MCID: FML108
MIFTS: 45

Familial Breast Cancer malady

Cancer, Genetic categories

Summaries for Familial Breast Cancer

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Familial Breast Cancer, also known as breast cancer, familial, is related to bilateral breast cancer and male breast cancer. An important gene associated with Familial Breast Cancer is MIR27A (microRNA 27a), and among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR. The compounds hydroxyurea and adriamycin have been mentioned in the context of this disorder. Affiliated tissues include whole blood, colon and thyroid.

Aliases & Classifications for Familial Breast Cancer

Sources:
43NIH Rare Diseases, 20GeneTests, 22GTR, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer, Genetic


Aliases & Descriptions:

familial breast cancer 43
breast cancer, familial 43 20 22
familial cancer of breast 61
heritable breast cancer 43
genetic breast cancer 43


Related Diseases for Familial Breast Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the breast cancer family:

bilateral breast cancer familial breast cancer
breast cancer, type 3 breast cancer, early-onset

Diseases related to Familial Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1bilateral breast cancer30.5BRCA1, BRCA2, CHEK2
2male breast cancer30.3BRCA2, BRCA1
3breast-ovarian cancer, familial, 230.0BRCA2
4bloom syndrome30.0BRCA1, BRCA2
5colorectal cancer30.0BRCA2, CHEK2, BRCA1
6cowden disease30.0BRCA1, BRCA2
7breast cancer susceptibility10.6
8sporadic breast cancer10.6
9breast cancer, early-onset10.6
10fanconi's anemia10.2
11ataxia telangiectasia10.2
12ataxia10.2
13breast/ovarian cancer, hereditary: brca1/brca2 sequence analysis and deletion/duplication analysis panels10.1
14bannayan-riley-ruvalcaba syndrome10.0
15werner syndrome10.0
16hereditary breast ovarian cancer10.0
17nevoid basal cell carcinoma syndrome10.0
18n syndrome10.0
19basal cell carcinoma10.0
20thyroid cancer10.0
21nevo syndrome10.0
22familial prostate cancer10.0
23oral cancer10.0
24ruvalcaba syndrome10.0
25soft tissue sarcoma10.0
26breast cancer, somatic10.0
27germ cell cancer10.0
28ovarian cancer10.0BRCA2, BRCA1, CHEK2
29stomach cancer10.0BRCA2, CHEK2, BRCA1
30brca1 and brca2 hereditary breast and ovarian cancer10.0BRCA1, BRCA2
31fallopian tube cancer10.0BRCA1, BRCA2
32atypical mole syndrome10.0ARL11, BRCA2
33breast cancer10.0BRCA2, BRCA1
34lynch syndrome10.0BRCA2, BRCA1
35hepatocellular carcinoma10.0BRCA2
36pancreatitis10.0BRCA2
37familial colorectal cancer10.0BRCA2, BRCA1
38retinoblastoma10.0BRCA1, BRCA2, CHEK2
39li-fraumeni syndrome10.0BRCA1, BRCA2
40peritoneal carcinoma10.0BRCA2, BRCA1

Graphical network of the top 20 diseases related to Familial Breast Cancer:



Diseases related to familial breast cancer

Clinical Features for Familial Breast Cancer

Drugs & Therapeutics for Familial Breast Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Familial Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Familial Breast Cancer

Search NIH Clinical Center for Familial Breast Cancer

Search CenterWatch for Familial Breast Cancer

Genetic Tests for Familial Breast Cancer

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Familial Breast Cancer:

id Genetic test Affiliating Genes
1 Familial Breast Cancer20
2 Familial Cancer Of Breast22

Anatomical Context for Familial Breast Cancer

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Familial Breast Cancer:

33
Whole blood, Colon, Thyroid, Breast, Prostate, T cells, B cells, Fetal thyroid

Animal Models for Familial Breast Cancer or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Familial Breast Cancer

Sources:
51PubMed
See all sources

Articles related to Familial Breast Cancer:

(show top 50)    (show all 482)
idTitleAuthorsYear
1
A Novel Splice Site Mutation in the Non-coding Region of BRCA2: Implications for Fanconi Anemia and Familial Breast Cancer Diagnostics. (24395671)
2014
2
Do BRCA1 and BRCA2 mutation carriers have earlier natural menopause than their noncarrier relatives? Results from the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer. (24081944)
2013
3
Mutation screening of the BRCA1 gene in early onset and familial breast/ovarian cancer in Moroccan population. (23289006)
2013
4
Impact of familial risk and mammography screening on prognostic indicators of breast disease among women from the Ontario site of the Breast Cancer Family Registry. (24097051)
2013
5
Validation, calibration and refitting of a familial breast cancer model in sisterships: a case study in the Swedish sisters data. (23508778)
2013
6
The SNP rs895819 in miR-27a is not associated with familial breast cancer risk in Italians. (22415478)
2012
7
Two novel variants in the 3'UTR of the BRCA1 gene in familial breast and/or ovarian cancer. (20848184)
2011
8
A new mutation of BRCA2 gene in an Italian healthy woman with familial breast cancer history. (20878484)
2011
9
Old and new concepts in histopathological characterization of familial breast cancer. (21285147)
2011
10
An intronic mutation in MLH1 associated with familial colon and breast cancer. (20717847)
2011
11
RAD51C germline mutations in Chinese women with familial breast cancer. (21597919)
2011
12
Glycodelin expression associates with differential tumour phenotype and outcome in sporadic and familial non-BRCA1/2 breast cancer patients. (20676758)
2011
13
An association between invasive breast cancer and familial idiopathic hyperparathyroidism: a case series and review of the literature. (18500673)
2009
14
Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors. (18563556)
2009
15
Polymorphisms in BRCA2 resulting in aberrant codon-usage and their analysis on familial breast cancer risk. (19229607)
2009
16
Contribution of XPD (Lys751Gln) and XRCC1 (Arg399Gln) polymorphisms in familial and sporadic breast cancer predisposition and survival: an Indian report. (19051060)
2009
17
Cyclin D1 expression analysis in familial breast cancers may discriminate BRCAX from BRCA2-linked cases. (18327210)
2008
18
Distinct genomic aberration patterns are found in familial breast cancer associated with different immunohistochemical subtypes. (18071313)
2008
19
Familial breast cancers without mutations in BRCA1 or BRCA2 have low cyclin E and high cyclin D1 in contrast to cancers in BRCA mutation carriers. (18381935)
2008
20
Tissue microarrays for testing basal biomarkers in familial breast cancer cases. (17992394)
2007
21
Study on gene control region of mitochondrial DNA in familial breast cancer]. (17922420)
2007
22
Cost-effectiveness of screening with contrast enhanced magnetic resonance imaging vs X-ray mammography of women at a high familial risk of breast cancer. (17016484)
2006
23
Evaluation of RAD50 in familial breast cancer predisposition. (16385572)
2006
24
What's the message? Interpretation of an uninformative BRCA1/2 test result for women at risk of familial breast cancer. (15834241)
2005
25
BRCA1 and BRCA2 mutations in patients with familial breast cancer]. (15683621)
2005
26
Differences in individual approaches: communication in the familial breast cancer consultation and the effect on patient outcomes. (15789155)
2005
27
Feeling at risk: how women interpret their familial breast cancer risk. (15382029)
2004
28
Costs and benefits of diagnosing familial breast cancer. (15280189)
2004
29
Evaluation of the diagnostic accuracy of the stop codon (SC) assay for identifying protein-truncating mutations in the BRCA1and BRCA2genes in familial breast cancer. (12624724)
2003
30
Contributions of ATM mutations to familial breast and ovarian cancer. (12810666)
2003
31
Familial breast cancer and the hCHK2 1100delC mutation: assessing cancer risk. (12793891)
2003
32
BRCA1 and BRCA2 mutations in Russian familial breast cancer. (11793480)
2002
33
Oral contraceptives and risk of familial breast cancer. (12088199)
2002
34
A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes. (11857015)
2002
35
BRCA2 gene mutations in Greek patients with familial breast cancer. (11754111)
2002
36
Significantly lower rates of BRCA1/BRCA2 founder mutations in Ashkenazi women with sporadic compared with familial early onset breast cancer. (10885601)
2000
37
Management of familial breast cancer risk. (10989983)
2000
38
Familial breast cancer: the problems of circumstantial evidence. (11315714)
2000
39
A comparison of methods currently used in clinical practice to estimate familial breast cancer risks. (10847465)
2000
40
The pathology of familial breast cancer: Clinical and genetic counselling implications of breast cancer pathology. (11250683)
1999
41
The pathology of familial breast cancer: How do the functions of BRCA1 and BRCA2 relate to breast tumour pathology? (11250682)
1999
42
Genes responsible for familial breast cancer. (8880869)
1996
43
The FHIT and PTPRG genes are deleted in benign proliferative breast disease associated with familial breast cancer and cytogenetic rearrangements of chromosome band 3p14. (8895736)
1996
44
Serum p53 auto-antibodies: incidence in familial breast cancer. (8080669)
1994
45
Familial breast cancer risks. Effects of prostate and other cancers. (8508396)
1993
46
Occurrence of a fetal fibroblast phenotype in familial breast cancer. (3710614)
1986
47
Blood type A and familial breast cancer. (6478419)
1984
48
Familial breast cancer in Iceland. (7085127)
1982
49
Endocrine profile in a patient with familial breast cancer: a case-control study. (498052)
1979
50
Management of familial breast cancer. I. Biostatistical-genetic aspects and their limitations as derived from a familial breast cancer resource. (687103)
1978

Genetic Variations for Familial Breast Cancer

Expression for genes affiliated with Familial Breast Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Familial Breast Cancer

Search GEO for disease gene expression data for Familial Breast Cancer.

Pathways for genes affiliated with Familial Breast Cancer

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 54Reactome
See all sources

Pathways related to Familial Breast Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8MIR125B1, BRCA1, MIR20A, MIR146A, MIR128-2, MIR125A
210.6MIR20A, MIR17, MIR223, MIR27A, MIR24-1
310.6CHEK2, BRCA2, BRCA1
410.6BRCA1, BRCA2, CHEK2
5
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
10.6CHEK2, BRCA2, BRCA1
6
Hide members
10.5BRCA2, BRCA1
710.5CHEK2, BRCA1

Compounds for genes affiliated with Familial Breast Cancer

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Familial Breast Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hydroxyurea45 50 1112.7CHEK2, BRCA2, BRCA1
2adriamycin4510.6CHEK2
3bpde4510.6CHEK2, BRCA1
4camptothecin45 60 1112.6BRCA1, BRCA2, CHEK2
5lycopene45 2411.5BRCA2, BRCA1
68-oxoguanine4510.4BRCA2, BRCA1
7daidzein4510.2BRCA2, BRCA1

GO Terms for genes affiliated with Familial Breast Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Familial Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-strand break repairGO:00630210.6CHEK2, BRCA2, BRCA1
2response to gamma radiationGO:01033210.5CHEK2, BRCA2
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.4BRCA2, BRCA1
4intrinsic apoptotic signaling pathway in response to DNA damageGO:00863010.2CHEK2, BRCA1

Products for genes affiliated with Familial Breast Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Familial Breast Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet