MCID: FML114
MIFTS: 32

Familial Chronic Lymphocytic Leukemia malady

Genetic diseases, Immune diseases, Rare diseases, Cancer diseases, Blood diseases categories

Summaries for Familial Chronic Lymphocytic Leukemia

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MalaCards based summary: Familial Chronic Lymphocytic Leukemia is related to chronic lymphocytic leukemia and leukemia. An important gene associated with Familial Chronic Lymphocytic Leukemia is CD79B (CD79b molecule, immunoglobulin-associated beta), and among its related pathways are Cardiac Progenitor Differentiation and miRNAs involved in DDR. The compounds methylmethanesulfonate and acetic acid have been mentioned in the context of this disorder. Affiliated tissues include b cells, and related mouse phenotypes are cellular and hematopoietic system.

Aliases & Classifications for Familial Chronic Lymphocytic Leukemia

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Familial Chronic Lymphocytic Leukemia, Aliases & Descriptions:

Name: Familial Chronic Lymphocytic Leukemia 20


Classifications:



Related Diseases for Familial Chronic Lymphocytic Leukemia

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Diseases in the Chronic Lymphocytic Leukemia family:

Adult Acute Lymphocytic Leukemia Familial Acute Lymphocytic Leukemia
familial chronic lymphocytic leukemia

Diseases related to Familial Chronic Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
idRelated DiseaseScoreTop Affiliating Genes
1chronic lymphocytic leukemia30.7ATM, TNFSF13B, CXCR4, CD79B, CD38
2leukemia30.1ATM, CXCR4, ANPEP, RAD51, CD2, CD79B
3richter's syndrome10.2
4bilateral breast cancer10.2ATM, RAD51
5werner syndrome10.2RAD54L, ATM
6burkitt lymphoma10.1ANPEP, ATM
7agammaglobulinemia10.1CXCR4, CD38
8human immunodeficiency virus infectious disease10.1CXCR4, CD38
9systemic lupus erythematosus10.1TNFSF13B, CD2, CD38
10b-cell lymphomas10.0ATM, TNFSF13B, CD79B
11bloom syndrome10.0ATM, RAD54L, RAD51
12fanconi anemia, complementation group a10.0ATM, RAD51
13acute lymphoblastic leukemia, childhood10.0ANPEP, ATM
14severe combined immunodeficiency10.0CD38, CXCR4
15prolymphocytic leukemia10.0ATM, ANPEP, CD38
16chromosomal triplication9.9ATM, ANPEP, CD38
17multiple sclerosis, disease progression, modifier of9.9CD2, ANPEP, TNFSF13B
18precursor b-cell acute lymphoblastic leukemia9.9ANPEP, CXCR4
19hiv-19.9CXCR4, CD79B, CD38
20diabetes mellitus, noninsulin-dependent9.9ATM, ANPEP, CD2
21leukemia, acute lymphoblastic9.8CD38, ANPEP, CXCR4
22acute leukemia9.7ANPEP, CXCR4, ATM
23asthma9.7CD38, CXCR4, TNFSF13B
24lymphoma, non-hodgkin9.7ATM, TNFSF13B, CXCR4, CD38
25ovarian cancer, somatic9.6ATM, CXCR4, RAD52, RAD51
26hypersensitivity reaction type ii disease9.6CD38, ANPEP, CXCR4, TNFSF13B
27melanoma9.6ATM, CXCR4, ANPEP, CD2
28lung cancer9.6RAD51, ANPEP, CXCR4
29adenoma9.5ATM, CXCR4, ANPEP, RAD51
30pancreatic cancer9.5ATM, CXCR4, RAD51
31myeloma9.5TNFSF13B, CXCR4, ANPEP, CD79B, CD38
32viral infectious disease9.5CD38, CD2, ANPEP, CXCR4, TNFSF13B
33prostate cancer9.4ATM, CXCR4, ANPEP, RAD51
34breast cancer9.3ATM, CXCR4, ANPEP, RAD52, RAD51
35ipex syndrome9.3ATM, TNFSF13B, CXCR4, ANPEP, CD2, CD38

Graphical network of the top 20 diseases related to Familial Chronic Lymphocytic Leukemia:



Diseases related to familial chronic lymphocytic leukemia

Symptoms for Familial Chronic Lymphocytic Leukemia

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Drugs & Therapeutics for Familial Chronic Lymphocytic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Familial Chronic Lymphocytic Leukemia

Search NIH Clinical Center for Familial Chronic Lymphocytic Leukemia

Genetic Tests for Familial Chronic Lymphocytic Leukemia

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Genetic tests related to Familial Chronic Lymphocytic Leukemia:

id Genetic test Affiliating Genes
1 Familial Chronic Lymphocytic Leukemia20

Anatomical Context for Familial Chronic Lymphocytic Leukemia

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MalaCards organs/tissues related to Familial Chronic Lymphocytic Leukemia:

31
B cells

Animal Models for Familial Chronic Lymphocytic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Familial Chronic Lymphocytic Leukemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.4CXCR4, RAD52, RAD54L, RAD51, CD38, ATM
2MP:00053976.5CD38, ATM, TNFSF13B, CXCR4, ANPEP, RAD52
3MP:00053876.3ATM, TNFSF13B, CXCR4, ANPEP, RAD52, RAD54L

Publications for Familial Chronic Lymphocytic Leukemia

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Articles related to Familial Chronic Lymphocytic Leukemia:

(show all 28)
idTitleAuthorsYear
1
Familial chronic lymphocytic leukemia in Norway and Denmark. Comments on pleiotropy and birth order. (20133982)
2010
2
Familial chronic lymphocytic leukemia. (20389242)
2010
3
The molecular basis of familial chronic lymphocytic leukemia. (19407315)
2009
4
Familial chronic lymphocytic leukemia: what does it mean to me? (19778840)
2009
5
Increased serum BAFF (B-cell activating factor of the TNF family) level is a peculiar feature associated with familial chronic lymphocytic leukemia. (18556064)
2009
6
Familial chronic lymphocytic leukemia. (20425469)
2008
7
Germline mutations in RAD51, RAD51AP1, RAD51B, RAD51C,RAD51D, RAD52 and RAD54L do not contribute to familial chronic lymphocytic leukemia. (18203022)
2008
8
Immunophenotypic features distinguishing familial chronic lymphocytic leukemia from sporadic chronic lymphocytic leukemia. (18431797)
2008
9
Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia. (17047154)
2007
10
Familial chronic lymphocytic leukemia. (16616066)
2006
11
Clinical features and outcome of familial chronic lymphocytic leukemia. (16885053)
2006
12
Identification of a new monoclonal B-cell subset in unaffected first-degree relatives in familial chronic lymphocytic leukemia. (16208408)
2005
13
Perspectives on familial chronic lymphocytic leukemia: genes and the environment. (15269880)
2004
14
Definition and diagnosis of sporadic and familial chronic lymphocytic leukemia. (15325698)
2004
15
Hodgkin's type of Richter's syndrome in familial chronic lymphocytic leukemia treated with cladribine and cyclophosphamide. (12802926)
2003
16
Familial chronic lymphocytic leukemia. (14555317)
2003
17
Telomere length and heavy-chain mutation status in familial chronic lymphocytic leukemia. (12127552)
2002
18
ATM mutations are rare in familial chronic lymphocytic leukemia. (12091354)
2002
19
What are we learning from familial chronic lymphocytic leukemia? (12127549)
2002
20
CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia, but CD38 expression is not. (12150154)
2002
21
Linkage analysis for major histocompatibility complex-related genetic susceptibility in familial chronic lymphocytic leukemia. (11090088)
2000
22
Anticipation in familial chronic lymphocytic leukemia. (10364544)
1999
23
Analysis of the B-cell receptor B29 (CD79b) gene in familial chronic lymphocytic leukemia. (10552962)
1999
24
A clinicopathologic study of familial chronic lymphocytic leukemia. (1546686)
1992
25
Human heavy-chain variable region gene family nonrandomly rearranged in familial chronic lymphocytic leukemia. (3120193)
1987
26
Familial chronic lymphocytic leukemia. (6418939)
1983
27
Familial chronic lymphocytic leukemia. Immunologic and cellular characterization. (818930)
1976
28
Familial chronic lymphocytic leukemia. (4184386)
1969

Variations for Familial Chronic Lymphocytic Leukemia

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Expression for genes affiliated with Familial Chronic Lymphocytic Leukemia

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Search GEO for disease gene expression data for Familial Chronic Lymphocytic Leukemia.

Pathways for genes affiliated with Familial Chronic Lymphocytic Leukemia

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Pathways related to Familial Chronic Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CXCR4, ANPEP
29.3RAD52, ATM
39.2ANPEP, CD2, CD38
49.1RAD51, ATM
5
Show member pathways
ATM Signaling Pathway36
9.1RAD51, ATM
69.1ATM, RAD51
7
Show member pathways
9.1RAD51, ATM
88.8RAD51, RAD54L, ATM
9
Show member pathways
DNA damage response36
8.8RAD51, RAD52, ATM
10
Show member pathways
8.8ATM, RAD52, RAD51
11
Show member pathways
8.8RAD51, RAD52, ATM
12
Show member pathways
8.8ATM, RAD52, RAD51
138.8ATM, RAD52, RAD51
14
Show member pathways
Homologous recombination36
8.4RAD51, RAD54L, RAD52, ATM
15
Show member pathways
7.7ATM, TNFSF13B, CXCR4, RAD51, CD2

Compounds for genes affiliated with Familial Chronic Lymphocytic Leukemia

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Compounds related to Familial Chronic Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 20)
idCompoundScoreTop Affiliating Genes
1methylmethanesulfonate439.8RAD51, RAD52
2acetic acid43 28 24 1212.5RAD51, ANPEP
3rituximab43 49 1211.5CD38, TNFSF13B
4aphidicolin439.4RAD51, ATM
5actinomycin d439.1CD38, ANPEP, CXCR4
6camptothecin43 59 1211.1RAD51, RAD52, ATM
7phosphoinositide438.9ATM, CXCR4, CD79B
8thymidine43 249.9TNFSF13B, RAD51, CD2
9glucose438.8CXCR4, ANPEP, CD2, CD38
10heparin43 28 24 1211.8RAD51, ANPEP, CXCR4
11alanine438.6TNFSF13B, CXCR4, ANPEP, RAD51
12phosphatidylinositol438.6CD38, CD79B, CXCR4, ATM
13threonine438.6ATM, ANPEP, RAD51, CD79B
14lactate438.6ANPEP, CXCR4, ATM
15cisplatin43 49 59 1211.4ATM, CXCR4, RAD52, RAD51
16lipid438.4ATM, ANPEP, CD2, CD38
17calcium43 49 24 1211.1TNFSF13B, CXCR4, ANPEP, CD2, CD79B, CD38
18wortmannin438.0CD2, RAD51, ANPEP, CXCR4, ATM
19atp43 288.6ATM, CXCR4, ANPEP, RAD54L, RAD51, CD38
20tyrosine437.3ATM, CXCR4, ANPEP, RAD51, CD2, CD79B

GO Terms for genes affiliated with Familial Chronic Lymphocytic Leukemia

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Cellular components related to Familial Chronic Lymphocytic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.1CD38, CD2, CXCR4
2external side of plasma membraneGO:00098978.4CD79B, CD2, ANPEP, CXCR4

Biological processes related to Familial Chronic Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1B cell receptor signaling pathwayGO:00508539.9CD38, CD79B
2DNA recombinase assemblyGO:00007309.8RAD51, RAD52
3mitotic recombinationGO:00063129.8RAD52, RAD51
4positive regulation of B cell proliferationGO:00308909.7CD38, TNFSF13B
5DNA recombinationGO:00063109.6RAD51, RAD54L
6response to ionizing radiationGO:00102129.3ATM, RAD54L
7meiotic nuclear divisionGO:00071269.3RAD51, RAD54L
8reciprocal meiotic recombinationGO:00071319.0RAD51, RAD52, ATM
9double-strand break repairGO:00063029.0RAD51, RAD52, ATM
10response to hypoxiaGO:00016668.8CD38, CXCR4, ATM
11double-strand break repair via homologous recombinationGO:00007248.7RAD51, RAD54L, RAD52, ATM
12DNA repairGO:00062818.7ATM, RAD52, RAD54L, RAD51
13signal transductionGO:00071658.4CD38, CD79B, TNFSF13B, ATM

Molecular functions related to Familial Chronic Lymphocytic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1virus receptor activityGO:00016189.0ANPEP, CXCR4
2protein bindingGO:00055157.0CD2, RAD51, RAD54L, RAD52, CXCR4, TNFSF13B

Products for genes affiliated with Familial Chronic Lymphocytic Leukemia

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Sources for Familial Chronic Lymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet