MCID: FML155
MIFTS: 14

Familial Acute Myeloid Leukemia with Mutated Cebpa malady

Categories: Genetic diseases, Cancer diseases

Aliases & Classifications for Familial Acute Myeloid Leukemia with Mutated Cebpa

Aliases & Descriptions for Familial Acute Myeloid Leukemia with Mutated Cebpa:

Name: Familial Acute Myeloid Leukemia with Mutated Cebpa 24
Familial Acute Myeloid Leukemia with Mutated Cebpa 25 69
Cebpa-Dependent Familial Acute Myeloid Leukemia 24 25
Familial Acute Myeloid Leukaemia 25

Classifications:



Summaries for Familial Acute Myeloid Leukemia with Mutated Cebpa

Genetics Home Reference : 25 Familial acute myeloid leukemia with mutated CEBPA is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body from infection; red blood cells (erythrocytes) that carry oxygen; and platelets (thrombocytes), which are cell fragments that are involved in blood clotting. In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. The large number of abnormal cells in the bone marrow interferes with the production of functional white blood cells, red blood cells, and platelets.

MalaCards based summary : Familial Acute Myeloid Leukemia with Mutated Cebpa, also known as familial acute myeloid leukemia with mutated cebpa, is related to cebpa-associated familial acute myeloid leukemia and pelger-huet anomaly. An important gene associated with Familial Acute Myeloid Leukemia with Mutated Cebpa is CEBPA (CCAAT/Enhancer Binding Protein Alpha). The drugs Cytarabine and ponatinib have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow.

Related Diseases for Familial Acute Myeloid Leukemia with Mutated Cebpa

Diseases related to Familial Acute Myeloid Leukemia with Mutated Cebpa via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 cebpa-associated familial acute myeloid leukemia 11.3
2 pelger-huet anomaly 9.7

Symptoms & Phenotypes for Familial Acute Myeloid Leukemia with Mutated Cebpa

Drugs & Therapeutics for Familial Acute Myeloid Leukemia with Mutated Cebpa

Drugs for Familial Acute Myeloid Leukemia with Mutated Cebpa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cytarabine Approved, Investigational Phase 1, Phase 2 147-94-4 6253
2
ponatinib Approved Phase 1, Phase 2 943319-70-8 24826799
3 PONATINIB  Phase 1, Phase 2
4 Anti-Infective Agents Phase 1, Phase 2
5 Immunosuppressive Agents Phase 1, Phase 2
6 Protein Kinase Inhibitors Phase 1, Phase 2
7 Antimetabolites Phase 1, Phase 2
8 Antimetabolites, Antineoplastic Phase 1, Phase 2
9 Antiviral Agents Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Ponatinib for FLT3-ITD Acute Myelogenous Leukemia Recruiting NCT02428543 Phase 1, Phase 2
2 Next Generation Sequencing (NGS) in Familial Acute Myeloid Leukemia and Myelodisplastic Syndromes Recruiting NCT03058588
3 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268
4 Studying Tissue and Blood Samples From Patients With Acute Myeloid Leukemia Active, not recruiting NCT00900224

Search NIH Clinical Center for Familial Acute Myeloid Leukemia with Mutated Cebpa

Genetic Tests for Familial Acute Myeloid Leukemia with Mutated Cebpa

Genetic tests related to Familial Acute Myeloid Leukemia with Mutated Cebpa:

id Genetic test Affiliating Genes
1 Familial Acute Myeloid Leukemia (aml) with Mutated Cebpa 24 CEBPA

Anatomical Context for Familial Acute Myeloid Leukemia with Mutated Cebpa

MalaCards organs/tissues related to Familial Acute Myeloid Leukemia with Mutated Cebpa:

39
Myeloid, Bone, Bone Marrow

Publications for Familial Acute Myeloid Leukemia with Mutated Cebpa

Variations for Familial Acute Myeloid Leukemia with Mutated Cebpa

Expression for Familial Acute Myeloid Leukemia with Mutated Cebpa

Search GEO for disease gene expression data for Familial Acute Myeloid Leukemia with Mutated Cebpa.

Pathways for Familial Acute Myeloid Leukemia with Mutated Cebpa

GO Terms for Familial Acute Myeloid Leukemia with Mutated Cebpa

Sources for Familial Acute Myeloid Leukemia with Mutated Cebpa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....