MCID: FML114
MIFTS: 38

Familial Chronic Lymphocytic Leukemia malady

Genetic diseases, Immune diseases, Rare diseases, Cancer diseases, Blood diseases categories

Summaries for Familial Chronic Lymphocytic Leukemia

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MalaCards: Familial Chronic Lymphocytic Leukemia is related to chronic lymphocytic leukemia and leukemia. An important gene associated with Familial Chronic Lymphocytic Leukemia is CD79B (CD79b molecule, immunoglobulin-associated beta), and among its related pathways are Cardiac Progenitor Differentiation and miRNAs involved in DDR. The compounds methylmethanesulfonate and acetic acid have been mentioned in the context of this disorder. Affiliated tissues include b cells, and related mouse phenotypes are cellular and hematopoietic system.

Aliases & Classifications for Familial Chronic Lymphocytic Leukemia

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Classifications:



Aliases & Descriptions:

familial chronic lymphocytic leukemia 21


Related Diseases for Familial Chronic Lymphocytic Leukemia

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18GeneCards, 19GeneDecks
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Diseases in the Acute Lymphocytic Leukemia family:

Adult Acute Lymphocytic Leukemia Chronic Lymphocytic Leukemia
Familial Acute Lymphocytic Leukemia familial chronic lymphocytic leukemia
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 3
Leukemia, Acute Lymphocytic 1 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 5 Leukemia, Chronic Lymphocytic 2

Diseases related to Familial Chronic Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 35)
idRelated DiseaseScoreTop Affiliating Genes
1chronic lymphocytic leukemia31.2ATM, TNFSF13B, CXCR4, CD79B, CD38
2leukemia31.1ATM, CXCR4, ANPEP, RAD51, CD2, CD79B
3richter's syndrome10.2
4bilateral breast cancer10.0ATM, RAD51
5werner syndrome10.0RAD54L, ATM
6burkitt's lymphoma10.0ANPEP, ATM
7agammaglobulinemia10.0CXCR4, CD38
8human immunodeficiency virus infectious disease10.0CXCR4, CD38
9systemic lupus erythematosus10.0TNFSF13B, CD2, CD38
10b-cell lymphomas10.0ATM, TNFSF13B, CD79B
11bloom syndrome10.0ATM, RAD54L, RAD51
12fanconi's anemia10.0ATM, RAD51
13acute lymphoblastic leukemia, childhood10.0ANPEP, ATM
14severe combined immunodeficiency10.0CD38, CXCR4
15prolymphocytic leukemia10.0ATM, ANPEP, CD38
16multiple sclerosis10.0CD2, ANPEP, TNFSF13B
17leukemia, acute lymphoblastic 310.0ANPEP, CXCR4
18immunodeficiency with hyper igm type 210.0CXCR4, CD79B, CD38
19insulin resistance10.0ATM, ANPEP, CD2
20acute lymphocytic leukemia9.9CD38, ANPEP, CXCR4
21acute leukemia9.9ANPEP, CXCR4, ATM
22asthma9.9CD38, CXCR4, TNFSF13B
23non-hodgkin lymphoma9.9ATM, TNFSF13B, CXCR4, CD38
24ovarian cancer9.9ATM, CXCR4, RAD52, RAD51
25hypersensitivity reaction type ii disease9.9CD38, ANPEP, CXCR4, TNFSF13B
26melanoma9.9ATM, CXCR4, ANPEP, CD2
27non-small cell lung carcinoma9.9RAD51, ANPEP, CXCR4
28adenoma9.9ATM, CXCR4, ANPEP, RAD51
29pancreatic cancer9.9ATM, CXCR4, RAD51
30myeloma9.9TNFSF13B, CXCR4, ANPEP, CD79B, CD38
31viral infectious disease9.9CD38, CD2, ANPEP, CXCR4, TNFSF13B
32prostate cancer9.9ATM, CXCR4, ANPEP, RAD51
33breast cancer9.8ATM, CXCR4, ANPEP, RAD52, RAD51
34ipex syndrome9.8ATM, TNFSF13B, CXCR4, ANPEP, CD2, CD38
35b-cell chronic lymphocytic leukemia9.8CD38, ATM, TNFSF13B, CXCR4, ANPEP, RAD51

Graphical network of the top 20 diseases related to Familial Chronic Lymphocytic Leukemia:



Diseases related to familial chronic lymphocytic leukemia

Symptoms for Familial Chronic Lymphocytic Leukemia

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Drugs & Therapeutics for Familial Chronic Lymphocytic Leukemia

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Familial Chronic Lymphocytic Leukemia

Genetic Tests for Familial Chronic Lymphocytic Leukemia

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21GeneTests
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Genetic tests related to Familial Chronic Lymphocytic Leukemia:

id Genetic test Affiliating Genes
1 Familial Chronic Lymphocytic Leukemia21

Anatomical Context for Familial Chronic Lymphocytic Leukemia

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34MalaCards
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MalaCards organs/tissues related to Familial Chronic Lymphocytic Leukemia:

34
B cells

Animal Models for Familial Chronic Lymphocytic Leukemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Familial Chronic Lymphocytic Leukemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.4CXCR4, RAD52, RAD54L, RAD51, CD38, ATM
2MP:00053976.5CD38, ATM, TNFSF13B, CXCR4, ANPEP, RAD52
3MP:00053876.3ATM, TNFSF13B, CXCR4, ANPEP, RAD52, RAD54L

Publications for Familial Chronic Lymphocytic Leukemia

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53PubMed
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Articles related to Familial Chronic Lymphocytic Leukemia:

(show all 28)
idTitleAuthorsYear
1
Familial chronic lymphocytic leukemia in Norway and Denmark. Comments on pleiotropy and birth order. (20133982)
2010
2
Familial chronic lymphocytic leukemia. (20389242)
2010
3
The molecular basis of familial chronic lymphocytic leukemia. (19407315)
2009
4
Familial chronic lymphocytic leukemia: what does it mean to me? (19778840)
2009
5
Increased serum BAFF (B-cell activating factor of the TNF family) level is a peculiar feature associated with familial chronic lymphocytic leukemia. (18556064)
2009
6
Familial chronic lymphocytic leukemia. (20425469)
2008
7
Germline mutations in RAD51, RAD51AP1, RAD51B, RAD51C,RAD51D, RAD52 and RAD54L do not contribute to familial chronic lymphocytic leukemia. (18203022)
2008
8
Immunophenotypic features distinguishing familial chronic lymphocytic leukemia from sporadic chronic lymphocytic leukemia. (18431797)
2008
9
Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia. (17047154)
2007
10
Familial chronic lymphocytic leukemia. (16616066)
2006
11
Clinical features and outcome of familial chronic lymphocytic leukemia. (16885053)
2006
12
Identification of a new monoclonal B-cell subset in unaffected first-degree relatives in familial chronic lymphocytic leukemia. (16208408)
2005
13
Perspectives on familial chronic lymphocytic leukemia: genes and the environment. (15269880)
2004
14
Definition and diagnosis of sporadic and familial chronic lymphocytic leukemia. (15325698)
2004
15
Hodgkin's type of Richter's syndrome in familial chronic lymphocytic leukemia treated with cladribine and cyclophosphamide. (12802926)
2003
16
Familial chronic lymphocytic leukemia. (14555317)
2003
17
Telomere length and heavy-chain mutation status in familial chronic lymphocytic leukemia. (12127552)
2002
18
ATM mutations are rare in familial chronic lymphocytic leukemia. (12091354)
2002
19
What are we learning from familial chronic lymphocytic leukemia? (12127549)
2002
20
CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia, but CD38 expression is not. (12150154)
2002
21
Linkage analysis for major histocompatibility complex-related genetic susceptibility in familial chronic lymphocytic leukemia. (11090088)
2000
22
Anticipation in familial chronic lymphocytic leukemia. (10364544)
1999
23
Analysis of the B-cell receptor B29 (CD79b) gene in familial chronic lymphocytic leukemia. (10552962)
1999
24
A clinicopathologic study of familial chronic lymphocytic leukemia. (1546686)
1992
25
Human heavy-chain variable region gene family nonrandomly rearranged in familial chronic lymphocytic leukemia. (3120193)
1987
26
Familial chronic lymphocytic leukemia. (6418939)
1983
27
Familial chronic lymphocytic leukemia. Immunologic and cellular characterization. (818930)
1976
28
Familial chronic lymphocytic leukemia. (4184386)
1969

Variations for Familial Chronic Lymphocytic Leukemia

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Expression for genes affiliated with Familial Chronic Lymphocytic Leukemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Chronic Lymphocytic Leukemia

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Pathways for genes affiliated with Familial Chronic Lymphocytic Leukemia

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51PathCards, 39NCBI BioSystems Database, 13EMD Millipore, 31KEGG, 61Thomson Reuters, 54QIAGEN, 56Reactome, 5Cell Signaling Technology
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Pathways related to Familial Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CXCR4, ANPEP
29.3RAD52, ATM
39.2RAD51, RAD54L, RAD52
49.2ANPEP, CD2, CD38
59.1RAD51, ATM
6
Show member pathways
ATM Signaling Pathway39
9.1RAD51, ATM
79.1ATM, RAD51
8
Show member pathways
9.1RAD51, ATM
98.8RAD51, RAD54L, ATM
10
Show member pathways
DNA damage response39
8.8RAD51, RAD52, ATM
11
Show member pathways
8.8ATM, RAD52, RAD51
12
Show member pathways
8.8RAD51, RAD52, ATM
13
Show member pathways
8.8ATM, RAD52, RAD51
148.8ATM, RAD52, RAD51
15
Show member pathways
Homologous recombination39
8.4RAD51, RAD54L, RAD52, ATM
16
Show member pathways
7.7ATM, TNFSF13B, CXCR4, RAD51, CD2

Compounds for genes affiliated with Familial Chronic Lymphocytic Leukemia

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46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Familial Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1methylmethanesulfonate469.8RAD51, RAD52
2acetic acid46 30 25 1212.5RAD51, ANPEP
3rituximab46 52 1211.5CD38, TNFSF13B
4aphidicolin469.4RAD51, ATM
5actinomycin d469.1CD38, ANPEP, CXCR4
6camptothecin46 62 1211.1RAD51, RAD52, ATM
7phosphoinositide468.9ATM, CXCR4, CD79B
8thymidine46 259.9TNFSF13B, RAD51, CD2
9glucose468.8CXCR4, ANPEP, CD2, CD38
10heparin46 30 25 1211.8RAD51, ANPEP, CXCR4
11alanine468.6TNFSF13B, CXCR4, ANPEP, RAD51
12phosphatidylinositol468.6CD38, CD79B, CXCR4, ATM
13threonine468.6ATM, ANPEP, RAD51, CD79B
14lactate468.6ANPEP, CXCR4, ATM
15cisplatin46 52 62 1211.4ATM, CXCR4, RAD52, RAD51
16lipid468.4ATM, ANPEP, CD2, CD38
17calcium46 52 25 1211.1TNFSF13B, CXCR4, ANPEP, CD2, CD79B, CD38
18wortmannin468.0CD2, RAD51, ANPEP, CXCR4, ATM
19atp46 308.6ATM, CXCR4, ANPEP, RAD54L, RAD51, CD38
20tyrosine467.3ATM, CXCR4, ANPEP, RAD51, CD2, CD79B

GO Terms for genes affiliated with Familial Chronic Lymphocytic Leukemia

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17Gene Ontology
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Cellular components related to Familial Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.1CD38, CD2, CXCR4
2external side of plasma membraneGO:0098978.4CD79B, CD2, ANPEP, CXCR4

Biological processes related to Familial Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1B cell receptor signaling pathwayGO:0508539.9CD38, CD79B
2DNA recombinase assemblyGO:0007309.8RAD51, RAD52
3mitotic recombinationGO:0063129.8RAD52, RAD51
4positive regulation of B cell proliferationGO:0308909.7CD38, TNFSF13B
5DNA recombinationGO:0063109.6RAD51, RAD54L
6response to ionizing radiationGO:0102129.3ATM, RAD54L
7meiotic nuclear divisionGO:0071269.3RAD51, RAD54L
8reciprocal meiotic recombinationGO:0071319.0RAD51, RAD52, ATM
9double-strand break repairGO:0063029.0RAD51, RAD52, ATM
10response to hypoxiaGO:0016668.8CD38, CXCR4, ATM
11double-strand break repair via homologous recombinationGO:0007248.7RAD51, RAD54L, RAD52, ATM
12DNA repairGO:0062818.7ATM, RAD52, RAD54L, RAD51
13signal transductionGO:0071658.4CD38, CD79B, TNFSF13B, ATM

Molecular functions related to Familial Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1virus receptor activityGO:0016189.0ANPEP, CXCR4
2protein bindingGO:0055157.0CD2, RAD51, RAD54L, RAD52, CXCR4, TNFSF13B

Products for genes affiliated with Familial Chronic Lymphocytic Leukemia

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Sources for Familial Chronic Lymphocytic Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet