FAP
MCID: FML011
MIFTS: 93

Familial Adenomatous Polyposis (FAP) malady

Neuronal diseases, Eye diseases, Gastrointestinal diseases, Skin diseases, Fetal diseases, Cancer diseases, Genetic diseases categories

Summaries for Familial Adenomatous Polyposis

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8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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Genetics Home Reference:21 Familial adenomatous polyposis (FAP) is an inherited disorder characterized by cancer of the large intestine (colon) and rectum. People with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) growths (polyps) in the colon as early as their teenage years. Unless the colon is removed, these polyps will become malignant (cancerous). The average age at which an individual develops colon cancer in classic familial adenomatous polyposis is 39 years. Some people have a variant of the disorder, called attenuated familial adenomatous polyposis, in which polyp growth is delayed. The average age of colorectal cancer onset for attenuated familial adenomatous polyposis is 55 years.

MalaCards: Familial Adenomatous Polyposis, also known as adenomatous polyposis coli, is related to adenoma and colorectal cancer, and has symptoms including autosomal dominant inheritance, neoplasms/tumors and colon neoplasm/tumor/carcinoma/cancer. An important gene associated with Familial Adenomatous Polyposis is APC (adenomatous polyposis coli), and among its related pathways are Pathways in cancer and Wnt signaling pathway. The drug celecoxib and the compounds glycogen and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include colon, thyroid and testes, and related mouse phenotypes are cellular and mortality/aging.

Disease Ontology:8 An autosomal dominant disease that is caused by mutations in the apc gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

NIH Rare Diseases:42 Familial adenomatous polyposis (fap) is an inherited colorectal cancer syndrome. cancer usually develops in the lower part of the digestive system, including the large intestine (colon) and rectum. people with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) polyps (growths) in the colon as early as their teenage years. the average age at which an individual develops colon cancer in classic familial adenomatous polyposis is about 39 years. mutations in the apc gene cause classic familial adenomatous polyposis. last updated: 4/6/2010

Wikipedia:63 Familial adenomatous polyposis (FAP) is an inherited condition in which numerous adenomatous polyps form... more...

Description from OMIM:46 608456,175100

Aliases & Classifications for Familial Adenomatous Polyposis

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8Disease Ontology, 63Wikipedia, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 35MESH via Orphanet, 61UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
familial adenomatous polyposis:
Inheritance: Autosomal dominant,Autosomal recessive; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult
attenuated familial adenomatous polyposis:
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Adulthood


Aliases & Descriptions:

familial adenomatous polyposis 8 63 42 20 21 10 44 48
adenomatous polyposis coli 63 42 22 21 46 60
adenomatous polyposis of the colon 8 63 42
fap 63 21 48
familial multiple polyposis 42 22
myh-associated polyposis 21 60
gardner syndrome 48 60
apc-related attenuated familial adenomatous polyposis 48
apc-related attenuated familial polyposis coli 48
familial adenomatous polyposis of the colon 42
familial adenomatous polyposis, attenuated 60
attenuated familial adenomatous polyposis 48
adenomatous familial polyposis syndrome 21
familial multiple polyposis syndrome 21
attenuated familial polyposis coli 48
colorectal adenomatous polyposis 48
adenomatous familial polyposis 21
turcot syndrome with polyposis 48
familial intestinal polyposis 42
apc-related attenuated fap 48
atrial premature complexes 60
hereditary polyposis coli 63
familial polyposis coli 48
colon cancer, familial 63
apc-related afap 48
attenuated fap 48
polyposis coli 63
afap 48


External Ids:

Disease Ontology8 DOID:0050424
MeSH34 D011125
ICD10 via Orphanet26 D12.6
SNOMED-CT via Orphanet57 72900001, 70921007, 60876000
MESH via Orphanet35 C538265, D005736
UMLS via Orphanet61 C2674616, C0017097

Related Diseases for Familial Adenomatous Polyposis

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17GeneCards, 18GeneDecks
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Diseases in the Familial Adenomatous Polyposis family:

Familial Adenomatous Polyposis Due to 5q22.2 Microdeletion

Diseases related to Familial Adenomatous Polyposis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.6SMPD1, ENPP7, PTGS2, PTGER2, MSH2, MSH6
2colorectal cancer31.3ODC1, OGG1, APC, CTNNB1, MUTYH, MSH6
3adenocarcinoma31.2ODC1, KLF4, OGG1, APC, CTNNB1, PLA2G2A
4hepatoblastoma31.0APC, CTNNB1, AXIN2
5breast cancer30.9ODC1, CTNNB1, WNT1, MSH6, MSH2
6colon cancer30.9ODC1, APC, CTNNB1, AXIN2, MSH6, MSH2
7thyroid cancer30.9APC
8lynch syndrome30.9MSH2, MSH6
9pancreatitis30.8PLA2G2A
10squamous cell carcinoma30.8ODC1, KLF4, OGG1, APC, CTNNB1, WNT1
11lung cancer30.7PTGS2, PTGER2, OGG1, ODC1
12hepatocellular carcinoma30.7OGG1, APC, CTNNB1, MUTYH, WNT1, PTGS2
13desmoid tumor30.6APC, CTNNB1
14juvenile polyposis syndrome30.5APC
15gastric adenocarcinoma30.5ODC1, KLF4, APC, CTNNB1, PTGS2
16peutz-jeghers syndrome30.5CTNNB1, APC
17sarcoma30.5ODC1, WNT1, MSH2
18pancreatic cancer30.4KLF4, CTNNB1, WNT1, PLA2G2A, MSH2, PTGS2
19non-small cell lung carcinoma30.4ODC1, OGG1, APC, CTNNB1, WNT2, PTGS2
20melanoma30.3ODC1, CTNNB1, WNT2, PLA2G2A, MSH2
21medulloblastoma30.3APC, CTNNB1
22schizophrenia30.3PLA2G2A, ODC1
23stomach cancer30.3ODC1, APC, CTNNB1, PTGS2
24leukemia30.3ODC1, KLF4, OGG1, NUDT1, PLA2G2A, MSH2
25ovarian cancer30.2OGG1, CTNNB1, MSH6, MSH2
26muir-torre syndrome30.2MSH2, MSH6
27barrett's esophagus30.2PTGS2, APC, ODC1
28gardner syndrome30.2APC, CTNNB1
29turcot syndrome30.2MSH6, MSH2
30gastric cancer, somatic30.2APC, MUTYH
31rheumatoid arthritis30.1PLA2G2A, PTGS2
32arthritis30.1PTGS2, PLA2G2A
33astrocytoma30.1MSH2, PLA2G2A
34meningioma30.0ODC1
35ischemia30.0PLA2G2A
36fibromatosis30.0CTNNB1, APC
37prostate cancer30.0ODC1, CTNNB1, WNT2, WNT1
38duodenitis11.0
39thyroiditis10.8
40ulcerative colitis10.8
41attenuated familial adenomatous polyposis10.7
42papillary carcinoma10.7
43papillary thyroid carcinoma10.7
44polyneuropathy10.5
45neuronitis10.5
46cribriform carcinoma10.5
47nasopharyngitis10.5
48gastroduodenitis10.5
49mutyh-associated polyposis10.5
50familial adenomatous polyposis due to 5q22.2 microdeletion10.5

Graphical network of the top 20 diseases related to Familial Adenomatous Polyposis:



Diseases related to familial adenomatous polyposis

Clinical Features for Familial Adenomatous Polyposis

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46OMIM, 48Orphanet
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Clinical features from OMIM:

608456,175100

Clinical synopsis from OMIM:

175100

Symptoms:

48 (show all 12)
  • autosomal dominant inheritance
  • neoplasms/tumors
  • colon neoplasm/tumor/carcinoma/cancer
  • supernumerary teeth/polyodontia
  • delayed dentition/eruption of teeth/lack of eruption of teeth
  • dental cysts/tumors
  • irregular/in bands/reticular skin hyperpigmentation
  • xanthomas/lipomas
  • fibromatosis/bone fibroma
  • sarcoma
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • polyposis of the bowel/colon/intestine

Drugs & Therapeutics for Familial Adenomatous Polyposis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Familial Adenomatous Polyposis

Drug clinical trials:

Search ClinicalTrials for Familial Adenomatous Polyposis

Search NIH Clinical Center for Familial Adenomatous Polyposis

Search CenterWatch for Familial Adenomatous Polyposis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Familial Adenomatous Polyposis

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20GeneTests, 22GTR
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Genetic tests related to Familial Adenomatous Polyposis:

id Genetic test Affiliating Genes
1 Familial Adenomatous Polyposis20
2 Adenomatous Polyposis Coli22
3 Familial Multiple Polyposis Syndrome22

Anatomical Context for Familial Adenomatous Polyposis

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32MalaCards
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MalaCards organs/tissues related to Familial Adenomatous Polyposis:

32
Colon, Thyroid, Testes, Skin, Pancreas, Bone, Eye, Small intestine, Lung, Brain, Kidney, Liver, Testis, Spleen, T cells

Animal Models for Familial Adenomatous Polyposis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Familial Adenomatous Polyposis:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.4CTNNB1, APC2, APC, OGG1, KLF4, ODC1
2MP:001076811.4MUTYH, CTNNB1, APC, OGG1, KLF4, ODC1
3MP:000200611.3ENPP7, KLF4, OGG1, APC, CTNNB1, MUTYH
4MP:000363111.2OGG1, APC, APC2, CTNNB1, MUTYH, NUDT1
5MP:000538611.1KLF4, OGG1, CSNK1E, APC, APC2, CTNNB1
6MP:000539711.0OGG1, APC, CTNNB1, NUDT1, WNT1, MSH2
7MP:000537611.0KLF4, MUTYH, WNT2, MSH6, PTGER2, ENPP7
8MP:000538710.9OGG1, APC, CTNNB1, NUDT1, WNT1, MSH2
9MP:000538010.8APC, CTNNB1, AXIN2, WNT2, WNT1, PTGS2
10MP:000538910.8KLF4, APC, APC2, CTNNB1, PTGS2
11MP:000537910.5KLF4, AXIN2, ENPP7
12MP:001077110.4PTGS2, PTGER2, CTNNB1, APC

Publications for Familial Adenomatous Polyposis

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50PubMed
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Articles related to Familial Adenomatous Polyposis:

(show top 50)    (show all 752)
idTitleAuthorsYear
1
APC germline mutations in families with familial adenomatous polyposis. (23970361)
2013
2
Severe duodenal involvement in familial adenomatous polyposis treated by pylorus-preserving pancreaticoduodenectomy. (22311120)
2012
3
Surgical treatment of familial adenomatous polyposis: experience from a single institution in China. (22897208)
2012
4
Can combined 18F-FDG-PET and dynamic contrast-enhanced MRI predict behavior of desmoid tumors in patients with familial adenomatous polyposis? (22965401)
2012
5
Bilateral Sertoli cell tumors of the testis-a likely new extracolonic manifestation of familial adenomatous polyposis. (23090627)
2012
6
An AT-rich region in the APC gene may cause misinterpretation of familial adenomatous polyposis molecular screening. (22447671)
2012
7
Comprehensive analysis of the bacterial content of stool from patients with chronic pouchitis, normal pouches, or familial adenomatous polyposis pouches. (22114001)
2012
8
Desmoid Tumor Associated With Familial Adenomatous Polyposis: Evaluation With 64-Detector CT Enterography. (23329958)
2012
9
Hepatocelluar carcinoma associated with attenuated familial adenomatous polyposis: a case report and review of the literature. (21813337)
2012
10
Familial adenomatous polyposis-rendering a diagnosis based on recognition of an unusual primary thyroid neoplasm. (21423546)
2011
11
Celecoxib in a 12-year-old boy with familial adenomatous polyposis. (20197018)
2010
12
Evaluating causes of death in familial adenomatous polyposis. (20676788)
2010
13
Novel cell culture model for prevention of carcinogenic risk in familial adenomatous polyposis syndrome. (19288003)
2009
14
Papillary thyroid carcinoma and familial adenomatous polyposis of the colon. (19027515)
2009
15
Gardner's syndrome (familial adenomatous polyposis): a cilia-related disorder. (19573802)
2009
16
Familial adenomatous polyposis in children younger than age ten years: a multidisciplinary clinic experience. (18157572)
2008
17
The pancreas in familial adenomatous polyposis. (18182737)
2008
18
Total gastrectomy for gastric dysplasia in a patient with attenuated familial adenomatous polyposis syndrome. (18640943)
2008
19
The management of desmoids in patients with familial adenomatous polyposis (FAP). (19069698)
2008
20
Functional characterization of the novel APC N1026S variant associated with attenuated familial adenomatous polyposis. (18166348)
2008
21
Double balloon endoscopy for detection of small-bowel adenomas in familial adenomatous polyposis after pancreaticoduodenectomy according to Whipple. (18716983)
2008
22
Differential expression of pro-inflammatory cytokines and a pro-apoptotic protein in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis. (18512010)
2008
23
APC gene mutations causing familial adenomatous polyposis in Polish patients. (19029688)
2008
24
Fundic gland polyp dysplasia is common in familial adenomatous polyposis. (18237868)
2008
25
A papillary thyroid carcinoma case associated with hereditary colon carcinoma due to familial adenomatous polyposis with no hereditary mutation finding. (15834731)
2007
26
Heterogeneous molecular mechanisms underlie attenuated familial adenomatous polyposis. (18091433)
2007
27
Population differences in familial adenomatous polyposis may be an expression of geographic differences in APC mutation pattern. (17213033)
2007
28
Hepatocellular adenoma displaying a HNF1alpha inactivation in a patient with familial adenomatous polyposis coli. (17049664)
2006
29
Singapore familial adenomatous polyposis (FAP) patients with classical adenomatous polyposis but undetectable APC mutations have accelerated cancer progression. (17026565)
2006
30
Index case of familial adenomatous polyposis revealed by congenital hypertrophy of the retinal pigment epithelium. (16230738)
2005
31
Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis. (15941485)
2005
32
Development of an intraductal papillary-mucinous neoplasm of the pancreas in a patient with familial adenomatous polyposis. (16258383)
2005
33
Clinical and ethical implications of genetic counselling in familial adenomatous polyposis. (16266238)
2005
34
Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation. (15542524)
2004
35
Identification of genomic deletions of the APC gene in familial adenomatous polyposis by two independent quantitative techniques. (15727247)
2004
36
Attenuated familial adenomatous polyposis (AFAP). A review of the literature. (14574166)
2003
37
Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis. (11588890)
2001
38
Topoisomerase-I- and Alu-mediated genomic deletions of the APC gene in familial adenomatous polyposis. (11409872)
2001
39
Novel germline APC mutations in Swedish patients with familial adenomatous polyposis and Gardner syndrome. (11145293)
2000
40
About a case of familial adenomatous polyposis. (16498338)
1999
41
Hepatocellular carcinoma in children associated with Gardner syndrome or familial adenomatous polyposis. (9628444)
1998
42
Constitutive APC exon 14 skipping in early-onset familial adenomatous polyposis reveals a dramatic quantitative distortion of APC gene-specific isoforms. (9298819)
1997
43
Establishment and characterization of a human colon cancer cell line, OUMS-23, from a patient with familial adenomatous polyposis. (8576285)
1996
44
The clinical [corrected] background of familial adenomatous polyposis. History, epidemiology, diagnosis and treatment. (7571988)
1995
45
Proliferative compartment deregulation in the non-neoplastic colonic epithelium of familial adenomatous polyposis. (7698699)
1995
46
Presymptomatic diagnosis in families with adenomatous polyposis using highly polymorphic dinucleotide CA repeat markers flanking the APC gene. (7915330)
1994
47
Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP). (8395678)
1993
48
Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas. (1355210)
1992
49
Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients. (1319835)
1992
50
Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay. (1970154)
1990

Genetic Variations for Familial Adenomatous Polyposis

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Familial Adenomatous Polyposis:

62 (show all 11)
id Symbol AA change Variation ID SNP ID
1APCp.Ser171IleVAR_005032
2APCp.Arg414CysVAR_005033rs137854567
3APCp.Ser784ThrVAR_005034
4APCp.Glu911GlyVAR_005038
5APCp.Pro1176LeuVAR_005044
6APCp.Thr1313AlaVAR_005051
7APCp.Arg1348TrpVAR_005053
8APCp.Ser2621CysVAR_005056rs72541816
9APCp.Leu2839PheVAR_005057
10APCp.Ser722GlyVAR_009614
11APCp.Ala1184ProVAR_009616

Expression for genes affiliated with Familial Adenomatous Polyposis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Adenomatous Polyposis

Search GEO for disease gene expression data for Familial Adenomatous Polyposis.

Pathways for genes affiliated with Familial Adenomatous Polyposis

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29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 59Tocris Bioscience, 12EMD Millipore, 51QIAGEN, 4Cell Signaling Technology, 49PharmGKB, 55SinoBiological, 53Reactome
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Pathways related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9APC, APC2, CTNNB1, AXIN2, WNT2, WNT1
2
Hide members
10.8CSNK1E, APC, APC2, CTNNB1, AXIN2, WNT2
310.8CSNK1E, APC, APC2, CTNNB1, AXIN2, WNT2
4
Hide members
10.8CSNK1E, APC, APC2, CTNNB1, AXIN2, WNT2
5
Hide members
10.8APC, APC2, CTNNB1, AXIN2, MSH6, MSH2
610.8CSNK1E, APC, CTNNB1, WNT2, WNT1, PTGS2
7
Hide members
10.8CSNK1E, APC, CTNNB1, AXIN2, WNT2, WNT1
8
Hide members
10.7WNT1, WNT2, CTNNB1, APC, CSNK1E
910.7KLF4, CSNK1E, APC, CTNNB1, AXIN2
1010.7APC, APC2, CTNNB1, WNT2, WNT1
1110.7PTGER2, MSH6, WNT2, AXIN2, APC
1210.7PTGS2, PTGER2, PLA2G2A, CTNNB1
1310.7CSNK1E, APC, CTNNB1, AXIN2
1410.7APC, CTNNB1, WNT2, WNT1
15
Hide members
10.7APC, CTNNB1, WNT2, WNT1
1610.7APC, CTNNB1, WNT2, WNT1
1710.7WNT1, WNT2, CTNNB1, APC
1810.7KLF4, APC, CTNNB1, AXIN2
19
Hide members
10.7CSNK1E, CTNNB1, WNT2, WNT1
2010.6WNT1, CTNNB1, APC
2110.6WNT1, AXIN2, CTNNB1
22
Transcription Androgen Receptor nuclear signaling
Hide members
10.6WNT1, WNT2, CTNNB1
23
Hide members
10.6OGG1, MUTYH
2410.6ENPP7, SMPD1

Compounds for genes affiliated with Familial Adenomatous Polyposis

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1glycogen44 2412.2AXIN2, CSNK1E, WNT2, PTGER2, CTNNB1, APC
2h2o24411.2SMPD1, NUDT1, MUTYH, CTNNB1, OGG1, ODC1
3adenine44 11 2413.2MSH2, ODC1, OGG1, NUDT1, MUTYH, APC
4serine4411.2CSNK1E, SMPD1, MSH2, PLA2G2A, AXIN2, APC
5threonine4411.2FMO3, APC, CSNK1E, CTNNB1, PTGER2, MSH6
6aspirin44 49 28 2414.2PLA2G2A, PTGER2, APC, CTNNB1, PTGS2, ODC1
7paraffin4411.2MSH2, MSH6, WNT2, CTNNB1, APC, ODC1
8crcs4411.2MSH2, APC, CTNNB1, MSH6, PTGER2
9sulindac44 1112.2PTGS2, CTNNB1, APC, FMO3, ODC1
10dopamine44 28 11 2414.1ODC1, PLA2G2A, APC, CTNNB1, OGG1
118-oxoguanine4411.1NUDT1, MUTYH, APC, OGG1
12methionine4411.1ODC1, APC, NUDT1, SMPD1, FMO3
13samp4411.1CTNNB1, APC, AXIN2
148-oxo-dgtp44 2412.1OGG1, MUTYH, NUDT1
15nmda44 2812.1APC, PTGER2, CTNNB1, PLA2G2A, ODC1
16oligonucleotide4411.1CTNNB1, SMPD1, WNT1, KLF4, APC, OGG1
171,2-dimethylhydrazine4411.1APC, ODC1, CTNNB1
18n-methyl-n-nitrosourea4411.0CTNNB1, MSH6, MSH2
19azoxymethane4411.0CTNNB1, ODC1, APC
20exisulind4411.0CTNNB1, PTGS2, APC
21mononucleotide4411.0MSH2, APC, MSH6
22doxorubicin44 49 1113.0MSH2, SMPD1, MSH6, CTNNB1, ODC1
238-oxo-dg4411.0MUTYH, OGG1, NUDT1
24biotin44 11 2413.0MSH2, MSH6, CTNNB1, KLF4
25phosphorylcholine44 2412.0SMPD1, PLA2G2A, ENPP7
26mnng4411.0SMPD1, MSH2, APC
27pge24411.0SMPD1, PTGS2
28gf 109203x44 5912.0PTGS2, PTGER2, CTNNB1, PLA2G2A
29arachidonic acid44 28 11 2414.0SMPD1, PTGS2, PTGER2, PLA2G2A, CTNNB1
30oxygen44 2412.0OGG1, SMPD1, WNT2, FMO3
31o6-methylguanine4411.0APC, MSH6, MSH2
32af/ap4411.0MUTYH, APC
331-hydroxyanthraquinone4411.0CTNNB1, APC
34methylazoxymethanol acetate4410.9CTNNB1, APC
35pidotimod4410.9CTNNB1, AXIN2
36lysophosphatidylcholine44 2811.9APC, ENPP7, PLA2G2A
37curcumin4410.9PTGS2, APC, CTNNB1, ODC1
38glutamate4410.9WNT1
39ndga4410.9PTGS2, PLA2G2A, ODC1
40prostacyclin4410.9PTGS2, APC, PLA2G2A, PTGER2
41pgd24410.9PTGS2, PTGER2, PLA2G2A
428-hydroxyguanine4410.8MUTYH, OGG1
43ah 68094410.7PTGER2, PTGS2
44cisplatin44 49 59 1113.7CTNNB1, PTGS2, MSH2, MSH6, SMPD1
45prostaglandin4410.7ODC1, PTGER2
46diclofenac44 28 49 1113.7PTGS2, PLA2G2A, CTNNB1
47ah2384844 2811.7PTGER2, PTGS2
48nitric oxide44 11 2412.7KLF4, ODC1, PTGER2, OGG1, SMPD1, PTGS2
49tyrosine4410.6WNT1, SMPD1, PTGER2, ODC1, APC, WNT2
50guanine44 11 2412.5MUTYH

GO Terms for genes affiliated with Familial Adenomatous Polyposis

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16Gene Ontology
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Cellular components related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.6AXIN2, CTNNB1, APC
2catenin complexGO:01634210.6CTNNB1, APC2
3MutSalpha complexGO:03230110.5MSH2, MSH6
4cytoplasmic microtubuleGO:00588110.3APC, APC2, AXIN2

Biological processes related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1DNA repairGO:00628111.2OGG1, CSNK1E, MUTYH, NUDT1, MSH6, MSH2
2negative regulation of cell proliferationGO:00828511.1KLF4, APC, CTNNB1, AXIN2, PTGS2, ENPP7
3canonical Wnt receptor signaling pathwayGO:06007011.0WNT1, WNT2, CTNNB1, APC
4small molecule metabolic processGO:04428111.0ODC1, FMO3, NUDT1, PLA2G2A, PTGS2, ENPP7
5maintenance of DNA repeat elementsGO:04357011.0MSH2, MSH6, AXIN2
6mismatch repairGO:00629811.0MUTYH, MSH6, MSH2
7Wnt receptor signaling pathwayGO:01605511.0APC2, CTNNB1, WNT2, WNT1
8T cell differentiation in thymusGO:03307711.0WNT1, CTNNB1, APC
9canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic processGO:04433610.9WNT1, CTNNB1
10regulation of centromeric sister chromatid cohesionGO:07060210.9CTNNB1, AXIN2
11depurinationGO:04500710.9OGG1, MUTYH
12lung inductionGO:06049210.9CTNNB1, WNT2
13response to estradiol stimulusGO:03235510.9PTGS2, CTNNB1, OGG1
14meiotic mismatch repairGO:00071010.9MSH2, MSH6
15sphingomyelin metabolic processGO:00668410.9SMPD1, ENPP7
16positive regulation of helicase activityGO:05109610.9MSH6, MSH2
17somatic recombination of immunoglobulin gene segmentsGO:01644710.9MSH6, MSH2
18negative regulation of DNA recombinationGO:04591010.8MSH2, MSH6
19base-excision repair, AP site formationGO:00628510.8OGG1, MUTYH
20embryonic axis specificationGO:00057810.8CTNNB1, WNT1
21positive regulation of apoptotic processGO:04306510.8APC, CTNNB1, PTGS2, SMPD1
22negative regulation of catenin import into nucleusGO:03541410.8AXIN2, APC2
23negative regulation of canonical Wnt receptor signaling pathwayGO:09009010.8AXIN2, APC2, APC
24dorsal/ventral axis specificationGO:00995010.7CTNNB1, AXIN2
25response to drugGO:04249310.7OGG1, CTNNB1, PTGS2, SMPD1
26somatic hypermutation of immunoglobulin genesGO:01644610.6MSH2, MSH6
27isotype switchingGO:04519010.6MSH2, MSH6
28response to oxidative stressGO:00697910.5PTGS2, NUDT1, OGG1
29determination of adult lifespanGO:00834010.3MSH2, MSH6

Molecular functions related to Familial Adenomatous Polyposis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.0OGG1, CSNK1E, APC, APC2, CTNNB1, MUTYH
2double-stranded DNA bindingGO:00369011.0MSH2, MSH6, CTNNB1, KLF4
3MutLalpha complex bindingGO:03240510.9MSH2, MSH6, MUTYH
4single thymine insertion bindingGO:03214310.9MSH6, MSH2
5single guanine insertion bindingGO:03214210.8MSH2, MSH6
6oxidized purine DNA bindingGO:03235710.8MSH2, MSH6
7beta-catenin bindingGO:00801310.8AXIN2, APC2, APC
8guanine/thymine mispair bindingGO:03213710.8MSH6, MSH2
9four-way junction DNA bindingGO:00040010.8MSH6, MSH2
10enzyme bindingGO:01989910.8CTNNB1, AXIN2, MSH2, PTGS2
11sphingomyelin phosphodiesterase activityGO:00476710.7ENPP7, SMPD1
12hydrolase activity, acting on glycosyl bondsGO:01679810.7SMPD1, MUTYH
13I-SMAD bindingGO:07041110.6AXIN2, CTNNB1
14mismatched DNA bindingGO:03098310.6MSH2, MSH6
15protein kinase bindingGO:01990110.6APC, CTNNB1, AXIN2, MSH2
16receptor agonist activityGO:04801810.3WNT1, WNT2

Products for genes affiliated with Familial Adenomatous Polyposis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Familial Adenomatous Polyposis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet