Familial Adenomatous Polyposis malady

Genetics Home Reference: Familial adenomatous polyposis (FAP) is an inherited disorder characterized by cancer of the large intestine (colon) and rectum. People with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) growths (polyps) in the colon as early as their teenage years. Unless the colon is removed, these polyps will become malignant (cancerous). The average age at which an individual develops colon cancer in classic familial adenomatous polyposis is 39 years. Some people have a variant of the disorder, called attenuated familial adenomatous polyposis, in which polyp growth is delayed. The average age of colorectal cancer onset for attenuated familial adenomatous polyposis is 55 years.¹⁷

MalaCards: Familial Adenomatous Polyposis, also known as adenomatous polyposis coli, is related to attenuated familial adenomatous polyposis and adenomatous polyposis coli. An important gene associated with Familial Adenomatous Polyposis is APC (adenomatous polyposis coli), and among its related pathways are Basal cell carcinoma and WNT Signaling. The drug celecoxib and the compounds threonine and glucose have been mentioned in the context of this disorder. Affiliated tissues include brain, small intestine and colon, and related mouse phenotypes are respiratory system and craniofacial.

Disease Ontology: An autosomal dominant disease that is caused by mutations in the apc gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.⁶

NIH Rare Diseases: Familial adenomatous polyposis (FAP) is an inherited colorectal cancer syndrome. Cancer usually develops in the lower part of the digestive system, including the large intestine (colon) and rectum. People with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) polyps (growths) in the colon as early as their teenage years. The average age at which an individual develops colon cancer in classic familial adenomatous polyposis is about 39 years. Mutations in the APC gene cause classic familial adenomatous polyposis.³⁰

Wikipedia: Familial adenomatous polyposis (FAP) is an inherited condition in which numerous polyps form mainly in...⁴⁴ more...

Aliases & Descriptions:

familial adenomatous polyposis 6 44 30 16 17 8 32 adenomatous polyposis coli 44 30 16 17 43 adenomatous polyposis of the colon 6 44 30 17 fap 44 30 16 17 hereditary polyposis coli 44 30 17 myh-associated polyposis 17 43 colon cancer, familial 44 17 polyposis coli 44 17

familial adenomatous polyposis of the colon 30 polyposis, adenomatous intestinal 30 familial polyposis of the colon 30 familial intestinal polyposis 30 familial multiple polyposis 30 familial polyposis coli 16 colon carcinoma 43 fpc 30

Diseases related to familial adenomatous polyposis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 786)

id	Related Disease	Score	Top Affiliating Genes
1	attenuated familial adenomatous polyposis	38.2	MUTYH, MSH2, MSH6, APC, APEX1, PTGS2
2	adenomatous polyposis coli	36.5	KLF4, REEP5, BTRC, MYC, BMP6, BIRC5
3	mutyh-associated polyposis	36.1	MUTYH, APC, TP53, SMAD4, KRAS
4	desmoid tumor	35.2	PCNA, RB1, SERPINE1, CDH2, MMP7, APC
5	colorectal cancer	35.0	NAT1, NAT2, UGT1A1, MSH2, MLH1, GSTM1
6	gardner syndrome	33.9	KIF3A, APC, MAPRE1, CTNNB1
7	lynch syndrome	33.5	MSH2, MSH6, MLH1, PMS2
8	turcot syndrome	33.3	MSH2, MSH6, MLH1, APC, PMS2
9	juvenile polyposis syndrome	32.7	BMPR1A, APC, PTEN, PTGS2, CTNNB1, SMAD4
10	squamous cell carcinoma	32.5	CDH1, MMP7, GSTP1, CCND1, DAPK1, ODC1
11	familial colorectal cancer	32.0	BRAF, MUTYH, MSH2, MSH6, CDH1, MLH1
12	muir-torre syndrome	31.9	REEP5, MUTYH, MSH2, MSH6, MLH1, PMS1
13	basal cell carcinoma	31.8	BAX, JUP, GSTM1, GSTT1, TP53, PTCH1
14	duodenitis	31.4	PCNA, BRAF, RARB, CLIP1, UGT1A1, UGT1A10
15	ulcerative colitis	31.3	NAT2, MUC2, MSH2, JUP, CD79A, MMP14
16	papillary thyroid carcinoma	31.2	BRAF, RARB, RASSF1, BAX, CDH1, MMP7
17	breast cancer	31.2	BRCA1, MYC, BMP6, CDK4, CDH1, APC
18	thyroid cancer	31.0	BRAF, APC, HSPG2, CTNNA1, PPARG, TG
19	adrenocortical tumor	30.9	BRAF, VHL, MYC, AXIN2, CDK4, APC
20	angiofibroma	30.8	PCNA, VIM, MYC, BMP6, JUP, CDH2
21	inflammatory breast cancer	30.6	MYC, RARB, RASSF1, BIRC5, MUC1, CDH1
22	gastroduodenitis	30.4	BMP6, MUC1, MUC2, MUC5AC, MUC6, XDH
23	polyneuropathy	30.3	BMP6, CLU, CD79A, CD40LG, FKBP1A, GSTM1
24	multiple endocrine neoplasia	30.2	BRCA1, VHL, CDKN1A, CDH2, CDK4, CDH1
25	hepatoblastoma	30.1	PCNA, BTRC, RB1, SERPINE1, VIM, MYC
26	fibromatosis	30.0	PCNA, RB1, SERPINE1, VIM, MYC, CDH2
27	oral submucous fibrosis	30.0	PCNA, BIRC5, GSTM1, GSTT1, HLA-A, TP53
28	arthropathy	29.9	BMP6, CD79A, IL2, ALPPL2, HSPG2, PTGS2
29	hepatitis c	29.6	CD40LG, IRF1, IL2, MAPK8, HLA-A, CYP1A2
30	keloids	29.5	SERPINE1, BMP6, MAPK8, SMAD2, SMAD3
31	carcinoid tumors	29.3	PCNA, RASSF1, MUC1, MSH2, CDKN1A, CDX2
32	nephroblastoma	29.3	VIM, JUP, CAT, TP53, PTEN, CTNNB1
33	was-related disorders	29.2	KIF3A, BRAF, XDH, FBN2, MAPRE1, GNRH1
34	inflammatory bowel disease	29.2	NAT2, MUC2, MUC5AC, XDH, JUP, CDH2
35	colonic neoplasm	29.0	CLU, CDKN1A, CDH1, CA1, TP53, SRC
36	choriocarcinoma	28.8	KLF6, PCNA, MYC, LIFR, JUP, CDKN1A
37	polyposis	28.4	PIN1, KLF4, KLF6, REEP5, KIF3A, PCNA
38	germ cell tumor	28.4	PCNA, RB1, BRAF, VHL, RARB, RASSF1
39	intraepithelial neoplasm	28.1	PCNA, BMP6, MUC1, MUC2, MUC5AC, MUC6
40	colonic polyps	27.5	PCNA, MUC1, MUC2, MSH2, MSH6, JUP
41	adenoma	27.4	KLF4, PCNA, RB1, VIM, NAT1, NAT2
42	ovarian cancer	27.1	RB1, BRCA1, CDKN1A, CDK4, CCND1, TFDP1
43	t-cell leukemia	27.1	MYC, BIRC5, XPO1, CDK4, IL2, MAPK8
44	teratocarcinoma	27.0	SERPINE1, MYC, RARB, RAC1, CDKN1A, INHBA
45	aphthous stomatitis	27.0	IL2, CAT, HLA-A, EGF, TKT, SOD1
46	human t-cell leukemia virus type 1	26.9	PIN1, RB1, MYC, BIRC5, XPO1, CDKN1A
47	oral squamous cell carcinoma	26.8	PIN1, PCNA, RB1, SERPINE1, VIM, BRAF
48	amyloidosis	26.6	CLU, CD79A, CD40LG, CCND1, HSPG2, HLA-A
49	cervical adenocarcinoma	26.5	PCNA, BRAF, MYC, RASSF1, MUC5AC, CDKN1A
50	stomatitis	26.4	BAX, CD79A, IL2, CAT, HLA-A, EGF

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 celecoxib

MalaCards organs/tissues related to familial adenomatous polyposis:

²²

MGI Mouse Phenotypes related to familial adenomatous polyposis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	KIF3A, BRCA1, BMPR1A, FKBP1A, DLG1, SMPD1
2	craniofacial phenotype	MP:0005382	10.3	KLF4, KIF3A, BMPR1A, LEF1, AXIN2, INHBA
3	reproductive system phenotype	MP:0005389	9.8	KLF4, KLF6, BTRC, NAT1, BRCA1, VHL
4	normal phenotype	MP:0002873	9.7	KLF4, REEP5, NAT1, BRAF, BRCA1, VHL
5	hematopoietic system phenotype	MP:0005397	9.6	KLF6, PCNA, BTRC, BRAF, BRCA1, VHL
6	endocrine/exocrine gland phenotype	MP:0005379	9.5	KLF4, BRCA1, BMPR1A, XDH, AXIN2, CDC42
7	pigmentation phenotype	MP:0001186	9.5	RB1, BRAF, BRCA1, MYC, BMPR1A, RAC1
8	other phenotype	MP:0005395	9.1	RARB, CLU, AXIN1, CD40LG, MMP14, IL2
9	embryogenesis phenotype	MP:0005380	9.0	KLF6, KIF3A, VIM, NAT1, BRAF, BRCA1
10	renal/urinary system phenotype	MP:0005367	8.5	KIF3A, BRAF, BRCA1, VHL, RARB, CLU
11	hearing/vestibular/ear phenotype	MP:0005377	8.4	RB1, MYC, BMPR1A, RARB, BAX, AXIN1
12	no phenotypic analysis	MP:0003012	8.3	PCNA, RB1, MYC, MUC1, CD79A, CDH1
13	limbs/digits/tail phenotype	MP:0005371	8.3	KIF3A, RB1, BRCA1, VHL, BMPR1A, RARB
14	liver/biliary system phenotype	MP:0005370	8.3	KLF6, VHL, FKBP1A, GSK3B, IL2, APEX1
15	immune system phenotype	MP:0005387	7.8	BTRC, VIM, BRAF, BRCA1, BMPR1A, CLU
16	integument phenotype	MP:0010771	7.5	PIN1, KLF4, KLF6, RB1, BRAF, BRCA1
17	skeleton phenotype	MP:0005390	7.3	KIF3A, RB1, BRAF, BRCA1, VHL, MYC
18	nervous system phenotype	MP:0003631	7.2	RB1, BRAF, BRCA1, MYC, BMPR1A, RAC1
19	behavior/neurological phenotype	MP:0005386	7.2	KLF4, KIF3A, RB1, VIM, BRAF, BMPR1A
20	mortality/aging	MP:0010768	7.1	KLF4, KLF6, KIF3A, BTRC, RB1, SERPINE1
21	digestive/alimentary phenotype	MP:0005381	7.1	KLF4, KIF3A, RB1, BRAF, BRCA1, VHL
22	muscle phenotype	MP:0005369	7.1	RB1, VIM, BRAF, BRCA1, VHL, MYC
23	adipose tissue phenotype	MP:0005375	6.6	RB1, SERPINE1, BRAF, BRCA1, MYC, LEF1
24	tumorigenesis	MP:0002006	6.5	KLF4, BTRC, RB1, SERPINE1, BRAF, BRCA1
25	vision/eye phenotype	MP:0005391	6.3	PIN1, KIF3A, RB1, VIM, NAT1, BRAF
26	cardiovascular system phenotype	MP:0005385	5.2	KLF6, KIF3A, RB1, SERPINE1, VIM, BRAF
27	cellular phenotype	MP:0005384	5.1	PIN1, KLF4, KLF6, KIF3A, PCNA, BTRC
28	growth/size phenotype	MP:0005378	3.9	PIN1, KLF6, KIF3A, RB1, SERPINE1, BRAF
29	homeostasis/metabolism phenotype	MP:0005376	3.4	KLF4, KIF3A, RB1, SERPINE1, VIM, NAT1

Articles related to familial adenomatous polyposis:

(show top 50)    (show all 271)

id	Title	Authors	Year	Affiliating Genes
1	Family history, surgery, and APC mutation are risk fa ctors for desmoid tumors in familial adenomatous polyposis: an international co hort study. (21904137)	Nieuwenhuis M.H.... Vasen H.F.	2011	APC
2	Functional analysis of MUTYH mutated proteins associa ted with familial adenomatous polyposis. (20418187)	D'Agostino V.G.... Mazzei F.	2010	MUTYH
3	ERI^ expression in normal, adenomatous and carcinomato us tissues of patients with familial adenomatous polyposis. (20446826)	Barone M.... Di Leo A.	2010	ESR2
4	Familial adenomatous polyposis. (19414146)	Macrae F.... Nasioulas S.	2009	APC
5	Wnt pathway, angiogenetic and hormonal markers in sporadic and familial adenomatous polyposis-associated juvenile nasopharyngeal angiofibromas (JNA). (18227724)	Ponti G.... Seidenari S.	2008	CDH1, CTNNB1
6	Culture of primary epithelial adenoma cells from familial adenomatous polyposis patients. (18507027)	Fostira F.... Nasioulas G.	2008	APC
7	Familial adenomatous polyposis in children younger than age ten years: a multidisciplinary clinic experience. (18157572)	Attard T.M.... Lynch H.T.	2008	APC2
8	A large novel deletion in the APC promoter region causes gene silencing and leads to classical familial adenomatous polyposis in a Manitoba Mennonite kindred. (18982352)	Charames G.S.... Bapat B.	2008	APC
9	Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP). (17486639)	Aretz S.... Friedl W.	2007	APC
10	Recurrent idiopathic pancreatitis in familial adenomatous polyposis: report of a case-series and review of the literature. (17318339)	van Esch A.A.... Nagengast F.M.	2007	SPINK1
11	Heterogeneous molecular mechanisms underlie attenuated familial adenomatous polyposis. (18091433)	Cattaneo F.... Ranzani G.N.	2007	APC, OGG1, MSH2
12	A novel exon duplication event leading to a truncatin g germ-line mutation of the APC gene in a familial adenomatous polyposis family . (16736293)	McCart A.... Silver A.	2006	APC
13	APC germ-line mutations in southern Spanish patients with familial adenomatous polyposis: genotype-phenotype correlations and identification of eight novel mutations. (15857185)	GarcA-a-Lozano J.R.... NA_A+ez-RoldA!n A.	2005	APC
14	Nuclear accumulation of beta-catenin without an additional somatic mutation in coding region of the APC gene in hepatoblastoma from a familial adenomatous polyposis patient. (14654913)	Inukai T.... Nakazawa S.	2004	APC, CTNNB1
15	Prostanoids, ornithine decarboxylase, and polyamines in primary chemoprevention of familial adenomatous polyposis. (14762779)	Giardiello F.M.... Yang V.W.	2004	ODC1
16	Familial adenomatous polyposis patients without an identified APC germline mutation have a severe phenotype. (14724162)	Bisgaard M.L.... Bulow S.	2004	APC
17	E-cadherin expression is homogeneously reduced in adenoma from patients with familial adenomatous polyposis: an immunohistochemical study of E-cadherin, beta-catenin and cyclooxygenase-2 expression. (14986031)	Jungck M.... Sauerbruch T.	2004	CDH1, CTNNB1, PTGS2
18	Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli. (15287021)	Blaker H.... Helmke B.M.	2004	APC, CTNNB1
19	Comprehensive genetic and endoscopic evaluation may be necessary to distinguish sporadic versus familial adenomatous polyposis-associated abdominal desmoid tumors. (15179376)	Bandipalliam P.... Syngal S.	2004	APC
20	Familial adenomatous polyposis syndrome (FAP): pathogenesis and molecular mechanisms (14685680)	Friedrich A.... Kullmann F.	2003	GSK3B, CTNNB1, RPS27A
21	Multiple approach to the exploration of genotype-phen otype correlations in familial adenomatous polyposis. (12721244)	Bertario L.... Radice P.	2003	APC
22	A randomized, double-blind, placebo-controlled trial of the effects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on rectal polyps in familial adenomatous polyposis patients. (14581346)	Higuchi T.... Sugihara K.	2003	PTGS2
23	Familial adenomatous polyposis associated with multiple endocrine neoplasia type 1-related tumors and thyroid carcinoma: a case report with clinicopathologic and molecular analyses. (11756777)	Sakai Y.... Kato Y.	2002	APC, CTNNB1
24	Expression of COX-2 and Wnt pathway genes in adenomas of familial adenomatous polyposis patients treated with meloxicam. (12174906)	Dobbie Z.... Bauerfeind P.	2002	MYC, CCND1, PTGS2
25	Pathogenic mutations and rare variants of the APC gene identified in 75 Belgian patients with familial adenomatous polyposis by fluorescent enzymatic mutation detection (EMD). (12173026)	Michils G.... Matthijs G.	2002	APC
26	Molecular diagnosis of familial adenomatous polyposis (FAP): genotyping of adenomatous polyposis coli (APC) alleles by MALDI-TOF mas s spectrometry. (11983341)	Bonk T.... Becker C.M.	2002	APC
27	Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status. (11713587)	Humar B.... Bendik I.	2001	MMP7, ODC1, PRKCB
28	Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli. (11466687)	Su L.K.... Vauthey J.N.	2001	APC
29	Relationship between APC genotype, polyp distribution, and oral sulindac treatment in the colon and rectum of patients with familial adenomatous polyposis. (11535846)	Guldenschuh I.... Scott R.J.	2001	APC
30	Mutation analysis of the adenomatous polyposis coli (APC) gene in northwest Spanish patients with familial adenomatous polyposis (FAP) and sporadic colorectal cancer. (11668620)	Ruiz-Ponte C.... Barros F.	2001	APC
31	Duodenal adenomatosis in familial adenomatous polyposis coli. A review of the literature and results from the Heidelberg Polyposis Register. (11355321)	Kadmon M.... Herfarth C.	2001	APC
32	Congenital hypertrophy of the retinal pigment epithelium and APC mutations in Chinese with familial adenomatous polyposis. (11741105)	Pang C.P.... Lam D.S.	2001	APC
33	Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis. (11751493)	Keller J.J.... Giardiello F.M.	2001	CTNNB1, BAX, PTGS2
34	Germline mutations of the APC gene in patients with familial adenomatous polyposis-associated thyroid carcinoma: results from a European cooperative study. (10634400)	Cetta F.... Olschwang S.	2000	APC
35	Nuclear localization of immunoreactive beta-catenin is specific to familial adenomatous polyposis in papillary thyroid carcinoma. (11092973)	Kurihara K.... Fukayama M.	2000	CTNNB1
36	Marfan-like habitus and familial adenomatous polyposis in two unrelated males: a significant association? (10439970)	Calin G.... Fodde R.	1999	FBN2
37	Adrenocortical tumor in a patient with familial adenomatous polyposis: a case associated with a complete inactivating mutation of the APC gene and unusual histological features. (9496836)	Wakatsuki S.... Horii A.	1998	NR5A1
38	Frequent mutations in the beta-catenin gene in desmoid tumors from patients without familial adenomatous polyposis. (10367940)	Miyoshi Y.... Nakamura Y.	1998	CTNNB1
39	Overexpression of the nonpancreatic secretory group II PLA2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients. (9458096)	Kennedy B.P.... Bapat B.	1998	PLA2G2A
40	Childhood hepatocellular adenoma in familial adenomatous polyposis: mutations in adenomatous polyposis coli gene and p53. (9041254)	Bala S.... Ballhausen W.G.	1997	TP53
41	Novel germline mutations in the APC gene and their phenotypic spectrum in familial adenomatous polyposis kindreds. (9341879)	Walon C.... Verellen-Dumoulin C.	1997	APC
42	Severe upper gastrointestinal polyposis associated with sparse colonic polyposis in a familial adenomatous polyposis family with an APC mutation at codon 1520. (9391252)	Leggett B.A.... Cowen A.E.	1997	APC
43	Clinical and genomic influence of sulindac on rectal mucosa in familial adenomatous polyposis. (9336110)	Winde G.... Osswald H.	1997	HRAS, TP53
44	p53 Protein overexpression in colorectal tumors from patients with familial adenomatous polyposis: is it an early or late event? (8561108)	Levi E.... Rao M.S.	1996	TP53
45	Germline APC mutation (Gln1317) in a cancer-prone family that does not result in familial adenomatous polyposis. (8834176)	White S.... Wyllie A.H.	1996	APC
46	APC mutation in the alternatively spliced region of exon 9 associated with late onset familial adenomatous polyposis. (8522331)	van der Luijt R.B.... Meera Khan P.	1995	APC
47	Exclusion of the APC gene as the cause of a variant form of familial adenomatous polyposis (FAP) (8213830)	Stella A.... Guanti G.	1993	APC
48	Advanced gastroduodenal polyposis with ras mutations in a patient with familial adenomatous polyposis. (8387955)	Odze R.D.... Gallinger S.	1993	GGT3P
49	Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients. (1319835)	Kikuchi-Yanoshita R.... Mori T.	1992	TP53
50	Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay. (1970154)	Yuasa Y.... Tonomura A.	1990	HRAS, NRAS

Genes related to familial adenomatous polyposis according to GeneCards:

(show top 50)    (show all 175)

id	Symbol	Description	Score	GeneCards Section Context
1	APC	adenomatous polyposis coli	11.1	Orthologs, Summaries, Publications
2	MUTYH	mutY homolog (E. coli)	11.0	Publications
3	NUDT1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	11.0	Publications
4	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications, Functions
5	MSH6	mutS homolog 6 (E. coli)	11.0	Publications
6	OGG1	8-oxoguanine DNA glycosylase	11.0	Publications
7	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
8	MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	11.0	Publications
9	APC2	adenomatosis polyposis coli 2	11.0	Orthologs, Publications
10	ENPP7	ectonucleotide pyrophosphatase/phosphodiesterase 7	11.0	Publications
11	KLF4	Kruppel-like factor 4 (gut)	11.0	Publications
12	GUK1	guanylate kinase 1	11.0
13	FMO3	flavin containing monooxygenase 3	11.0	Publications
14	MAPRE1	microtubule-associated protein, RP/EB family, member 1	11.0	Publications
15	MUC6	mucin 6, oligomeric mucus/gel-forming	11.0
16	CSNK1A1	casein kinase 1, alpha 1	11.0
17	CSNK1D	casein kinase 1, delta	11.0
18	CSNK1E	casein kinase 1, epsilon	11.0
19	SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	11.0	Publications
20	GLUL	glutamate-ammonia ligase	11.0	Publications
21	APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	11.0	Publications
22	DKK1	dickkopf 1 homolog (Xenopus laevis)	11.0
23	DVL1	dishevelled, dsh homolog 1 (Drosophila)	11.0
24	PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	11.0	Publications
25	WNT2	wingless-type MMTV integration site family member 2	11.0
26	AXIN1	axin 1	11.0	Publications
27	AXIN2	axin 2	11.0
28	WNT1	wingless-type MMTV integration site family, member 1	11.0
29	ODC1	ornithine decarboxylase 1	11.0	Publications
30	CA1	carbonic anhydrase I	11.0
31	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Publications
32	TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	11.0	Publications
33	MAPRE2	microtubule-associated protein, RP/EB family, member 2	11.0
34	STK11	serine/threonine kinase 11	11.0
35	MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	11.0
36	JUP	junction plakoglobin	11.0
37	IRF1	interferon regulatory factor 1	11.0
38	ILK	integrin-linked kinase	11.0
39	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
40	XPO1	exportin 1 (CRM1 homolog, yeast)	11.0
41	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0
42	LEF1	lymphoid enhancer-binding factor 1	11.0
43	CTNND1	catenin (cadherin-associated protein), delta 1	11.0
44	WNT5A	wingless-type MMTV integration site family, member 5A	11.0
45	PTCH1	patched 1	11.0
46	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	11.0
47	SMAD4	SMAD family member 4	11.0	Publications
48	DLG4	discs, large homolog 4 (Drosophila)	11.0
49	TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	11.0	Publications
50	MUC5AC	mucin 5AC, oligomeric mucus/gel-forming	11.0

Pathways related to familial adenomatous polyposis according to GeneDecks:

(show top 50)    (show all 256)

id	Pathway	Score	Top Affiliating Genes
1	Basal cell carcinoma20	11.2	WNT5A, WNT2, TCF7L2, DVL1, CTNNB1, PTCH1
2	WNT Signaling36	11.2	TCF4, TCF7L2, DKK1, CSNK1A1, CSNK1D, CSNK1E
3	Wnt / Hedgehog / Notch3	11.2	CDX2, PTCH1, WNT5A, CSNK1A1, DKK1, TCF7L2
4	Wnt signaling pathway20	11.1	BTRC, MYC, RAC1, LEF1, DVL1, TCF7L2
5	Colorectal cancer20	11.1	TCF7L2, TGFBR2, SMAD3, SMAD2, MAPK8, APC2
6	Wnt Signaling Pathway37	11.0	WNT1, CSNK1E, CSNK1D, CSNK1A1, PRKCB, TCF7L2
7	Signal transduction_PTEN pathway41	10.7	PCNA, GSK3B
8	Busulfan Pathway, Pharmacodynamics34	10.7	MYC, NAT1, MSH2, NAT2, APEX1, GSTP1
9	Thyroid cancer20	10.7	TCF7L2, KRAS, NRAS, PPARG, CTNNB1, TP53
10	Germ Cell-Sertoli Cell Junction Dynamics36	10.6	CTNNA1, SRC, HRAS, AXIN1, ILK, CDC42
11	G12-G13 in Cellular Signaling36	10.6	RAC1, AXIN1, CDH2, CDC42, CDH13, WNT2
12	TGF-beta Signaling Pathways37	10.4	ESR2, HNF4A, MAPK8, CDC42, TGFBR2, RAC1
13	Cell cycle Regulation of G1/S transition (part 1)10	10.3	CCND1, SMAD4, BTRC, BRCA1, TGFBR2, CDKN1A
14	Cell cycle_Regulation of G1/S transition (part 1)41	10.3	GSK3B, CCND1, PPP2R4, CDKN1A, SMAD3, SMAD4
15	Adherens junction20	10.3	CTNNA1, IQGAP1, CDH1, CDC42, LEF1, RAC1
16	Sertoli-Sertoli Cell Junction Dynamics36	10.2	GSK3B, RAC1, JUP, CDC42, NRAS, CTNND1
17	Factors Promoting Cardiogenesis in Vertebrates36	10.1	HNF4A, TCF7L2, TCF4, TGFBR2, DVL1, CTNNB1
18	Cell Cycle / Checkpoint Control3	10.1	MLH1, MGMT, GSTP1, APEX1, MAPRE1, TP53
19	Drug metabolism - other enzymes20	10.0	UGT2B7, UGT2B4, UGT1A6, UGT1A4, UGT1A10, UGT1A1
20	Chronic myeloid leukemia20	10.0	TP53, CTBP1, SMAD3, SMAD4, TGFBR2, HRAS
21	Drug metabolism - cytochrome P45020	10.0	UGT1A1, UGT1A4, UGT1A10, UGT1A3, CYP1A2, UGT1A6
22	Metabolism of xenobiotics by cytochrome P45020	9.9	UGT1A1, UGT1A10, UGT1A4, UGT1A6, UGT2B4, EPHX1
23	Akt Signaling36	9.6	LIFR, NRAS, TIMP3, PPP2R4, TNFRSF10A, CCND1
24	Translation Non-genomic (rapid) action of Androgen Receptor10	9.3	PTEN, WNT2, WNT5A, DVL1, EGFR, CTNNB1
25	Colorectal Cancer Metastasis36	9.3	BRAF, MYC, BIRC5, PTGS2, SRC, CTNNB1
26	Signal transduction PTEN pathway10	9.3	SRC, PTEN, HRAS, GSK3B, CDKN1A, LEF1
27	Transcription_Androgen Receptor nuclear signaling41	9.2	GSK3B, TGFBR2, WNT5A, WNT1, EGFR, DVL1
28	Transcription Androgen Receptor nuclear signaling10	9.2	CDKN1A, HRAS, CTNNB1, SMAD3, EGF, EGFR
29	Endometrial cancer20	9.1	PTEN, CTNNA1, CTNNB1, NRAS, KRAS, EGF
30	GnRH signaling pathway20	9.1	KRAS, PLA2G2A, PLA2G4A, PLA2G10, NRAS, SRC
31	Non-small cell lung cancer20	9.0	RB1, BRAF, RASSF1, CDK4, HRAS, NRAS
32	JNK Pathway36	8.9	TCF4, RAC1, LIFR, BAX, CDC42, IL2
33	Glioblastoma Multiforme36	8.9	HRAS, TP53, PTEN, SRC, NRAS, EGFR
34	MAPK signaling pathway20	8.7	HRAS, MAP3K1, MAPK8, CDC42, RAC1, MYC
35	Bladder cancer20	8.6	MYC, BRAF, RB1, EGFR, EGF, KRAS
36	EGF Pathway36	8.5	MYC, SRC, EGFR, EGF, NRAS, RAC1
37	ILK Signaling36	8.4	CDC42, CDH2, CTNNB1, PPP2R4, EGF, EGFR
38	Translation_Non-genomic (rapid) action of Androgen Receptor41	8.3	EGFR, EGF, GSK3B, WNT5A, WNT2, CTNNB1
39	Melanoma20	8.3	TP53, CDK4, EGFR, EGF, HRAS, CCND1
40	GSK3 Signaling36	8.2	BTRC, BMP6, LIFR, LEF1, AXIN1, CDH2
41	Prostate cancer20	8.1	RB1, TCF7L2, TGFA, EGFR, EGF, BRAF
42	Pathways in cancer20	8.0	BAX, AXIN1, AXIN2, MSH2, MSH6, JUP
43	Nanog in Mammalian ESC Pluripotency36	8.0	BRAF, BMP6, WNT2, TGFA, TIMP3, DVL1
44	ErbB signaling pathway20	7.9	CDKN1A, MYC, BRAF, TGFA, NRAS, GSK3B
45	Epithelial Adherens Junctions36	7.6	NRAS, HNF4A, CTNND1, CTNNB1, CTNNA1, SRC
46	Glioma20	7.6	TP53, CCND1, BRAF, CDKN1A, HRAS, PRKCB
47	TGF-Beta Pathway36	7.3	IL2, NRAS, EGF, EGFR, TIMP3, TGFA
48	Pancreatic Adenocarcinoma36	7.2	CDK4, TGFBR2, MMP7, ARHGEF4, IL2, CCND1
49	MAPK Signaling36	7.1	LIFR, EGFR, TIMP3, TGFA, TCF4, TCF7L2
50	Molecular Mechanisms of Cancer36	6.8	EGF, EGFR, TIMP3, DVL1, TGFA, TGFBR2

Compounds related to familial adenomatous polyposis according to GeneDecks:

(show top 50)    (show all 496)

id	Compound	Score	Top Affiliating Genes
1	threonine32	10.8	BMPR1A, MUC2, MUC5AC, AXIN2, MSH6, CDC42
2	glucose32	10.8	BRAF, VHL, XPO1, CDK4, MGMT, APC
3	exisulind32	10.6	BAX, CDH1, APC, MAPK8, CCND1, PTGS2
4	o6-methylguanine32	10.4	PCNA, BRAF, RARB, RASSF1, MSH2, MSH6
5	8-oxo-dg32	10.4	PCNA, MUTYH, APEX1, TP53, OGG1, NUDT1
6	8-oxoguanine32	10.2	PCNA, BRCA1, MUTYH, CDKN1A, MGMT, GSTM1
7	camptothecin32 42 9 9	12.7	PCNA, RB1, BRCA1, MYC, BIRC5, CLU
8	atp32	9.6	RB1, BRAF, BRCA1, RAC1, BIRC5, CLU
9	nocodazole32 42 9 9	12.5	PIN1, VIM, BRCA1, RAC1, BIRC5, CLIP1
10	celecoxib32 42 34 9 18 9	14.4	PCNA, BIRC5, BAX, CDKN1A, CDH1, APC
11	biotin32 9 18 9	12.4	KLF4, PCNA, RB1, VIM, MUC1, MSH2
12	indole-3-carbinol32	9.4	BRCA1, BIRC5, BAX, CDKN1A, CDK4, CDH1
13	adpribose32	9.3	PCNA, RB1, BRCA1, BIRC5, BAX, CDKN1A
14	arsenite32 18	10.3	PCNA, MYC, RAC1, BIRC5, BAX, CDKN1A
15	calcium32 9 18 9	12.1	PIN1, RB1, BRAF, BRCA1, VHL, RAC1
16	wortmannin32 42	10.1	VIM, BRAF, RAC1, BIRC5, BAX, CDKN1A
17	n acetylcysteine32	9.1	PCNA, BIRC5, CLU, MUC5AC, CD79A, CDKN1A
18	4-hydroxytamoxifen32	9.0	BRCA1, MYC, CLU, UGT1A4, CDH2, SRC
19	ascorbic acid32 18	10.0	PCNA, NAT1, RAC1, CD40LG, CDK4, GSTM1
20	losartan32 34 9 9	11.9	PCNA, SERPINE1, BMP6, UGT1A1, UGT1A10, UGT1A3
21	ndga32	8.9	HSPG2, CAT, PTGS2, PTGS1, ODC1, PPARG
22	nitric oxide32 9 18 9	11.7	KLF4, KLF6, RB1, NAT1, NAT2, VHL
23	irinotecan32 34 9 9	11.7	BRAF, UGT1A1, UGT1A6, BAX, CDKN1A, CDH1
24	methotrexate32 34 42 9 9	12.7	PCNA, RB1, SERPINE1, VIM, NAT2, BRCA1
25	aspirin32 34 18	10.6	PCNA, SERPINE1, BMP6, BIRC5, UGT1A6, CD79A
26	tgf beta132	8.6	SERPINE1, VIM, BMP6, CDKN1A, CDK4, CDH1
27	matrigel32	8.4	RB1, SERPINE1, VIM, BRAF, BMP6, RAC1
28	mg 13232 42	9.3	PCNA, BRCA1, MYC, BIRC5, BAX, CDKN1A
29	cholesterol32 9 18 9	11.3	RB1, SERPINE1, NAT2, RAC1, LIFR, BIRC5
30	dihydrotestosterone32 9 18 9	11.2	SERPINE1, VIM, BMP6, CLU, UGT1A4, UGT2B15
31	butyrate32	8.2	KLF4, PCNA, RB1, VIM, MYC, BMP6
32	retinoid32	8.0	VIM, MYC, BMP6, RARB, MUC5AC, BAX
33	lactate32	8.0	PCNA, VIM, BMP6, BIRC5, CLU, XDH
34	thymidylate32	7.9	PCNA, RB1, VIM, BRCA1, BIRC5, UGT1A1
35	gf 109203x32 42	8.9	CDKN1A, MAPK8, CCND1, GNRH1, HSPG2, HRAS
36	agar32	7.7	RB1, VIM, BRAF, BRCA1, RARB, RASSF1
37	herbimycin a32 42	8.6	MYC, BMP6, CD40LG, CDK4, CDH1, MMP14
38	estradiol32 9 18 9	10.5	PCNA, RB1, SERPINE1, VIM, BRCA1, RARB
39	calcitriol32 42 9 18 9	11.5	RB1, MYC, BMP6, RARB, CLU, XPO1
40	lipid32	7.4	RB1, SERPINE1, VIM, BRAF, BRCA1, RARB
41	pd 98,05932	7.0	KLF4, RB1, SERPINE1, BRAF, MYC, BMP6
42	indomethacin32 9 9	9.0	PCNA, VIM, MYC, BMP6, BIRC5, UGT1A1
43	estrogen32	7.0	KLF6, PCNA, SERPINE1, NAT1, NAT2, BRCA1
44	actinomycin d32	6.9	RB1, SERPINE1, VIM, VHL, MYC, RARB
45	thymidine32 18	7.8	KLF4, PCNA, RB1, BRCA1, MYC, BMP6
46	paraffin32	6.7	PCNA, RB1, VIM, BRAF, BRCA1, MYC
47	retinoic acid32 42 18	8.6	RB1, SERPINE1, BRAF, BRCA1, MYC, BMP6
48	creatinine32	6.5	PCNA, SERPINE1, VIM, BMP6, MUC1, CD79A
49	tamoxifen32 34 9 9	8.4	PCNA, VIM, BRCA1, MYC, BMP6, BIRC5
50	genistein32 9 18 9	8.0	PCNA, RB1, SERPINE1, VIM, BRCA1, MYC

Cellular components related to familial adenomatous polyposis according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	lateral plasma membrane	GO:016328	11.0	DVL1, CTNNB1, DLG1, APC, IQGAP1, CDH1
2	catenin complex	GO:016342	10.9	CTNNB1, CTNNA1, APC2, CDH1, CDH2, JUP
3	Axin-APC-beta-catenin-GSK3B complex	GO:034747	10.9	CTNNB1, APC, GSK3B, AXIN2, AXIN1
4	cell-cell adherens junction	GO:005913	10.8	DSC2, CTNND1, CTNNB1, APC, CDH1, CDH2
5	APC-Axin-1-beta-catenin complex	GO:034742	10.7	AXIN1, APC, CTNNB1
6	protein-DNA complex	GO:032993	10.7	TCF7L2, CTNNB1, JUP, LEF1
7	transcription factor complex	GO:005667	10.7	TCF4, TFDP1, SMAD4, SMAD3, SMAD2, CTNNB1
8	cytoplasmic microtubule	GO:005881	10.7	MAPRE1, APC2, APC, CLIP1, BIRC5
9	cell-cell junction	GO:005911	10.6	JUP, CDH2, ILK, DLG1, CTNNA1, CTNNB1
10	SMAD protein complex	GO:071141	10.4	SMAD2, SMAD3, SMAD4
11	caveola	GO:005901	10.2	TGFBR2, SRC, PTGS2, PTCH1, CDH13, BMPR1A
12	internal side of plasma membrane	GO:009898	10.0	ACP1, DLG1, PTEN, CDH1, JUP
13	nucleoplasm	GO:005654	9.4	NR5A1, PPARD, PPARA, PPARG, DDIT3, TP53
14	cytoplasm	GO:005737	8.8	DAPK1, SRP19, CTBP1, CTNNB1, CTNND1, PPP2R4
15	endoplasmic reticulum membrane	GO:005789	8.8	PTGS1, DLG1, CYP1A2, PPM1L, PLA2G4A, PLA2G2A
16	cytosol	GO:005829	8.1	CSNK1E, CTNNA1, ODC1, SRP19, SRC, DLG1
17	nucleus	GO:005634	7.1	PPP2R4, PPARA, PPARD, NR5A1, SMAD2, SMAD3
18	extracellular space	GO:005615	6.5	PLA2G2A, EGF, EGFR, ACE, TGFA, DKK1
19	plasma membrane	GO:005886	6.0	SMAD3, NRAS, CTNND1, CTNNB1, CTNNA1, SRC

Biological processes related to familial adenomatous polyposis according to GeneDecks:

(show top 50)    (show all 85)

id	Name	GO ID	Score	Top Affiliating Genes
1	Wnt receptor signaling pathway	GO:016055	11.2	CTNNB1, WNT2, CSNK1D, CSNK1A1, MCC, APC2
2	negative regulation of canonical Wnt receptor signaling pathway	GO:090090	11.1	CTNND1, LEF1, WNT5A, DKK1, TCF7L2, DDIT3
3	canonical Wnt receptor signaling pathway	GO:060070	11.0	DVL1, TCF7L2, STK11, WNT1, WNT2, WNT5A
4	cellular response to indole-3-methanol	GO:071681	10.9	BRCA1, JUP, CDH1, CTNNA1, CTNNB1
5	cell-cell junction organization	GO:045216	10.9	RAC1, JUP, CDH2, HNF4A, CTNNA1, CTNND1
6	adherens junction organization	GO:034332	10.9	CDH13, CTNND1, CTNNA1, CDH1, CDH2, JUP
7	maintenance of DNA repeat elements	GO:043570	10.9	MSH2, MSH6, TCF7L2, AXIN2
8	positive regulation of canonical Wnt receptor signaling pathway	GO:090263	10.8	ILK, JUP, SRC, DVL1, SMAD3, CSNK1D
9	DNA repair	GO:006281	10.8	APEX1, PCNA, RPS27A, OGG1, NUDT1, MUTYH
10	positive regulation of protein phosphorylation	GO:001934	10.7	AXIN1, PIN1, CSNK1D, AXIN2, CCND1, HRAS
11	mismatch repair	GO:006298	10.7	PMS2, MSH6, MSH2, MUTYH, PCNA
12	negative regulation of transforming growth factor beta receptor signaling pathway	GO:030512	10.7	XPO1, SMAD2, TP53, SMAD3, RPS27A, WNT1
13	negative regulation of transcription, DNA-dependent	GO:045892	10.6	TCF7L2, TP53, CTBP1, CTNNB1, PPARG, PPARD
14	response to organic cyclic compound	GO:014070	10.6	CTNNA1, LEF1, WNT5A, TIMP3, PTGS2, CCND1
15	protein phosphorylation	GO:006468	10.6	PRKCB, CSNK1A1, CSNK1D, CSNK1E, ILK, TGFBR2
16	response to DNA damage stimulus	GO:006974	10.6	POLB, STK11, DDIT3, MYC, BAX, TP53
17	base-excision repair	GO:006284	10.5	POLB, OGG1, TP53, APEX1, MUTYH, PCNA
18	negative regulation of transcription from RNA polymerase II promoter	GO:000122	10.5	DKK1, PPARG, PPARA, PPARD, SMAD2, PTCH1
19	negative regulation of cell proliferation	GO:008285	10.5	AXIN2, APC, INHBA, IRF1, CDH13, KLF4
20	cell cycle arrest	GO:007050	10.5	IRF1, INHBA, ILK, APC, HRAS, STK11
21	cellular glucuronidation	GO:052695	10.4	UGT2B7, UGT2B4, UGT2B15, UGT1A10
22	induction of apoptosis by intracellular signals	GO:008629	10.4	HRAS, BAX, CDKN1A, MSH6, CLU, MYC
23	organ regeneration	GO:031100	10.4	PPARG, CDKN1A, LIFR, LEF1, UGT1A1, WNT1
24	xenobiotic metabolic process	GO:006805	10.4	CYP1A2, HNF4A, GSTP1, GSTM1, GSTA1, FMO3
25	positive regulation of apoptotic process	GO:043065	10.4	SOD1, PLA2G4A, DDIT3, PPP2R4, SMPD1, PTGS2
26	striated muscle cell differentiation	GO:051146	10.3	RB1, CDH2, HRAS, NRAS, KRAS
27	transforming growth factor beta receptor signaling pathway	GO:007179	10.3	TFDP1, TGFBR2, SERPINE1, MYC, BMPR1A, XPO1
28	negative regulation of sequence-specific DNA binding transcription factor activity	GO:043433	10.3	RB1, BTRC, DDIT3, PLA2G10, TCF7L2, HNF4A
29	regulation of cell proliferation	GO:042127	10.3	MMP7, PTGER2, TGFBR2, DNMT1, SERPINE1, PIN1
30	response to drug	GO:042493	10.1	PTGS2, DDIT3, SRP19, CTNNB1, TGFBR2, TGFA
31	palate development	GO:060021	10.1	INHBA, WNT5A, BMPR1A, LEF1, SMAD2, SMAD4
32	wound healing	GO:042060	10.0	WNT5A, KLF6, TGFA, SMAD3, PPARD, PPARA
33	negative regulation of cell growth	GO:030308	10.0	CDKN1A, RB1, ESR2, SMAD4, PPARG, HNF4A
34	transcription initiation from RNA polymerase II promoter	GO:006367	10.0	SMAD4, MYC, RARB, ESR2, HNF4A, SERPINE1
35	mitotic cell cycle	GO:000278	9.9	BIRC5, PCNA, CSNK1E, CDKN1A, XPO1, CLIP1
36	negative regulation of epithelial cell proliferation	GO:050680	9.9	WNT5A, DLG1, PTEN, ESR2, MCC, RB1
37	positive regulation of transcription, DNA-dependent	GO:045893	9.9	RB1, BRCA1, VHL, MYC, BMPR1A, LEF1
38	negative regulation of neuron apoptotic process	GO:043524	9.8	BAX, SOD1, ILK, HRAS, NRAS, KRAS
39	Ras protein signal transduction	GO:007265	9.8	SRC, KRAS, NRAS, TP53, HRAS, CDKN1A
40	positive regulation of fibroblast proliferation	GO:048146	9.8	EGFR, WNT5A, WNT2, CDKN1A, MYC, WNT1
41	apoptotic process	GO:006915	9.6	MAPK8, TP53, PRKCB, DAPK1, CTNNB1, TGFBR2
42	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	GO:2000060	9.6	EGF, CLU, AXIN1, PTEN
43	negative regulation of apoptotic process	GO:043066	9.3	WNT5A, GSK3B, SERPINE1, GSTP1, APC, MAPK8
44	small molecule metabolic process	GO:044281	9.3	XDH, UGT1A6, UGT1A4, UGT1A1, PLA2G4A, NAT2
45	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.1	RPS27A, SMAD4, SMAD3, SMAD2, NR5A1, PPARA
46	cell proliferation	GO:008283	9.1	SMAD4, PCNA, AXIN2, ILK, MAPRE1, MAPRE2
47	anti-apoptosis	GO:006916	8.8	TGFA, MUC1, TCF7L2, SOD1, POLB, VHL
48	blood coagulation	GO:007596	8.7	PRKCB, PLA2G4A, EGF, HRAS, NRAS, SRC
49	positive regulation of cell proliferation	GO:008284	8.4	PTEN, HRAS, ILK, IL2, CDK4, LEF1
50	epidermal growth factor receptor signaling pathway	GO:007173	8.1	TGFA, SRC, RPS27A, NRAS, HRAS, CDC42

Molecular functions related to familial adenomatous polyposis according to GeneDecks:

(show all 28)

id	Name	GO ID	Score	Top Affiliating Genes
1	beta-catenin binding	GO:008013	11.0	TCF7L2, SMAD3, CTNNA1, APC2, APC, GSK3B
2	I-SMAD binding	GO:070411	10.9	SMAD4, SMAD2, CTNNB1, AXIN2, AXIN1
3	cadherin binding	GO:045296	10.9	CTNND1, CTNNB1, CTNNA1, APC, CDH13, JUP
4	gamma-catenin binding	GO:045295	10.9	TCF7L2, CTNNA1, APC, CDH1, CDH2, LEF1
5	R-SMAD binding	GO:070412	10.8	SMAD4, SMAD3, SMAD2, CTNNB1, AXIN1
6	transcription regulatory region DNA binding	GO:044212	10.8	SMAD3, SMAD4, TCF7L2, WNT1, WNT5A, PPARG
7	MutLalpha complex binding	GO:032405	10.7	MSH6, MSH2, MUTYH, PCNA
8	mismatched DNA binding	GO:030983	10.6	PMS1, MLH1, MSH6, MSH2
9	MutSalpha complex binding	GO:032407	10.5	MUTYH, MLH1, PMS2
10	protein C-terminus binding	GO:008022	10.5	DLG4, CTBP1, CTNNB1, TCF4, DLG1, HRAS
11	transcription factor binding	GO:008134	10.5	CTNNB1, SMAD2, SMAD3, TFDP1, DNMT1, TCF7L2
12	SMAD binding	GO:046332	10.5	TGFBR2, SMAD2, CTNNB1, FKBP1A, AXIN1, BMPR1A
13	protein kinase binding	GO:019901	10.5	CCND1, TP53, PTEN, DLG1, SMAD3, ELAVL1
14	protein domain specific binding	GO:019904	10.4	WNT5A, WNT1, TFDP1, PPARA, CTNND1, CTBP1
15	retinoic acid binding	GO:001972	10.4	UGT2B7, UGT2B4, UGT2B15, UGT1A6, UGT1A4, UGT1A3
16	glucuronosyltransferase activity	GO:015020	10.4	UGT2B7, UGT2B4, UGT2B15, UGT1A6, UGT1A4, UGT1A3
17	steroid hormone receptor activity	GO:003707	10.3	NR5A1, PPARD, PPARA, PPARG, ESR2, HNF4A
18	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	10.2	NR5A1, PPARD, PPARA, PPARG, ESR2, HNF4A
19	mitogen-activated protein kinase kinase binding	GO:031434	10.2	DLG1, MAP3K1, BRAF, PIN1
20	ubiquitin protein ligase binding	GO:031625	10.1	SMAD3, SMAD2, TP53, GSK3B, AXIN2, AXIN1
21	sequence-specific DNA binding transcription factor activity	GO:003700	10.1	CTNNB1, PPARG, PPARA, PPARD, SMAD2, SMAD3
22	double-stranded DNA binding	GO:003690	10.0	EGFR, SMAD3, SMAD2, NR5A1, CTNNB1, MSH6
23	protein phosphatase binding	GO:019903	10.0	EGFR, CTNND1, CTNNB1, IQGAP1, CDH1, CDH2
24	protein homodimerization activity	GO:042803	9.5	JUP, CAT, HNF1A, HNF4A, PTGS2, PPP2R4
25	identical protein binding	GO:042802	9.4	DVL1, EGFR, SMAD4, TP53, GLUL, MAP3K1
26	protein heterodimerization activity	GO:046982	9.1	BAX, INHBA, HNF1A, TP53, PPP2R4, EGFR
27	enzyme binding	GO:019899	8.9	AXIN2, MSH2, CCND1, CAT, ESR2, TP53
28	protein binding	GO:005515	5.1	SRC, ACP1, ELAVL1, TIMP3, DVL1, TGFA