beta -D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone
1-beta -D-Arabinofuranosylcytosine
1-beta-D-Arabinofaranosylcytosine
1-beta-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone
1-beta-D-Arabinofuranosyl-Cytosine
1-beta-D-Arabinofuranosylcytosine
1-beta-D-Arabinofuranosylcytosine, Cytosine Arabinoside
1-beta-D-Arabinosyl-Cytosine
1-beta-D-Arabinosylcytosine
147-94-4
1beta -Arabinofuranasylcytosine
1beta -D-Arabinofuranosylcytosine
1beta -D-Arabinosylcytosine
1beta-Arabinofuranasylcytosine
1beta-D-Arabinofuranosylcytosine
1beta-D-Arabinosylcytosine
2(1H)-Pyrimidinone, 4-amino-1- -D-arabinofuranosyl- [CAS]
2(1H)-Pyrimidinone, 4-amino-1- -D-arabinofuranosyl
30399_FLUKA
4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin
4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin [Czech]
4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine
4-Amino-1-b-D-arabinofuranosyl-2-(1H)-pyrimidinone
4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon
4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon [Czech]
4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone
4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one
69-74-9 (hydrochloride)
AC-1075
AC1L1M4F
AC1Q52OJ
AI3-52329
AR3
Alexan
Ara-C
Ara-C, Cytosine Arabinoside, Cytosar-U, Cytarabine
Ara-Cytidine
AraC
Arabinocytidine
Arabinofuranosylcytosine
Arabinosyl Cytosine
Arabinosylcytosine
Arabitin
Aracytidine
Aracytin
Aracytine
Arafcyt
BIDD:GT0371
BIDD:PXR0139
BTB15125
Beta-cytosine arabinoside
C02961
C1768_SIGMA
C2035
C9H13N3O5
CCRIS 913
CHEBI:28680
CHEMBL803
CHX 3311
CID6253
CPD000449317
CYTARABINE (SEE ALSO CYTARABINE HYDROCHLORIDE 69-74-9)
Citarabina
Citarabina [INN-Spanish]
Cytarabin
Cytarabina
Cytarabine (JP15/USP/INN)
Cytarabine [USAN:INN:BAN:JAN]
 
Cytarabine liposome injection
Cytarabinoside
Cytarabinum
Cytarabinum [INN-Latin]
Cytarbel
Cytonal
Cytosar
Cytosar-U
Cytosine 1-beta-D-arabinofuranoside
Cytosine arabinofuranoside
Cytosine arabinose
Cytosine arabinoside
Cytosine arabinoside (VAN)
Cytosine beta-D-arabinofuranoside
Cytosine beta-D-arabinofuranoside hydrochloride
Cytosine beta-D-arabinoside
Cytosine, beta -D-arabinoside
Cytosine, beta-D-arabinoside
Cytosine-1-beta-D-arabinofuranoside
Cytosine-1-beta-D-arabinofuranoside hydrochloride
Cytosine-beta -D-arabinofuranoside
Cytosine-beta -arabinoside
Cytosine-beta-D-arabinofuranoside
Cytosine-beta-arabinoside
Cytosinearabinoside
D00168
DB00987
DepoCyte
Depocyt
Depocyt (TN)
Depocyt (liposomal)
Depocyte
EINECS 205-705-9
Erpalfa
FT-0082880
HMS2051K19
HMS2090A18
HSDB 3049
Intrathecal (injected into the spinal fluid) DepoCyt
Intrathecal cytarabine (also known as ara-C)
Iretin
LS-860
Lopac0_000316
MLS000758310
MLS001066340
MolPort-001-792-509
NCGC00093356-03
NCGC00093356-04
NCGC00093356-05
NCI-C04728
NSC 287459
NSC287459
S1648_Selleck
SAM001247012
SMR000449317
SR-01000075773-3
Spongocytidine
TL8001048
Tarabine
U 19920A
U-19,920
U-19920
UNII-04079A1RDZ
Udicil
ZINC03795098
beta -D-arabinosylcytosine
beta -arabinosylcytosine
beta -cytosine arabinoside
beta-Ara C
beta-Ara c
beta-Arabinosylcytosine
beta-Cytosine arabinoside
beta-D-Arabinosylcytosine
cytarabine
cytarabine liposome injection
cytosine-β-D-arabinofuranoside
3PONATINIB Phase 1, Phase 2
4Protein Kinase InhibitorsPhase 1, Phase 23689
5AntimetabolitesPhase 1, Phase 212054
6Immunosuppressive AgentsPhase 1, Phase 213086
7Antiviral AgentsPhase 1, Phase 29967
8Anti-Infective AgentsPhase 1, Phase 222062
9Antimetabolites, AntineoplasticPhase 1, Phase 27361

Interventional clinical trials:

idNameStatusNCT IDPhase
1Ponatinib for FLT3-ITD Acute Myelogenous LeukemiaRecruitingNCT02428543Phase 1, Phase 2
2Next Generation Sequencing (NGS) in Familial Acute Myeloid Leukemia and Myelodisplastic SyndromesRecruitingNCT03058588
3Familial Investigations of Childhood Cancer PredispositionRecruitingNCT03050268
4Studying Tissue and Blood Samples From Patients With Acute Myeloid LeukemiaActive, not recruitingNCT00900224

Search NIH Clinical Center for Familial Acute Myeloid Leukemia with Mutated Cebpa

Genetic Tests for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Genetic tests related to Familial Acute Myeloid Leukemia with Mutated Cebpa:

id Genetic test Affiliating Genes
1 Familial Acute Myeloid Leukemia (aml) with Mutated Cebpa24 CEBPA

Anatomical Context for Familial Acute Myeloid Leukemia with Mutated Cebpa

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MalaCards organs/tissues related to Familial Acute Myeloid Leukemia with Mutated Cebpa:

36
Myeloid, Bone, Bone marrow

Publications for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Variations for Familial Acute Myeloid Leukemia with Mutated Cebpa

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Expression for genes affiliated with Familial Acute Myeloid Leukemia with Mutated Cebpa

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Search GEO for disease gene expression data for Familial Acute Myeloid Leukemia with Mutated Cebpa.

Pathways for genes affiliated with Familial Acute Myeloid Leukemia with Mutated Cebpa

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GO Terms for genes affiliated with Familial Acute Myeloid Leukemia with Mutated Cebpa

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Sources for Familial Acute Myeloid Leukemia with Mutated Cebpa

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet