MCID: FML053
MIFTS: 39

Familial Colorectal Cancer malady

Cancer diseases, Genetic diseases categories

Summaries for Familial Colorectal Cancer

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32MalaCards
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MalaCards: Familial Colorectal Cancer, also known as colorectal cancer, familial, is related to colorectal cancer and lynch syndrome. An important gene associated with Familial Colorectal Cancer is ARL11 (ADP-ribosylation factor-like 11), and among its related pathways are Fluoropyrimidine Pathway, Pharmacodynamics and Lagging Strand Synthesis. The compounds 5-hydroxymethyluracil and af/ap have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and hematopoietic system.

Aliases & Classifications for Familial Colorectal Cancer

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42NIH Rare Diseases, 22GTR, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases


Aliases & Descriptions:

familial colorectal cancer 42
colorectal cancer, familial 42 22
hereditary malignant neoplasm 60


Related Diseases for Familial Colorectal Cancer

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17GeneCards, 18GeneDecks
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Diseases in the Colorectal Cancer family:

familial colorectal cancer Colorectal Cancer 6
Colorectal Cancer 2 Colorectal Cancer 1
Colorectal Cancer 5 Colorectal Cancer 7
Colorectal Cancer 12 Colorectal Cancer 8
Colorectal Cancer 4 Colorectal Cancer 9
Colorectal Cancer 3 Colorectal Cancer 10
Colorectal Cancer 11

Diseases related to Familial Colorectal Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer31.7APC, PMS1, TIMP3, BAK1, MUTYH, MSH2
2lynch syndrome30.8MSH2, PMS1
3colon cancer30.7PMS1, TIMP3, MSH2, MUTYH, BAK1, APC
4adenoma30.5TIMP3, MSH2, BAK1, APC, MUTYH
5peutz-jeghers syndrome30.1PMS1, APC
6familial adenomatous polyposis30.1MSH2, MUTYH, PMS1, APC
7ovarian cancer30.1MPG, MSH2, SMUG1, PMS1, SMAD7, TIMP3
8retinal cancer10.2
9retinitis10.2
10brachydactyly10.1
11mandibular cancer10.1
12juvenile polyposis syndrome10.1
13inflammatory bowel disease10.1
14colorectal cancer, hereditary nonpolyposis, type 110.1
15familial prostate cancer10.0
16stomach cancer, familial10.0
17gastric cancer risk after h. pylori infection10.0
18muir-torre syndrome10.0MSH2
19multiple sclerosis10.0TIMP3
20stomach cancer10.0APC, MUTYH
21leukemia10.0BAK1, MSH2
22esophageal cancer10.0SMUG1
23rectal neoplasm10.0APC, MSH2, MUTYH
24colorectal cancer, somatic10.0MLH3, APC
25glioblastoma multiforme10.0BAK1, UNG, TIMP3
26gastric cancer, somatic10.0MUTYH, APC
27pancreatic cancer10.0SMAD7, SMUG1, MSH2, BAK1
28cervical cancer10.0SMUG1, MSH2, BAK1, TIMP3
29cholangiocarcinoma10.0TIMP3
30adenocarcinoma10.0MSH2, TIMP3, APC, BAK1, SMAD7
31melanoma10.0SMUG1, MSH2, EPHB6, BAK1, TIMP3, PMS1
32prostate cancer10.0PMS1, SMAD7, MSH2, BAK1, TIMP3, APC
33turcot syndrome10.0APC, PMS1
34thyroid cancer10.0APC, BAK1, TIMP3
35lung cancer10.0MPG, MUTYH, SMAD7, TDG, BAK1, UNG
36malignant glioma10.0PMS1, TIMP3, BAK1, UNG, SMAD7, MPG
37squamous cell carcinoma10.0MSH2, APC, PMS1, BAK1, SMAD7, TIMP3
38breast cancer10.0PMS1, TIMP3, APC, MPG, SMAD7, BAK1
39hepatocellular carcinoma10.0SMAD7, APC, TIMP3, BAK1, MUTYH
40gallbladder cancer10.0APC
41burkitt's lymphoma10.0MSH2, PMS1, BAK1, SMUG1, SMAD7

Graphical network of the top 20 diseases related to Familial Colorectal Cancer:



Diseases related to familial colorectal cancer

Clinical Features for Familial Colorectal Cancer

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Drugs & Therapeutics for Familial Colorectal Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Familial Colorectal Cancer

Search CenterWatch for Familial Colorectal Cancer

Genetic Tests for Familial Colorectal Cancer

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22GTR
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Genetic tests related to Familial Colorectal Cancer:

id Genetic test Affiliating Genes
1 Familial Colorectal Cancer22

Anatomical Context for Familial Colorectal Cancer

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Animal Models for Familial Colorectal Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Familial Colorectal Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.2PMS1, UNG, EPHB6, MSH2
2MP:00053979.8SMAD7, MSH2, APC, EPHB6, TIMP3, MPG
3MP:00053849.5MUTYH, TDG, TIMP3, APC, UNG, MPG
4MP:00053769.5EPHB6, SLC10A2, MSH2, SMUG1, SMAD7, TDG
5MP:00053879.5SMAD7, MSH2, EPHB6, BAK1, TIMP3, UNG

Publications for Familial Colorectal Cancer

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Genetic Variations for Familial Colorectal Cancer

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Expression for genes affiliated with Familial Colorectal Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Colorectal Cancer

Search GEO for disease gene expression data for Familial Colorectal Cancer.

Pathways for genes affiliated with Familial Colorectal Cancer

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Sources:
49PharmGKB, 53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Familial Colorectal Cancer

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Sources:
44Novoseek, 59Tocris Bioscience, 24HMDB, 11DrugBank, 49PharmGKB
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Compounds related to Familial Colorectal Cancer according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
15-hydroxymethyluracil4410.6SMUG1, UNG
2af/ap4410.6MUTYH, APC
35-formyluracil4410.6SMUG1, UNG
45-hydroxyuracil4410.6SMUG1, NEIL1, UNG
53,n(4)-ethenocytosine4410.6TDG, MPG
6mnng4410.6APC, MPG, MSH2
78-oxoguanine4410.5APC, MPG, NEIL1, MUTYH
83-methyladenine44 59 2412.5MPG, UNG
9thymine44 2411.5APC, UNG, TDG
10o6-methylguanine4410.5TIMP3, APC, MPG, MSH2
11pyrimidine44 2411.5MPG, MUTYH, SMUG1
12oligodeoxyribonucleotides4410.5MPG, UNG
13sodium bisulfite4410.4APC, UNG
14guanine44 11 2412.4TDG, MUTYH, MPG, UNG, APC
15mononucleotide4410.4APC, MSH2
16cytosine44 2411.4TDG, SMUG1, NEIL1, MPG, UNG, APC
17adenine44 11 2412.4APC, UNG, MPG, MUTYH, MSH2, TDG
185fluorouracil4410.3TDG, MSH2, BAK1, UNG
19cisplatin44 49 59 1113.3UNG, MPG, BAK1, MSH2, SMAD7
205-methylcytosine44 2411.3TDG, APC
21oligonucleotide4410.3TIMP3, APC, UNG, MPG, NEIL1, SMAD7
22chlorambucil44 1111.2BAK1, MPG
23paraffin4410.1TIMP3, APC, BAK1, MSH2
24polynucleotide4410.0NEIL1, UNG

GO Terms for genes affiliated with Familial Colorectal Cancer

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16Gene Ontology
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Cellular components related to Familial Colorectal Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mismatch repair complexGO:03230010.0PMS1, MLH3
2nucleusGO:0056349.6C10orf137, PMS1, APC, UNG, MLH3, NEIL2

Biological processes related to Familial Colorectal Cancer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1depurinationGO:04500710.4MUTYH, MPG
2base-excision repair, AP site formationGO:00628510.3TDG, SMUG1, MUTYH, MPG
3depyrimidinationGO:04500810.3SMUG1, TDG
4negative regulation of peptidyl-serine phosphorylationGO:03313710.3SMAD7, BAK1
5mismatch repairGO:00629810.3PMS1, MLH3, MUTYH, MSH2, TDG
6somatic recombination of immunoglobulin gene segmentsGO:01644710.2UNG, MSH2
7base-excision repairGO:00628410.2TDG, SMUG1, MUTYH, NEIL1, NEIL2, MPG
8DNA repairGO:00628110.1UNG, MPG, MUTYH, MSH2, SMUG1, TDG
9somatic hypermutation of immunoglobulin genesGO:01644610.0MSH2, UNG

Molecular functions related to Familial Colorectal Cancer according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1uracil DNA N-glycosylase activityGO:00484410.5SMUG1, UNG
2DNA N-glycosylase activityGO:01910410.5TDG, SMUG1, NEIL1
3MutLalpha complex bindingGO:03240510.5MUTYH, MSH2
4MutSalpha complex bindingGO:03240710.4MUTYH, MLH3, PMS1
5centromeric DNA bindingGO:01923710.4MLH3, MSH2
6mismatched DNA bindingGO:03098310.4MLH3, TDG, MSH2, PMS1
7damaged DNA bindingGO:00368410.4TDG, MPG, NEIL2, NEIL1
8hydrolase activity, acting on glycosyl bondsGO:01679810.3MUTYH, NEIL1
9single-stranded DNA bindingGO:00369710.2MLH3, PMS1, MSH2
10ATPase activityGO:01688710.2MLH3, MSH2, PMS1
11DNA-(apurinic or apyrimidinic site) lyase activityGO:00390610.0NEIL1, NEIL2

Products for genes affiliated with Familial Colorectal Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Familial Colorectal Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet