MCID: FML020
MIFTS: 63

Familial Combined Hyperlipidemia malady

Metabolic diseases, Genetic diseases categories

Summaries for Familial Combined Hyperlipidemia

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46OMIM, 32MalaCards
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MalaCards: Familial Combined Hyperlipidemia, also known as hyperlipidemia, familial combined, susceptibility to, is related to familial hyperlipidemia and familial hypertriglyceridemia. An important gene associated with Familial Combined Hyperlipidemia is USF1 (upstream transcription factor 1), and among its related pathways are Scavenging by Class B Receptors and CDP-diacylglycerol biosynthesis I. The compounds rosiglitazone and fenofibric acid have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and liver, and related mouse phenotypes are cardiovascular system and adipose tissue.

Description from OMIM:46 144250,602491

Aliases & Classifications for Familial Combined Hyperlipidemia

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8Disease Ontology, 9diseasecard, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases, Genetic diseases


Aliases & Descriptions:

familial combined hyperlipidemia 8 10
hyperlipidemia, familial combined, susceptibility to 9 22
hyperlipidemia, familial combined 46 60
combined hyperlipidemia, familial 9 46
mixed hyperlipidemia 8 44
hyperbetalipoproteinemia with prebetalipoproteinemia 8
familial multiple lipoprotein-type hyperlipidemia 8
hyperlipidemia familial combined 44
type iib hyperlipoproteinemia 8
hyperlipoproteinemia type iib 60
mixed hyperlipidaemia 8


External Ids:

Disease Ontology8 DOID:13809
ICD9CM27 272.2
NCIt39 C34821
OMIM46 144250
MeSH34 D006950
ICD1025 E78.2

Related Diseases for Familial Combined Hyperlipidemia

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17GeneCards, 18GeneDecks
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Diseases in the Familial Combined Hyperlipidemia family:

Hyperlipidemia, Combined, 2

Diseases related to Familial Combined Hyperlipidemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1familial hyperlipidemia31.9LSL, UCP1, APOA1, LIPE, LIPC, LPL
2familial hypertriglyceridemia30.9USF1, LPL, APOB, APOC3
3familial hypercholesterolemia30.8APOA1, APOA4, APOB, LPL, LIPC
4coronary artery disease30.7APOA1, APOA5, APOC3, APOA4, APOB, LPL
5obesity30.6APOA4, APOC3, APOA5, APOA1, UCP1, LSL
6atherosclerosis30.6LSL, MNDA, LIPE, LIPC, ATHS, USF1
7hypertension30.5LPL, APOB, APOA1
8type 2 diabetes mellitus30.5LIPE, LIPC, USF1, LPL, FABP2, APOB
9diabetes mellitus30.5FABP2, FADS1, APOB, APOC2, APOA4, APOC3
10pancreatitis30.3LPL, APOC2
11hyperlipoproteinemia type v30.1APOC2, LPL
12vascular disease30.1APOA1, APOA4, APOC2, APOB, LPL, LIPC
13fatty liver disease30.1LSL, APOA1, APOC3, APOB, FABP2, LPL
14hypertriglyceridemia30.1APOB, APOC2, APOA4, APOC3, APOA5, APOA1
15hyperlipidemia type 330.1APOA1, APOA5, APOB, LPL, LIPC
16hepatitis10.5
17acute pancreatitis10.2
18hyperlipoproteinemia type iii10.2
19histiocytosis10.2
20hyperapobetalipoproteinemia10.2
21otosclerosis10.1
22panhypopituitarism10.1
23hepatitis b10.1
24adult syndrome10.1
25hepatitis a10.1
26liver disease10.1
27retinitis10.1
28hypopituitarism10.1
29lipoprotein lipase deficiency10.0LPL
30growth hormone deficiency10.0LSL
31thromboembolism10.0APOA1
32hyperuricemia10.0FABP2, APOB
33hepatitis c10.0LPL
34acute myocardial infarction10.0APOB, APOA1
35abetalipoproteinemia10.0APOA1, APOB, LPL
36hyperalphalipoproteinemia10.0APOA1, APOC3, APOB, LIPC
37xanthomatosis10.0LPL, APOB
38norum disease10.0LPL, APOB, APOA1
39metabolic syndrome x10.0LSL, LPL
40hypobetalipoproteinemia10.0APOA1, APOB
41acromegaly10.0LSL
42glucose intolerance10.0LSL, APOB, LPL, LIPE
43nephrotic syndrome10.0APOA1, APOB, LPL
44lipodystrophy10.0LSL, APOC3, LIPE, LPL, APOB
45uremia10.0LIPC, LPL, APOC3, LSL
46polycystic ovary syndrome10.0LSL, APOA1, LIPC, LIPE
47hyperinsulinism10.0LPL, APOB, LSL
48hypoalphalipoproteinemia10.0APOA1, APOC3, APOB, LPL, LIPC
49familial lipoprotein lipase deficiency10.0LPL
50tangier disease10.0LPL, APOB, APOC3, APOA1

Graphical network of the top 20 diseases related to Familial Combined Hyperlipidemia:



Diseases related to familial combined hyperlipidemia

Clinical Features for Familial Combined Hyperlipidemia

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46OMIM
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Clinical features from OMIM:

144250,602491

Clinical synopsis from OMIM:

144250

Drugs & Therapeutics for Familial Combined Hyperlipidemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Familial Combined Hyperlipidemia

Search CenterWatch for Familial Combined Hyperlipidemia

Genetic Tests for Familial Combined Hyperlipidemia

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22GTR
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Genetic tests related to Familial Combined Hyperlipidemia:

id Genetic test Affiliating Genes
1 Hyperlipidemia, Familial Combined22

Anatomical Context for Familial Combined Hyperlipidemia

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32MalaCards
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MalaCards organs/tissues related to Familial Combined Hyperlipidemia:

32
Heart, Endothelial, Liver, Adipocyte, Lung, Skin, Monocytes, T cells

Animal Models for Familial Combined Hyperlipidemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Familial Combined Hyperlipidemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.1APOA1, APOC3, APOA4, APOB, LPL, LIPE
2MP:000537510.0UCP1, APOC3, FABP2, LPL, LIPE, PNPLA2
3MP:00053709.8APOA1, APOB, FABP2, LPL, LIPE, PNPLA2
4MP:00053769.8C5AR2, UCP1, APOA1, APOA5, APOC3, APOA4

Publications for Familial Combined Hyperlipidemia

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50PubMed
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Articles related to Familial Combined Hyperlipidemia:

(show top 50)    (show all 272)
idTitleAuthorsYear
1
Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia. (23333725)
2013
2
Pathway analysis detect potential mechanism for familial combined hyperlipidemia. (23877856)
2013
3
Association of RXR-Gamma Gene Variants with Familial Combined Hyperlipidemia: Genotype and Haplotype Analysis. (24222859)
2013
4
CDKN2B expression in adipose tissue of familial combined hyperlipidemia patients. (24103848)
2013
5
Apolipoprotein E gene mutations in subjects with mixed hyperlipidemia and a clinical diagnosis of familial combined hyperlipidemia. (22481068)
2012
6
Potential role of upstream stimulatory factor 1 gene variant in familial combined hyperlipidemia and related disorders. (22460558)
2012
7
S323I polymorphism of the C5L2 gene was not identified in a Chinese population with familial combined hyperlipidemia or with type 2 diabetes. (22194190)
2011
8
New technologies for delineating and characterizing the lipid exome: prospects for understanding familial combined hyperlipidemia. (19023136)
2009
9
Familial hypercholesterolemia and lipoprotein(a) hyperlipidemia as independent and combined cardiovascular risk factors. (20129380)
2009
10
Small dense LDL-cholesterol determined by a simple precipitation assay for screening familial combined hyperlipidemia. (19201411)
2009
11
Endothelial haemostatic markers in members of families with familial combined hyperlipidemia. (18417194)
2009
12
Relationship between familial combined hyperlipidemia and insulin resistance. (19069677)
2008
13
Frequent detection of familial hypercholesterolemia mutations in familial combined hyperlipidemia. (19007591)
2008
14
Carotid atherosclerosis in familial combined hyperlipidemia associated with the APOB/APOA-I ratio. (17698072)
2008
15
Associations of apolipoprotein B with pulse pressure and glucose in Chinese families with familial combined hyperlipidemia. (16797745)
2007
16
High plasma level of remnant-like particles cholesterol in familial combined hyperlipidemia. (17227806)
2007
17
Decreased adiponectin levels in familial combined hyperlipidemia patients contribute to the atherogenic lipid profile. (16106049)
2005
18
Tumor necrosis factor alpha (TNFalpha) and its soluble receptor p75 (sTNF-R p75) in familial combined hyperlipidemia (FCHL). (16054550)
2005
19
Genome scan for quantitative trait loci influencing HDL levels: evidence for multilocus inheritance in familial combined hyperlipidemia. (15959807)
2005
20
Circulating oxidized low-density lipoprotein and its association with carotid intima-media thickness in asymptomatic members of familial combined hyperlipidemia families. (15205217)
2004
21
Increased circulating malondialdehyde-modified LDL in the patients with familial combined hyperlipidemia and its relation with the hepatic lipase activity. (14709374)
2004
22
Contribution of chromosome 1q21-q23 to familial combined hyperlipidemia in Mexican families. (15469419)
2004
23
Differential gene expression of blood-derived cell lines in familial combined hyperlipidemia. (15388524)
2004
24
Determinants of low HDL levels in familial combined hyperlipidemia. (12777471)
2003
25
Postprandial triglyceride levels in familial combined hyperlipidemia. The role of apolipoprotein E and lipoprotein lipase polymorphisms. (12915220)
2003
26
C3, hormone-sensitive lipase, and peroxisome proliferator-activated receptor gamma expression in adipose tissue of familial combined hyperlipidemia patients. (11979403)
2002
27
Lack of agreement between the plasma lipid-based criteria and apoprotein B for the diagnosis of familial combined hyperlipidemia in members of familial combined hyperlipidemia kindreds. (11833052)
2002
28
Susceptibility of LDL to oxidation in vitro and antioxidant capacity in familial combined hyperlipidemia: comparison of patients with different lipid phenotypes. (12014434)
2002
29
Carotid intima-media thickness in familial combined hyperlipidemia and LDL size. (11988582)
2002
30
Familial combined hyperlipidemia plasma stimulates protein secretion by HepG2 cells: identification of fibronectin in the differential secretion proteome. (12401883)
2002
31
The V73M mutation in the hepatic lipase gene is associated with elevated cholesterol levels in four Dutch pedigrees with familial combined hyperlipidemia. (10924721)
2000
32
Replication of linkage of familial combined hyperlipidemia to chromosome 1q with additional heterogeneous effect of apolipoprotein A-I/C-III/A-IV locus. The NHLBI Family Heart Study. (11031215)
2000
33
Support for linkage of familial combined hyperlipidemia to chromosome 1q21-q23 in Chinese and German families. (10733233)
2000
34
Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic patients. (10634813)
2000
35
Association of plasma lipids and apolipoproteins with the insulin response element in the apoC-III promoter region in familial combined hyperlipidemia. (10357835)
1999
36
A common genetic mechanism determines plasma apolipoprotein B levels and dense LDL subfraction distribution in familial combined hyperlipidemia. (9683593)
1998
37
Evidence against alterations in Lecithin:cholesterol acyltransferase (LCAT) activity in familial combined hyperlipidemia. (9690923)
1998
38
Nonobese patients with familial combined hyperlipidemia are insulin resistant compared with their nonaffected relatives. (9261281)
1997
39
Adipose tissue lipoprotein lipase and hormone-sensitive lipase. Contrasting findings in familial combined hyperlipidemia and insulin resistance syndrome. (9351402)
1997
40
Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes. (9062353)
1997
41
The effect of micronized fenofibrate on lipid parameters and fibrinogen in heterozygous familial hypercholesterolemia and familial combined hyperlipidemia]. (8925538)
1996
42
Treatment of severe, resistant familial combined hyperlipidemia with a bezafibrate-lovastatin combination. (8519043)
1993
43
Effects of fish oil concentrate on lipoproteins and apolipoproteins in familial combined hyperlipidemia. (8471818)
1993
44
Impaired fatty acid metabolism in familial combined hyperlipidemia. A mechanism associating hepatic apolipoprotein B overproduction and insulin resistance. (8100834)
1993
45
Stable isotopes show a direct relation between VLDL apoB overproduction and serum triglyceride levels and indicate a metabolically and biochemically coherent basis for familial combined hyperlipidemia. (8318511)
1993
46
Familial combined hyperlipidemia and abnormal lipoprotein lipase. (1390589)
1992
47
Bimodality of plasma apolipoprotein B levels in familial combined hyperlipidemia. (1575822)
1992
48
Familial combined hyperlipidemia. Part II. Clinical picture. (2946184)
1986
49
Low density lipoprotein metabolism in familial combined hyperlipidemia. Mechanism of the multiple lipoprotein phenotypic expression. (6508636)
1984
50
Integrated regulation of very low density lipoprotein triglyceride and apolipoprotein-B kinetics in man: normolipemic subjects, familial hypertriglyceridemia and familial combined hyperlipidemia. (7266376)
1981

Genetic Variations for Familial Combined Hyperlipidemia

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Expression for genes affiliated with Familial Combined Hyperlipidemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Combined Hyperlipidemia

Search GEO for disease gene expression data for Familial Combined Hyperlipidemia.

Pathways for genes affiliated with Familial Combined Hyperlipidemia

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology, 49PharmGKB
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Compounds for genes affiliated with Familial Combined Hyperlipidemia

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Familial Combined Hyperlipidemia according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1rosiglitazone44 49 28 11 2414.7LIPE, LSL, UCP1
2fenofibric acid44 2811.7APOB, APOC3, APOA1, LPL
3palmitate4410.7UCP1, FABP2
4xbai4410.7APOC3, APOA4, APOB, LPL
5retinyl palmitate44 2411.7APOA1, APOB, LPL, APOA4
6trioleoylglycerol4410.7APOC2, LPL, APOA1, LIPC
7acipimox44 2811.6LSL, APOA1, APOB, LIPE
8probucol44 1111.6LIPC, LPL, APOB, APOA1
9orlistat44 59 1112.6LSL, APOB, LPL, LIPC
10stearic acid44 11 2412.6FABP2, PNPLA2, LIPE, LPL, LIPC
11gemfibrozil44 28 1112.6LIPC, APOB, LPL, APOA1, APOC3, APOC2
12palmitic acid28 11 2412.6PNPLA2, LIPC, LPL, LIPE, FABP2
13oleic acid44 28 11 2413.6LIPE, APOA4, FABP2, LPL, LIPC, APOB
14bezafibrate44 28 1112.6APOB, APOC3, LIPC, UCP1, APOA1, LPL
15myristic acid44 11 2412.6LIPC, FABP2, LIPE, LPL, PNPLA2
16mspi4410.6APOB, APOA1, APOC3, APOA4
17carnitine4410.6LIPE, LPL, APOB, APOA1, UCP1
18cholesterol ester4410.6APOB, LPL, LIPC, APOA4, APOC3, APOA1
19lovastatin44 49 59 28 1114.6APOC3, APOB, LPL, LIPC, APOA1
20fenofibrate44 49 1112.6FABP2, LIPC, APOB, APOC3, APOA5, APOA1
21taurocholate4410.6APOC3, LPL, APOB, APOA1
22phosphatidylcholine4410.6LIPC, APOB, APOA1, APOA4, LPL, LIPE
23intralipid4410.5APOC3, APOA4, APOB, LPL, LIPC, LSL
24niacin44 1111.5APOB, LIPE, LPL, APOA1
25atorvastatin44 49 28 11 2414.5LPL, APOB, APOA1, APOC3, LIPC
26thyroxine44 2411.5LIPC, LPL, APOA1, UCP1, LSL, APOB
27homocysteine44 2411.5APOC2, LSL, APOA1, APOC3, APOB
28linoleic acid44 28 2412.5UCP1, FADS1, FABP2, LPL, LSL
29vitamin a44 11 2412.5APOC3, LIPC, LPL, APOB, APOC2, APOA4
30p0024410.5APOA4, LIPC, APOC3, UCP1, LSL
31heparin44 28 11 2413.5APOA4, LSL, APOA5, APOC3, LPL, APOC2
32stavudine44 1111.4APOA1, LPL, UCP1
33carbohydrates4410.4LPL, FABP2, APOC3, LIPC, LSL
34sterol4410.4LIPE, LIPC, USF1, APOB, APOA1
35testosterone44 59 11 2413.4APOC3, LIPE, LIPC, LPL, APOA1, UCP1
36fibrinogen4410.4APOC3, LSL, LIPC, APOB, APOA4, APOA1
37creatinine4410.4FABP2, APOC2, APOA4, APOA1, APOB, LSL
38glycerol44 11 2412.3LIPE, LSL, LIPC, PNPLA2, LPL
39ciprofibrate44 2811.3APOB, APOA1, LPL
40phospholipid4410.3LIPE, LIPC, LPL, FABP2, FADS1, APOC3
41metformin44 49 1112.3LPL, APOB, APOA1, LSL
42triacylglycerol4410.3APOA4, PNPLA2, LIPE, LIPC, LPL, FABP2
43estrogen4410.2LIPC, APOA1, LSL, APOC3, LIPE, APOB
44glucose4410.2APOA5, APOA1, UCP1, LSL, LIPE, LIPC
45fatty acid4410.2PNPLA2, LIPE, LIPC, LPL, FABP2, FADS1
46arachidonic acid44 28 11 2413.1FABP2, PNPLA2, LIPE, LIPC, LPL, FADS1
47acetyl-coa44 2411.1LPL, FABP2, LIPC, USF1, LIPE
48cholesterol44 28 11 2413.1LSL, UCP1, APOA1, APOA5, APOC3, LIPE
49lipid4410.0APOA4, PNPLA2, MNDA, LIPE, LIPC, LSL
50pyruvate449.9USF1, LIPE, UCP1, FABP2, APOC3

GO Terms for genes affiliated with Familial Combined Hyperlipidemia

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16Gene Ontology
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Cellular components related to Familial Combined Hyperlipidemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate-density lipoprotein particleGO:03436310.5APOB, APOC2, APOC3
2high-density lipoprotein particleGO:03436410.4APOA1, APOA5, APOA4, LIPC
3spherical high-density lipoprotein particleGO:03436610.4APOA1, APOC3, APOC2
4chylomicronGO:04262710.4APOA5, APOC3, APOA4, APOC2, APOB, LPL
5endocytic vesicle lumenGO:07168210.4APOB, APOA1
6very-low-density lipoprotein particleGO:03436110.4LPL, APOA1, APOA5, APOC3, APOA4, APOC2
7low-density lipoprotein particleGO:03436210.2APOA5, APOC2, APOB
8early endosomeGO:00576910.2APOA1, APOC3, APOA4, APOC2, APOB
9extracellular spaceGO:00561510.1APOA1, APOA5, APOC3, APOA4, APOC2, APOB
10extracellular regionGO:0055769.8APOA1, APOA5, APOC3, APOA4, APOC2, APOB

Biological processes related to Familial Combined Hyperlipidemia according to GeneCards/GeneDecks:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of very-low-density lipoprotein particle remodelingGO:01090210.7APOC2, APOA5
2negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.7APOC3, APOA1
3chylomicron remodelingGO:03437110.7APOA4, APOC2, LPL
4triglyceride-rich lipoprotein particle remodelingGO:03437010.7APOC2, APOA5
5negative regulation of lipid metabolic processGO:04583310.7APOC3, APOC2
6chylomicron remnant clearanceGO:03438210.7LIPC, APOC2, APOC3
7positive regulation of fatty acid biosynthetic processGO:04572310.7APOC2, APOA4, APOA5
8lipoprotein transportGO:04295310.7APOB, APOC2, APOC3
9triglyceride metabolic processGO:00664110.7APOA5, APOC3, LPL
10regulation of Cdc42 protein signal transductionGO:03248910.7APOA1, APOC3
11positive regulation of lipoprotein lipase activityGO:05100610.7APOA5, APOA4, APOC2
12positive regulation of triglyceride catabolic processGO:01089810.7PNPLA2, APOC2, APOA4, APOA5
13very-low-density lipoprotein particle remodelingGO:03437210.7APOA4, APOC2, LPL, LIPC
14regulation of intestinal cholesterol absorptionGO:03030010.7APOA1, APOA4
15negative regulation of very-low-density lipoprotein particle clearanceGO:01091610.7APOC3, APOC2
16phospholipid effluxGO:03370010.7APOA1, APOC3, APOA4, APOC2
17triglyceride mobilizationGO:00664210.6APOC3, APOB
18lipoprotein biosynthetic processGO:04215810.6APOA1, APOB
19high-density lipoprotein particle remodelingGO:03437510.6APOA1, APOC3, APOA4, LIPC
20cholesterol effluxGO:03334410.6APOA1, APOC3, APOA4, APOC2, APOB
21reverse cholesterol transportGO:04369110.6APOA1, APOC3, APOA4, APOC2, LIPC
22negative regulation of receptor-mediated endocytosisGO:04826110.6APOC3, APOC2
23retinoid metabolic processGO:00152310.6APOA1, APOC3, APOA4, APOC2, APOB, LPL
24triglyceride homeostasisGO:07032810.6APOA1, APOA5, APOC3, APOC2, LPL, LIPC
25high-density lipoprotein particle clearanceGO:03438410.6APOA1, APOC2
26cholesterol metabolic processGO:00820310.6APOA1, APOC3, APOA4, APOB, LIPC, LIPE
27phototransduction, visible lightGO:00760310.6APOA1, APOC3, APOA4, APOC2, APOB, LPL
28positive regulation of cholesterol esterificationGO:01087310.6APOA4, APOA1
29positive regulation of cholesterol storageGO:01088610.6LPL, APOB
30triglyceride catabolic processGO:01943310.6PNPLA2, APOA5, APOC3, APOB, LPL, LIPC
31lipoprotein metabolic processGO:04215710.6APOA1, APOA5, APOC3, APOA4, APOC2, APOB
32very-low-density lipoprotein particle assemblyGO:03437910.5APOC3, APOB
33cholesterol homeostasisGO:04263210.5APOA1, APOA5, APOC3, APOA4, APOC2, APOB
34unsaturated fatty acid biosynthetic processGO:00663610.4FADS1, FADS3
35low-density lipoprotein particle remodelingGO:03437410.4LIPC, APOB
36lipid homeostasisGO:05508810.4USF1, APOA4
37response to drugGO:04249310.3APOA1, APOC3, APOC2, LPL
38cholesterol transportGO:03030110.3APOB, APOA1
39small molecule metabolic processGO:04428110.3UCP1, APOA1, APOA5, APOC3, APOA4, APOC2
40positive regulation of macrophage derived foam cell differentiationGO:01074410.1LPL, APOB

Molecular functions related to Familial Combined Hyperlipidemia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particle receptor bindingGO:07065310.6APOA1, APOC3
2lipase inhibitor activityGO:05510210.6APOC2, APOC3, APOA1
3cholesterol transporter activityGO:01712710.6APOA1, APOA4, APOB
4lipoprotein lipase activator activityGO:06023010.6APOA5, APOC2
5triglyceride lipase activityGO:00480610.6PNPLA2, LIPE, LIPC, LPL
6phosphatidylcholine-sterol O-acyltransferase activator activityGO:06022810.5APOA1, APOA4
7phospholipase activityGO:00462010.5LIPC, LPL
8heparin bindingGO:00820110.5LIPC, LPL, APOB, APOA5
9phosphatidylcholine bindingGO:03121010.4APOA4, APOA5
10enzyme bindingGO:01989910.4APOA1, APOA5, APOB, USF1
11low-density lipoprotein particle receptor bindingGO:05075010.4APOA5, APOB
12lipid bindingGO:00828910.3APOC2, APOA4, APOA5
13phospholipid bindingGO:00554310.2APOB, APOC3, APOA5, APOA1
14apolipoprotein bindingGO:03418510.1LPL, LIPC

Products for genes affiliated with Familial Combined Hyperlipidemia

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