MCID: FML020
MIFTS: 63

Familial Combined Hyperlipidemia malady

Metabolic diseases, Genetic diseases categories

Summaries for Familial Combined Hyperlipidemia

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46OMIM, 32MalaCards
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MalaCards: Familial Combined Hyperlipidemia, also known as hyperlipidemia, familial combined, susceptibility to, is related to familial hyperlipidemia and familial hypertriglyceridemia. An important gene associated with Familial Combined Hyperlipidemia is USF1 (upstream transcription factor 1), and among its related pathways are Scavenging by Class B Receptors and CDP-diacylglycerol biosynthesis I. The compounds rosiglitazone and fenofibric acid have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and liver, and related mouse phenotypes are cardiovascular system and adipose tissue.

Description from OMIM:46 144250,602491

Aliases & Classifications for Familial Combined Hyperlipidemia

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8Disease Ontology, 9diseasecard, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases, Genetic diseases


Aliases & Descriptions:

familial combined hyperlipidemia 8 10
hyperlipidemia, familial combined, susceptibility to 9 22
hyperlipidemia, familial combined 46 60
combined hyperlipidemia, familial 9 46
mixed hyperlipidemia 8 44
hyperbetalipoproteinemia with prebetalipoproteinemia 8
familial multiple lipoprotein-type hyperlipidemia 8
hyperlipidemia familial combined 44
type iib hyperlipoproteinemia 8
hyperlipoproteinemia type iib 60
mixed hyperlipidaemia 8


External Ids:

Disease Ontology8 DOID:13809
ICD9CM27 272.2
NCIt39 C34821
OMIM46 144250
MeSH34 D006950
ICD1025 E78.2

Related Diseases for Familial Combined Hyperlipidemia

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17GeneCards, 18GeneDecks
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Diseases in the Familial Combined Hyperlipidemia family:

Hyperlipidemia, Combined, 2

Diseases related to Familial Combined Hyperlipidemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1familial hyperlipidemia31.9LSL, UCP1, APOA1, LIPE, LIPC, LPL
2familial hypertriglyceridemia30.9USF1, LPL, APOB, APOC3
3familial hypercholesterolemia30.8APOA1, APOA4, APOB, LPL, LIPC
4coronary artery disease30.7APOA1, APOA5, APOC3, APOA4, APOB, LPL
5obesity30.6APOA4, APOC3, APOA5, APOA1, UCP1, LSL
6atherosclerosis30.6LSL, MNDA, LIPE, LIPC, ATHS, USF1
7hypertension30.5LPL, APOB, APOA1
8type 2 diabetes mellitus30.5LIPE, LIPC, USF1, LPL, FABP2, APOB
9diabetes mellitus30.5FABP2, FADS1, APOB, APOC2, APOA4, APOC3
10pancreatitis30.3LPL, APOC2
11hyperlipoproteinemia type v30.1APOC2, LPL
12vascular disease30.1APOA1, APOA4, APOC2, APOB, LPL, LIPC
13fatty liver disease30.1LSL, APOA1, APOC3, APOB, FABP2, LPL
14hypertriglyceridemia30.1APOB, APOC2, APOA4, APOC3, APOA5, APOA1
15hyperlipidemia type 330.1APOA1, APOA5, APOB, LPL, LIPC
16hepatitis10.5
17acute pancreatitis10.2
18hyperlipoproteinemia type iii10.2
19histiocytosis10.2
20hyperapobetalipoproteinemia10.2
21otosclerosis10.1
22panhypopituitarism10.1
23hepatitis b10.1
24adult syndrome10.1
25hepatitis a10.1
26liver disease10.1
27retinitis10.1
28hypopituitarism10.1
29lipoprotein lipase deficiency10.0LPL
30growth hormone deficiency10.0LSL
31thromboembolism10.0APOA1
32hyperuricemia10.0FABP2, APOB
33hepatitis c10.0LPL
34acute myocardial infarction10.0APOB, APOA1
35abetalipoproteinemia10.0APOA1, APOB, LPL
36hyperalphalipoproteinemia10.0APOA1, APOC3, APOB, LIPC
37xanthomatosis10.0LPL, APOB
38norum disease10.0LPL, APOB, APOA1
39metabolic syndrome x10.0LSL, LPL
40hypobetalipoproteinemia10.0APOA1, APOB
41acromegaly10.0LSL
42glucose intolerance10.0LSL, APOB, LPL, LIPE
43nephrotic syndrome10.0APOA1, APOB, LPL
44lipodystrophy10.0LSL, APOC3, LIPE, LPL, APOB
45uremia10.0LIPC, LPL, APOC3, LSL
46polycystic ovary syndrome10.0LSL, APOA1, LIPC, LIPE
47hyperinsulinism10.0LPL, APOB, LSL
48hypoalphalipoproteinemia10.0APOA1, APOC3, APOB, LPL, LIPC
49familial lipoprotein lipase deficiency10.0LPL
50tangier disease10.0LPL, APOB, APOC3, APOA1

Graphical network of the top 20 diseases related to Familial Combined Hyperlipidemia:



Diseases related to familial combined hyperlipidemia

Clinical Features for Familial Combined Hyperlipidemia

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46OMIM
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Clinical features from OMIM:

144250,602491

Clinical synopsis from OMIM:

144250

Drugs & Therapeutics for Familial Combined Hyperlipidemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Familial Combined Hyperlipidemia

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Genetic Tests for Familial Combined Hyperlipidemia

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22GTR
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Genetic tests related to Familial Combined Hyperlipidemia:

id Genetic test Affiliating Genes
1 Hyperlipidemia, Familial Combined22

Anatomical Context for Familial Combined Hyperlipidemia

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32MalaCards
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MalaCards organs/tissues related to Familial Combined Hyperlipidemia:

32
Heart, Endothelial, Liver, Adipocyte, Skin, Lung, Monocytes, T cells

Animal Models for Familial Combined Hyperlipidemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Familial Combined Hyperlipidemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.1LIPE, LPL, APOB, APOA4, APOC3, APOA1
2MP:000537510.0C5AR2, PNPLA2, LIPE, LPL, FABP2, APOC3
3MP:00053709.8APOA1, APOB, FABP2, LPL, LIPE, PNPLA2
4MP:00053769.8APOC3, APOA1, APOA4, APOB, FADS1, FABP2

Publications for Familial Combined Hyperlipidemia

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50PubMed
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Articles related to Familial Combined Hyperlipidemia:

(show top 50)    (show all 272)
idTitleAuthorsYear
1
Unilateral retinal emboli in a patient with familial combined hyperlipidemia. (20408099)
2010
2
Genetic variants in adipose triglyceride lipase influence lipid levels in familial combined hyperlipidemia. (20832801)
2010
3
Serum adiponectin is decreased in patients with familial combined hyperlipidemia and normolipaemic relatives and is influenced by lipid-lowering treatment. (19632099)
2009
4
Adiponectin multimer distribution in patients with familial combined hyperlipidemia. (18762168)
2008
5
Plasma PAI-1 levels are independently related to fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, involvement of apolipoprotein E. (18262228)
2008
6
Insulin resistance and oxidative stress in familial combined hyperlipidemia. (18164710)
2008
7
Altered vascular responses to circulating angiotensin II in familial combined hyperlipidemia. (18799967)
2008
8
Tumor necrosis factor-alpha is a marker of familial combined hyperlipidemia, independently of metabolic syndrome. (18328361)
2008
9
Metabolic syndrome prevalence and characteristics in Greek adults with familial combined hyperlipidemia. (17161236)
2007
10
Vascular remodeling and prothrombotic markers in subjects affected by familial combined hyperlipidemia and/or metabolic syndrome in primary prevention for cardiovascular disease. (17922335)
2007
11
Evidence that non-lipid cardiovascular risk factors are associated with high prevalence of coronary artery disease in patients with heterozygous familial hypercholesterolemia or familial combined hyperlipidemia. (17188767)
2007
12
Pulse wave velocity in familial combined hyperlipidemia. (17324737)
2007
13
Nutrition, body weight and deterioration of familial combined hyperlipidemia. (17243549)
2006
14
Longitudinal differences in familial combined hyperlipidemia quantitative trait loci. (16709948)
2006
15
Role of insulin resistance in familial combined hyperlipidemia. (15731490)
2005
16
An omega-3 polyunsaturated fatty acid concentrate increases plasma high-density lipoprotein 2 cholesterol and paraoxonase levels in patients with familial combined hyperlipidemia. (14767865)
2004
17
Familial combined hyperlipidemia: controversial aspects of its diagnosis and pathogenesis. (15478042)
2004
18
Effects of atorvastatin on the clearance of triglyceride-rich lipoproteins in familial combined hyperlipidemia. (15579746)
2004
19
Radiological evidence of nonalcoholic fatty liver disease in familial combined hyperlipidemia. (15178501)
2004
20
An association of apolipoprotein B with pulse pressure in Chinese pedigrees with familial combined hyperlipidemia]. (15061989)
2004
21
Effects of atorvastatin on fasting plasma and marginated apolipoproteins B48 and B100 in large, triglyceride-rich lipoproteins in familial combined hyperlipidemia. (15472200)
2004
22
Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia. (14551155)
2004
23
TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study. (15136067)
2004
24
Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia. (12738753)
2003
25
Variants in the PPARgamma gene affect fatty acid and glycerol metabolism in familial combined hyperlipidemia. (14680975)
2003
26
Screening for familial combined hyperlipidemia in children using lipid phenotypes. (14718747)
2003
27
Apolipoprotein A-II: active or passive role in familial combined hyperlipidemia. (12805235)
2003
28
Gender differences in postprandial ketone bodies in normolipidemic subjects and in untreated patients with familial combined hyperlipidemia. (12933534)
2003
29
Lipoprotein distribution in the metabolic syndrome, type 2 diabetes mellitus, and familial combined hyperlipidemia. (12957324)
2003
30
Postprandial changes of apoB-100 and apoB-48 in TG rich lipoproteins in familial combined hyperlipidemia. (11861669)
2002
31
Increased intima-media thickness in familial combined hyperlipidemia associated with apolipoprotein B. (11834529)
2002
32
Newly identified apolipoprotein AV gene predisposes to high plasma triglycerides in familial combined hyperlipidemia. (12194944)
2002
33
Serum C3 but not plasma acylation-stimulating protein is elevated in Finnish patients with familial combined hyperlipidemia. (11348883)
2001
34
Excess coronary heart disease in Familial Combined Hyperlipidemia, in relation to genetic factors and central obesity. (11472750)
2001
35
A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia. (11574425)
2001
36
Relationship of insulin sensitivity and ApoB levels to intra-abdominal fat in subjects with familial combined hyperlipidemia. (11304474)
2001
37
Mutations of the human hepatic lipase gene in patients with combined hypertriglyceridemia/hyperalphalipoproteinemia and in patients with familial combined hyperlipidemia. (10606208)
1999
38
Coronary flow reserve in young men with familial combined hyperlipidemia. (10190876)
1999
39
Evidence against linkage of familial combined hyperlipidemia to the apolipoprotein AI-CIII-AIV gene complex. (9484986)
1998
40
No evidence of linkage between familial combined hyperlipidemia and genes encoding lipolytic enzymes in Finnish families. (9157946)
1997
41
Hypertriglyceridemia and plasma insulin in combined familial hyperlipidemia]. (9547191)
1997
42
The redox status of coenzyme Q10 in total LDL as an indicator of in vivo oxidative modification. Studies on subjects with familial combined hyperlipidemia. (9012647)
1997
43
In vitro lipolysis of human VLDL: effect of different VLDL compositions in normolipidemia, familial combined hyperlipidemia and familial hypertriglyceridemia. (8678926)
1996
44
Inherited susceptibility determines the distribution of dense low-density lipoprotein subfraction profiles in familial combined hyperlipidemia. (8644746)
1996
45
A frequently occurring mutation in the lipoprotein lipase gene (Asn291Ser) contributes to the expression of familial combined hyperlipidemia. (8541837)
1995
46
Pravastatin effectively lowers LDL cholesterol in familial combined hyperlipidemia without changing LDL subclass pattern. (7918306)
1994
47
Plasma triglyceride and LDL heterogeneity in familial combined hyperlipidemia. (8443147)
1993
48
Lipoprotein lipase modulates net secretory output of apolipoprotein B in vitro. A possible pathophysiologic explanation for familial combined hyperlipidemia. (1918380)
1991
49
Hyperapobetalipoproteinemia in a kindred with familial combined hyperlipidemia and familial hypercholesterolemia. (3593067)
1987
50
Familial combined hyperlipidemia and otosclerosis--the occurrence in a large kindred. (3976713)
1985

Genetic Variations for Familial Combined Hyperlipidemia

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Expression for genes affiliated with Familial Combined Hyperlipidemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Combined Hyperlipidemia

Search GEO for disease gene expression data for Familial Combined Hyperlipidemia.

Pathways for genes affiliated with Familial Combined Hyperlipidemia

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology, 49PharmGKB
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Compounds for genes affiliated with Familial Combined Hyperlipidemia

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Familial Combined Hyperlipidemia according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1rosiglitazone44 49 28 11 2414.7LIPE, LSL, UCP1
2fenofibric acid44 2811.7APOB, APOC3, APOA1, LPL
3palmitate4410.7UCP1, FABP2
4xbai4410.7APOC3, APOA4, APOB, LPL
5retinyl palmitate44 2411.7APOA1, APOB, LPL, APOA4
6trioleoylglycerol4410.7APOC2, LPL, APOA1, LIPC
7acipimox44 2811.6LSL, APOA1, APOB, LIPE
8probucol44 1111.6LIPC, LPL, APOB, APOA1
9orlistat44 59 1112.6LSL, APOB, LPL, LIPC
10stearic acid44 11 2412.6FABP2, PNPLA2, LIPE, LPL, LIPC
11gemfibrozil44 28 1112.6LIPC, APOB, LPL, APOA1, APOC3, APOC2
12palmitic acid28 11 2412.6PNPLA2, LIPC, LPL, LIPE, FABP2
13oleic acid44 28 11 2413.6LIPE, APOA4, FABP2, LPL, LIPC, APOB
14bezafibrate44 28 1112.6APOB, APOC3, LIPC, UCP1, APOA1, LPL
15myristic acid44 11 2412.6LIPC, FABP2, LIPE, LPL, PNPLA2
16mspi4410.6APOB, APOA1, APOC3, APOA4
17carnitine4410.6LIPE, LPL, APOB, APOA1, UCP1
18cholesterol ester4410.6APOB, LPL, LIPC, APOA4, APOC3, APOA1
19lovastatin44 49 59 28 1114.6APOC3, APOB, LPL, LIPC, APOA1
20fenofibrate44 49 1112.6FABP2, LIPC, APOB, APOC3, APOA5, APOA1
21taurocholate4410.6APOC3, LPL, APOB, APOA1
22phosphatidylcholine4410.6LIPC, APOB, APOA1, APOA4, LPL, LIPE
23intralipid4410.5APOC3, APOA4, APOB, LPL, LIPC, LSL
24niacin44 1111.5APOB, LIPE, LPL, APOA1
25atorvastatin44 49 28 11 2414.5LPL, APOB, APOA1, APOC3, LIPC
26thyroxine44 2411.5LIPC, LPL, APOA1, UCP1, LSL, APOB
27homocysteine44 2411.5APOC2, LSL, APOA1, APOC3, APOB
28linoleic acid44 28 2412.5UCP1, FADS1, FABP2, LPL, LSL
29vitamin a44 11 2412.5APOC3, LIPC, LPL, APOB, APOC2, APOA4
30p0024410.5APOA4, LIPC, APOC3, UCP1, LSL
31heparin44 28 11 2413.5APOA4, LSL, APOA5, APOC3, LPL, APOC2
32stavudine44 1111.4APOA1, LPL, UCP1
33carbohydrates4410.4LPL, FABP2, APOC3, LIPC, LSL
34sterol4410.4LIPE, LIPC, USF1, APOB, APOA1
35testosterone44 59 11 2413.4APOC3, LIPE, LIPC, LPL, APOA1, UCP1
36fibrinogen4410.4APOC3, LSL, LIPC, APOB, APOA4, APOA1
37creatinine4410.4FABP2, APOC2, APOA4, APOA1, APOB, LSL
38glycerol44 11 2412.3LIPE, LSL, LIPC, PNPLA2, LPL
39ciprofibrate44 2811.3APOB, APOA1, LPL
40phospholipid4410.3LIPE, LIPC, LPL, FABP2, FADS1, APOC3
41metformin44 49 1112.3LPL, APOB, APOA1, LSL
42triacylglycerol4410.3APOA4, PNPLA2, LIPE, LIPC, LPL, FABP2
43estrogen4410.2LIPC, APOA1, LSL, APOC3, LIPE, APOB
44glucose4410.2APOA5, APOA1, UCP1, LSL, LIPE, LIPC
45fatty acid4410.2PNPLA2, LIPE, LIPC, LPL, FABP2, FADS1
46arachidonic acid44 28 11 2413.1FABP2, PNPLA2, LIPE, LIPC, LPL, FADS1
47acetyl-coa44 2411.1LPL, FABP2, LIPC, USF1, LIPE
48cholesterol44 28 11 2413.1LSL, UCP1, APOA1, APOA5, APOC3, LIPE
49lipid4410.0APOA4, PNPLA2, MNDA, LIPE, LIPC, LSL
50pyruvate449.9USF1, LIPE, UCP1, FABP2, APOC3

GO Terms for genes affiliated with Familial Combined Hyperlipidemia

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16Gene Ontology
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Cellular components related to Familial Combined Hyperlipidemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:03436310.5APOB, APOC2, APOC3
2high-density lipoprotein particleGO:03436410.4APOA1, APOA5, APOA4, LIPC
3spherical high-density lipoprotein particleGO:03436610.4APOA1, APOC3, APOC2
4chylomicronGO:04262710.4APOA5, APOC3, APOA4, APOC2, APOB, LPL
5endocytic vesicle lumenGO:07168210.4APOB, APOA1
6very-low-density lipoprotein particleGO:03436110.4LPL, APOA1, APOA5, APOC3, APOA4, APOC2
7low-density lipoprotein particleGO:03436210.2APOA5, APOC2, APOB
8early endosomeGO:00576910.2APOA1, APOC3, APOA4, APOC2, APOB
9extracellular spaceGO:00561510.1APOA1, APOA5, APOC3, APOA4, APOC2, APOB
10extracellular regionGO:0055769.8APOA1, APOA5, APOC3, APOA4, APOC2, APOB

Biological processes related to Familial Combined Hyperlipidemia according to GeneCards/GeneDecks:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of very-low-density lipoprotein particle remodelingGO:01090210.7APOC2, APOA5
2negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.7APOC3, APOA1
3chylomicron remodelingGO:03437110.7APOA4, APOC2, LPL
4triglyceride-rich lipoprotein particle remodelingGO:03437010.7APOC2, APOA5
5negative regulation of lipid metabolic processGO:04583310.7APOC3, APOC2
6chylomicron remnant clearanceGO:03438210.7LIPC, APOC2, APOC3
7positive regulation of fatty acid biosynthetic processGO:04572310.7APOC2, APOA4, APOA5
8lipoprotein transportGO:04295310.7APOB, APOC2, APOC3
9triglyceride metabolic processGO:00664110.7APOA5, APOC3, LPL
10regulation of Cdc42 protein signal transductionGO:03248910.7APOA1, APOC3
11positive regulation of lipoprotein lipase activityGO:05100610.7APOA5, APOA4, APOC2
12positive regulation of triglyceride catabolic processGO:01089810.7PNPLA2, APOC2, APOA4, APOA5
13very-low-density lipoprotein particle remodelingGO:03437210.7APOA4, APOC2, LPL, LIPC
14regulation of intestinal cholesterol absorptionGO:03030010.7APOA1, APOA4
15negative regulation of very-low-density lipoprotein particle clearanceGO:01091610.7APOC3, APOC2
16phospholipid effluxGO:03370010.7APOA1, APOC3, APOA4, APOC2
17triglyceride mobilizationGO:00664210.6APOC3, APOB
18lipoprotein biosynthetic processGO:04215810.6APOA1, APOB
19high-density lipoprotein particle remodelingGO:03437510.6APOA1, APOC3, APOA4, LIPC
20cholesterol effluxGO:03334410.6APOA1, APOC3, APOA4, APOC2, APOB
21reverse cholesterol transportGO:04369110.6APOA1, APOC3, APOA4, APOC2, LIPC
22negative regulation of receptor-mediated endocytosisGO:04826110.6APOC3, APOC2
23retinoid metabolic processGO:00152310.6APOA1, APOC3, APOA4, APOC2, APOB, LPL
24triglyceride homeostasisGO:07032810.6APOA1, APOA5, APOC3, APOC2, LPL, LIPC
25high-density lipoprotein particle clearanceGO:03438410.6APOA1, APOC2
26cholesterol metabolic processGO:00820310.6APOA1, APOC3, APOA4, APOB, LIPC, LIPE
27phototransduction, visible lightGO:00760310.6APOA1, APOC3, APOA4, APOC2, APOB, LPL
28positive regulation of cholesterol esterificationGO:01087310.6APOA4, APOA1
29positive regulation of cholesterol storageGO:01088610.6LPL, APOB
30triglyceride catabolic processGO:01943310.6PNPLA2, APOA5, APOC3, APOB, LPL, LIPC
31lipoprotein metabolic processGO:04215710.6APOA1, APOA5, APOC3, APOA4, APOC2, APOB
32very-low-density lipoprotein particle assemblyGO:03437910.5APOC3, APOB
33cholesterol homeostasisGO:04263210.5APOA1, APOA5, APOC3, APOA4, APOC2, APOB
34unsaturated fatty acid biosynthetic processGO:00663610.4FADS1, FADS3
35low-density lipoprotein particle remodelingGO:03437410.4LIPC, APOB
36lipid homeostasisGO:05508810.4USF1, APOA4
37response to drugGO:04249310.3APOA1, APOC3, APOC2, LPL
38cholesterol transportGO:03030110.3APOB, APOA1
39small molecule metabolic processGO:04428110.3UCP1, APOA1, APOA5, APOC3, APOA4, APOC2
40positive regulation of macrophage derived foam cell differentiationGO:01074410.1LPL, APOB

Molecular functions related to Familial Combined Hyperlipidemia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particle receptor bindingGO:07065310.6APOA1, APOC3
2lipase inhibitor activityGO:05510210.6APOC2, APOC3, APOA1
3cholesterol transporter activityGO:01712710.6APOA1, APOA4, APOB
4lipoprotein lipase activator activityGO:06023010.6APOA5, APOC2
5triglyceride lipase activityGO:00480610.6PNPLA2, LIPE, LIPC, LPL
6phosphatidylcholine-sterol O-acyltransferase activator activityGO:06022810.5APOA1, APOA4
7phospholipase activityGO:00462010.5LIPC, LPL
8heparin bindingGO:00820110.5LIPC, LPL, APOB, APOA5
9phosphatidylcholine bindingGO:03121010.4APOA4, APOA5
10enzyme bindingGO:01989910.4APOA1, APOA5, APOB, USF1
11low-density lipoprotein particle receptor bindingGO:05075010.4APOA5, APOB
12lipid bindingGO:00828910.3APOC2, APOA4, APOA5
13phospholipid bindingGO:00554310.2APOB, APOC3, APOA5, APOA1
14apolipoprotein bindingGO:03418510.1LPL, LIPC

Products for genes affiliated with Familial Combined Hyperlipidemia

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27ICD9CM
28IUPHAR
29KEGG
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40NDF-RT
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