MCID: FML108
MIFTS: 35

Familial Breast Cancer malady

Cancer diseases, Genetic diseases categories

Summaries for Familial Breast Cancer

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32MalaCards
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MalaCards: Familial Breast Cancer, also known as breast cancer, familial, is related to breast cancer and bilateral breast cancer. An important gene associated with Familial Breast Cancer is MIR27A (microRNA 27a), and among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR. The compounds hydroxyurea and adriamycin have been mentioned in the context of this disorder. Affiliated tissues include breast.

Aliases & Classifications for Familial Breast Cancer

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Sources:
42NIH Rare Diseases, 20GeneTests, 22GTR, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases


Aliases & Descriptions:

familial breast cancer 42
breast cancer, familial 42 20 22
familial cancer of breast 60
heritable breast cancer 42
genetic breast cancer 42


Related Diseases for Familial Breast Cancer

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17GeneCards, 18GeneDecks
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Diseases in the Breast Cancer family:

Inflammatory Breast Carcinoma Breast Benign Neoplasm
Breast Carcinoma in Situ familial breast cancer
Chek2-Related Susceptibility to Breast Cancer Bard1-Related Susceptibility to Breast Cancer
Brip1-Related Breast Cancer Breast Cancer, Type 3
Breast Cancer, Early-Onset

Diseases related to Familial Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.9BRCA2, BRCA1
2bilateral breast cancer30.5BRCA1, BRCA2, CHEK2
3male breast cancer30.2BRCA2, BRCA1
4ovarian cancer30.0BRCA2, BRCA1, CHEK2
5brca1 and brca2 hereditary breast and ovarian cancer30.0BRCA1, BRCA2
6breast-ovarian cancer, familial, 230.0BRCA2
7bloom syndrome30.0BRCA1, BRCA2
8colorectal cancer30.0BRCA2, CHEK2, BRCA1
9pancreatitis30.0BRCA2
10cowden disease30.0BRCA1, BRCA2
11sporadic breast cancer10.6
12breast disease10.4
13ataxia telangiectasia10.2
14chromosomal disease10.2
15breast/ovarian cancer, hereditary: brca1/brca2 sequence analysis and deletion/duplication analysis panels10.1
16bannayan-riley-ruvalcaba syndrome10.0
17werner syndrome10.0
18hereditary breast ovarian cancer10.0
19nevoid basal cell carcinoma syndrome10.0
20basal cell carcinoma10.0
21breast fibroadenoma10.0
22breast sarcoma10.0
23colon cancer10.0
24pancreatic cancer10.0
25prostate cancer10.0
26prostatitis10.0
27sarcoma10.0
28thyroid cancer10.0
29thyroiditis10.0
30stomach cancer10.0BRCA2, CHEK2, BRCA1
31fallopian tube cancer10.0BRCA1, BRCA2
32atypical mole syndrome10.0ARL11, BRCA2
33lynch syndrome10.0BRCA2, BRCA1
34hepatocellular carcinoma10.0BRCA2
35familial colorectal cancer10.0BRCA2, BRCA1
36retinoblastoma10.0BRCA1, BRCA2, CHEK2
37li-fraumeni syndrome10.0BRCA1, BRCA2
38peritoneal carcinoma10.0BRCA2, BRCA1

Graphical network of the top 20 diseases related to Familial Breast Cancer:



Diseases related to familial breast cancer

Clinical Features for Familial Breast Cancer

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Drugs & Therapeutics for Familial Breast Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Familial Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Familial Breast Cancer

Search NIH Clinical Center for Familial Breast Cancer

Search CenterWatch for Familial Breast Cancer

Genetic Tests for Familial Breast Cancer

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20GeneTests, 22GTR
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Genetic tests related to Familial Breast Cancer:

id Genetic test Affiliating Genes
1 Familial Breast Cancer20
2 Familial Cancer of Breast22

Anatomical Context for Familial Breast Cancer

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32MalaCards
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MalaCards organs/tissues related to Familial Breast Cancer:

32
Breast

Animal Models for Familial Breast Cancer or affiliated genes

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Publications for Familial Breast Cancer

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Genetic Variations for Familial Breast Cancer

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Expression for genes affiliated with Familial Breast Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Breast Cancer

Search GEO for disease gene expression data for Familial Breast Cancer.

Pathways for genes affiliated with Familial Breast Cancer

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Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 53Reactome
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Pathways related to Familial Breast Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8MIR125B1, BRCA1, MIR20A, MIR146A, MIR128-2, MIR125A
210.6MIR20A, MIR17, MIR223, MIR27A, MIR24-1
310.6CHEK2, BRCA2, BRCA1
410.6BRCA1, BRCA2, CHEK2
5
DNA damage Role of Brca1 and Brca2 in DNA repair
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10.6CHEK2, BRCA2, BRCA1
6
Hide members
10.5BRCA2, BRCA1
710.5CHEK2, BRCA1

Compounds for genes affiliated with Familial Breast Cancer

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Familial Breast Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hydroxyurea44 49 1112.7CHEK2, BRCA2, BRCA1
2adriamycin4410.6CHEK2
3bpde4410.6CHEK2, BRCA1
4camptothecin44 59 1112.6BRCA1, BRCA2, CHEK2
5lycopene44 2411.5BRCA2, BRCA1
68-oxoguanine4410.4BRCA2, BRCA1
7daidzein4410.2BRCA2, BRCA1

GO Terms for genes affiliated with Familial Breast Cancer

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16Gene Ontology
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Biological processes related to Familial Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-strand break repairGO:00630210.6CHEK2, BRCA2, BRCA1
2response to gamma radiationGO:01033210.5CHEK2, BRCA2
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.4BRCA2, BRCA1
4intrinsic apoptotic signaling pathway in response to DNA damageGO:00863010.2CHEK2, BRCA1

Products for genes affiliated with Familial Breast Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Familial Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet