MCID: FML114
MIFTS: 27

Familial Chronic Lymphocytic Leukemia malady

Immune diseases, Genetic diseases categories

Summaries for Familial Chronic Lymphocytic Leukemia

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Familial Chronic Lymphocytic Leukemia is related to chronic lymphocytic leukemia and leukemia. An important gene associated with Familial Chronic Lymphocytic Leukemia is CD79B (CD79b molecule, immunoglobulin-associated beta), and among its related pathways are Assembly of the RAD51-ssDNA nucleoprotein complex and Fanconi Anemia pathway. The compounds aphidicolin and camptothecin have been mentioned in the context of this disorder. Related mouse phenotypes are cellular and reproductive system.

Aliases & Classifications for Familial Chronic Lymphocytic Leukemia

About this section
Sources:
20GeneTests
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Immune diseases


Aliases & Descriptions:

familial chronic lymphocytic leukemia 20


Related Diseases for Familial Chronic Lymphocytic Leukemia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Acute Lymphocytic Leukemia family:

Adult Acute Lymphocytic Leukemia Chronic Lymphocytic Leukemia
Familial Acute Lymphocytic Leukemia familial chronic lymphocytic leukemia
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 3
Leukemia, Acute Lymphocytic 1 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 5 Leukemia, Chronic Lymphocytic 2

Diseases related to Familial Chronic Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1chronic lymphocytic leukemia31.3TNFSF13B, ATM, CD38, CD79B, CXCR4
2leukemia31.3ATM, ANPEP, CD2, CD38, CD79B, CXCR4
3richter's syndrome10.2
4multiple myeloma10.0CD38
5nijmegen breakage syndrome10.0ATM
6hepatitis10.0ANPEP
7myelodysplastic syndromes10.0ANPEP
8arthritis10.0ANPEP
9sarcoma10.0ANPEP
10werner syndrome10.0RAD54L, ATM
11myeloid leukemia10.0ANPEP, CD38
12colorectal cancer10.0SFRP1, ATM
13severe combined immunodeficiency10.0CD38, CXCR4
14bilateral breast cancer10.0RAD51, ATM
15multiple sclerosis10.0CD2, ANPEP, TNFSF13B
16bloom syndrome10.0RAD54L, RAD51, ATM
17agammaglobulinemia10.0CXCR4, CD38
18burkitt's lymphoma10.0ANPEP, ATM
19b-cell lymphomas10.0TNFSF13B, ATM, CD79B
20prolymphocytic leukemia10.0ATM, ANPEP, CD38
21encephalomyelitis10.0ANPEP, TNFSF13B
22rheumatoid arthritis10.0CXCR4, TNFSF13B, SFRP1
23immunodeficiency with hyper igm type 210.0CXCR4, CD79B, CD38
24pancreatic cancer10.0ATM, CXCR4, RAD51
25insulin resistance10.0CD2, ANPEP, ATM
26adenocarcinoma10.0RAD51, CXCR4, ANPEP
27precursor b-cell acute lymphoblastic leukemia10.0CXCR4, ANPEP
28non-hodgkin lymphoma10.0CXCR4, CD38, ATM, TNFSF13B
29acute lymphocytic leukemia10.0ANPEP, CD38, CXCR4
30ovarian cancer10.0ATM, CXCR4, RAD51, RAD52
31hypersensitivity reaction type ii disease10.0TNFSF13B, ANPEP, CD38, CXCR4
32viral infectious disease10.0TNFSF13B, ANPEP, CD2, CD38, CXCR4
33malignant glioma10.0SFRP1, ATM, CXCR4, RAD51
34breast cancer10.0ATM, ANPEP, CXCR4, RAD51
35myeloma10.0SFRP1, TNFSF13B, ANPEP, CD38, CD79B, CXCR4
36ipex syndrome10.0TNFSF13B, ATM, ANPEP, CD2, CD38, CXCR4
37adenoma10.0SFRP1, ATM, ANPEP, CXCR4, RAD51
38prostate cancer9.9SFRP4, SFRP1, ATM, ANPEP, CXCR4, RAD51
39b-cell chronic lymphocytic leukemia9.9TNFSF13B, ATM, ANPEP, CD38, CD79B, CXCR4

Graphical network of the top 20 diseases related to Familial Chronic Lymphocytic Leukemia:



Diseases related to familial chronic lymphocytic leukemia

Clinical Features for Familial Chronic Lymphocytic Leukemia

About this section

Drugs & Therapeutics for Familial Chronic Lymphocytic Leukemia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Familial Chronic Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Familial Chronic Lymphocytic Leukemia

Search NIH Clinical Center for Familial Chronic Lymphocytic Leukemia

Search CenterWatch for Familial Chronic Lymphocytic Leukemia

Genetic Tests for Familial Chronic Lymphocytic Leukemia

About this section
Sources:
20GeneTests
See all sources

Genetic tests related to Familial Chronic Lymphocytic Leukemia:

id Genetic test Affiliating Genes
1 Familial Chronic Lymphocytic Leukemia20

Anatomical Context for Familial Chronic Lymphocytic Leukemia

About this section

Animal Models for Familial Chronic Lymphocytic Leukemia or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Familial Chronic Lymphocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.2TNFSF13B, ATM, CD38, CD79B, CXCR4, RAD51
2MP:00053897.2SFRP1, ATM, ANPEP, CXCR4, RAD52, SFRP4
3MP:00053976.8SFRP1, TNFSF13B, ATM, ANPEP, CD79B, CXCR4
4MP:00053876.6RAD52, SFRP1, TNFSF13B, ATM, ANPEP, CD38

Publications for Familial Chronic Lymphocytic Leukemia

About this section

Genetic Variations for Familial Chronic Lymphocytic Leukemia

About this section

Expression for genes affiliated with Familial Chronic Lymphocytic Leukemia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Familial Chronic Lymphocytic Leukemia

Search GEO for disease gene expression data for Familial Chronic Lymphocytic Leukemia.

Pathways for genes affiliated with Familial Chronic Lymphocytic Leukemia

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Familial Chronic Lymphocytic Leukemia

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB
See all sources

Compounds related to Familial Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aphidicolin449.5RAD51, ATM
2camptothecin44 59 1111.2ATM, RAD51, RAD52
3cisplatin44 49 59 1111.6RAD52, RAD51, CXCR4, ATM
4heparin44 28 11 2411.5SFRP1, CXCR4, RAD51
5wortmannin448.4ATM, ANPEP, CD2, CXCR4, RAD51
6calcium44 49 11 2411.2SFRP4, TNFSF13B, ANPEP, CD2, CD38, CD79B
7atp44 289.1ATM, ANPEP, CD38, CXCR4, RAD51, RAD54L
8tyrosine447.0RAD51, SFRP1, ATM, ANPEP, CD2, CD38

GO Terms for genes affiliated with Familial Chronic Lymphocytic Leukemia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Familial Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6CXCR4, CD79B, CD2, ANPEP
2cell surfaceGO:0099868.2CXCR4, CD38, SFRP1, SFRP4

Biological processes related to Familial Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1DNA recombinase assemblyGO:0007309.9RAD52, RAD51
2mitotic recombinationGO:0063129.9RAD51, RAD52
3B cell receptor signaling pathwayGO:0508539.8CD79B, CD38
4response to ionizing radiationGO:0102129.7RAD54L, ATM
5positive regulation of B cell proliferationGO:0308909.5CD38, TNFSF13B
6reciprocal meiotic recombinationGO:0071319.4RAD52, RAD51, ATM
7double-strand break repairGO:0063029.4ATM, RAD51, RAD52
8menstrual cycle phaseGO:0226019.3SFRP1, SFRP4
9response to hypoxiaGO:0016669.3CXCR4, CD38, ATM
10double-strand break repair via homologous recombinationGO:0007249.2RAD52, RAD54L, RAD51, ATM
11vasculature developmentGO:0019449.1SFRP4, SFRP1
12DNA repairGO:0062819.0RAD52, RAD54L, RAD51, ATM
13gonad developmentGO:0084069.0SFRP1, SFRP4
14brain developmentGO:0074208.3SFRP4, SFRP1, ATM, CXCR4

Molecular functions related to Familial Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1virus receptor activityGO:0016189.5CXCR4, ANPEP
2Wnt-activated receptor activityGO:0428138.9SFRP1, SFRP4
3Wnt-protein bindingGO:0171478.7SFRP1, SFRP4

Products for genes affiliated with Familial Chronic Lymphocytic Leukemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Familial Chronic Lymphocytic Leukemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet