FAP
MCID: FML011
MIFTS: 93

Familial Adenomatous Polyposis (FAP) malady

Neuronal diseases, Eye diseases, Gastrointestinal diseases, Skin diseases, Fetal diseases, Cancer diseases, Genetic diseases categories

Summaries for Familial Adenomatous Polyposis

About this section
Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Genetics Home Reference:21 Familial adenomatous polyposis (FAP) is an inherited disorder characterized by cancer of the large intestine (colon) and rectum. People with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) growths (polyps) in the colon as early as their teenage years. Unless the colon is removed, these polyps will become malignant (cancerous). The average age at which an individual develops colon cancer in classic familial adenomatous polyposis is 39 years. Some people have a variant of the disorder, called attenuated familial adenomatous polyposis, in which polyp growth is delayed. The average age of colorectal cancer onset for attenuated familial adenomatous polyposis is 55 years.

MalaCards: Familial Adenomatous Polyposis, also known as adenomatous polyposis coli, is related to adenoma and colorectal cancer, and has symptoms including autosomal dominant inheritance, neoplasms/tumors and colon neoplasm/tumor/carcinoma/cancer. An important gene associated with Familial Adenomatous Polyposis is APC (adenomatous polyposis coli), and among its related pathways are Pathways in cancer and Wnt signaling pathway. The drug celecoxib and the compounds glycogen and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include colon, thyroid and testes, and related mouse phenotypes are cellular and mortality/aging.

Disease Ontology:8 An autosomal dominant disease that is caused by mutations in the apc gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

NIH Rare Diseases:42 Familial adenomatous polyposis (fap) is an inherited colorectal cancer syndrome. cancer usually develops in the lower part of the digestive system, including the large intestine (colon) and rectum. people with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) polyps (growths) in the colon as early as their teenage years. the average age at which an individual develops colon cancer in classic familial adenomatous polyposis is about 39 years. mutations in the apc gene cause classic familial adenomatous polyposis. last updated: 4/6/2010

Wikipedia:63 Familial adenomatous polyposis (FAP) is an inherited condition in which numerous adenomatous polyps form... more...

Description from OMIM:46 608456,175100

Aliases & Classifications for Familial Adenomatous Polyposis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 42NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 48Orphanet, 22GTR, 46OMIM, 60UMLS, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 35MESH via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

48
familial adenomatous polyposis:
Inheritance: Autosomal dominant,Autosomal recessive; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult
attenuated familial adenomatous polyposis:
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Adulthood


Aliases & Descriptions:

familial adenomatous polyposis 8 63 42 20 21 10 44 48
adenomatous polyposis coli 63 42 22 21 46 60
adenomatous polyposis of the colon 8 63 42
fap 63 21 48
familial multiple polyposis 42 22
myh-associated polyposis 21 60
gardner syndrome 48 60
apc-related attenuated familial adenomatous polyposis 48
apc-related attenuated familial polyposis coli 48
familial adenomatous polyposis of the colon 42
familial adenomatous polyposis, attenuated 60
attenuated familial adenomatous polyposis 48
adenomatous familial polyposis syndrome 21
familial multiple polyposis syndrome 21
attenuated familial polyposis coli 48
colorectal adenomatous polyposis 48
adenomatous familial polyposis 21
turcot syndrome with polyposis 48
familial intestinal polyposis 42
apc-related attenuated fap 48
atrial premature complexes 60
hereditary polyposis coli 63
familial polyposis coli 48
colon cancer, familial 63
apc-related afap 48
polyposis coli 63
attenuated fap 48
afap 48


External Ids:

Disease Ontology8 DOID:0050424
MeSH34 D011125
ICD10 via Orphanet26 D12.6
SNOMED-CT via Orphanet57 72900001, 70921007, 60876000
MESH via Orphanet35 C538265, D005736
UMLS via Orphanet61 C2674616, C0017097

Related Diseases for Familial Adenomatous Polyposis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Familial Adenomatous Polyposis family:

Familial Adenomatous Polyposis Due to 5q22.2 Microdeletion

Diseases related to Familial Adenomatous Polyposis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.6SMPD1, ENPP7, PTGS2, PTGER2, MSH2, MSH6
2colorectal cancer31.3ODC1, OGG1, APC, CTNNB1, MUTYH, MSH6
3adenocarcinoma31.2ODC1, KLF4, OGG1, APC, CTNNB1, PLA2G2A
4hepatoblastoma31.0APC, CTNNB1, AXIN2
5breast cancer30.9ODC1, CTNNB1, WNT1, MSH6, MSH2
6colon cancer30.9ODC1, APC, CTNNB1, AXIN2, MSH6, MSH2
7thyroid cancer30.9APC
8lynch syndrome30.9MSH2, MSH6
9pancreatitis30.8PLA2G2A
10squamous cell carcinoma30.8ODC1, KLF4, OGG1, APC, CTNNB1, WNT1
11lung cancer30.7PTGS2, PTGER2, OGG1, ODC1
12hepatocellular carcinoma30.7OGG1, APC, CTNNB1, MUTYH, WNT1, PTGS2
13desmoid tumor30.6APC, CTNNB1
14juvenile polyposis syndrome30.5APC
15gastric adenocarcinoma30.5ODC1, KLF4, APC, CTNNB1, PTGS2
16peutz-jeghers syndrome30.5CTNNB1, APC
17sarcoma30.5ODC1, WNT1, MSH2
18pancreatic cancer30.4KLF4, CTNNB1, WNT1, PLA2G2A, MSH2, PTGS2
19non-small cell lung carcinoma30.4ODC1, OGG1, APC, CTNNB1, WNT2, PTGS2
20melanoma30.3ODC1, CTNNB1, WNT2, PLA2G2A, MSH2
21medulloblastoma30.3APC, CTNNB1
22schizophrenia30.3PLA2G2A, ODC1
23stomach cancer30.3ODC1, APC, CTNNB1, PTGS2
24leukemia30.3ODC1, KLF4, OGG1, NUDT1, PLA2G2A, MSH2
25ovarian cancer30.2OGG1, CTNNB1, MSH6, MSH2
26muir-torre syndrome30.2MSH2, MSH6
27barrett's esophagus30.2PTGS2, APC, ODC1
28gardner syndrome30.2APC, CTNNB1
29turcot syndrome30.2MSH6, MSH2
30gastric cancer, somatic30.2APC, MUTYH
31rheumatoid arthritis30.1PLA2G2A, PTGS2
32arthritis30.1PTGS2, PLA2G2A
33astrocytoma30.1MSH2, PLA2G2A
34meningioma30.0ODC1
35ischemia30.0PLA2G2A
36fibromatosis30.0CTNNB1, APC
37prostate cancer30.0ODC1, CTNNB1, WNT2, WNT1
38duodenitis11.0
39thyroiditis10.8
40ulcerative colitis10.8
41attenuated familial adenomatous polyposis10.7
42papillary carcinoma10.7
43papillary thyroid carcinoma10.7
44polyneuropathy10.5
45neuronitis10.5
46cribriform carcinoma10.5
47nasopharyngitis10.5
48gastroduodenitis10.5
49mutyh-associated polyposis10.5
50familial adenomatous polyposis due to 5q22.2 microdeletion10.5

Graphical network of the top 20 diseases related to Familial Adenomatous Polyposis:



Diseases related to familial adenomatous polyposis

Clinical Features for Familial Adenomatous Polyposis

About this section
Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

608456,175100

Clinical synopsis from OMIM:

175100

Symptoms:

48 (show all 12)
  • autosomal dominant inheritance
  • neoplasms/tumors
  • colon neoplasm/tumor/carcinoma/cancer
  • supernumerary teeth/polyodontia
  • delayed dentition/eruption of teeth/lack of eruption of teeth
  • dental cysts/tumors
  • irregular/in bands/reticular skin hyperpigmentation
  • xanthomas/lipomas
  • fibromatosis/bone fibroma
  • sarcoma
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • polyposis of the bowel/colon/intestine

Drugs & Therapeutics for Familial Adenomatous Polyposis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Familial Adenomatous Polyposis

Drug clinical trials:

Search ClinicalTrials for Familial Adenomatous Polyposis

Search NIH Clinical Center for Familial Adenomatous Polyposis

Search CenterWatch for Familial Adenomatous Polyposis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Familial Adenomatous Polyposis

About this section
Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Familial Adenomatous Polyposis:

id Genetic test Affiliating Genes
1 Familial Adenomatous Polyposis20
2 Adenomatous Polyposis Coli22
3 Familial Multiple Polyposis Syndrome22

Anatomical Context for Familial Adenomatous Polyposis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Familial Adenomatous Polyposis:

32
Colon, Thyroid, Testes, Skin, Pancreas, Bone, Eye, Small intestine, Lung, Brain, Kidney, Liver, Testis, Spleen, T cells

Animal Models for Familial Adenomatous Polyposis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Familial Adenomatous Polyposis:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.4CTNNB1, APC2, APC, OGG1, KLF4, ODC1
2MP:001076811.4MUTYH, CTNNB1, APC, OGG1, KLF4, ODC1
3MP:000200611.3ENPP7, KLF4, OGG1, APC, CTNNB1, MUTYH
4MP:000363111.2OGG1, APC, APC2, CTNNB1, MUTYH, NUDT1
5MP:000538611.1KLF4, OGG1, CSNK1E, APC, APC2, CTNNB1
6MP:000539711.0OGG1, APC, CTNNB1, NUDT1, WNT1, MSH2
7MP:000537611.0KLF4, MUTYH, WNT2, MSH6, PTGER2, ENPP7
8MP:000538710.9OGG1, APC, CTNNB1, NUDT1, WNT1, MSH2
9MP:000538010.8APC, CTNNB1, AXIN2, WNT2, WNT1, PTGS2
10MP:000538910.8KLF4, APC, APC2, CTNNB1, PTGS2
11MP:000537910.5KLF4, AXIN2, ENPP7
12MP:001077110.4PTGS2, PTGER2, CTNNB1, APC

Publications for Familial Adenomatous Polyposis

About this section
Sources:
50PubMed
See all sources

Articles related to Familial Adenomatous Polyposis:

(show top 50)    (show all 752)
idTitleAuthorsYear
1
Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling. (24015932)
2013
2
Prospective enteroscopic evaluation of jejunal polyposis in patients with familial adenomatous polyposis and advanced duodenal polyposis. (23054214)
2013
3
Thyroid cancer complicating familial adenomatous polyposis: mutation spectrum of at-risk individuals. (24093640)
2013
4
Systematic review of the impact of registration and screening on colorectal cancer incidence and mortality in familial adenomatous polyposis and Lynch syndrome. (24227356)
2013
5
EviendepAr reduces number and size of duodenal polyps in familial adenomatous polyposis patients with ileal pouch-anal anastomosis. (24039360)
2013
6
Hepatocellular adenoma associated with familial adenomatous polyposis coli. (23293720)
2012
7
Familial adenomatous polyposis: challenges and pitfalls of surgical treatment. (23730222)
2012
8
Endoluminal ultrasound of neoduodenum following pancreas-preserving total duodenectomy for familial adenomatous polyposis. (22233958)
2012
9
Long-term survival in a case of malignant familial adenomatous polyposis coli with metachronous liver, lung and brain metastases. (21689316)
2012
10
Familial adenomatous polyposis associated with gastrointestinal stromal tumor: report of a case. (22798117)
2012
11
Clinical and genetic characterization of classical forms of familial adenomatous polyposis: a Spanish population study. (20924072)
2011
12
Pancreaticoduodenectomy for advanced duodenal and ampullary adenomatosis in familial adenomatous polyposis. (21492334)
2011
13
First large rearrangement in the MUTYH gene and attenuated familial adenomatous polyposis syndrome. (21815886)
2011
14
A new phenotypic manifestation of familial adenomatous polyposis. (21547505)
2011
15
Familial adenomatous polyposis and desmoid tumors. (22012061)
2011
16
Quality of life after restorative proctocolectomy and ileal pouch-anal anastomosis in patients with familial adenomatous polyposis: a matter of adjustment. (21801297)
2011
17
APC mutations are associated with increased bone mineral density in patients with familial adenomatous polyposis. (20564245)
2010
18
Activation of signal transducer and activator of transcription-1 (STAT-1) and differential expression of interferon-gamma and anti-inflammatory proteins in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis. (20345984)
2010
19
Detection of APC gene germline mutation in Chinese familial adenomatous polyposis by direct sequencing in combination with multiplex ligation-dependent probe amplification]. (20367965)
2010
20
The role of pediatricians in families with a history of familial adenomatous polyposis. (19336753)
2009
21
Small-intestinal involvement in familial adenomatous polyposis: evaluation by double-balloon endoscopy and intraoperative enteroscopy. (18561922)
2008
22
Wnt pathway, angiogenetic and hormonal markers in sporadic and familial adenomatous polyposis-associated juvenile nasopharyngeal angiofibromas (JNA). (18227724)
2008
23
Dentistry anomalies in patients with Lynch syndrome and familial adenomatous polyposis]. (19127816)
2008
24
Combination chemoprevention of intestinal carcinogenesis in a murine model of familial adenomatous polyposis. (19003578)
2008
25
Detection of adenomatous polyposis coli gene mutations in 31 familial adenomatous polyposis families by using denaturing high performance liquid chromatography]. (18393237)
2008
26
Clinical characterization and the mutation spectrum in Swedish adenomatous polyposis families. (18433509)
2008
27
Capsule endoscopy is useful and safe for small-bowel surveillance in familial adenomatous polyposis. (18155426)
2008
28
Deletion mutation of BRAF in a serrated adenoma from a patient with familial adenomatous polyposis. (17696956)
2007
29
Brain tumors in individuals with familial adenomatous polyposis: a cancer registry experience and pooled case report analysis. (17238184)
2007
30
Familial adenomatous polyposis. (17706519)
2007
31
The impact of technical factors on outcome of restorative proctocolectomy for familial adenomatous polyposis. (17464542)
2007
32
Meta-analysis of observational studies of ileorectal versus ileal pouch-anal anastomosis for familial adenomatous polyposis. (16511903)
2006
33
Ileostomy carcinomas a review: the latent risk after colectomy for ulcerative colitis and familial adenomatous polyposis: H. M. Quah, A. Samad and A. Maw. (16784479)
2006
34
APC germ-line mutations in southern Spanish patients with familial adenomatous polyposis: genotype-phenotype correlations and identification of eight novel mutations. (15857185)
2005
35
An unexpected Cowden syndrome case found among members of a large familial adenomatous polyposis kindred. (16292097)
2005
36
Alteration of O6-methylguanine-DNA methyltransferase in colorectal neoplasms in sporadic and familial adenomatous polyposis patients. (12720298)
2003
37
A randomized, double-blind, placebo-controlled trial of the effects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on rectal polyps in familial adenomatous polyposis patients. (14581346)
2003
38
Expression of COX-2 and Wnt pathway genes in adenomas of familial adenomatous polyposis patients treated with meloxicam. (12174906)
2002
39
The influence of mutation site and age on the severity of duodenal polyposis in patients with familial adenomatous polyposis. (11868006)
2002
40
Celecoxib: a new option in the treatment of arthropathies and familial adenomatous polyposis. (11336575)
2001
41
Effect of celecoxib, a COX-2 inhibitor, in familial adenomatous polyposis]. (11367984)
2001
42
Cribriform-morular variant of papillary carcinoma: a distinctive variant representing the sporadic counterpart of familial adenomatous polyposis-associated thyroid carcinoma? (10229505)
1999
43
The ret/ptc1 oncogene is activated in familial adenomatous polyposis-associated thyroid papillary carcinomas. (9506763)
1998
44
Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. (9378405)
1997
45
Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. (9038672)
1996
46
Variants at the secretory phospholipase A2 (PLA2G2A) locus: analysis of associations with familial adenomatous polyposis and sporadic colorectal tumours. (8912789)
1996
47
Attenuated familial adenomatous polyposis (AFAP). A phenotypically and genotypically distinctive variant of FAP. (8625067)
1995
48
Identification of germ line mutation of APC gene in possible carriers of familial adenomatous polyposis (FAP). (7840521)
1994
49
Facioscapulohumeral muscular dystrophy gene in Dutch families is not linked to markers for familial adenomatous polyposis on the long arm of chromosome 5. (2157824)
1990
50
Familial colorectal cancer and familial adenomatous polyposis. (2558747)
1989

Genetic Variations for Familial Adenomatous Polyposis

About this section
Sources:
62UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Familial Adenomatous Polyposis:

62 (show all 11)
id Symbol AA change Variation ID SNP ID
1APCp.Ser171IleVAR_005032
2APCp.Arg414CysVAR_005033rs137854567
3APCp.Ser784ThrVAR_005034
4APCp.Glu911GlyVAR_005038
5APCp.Pro1176LeuVAR_005044
6APCp.Thr1313AlaVAR_005051
7APCp.Arg1348TrpVAR_005053
8APCp.Ser2621CysVAR_005056rs72541816
9APCp.Leu2839PheVAR_005057
10APCp.Ser722GlyVAR_009614
11APCp.Ala1184ProVAR_009616

Expression for genes affiliated with Familial Adenomatous Polyposis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Familial Adenomatous Polyposis

Search GEO for disease gene expression data for Familial Adenomatous Polyposis.

Pathways for genes affiliated with Familial Adenomatous Polyposis

About this section
Sources:
29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 59Tocris Bioscience, 12EMD Millipore, 51QIAGEN, 4Cell Signaling Technology, 49PharmGKB, 55SinoBiological, 53Reactome
See all sources

Pathways related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9APC, APC2, CTNNB1, AXIN2, WNT2, WNT1
2
Hide members
10.8CSNK1E, APC, APC2, CTNNB1, AXIN2, WNT2
310.8CSNK1E, APC, APC2, CTNNB1, AXIN2, WNT2
4
Hide members
10.8CSNK1E, APC, APC2, CTNNB1, AXIN2, WNT2
5
Hide members
10.8APC, APC2, CTNNB1, AXIN2, MSH6, MSH2
610.8CSNK1E, APC, CTNNB1, WNT2, WNT1, PTGS2
7
Hide members
10.8CSNK1E, APC, CTNNB1, AXIN2, WNT2, WNT1
8
Hide members
10.7WNT1, WNT2, CTNNB1, APC, CSNK1E
910.7KLF4, CSNK1E, APC, CTNNB1, AXIN2
1010.7APC, APC2, CTNNB1, WNT2, WNT1
1110.7PTGER2, MSH6, WNT2, AXIN2, APC
1210.7PTGS2, PTGER2, PLA2G2A, CTNNB1
1310.7CSNK1E, APC, CTNNB1, AXIN2
1410.7APC, CTNNB1, WNT2, WNT1
15
Hide members
10.7APC, CTNNB1, WNT2, WNT1
1610.7APC, CTNNB1, WNT2, WNT1
1710.7WNT1, WNT2, CTNNB1, APC
1810.7KLF4, APC, CTNNB1, AXIN2
19
Hide members
10.7CSNK1E, CTNNB1, WNT2, WNT1
2010.6WNT1, CTNNB1, APC
2110.6WNT1, AXIN2, CTNNB1
22
Transcription Androgen Receptor nuclear signaling
Hide members
10.6WNT1, WNT2, CTNNB1
23
Hide members
10.6OGG1, MUTYH
2410.6ENPP7, SMPD1

Compounds for genes affiliated with Familial Adenomatous Polyposis

About this section
Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
See all sources

Compounds related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1glycogen44 2412.2CSNK1E, APC, CTNNB1, AXIN2, WNT2, WNT1
2h2o24411.2ODC1, OGG1, CTNNB1, MUTYH, NUDT1, PLA2G2A
3adenine44 11 2413.2ODC1, OGG1, APC, MUTYH, NUDT1, MSH2
4serine4411.2CSNK1E, APC, AXIN2, PLA2G2A, MSH2, SMPD1
5threonine4411.2FMO3, CSNK1E, APC, CTNNB1, AXIN2, MSH6
6aspirin44 49 28 2414.2ODC1, APC, CTNNB1, PLA2G2A, PTGER2, PTGS2
7paraffin4411.2ODC1, APC, CTNNB1, WNT2, MSH6, MSH2
8crcs4411.2PTGER2, MSH2, MSH6, CTNNB1, APC
9sulindac44 1112.2ODC1, FMO3, APC, CTNNB1, PTGS2
10dopamine44 28 11 2414.1ODC1, OGG1, APC, CTNNB1, PLA2G2A
118-oxoguanine4411.1OGG1, APC, MUTYH, NUDT1
12methionine4411.1ODC1, FMO3, APC, NUDT1, SMPD1
13samp4411.1AXIN2, CTNNB1, APC
148-oxo-dgtp44 2412.1NUDT1, MUTYH, OGG1
15nmda44 2812.1ODC1, APC, CTNNB1, PLA2G2A, PTGER2
16oligonucleotide4411.1KLF4, OGG1, APC, CTNNB1, WNT1, SMPD1
171,2-dimethylhydrazine4411.1CTNNB1, APC, ODC1
18n-methyl-n-nitrosourea4411.0CTNNB1, MSH6, MSH2
19azoxymethane4411.0ODC1, APC, CTNNB1
20exisulind4411.0APC, CTNNB1, PTGS2
21mononucleotide4411.0MSH2, MSH6, APC
22doxorubicin44 49 1113.0ODC1, CTNNB1, MSH6, MSH2, SMPD1
23biotin44 11 2413.0MSH2, MSH6, CTNNB1, KLF4
24mnng4411.0APC, MSH2, SMPD1
25phosphorylcholine44 2412.0SMPD1, ENPP7, PLA2G2A
268-oxo-dg4411.0OGG1, MUTYH, NUDT1
27pge24411.0PTGS2, SMPD1
28gf 109203x44 5912.0CTNNB1, PLA2G2A, PTGER2, PTGS2
29arachidonic acid44 28 11 2414.0CTNNB1, PLA2G2A, PTGER2, PTGS2, SMPD1
30oxygen44 2412.0FMO3, OGG1, WNT2, SMPD1
31o6-methylguanine4411.0MSH2, MSH6, APC
32methylazoxymethanol acetate4411.0APC, CTNNB1
331-hydroxyanthraquinone4411.0APC, CTNNB1
34af/ap4410.9APC, MUTYH
35pidotimod4410.9CTNNB1, AXIN2
36lysophosphatidylcholine44 2811.9ENPP7, PLA2G2A, APC
37curcumin4410.9ODC1, APC, CTNNB1, PTGS2
38glutamate4410.9WNT1
39ndga4410.9ODC1, PLA2G2A, PTGS2
40prostacyclin4410.9APC, PLA2G2A, PTGER2, PTGS2
41pgd24410.9PLA2G2A, PTGER2, PTGS2
428-hydroxyguanine4410.8OGG1, MUTYH
43ah 68094410.7PTGER2, PTGS2
44cisplatin44 49 59 1113.7SMPD1, PTGS2, MSH2, MSH6, CTNNB1
45prostaglandin4410.7PTGER2, ODC1
46diclofenac44 28 49 1113.7CTNNB1, PLA2G2A, PTGS2
47ah2384844 2811.7PTGS2, PTGER2
48nitric oxide44 11 2412.7ODC1, KLF4, OGG1, PTGER2, PTGS2, SMPD1
49tyrosine4410.6ODC1, APC, CTNNB1, WNT2, WNT1, MSH6
50guanine44 11 2412.5MUTYH

GO Terms for genes affiliated with Familial Adenomatous Polyposis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.6AXIN2, CTNNB1, APC
2catenin complexGO:01634210.6CTNNB1, APC2
3MutSalpha complexGO:03230110.5MSH2, MSH6
4cytoplasmic microtubuleGO:00588110.3APC, APC2, AXIN2

Biological processes related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1DNA repairGO:00628111.2OGG1, CSNK1E, MUTYH, NUDT1, MSH6, MSH2
2negative regulation of cell proliferationGO:00828511.1KLF4, APC, CTNNB1, AXIN2, PTGS2, ENPP7
3canonical Wnt receptor signaling pathwayGO:06007011.0WNT1, WNT2, CTNNB1, APC
4small molecule metabolic processGO:04428111.0ODC1, FMO3, NUDT1, PLA2G2A, PTGS2, ENPP7
5maintenance of DNA repeat elementsGO:04357011.0MSH2, MSH6, AXIN2
6mismatch repairGO:00629811.0MUTYH, MSH6, MSH2
7Wnt receptor signaling pathwayGO:01605511.0APC2, CTNNB1, WNT2, WNT1
8T cell differentiation in thymusGO:03307711.0WNT1, CTNNB1, APC
9canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic processGO:04433610.9WNT1, CTNNB1
10regulation of centromeric sister chromatid cohesionGO:07060210.9CTNNB1, AXIN2
11depurinationGO:04500710.9OGG1, MUTYH
12lung inductionGO:06049210.9CTNNB1, WNT2
13response to estradiol stimulusGO:03235510.9PTGS2, CTNNB1, OGG1
14meiotic mismatch repairGO:00071010.9MSH2, MSH6
15sphingomyelin metabolic processGO:00668410.9SMPD1, ENPP7
16positive regulation of helicase activityGO:05109610.9MSH6, MSH2
17somatic recombination of immunoglobulin gene segmentsGO:01644710.9MSH6, MSH2
18negative regulation of DNA recombinationGO:04591010.8MSH2, MSH6
19base-excision repair, AP site formationGO:00628510.8OGG1, MUTYH
20embryonic axis specificationGO:00057810.8CTNNB1, WNT1
21positive regulation of apoptotic processGO:04306510.8APC, CTNNB1, PTGS2, SMPD1
22negative regulation of catenin import into nucleusGO:03541410.8AXIN2, APC2
23negative regulation of canonical Wnt receptor signaling pathwayGO:09009010.8AXIN2, APC2, APC
24dorsal/ventral axis specificationGO:00995010.7CTNNB1, AXIN2
25response to drugGO:04249310.7OGG1, CTNNB1, PTGS2, SMPD1
26somatic hypermutation of immunoglobulin genesGO:01644610.6MSH2, MSH6
27isotype switchingGO:04519010.6MSH2, MSH6
28response to oxidative stressGO:00697910.5PTGS2, NUDT1, OGG1
29determination of adult lifespanGO:00834010.3MSH2, MSH6

Molecular functions related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.0OGG1, CSNK1E, APC, APC2, CTNNB1, MUTYH
2double-stranded DNA bindingGO:00369011.0MSH2, MSH6, CTNNB1, KLF4
3MutLalpha complex bindingGO:03240510.9MSH2, MSH6, MUTYH
4single thymine insertion bindingGO:03214310.9MSH6, MSH2
5single guanine insertion bindingGO:03214210.8MSH2, MSH6
6oxidized purine DNA bindingGO:03235710.8MSH2, MSH6
7beta-catenin bindingGO:00801310.8AXIN2, APC2, APC
8guanine/thymine mispair bindingGO:03213710.8MSH6, MSH2
9four-way junction DNA bindingGO:00040010.8MSH6, MSH2
10enzyme bindingGO:01989910.8CTNNB1, AXIN2, MSH2, PTGS2
11sphingomyelin phosphodiesterase activityGO:00476710.7ENPP7, SMPD1
12hydrolase activity, acting on glycosyl bondsGO:01679810.7SMPD1, MUTYH
13I-SMAD bindingGO:07041110.6AXIN2, CTNNB1
14mismatched DNA bindingGO:03098310.6MSH2, MSH6
15protein kinase bindingGO:01990110.6APC, CTNNB1, AXIN2, MSH2
16receptor agonist activityGO:04801810.3WNT1, WNT2

Products for genes affiliated with Familial Adenomatous Polyposis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Familial Adenomatous Polyposis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet