MCID: FML011
MIFTS: 65

Familial Adenomatous Polyposis malady

Genetic diseases, Rare diseases, Gastrointestinal diseases, Cancer diseases categories

Aliases & Classifications for Familial Adenomatous Polyposis

About this section
Sources:
10Disease Ontology, 68Wikipedia, 45NIH Rare Diseases, 22GeneTests, 23Genetics Home Reference, 47Novoseek, 12DISEASES, 51Orphanet, 24GTR, 36MeSH, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Familial Adenomatous Polyposis:

Name: Familial Adenomatous Polyposis 10 68 45 22 23 47 12 51
Adenomatous Polyposis Coli 68 45 22 23 36
Fap 68 45 22 23 51
Adenomatous Polyposis of the Colon 10 68 45
Familial Multiple Polyposis Syndrome 23 24
Hereditary Polyposis Coli 68 45
Familial Polyposis Coli 22 51
Familial Adenomatous Polyposis of the Colon 45
Adenomatous Familial Polyposis Syndrome 23
Polyposis, Adenomatous Intestinal 45
 
Colorectal Adenomatous Polyposis 51
Familial Polyposis of the Colon 45
Adenomatous Familial Polyposis 23
Familial Intestinal Polyposis 45
Familial Multiple Polyposis 45
Myh-Associated Polyposis 23
Colon Cancer, Familial 68
Polyposis Coli 68
Fpc 45


Classifications:



Characteristics (Orphanet epidemiological data):

51
familial adenomatous polyposis:
Inheritance: Autosomal dominant,Autosomal recessive; Prevalence: 1-9/100000 (Europe); Age of onset: Adult; Age of death: adult


External Ids:

Disease Ontology10 DOID:0050424
MeSH36 D011125
Orphanet51 733
ICD10 via Orphanet28 D12.6
MESH via Orphanet37 D011125
UMLS via Orphanet66 C0032580

Summaries for Familial Adenomatous Polyposis

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NIH Rare Diseases:45 Familial adenomatous polyposis (fap) is an inherited condition that causes cancer of the large intestine (colon) and rectum. people with the classic type of fap usually develop hundreds to thousands of noncancerous (benign) polyps (growths) in the colon as early as their teenage years. overtime, these polyps can become malignant (cancerous), leading to early-onset colorectal cancer at an average age of 39 years. other signs and symptoms may include dental abnormalities; desmoid tumors; and benign and malignant tumors of the duodenum (a section of the small intestine), stomach, bones, skin, and other tissues. some people have a milder form of the condition called attenuated familial adenomatous polyposis (afap) which is generally characterized by fewer colon polyps (an average of 30) and a delay in the development of colon cancer by 10-15 years. fap is caused by changes (mutations) in the apc gene and is inherited in an autosomal dominant manner. people with fap usually undergo regular screening until they develop 20 to 30 polyps and then a colectomy (removal of colon) is generally recommended. last updated: 11/26/2014

MalaCards based summary: Familial Adenomatous Polyposis, also known as adenomatous polyposis coli, is related to colonic disease and gastrointestinal system cancer, and has symptoms including polyposis of the bowel/colon/intestine, autosomal dominant inheritance and neoplasms/tumors. An important gene associated with Familial Adenomatous Polyposis is APC (Adenomatous Polyposis Coli), and among its related pathways are E-cadherin signaling in the nascent adherens junction and Gastric cancer network 2. The drug celecoxib has been mentioned in the context of this disorder. Affiliated tissues include colon, bone and skin, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Disease Ontology:10 An autosomal dominant disease that is caused by mutations in the apc gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

Genetics Home Reference:23 Familial adenomatous polyposis (FAP) is an inherited disorder characterized by cancer of the large intestine (colon) and rectum. People with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) growths (polyps) in the colon as early as their teenage years. Unless the colon is removed, these polyps will become malignant (cancerous). The average age at which an individual develops colon cancer in classic familial adenomatous polyposis is 39 years. Some people have a variant of the disorder, called attenuated familial adenomatous polyposis, in which polyp growth is delayed. The average age of colorectal cancer onset for attenuated familial adenomatous polyposis is 55 years.

Wikipedia:68 Familial adenomatous polyposis (FAP) is an inherited condition in which numerous adenomatous polyps form... more...

Related Diseases for Familial Adenomatous Polyposis

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Diseases in the Familial Adenomatous Polyposis family:

Familial Adenomatous Polyposis 3

Diseases related to Familial Adenomatous Polyposis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 426)
idRelated DiseaseScoreTop Affiliating Genes
1colonic disease31.3APC, CTNNB1, MAPRE1, MLH1, MUTYH, PTGS2
2gastrointestinal system cancer30.9APC, CCND1, CTNNB1, KRAS, MLH1, MUTYH
3intestinal disease30.8APC, CCND1, CTNNB1, KRAS, MLH1, MSH2
4adenomatous polyposis coli30.6APC, APC2, AXIN1, CCND1, CDH1, CTNNB1
5medulloblastoma30.6APC, AXIN1, CTNNB1, MYC, TP53
6gastric cancer, somatic30.4APC, CDH1, KRAS, MUTYH
7muir-torre syndrome30.3MLH1, MSH2, MSH6, MUTYH
8mismatch repair cancer syndrome30.2APC, CTNNB1, MLH1, MSH2, MSH6
9stomach disease30.1CCND1, CDH1, CTNNB1, KRAS, MLH1, PTGS2
10autosomal genetic disease30.1MLH1, MSH2, MSH6, SMAD4, TP53
11hepatocellular carcinoma30.0APC, AXIN1, CCND1, CDH1, CTNNB1, HNF4A
12gastrointestinal system disease30.0APC, CCND1, CDH1, CTNNB1, KRAS, MLH1
13common variable immunodeficiency29.9APC, CTNNB1, KRAS, MLH1, MSH2, MUTYH
14pancreatic ductal adenocarcinoma29.8CDH1, KRAS, SMAD4, TP53
15breast cancer29.7APC, CCND1, CDH1, CTNNB1, KRAS, MLH1
16colorectal cancer29.1APC, AXIN1, CCND1, CDH1, CTNNB1, GSK3B
17adenoma11.2
18attenuated familial adenomatous polyposis11.1
19duodenitis11.1
20desmoid tumor11.0
21colorectal adenoma11.0
22mutyh-associated polyposis11.0
23colon adenoma10.9
24colitis10.9
25thyroiditis10.9
26familial colorectal cancer10.9
27hereditary colorectal cancer10.9
28ulcerative colitis10.9
29gastrointestinal adenoma10.9
30colonic benign neoplasm10.9
31intestinal benign neoplasm10.9
32adenocarcinoma10.9
33familial adenomatous polyposis 310.9
34duodenal disease10.8
35colorectal cancer 210.8
36inflammatory bowel disease 210.8
37central nervous system cancer10.8
38nervous system cancer10.8
39peripheral nervous system neoplasm10.8
40hereditary peripheral nervous disorder10.8
41colorectal cancer 310.8
42duodenum adenoma10.8
43duodenal benign neoplasm10.8
44lynch syndrome10.8
45colorectal cancer 110.7
46large intestine cancer10.7
47inflammatory bowel disease 310.7
48hemorrhoid10.7
49hepatoblastoma10.7
50rectal disease10.7

Graphical network of the top 20 diseases related to Familial Adenomatous Polyposis:



Diseases related to familial adenomatous polyposis

Symptoms for Familial Adenomatous Polyposis

About this section

Symptoms:

 51 (show all 12)
  • polyposis of the bowel/colon/intestine
  • autosomal dominant inheritance
  • neoplasms/tumors
  • colon neoplasm/tumor/carcinoma/cancer
  • supernumerary teeth/polyodontia
  • delayed dentition/eruption of teeth/lack of eruption of teeth
  • dental cysts/tumors
  • irregular/in bands/reticular skin hyperpigmentation
  • xanthomas/lipomas
  • fibromatosis/bone fibroma
  • sarcoma
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Familial Adenomatous Polyposis

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Drugs for Familial Adenomatous Polyposis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Celecoxibapproved, investigationalPhase 4, Phase 2, Phase 3, Phase 1395169590-42-52662
Synonyms:
169590-42-5
184007-95-2
1oq5
4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1Hpyrazol-1-yl] benzenesulfonamide
4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
AC-4228
AC1L1E6K
AI-525
BIDD:GT0408
BRD-K02637541-001-02-4
BSPBio_003596
Benzenesulfonamide,4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)
C07589
C105934
C17H14F3N3O2S
CCRIS 8679
CEL
CEP-33222
CHEBI:41423
CHEMBL118
CID2662
CPD000550473
Celebra
Celebrex
Celebrex (TN)
Celebrex, Celebra, Celecoxib
Celecox
Celecoxi
Celecoxib
Celecoxib (JAN/USAN/INN)
Celecoxib (SC-58635)
Celecoxib [Old RN]
Celecoxib [USAN]
Celecoxibum
Celocoxib
Célécoxib
D00567
DB00482
DivK1c_000893
Eurocox
FT-0080064
HMS1922G14
HMS2089L18
HMS2093I07
HMS502M15
HSDB 7038
I01-1033
IDI1_000893
KBio1_000893
KBio2_000912
 
KBio2_002351
KBio2_003480
KBio2_004919
KBio2_006048
KBio2_007487
KBio3_002830
KBio3_003037
KBioGR_000723
KBioGR_002351
KBioSS_000912
KBioSS_002354
LS-31667
MLS001165684
MLS001195656
MLS001304708
Medicoxib
MolPort-002-885-815
NCGC00091455-01
NCGC00091455-02
NCGC00091455-03
NCGC00091455-04
NCI60_041049
NINDS_000893
NSC719627
Onsenal
P-(5-P-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide
Pfizer brand of celecoxib
S1261_Selleck
SAM002589995
SC 58635
SC-58553, SC-58635
SC-58635
SC58635
SMR000550473
SPBio_001512
SPECTRUM1503678
Solexa
Spectrum2_001576
Spectrum3_001996
Spectrum4_000182
Spectrum5_001324
Spectrum_000432
TL8001323
TPI-336
UNM-0000305813
Xilebao
YM 177
YM-177
YM177
ZINC02570895
cMAP_000027
celecoxib
p-(5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide
2
ErythromycinapprovedPhase 485114-07-812560
Synonyms:
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione
,10-dione
114-07-8
3''-O-demethylerythromycin
374700-25-1
45673_FLUKA
45674_FLUKA
79235-06-6
82343-12-2
A/T/S
AC-12744
AC1L1FIQ
AC1L1QK7
AC1L1ZUR
AC1O8PVA
AC1Q2UA1
AC1Q6O1S
AI3-50138
AR-1A4414
AR-1H0723
Abboticin
Abomacetin
Acneryne
Acnesol
Ak-Mycin
Ak-mycin
Akne Cordes Losung
Akne-Mycin
Akne-mycin
Akne-mycin (TN)
Aknederm Ery Gel
Aknemycin
Aknin
AustriaS
BB_NC-1332
BIDD:GT0017
BPBio1_000312
BSPBio_000282
BSPBio_002480
Benzamycin
Benzamycin Pak
Bristamycin
C-Solve-2
C01912
C37H67NO13
CCRIS 9078
CHEBI:42355
CHEMBL532
CID12560
CID3255
CID6713919
CID8233
D00140
DB00199
Del-Mycin
Derimer
Deripil
DivK1c_000294
DivK1c_000397
DivK1c_000702
Dotycin
Dumotrycin
E- mycin, Erycin, Robimysin
E-Base
E-Base (base)
E-Glades
E-Mycin
E-Mycin (base)
E-Solve 2
E.e.s
E.e.s.
E0751
E0774_SIAL
E5389_SIGMA
E6376_SIAL
E7904_SIGMA
EINECS 204-040-1
EM
EMU
ERY
ERYC
ERYC (base)
ERYTHROMYCIN STEARATE
ETS
Emgel
Emu-V
Emu-Ve
Emuvin
Emycin
Endoeritrin
Erecin
Erimycin-T
Erisone
Eritomicina
Eritrocina
Eritromicina
Eritromicina [INN-Spanish]
Ermycin
Eros
Ery
Ery-B
Ery-Diolan
Ery-Sol
Ery-Tab
Ery-Tab (base)
Ery-maxin
Ery-ped
Ery-tab
Eryacne
Eryacnen
Erybid
Eryc
Eryc (TN)
Eryc 125
Eryc Sprinkles
Eryc-125
Eryc-250
Erycen
Erycette
Erycin
Erycinum
Eryderm
Erydermer
Erygel
Erygel (TN)
Eryhexal
Erymax
Erymed
Erypar
Erysafe
Erytab
Erythra-Derm
Erythra-derm
Erythro
Erythro-Statin
Erythro-Teva
Erythrocin
Erythrocin Stearate
Erythroderm
Erythrogran
Erythroguent
Erythromast 36
Erythromid
 
Erythromycin
Erythromycin & VRC3375
Erythromycin (JP15/USP/INN)
Erythromycin A
Erythromycin A, T-Stat, Pantomicina, HSDB 3074, Erytab, DRG-0279
Erythromycin B
Erythromycin Base
Erythromycin Base Base
Erythromycin Base Filmtab
Erythromycin C
Erythromycin Lactate
Erythromycin Ointment
Erythromycin Stearate
Erythromycin [INN:BAN:JAN]
Erythromycin base
Erythromycin estolate
Erythromycin ethylsuccinate
Erythromycin glucoheptonate
Erythromycin intravenous
Erythromycin lactobionate
Erythromycin oxime
Erythromycin sodium lauryl sulfate
Erythromycin, compd. with monododecyl sulfate, sodium salt
Erythromycine
Erythromycine [INN-French]
Erythromycinum
Erythromycinum [INN-Latin]
Erytop
Erytrociclin
Ethril 250
HMS1568O04
HMS1920M04
HMS2091D05
HMS500O16
HSDB 3074
I06-0245
IDI1_000294
IDI1_000397
IDI1_000702
Ilocaps
Ilosone
Ilosone (estolate)
Iloticina
Ilotycin
Ilotycin Gluceptate
Ilotycin T.S
Ilotycin T.S.
Inderm
Inderm Gel
IndermRetcin
KBio1_000294
KBio1_000397
KBio1_000702
KBio2_000555
KBio2_001139
KBio2_003123
KBio2_003707
KBio2_005691
KBio2_006275
KBioGR_001175
KBioSS_000555
KBioSS_001139
KST-1A8261
Kesso-Mycin
LMPK04000006
LS-187077
LS-64648
Latotryd
Lederpax
MLS001066618
Mephamycin
Mercina
MolPort-000-772-161
MolPort-002-507-378
MolPort-003-933-429
N-Methylerythromycin A
NCGC00179619-01
NCI-C55674
NINDS_000294
NINDS_000397
NINDS_000702
NSC 55929
NSC55929
Oftalmolosa Cusi Eritromicina
Oftamolets
PCE Dispertab (base)
Paediathrocin
Pantoderm
Pantodrin
Pantomicina
Pce
Pce (TN)
Pfizer-e
Pharyngocin
Prestwick0_000151
Prestwick1_000151
Prestwick2_000151
Prestwick3_000151
Prestwick_205
Primacine
Propiocine
Proterytrin
R-P Mycin
Retcin
Robimycin
Romycin
SBB057401
SMP1_000119
SMR000544946
SPBio_000778
SPBio_001226
SPBio_002221
SPECTRUM1500280
STK249736
Sans-acne
Sansac
Serp-AFD
Skid Gel E
Spectrum2_000759
Spectrum2_001263
Spectrum4_000538
Spectrum5_001596
Spectrum_000115
Spectrum_000659
Staticin
Staticin (TN)
Stiemicyn
Stiemycin
Sulfuric acid, monododecyl ester, sodium salt, compd. with erythromycin
T-Stat
T-stat (TN)
Taimoxin-F
Theramycin Z
Tiloryth
Tiprocin
Torlamicina
UNII-63937KV33D
Udima Ery Gel
Wemid
Wyamycin S
adecane-2,10-dione (non-preferred name)
bmse000664
erythro
erythromycin
nchembio.285-comp13
3Cyclooxygenase 2 InhibitorsPhase 4, Phase 2, Phase 3, Phase 1517
4Erythromycin EstolatePhase 485
5Erythromycin EthylsuccinatePhase 485
6Erythromycin stearatePhase 485
7
Ursodeoxycholic acidapproved, investigationalPhase 2, Phase 374128-13-231401
Synonyms:
(3a,5b,7b)-3,7-dihydroxy-cholan-24-oate
(3a,5b,7b)-3,7-dihydroxy-cholan-24-oic acid
(3a,5b,7b)-3,7-dihydroxycholan-24-oic acid
(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid
(3alpha,5beta,7beta,8xi)-3,7-dihydroxycholan-24-oic acid
(3α,5β,7β)-3,7-dihydroxycholan-24-oic acid
(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
128-13-2
17-beta-(1-Methyl-3-carboxypropyl)etiocholane-3-alpha,7-beta-diol
3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid
3,7-Dihydroxycholan-24-oic acid
3-alpha,7-beta-Dihydroxy-5-beta-cholanoic acid
3-alpha,7-beta-Dihydroxycholanic acid
3-alpha,7-beta-Dioxycholanic acid
3a,7b-Dihydroxy-5b-cholan-24-oate
3a,7b-Dihydroxy-5b-cholan-24-oic acid
3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid
3alpha,7beta-Dihydroxy-5beta-cholanic acid
4-10-00-01604 (Beilstein Handbook Reference)
50809-41-1
5beta-Cholan-24-oic acid-3alpha,7beta-diol
5beta-Cholanic Acid-3alpha,7beta-diol
7-beta-Hydroxylithocholic acid
7beta-Hydroxylithocholic acid
80225-86-1
AB00513977
AC-18919
AC-2081
AC1L1LJH
Acide ursodesoxycholique
Acide ursodesoxycholique [INN-French]
Acido ursodeossicolico
Acido ursodeossicolico [Italian]
Acido ursodeoxicolico
Acido ursodeoxicolico [INN-Spanish]
Acidum ursodeoxycholicum
Acidum ursodeoxycholicum [INN-Latin]
Actigall
Actigall (TN)
Antigall
Arsacol
BB_NC-2372
BPBio1_001052
BRN 3219888
BSPBio_000956
C07880
C24H40O4
CCRIS 5502
CHEBI:9907
CHEMBL1551
CHEMBL73390
CID11516715
CID31401
CPD-10534
CPD000058403
Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-beta)- (9CI)
Cholit-ursan
D00734
DB01586
Delursan
Deoxyursocholic Acid
Destolit
Deursil
Dom-ursodiol c
EINECS 204-879-3
HMS1570P18
ISO-URSODEOXYCHOLIC ACID
 
IU5
LMST04010033
LS-53033
Litursol
Lyeton
MLS000028461
MLS001066373
MolPort-001-794-630
MolPort-005-932-884
NCGC00179363-01
NCI60_028904
NSC 657950
NSC 683769
PHL-ursodiol c
PMS-ursodiol c
Peptarom
Prestwick0_000958
Prestwick1_000958
Prestwick2_000958
Prestwick3_000958
S1643_Selleck
SAM002264653
SMP2_000012
SMR000058403
SPBio_003105
Sodium Ursodeoxycholate
Solutrat
U-9000
U0030
U5127_SIGMA
UDCA
UDCS
UNII-724L30Y2QR
URSODEOXYCHOLIC ACID
UrSO
Urosdesoxycholate
Urosdesoxycholic acid
Urosiol
Ursacholic Acid
Ursacol
Urso
Urso (TN)
Urso 250
Urso DS
Urso Forte
Ursobilin
Ursochol
Ursodamor
Ursodeoxy cholic acid
Ursodeoxycholate
Ursodeoxycholic acid
Ursodeoxycholic acid (JP15/INN)
Ursodeoxycholic acid, UDCA, Ursosan, Ursofalk, Urso Forte, Udiliv, Ursodiol
Ursodeoxycholicacid
Ursodesoxycholic acid
Ursodexycholate
Ursodexycholic Acid
Ursodexycholic acid
Ursodiol
Ursodiol (USP)
Ursodiol Tablets, 250 mg
Ursodiol Tablets, 500 mg
Ursodiol [USAN]
Ursofalk
Ursolvan
Ursosan
chenodeoxycholic acid
ursodeoxycholate
ursodiol
8
SulindacapprovedPhase 3, Phase 23538194-50-25352, 1548887
Synonyms:
(E)-(1)-5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid
(Z)-5-Fluoro-2-methyl-1-((P-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
(Z)-5-Fluoro-2-methyl-1-[[4-(methyl-sulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
(Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid
2-[(3E)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid
2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid
2-[6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid
32004-68-5
38194-50-2
5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid
53933-60-1
6301-55-9
9000-14-0
AB00513800
AC-4550
AC1L1K5T
AC1LU7GU
AC1LU7GY
AC1Q6YHK
AKOS004119989
AR-1A9609
Aclin
Aflodac
Alphapharm Brand of Sulindac
Apo Sulin
Apo-Sulin
Apotex Brand of Sulindac
Arthrobid
Arthrocine
BB_SC-1128
BPBio1_000315
BRD-A03427350-001-01-3
BRD-A13946108-001-04-9
BRN 2951842
BSPBio_000285
BSPBio_002890
C01531
C20H17FO3S
CAS-38194-50-2
CCRIS 3305
CHEBI:9352
CHEMBL1376
CID1548885
CID1548887
CID5352
CPD000326718
Cahill May Roberts Brand of Sulindac
Chemia Brand of Sulindac
Chibret
Clinoril
Clinoril (TN)
Copal
Copal resin
Copal rosin varnish
Copals
D00120
D013467
DB00605
DivK1c_000601
EINECS 232-527-9
EINECS 250-893-8
EINECS 253-819-2
EINECS 258-873-0
EU-0101070
Gum copal
HMS1568O07
HMS1921C11
HMS2089J04
HMS2092K15
HMS501O03
I06-0523
IDI1_000601
KBio1_000601
KBio2_001506
KBio2_002320
KBio2_004074
KBio2_004888
KBio2_006642
KBio2_007456
KBio3_002110
KBio3_002800
KBioGR_001571
 
KBioGR_002320
KBioSS_001506
KBioSS_002322
KST-1B6530
Kenalin
Kendrick Brand of Sulindac
Klinoril
LS-81610
Lopac-S-8139
Lopac0_001070
MK 231
MK-231
MK231
MLS001056554
MLS001304027
MLS002207124
Merck Brand of Sulindac
Merck Sharp & Dohme Brand of Sulindac
Mobilin
MolPort-002-507-760
MolPort-003-666-287
NCGC00015970-01
NCGC00015970-02
NCGC00015970-03
NCGC00015970-08
NCGC00025268-01
NCGC00025268-02
NCGC00025268-03
NCGC00094349-01
NCGC00094349-02
NINDS_000601
Novo Sundac
Novo-Sundac
Novopharm Brand of Sulindac
Nu Pharm Brand of Sulindac
Nu Sulindac
Nu-Pharm Brand of Sulindac
Nu-Sulindac
Prestwick0_000073
Prestwick1_000073
Prestwick2_000073
Prestwick3_000073
Prestwick_456
Resin copal
S 8139
S2007_Selleck
S4429_SIAL
S8139_SIAL
S8139_SIGMA
SAM002554933
SBB058181
SMR000043852
SMR000326718
SPBio_001451
SPBio_002206
SPECTRUM1500556
STK802068
Spectrum2_001326
Spectrum3_001365
Spectrum4_000876
Spectrum5_001024
Spectrum_001026
Sulindac
Sulindac (JAN/USP/INN)
Sulindac [USAN:BAN:INN:JAN]
Sulindac sulfoxide
Sulindaco
Sulindaco [INN-Spanish]
Sulindacum
Sulindacum [INN-Latin]
Sulindal
Tocris-1707
UNII-184SNS8VUH
UNII-M5221THD3M
UNM-0000306136
Z-5-Fluoro-2-methyl-1-[p-(methlsulfinyl)benzylidene]indene-3-acetic acid
[(1E)-5-fluoro-2-methyl-1-{[4-(methylsulfinyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid
cMAP_000021
cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
cis-5-Fluoro-2-methyl-1-((P-methylsulfinyl)benzylidene)indene-3-acetic acid
cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid
sulindac
{(1E)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
{(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
{5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1h-inden-3-yl}acetic acid
9
LoperamideapprovedPhase 310453179-11-63955
Synonyms:
2-methoxyethyl1-methylethyl2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
34552-83-5 (mono-hydrochloride)
4-(4-Chlorophenyl)-N,N-dimethyl-.alpha.,.alpha.-diphenyl-4-hydroxy-1-piperidinebutanamide
4-(4-Chlorophenyl)-N,N-dimethyl-alpha,alpha-diphenyl-4-hydroxy-1-piperidinebutanamide
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
5-21-02-00379 (Beilstein Handbook Reference)
53179-11-6
AB00053697
AC1L1H38
AKOS000573892
Apo-Loperamide
BAS 01889668
BPBio1_000274
BRD-K61250553-001-02-9
BRD-K61250553-003-05-8
BRN 1558273
BSPBio_000248
BSPBio_001381
BSPBio_002769
Bio1_000082
Bio1_000571
Bio1_001060
Bio2_000101
Bio2_000581
C07080
C29H33ClN2O2
CAS-34552-83-5
CBiol_001796
CHEBI:162259
CHEBI:6532
CHEMBL841
CID3955
D08144
DB00836
Diamide (TN)
Diarr-Eze
DivK1c_000215
EINECS 258-416-5
HMS1791F03
HMS1989F03
HMS2089C13
IDI1_000215
IDI1_033851
Imodium A-D
Imodium A-D Caplets
Ioperamide
KBio1_000215
KBio2_000101
KBio2_000854
KBio2_002669
KBio2_003422
KBio2_005237
KBio2_005990
KBio3_000201
KBio3_000202
 
KBio3_001989
KBioGR_000101
KBioGR_001685
KBioSS_000101
KBioSS_000854
Kaopectate II
L000709
LS-114352
Lopac-L-4762
Lopac0_000708
Loperacap
Loperamid
Loperamida
Loperamida [INN-Spanish]
Loperamide
Loperamide (INN)
Loperamide Hydrochloride
Loperamide Monohydrochloride
Loperamide [INN:BAN]
Loperamide hydrochloride
Loperamidum
Loperamidum [INN-Latin]
Lopéramide
Maalox Anti-Diarrheal
MolPort-001-969-016
NCGC00015608-01
NCGC00015608-08
NCGC00016828-01
NCGC00024818-01
NCGC00024818-02
NCGC00024818-03
NCGC00024818-04
NCGC00024818-05
NINDS_000215
Nu-Loperamide
Oprea1_109220
PMS-Loperamide
Pepto Diarrhea Control
Prestwick0_000144
Prestwick1_000144
Prestwick2_000144
Prestwick3_000144
R-18553
Rho-Loperamide
SPBio_001816
SPBio_002187
ST095179
Spectrum2_001738
Spectrum3_001015
Spectrum4_001143
Spectrum5_001374
Spectrum_000374
Tocris-0840
UNII-6X9OC3H4II
loperamide
nchembio.559-comp8
nchembio.79-comp7
10AntidiarrhealsPhase 3104
11
EflornithinePhase 3, Phase 23270052-12-93009
Synonyms:
.alpha.-DFMO HCl
2,5-diamino-2-(difluoromethyl)pentanoic acid
2,5-diamino-2-(difluoromethyl)pentanoic acid hydrate hydrochloride
2,5-diamino-2-(difluoromethyl)pentanoic acid hydrochloride
2-(Difluoromethyl)-DL-ornithine
2-(Difluoromethyl)-DL-ornithine HCl
2-(Difluoromethyl)-DL-ornithine hydrochloride
2-(Difluoromethyl)-DL-ornithine monohydrochloride
2-(Difluoromethyl)-DL-ornithine monohydrochloride, monohydrate
2-(Difluoromethyl)-DL-ornithine monohydrochloride.monohydrate
2-(Difluoromethyl)ornithine
2-(Difluoromethyl)ornithine hydrochloride hydrate
67037-37-0
68278-23-9
70050-56-5
70052-12-9
70052-12-9 (Parent)
96020-91-6
96020-91-6 (mono-hydrochloride, monohydrate)
AC-388
AC-5497
AC1L1EYW
AC1L1M41
AC1L9B1G
BMS 203522
BRN 2250529
C07997
C6H12F2N2O2.HCl.H2O
CCRIS 3295
CCRIS 3718
CCRIS 5805
CHEBI:41948
CHEMBL1201037
CHEMBL536971
CID3009
CID441361
CID57004
CPP-1X
D,L-alpha-Difluoromethylornithine
D,L-alpha-Difluoromethylornithine hydrochloride
D00829
D07883
D193_SIGMA
DFMO (growth regulator)
DFMO HCl
DFMO hydrochloride
DFMO hydrochloride hydrate
DL-.alpha.-Difluoromethylornithine
DL-Ornithine, 2-(difluoromethyl)-, monohydrochloride
DL-Ornithine, 2-(difluoromethyl)-, monohydrochloride, monohydrate
DL-alpha-(Difluoromethyl)ornithine
DL-alpha-Difluoromethylornithine
DL-alpha-Difluoromethylornithine hydrochloride
DL-alpha-Difluoromethylornithine hydrochloride hydrate
 
DL-alpha-Difluoromethylornithine, Hydrochloride
Difluoromethylornithine
Difluromethylornithine
EFLORNITHINE
EFLORNITHINE HYDROCHLORIDE
EINECS 269-532-0
EU-0100429
Eflornithine (INN)
Eflornithine HCl
Eflornithine [INN:BAN]
Eflornithine hydrochloride (USAN)
Eflornithine hydrochloride [USAN]
Eflornithine hydrochloride hydrate
Eflornithine hydrochloride monohydrate
Eflornithinum
Eflornithinum [Latin]
Eflornitina
Eflornitina [Spanish]
FT-0082608
FT-0082826
HSCI1_000267
I06-0316
I06-0530
LS-178282
LS-185084
LS-7332
LS-98405
Lopac0_000429
MDL 71,782 A
MDL 71782
MDL-71782A
MLS000069341
MLS001332583
MolPort-003-940-991
N-Difluoromethylornithine
NCGC00015316-03
NCGC00093850-01
NCGC00162152-01
NSC270295
NSC337250
Ornidyl
Ornidyl (TN)
Ornithine, 2-(difluoromethyl)-, monohydrochloride
RMI 71782
RMI-71782
SBB066102
SMR000058442
UNII-4NH22NDW9H
UNII-ZQN1G5V6SR
Vaniqa
alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid
alpha-(Difluoromethyl)-DL-ornithine
alpha-Difluoromethylornithine
alpha-Difluoromethylornithine hydrochloride
dfmo
12Omega 3 Fatty AcidNutraceuticalPhase 2, Phase 3890
13ColaNutraceuticalPhase 2, Phase 3, Phase 11690
14
Sirolimusapproved, investigationalPhase 1, Phase 2174253123-88-95284616, 6436030, 46835353
Synonyms:
(-)-Rapamycin
(-)-rapamycin
1fkb
1pbk
23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine
23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29
3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
53123-88-9
A422989, NSC226080
AC-722
AC1L1JH9
AC1L7MJ9
AC1L9ZMV
AY 22989
AY-22989
AY22989
Ambotz53123-88-9
Antibiotic AY 22989
BIDD:PXR0165
Bio1_000293
Bio1_000782
Bio1_001271
Bio2_000375
Bio2_000855
BiomolKI2_000084
C07909
C51H79NO13
CBiol_002007
CCRIS 9024
CHEBI:100923
CHEBI:9168
CHEMBL413
CID10213190
CID10795871
CID11949238
CID11959112
CID313006
CID478951
CID5040
CID5284616
CID5358081
CID5374464
CID5460439
CID5497196
CID5924240
CID6436030
CID6610270
CID6610346
CID6711160
CID6713081
CID9833581
CID9854379
CID9854380
CID9962926
CID9962928
D00753
DB00877
DE-109
DivK1c_006936
 
FT-0082351
HMS2089A21
HSDB 7284
KBio1_001880
KBio2_000410
KBio2_002978
KBio2_005546
KBio3_000779
KBio3_000780
KBioGR_000410
KBioSS_000410
LCP-Siro
LMPK06000003
LS-143290
MLS000028373
MS-R001
MolMap_000043
MolPort-003-959-433
NCGC00021305-05
NCI60_001851
NCIMech_000355
NSC 226080
NSC226080
Perceiva
QTL1_000069
R0395_SIAL
R0395_SIGMA
RAP
RAPA
RPM
Rapammune
Rapamune
Rapamune (TN)
Rapamycin
Rapamycin (TN)
Rapamycin C-7, analog 4
Rapamycin Immunosuppressant Drug
Rapamycin from Streptomyces hygroscopicus
S1039_Selleck
SIIA 9268A
SILA 9268A
SILA9268A
SMP1_000255
SMR000058564
Sirolimus
Sirolimus (RAPAMUNE)
Sirolimus (USAN/INN)
Sirolimus [USAN:BAN:INN]
Sirolimus, Rapamune,Rapamycin
SpecPlus_000840
UNII-W36ZG6FT64
UNM-0000358684
WY-090217
Wy 090217
heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy
nchembio.100-comp4
nchembio.2007.42-comp2
nchembio.79-comp1
nchembio762-comp1
nchembio883-comp3
rapamycin
sirolimus
15
Miconazoleapproved, investigationalPhase 1, Phase 2291222916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
Desenex
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Makesense
Micantin (nitrate)
Micatin
 
Miconasil Nitrate
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Oravig
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
Rash Relief Antifungal
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
16
EverolimusapprovedPhase 1, Phase 21742159351-69-66442177
Synonyms:
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
(1R,9S,12S,15R,16E,23S,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriacont
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34as)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethy
07741_FLUKA
159351-69-6
40-O-(2-hydroxyethyl)-rapamycin
42-O-(2-Hydroxyethyl)rapamycin
Afinitor
Afinitor Disperz
CERTICAN(R)
CHEMBL1201755
Certican
D02714
DB01590
 
Everolimus
Everolimus (JAN/USAN/INN)
Everolimus [USAN]
LS-143292
MolPort-003-847-342
MolPort-003-925-588
NCGC00167512-01
NVP-RAD-001
RAD 001
RAD-001
RAD-001C
RAD001
RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus
S1120_Selleck
SDZ-RAD
UNII-9HW64Q8G6G
VOTUBIA
Zortress
everolimus
17
MetforminapprovedPhase 21573657-24-9, 1115-70-414219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMBG
DMGG
Diabefagos
Diabetosan
Diabex
Diaformin
Dianben
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Meguan
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin Hydrochloride
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
Obimet
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
18
Erlotinibapproved, investigationalPhase 2759183321-74-6176870, 176871
Synonyms:
183321-74-6
4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline
774
AB1004620
AC-399
AC1L42EI
AKOS000282911
AQ4
BCB03_000783
C400278
CHEBI:114785
CHEMBL553
CID176870
CP 358,774
CP-258
CP-358,774
CP-358774
DB00530
EN002711
Erlotinib
Erlotinib Base
Erlotinib Hydrochloride
Erlotinib(Tarceva)
Erlotinib, OS-774
 
Erlotinin
FT-0083688
HMS2089F05
I01-1241
K00241
Kinome_3317
LS-184395
MolPort-003-847-084
N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine
N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
NCGC00164574-01
NSC 718781
OSI 744
OSI-774
R 1415
SR-05000001460
SR-05000001460-2
STK623143
Tarceva
UNII-J4T82NDH7E
ZINC01546066
[6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE
[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine
erlotinib
n-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine
nchembio866-comp3
19
Inulinapproved, nutraceuticalPhase 2849005-80-524763
Synonyms:
(2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-2-[[(2R,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxymethy
189444-25-5
887747-94-6
AC1L2NNM
AI3-19506
CID24763
DB00638
 
EINECS 232-684-3
INULIN
Inulin USP 27
Inulin [BAN]
Inulin and sodium chloride
Inulin from Jerusalem artichokes
LS-186416
LS-187349
20
Vitamin Aapproved, nutraceuticalPhase 238611103-57-4, 68-26-8445354
Synonyms:
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
(2e,4e,6e,8e)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
.alpha.lin
.alpha.sterol
.beta.-Retinol
11103-57-4
13123-33-6
1341-18-0
1406-67-3
17104-91-5
1rbp
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclchexen-1-yl)-2,4,6,8-nonatetraen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonate-traen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraen-1-ol
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer
4-06-00-04133 (Beilstein Handbook Reference)
53637-36-8
5979-23-7
68-26-8
95144_FLUKA
95144_SIGMA
95146_FLUKA
95146_SIGMA
A-Mulsal
A-Sol
A-Vi-Pel
A-Vitan
AC-11701
AC1L9HU3
AC1Q7BU9
ACON
ALL-TRANS RETINOL (SEE ALSO RETINOID PROJECT 1)
AR-1L3057
ATAV
Afaxin
Agiolan
Agoncal
Alcohol 9,13-dimethyl-7-(1,1,5-trimethyl-6-cyclohexen-5-yl)-7,9,11,13-nonatetraen-15-ol
Alcovit A
All Trans Retinol
All-trans retinol
All-trans-Retinol
Alphalin
Alphasterol
Anatola
Anatola A
Anti-infective vitamin
Antixerophthalmic vitamin
Antixerophthalmisches Vitamin
Aoral
Apexol
Apostavit
Aquasol A
Aquasol A Parenteral
Aquasynth
Atars
Avibon
Avita
Avitol
Axerol
Axerophthol
Axerophtholum
BIDD:PXR0102
BRN 0403040
Bentavit A
Biosterol
C00473
C17276
C20H30O
CCRIS 5444
CHEBI:17336
CHEMBL986
CID445354
Chocola A
Chocola a
Cylasphere
D014801
D06543
DB00162
Del-VI-A
Disatabs Tabs
Dofsol
Dohyfral A
EINECS 200-683-7
EINECS 234-328-2
Epiteliol
HMS1921B04
HMS2092L13
HMS501I08
HSDB 815
Hi-A-Vita
Homagenets Aoral
Homagenets aorl
Hydrovit A
IDI1_000486
LMPR01090001
LPK
LS-1578
Lard Factor
M.V.C. 9+3
M.V.I.-12
 
MLS001066379
MLS001074751
MolPort-001-785-962
Mvc Plus
Myvpack
NCGC00091784-01
NCGC00091784-02
NCGC00091784-03
NCGC00091784-04
NCGC00091784-05
NCGC00091784-06
NSC 122759
NSC122759
Nio-A-Let
Oleovitamin A
Ophthalamin
Plivit A
Prepalin
R7632_SIGMA
Retin-11,12-t2-ol (9CI)
Retinol
Retinol [INN:BAN]
Retinol solution
Retinol, all-trans- (8CI)
Retinol-(cellular-retinol-binding-protein)
Retinolo
Retinolo [DCIT]
Retinolum
Retinolum [INN-Latin]
Retrovitamin A
Ro-a-vit
Rovimix A 500
SDCCGMLS-0066724.P001
SMP2_000102
SMR000112036
SPECTRUM1501203
ST057232
Sehkraft A
Solu-A
Spectrum5_000993
Spectrum5_001997
Super A
Testavol
Testavol S
Thalasphere
UNII-81G40H8B0T
UNII-G2SH0XKK91
Vaflol
Vafol
Veroftal
Vi-.alpha.
Vi-Alpha
Vi-Dom-A
Vi-a
Vio-A
Vitamin A
Vitamin A (Feed)
Vitamin A (USP)
Vitamin A alcohol
Vitamin A alcohol (VAN)
Vitamin A cryst
Vitamin A palmitate
Vitamin A1
Vitamin A1 alcohol
Vitamin A1 alcohol, all trans
Vitamin a
Vitamin- A
Vitamin- A alcohol
Vitamin- A alcohol solution
Vitamin- A1
Vitamin-?A
Vitamin-?A alcohol
Vitamin-?A alcohol solution
Vitamin-?A1
Vitamine A
Vitaminum A
Vitavel A
Vitavel-A
Vitpex
Vogan
Vogan-Neu
Vogan-nu
WLN: L6UTJ A1 B1U1Y1&U2U1Y1&U2Q C1 C1
Wachstumsvitamin
ZINC03831417
Zinosan N
[11,12-3H]-Retinol
alin
all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
all-trans-Retinol
all-trans-Retinyl alcohol
all-trans-Vitamin A
all-trans-Vitamin A alcohol
all-trans-Vitamin A1
all-trans-retinol
all-trans-retinyl alcohol
all-trans-vitamin A alcohol
b-Retinol
beta-Retinol
retinol
tROL
trans-Retinol
trans-Retinol acid (Vitamin A)
trans-Vitamin A alcohol
trans-retinol
21
CurcuminPhase 2120458-37-7969516
Synonyms:
1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione
C.I. Natural Yellow 3
CI Natural Yellow 3
Cucurmin
Curcuma
Curcumin
Curcumin I
Diferaloylmethane
Diferuloylmethane
Gelbwurz
Golden seal
Haidr
Halad
Haldar
Halud
Hydrastis
 
Indian saffron
Indian turmeric
Kacha haldi
Kurkumin [czech]
Merita earth
Natural yellow 3
Orange root
Safran D'inde
Souchet
Terra merita
Tumeric yellow
Turmeric
Turmeric (>98% curcurmin)
Turmeric oleoresin (79%-85% curcumin)
Turmeric yellow
Yellow ginger
Yellow puccoon
Yellow root
Yo-kin
Zlut prirodni 3 [Czech]
22Retinol palmitatePhase 2386
23retinolNutraceuticalPhase 2386
24
AspirinapprovedPhase 197150-78-22244
Synonyms:
11126-35-5
11126-37-7
1oxr
2-(ACETYLOXY)benzoic acid
2-(Acetyloxy)benzoate
2-(Acetyloxy)benzoic acid
2-Acetoxybenzenecarboxylic acid
2-Acetoxybenzoate
2-Acetoxybenzoic acid
2-Carboxyphenyl acetate
2349-94-2
26914-13-6
50-78-2
7 Select Adult Chewable Aspirin
7 Select Aspirin
8-hour Bayer
98201-60-6
A 5376
A.S.A
A.S.A.
A.S.A. Empirin
A.S.A. empirin
A2093_SIGMA
A3160_SIGMA
A5376_SIGMA
A6810_SIGMA
AB1003266
AC 5230
AC1L1D8U
AC1Q1LA0
ACETYLSALICYLIC ACID
AI3-02956
AIN
AKOS000118884
ASA
Acenterine
Acesal
Acetal
Acetard
Aceticyl
Acetilsalicilico
Acetilum acidulatum
Acetisal
Acetol
Acetonyl
Acetophen
Acetosal
Acetosalic acid
Acetosalin
Acetoxybenzoic acid
Acetylin
Acetylsal
Acetylsalicylate
Acetylsalicylic acid
Acetylsalicylsaeure
Acetylsalicylsaure
Acetylsalycilic acid
Acetyonyl
Acetysal
Acetysalicylic acid
Acide 2-(acetyloxy)benzoique
Acide acetylsalicylique
Acide acétylsalicylique
Acido O-acetil-benzoico
Acido acetilsalicilico
Acidum acetylsalicylicum
Acimetten
Acisal
Acylpyrin
Adiro
Adult Chewable Low Dose Aspirin
Adult Low Dose Aspirin
Adult Low Dose Aspirin Enteric Safety Coated
Adult Low Dose Enteric Coated Aspirin
Adult Low Strength Aspirin
Aloxiprimum
Asacard
Asagran
Asaphen
Asatard
Ascoden-30
Ascriptin Maximum Strength Buffered Aspirin
Ascriptin Regular Strength Buffered Aspirin
Aspalon
Aspec
Aspergum
Aspi-cor
Aspir Low
Aspir-Mox
Aspirdrops
Aspirin
Aspirin (JP15/USP)
Aspirin 81 Mg
Aspirin 81 Mg Low Dose
Aspirin Adult Low Dose
Aspirin Adult Low Strength
Aspirin Adult Low Strength Aspirin
Aspirin Adult low strength
Aspirin Chewable Low Dose
Aspirin Delayed Release
Aspirin EC
Aspirin EXTRA STRENGTH
Aspirin Ec
Aspirin Enteric
Aspirin Enteric Coated
Aspirin Enteric Coated Low Dose
Aspirin Enteric Safety Coated
Aspirin Enteric Safety-Coated
Aspirin Low Dose
Aspirin Low Dose Chewable
Aspirin Low Dose Enteric Coated
Aspirin Low Dose Safety Coated
Aspirin Low Strength
Aspirin Nsaid
Aspirin Regular Strength
Aspirin Regular Strength regular strength
Aspirin Regular strength
Aspirin Safety Coated
Aspirin Safety Coated Adult Low Dose
Aspirin Safety coated
Aspirin Thin coated
Aspirin [BAN:JAN]
Aspirin adult low dose
Aspirin adult low strength
Aspirin enteric safety coated
Aspirin low dose
Aspirin low dose chewable
Aspirin low dose enteric coated
Aspirin regular strength
Aspirina 03
Aspirine
Aspiring
Asprin
Aspro
Aspro Clear
Asteric
Azetylsalizylsaeure
Azetylsalizylsäure
BIDD:GT0118
BRN 0779271
Bay-e-4465
Bayer
Bayer Advanced Aspirin Extra Strength
Bayer Advanced Aspirin Regular Strength
Bayer Aspirin 8 Hour
Bayer Aspirin Regimen Chewable Low Dose Aspirin Orange
Bayer Aspirin Regimen Regular Strength
Bayer Buffered
Bayer Chewable - Aspirin Regimen Low Dose Aspirin Cherry Flavored
Bayer Extra Strength Aspirin For Migraine Pain
Bayer Fast Release
Bayer Genuine Aspirin
Bayer Low Dose
Bayer Plus
Bayer Plus Extra Strength
Bayer Womens
Benaspir
Bi-prin
Bialpirina
Bialpirinia
Buffered Aspirin
Bufferin
Bufferin LOW DOSE BUFFERED ASPIRIN
C01405
CCRIS 3243
CHEBI:15365
CHEMBL25
CID2244
Caprin
Cardioaspirin
Cardioaspirina
Care One Aspirin
Cemirit
Chewable Adult Low Dose Aspirin
Chewable Aspirin
Chewable Low Dose Aspirin
Claradin
Clariprin
Colfarit
Contrheuma retard
Coricidin
Critical Care Aspirin To Go
Crystar
D00109
D001241
DB00945
Decaten
Delgesic
Dg Health Aspirin
Direct Safety Aspirin
Dispril
DivK1c_000555
Dolean pH 8
Duramax
ECM
EINECS 200-064-1
EU-0100038
Easprin
Easprin (TN)
Ec-81aspirin Enteric Coated
Ecolen
Ecotrin
Ecotrin Regular Strength
Empirin
Empirin with Codeine
Endosprin
Endydol
Enteric Aspirin
Enteric Coated Aspirin
Enteric Coated Aspirin Regular Strength
Enteric Coated Aspirin Regular strength
Enteric Coated Aspirin regular strength
Enteric Coated Asprin 81 Mg
Enteric Coated Low Dose Aspirin
 
Enteric Safety Coated Aspirin
Entericin
Enterophen
Enterosarein
Enterosarine
Entrophen
Equaline Aspirin
Equaline Aspirin adult low dose
Equate Aspirin
Equate Aspirin chewable
Extren
Fasprin
Flanax Aspirin Pain Reliever
Formucare Aspirin
Genuine Aspirin
Globentyl
Globoid
Good Neighbor Pharmacy Aspirin
Good Neighbor Pharmacy Aspirin Enteric Safety Coated
Good Neighbor Pharmacy Aspirin orange flavor chewable
Good Sense Aspirin
Good Sense Aspirin Enteric Safety Coated
HMS1920E13
HMS2090G03
HMS2091K13
HMS501L17
HSDB 652
Handy Solutions Genuine Aspirin Bayer
Health Mart Aspirin
Health Mart Regular Strength Enteric Coated Aspirin
Health Sense Adult Chewable Low Strength Aspirin
Health Sense Aspirin 81
Health Sense Ecpirin
Healthy Accents Aspirin
Helicon
Henry Schein Aspirin
I14-7505
IDI1_000555
Idragin
Istopirin
KBio1_000555
KBio2_001725
KBio2_002271
KBio2_004293
KBio2_004839
KBio2_006861
KBio2_007407
KBio3_002149
KBio3_002751
KBioGR_000398
KBioGR_002271
KBioSS_001725
KBioSS_002272
Kapsazal
Kroger Value Aspirin
Kyselina 2-acetoxybenzoova
Kyselina acetylsalicylova
LS-143
Leader Aspirin
Leader Cardinal Health Aspirin
Leader Low Dose Aspirin
Levius
Lopac-A-5376
Lopac0_000038
Low Dose Adult Aspirin
Low Dose Aspirin
Low Dose Aspirin 81 Mg Safety Coated
Low Dose Aspirin Enteric Safety Coated
Low Dose Asprin
Low Dose Chewable Aspirin
Low Dose Miniprin Enteric Safety Coated
Low Dose Pain Relief Aspirin
Low Strength Chewable Aspirin
Low-dose Aspirin
MLS001055329
MLS001066332
MLS001336045
MLS001336046
Magnecyl
Measurin
Medi First Plus Aspirin
Medi-first Aspirin
Medique Aspirin
Medisyl
Micristin
Micro-coated Aspirin
Miniprin
MolPort-000-871-622
NCGC00015067-01
NCGC00015067-04
NCGC00015067-09
NCGC00090977-01
NCGC00090977-02
NCGC00090977-03
NCGC00090977-04
NCGC00090977-05
NCGC00090977-06
NCGC00090977-07
NCI60_002222
NINDS_000555
NSC 27223
NSC27223
NSC406186
Neuronika
North Aspirin
Novasen
Novid
Nu-seals
Nu-seals aspirin
O-(Acetyloxy)benzoate
O-(Acetyloxy)benzoic acid
O-Acetoxybenzoate
O-Acetoxybenzoic acid
O-Acetylsalicylic acid
O-Carboxyphenyl acetate
O-accetylsalicylic acid
O-acetylsalicylic acid
PL-2200
Pain Relief Aspirin
Pain Relief Aspirin Low Dose
Persistin
Pharbest Aspirin 325mg
Pharbest Regular Strength Aspirin
Pharmacin
Pirseal
Plus Pharma NSAID 325 mg
Plus Pharma Nsaid Aspirin
Polopirin
Polopiryna
Premaspin
R16CO5Y76E [UNII]
Rapid Comfort Aspirin
Regular Strength Aspirin
Regular Strength Aspirin Ec
Regular Strength Buffered Aspirin
Regular Strength Enteric Aspirin
Regular Strength Enteric Coated Aspirin
Regular Strength Pain Relief
Regular Strength Tri-buffered Aspirin
Rexall Aspirin
Rheumin tabletten
Rheumintabletten
Rhodine
Rhonal
Ronal
Rugby Aspirin
Rx Act Aspirin
S-211
SMR000059138
SP 189
SPBio_001838
SPECTRUM1500130
ST075414
Safety Coated Aspirin
Safety Coated Enteric Aspirin
Salacetin
Salcetogen
Saletin
Salicylic acid acetate
Salicylic acid, acetate
Salospir
Smart Health Aspirin regular strength
Smart Sense Aspirin
Solfrin
Solprin
Solprin acid
Solpyron
Solupsan
Solves - Aspirin Cherry
Spectrum2_001899
Spectrum3_001295
Spectrum4_000099
Spectrum5_000740
Spectrum_001245
Spira-Dine
St. Joseph
St. Joseph Aspirin for Adults
St. Joseph Chewable Aspirin
St. Joseph Safety Coated Aspirin
Sunmark Aspirin
Sunmark Aspirin Regular Strength
Sunmark Aspirin adult low strength
Sunmark Aspirin low dose
Supac
Tasprin
Temperal
Toldex
Topcare Aspirin
Tri-buffered Aspirin
Triaminicin
Triple-sal
UNII R16CO5Y76E
UNII-R16CO5Y76E
UNII=R16CO5Y76E
UNM-0000306102
Uncoated Aspirin
Value Pharma Aspirin Pain Reliever
Value Pharmapain Reliever Extra Strength
Vanquish
WLN: QVR BOV1
XAXA
Xaxa
Yasta
ZORprin
Zee Aspirin
aspirin
cMAP_000006
component of Midol
component of Synirin
nchem.859-comp6
o-Acetoxybenzoic acid
o-Carboxyphenyl acetate
o-acetoxybenzoic acid
o-carboxyphenyl acetate
ácido acetilsalicílico
25
Bevacizumabapproved, investigationalPhase 11820216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
26RaspberryNutraceuticalPhase 125
27Turmeric extract53
28Fluorides327
29TurmericNutraceutical60

Interventional clinical trials:

(show top 50)    (show all 56)
idNameStatusNCT IDPhase
1Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous PolyposisRecruitingNCT02175914Phase 4
2Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted VersionNot yet recruitingNCT02354560Phase 4
3Observational Familial Adenomatous Polyposis Registry Study In Patients Receiving Celecoxib Compared to Control PatientsTerminatedNCT00151476Phase 4
4A Study of Rofecoxib in Familial Adenomatous Polyposis (FAP)TerminatedNCT00140894Phase 4
5Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous PolyposisCompletedNCT00808743Phase 2, Phase 3
6Chemoprevention Trial in Familial Adenomatous Polyposis (FAP) Coli Using EPACompletedNCT00510692Phase 2, Phase 3
7Celecoxib to Prevent Colorectal Cancer in Patients Who Have Undergone Surgery to Remove PolypsCompletedNCT00005094Phase 3
8Clinical Approaches to Ileal Pouch DysfunctionCompletedNCT00293553Phase 3
9Trial of Eflornithine Plus Sulindac in Patients With Familial Adenomatous Polyposis (FAP)RecruitingNCT01483144Phase 3
10Use of Post Operative Loperamide in Colorectal Patients After Diverting IleostomiesRecruitingNCT02263365Phase 3
11Ursodeoxycholic Acid in the Treatment of Duodenal Adenomas in Familial Adenomatous Polyposis (FAP) PatientsActive, not recruitingNCT00134758Phase 2, Phase 3
12Trial In Pediatric Patients With Familial Adenomatous Polyposis (FAP)TerminatedNCT00585312Phase 3
13Coxib-inhibition of Duodenal Polyp Growth in FAPTerminatedNCT00844727Phase 2, Phase 3
14A Trial of Low Dose Sulindac Combined With Eflornithine in Patients With Familial Adenomatous Polyposis (FAP)WithdrawnNCT01245816Phase 3
15Exisulind in Preventing Polyps in Patients With Familial Adenomatous PolyposisWithdrawnNCT00026468Phase 2, Phase 3
16The Chemopreventive Effect of Metformin in Patients With Familial Adenomatous Polyposis: Double Blinded Randomized Controlled StudyRecruitingNCT01725490Phase 2
17Influence of Sulindac and Probiotics on the Development of Pouch Adenomas in Patients With Familial Adenomatous PolyposisRecruitingNCT00319007Phase 2
18A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type FibromatosisRecruitingNCT01265030Phase 1, Phase 2
19A Clinical Trial of COX and EGFR Inhibition in Familial Polyposis PatientsActive, not recruitingNCT01187901Phase 2
20Molecular Targeting of 15-Lipoxygenase-1 (15-LOX-1) for Apoptosis Induction in Human Colorectal CancersActive, not recruitingNCT00503035Phase 2
21Celecoxib With or Without Eflornithine in Preventing Colorectal Cancer in Patients With Familial Adenomatous PolyposisTerminatedNCT00033371Phase 2
22Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis PatientsWithdrawnNCT00248053Phase 2
23Molecular Fluorescence Endoscopy in Patients With Familial Adenomatous Polyposis, Using Bevacizumab-IRDye800CWCompletedNCT02113202Phase 1
24Lyophilized Black Raspberries in Adults With Familial Adenomatous Polyposis (FAP)CompletedNCT00770991Phase 1
25Celecoxib in Preventing Colorectal Cancer in Young Patients With a Genetic Predisposition for Familial Adenomatous PolyposisCompletedNCT00685568Phase 1
26Study of Biochemical Markers to Determine the Acetylsalicylic Acid Chemopreventive Effect Through Antiplatelet ActionCompletedNCT02060396Phase 1
27A Pilot Open-Label Crossover Bioavailability Study of Celecoxib in Healthy VolunteersCompletedNCT00813241Phase 1
28Is Diverting Ileostomy Necessary in Stapled Ileoanal Pouch?CompletedNCT01173250
29Single Incision Laparoscopic Surgery in Treating Patients With Colorectal DiseaseCompletedNCT01656746
30Dual Focus NBI and pCLE in FAP Related Duodenal AdenomaCompletedNCT02162173
31A Cohort Study of Patients Treated With Brachytherapy for Selected Desmoid Patients in Gardner SyndromeCompletedNCT01286662
32Endoscopic Papillectomy for Early Ampullary Tumors: Long-term Results of the First Large Multicenter Prospective StudyCompletedNCT01764503
33Genetic Analysis of Hereditary Prostate CancerCompletedNCT00001469
34Oligogenic Determinism of Colorectal CancerCompletedNCT01057953
35Registry With Information About Colitis Ulcerosa and Familial Adenomatous Polyposis PatientsRecruitingNCT01604564
36Small Bowel Endoscopic Evaluation in Familial Adenomatous Polyposis (FAP)RecruitingNCT02656134
37Use of Curcumin for Treatment of Intestinal Adenomas in Familial Adenomatous Polyposis (FAP)RecruitingNCT00927485
38Curcumin in Treating Patients With Familial Adenomatous PolyposisRecruitingNCT00641147
39Preliminary Evaluation of Septin9 in Patients With Hereditary Colon Cancer SyndromesRecruitingNCT02198092
40Adenoma Detection Rate:NBI, AFI, Chromoscopic or Standard EndoscopyRecruitingNCT00253812
4118F-FES PET/CT in Imaging Patients With Desmoid TumorsRecruitingNCT02374931
42Cancer Research Repository for Individuals With Cancer Diagnosis and High Risk Individuals.RecruitingNCT02012699
43Prevalence of Small Bowel Polyps in Patients With Sporadic Duodenal AdenomasRecruitingNCT02470416
44French Digestive Polyposis Cohorte Family Adenomatous Polyposis With APC and MYH Gene Mutations , Cowden's Disease With PTEN Gene Mutation, Peutz Jeghers Disease With STK 11 Gene Mutation ,juvénil Polyposis With SMAD 4 Gene Mutation , Serrated and HyperplRecruitingNCT01987518
45Collecting Information From Patients and Family Members With Hereditary Colorectal Cancer Syndromes or Who Are at High Risk of Developing Colorectal CancerRecruitingNCT00675636
46Ileal Pouch-Anal Anastomosis RegistryRecruitingNCT01026480
47Familial Cancer Registry and DNA BankRecruitingNCT02083224
48Multimedia Intervention in Patients With Familial Adenomatous Polyposis (FAP)Active, not recruitingNCT00525655
49Chemoprevention of Gastric Cancer by Intervention With Helicobacter Pylori and Cyclooxygenase PathwayActive, not recruitingNCT00498134
50Inflammatory Bowel Disease(IBD)DatabaseNot yet recruitingNCT01266538

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Cochrane evidence based reviews: Adenomatous Polyposis Coli

Genetic Tests for Familial Adenomatous Polyposis

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Genetic tests related to Familial Adenomatous Polyposis:

id Genetic test Affiliating Genes
1 Familial Adenomatous Polyposis22
2 Familial Multiple Polyposis Syndrome24

Anatomical Context for Familial Adenomatous Polyposis

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MalaCards organs/tissues related to Familial Adenomatous Polyposis:

33
Colon, Bone, Skin, Small intestine, Thyroid, Testes, Pancreas

Animal Models for Familial Adenomatous Polyposis or affiliated genes

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MGI Mouse Phenotypes related to Familial Adenomatous Polyposis:

38 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.0APC, CTNNB1, KRAS, MYC, TP53
2MP:00053719.6APC, AXIN1, CTNNB1, KRAS, MYC, TP53
3MP:00030129.4APC, CDH1, CTNNB1, GSK3B, MYC, PTGS2
4MP:00053829.3APC, AXIN1, CCND1, CTNNB1, GSK3B, MYC
5MP:00053909.2APC, AXIN1, CCND1, CTNNB1, GSK3B, MYC
6MP:00053679.0APC, AXIN1, CTNNB1, GSK3B, KRAS, PTGS2
7MP:00053708.7APC, CTNNB1, GSK3B, HNF4A, KRAS, MYC
8MP:00053808.5APC, AXIN1, CDH1, CTNNB1, HNF4A, KRAS
9MP:00053858.2APC, AXIN1, CCND1, CDH1, CTNNB1, GSK3B
10MP:00053978.0APC, CCND1, CTNNB1, KRAS, MSH2, MYC
11MP:00107717.9APC, CCND1, CDH1, CTNNB1, KRAS, MLH1
12MP:00053797.9APC, CCND1, CDH1, CTNNB1, GSK3B, KRAS
13MP:00053817.9APC, AXIN1, CCND1, CDH1, CTNNB1, GSK3B
14MP:00028737.8APC, AXIN1, CCND1, CDH1, CTNNB1, GSK3B
15MP:00053787.6APC, APC2, AXIN1, CCND1, CDH1, CTNNB1
16MP:00053867.6APC, APC2, AXIN1, CCND1, CTNNB1, GSK3B
17MP:00053877.5APC, CCND1, CDH1, CTNNB1, GSK3B, KRAS
18MP:00053897.4APC, APC2, AXIN1, CCND1, CDH1, CTNNB1
19MP:00020067.3APC, CCND1, CDH1, CTNNB1, KRAS, MLH1
20MP:00107687.0APC, AXIN1, CCND1, CDH1, CTNNB1, GSK3B
21MP:00036317.0APC, APC2, AXIN1, CCND1, CTNNB1, GSK3B
22MP:00053846.7APC, APC2, AXIN1, CCND1, CDH1, CTNNB1
23MP:00053766.6APC, CCND1, CDH1, CTNNB1, GSK3B, HNF4A

Publications for Familial Adenomatous Polyposis

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Articles related to Familial Adenomatous Polyposis:

(show top 50)    (show all 796)
idTitleAuthorsYear
1
Characteristics of benign and malignant thyroid disease in familial adenomatous polyposis patients and recommendations for disease surveillance. (25585202)
2015
2
Cribiform variant of papillary thyroid cancer and familial adenomatous polyposis. (26521198)
2015
3
Cell reconstruction of the rectal mucosa in patients with familial adenomatous polyposis: endoscopy, morphology, immunohistochemistry. (25257440)
2014
4
Desmoid tumour biology in patients with familial adenomatous polyposis coli. (23334997)
2013
5
Ursodeoxycholic acid counteracts celecoxib in reduction of duodenal polyps in patients with familial adenomatous polyposis: a multicentre, randomized controlled trial. (23919274)
2013
6
Screening and Health Behaviors among Persons Diagnosed with Familial Adenomatous Polyposis and Their Relatives. (22899922)
2012
7
Severe duodenal involvement in familial adenomatous polyposis treated by pylorus-preserving pancreaticoduodenectomy. (22311120)
2012
8
A De Novo Germline APC Mutation (3927del5) in a Patient with Familial Adenomatous Polyposis: Case Report and Literature Review. (23115482)
2012
9
Imaging assessment of desmoid tumours in familial adenomatous polyposis: is state-of-the-art 1.5 T MRI better than 64-MDCT? (22215881)
2012
10
Perinatal detection of familial adenomatous polyposis. (22825279)
2012
11
The genetics of familial adenomatous polyposis (FAP) and MutYH-associated polyposis (MAP). (22103048)
2011
12
Modified multivisceral transplantation with spleen-preserving pancreaticoduodenectomy for patients with familial adenomatous polyposis "Gardner's Syndrome". (21512435)
2011
13
Clinical and genetic characterization of classical forms of familial adenomatous polyposis: a Spanish population study. (20924072)
2011
14
Prevalence of gastric and duodenal polyps and risk factors for duodenal neoplasm in korean patients with familial adenomatous polyposis. (21461071)
2011
15
Attenuated familial adenomatous polyposis: results from an international collaborative study. (20105204)
2010
16
A distinct mutation on the alternative splice site of APC exon 9 results in attenuated familial adenomatous polyposis phenotype. (20033787)
2010
17
A novel frameshift mutation in exon 12 of the adenomatous polyposis coli gene in an Italian family with familial adenomatous polyposis and desmoid tumour. (20589194)
2010
18
Neonatal Gardner fibroma: a sentinel presentation of severe familial adenomatous polyposis. (21059714)
2010
19
Familial adenomatous polyposis-associated ampullary adenoma: response to chemotherapy for concurrent metastatic adenocarcinoma. (19245848)
2009
20
APC mutation spectrum of Norwegian familial adenomatous polyposis families: high ratio of novel mutations. (19444466)
2009
21
Novel cell culture model for prevention of carcinogenic risk in familial adenomatous polyposis syndrome. (19288003)
2009
22
Rectal and pouch recurrences after surgical treatment for familial adenomatous polyposis. (18766422)
2009
23
Identification of somatic APC mutations in recurrent desmoid tumors in a patient with familial adenomatous polyposis to determine actual recurrence of the original tumor or de novo occurrence. (18704758)
2009
24
Chromoendoscopy, narrow-band imaging colonoscopy, and autofluorescence colonoscopy for detection of diminutive colorectal neoplasia in familial adenomatous polyposis. (19581862)
2009
25
Magnified endoscopic observation using narrow-band imaging of periampullary adenoma in a patient with familial adenomatous polyposis. (19946237)
2009
26
Familial adenomatous polyposis in children younger than age ten years: a multidisciplinary clinic experience. (18157572)
2008
27
Is capsule endoscopy safe and useful for small-bowel surveillance in patients with familial adenomatous polyposis? (18607405)
2008
28
Adenocarcinoma arising in the ileoanal pouch after restorative proctocolectomy for familial adenomatous polyposis. (18030481)
2008
29
A papillary thyroid carcinoma case associated with hereditary colon carcinoma due to familial adenomatous polyposis with no hereditary mutation finding. (15834731)
2007
30
Deletion mutation of BRAF in a serrated adenoma from a patient with familial adenomatous polyposis. (17696956)
2007
31
Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP). (17486639)
2007
32
Attitudes toward prenatal genetic testing in patients with familial adenomatous polyposis. (17355417)
2007
33
Familial adenomatous polyposis complicated with Crohn's disease. (16775703)
2006
34
Genetic polymorphisms of flavin monooxygenase 3 in sulindac-induced regression of colorectal adenomas in familial adenomatous polyposis. (16214918)
2005
35
APC germ-line mutations in southern Spanish patients with familial adenomatous polyposis: genotype-phenotype correlations and identification of eight novel mutations. (15857185)
2005
36
Lung adenocarcinoma associated with familial adenomatous polyposis. Clear cell carcinoma with beta-catenin accumulation accompanied by atypical adenomatous hyperplasia. (15660284)
2005
37
High-grade pancreatic intraepithelial neoplasia in a patient with familial adenomatous polyposis. (16253018)
2005
38
Familial adenomatous polyposis and mental retardation caused by a de novo chromosomal deletion at 5q15-q22: report of a case. (16228830)
2005
39
Familial adenomatous polyposis syndrome (FAP): pathogenesis and molecular mechanisms]. (14685680)
2003
40
Rectal epithelial apoptosis in familial adenomatous polyposis patients treated with sulindac. (10562579)
1999
41
Germline mutations are frequent in the APC gene but absent in the beta-catenin gene in familial adenomatous polyposis patients. (10398435)
1999
42
Genetic diagnosis of familial adenomatous polyposis: detection of APC gene mutations based on an in vitro synthetized protein]. (9580364)
1998
43
Childhood hepatocellular adenoma in familial adenomatous polyposis: mutations in adenomatous polyposis coli gene and p53. (9041254)
1997
44
Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. (9378405)
1997
45
Sulindac induced regression of colorectal adenomas in familial adenomatous polyposis: evaluation of predictive factors. (8707091)
1996
46
p53 Protein overexpression in colorectal tumors from patients with familial adenomatous polyposis: is it an early or late event? (8561108)
1996
47
Desmoids in familial adenomatous polyposis. (9014661)
1996
48
Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. (9038672)
1996
49
The clinical [corrected] background of familial adenomatous polyposis. History, epidemiology, diagnosis and treatment. (7571988)
1995
50
Facioscapulohumeral muscular dystrophy gene in Dutch families is not linked to markers for familial adenomatous polyposis on the long arm of chromosome 5. (2157824)
1990

Variations for Familial Adenomatous Polyposis

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Clinvar genetic disease variations for Familial Adenomatous Polyposis:

5 (show all 27)
id Gene Variation Type Significance SNP ID Assembly Location
1MUTYHNM_001128425.1(MUTYH): c.1227_1228dupGG (p.Glu410Glyfs)duplicationPathogenicrs587780078GRCh37Chr 1, 45797187: 45797188
2MUTYHNM_001128425.1(MUTYH): c.1437_1439delGGA (p.Glu480del)deletionPathogenicrs587778541GRCh37Chr 1, 45796891: 45796893
3MUTYHNM_001128425.1(MUTYH): c.1640delC (p.Ala547Glufs)deletionPathogenicrs587780086GRCh37Chr 1, 45794988: 45794988
4MUTYHNM_001128425.1(MUTYH): c.1147delC (p.Ala385Profs)deletionPathogenicrs587778536GRCh38Chr 1, 45331700: 45331700
5MUTYHNM_001128425.1(MUTYH): c.736G> T (p.Val246Phe)single nucleotide variantLikely pathogenic, Pathogenicrs587780749GRCh37Chr 1, 45798115: 45798115
6MUTYHNM_001128425.1(MUTYH): c.933+3A> Csingle nucleotide variantPathogenicrs587780751GRCh37Chr 1, 45797835: 45797835
7MUTYHNM_001128425.1(MUTYH): c.734G> A (p.Arg245His)single nucleotide variantPathogenicrs140342925GRCh37Chr 1, 45798117: 45798117
8MUTYHNM_001128425.1(MUTYH): c.1214C> T (p.Pro405Leu)single nucleotide variantPathogenicrs529008617GRCh38Chr 1, 45331529: 45331529
9MUTYHNM_001128425.1(MUTYH): c.545G> A (p.Arg182His)single nucleotide variantPathogenicrs143353451GRCh38Chr 1, 45332794: 45332794
10MUTYHNM_001128425.1(MUTYH): c.857G> A (p.Gly286Glu)single nucleotide variantPathogenicrs730881833GRCh38Chr 1, 45332242: 45332242
11MUTYHNM_001128425.1(MUTYH): c.309G> A (p.Trp103Ter)single nucleotide variantPathogenicrs748170941GRCh37Chr 1, 45799124: 45799124
12MUTYHNM_001128425.1(MUTYH): c.799C> T (p.Gln267Ter)single nucleotide variantPathogenicrs786203115GRCh37Chr 1, 45797972: 45797972
13MUTYHNM_001128425.1(MUTYH): c.1214_1224delCGTCCGTGACC (p.Pro405Leufs)deletionPathogenicGRCh37Chr 1, 45797191: 45797201
14MUTYHNM_001128425.1(MUTYH): c.1474A> T (p.Lys492Ter)single nucleotide variantPathogenicGRCh37Chr 1, 45796856: 45796856
15MUTYHNM_001128425.1(MUTYH): c.349-?_*(1_?)deldeletionPathogenicGRCh37Chr 1, 45794977: 45798996
16MUTYHNM_001128425.1(MUTYH): c.348+33_*210delinsTAindelPathogenicGRCh38Chr 1, 45329096: 45333380
17MUTYHNM_001128425.1(MUTYH): c.1418C> A (p.Ala473Asp)single nucleotide variantPathogenicrs200844166GRCh37Chr 1, 45796912: 45796912
18MUTYHNM_001128425.1(MUTYH): c.733C> T (p.Arg245Cys)single nucleotide variantLikely pathogenic, Pathogenicrs200495564GRCh37Chr 1, 45798118: 45798118
19MUTYHNM_001128425.1(MUTYH): c.934-2A> Gsingle nucleotide variantLikely pathogenic, Pathogenicrs77542170GRCh37Chr 1, 45797760: 45797760
20MUTYHNM_001128425.1(MUTYH): c.536A> G (p.Tyr179Cys)single nucleotide variantPathogenicrs34612342GRCh37Chr 1, 45798475: 45798475
21MUTYHNM_001128425.1(MUTYH): c.1187G> A (p.Gly396Asp)single nucleotide variantPathogenicrs36053993GRCh37Chr 1, 45797228: 45797228
22MUTYHNM_001128425.1(MUTYH): c.1461delC (p.Thr488Profs)deletionPathogenicrs587776618GRCh37Chr 1, 45796869: 45796869
23MUTYHNM_001128425.1(MUTYH): c.312C> A (p.Tyr104Ter)single nucleotide variantPathogenicrs121908380GRCh37Chr 1, 45799121: 45799121
24MUTYHNM_001128425.1(MUTYH): c.1438G> T (p.Glu480Ter)single nucleotide variantPathogenicrs121908381GRCh37Chr 1, 45796892: 45796892
25APCNM_000038.5(APC): c.2805C> A (p.Tyr935Ter)single nucleotide variantPathogenicrs137854575GRCh37Chr 5, 112174096: 112174096
26APCNM_000038.5(APC): c.3927_3931delAAAGA (p.Glu1309Aspfs)deletionPathogenicrs121913224GRCh37Chr 5, 112175218: 112175222
27APCNM_000038.5(APC): c.3920T> A (p.Ile1307Lys)single nucleotide variantPathogenic, risk factorrs1801155GRCh37Chr 5, 112175211: 112175211

Cosmic variations for Familial Adenomatous Polyposis:

7 (show top 50)    (show all 76)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
110660TP53large intestine,rectum,adenoma,NS3
210870TP53large intestine,rectum,adenoma,NS3
345076TP53large intestine,rectum,adenoma,NS3
410957TP53large intestine,colon,adenoma,NS3
543606TP53large intestine,rectum,adenoma,NS3
66932TP53large intestine,colon,adenoma,NS3
745138TP53large intestine,rectum,adenoma,NS3
845139TP53large intestine,colon,adenoma,NS3
9520KRASlarge intestine,rectum,adenoma,NS3
10518KRASlarge intestine,colon,adenoma,NS3
11554KRASlarge intestine,rectum,adenoma,NS3
12521KRASlarge intestine,rectum,adenoma,NS3
13522KRASlarge intestine,colon,adenoma,NS3
14532KRASlarge intestine,colon,adenoma,NS3
15517KRASlarge intestine,rectum,adenoma,NS3
16516KRASlarge intestine,colon,adenoma,NS3
17460BRAFsmall intestine,duodenum,adenoma,NS3
1821492BRAFlarge intestine,colon,adenoma,NS3
19467BRAFlarge intestine,colon,adenoma,NS3
2021493BRAFlarge intestine,colon,adenoma,NS3
211131BRAFlarge intestine,colon,adenoma,NS3
22476BRAFsmall intestine,duodenum,adenoma,NS3
235687CTNNB1large intestine,rectum,adenoma,NS3
245664CTNNB1large intestine,colon,adenoma,NS3
2513153CTNNB1large intestine,colon,adenoma,NS3
265671CTNNB1large intestine,colon,adenoma,NS3
275667CTNNB1large intestine,colon,adenoma,NS3
2814241SMAD4large intestine,colon,adenoma,NS3
2914240SMAD4large intestine,colon,adenoma,NS3
3030598FBXW7large intestine,colon,adenoma,NS3
3130597FBXW7large intestine,rectum,adenoma,NS3
3219370APClarge intestine,colon,adenoma,NS3
3319382APCsmall intestine,duodenum,adenoma,NS3
341166144BIRC6large intestine,rectum,adenoma,NS3
351166128PPP2R1Blarge intestine,rectum,adenoma,NS3
361166156CDH10large intestine,rectum,adenoma,NS3
371166183NTRK2large intestine,rectum,adenoma,NS3
381165494TGIF1large intestine,colon,adenoma,NS3
391165523HCFC1large intestine,colon,adenoma,NS3
401166119DCST1large intestine,rectum,adenoma,NS3
411165150ALKlarge intestine,rectum,adenoma,NS3
42564NRASlarge intestine,rectum,adenoma,NS3
431103146ANKS6large intestine,colon,adenoma,NS3
441165818MATKlarge intestine,colon,adenoma,NS3
4521354STK11large intestine,colon,adenoma,NS3
4614062ERBB2large intestine,colon,adenoma,NS3
471166351ZNF648large intestine,colon,adenoma,NS3
481165833PPP1R16Blarge intestine,colon,adenoma,NS3
4927895GNASlarge intestine,colon,adenoma,NS3
501165768RUNX2large intestine,colon,adenoma,NS3

Expression for genes affiliated with Familial Adenomatous Polyposis

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Search GEO for disease gene expression data for Familial Adenomatous Polyposis.

Pathways for genes affiliated with Familial Adenomatous Polyposis

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Pathways related to Familial Adenomatous Polyposis according to GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CCND1, CDH1, CTNNB1
29.8CTNNB1, MYC, TP53
39.8MLH1, MSH2, MSH6
49.6AXIN1, GSK3B, MYC
59.6AXIN1, CTNNB1, MAPRE1
69.6APC, AXIN1, CTNNB1, GSK3B
79.6CCND1, MYC, PTGS2, TP53
89.5MLH1, MSH2, MSH6, TP53
99.4GSK3B, KRAS, MYC, TP53
109.4CCND1, MSH6, MYC, TP53
119.4CCND1, CTNNB1, GSK3B, SMAD4
129.4APC, CCND1, CDH1, CTNNB1, MYC
139.4APC, AXIN1, CDH1, CTNNB1, GSK3B
149.3CCND1, CTNNB1, KRAS, MYC, TP53
159.3HNF4A, KRAS, MYC, SMAD4
169.3GSK3B, MYC, SMAD4, TP53
179.3CCND1, CDH1, KRAS, MYC, TP53
189.2APC, AXIN1, CTNNB1, GSK3B, SMAD4
199.2AXIN1, CDH1, CTNNB1, GSK3B, MYC
20
Show member pathways
9.2CCND1, MSH2, MSH6, MYC, TP53
21
Show member pathways
9.2CCND1, GSK3B, KRAS, MYC, TP53
22
Show member pathways
9.2CDH1, CTNNB1, GSK3B, KRAS, MYC
23
Show member pathways
9.1CCND1, KRAS, MYC, SMAD4, TP53
249.1APC, AXIN1, CDH1, CTNNB1, GSK3B, KRAS
259.1APC, AXIN1, CCND1, CTNNB1, GSK3B, MYC
269.1CCND1, CDH1, CTNNB1, KRAS, MYC, TP53
279.0CCND1, CTNNB1, GSK3B, KRAS, MYC, TP53
28
Show member pathways
9.0APC, AXIN1, CTNNB1, GSK3B, HNF4A, SMAD4
29
Show member pathways
8.9APC, CDH1, CTNNB1, GSK3B, KRAS, PTGS2
30
Show member pathways
8.9CCND1, GSK3B, MSH2, MSH6, MYC, TP53
318.9APC, APC2, CCND1, KRAS, MYC, PTGS2
32
Show member pathways
8.9APC, APC2, AXIN1, CTNNB1, GSK3B, KRAS
338.8CCND1, CDH1, GSK3B, MYC, SMAD4, TP53
348.8AXIN1, CCND1, CTNNB1, HNF4A, MYC, SMAD4
35
Show member pathways
8.7CCND1, CDH1, CTNNB1, GSK3B, KRAS, MSH6
368.7CCND1, MAPRE1, MLH1, MSH2, MSH6, MUTYH
37
Show member pathways
8.7APC, AXIN1, CTNNB1, GSK3B, KRAS, MYC
388.6APC, AXIN1, CCND1, CTNNB1, GSK3B, KRAS
39
Wnt Signaling Pathway (WikiPathways)
Show member pathways
8.5APC, AXIN1, CCND1, CTNNB1, GSK3B, KRAS
408.4APC, APC2, AXIN1, CTNNB1, GSK3B, KRAS
418.4APC, CCND1, CTNNB1, HNF4A, KRAS, MYC
428.2APC, AXIN1, CCND1, CDH1, CTNNB1, GSK3B
438.2APC, APC2, CCND1, CTNNB1, GSK3B, KRAS
448.2APC, APC2, AXIN1, CCND1, CDH1, CTNNB1
458.2CCND1, CDH1, CTNNB1, KRAS, MSH2, MSH6
46
Wnt signaling pathway (KEGG)
Show member pathways
8.0CCND1, CDH1, CTNNB1, KRAS, MSH2, MSH6
47
Show member pathways
7.6APC, AXIN1, CCND1, CDH1, CTNNB1, GSK3B
487.3APC, CCND1, CDH1, CTNNB1, GSK3B, KRAS
49
Show member pathways
7.0APC, APC2, AXIN1, CCND1, CDH1, CTNNB1
506.8APC, APC2, AXIN1, CCND1, CDH1, CTNNB1

GO Terms for genes affiliated with Familial Adenomatous Polyposis

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Cellular components related to Familial Adenomatous Polyposis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1MutSalpha complexGO:003230110.7MSH2, MSH6
2flotillin complexGO:001660010.7CDH1, CTNNB1
3cell-cell adherens junctionGO:000591310.5APC, CDH1, CTNNB1
4cell projection membraneGO:003125310.4APC, CTNNB1, MAPRE1
5catenin complexGO:001634210.3APC, APC2, CDH1, CTNNB1
6cytoplasmic microtubuleGO:000588110.0APC, APC2, AXIN1, MAPRE1
7beta-catenin destruction complexGO:00308779.9APC, APC2, AXIN1, CTNNB1, GSK3B
8lamellipodiumGO:00300279.8APC, CDH1, CTNNB1, MCC
9lateral plasma membraneGO:00163289.7APC, AXIN1, CDH1, CTNNB1
10centrosomeGO:00058139.4APC, CTNNB1, GSK3B, MAPRE1, SMAD4
11protein complexGO:00432349.3AXIN1, CTNNB1, MYC, PTGS2, TP53
12nucleoplasmGO:00056547.5APC, CCND1, CTNNB1, GSK3B, HNF4A, MCC
13cytosolGO:00058297.5APC, AXIN1, CCND1, CTNNB1, GSK3B, KRAS
14nucleusGO:00056346.6APC, AXIN1, CCND1, CTNNB1, GSK3B, HNF4A
15cytoplasmGO:00057376.1APC, APC2, AXIN1, CCND1, CDH1, CTNNB1

Biological processes related to Familial Adenomatous Polyposis according to GeneCards Suite gene sharing:

(show all 48)
idNameGO IDScoreTop Affiliating Genes
1somatic recombination of immunoglobulin genes involved in immune responseGO:000220410.8MLH1, MSH2
2positive regulation of epithelial cell differentiationGO:003085810.8APC, CTNNB1
3canonical Wnt signaling pathway involved in negative regulation of apoptotic processGO:004433610.8APC, CTNNB1
4dorsal/ventral axis specificationGO:000995010.8AXIN1, CTNNB1
5regulation of epithelial cell differentiationGO:003085610.7APC, CTNNB1
6re-entry into mitotic cell cycleGO:000032010.7CCND1, GSK3B
7meiotic mismatch repairGO:000071010.7MSH2, MSH6
8canonical Wnt signaling pathway involved in positive regulation of apoptotic processGO:004433710.7APC, GSK3B
9positive regulation of helicase activityGO:005109610.7MSH2, MSH6
10negative regulation of DNA recombinationGO:004591010.6MSH2, MSH6
11cellular response to indole-3-methanolGO:007168110.6CDH1, CTNNB1
12maintenance of DNA repeat elementsGO:004357010.6MSH2, MSH6
13ER overload responseGO:000698310.6GSK3B, TP53
14cell fate specificationGO:000170810.5APC, APC2, CTNNB1
15T cell differentiation in thymusGO:003307710.5APC, CTNNB1, TP53
16regulation of cell differentiationGO:004559510.5APC, APC2, CTNNB1
17somatic recombination of immunoglobulin gene segmentsGO:001644710.5MLH1, MSH2, MSH6
18somatic hypermutation of immunoglobulin genesGO:001644610.4MLH1, MSH2, MSH6
19response to X-rayGO:001016510.4CCND1, MSH2, TP53
20chromosome organizationGO:005127610.4APC, MYC, TP53
21determination of adult lifespanGO:000834010.3MSH2, MSH6, TP53
22response to glucocorticoidGO:005138410.3CCND1, KRAS, PTGS2
23isotype switchingGO:004519010.3MLH1, MSH2, MSH6
24intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.3MLH1, MSH2, MSH6
25mismatch repairGO:000629810.2MLH1, MSH2, MSH6, MUTYH
26cellular response to UVGO:003464410.2MYC, PTGS2, TP53
27cellular component disassembly involved in execution phase of apoptosisGO:000692110.2APC, CDH1, CTNNB1
28branching involved in ureteric bud morphogenesisGO:000165810.1CTNNB1, MYC, SMAD4
29negative regulation of Wnt signaling pathwayGO:003017810.1APC, APC2, AXIN1, CCND1
30reciprocal meiotic recombinationGO:000713110.1MLH1, MSH2, MSH6
31protein localization to microtubuleGO:003537210.1GSK3B, MAPRE1
32mitotic G1 DNA damage checkpointGO:003157110.1CCND1, TP53
33positive regulation of canonical Wnt signaling pathwayGO:009026310.0APC, AXIN1, CTNNB1, GSK3B
34cell cycle arrestGO:000705010.0APC, MSH2, MYC, TP53
35programmed cell deathGO:001250110.0APC, CDH1, CTNNB1, TP53
36positive regulation of protein catabolic processGO:00457329.9APC, APC2, AXIN1, GSK3B
37in utero embryonic developmentGO:00017019.8AXIN1, CTNNB1, MSH2, SMAD4, TP53
38regulation of cell proliferationGO:00421279.7CTNNB1, PTGS2, SMAD4, TP53
39canonical Wnt signaling pathwayGO:00600709.7APC, AXIN1, CCND1, CTNNB1, GSK3B, MYC
40positive regulation of cell proliferationGO:00082849.5CCND1, CTNNB1, KRAS, MYC, PTGS2
41negative regulation of cell proliferationGO:00082859.5APC, CTNNB1, HNF4A, PTGS2, SMAD4, TP53
42negative regulation of canonical Wnt signaling pathwayGO:00900909.5APC, APC2, AXIN1, GSK3B, MCC
43cell proliferationGO:00082839.2APC2, CTNNB1, MAPRE1, SMAD4, TP53
44cellular response to DNA damage stimulusGO:00069749.1APC, CCND1, MLH1, MSH2, MYC, TP53
45Wnt signaling pathwayGO:00160559.1APC, APC2, AXIN1, CCND1, CTNNB1, GSK3B
46positive regulation of transcription, DNA-templatedGO:00458939.1AXIN1, CDH1, CTNNB1, HNF4A, MYC, SMAD4
47DNA repairGO:00062819.0MLH1, MSH2, MSH6, MUTYH, NUDT1, TP53
48response to drugGO:00424938.8CCND1, CDH1, CTNNB1, MYC, PTGS2, TP53

Molecular functions related to Familial Adenomatous Polyposis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1MutSalpha complex bindingGO:003240710.9MLH1, MUTYH
2guanine/thymine mispair bindingGO:003213710.7MSH2, MSH6
3single guanine insertion bindingGO:003214210.7MSH2, MSH6
4single thymine insertion bindingGO:003214310.7MSH2, MSH6
5oxidized purine DNA bindingGO:003235710.7MSH2, MSH6
6microtubule plus-end bindingGO:005101010.6APC, MAPRE1
7MutLalpha complex bindingGO:003240510.5MSH2, MSH6, MUTYH
8mismatched DNA bindingGO:003098310.5MLH1, MSH2, MSH6
9I-SMAD bindingGO:007041110.4AXIN1, CTNNB1, SMAD4
10R-SMAD bindingGO:007041210.4AXIN1, CTNNB1, SMAD4
11gamma-catenin bindingGO:004529510.4APC, APC2, CDH1
12p53 bindingGO:000203910.4AXIN1, GSK3B, TP53
13RNA polymerase II transcription factor bindingGO:000108510.3GSK3B, SMAD4, TP53
14damaged DNA bindingGO:000368410.2MSH2, MSH6, TP53
15double-stranded DNA bindingGO:000369010.1CTNNB1, MSH2, MSH6, TP53
16transcription regulatory region DNA bindingGO:004421210.0CTNNB1, HNF4A, SMAD4, TP53
17transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:000107710.0HNF4A, MYC, SMAD4, TP53
18beta-catenin bindingGO:00080139.8APC, APC2, AXIN1, CDH1, GSK3B
19protein kinase bindingGO:00199019.7APC, AXIN1, CCND1, GSK3B, MSH2, TP53
20enzyme bindingGO:00198999.7AXIN1, CCND1, CTNNB1, MSH2, PTGS2, TP53
21protein C-terminus bindingGO:00080229.5AXIN1, CTNNB1, MAPRE1, MSH2
22protein homodimerization activityGO:00428038.9AXIN1, HNF4A, MSH2, MSH6, PTGS2, SMAD4
23protein bindingGO:00055155.0APC, APC2, AXIN1, CCND1, CDH1, CTNNB1

Sources for Familial Adenomatous Polyposis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet