FAP
MCID: FML011
MIFTS: 80

Familial Adenomatous Polyposis (FAP) malady

Neuronal, Eye, Gastrointestinal, Skin, Fetal, Cancer, Genetic categories

Summaries for Familial Adenomatous Polyposis

Sources:
8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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Genetics Home Reference:21 Familial adenomatous polyposis (FAP) is an inherited disorder characterized by cancer of the large intestine (colon) and rectum. People with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) growths (polyps) in the colon as early as their teenage years. Unless the colon is removed, these polyps will become malignant (cancerous). The average age at which an individual develops colon cancer in classic familial adenomatous polyposis is 39 years. Some people have a variant of the disorder, called attenuated familial adenomatous polyposis, in which polyp growth is delayed. The average age of colorectal cancer onset for attenuated familial adenomatous polyposis is 55 years.

MalaCards: Familial Adenomatous Polyposis, also known as adenomatous polyposis coli, is related to adenoma and desmoid tumor, and has symptoms including autosomal dominant inheritance, irregular/in bands/reticular skin hyperpigmentation and delayed dentition/eruption of teeth/lack of eruption of teeth. An important gene associated with Familial Adenomatous Polyposis is APC (adenomatous polyposis coli), and among its related pathways are Pathways in cancer and Wnt signaling pathway. The drug celecoxib and the compounds glycogen and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are cellular and mortality/aging.

Disease Ontology:8 An autosomal dominant disease that is caused by mutations in the apc gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

NIH Rare Diseases:43 Familial adenomatous polyposis (fap) is an inherited colorectal cancer syndrome. cancer usually develops in the lower part of the digestive system, including the large intestine (colon) and rectum. people with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) polyps (growths) in the colon as early as their teenage years. the average age at which an individual develops colon cancer in classic familial adenomatous polyposis is about 39 years. mutations in the apc gene cause classic familial adenomatous polyposis. last updated: 4/6/2010

Wikipedia:64 Familial adenomatous polyposis (FAP) is an inherited condition in which numerous polyps form mainly in... more...

Description from OMIM:47 608456,175100

Aliases & Classifications for Familial Adenomatous Polyposis

Sources:
8Disease Ontology, 64Wikipedia, 43NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 10DISEASES, 45Novoseek, 49Orphanet, 22GTR, 47OMIM, 61UMLS, 35MeSH, 26ICD10 via Orphanet, 36MESH via Orphanet, 62UMLS via Orphanet, 58SNOMED-CT via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal, Cancer, Genetic
Anatomical: Neuronal, Eye, Gastrointestinal, Skin


Characteristics (Orphanet epidemiological data):

49
familial adenomatous polyposis:
Inheritance: Autosomal dominant,Autosomal recessive; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult
attenuated familial adenomatous polyposis:
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Adulthood


Aliases & Descriptions:

familial adenomatous polyposis 8 64 43 20 21 10 45 49
adenomatous polyposis coli 64 43 22 21 47 61
adenomatous polyposis of the colon 8 64 43
fap 64 21 49
familial multiple polyposis 43 22
myh-associated polyposis 21 61
gardner syndrome 49 61
apc-related attenuated familial adenomatous polyposis 49
apc-related attenuated familial polyposis coli 49
familial adenomatous polyposis of the colon 43
familial adenomatous polyposis, attenuated 61
attenuated familial adenomatous polyposis 49
adenomatous familial polyposis syndrome 21
familial multiple polyposis syndrome 21
attenuated familial polyposis coli 49
colorectal adenomatous polyposis 49
adenomatous familial polyposis 21
turcot syndrome with polyposis 49
familial intestinal polyposis 43
apc-related attenuated fap 49
atrial premature complexes 61
hereditary polyposis coli 64
familial polyposis coli 49
colon cancer, familial 64
apc-related afap 49
polyposis coli 64
attenuated fap 49
afap 49


External Ids:

Disease Ontology8 DOID:0050424
MeSH35 D011125
ICD10 via Orphanet26 D12.6
MESH via Orphanet36 C538265, D005736
UMLS via Orphanet62 C2674616, C0017097
SNOMED-CT via Orphanet58 60876000

Related Diseases for Familial Adenomatous Polyposis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Familial Adenomatous Polyposis family:

familial adenomatous polyposis due to 5q22.2 microdeletion

Diseases related to Familial Adenomatous Polyposis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma32.4SMPD1, ENPP7, PTGS2, PTGER2, MSH2, MSH6
2desmoid tumor31.4APC, CTNNB1
3colorectal cancer31.3ODC1, OGG1, APC, CTNNB1, MUTYH, MSH6
4familial colorectal cancer31.3APC, MSH6, MSH2
5adenocarcinoma31.2ODC1, KLF4, OGG1, APC, CTNNB1, PLA2G2A
6gardner syndrome31.0APC, CTNNB1
7hepatocellular adenoma31.0APC, CTNNB1
8thyroid cancer30.9APC
9turcot syndrome30.9MSH6, MSH2
10squamous cell carcinoma30.8ODC1, KLF4, OGG1, APC, CTNNB1, WNT1
11fibromatosis30.6CTNNB1, APC
12juvenile polyposis syndrome30.6APC
13peutz-jeghers syndrome30.5CTNNB1, APC
14stomach cancer30.4ODC1, APC, CTNNB1, PTGS2
15muir-torre syndrome30.3MSH2, MSH6
16gastric cancer, somatic30.3APC, MUTYH
17arthritis30.2PTGS2, PLA2G2A
18astrocytoma30.1MSH2, PLA2G2A
19attenuated familial adenomatous polyposis11.1
20thyroid adenoma10.9
21ulcerative colitis10.8
22breast adenoma10.8
23papillary adenoma10.7
24pancreatic adenoma10.7
25cap polyposis10.7
26papillary carcinoma10.7
27familial papillary thyroid carcinoma10.6
28gastrointestinal adenoma10.5
29adrenal adenoma10.5
30pouchitis10.5
31oral squamous cell carcinoma10.5
32cribriform carcinoma10.5
33n syndrome10.5
34familial adenomatous polyposis due to 5q22.2 microdeletion10.5
35acute pancreatitis10.4
36mutyh-associated polyposis10.4
37adenomas, multiple colorectal10.4
38juvenile nasopharyngeal angiofibroma10.4
39colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas10.4
40samson gardner syndrome10.4
41transthyretin amyloidosis10.4
42clear cell adenoma10.3
43pulmonary sclerosing hemangioma10.3
44gastrointestinal stromal tumor10.3
45peutz–jeghers syndrome10.3
46mental retardation10.3
47familial hemangioma10.3
48gastrointestinal stromal tumor, familial10.3
49endotheliitis10.3
50parathyroid carcinoma10.3

Graphical network of the top 20 diseases related to Familial Adenomatous Polyposis:



Diseases related to familial adenomatous polyposis

Clinical Features for Familial Adenomatous Polyposis

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

608456,175100

Clinical synopsis from OMIM:

175100

Symptoms:

49 (show all 12)
  • autosomal dominant inheritance
  • irregular/in bands/reticular skin hyperpigmentation
  • delayed dentition/eruption of teeth/lack of eruption of teeth
  • xanthomas/lipomas
  • neoplasms/tumors
  • polyposis of the bowel/colon/intestine
  • colon neoplasm/tumor/carcinoma/cancer
  • supernumerary teeth/polyodontia
  • dental cysts/tumors
  • fibromatosis/bone fibroma
  • sarcoma
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Familial Adenomatous Polyposis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Familial Adenomatous Polyposis

Drug clinical trials:

Search ClinicalTrials for Familial Adenomatous Polyposis

Search NIH Clinical Center for Familial Adenomatous Polyposis

Search CenterWatch for Familial Adenomatous Polyposis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Familial Adenomatous Polyposis

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Familial Adenomatous Polyposis:

id Genetic test Affiliating Genes
1 Familial Adenomatous Polyposis20
2 Adenomatous Polyposis Coli22
3 Familial Multiple Polyposis Syndrome22

Anatomical Context for Familial Adenomatous Polyposis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Familial Adenomatous Polyposis:

33
Skin, Liver, Brain, Kidney, Lung, Spleen, Small intestine, Colon, Pancreas, Thyroid, Adrenal gland, Testis, T cells, Testis germ

Animal Models for Familial Adenomatous Polyposis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Familial Adenomatous Polyposis

Sources:
51PubMed
See all sources

Articles related to Familial Adenomatous Polyposis:

(show top 50)    (show all 745)
idTitleAuthorsYear
1
Prospective enteroscopic evaluation of jejunal polyposis in patients with familial adenomatous polyposis and advanced duodenal polyposis. (23054214)
2013
2
Barrett's esophagus in the patients with familial adenomatous polyposis. (23771323)
2013
3
Rectal cancers in patients with familial adenomatous polyposis. (23677695)
2013
4
Familial adenomatous polyposis of the colon. (24148210)
2013
5
Imaging assessment of desmoid tumours in familial adenomatous polyposis: is state-of-the-art 1.5 T MRI better than 64-MDCT? (22215881)
2012
6
Portal vein thrombosis after restorative proctocolectomy for familial adenomatous polyposis and sigmoid cancer. (22532810)
2012
7
Genotypes and phenotypes: animal models of familial adenomatous polyposis coli. (23010297)
2012
8
Effects of celecoxib on prostanoid biosynthesis and circulating angiogenesis proteins in familial adenomatous polyposis. (22262921)
2012
9
Deep intronic APC mutations explain a substantial proportion of patients with familial or early-onset adenomatous polyposis. (22431159)
2012
10
Successful treatment of an intra-abdominal desmoid tumor with irinotecan, fluorouracil, and leucovorin plus bevacizumab in a patient with familial adenomatous polyposis. (21533592)
2012
11
Progression of duodenal adenomatosis in familial adenomatous polyposis: due to ageing of subjects and advances in technology. (21416262)
2011
12
Psychological distress and quality of life of partners of individuals with familial adenomatous polyposis. (20198719)
2011
13
A new phenotypic manifestation of familial adenomatous polyposis. (21547505)
2011
14
Familial adenomatous polyposis and desmoid tumors. (22012061)
2011
15
A nation-wide study comparing sporadic and familial adenomatous polyposis-related desmoid-type fibromatoses. (20830713)
2011
16
Familial adenomatous polyposis coli. (21874800)
2011
17
Quality of life and consequences for daily life of familial adenomatous polyposis (FAP) family members. (20402739)
2011
18
Cell transplantation in surgical treatment of familial adenomatous polyposis coli. (22268056)
2011
19
Evaluation of 28 years of surgical treatment of children and young adults with familial adenomatous polyposis. (20223315)
2010
20
Familial adenomatous polyposis and hypertension. (20472175)
2010
21
Inactivation of the APC gene is constant in adrenocortical tumors from patients with familial adenomatous polyposis but not frequent in sporadic adrenocortical cancers. (20978149)
2010
22
Gene variants associated to malignant thyroid disease in familial adenomatous polyposis: a novel APC germline mutation. (20935450)
2010
23
Risk factors for secondary proctectomy in patients with familial adenomatous polyposis. (20665483)
2010
24
Surgical prophylaxis in familial adenomatous polyposis: do pre-existing desmoids outside the abdominal cavity matter? (20428953)
2010
25
Familial adenomatous polyposis-associated ampullary adenoma: response to chemotherapy for concurrent metastatic adenocarcinoma. (19245848)
2009
26
Rectal and pouch recurrences after surgical treatment for familial adenomatous polyposis. (18766422)
2009
27
Combination chemoprevention of intestinal carcinogenesis in a murine model of familial adenomatous polyposis. (19003578)
2008
28
Attitudes toward prenatal genetic testing in patients with familial adenomatous polyposis. (17355417)
2007
29
Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): a review of the literature. (17064931)
2007
30
Pulmonary sclerosing hemangioma detected by fluorodeoxyglucose positron emission tomography in familial adenomatous polyposis: report of a case. (17473941)
2007
31
Does early colectomy increase desmoid risk in familial adenomatous polyposis? (17916546)
2007
32
Familial adenomatous polyposis complicated with an invasive colo-rectal adenocarcinoma in a 26-year-old Nigerian male - a rare finding. (17371432)
2007
33
Ability of FDG-PET to detect all cancers in patients with familial adenomatous polyposis, and impact on clinical management. (16292630)
2006
34
Defensin expression in chronic pouchitis in patients with ulcerative colitis or familial adenomatous polyposis coli. (16534846)
2006
35
Dietary putrescine reduces the intestinal anticarcinogenic activity of sulindac in a murine model of familial adenomatous polyposis. (17474863)
2006
36
Genetic polymorphisms of flavin monooxygenase 3 in sulindac-induced regression of colorectal adenomas in familial adenomatous polyposis. (16214918)
2005
37
APC genotype is not a prognostic factor in familial adenomatous polyposis patients with colorectal cancer. (15540296)
2004
38
Genetic alterations in hepatoblastoma and hepatocellular carcinoma associated with familial adenomatous polyposis. (14515405)
2003
39
APC haploinsufficiency, but not CTNNB1 or CDH1 gene mutations, accounts for a fraction of familial adenomatous polyposis patients without APC truncating mutations. (14691304)
2003
40
Expression of COX-2 and Wnt pathway genes in adenomas of familial adenomatous polyposis patients treated with meloxicam. (12174906)
2002
41
Effect of sulindac treatment for attenuated familial adenomatous polyposis with a new germline APC mutation at codon 161: report of a case. (12394442)
2002
42
Fundic gland polyposis with high-grade dysplasia in a child with attenuated familial adenomatous polyposis and familial gastric cancer. (11321399)
2001
43
Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. (11522744)
2001
44
Mucosal prostanoid receptors and synthesis in familial adenomatous polyposis. (11685545)
2001
45
Marfan-like habitus and familial adenomatous polyposis in two unrelated males: a significant association? (10439970)
1999
46
Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. (8988060)
1997
47
Familial adenomatous polyposis and thyroid cancer]. (9091394)
1997
48
Desmoids in familial adenomatous polyposis. (9014661)
1996
49
Attenuated familial adenomatous polyposis due to a mutation in the 3' part of the APC gene. A clue for understanding the function of the APC protein. (8655134)
1996
50
Thymidine kinase activity in familial adenomatous polyposis. (1339104)
1992

Genetic Variations for Familial Adenomatous Polyposis

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Familial Adenomatous Polyposis:

63 (show all 12)
id Symbol AA change Variation SNP ID
1APCp.Ser171IleVAR_005032
2APCp.Arg414CysVAR_005033rs137854567
3APCp.Ser784ThrVAR_005034
4APCp.Glu911GlyVAR_005038
5APCp.Pro1176LeuVAR_005044
6APCp.Thr1313AlaVAR_005051
7APCp.Arg1348TrpVAR_005053
8APCp.Ser2621CysVAR_005056rs72541816
9APCp.Leu2839PheVAR_005057
10APCp.Arg99TrpVAR_009613
11APCp.Ser722GlyVAR_009614
12APCp.Ala1184ProVAR_009616

Expression for genes affiliated with Familial Adenomatous Polyposis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Familial Adenomatous Polyposis

Search GEO for disease gene expression data for Familial Adenomatous Polyposis.

Pathways for genes affiliated with Familial Adenomatous Polyposis

Sources:
30KEGG, 53R&D Systems, 38NCBI BioSystems Database, 60Tocris Bioscience, 12EMD Millipore, 52QIAGEN, 4Cell Signaling Technology, 50PharmGKB, 56SinoBiological, 54Reactome
See all sources

Pathways related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9APC, APC2, CTNNB1, AXIN2, WNT2, WNT1
2
Hide members
10.8CSNK1E, APC, APC2, CTNNB1, AXIN2, WNT2
310.8CSNK1E, APC, APC2, CTNNB1, AXIN2, WNT2
4
Hide members
10.8CSNK1E, APC, APC2, CTNNB1, AXIN2, WNT2
5
Hide members
10.8APC, APC2, CTNNB1, AXIN2, MSH6, MSH2
610.8CSNK1E, APC, CTNNB1, WNT2, WNT1, PTGS2
7
Hide members
10.8CSNK1E, APC, CTNNB1, AXIN2, WNT2, WNT1
8
Hide members
10.7WNT1, WNT2, CTNNB1, APC, CSNK1E
910.7KLF4, CSNK1E, APC, CTNNB1, AXIN2
1010.7APC, APC2, CTNNB1, WNT2, WNT1
1110.7PTGER2, MSH6, WNT2, AXIN2, APC
1210.7PTGS2, PTGER2, PLA2G2A, CTNNB1
1310.7CSNK1E, APC, CTNNB1, AXIN2
1410.7APC, CTNNB1, WNT2, WNT1
15
Hide members
10.7APC, CTNNB1, WNT2, WNT1
1610.7APC, CTNNB1, WNT2, WNT1
1710.7WNT1, WNT2, CTNNB1, APC
1810.7KLF4, APC, CTNNB1, AXIN2
19
Hide members
10.7CSNK1E, CTNNB1, WNT2, WNT1
2010.6WNT1, CTNNB1, APC
2110.6WNT1, AXIN2, CTNNB1
22
Transcription Androgen Receptor nuclear signaling
Hide members
10.6WNT1, WNT2, CTNNB1
23
Hide members
10.6OGG1, MUTYH
2410.6ENPP7, SMPD1

Compounds for genes affiliated with Familial Adenomatous Polyposis

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1glycogen45 2412.2CSNK1E, APC, CTNNB1, AXIN2, WNT2, WNT1
2h2o24511.2ODC1, OGG1, CTNNB1, MUTYH, NUDT1, PLA2G2A
3adenine45 11 2413.2ODC1, OGG1, APC, MUTYH, NUDT1, MSH2
4serine4511.2CSNK1E, APC, AXIN2, PLA2G2A, MSH2, SMPD1
5threonine4511.2FMO3, CSNK1E, APC, CTNNB1, AXIN2, MSH6
6aspirin45 50 29 2414.2ODC1, APC, CTNNB1, PLA2G2A, PTGER2, PTGS2
7paraffin4511.2ODC1, APC, CTNNB1, WNT2, MSH6, MSH2
8crcs4511.2PTGER2, MSH2, MSH6, CTNNB1, APC
9sulindac45 1112.2ODC1, FMO3, APC, CTNNB1, PTGS2
10dopamine45 29 11 2414.1ODC1, OGG1, APC, CTNNB1, PLA2G2A
118-oxoguanine4511.1OGG1, APC, MUTYH, NUDT1
12methionine4511.1ODC1, FMO3, APC, NUDT1, SMPD1
13samp4511.1AXIN2, CTNNB1, APC
148-oxo-dgtp45 2412.1NUDT1, MUTYH, OGG1
15nmda45 2912.1ODC1, APC, CTNNB1, PLA2G2A, PTGER2
16oligonucleotide4511.1KLF4, OGG1, APC, CTNNB1, WNT1, SMPD1
171,2-dimethylhydrazine4511.1CTNNB1, APC, ODC1
18n-methyl-n-nitrosourea4511.0CTNNB1, MSH6, MSH2
19azoxymethane4511.0ODC1, APC, CTNNB1
20exisulind4511.0APC, CTNNB1, PTGS2
21mononucleotide4511.0MSH2, MSH6, APC
22doxorubicin45 50 1113.0ODC1, CTNNB1, MSH6, MSH2, SMPD1
23biotin45 11 2413.0MSH2, MSH6, CTNNB1, KLF4
24mnng4511.0APC, MSH2, SMPD1
25phosphorylcholine45 2412.0SMPD1, ENPP7, PLA2G2A
268-oxo-dg4511.0OGG1, MUTYH, NUDT1
27pge24511.0PTGS2, SMPD1
28gf 109203x45 6012.0CTNNB1, PLA2G2A, PTGER2, PTGS2
29arachidonic acid45 29 11 2414.0CTNNB1, PLA2G2A, PTGER2, PTGS2, SMPD1
30oxygen45 2412.0FMO3, OGG1, WNT2, SMPD1
31o6-methylguanine4511.0MSH2, MSH6, APC
32methylazoxymethanol acetate4511.0APC, CTNNB1
331-hydroxyanthraquinone4511.0APC, CTNNB1
34af/ap4510.9APC, MUTYH
35pidotimod4510.9CTNNB1, AXIN2
36lysophosphatidylcholine45 2911.9ENPP7, PLA2G2A, APC
37curcumin4510.9ODC1, APC, CTNNB1, PTGS2
38glutamate4510.9WNT1
39ndga4510.9ODC1, PLA2G2A, PTGS2
40prostacyclin4510.9APC, PLA2G2A, PTGER2, PTGS2
41pgd24510.9PLA2G2A, PTGER2, PTGS2
428-hydroxyguanine4510.8OGG1, MUTYH
43ah 68094510.7PTGER2, PTGS2
44cisplatin45 50 60 1113.7SMPD1, PTGS2, MSH2, MSH6, CTNNB1
45prostaglandin4510.7PTGER2, ODC1
46diclofenac45 29 50 1113.7CTNNB1, PLA2G2A, PTGS2
47ah2384845 2911.7PTGS2, PTGER2
48nitric oxide45 11 2412.7ODC1, KLF4, OGG1, PTGER2, PTGS2, SMPD1
49tyrosine4510.6ODC1, APC, CTNNB1, WNT2, WNT1, MSH6
50guanine45 11 2412.5MUTYH

GO Terms for genes affiliated with Familial Adenomatous Polyposis

Sources:
16Gene Ontology
See all sources

Cellular components related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.6AXIN2, CTNNB1, APC
2catenin complexGO:01634210.6CTNNB1, APC2
3MutSalpha complexGO:03230110.5MSH2, MSH6
4cytoplasmic microtubuleGO:00588110.3APC, APC2, AXIN2

Biological processes related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1DNA repairGO:00628111.2OGG1, CSNK1E, MUTYH, NUDT1, MSH6, MSH2
2negative regulation of cell proliferationGO:00828511.1KLF4, APC, CTNNB1, AXIN2, PTGS2, ENPP7
3canonical Wnt receptor signaling pathwayGO:06007011.0WNT1, WNT2, CTNNB1, APC
4small molecule metabolic processGO:04428111.0ODC1, FMO3, NUDT1, PLA2G2A, PTGS2, ENPP7
5maintenance of DNA repeat elementsGO:04357011.0MSH2, MSH6, AXIN2
6mismatch repairGO:00629811.0MUTYH, MSH6, MSH2
7Wnt receptor signaling pathwayGO:01605511.0APC2, CTNNB1, WNT2, WNT1
8T cell differentiation in thymusGO:03307711.0WNT1, CTNNB1, APC
9canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic processGO:04433610.9WNT1, CTNNB1
10regulation of centromeric sister chromatid cohesionGO:07060210.9CTNNB1, AXIN2
11depurinationGO:04500710.9OGG1, MUTYH
12lung inductionGO:06049210.9CTNNB1, WNT2
13response to estradiol stimulusGO:03235510.9PTGS2, CTNNB1, OGG1
14meiotic mismatch repairGO:00071010.9MSH2, MSH6
15sphingomyelin metabolic processGO:00668410.9SMPD1, ENPP7
16positive regulation of helicase activityGO:05109610.9MSH6, MSH2
17somatic recombination of immunoglobulin gene segmentsGO:01644710.9MSH6, MSH2
18negative regulation of DNA recombinationGO:04591010.8MSH2, MSH6
19base-excision repair, AP site formationGO:00628510.8OGG1, MUTYH
20embryonic axis specificationGO:00057810.8CTNNB1, WNT1
21positive regulation of apoptotic processGO:04306510.8APC, CTNNB1, PTGS2, SMPD1
22negative regulation of catenin import into nucleusGO:03541410.8AXIN2, APC2
23negative regulation of canonical Wnt receptor signaling pathwayGO:09009010.8AXIN2, APC2, APC
24dorsal/ventral axis specificationGO:00995010.7CTNNB1, AXIN2
25response to drugGO:04249310.7OGG1, CTNNB1, PTGS2, SMPD1
26somatic hypermutation of immunoglobulin genesGO:01644610.6MSH2, MSH6
27isotype switchingGO:04519010.6MSH2, MSH6
28response to oxidative stressGO:00697910.5PTGS2, NUDT1, OGG1
29determination of adult lifespanGO:00834010.3MSH2, MSH6

Molecular functions related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.0OGG1, CSNK1E, APC, APC2, CTNNB1, MUTYH
2double-stranded DNA bindingGO:00369011.0MSH2, MSH6, CTNNB1, KLF4
3MutLalpha complex bindingGO:03240510.9MSH2, MSH6, MUTYH
4single thymine insertion bindingGO:03214310.9MSH6, MSH2
5single guanine insertion bindingGO:03214210.8MSH2, MSH6
6oxidized purine DNA bindingGO:03235710.8MSH2, MSH6
7beta-catenin bindingGO:00801310.8AXIN2, APC2, APC
8guanine/thymine mispair bindingGO:03213710.8MSH6, MSH2
9four-way junction DNA bindingGO:00040010.8MSH6, MSH2
10enzyme bindingGO:01989910.8CTNNB1, AXIN2, MSH2, PTGS2
11sphingomyelin phosphodiesterase activityGO:00476710.7ENPP7, SMPD1
12hydrolase activity, acting on glycosyl bondsGO:01679810.7SMPD1, MUTYH
13I-SMAD bindingGO:07041110.6AXIN2, CTNNB1
14mismatched DNA bindingGO:03098310.6MSH2, MSH6
15protein kinase bindingGO:01990110.6APC, CTNNB1, AXIN2, MSH2
16receptor agonist activityGO:04801810.3WNT1, WNT2

Products for genes affiliated with Familial Adenomatous Polyposis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Familial Adenomatous Polyposis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet