MCID: FML114
MIFTS: 28

Familial Chronic Lymphocytic Leukemia malady

Immune, Genetic categories

Summaries for Familial Chronic Lymphocytic Leukemia

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MalaCards: Familial Chronic Lymphocytic Leukemia is related to b-cell chronic lymphocytic leukemia and richter's syndrome. An important gene associated with Familial Chronic Lymphocytic Leukemia is CD79B (CD79b molecule, immunoglobulin-associated beta), and among its related pathways are Assembly of the RAD51-ssDNA nucleoprotein complex and Fanconi Anemia pathway. The compounds aphidicolin and camptothecin have been mentioned in the context of this disorder. Affiliated tissues include b cells, and related mouse phenotypes are cellular and reproductive system.

Aliases & Classifications for Familial Chronic Lymphocytic Leukemia

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20GeneTests
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Immune


Aliases & Descriptions:

familial chronic lymphocytic leukemia 20


Related Diseases for Familial Chronic Lymphocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Familial Chronic Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell chronic lymphocytic leukemia30.2TNFSF13B, ATM, ANPEP, CD38, CD79B, CXCR4
2richter's syndrome10.2
3leukemia, b-cell, chronic10.2
4leukemia, chronic lymphocytic 110.2
5multiple myeloma10.0CD38
6nijmegen breakage syndrome10.0ATM
7hepatitis10.0ANPEP
8myelodysplastic syndromes10.0ANPEP
9arthritis10.0ANPEP
10sarcoma10.0ANPEP
11werner syndrome10.0RAD54L, ATM
12myeloid leukemia10.0ANPEP, CD38
13colorectal cancer10.0SFRP1, ATM
14severe combined immunodeficiency10.0CD38, CXCR4
15bilateral breast cancer10.0RAD51, ATM
16multiple sclerosis10.0CD2, ANPEP, TNFSF13B
17bloom syndrome10.0RAD54L, RAD51, ATM
18agammaglobulinemia10.0CXCR4, CD38
19b-cell lymphomas10.0TNFSF13B, ATM, CD79B
20prolymphocytic leukemia10.0ATM, ANPEP, CD38
21encephalomyelitis10.0ANPEP, TNFSF13B
22rheumatoid arthritis10.0CXCR4, TNFSF13B, SFRP1
23burkitt's lymphoma10.0CXCR4, CD38, TNFSF13B
24immunodeficiency with hyper igm type 210.0CXCR4, CD79B, CD38
25pancreatic cancer10.0ATM, CXCR4, RAD51
26insulin resistance10.0CD2, ANPEP, ATM
27adenocarcinoma10.0RAD51, CXCR4, ANPEP
28precursor b-cell acute lymphoblastic leukemia10.0CXCR4, ANPEP
29non-hodgkin lymphoma10.0CXCR4, CD38, ATM, TNFSF13B
30acute lymphocytic leukemia10.0ANPEP, CD38, CXCR4
31ovarian cancer10.0ATM, CXCR4, RAD51, RAD52
32chronic lymphocytic leukemia10.0TNFSF13B, ATM, CD38, CD79B, CXCR4
33hypersensitivity reaction type ii disease10.0TNFSF13B, ANPEP, CD38, CXCR4
34viral infectious disease10.0TNFSF13B, ANPEP, CD2, CD38, CXCR4
35malignant glioma10.0SFRP1, ATM, CXCR4, RAD51
36breast cancer10.0ATM, ANPEP, CXCR4, RAD51
37myeloma10.0SFRP1, TNFSF13B, ANPEP, CD38, CD79B, CXCR4
38ipex syndrome10.0TNFSF13B, ATM, ANPEP, CD2, CD38, CXCR4
39adenoma10.0SFRP1, ATM, ANPEP, CXCR4, RAD51
40prostate cancer9.9SFRP4, SFRP1, ATM, ANPEP, CXCR4, RAD51
41leukemia9.9ATM, ANPEP, CD2, CD38, CD79B, CXCR4

Graphical network of the top 20 diseases related to Familial Chronic Lymphocytic Leukemia:



Diseases related to familial chronic lymphocytic leukemia

Clinical Features for Familial Chronic Lymphocytic Leukemia

Drugs & Therapeutics for Familial Chronic Lymphocytic Leukemia

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Familial Chronic Lymphocytic Leukemia

Search CenterWatch for Familial Chronic Lymphocytic Leukemia

Genetic Tests for Familial Chronic Lymphocytic Leukemia

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20GeneTests
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Genetic tests related to Familial Chronic Lymphocytic Leukemia:

id Genetic test Affiliating Genes
1 Familial Chronic Lymphocytic Leukemia20

Anatomical Context for Familial Chronic Lymphocytic Leukemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Familial Chronic Lymphocytic Leukemia:

33
B cells

Animal Models for Familial Chronic Lymphocytic Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Familial Chronic Lymphocytic Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.2TNFSF13B, ATM, CD38, CD79B, CXCR4, RAD51
2MP:00053897.2SFRP1, ATM, ANPEP, CXCR4, RAD52, SFRP4
3MP:00053976.8SFRP1, TNFSF13B, ATM, ANPEP, CD79B, CXCR4
4MP:00053876.6RAD52, SFRP1, TNFSF13B, ATM, ANPEP, CD38

Publications for Familial Chronic Lymphocytic Leukemia

Sources:
51PubMed
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Articles related to Familial Chronic Lymphocytic Leukemia:

(show all 33)
idTitleAuthorsYear
1
Familial chronic lymphocytic leukemia in Norway and Denmark. Comments on pleiotropy and birth order. (20133982)
2010
2
Familial chronic lymphocytic leukemia. (20389242)
2010
3
The molecular basis of familial chronic lymphocytic leukemia. (19407315)
2009
4
Familial chronic lymphocytic leukemia: what does it mean to me? (19778840)
2009
5
Increased serum BAFF (B-cell activating factor of the TNF family) level is a peculiar feature associated with familial chronic lymphocytic leukemia. (18556064)
2009
6
Familial chronic lymphocytic leukemia. (20425469)
2008
7
Germline mutations in RAD51, RAD51AP1, RAD51B, RAD51C,RAD51D, RAD52 and RAD54L do not contribute to familial chronic lymphocytic leukemia. (18203022)
2008
8
Immunophenotypic features distinguishing familial chronic lymphocytic leukemia from sporadic chronic lymphocytic leukemia. (18431797)
2008
9
Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia. (17047154)
2007
10
Familial B-cell chronic lymphocytic leukemia: analysis of cytogenetic abnormalities, immunophenotypic profiles, and immunoglobulin heavy chain gene usage. (17145621)
2007
11
Familial chronic lymphocytic leukemia. (16616066)
2006
12
Clinical features and outcome of familial chronic lymphocytic leukemia. (16885053)
2006
13
Identification of a new monoclonal B-cell subset in unaffected first-degree relatives in familial chronic lymphocytic leukemia. (16208408)
2005
14
Perspectives on familial chronic lymphocytic leukemia: genes and the environment. (15269880)
2004
15
Familial B-cell chronic lymphocytic leukemia in a population of patients from Southern Italy. (15218964)
2004
16
The P2X7 receptor gene A1513C polymorphism does not contribute to risk of familial or sporadic chronic lymphocytic leukemia. (15184265)
2004
17
Definition and diagnosis of sporadic and familial chronic lymphocytic leukemia. (15325698)
2004
18
Hodgkin's type of Richter's syndrome in familial chronic lymphocytic leukemia treated with cladribine and cyclophosphamide. (12802926)
2003
19
Cytogenetic findings in familial B-cell chronic lymphocytic leukemia: a report of two cases in a family. (12781453)
2003
20
Familial chronic lymphocytic leukemia. (14555317)
2003
21
B-cell monoclonal lymphocytosis and B-cell abnormalities in the setting of familial B-cell chronic lymphocytic leukemia. (12599176)
2003
22
Telomere length and heavy-chain mutation status in familial chronic lymphocytic leukemia. (12127552)
2002
23
ATM mutations are rare in familial chronic lymphocytic leukemia. (12091354)
2002
24
What are we learning from familial chronic lymphocytic leukemia? (12127549)
2002
25
CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia, but CD38 expression is not. (12150154)
2002
26
Linkage analysis for major histocompatibility complex-related genetic susceptibility in familial chronic lymphocytic leukemia. (11090088)
2000
27
Anticipation in familial chronic lymphocytic leukemia. (10364544)
1999
28
Analysis of the B-cell receptor B29 (CD79b) gene in familial chronic lymphocytic leukemia. (10552962)
1999
29
A clinicopathologic study of familial chronic lymphocytic leukemia. (1546686)
1992
30
Human heavy-chain variable region gene family nonrandomly rearranged in familial chronic lymphocytic leukemia. (3120193)
1987
31
Familial chronic lymphocytic leukemia. (6418939)
1983
32
Familial chronic lymphocytic leukemia. Immunologic and cellular characterization. (818930)
1976
33
Familial chronic lymphocytic leukemia. (4184386)
1969

Genetic Variations for Familial Chronic Lymphocytic Leukemia

Expression for genes affiliated with Familial Chronic Lymphocytic Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Chronic Lymphocytic Leukemia

Search GEO for disease gene expression data for Familial Chronic Lymphocytic Leukemia.

Pathways for genes affiliated with Familial Chronic Lymphocytic Leukemia

Sources:
54Reactome, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 30KEGG, 4Cell Signaling Technology
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Compounds for genes affiliated with Familial Chronic Lymphocytic Leukemia

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 29IUPHAR, 24HMDB
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Compounds related to Familial Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aphidicolin459.5RAD51, ATM
2camptothecin45 60 1111.2ATM, RAD51, RAD52
3cisplatin45 50 60 1111.6RAD52, RAD51, CXCR4, ATM
4heparin45 29 11 2411.5SFRP1, CXCR4, RAD51
5wortmannin458.4ATM, ANPEP, CD2, CXCR4, RAD51
6calcium45 50 11 2411.2SFRP4, TNFSF13B, ANPEP, CD2, CD38, CD79B
7atp45 299.1ATM, ANPEP, CD38, CXCR4, RAD51, RAD54L
8tyrosine457.0RAD51, SFRP1, ATM, ANPEP, CD2, CD38

GO Terms for genes affiliated with Familial Chronic Lymphocytic Leukemia

Sources:
16Gene Ontology
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Cellular components related to Familial Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6CXCR4, CD79B, CD2, ANPEP
2cell surfaceGO:0099868.2CXCR4, CD38, SFRP1, SFRP4

Biological processes related to Familial Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1DNA recombinase assemblyGO:0007309.9RAD51, RAD52
2mitotic recombinationGO:0063129.9RAD51, RAD52
3B cell receptor signaling pathwayGO:0508539.8CD79B, CD38
4response to ionizing radiationGO:0102129.7RAD54L, ATM
5positive regulation of B cell proliferationGO:0308909.5CD38, TNFSF13B
6reciprocal meiotic recombinationGO:0071319.4RAD52, RAD51, ATM
7double-strand break repairGO:0063029.4RAD52, RAD51, ATM
8menstrual cycle phaseGO:0226019.3SFRP1, SFRP4
9response to hypoxiaGO:0016669.3CXCR4, ATM, CD38
10double-strand break repair via homologous recombinationGO:0007249.2RAD52, RAD54L, RAD51, ATM
11vasculature developmentGO:0019449.1SFRP1, SFRP4
12DNA repairGO:0062819.0ATM, RAD51, RAD54L, RAD52
13gonad developmentGO:0084069.0SFRP4, SFRP1
14brain developmentGO:0074208.3CXCR4, ATM, SFRP1, SFRP4

Molecular functions related to Familial Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1virus receptor activityGO:0016189.5CXCR4, ANPEP
2Wnt-activated receptor activityGO:0428138.9SFRP1, SFRP4
3Wnt-protein bindingGO:0171478.7SFRP1, SFRP4

Products for genes affiliated with Familial Chronic Lymphocytic Leukemia

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Sources for Familial Chronic Lymphocytic Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet