FAP
MCID: FML011
MIFTS: 93

Familial Adenomatous Polyposis (FAP) malady

Neuronal diseases, Eye diseases, Gastrointestinal diseases, Skin diseases, Fetal diseases, Cancer diseases, Genetic diseases categories

Summaries for Familial Adenomatous Polyposis

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8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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Genetics Home Reference:21 Familial adenomatous polyposis (FAP) is an inherited disorder characterized by cancer of the large intestine (colon) and rectum. People with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) growths (polyps) in the colon as early as their teenage years. Unless the colon is removed, these polyps will become malignant (cancerous). The average age at which an individual develops colon cancer in classic familial adenomatous polyposis is 39 years. Some people have a variant of the disorder, called attenuated familial adenomatous polyposis, in which polyp growth is delayed. The average age of colorectal cancer onset for attenuated familial adenomatous polyposis is 55 years.

MalaCards: Familial Adenomatous Polyposis, also known as adenomatous polyposis coli, is related to adenoma and colorectal cancer, and has symptoms including autosomal dominant inheritance, neoplasms/tumors and colon neoplasm/tumor/carcinoma/cancer. An important gene associated with Familial Adenomatous Polyposis is APC (adenomatous polyposis coli), and among its related pathways are Pathways in cancer and Wnt signaling pathway. The drug celecoxib and the compounds glycogen and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include colon, thyroid and testes, and related mouse phenotypes are cellular and mortality/aging.

Disease Ontology:8 An autosomal dominant disease that is caused by mutations in the apc gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

NIH Rare Diseases:42 Familial adenomatous polyposis (fap) is an inherited colorectal cancer syndrome. cancer usually develops in the lower part of the digestive system, including the large intestine (colon) and rectum. people with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) polyps (growths) in the colon as early as their teenage years. the average age at which an individual develops colon cancer in classic familial adenomatous polyposis is about 39 years. mutations in the apc gene cause classic familial adenomatous polyposis. last updated: 4/6/2010

Wikipedia:63 Familial adenomatous polyposis (FAP) is an inherited condition in which numerous adenomatous polyps form... more...

Description from OMIM:46 608456,175100

Aliases & Classifications for Familial Adenomatous Polyposis

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8Disease Ontology, 63Wikipedia, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 35MESH via Orphanet, 61UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
familial adenomatous polyposis:
Inheritance: Autosomal dominant,Autosomal recessive; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult
attenuated familial adenomatous polyposis:
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Adulthood


Aliases & Descriptions:

familial adenomatous polyposis 8 63 42 20 21 10 44 48
adenomatous polyposis coli 63 42 22 21 46 60
adenomatous polyposis of the colon 8 63 42
fap 63 21 48
familial multiple polyposis 42 22
myh-associated polyposis 21 60
gardner syndrome 48 60
apc-related attenuated familial adenomatous polyposis 48
apc-related attenuated familial polyposis coli 48
familial adenomatous polyposis of the colon 42
familial adenomatous polyposis, attenuated 60
attenuated familial adenomatous polyposis 48
adenomatous familial polyposis syndrome 21
familial multiple polyposis syndrome 21
attenuated familial polyposis coli 48
colorectal adenomatous polyposis 48
adenomatous familial polyposis 21
turcot syndrome with polyposis 48
familial intestinal polyposis 42
apc-related attenuated fap 48
atrial premature complexes 60
hereditary polyposis coli 63
familial polyposis coli 48
colon cancer, familial 63
apc-related afap 48
attenuated fap 48
polyposis coli 63
afap 48


External Ids:

Disease Ontology8 DOID:0050424
MeSH34 D011125
ICD10 via Orphanet26 D12.6
SNOMED-CT via Orphanet57 72900001, 70921007, 60876000
MESH via Orphanet35 C538265, D005736
UMLS via Orphanet61 C2674616, C0017097

Related Diseases for Familial Adenomatous Polyposis

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17GeneCards, 18GeneDecks
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Diseases in the Familial Adenomatous Polyposis family:

Familial Adenomatous Polyposis Due to 5q22.2 Microdeletion

Diseases related to Familial Adenomatous Polyposis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.6SMPD1, ENPP7, PTGS2, PTGER2, MSH2, MSH6
2colorectal cancer31.3ODC1, OGG1, APC, CTNNB1, MUTYH, MSH6
3adenocarcinoma31.2ODC1, KLF4, OGG1, APC, CTNNB1, PLA2G2A
4hepatoblastoma31.0APC, CTNNB1, AXIN2
5breast cancer30.9ODC1, CTNNB1, WNT1, MSH6, MSH2
6colon cancer30.9ODC1, APC, CTNNB1, AXIN2, MSH6, MSH2
7thyroid cancer30.9APC
8lynch syndrome30.9MSH2, MSH6
9pancreatitis30.8PLA2G2A
10squamous cell carcinoma30.8ODC1, KLF4, OGG1, APC, CTNNB1, WNT1
11lung cancer30.7PTGS2, PTGER2, OGG1, ODC1
12hepatocellular carcinoma30.7OGG1, APC, CTNNB1, MUTYH, WNT1, PTGS2
13desmoid tumor30.6APC, CTNNB1
14juvenile polyposis syndrome30.5APC
15gastric adenocarcinoma30.5ODC1, KLF4, APC, CTNNB1, PTGS2
16peutz-jeghers syndrome30.5CTNNB1, APC
17sarcoma30.5ODC1, WNT1, MSH2
18pancreatic cancer30.4KLF4, CTNNB1, WNT1, PLA2G2A, MSH2, PTGS2
19non-small cell lung carcinoma30.4ODC1, OGG1, APC, CTNNB1, WNT2, PTGS2
20melanoma30.3ODC1, CTNNB1, WNT2, PLA2G2A, MSH2
21medulloblastoma30.3APC, CTNNB1
22schizophrenia30.3PLA2G2A, ODC1
23stomach cancer30.3ODC1, APC, CTNNB1, PTGS2
24leukemia30.3ODC1, KLF4, OGG1, NUDT1, PLA2G2A, MSH2
25ovarian cancer30.2OGG1, CTNNB1, MSH6, MSH2
26muir-torre syndrome30.2MSH2, MSH6
27barrett's esophagus30.2PTGS2, APC, ODC1
28gardner syndrome30.2APC, CTNNB1
29turcot syndrome30.2MSH6, MSH2
30gastric cancer, somatic30.2APC, MUTYH
31rheumatoid arthritis30.1PLA2G2A, PTGS2
32arthritis30.1PTGS2, PLA2G2A
33astrocytoma30.1MSH2, PLA2G2A
34meningioma30.0ODC1
35ischemia30.0PLA2G2A
36fibromatosis30.0CTNNB1, APC
37prostate cancer30.0ODC1, CTNNB1, WNT2, WNT1
38duodenitis11.0
39thyroiditis10.8
40ulcerative colitis10.8
41attenuated familial adenomatous polyposis10.7
42papillary carcinoma10.7
43papillary thyroid carcinoma10.7
44polyneuropathy10.5
45neuronitis10.5
46cribriform carcinoma10.5
47nasopharyngitis10.5
48gastroduodenitis10.5
49mutyh-associated polyposis10.5
50familial adenomatous polyposis due to 5q22.2 microdeletion10.5

Graphical network of the top 20 diseases related to Familial Adenomatous Polyposis:



Diseases related to familial adenomatous polyposis

Clinical Features for Familial Adenomatous Polyposis

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46OMIM, 48Orphanet
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Clinical features from OMIM:

608456,175100

Clinical synopsis from OMIM:

175100

Symptoms:

48 (show all 12)
  • autosomal dominant inheritance
  • neoplasms/tumors
  • colon neoplasm/tumor/carcinoma/cancer
  • supernumerary teeth/polyodontia
  • delayed dentition/eruption of teeth/lack of eruption of teeth
  • dental cysts/tumors
  • irregular/in bands/reticular skin hyperpigmentation
  • xanthomas/lipomas
  • fibromatosis/bone fibroma
  • sarcoma
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • polyposis of the bowel/colon/intestine

Drugs & Therapeutics for Familial Adenomatous Polyposis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Familial Adenomatous Polyposis

Drug clinical trials:

Search ClinicalTrials for Familial Adenomatous Polyposis

Search NIH Clinical Center for Familial Adenomatous Polyposis

Search CenterWatch for Familial Adenomatous Polyposis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Familial Adenomatous Polyposis

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20GeneTests, 22GTR
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Genetic tests related to Familial Adenomatous Polyposis:

id Genetic test Affiliating Genes
1 Familial Adenomatous Polyposis20
2 Adenomatous Polyposis Coli22
3 Familial Multiple Polyposis Syndrome22

Anatomical Context for Familial Adenomatous Polyposis

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32MalaCards
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MalaCards organs/tissues related to Familial Adenomatous Polyposis:

32
Colon, Thyroid, Testes, Skin, Pancreas, Bone, Eye, Small intestine, Lung, Brain, Kidney, Liver, Testis, Spleen, T cells

Animal Models for Familial Adenomatous Polyposis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Familial Adenomatous Polyposis:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.4CTNNB1, APC2, APC, OGG1, KLF4, ODC1
2MP:001076811.4MUTYH, CTNNB1, APC, OGG1, KLF4, ODC1
3MP:000200611.3ENPP7, KLF4, OGG1, APC, CTNNB1, MUTYH
4MP:000363111.2OGG1, APC, APC2, CTNNB1, MUTYH, NUDT1
5MP:000538611.1KLF4, OGG1, CSNK1E, APC, APC2, CTNNB1
6MP:000539711.0OGG1, APC, CTNNB1, NUDT1, WNT1, MSH2
7MP:000537611.0KLF4, MUTYH, WNT2, MSH6, PTGER2, ENPP7
8MP:000538710.9OGG1, APC, CTNNB1, NUDT1, WNT1, MSH2
9MP:000538010.8APC, CTNNB1, AXIN2, WNT2, WNT1, PTGS2
10MP:000538910.8KLF4, APC, APC2, CTNNB1, PTGS2
11MP:000537910.5KLF4, AXIN2, ENPP7
12MP:001077110.4PTGS2, PTGER2, CTNNB1, APC

Publications for Familial Adenomatous Polyposis

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50PubMed
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Articles related to Familial Adenomatous Polyposis:

(show top 50)    (show all 752)
idTitleAuthorsYear
1
Desmoid tumour biology in patients with familial adenomatous polyposis coli. (23334997)
2013
2
Mucoepidermoid carcinoma: A yet unreported cancer associated with familial adenomatous polyposis. (23830771)
2013
3
APC germline mutations in individuals being evaluated for familial adenomatous polyposis: a review of the Mayo Clinic experience with 1591 consecutive tests. (23159591)
2013
4
Diagnosis, surveillance, and treatment strategies for familial adenomatous polyposis: rationale and update. (24161962)
2013
5
Preventive effects of low-dose aspirin on colorectal adenoma growth in patients with familial adenomatous polyposis: double-blind, randomized clinical trial. (24133627)
2013
6
Case report: metachronous central nervous system desmoid tumours and thyroid carcinoma in a young familial adenomatous polyposis patient. (23604857)
2013
7
Depressed-Type Colonic Lesions and "De Novo" Cancer in Familial Adenomatous Polyposis: A Colonoscopist's Viewpoint. (23533795)
2013
8
Comparison between Capsule Endoscopy and Magnetic Resonance Enterography for the Detection of Polyps of the Small Intestine in Patients with Familial Adenomatous Polyposis. (22518115)
2012
9
The effect of ursodesoxycholic acid on duodenal adenomas in familial adenomatous polyposis: a prospective randomized placebo-control trial. (21899713)
2012
10
Clinical utility gene card for: familial adenomatous polyposis (FAP) and attenuated FAP (AFAP). (21368914)
2011
11
Hepatocellular adenoma containing hepatocellular carcinoma in a male patient with familial adenomatous polyposis coli: Report of a case. (21922375)
2011
12
Intestinal pouch complications in patients who underwent restorative proctocolectomy for ulcerative colitis and familial adenomatous polyposis in 1985-2008. (22166319)
2011
13
Mucosectomy with handsewn anastomosis reduces the risk of adenoma formation in the anorectal segment after restorative proctocolectomy for familial adenomatous polyposis. (21173697)
2011
14
A novel frameshift mutation in exon 12 of the adenomatous polyposis coli gene in an Italian family with familial adenomatous polyposis and desmoid tumour. (20589194)
2010
15
Familial adenomatous polyposis in children and adolescents. (20808249)
2010
16
Long-term compliance with endoscopic surveillance for familial adenomatous polyposis. (19604286)
2010
17
The impact of screening and genetic registration on mortality and colorectal cancer incidence in familial adenomatous polyposis. (20660077)
2010
18
Jejunal cancer in patients with familial adenomatous polyposis. (20621624)
2010
19
APC mutation spectrum of Norwegian familial adenomatous polyposis families: high ratio of novel mutations. (19444466)
2009
20
Magnified endoscopic observation using narrow-band imaging of periampullary adenoma in a patient with familial adenomatous polyposis. (19946237)
2009
21
A useful reconstruction arrangement following Whipple's resection for patients with familial adenomatous polyposis. (19842250)
2009
22
Adenocarcinoma arising in the ileoanal pouch after restorative proctocolectomy for familial adenomatous polyposis. (18030481)
2008
23
Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome. (18672142)
2008
24
Gastric adenocarcinoma arising from fundic gland polyps in a patient with familial adenomatous polyposis syndrome. (18274437)
2008
25
Germline hypermethylation of the APC promoter is not a frequent cause of familial adenomatous polyposis in APC/MUTYH mutation negative families. (18027849)
2008
26
A desmoid tumor-staging system separates patients with intra-abdominal, familial adenomatous polyposis-associated desmoid disease by behavior and prognosis. (18322756)
2008
27
Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. (18632633)
2008
28
Strategies and outcomes of PGD of familial adenomatous polyposis. (17114207)
2007
29
An investigation on the nature of the peptide at m/z 904, overexpressed in plasma of patients with colorectal cancer and familial adenomatous polyposis. (18085540)
2007
30
Spontaneous regression of rectal polyps following abdominal colectomy and ileorectal anastomosis for familial adenomatous polyposis, without sulindac treatment: report of four cases. (17611924)
2007
31
Impact of surgery on the development of duodenal cancer in patients with familial adenomatous polyposis. (17103055)
2006
32
Frequency of small bowel polyps in patients with duodenal adenoma but without familial adenomatous polyposis. (16514568)
2006
33
Colonic and duodenal flat adenomas in children with classical familial adenomatous polyposis. (16703174)
2006
34
Large mesenteric gastrointestinal stromal tumor in a patient with familial adenomatous polyposis syndrome. (16855925)
2006
35
Loss of extracellular E-cadherin in the normal mucosa of duodenum and colon of patients with familial adenomatous polyposis. (16949915)
2006
36
Surveillance and management of upper gastrointestinal disease in Familial Adenomatous Polyposis. (16998672)
2006
37
Sulindac inhibits beta-catenin expression in normal-appearing colon of hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis patients. (16030090)
2005
38
Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers. (15502862)
2004
39
Genetic and clinical characterisation of familial adenomatous polyposis: a population based study. (12010888)
2002
40
Duodenal adenomatosis in familial adenomatous polyposis coli. A review of the literature and results from the Heidelberg Polyposis Register. (11355321)
2001
41
Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli. (11466687)
2001
42
Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis. (11241320)
2001
43
Rectal epithelial apoptosis in familial adenomatous polyposis patients treated with sulindac. (10562579)
1999
44
Pineoblastoma presenting in familial adenomatous polyposis (FAP): random association, FAP variant or Turcot syndrome? (10070471)
1998
45
Novel germline mutations in the APC gene and their phenotypic spectrum in familial adenomatous polyposis kindreds. (9341879)
1997
46
Ornithine decarboxylase and polyamines in familial adenomatous polyposis. (9000553)
1997
47
Differences in the levels and pattern of DNA-adduct labelling in human cell lines MCL-5 and CCRF, proficient or deficient in carcinogen-metabolism, treated in vitro with bile from familial adenomatous polyposis patients and from unaffected controls. (8625481)
1996
48
APC mutation analysis by chemical cleavage of mismatch and a protein truncation assay in familial adenomatous polyposis. (7524601)
1994
49
APC mutation associated with late onset of familial adenomatous polyposis. (7853377)
1994
50
Cellular growth response to epidermal growth factor in colon carcinoma cells with an amplified epidermal growth factor receptor derived from a familial adenomatous polyposis patient. (1847663)
1991

Genetic Variations for Familial Adenomatous Polyposis

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Familial Adenomatous Polyposis:

62 (show all 11)
id Symbol AA change Variation ID SNP ID
1APCp.Ser171IleVAR_005032
2APCp.Arg414CysVAR_005033rs137854567
3APCp.Ser784ThrVAR_005034
4APCp.Glu911GlyVAR_005038
5APCp.Pro1176LeuVAR_005044
6APCp.Thr1313AlaVAR_005051
7APCp.Arg1348TrpVAR_005053
8APCp.Ser2621CysVAR_005056rs72541816
9APCp.Leu2839PheVAR_005057
10APCp.Ser722GlyVAR_009614
11APCp.Ala1184ProVAR_009616

Expression for genes affiliated with Familial Adenomatous Polyposis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Adenomatous Polyposis

Search GEO for disease gene expression data for Familial Adenomatous Polyposis.

Pathways for genes affiliated with Familial Adenomatous Polyposis

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29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 59Tocris Bioscience, 12EMD Millipore, 51QIAGEN, 4Cell Signaling Technology, 49PharmGKB, 55SinoBiological, 53Reactome
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Pathways related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9APC, APC2, CTNNB1, AXIN2, WNT2, WNT1
2
Hide members
10.8CSNK1E, APC, APC2, CTNNB1, AXIN2, WNT2
310.8CSNK1E, APC, APC2, CTNNB1, AXIN2, WNT2
4
Hide members
10.8CSNK1E, APC, APC2, CTNNB1, AXIN2, WNT2
5
Hide members
10.8APC, APC2, CTNNB1, AXIN2, MSH6, MSH2
610.8CSNK1E, APC, CTNNB1, WNT2, WNT1, PTGS2
7
Hide members
10.8CSNK1E, APC, CTNNB1, AXIN2, WNT2, WNT1
8
Hide members
10.7WNT1, WNT2, CTNNB1, APC, CSNK1E
910.7KLF4, CSNK1E, APC, CTNNB1, AXIN2
1010.7APC, APC2, CTNNB1, WNT2, WNT1
1110.7PTGER2, MSH6, WNT2, AXIN2, APC
1210.7PTGS2, PTGER2, PLA2G2A, CTNNB1
1310.7CSNK1E, APC, CTNNB1, AXIN2
1410.7APC, CTNNB1, WNT2, WNT1
15
Hide members
10.7APC, CTNNB1, WNT2, WNT1
1610.7APC, CTNNB1, WNT2, WNT1
1710.7WNT1, WNT2, CTNNB1, APC
1810.7KLF4, APC, CTNNB1, AXIN2
19
Hide members
10.7CSNK1E, CTNNB1, WNT2, WNT1
2010.6WNT1, CTNNB1, APC
2110.6WNT1, AXIN2, CTNNB1
22
Transcription Androgen Receptor nuclear signaling
Hide members
10.6WNT1, WNT2, CTNNB1
23
Hide members
10.6OGG1, MUTYH
2410.6ENPP7, SMPD1

Compounds for genes affiliated with Familial Adenomatous Polyposis

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1glycogen44 2412.2AXIN2, CSNK1E, WNT2, PTGER2, CTNNB1, APC
2h2o24411.2SMPD1, NUDT1, MUTYH, CTNNB1, OGG1, ODC1
3adenine44 11 2413.2MSH2, ODC1, OGG1, NUDT1, MUTYH, APC
4serine4411.2CSNK1E, SMPD1, MSH2, PLA2G2A, AXIN2, APC
5threonine4411.2FMO3, APC, CSNK1E, CTNNB1, PTGER2, MSH6
6aspirin44 49 28 2414.2PLA2G2A, PTGER2, APC, CTNNB1, PTGS2, ODC1
7paraffin4411.2MSH2, MSH6, WNT2, CTNNB1, APC, ODC1
8crcs4411.2MSH2, APC, CTNNB1, MSH6, PTGER2
9sulindac44 1112.2PTGS2, CTNNB1, APC, FMO3, ODC1
10dopamine44 28 11 2414.1ODC1, PLA2G2A, APC, CTNNB1, OGG1
118-oxoguanine4411.1NUDT1, MUTYH, APC, OGG1
12methionine4411.1ODC1, APC, NUDT1, SMPD1, FMO3
13samp4411.1CTNNB1, APC, AXIN2
148-oxo-dgtp44 2412.1OGG1, MUTYH, NUDT1
15nmda44 2812.1APC, PTGER2, CTNNB1, PLA2G2A, ODC1
16oligonucleotide4411.1CTNNB1, SMPD1, WNT1, KLF4, APC, OGG1
171,2-dimethylhydrazine4411.1APC, ODC1, CTNNB1
18n-methyl-n-nitrosourea4411.0CTNNB1, MSH6, MSH2
19azoxymethane4411.0CTNNB1, ODC1, APC
20exisulind4411.0CTNNB1, PTGS2, APC
21mononucleotide4411.0MSH2, APC, MSH6
22doxorubicin44 49 1113.0MSH2, SMPD1, MSH6, CTNNB1, ODC1
238-oxo-dg4411.0MUTYH, OGG1, NUDT1
24biotin44 11 2413.0MSH2, MSH6, CTNNB1, KLF4
25phosphorylcholine44 2412.0SMPD1, PLA2G2A, ENPP7
26mnng4411.0SMPD1, MSH2, APC
27pge24411.0SMPD1, PTGS2
28gf 109203x44 5912.0PTGS2, PTGER2, CTNNB1, PLA2G2A
29arachidonic acid44 28 11 2414.0SMPD1, PTGS2, PTGER2, PLA2G2A, CTNNB1
30oxygen44 2412.0OGG1, SMPD1, WNT2, FMO3
31o6-methylguanine4411.0APC, MSH6, MSH2
32af/ap4411.0MUTYH, APC
331-hydroxyanthraquinone4411.0CTNNB1, APC
34methylazoxymethanol acetate4410.9CTNNB1, APC
35pidotimod4410.9CTNNB1, AXIN2
36lysophosphatidylcholine44 2811.9APC, ENPP7, PLA2G2A
37curcumin4410.9PTGS2, APC, CTNNB1, ODC1
38glutamate4410.9WNT1
39ndga4410.9PTGS2, PLA2G2A, ODC1
40prostacyclin4410.9PTGS2, APC, PLA2G2A, PTGER2
41pgd24410.9PTGS2, PTGER2, PLA2G2A
428-hydroxyguanine4410.8MUTYH, OGG1
43ah 68094410.7PTGER2, PTGS2
44cisplatin44 49 59 1113.7CTNNB1, PTGS2, MSH2, MSH6, SMPD1
45prostaglandin4410.7ODC1, PTGER2
46diclofenac44 28 49 1113.7PTGS2, PLA2G2A, CTNNB1
47ah2384844 2811.7PTGER2, PTGS2
48nitric oxide44 11 2412.7KLF4, ODC1, PTGER2, OGG1, SMPD1, PTGS2
49tyrosine4410.6WNT1, SMPD1, PTGER2, ODC1, APC, WNT2
50guanine44 11 2412.5MUTYH

GO Terms for genes affiliated with Familial Adenomatous Polyposis

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16Gene Ontology
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Cellular components related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.6AXIN2, CTNNB1, APC
2catenin complexGO:01634210.6CTNNB1, APC2
3MutSalpha complexGO:03230110.5MSH2, MSH6
4cytoplasmic microtubuleGO:00588110.3APC, APC2, AXIN2

Biological processes related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1DNA repairGO:00628111.2OGG1, CSNK1E, MUTYH, NUDT1, MSH6, MSH2
2negative regulation of cell proliferationGO:00828511.1KLF4, APC, CTNNB1, AXIN2, PTGS2, ENPP7
3canonical Wnt receptor signaling pathwayGO:06007011.0WNT1, WNT2, CTNNB1, APC
4small molecule metabolic processGO:04428111.0ODC1, FMO3, NUDT1, PLA2G2A, PTGS2, ENPP7
5maintenance of DNA repeat elementsGO:04357011.0MSH2, MSH6, AXIN2
6mismatch repairGO:00629811.0MUTYH, MSH6, MSH2
7Wnt receptor signaling pathwayGO:01605511.0APC2, CTNNB1, WNT2, WNT1
8T cell differentiation in thymusGO:03307711.0WNT1, CTNNB1, APC
9canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic processGO:04433610.9WNT1, CTNNB1
10regulation of centromeric sister chromatid cohesionGO:07060210.9CTNNB1, AXIN2
11depurinationGO:04500710.9OGG1, MUTYH
12lung inductionGO:06049210.9CTNNB1, WNT2
13response to estradiol stimulusGO:03235510.9PTGS2, CTNNB1, OGG1
14meiotic mismatch repairGO:00071010.9MSH2, MSH6
15sphingomyelin metabolic processGO:00668410.9SMPD1, ENPP7
16positive regulation of helicase activityGO:05109610.9MSH6, MSH2
17somatic recombination of immunoglobulin gene segmentsGO:01644710.9MSH6, MSH2
18negative regulation of DNA recombinationGO:04591010.8MSH2, MSH6
19base-excision repair, AP site formationGO:00628510.8OGG1, MUTYH
20embryonic axis specificationGO:00057810.8CTNNB1, WNT1
21positive regulation of apoptotic processGO:04306510.8APC, CTNNB1, PTGS2, SMPD1
22negative regulation of catenin import into nucleusGO:03541410.8AXIN2, APC2
23negative regulation of canonical Wnt receptor signaling pathwayGO:09009010.8AXIN2, APC2, APC
24dorsal/ventral axis specificationGO:00995010.7CTNNB1, AXIN2
25response to drugGO:04249310.7OGG1, CTNNB1, PTGS2, SMPD1
26somatic hypermutation of immunoglobulin genesGO:01644610.6MSH2, MSH6
27isotype switchingGO:04519010.6MSH2, MSH6
28response to oxidative stressGO:00697910.5PTGS2, NUDT1, OGG1
29determination of adult lifespanGO:00834010.3MSH2, MSH6

Molecular functions related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.0OGG1, CSNK1E, APC, APC2, CTNNB1, MUTYH
2double-stranded DNA bindingGO:00369011.0MSH2, MSH6, CTNNB1, KLF4
3MutLalpha complex bindingGO:03240510.9MSH2, MSH6, MUTYH
4single thymine insertion bindingGO:03214310.9MSH6, MSH2
5single guanine insertion bindingGO:03214210.8MSH2, MSH6
6oxidized purine DNA bindingGO:03235710.8MSH2, MSH6
7beta-catenin bindingGO:00801310.8AXIN2, APC2, APC
8guanine/thymine mispair bindingGO:03213710.8MSH6, MSH2
9four-way junction DNA bindingGO:00040010.8MSH6, MSH2
10enzyme bindingGO:01989910.8CTNNB1, AXIN2, MSH2, PTGS2
11sphingomyelin phosphodiesterase activityGO:00476710.7ENPP7, SMPD1
12hydrolase activity, acting on glycosyl bondsGO:01679810.7SMPD1, MUTYH
13I-SMAD bindingGO:07041110.6AXIN2, CTNNB1
14mismatched DNA bindingGO:03098310.6MSH2, MSH6
15protein kinase bindingGO:01990110.6APC, CTNNB1, AXIN2, MSH2
16receptor agonist activityGO:04801810.3WNT1, WNT2

Products for genes affiliated with Familial Adenomatous Polyposis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Familial Adenomatous Polyposis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet