FHM
MCID: FML023
MIFTS: 51

Familial Hemiplegic Migraine (FHM) malady

Categories: Rare diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Familial Hemiplegic Migraine

Aliases & Descriptions for Familial Hemiplegic Migraine:

Name: Familial Hemiplegic Migraine 12 23 50 24 25 14 69
Hemiplegic Migraine, Familial 50 25 29
Hemiplegic-Ophthalmoplegic Migraine 50 25
Migraine, Familial Hemiplegic 13
Hemiplegic Migraine Familial 52
Fhm 50

Characteristics:

GeneReviews:

23
Penetrance Penetrance for fhm1, 2, and 3 appears to be high and is estimated to be approximately 80% [jurkat-rott et al 2004, riant et al 2005]...

Classifications:



External Ids:

Disease Ontology 12 DOID:0060178
ICD10 33 G43.8
ICD9CM 35 346.8
UMLS 69 C0477373

Summaries for Familial Hemiplegic Migraine

NIH Rare Diseases : 50 familial hemiplegic migraine (fhm) is a form of migraine headache that runs in families. migraines usually cause intense, throbbing pain in one area of the head, often accompanied by nausea, vomiting, and extreme sensitivity to light and sound. these recurrent headaches typically begin in childhood or adolescence and may last from a few hours to a few days. people with familial hemiplegic migraine experience an aura that comes before the headache. the most common symptoms associated with an aura are temporary visual changes such as blind spots (scotomas), flashing lights, zig-zagging lines, and double vision. in people with familial hemiplegic migraine, auras are also characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). an aura typically develops gradually over a few minutes and lasts about an hour. researchers have identified three forms of familial hemiplegic migraine known as fhm1, fhm2, and fhm3. each of the three types is caused by mutations in a different gene. treatment varies depending on signs and symptoms and may include use of anti migraine or anti seizure medications. last updated: 11/28/2016

MalaCards based summary : Familial Hemiplegic Migraine, also known as hemiplegic migraine, familial, is related to migraine, familial hemiplegic, 2 and migraine, familial hemiplegic, 3. An important gene associated with Familial Hemiplegic Migraine is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways/superpathways are Vascular smooth muscle contraction and G-Beta Gamma Signaling. The drugs Nitroglycerin and Salmon Calcitonin have been mentioned in the context of this disorder. Affiliated tissues include brain, trigeminal ganglion and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and mortality/aging

Disease Ontology : 12 A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness.

Genetics Home Reference : 25 Familial hemiplegic migraine is a form of migraine headache that runs in families. Migraines usually cause intense, throbbing pain in one area of the head, often accompanied by nausea, vomiting, and extreme sensitivity to light and sound. These recurrent headaches typically begin in childhood or adolescence and can be triggered by certain foods, emotional stress, and minor head trauma. Each headache may last from a few hours to a few days.

Wikipedia : 71 Familial hemiplegic migraine (FHM) is an autosomal dominant classical migraine subtype that typically... more...

GeneReviews: NBK1388

Related Diseases for Familial Hemiplegic Migraine

Diseases in the Hemiplegic Migraine family:

Migraine, Familial Hemiplegic, 2 Migraine, Familial Hemiplegic, 3
Migraine, Familial Hemiplegic, 1 Familial Hemiplegic Migraine
Sporadic Hemiplegic Migraine Familial or Sporadic Hemiplegic Migraine

Diseases related to Familial Hemiplegic Migraine via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
id Related Disease Score Top Affiliating Genes
1 migraine, familial hemiplegic, 2 11.9
2 migraine, familial hemiplegic, 3 11.9
3 migraine, familial hemiplegic, 1 11.9
4 alternating hemiplegia of childhood 11.7
5 hemiplegic migraine 11.6
6 episodic ataxia 11.4
7 sporadic hemiplegic migraine 11.2
8 migraine with or without aura 1 11.0
9 alternating hemiplegia of childhood 2 11.0
10 hemiplegia alterans 11.0
11 neuronitis 10.4
12 ataxia 10.3
13 epilepsy 10.2
14 cerebritis 10.2
15 cerebellar ataxia 10.2
16 encephalopathy 10.2
17 placental abruption 10.1 ATP1A2 CACNA1A
18 cockayne syndrome type i 10.1 CACNA1A CALCA
19 hemiplegia 10.0
20 atrial fibrillation and stroke 10.0 ATP1A2 CACNA1A SCN1A
21 acro-pectoro-renal dysplasia 10.0 ATP1A2 CACNA1A SCN1A
22 interstitial emphysema 10.0 ATP1A2 CACNA1A NOTCH3
23 deafness, autosomal dominant 7 10.0 ATP1A2 CACNA1A CALCA
24 cadasil 10.0
25 salpingo-oophoritis 9.9 ATP1A2 CACNA1A CALCA SCN1A
26 tonoki syndrome 9.9 ATP1A2 ATP1B1
27 infantile hypotonia 9.9 ATP1A2 CACNA1A CALCA SCN1A
28 retinitis 9.8
29 erdheim-chester disease 9.8
30 retinal degeneration 9.8
31 meningitis 9.8
32 hemicrania continua 9.8
33 migraine with aura 9.8
34 febrile seizures 9.8
35 headache 9.8
36 status epilepticus 9.8
37 microcephaly 13, primary, autosomal recessive 9.8 ATP1A2 CACNA1A CALCA NOTCH3 SCN1A
38 microscopic colitis 8.6 ATP1A2 ATP1B1 CACNA1A CALCA GNAI2 NOTCH3
39 hemorrhagic shock and encephalopathy syndrome 8.6 ATP1A2 ATP1B1 CACNA1A CALCA GNAI2 NOTCH3

Graphical network of the top 20 diseases related to Familial Hemiplegic Migraine:



Diseases related to Familial Hemiplegic Migraine

Symptoms & Phenotypes for Familial Hemiplegic Migraine

GenomeRNAi Phenotypes related to Familial Hemiplegic Migraine according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.01 NOTCH3 PRKCSH
2 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.01 PRKCSH
3 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.01 SCN5A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.01 GNAI2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.01 SCN5A
6 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.01 GNAI2 NOTCH3 SCN5A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.01 SCN5A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.01 GNAI2 NOTCH3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-158 10.01 NOTCH3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.01 SCN1A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.01 SCN1A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.01 SCN1A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.01 SCN5A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.01 SCN5A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.01 GNAI2 NOTCH3 SCN1A SCN5A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.01 SCN5A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.01 SCN1A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.01 PRKCSH
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.01 NOTCH3 SCN5A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.01 SCN5A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.01 GNAI2 NOTCH3
22 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.01 SCN1A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.01 NOTCH3 PRKCSH SCN1A

MGI Mouse Phenotypes related to Familial Hemiplegic Migraine:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.97 ATP1A2 ATP1B1 CACNA1A GNAI2 NOTCH3 OPRM1
2 behavior/neurological MP:0005386 9.95 ATP1A2 CACNA1A GNAI2 NOTCH3 OPRM1 SCN1A
3 cardiovascular system MP:0005385 9.85 ATP1A2 ATP1B1 GNAI2 NOTCH3 SCN1A SCN5A
4 nervous system MP:0003631 9.7 OPRM1 SCN1A SCN5A ATP1A2 CACNA1A GNAI2
5 muscle MP:0005369 9.65 ATP1A2 ATP1B1 CACNA1A NOTCH3 SCN5A
6 normal MP:0002873 9.56 ATP1A2 ATP1B1 CACNA1A GNAI2 NOTCH3 OPRM1
7 respiratory system MP:0005388 9.02 ATP1A2 ATP1B1 CACNA1A GNAI2 NOTCH3

Drugs & Therapeutics for Familial Hemiplegic Migraine

Drugs for Familial Hemiplegic Migraine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitroglycerin Approved, Investigational 55-63-0 4510
2
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
3
Pancrelipase Approved 53608-75-6
4 Calcitonin Gene-Related Peptide
5 calcitonin
6 Vasodilator Agents
7 Bone Density Conservation Agents
8 pancreatin

Interventional clinical trials:


id Name Status NCT ID Phase
1 Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Completed NCT00541736
2 Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2. Completed NCT00358839
3 Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2 Completed NCT00257985
4 Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA) Completed NCT00687947
5 Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines Recruiting NCT00727974

Search NIH Clinical Center for Familial Hemiplegic Migraine

Genetic Tests for Familial Hemiplegic Migraine

Genetic tests related to Familial Hemiplegic Migraine:

id Genetic test Affiliating Genes
1 Familial Hemiplegic Migraine 29 24 SCN1A

Anatomical Context for Familial Hemiplegic Migraine

MalaCards organs/tissues related to Familial Hemiplegic Migraine:

39
Brain, Trigeminal Ganglion, Testes, Kidney, Cerebellum, Thalamus

Publications for Familial Hemiplegic Migraine

Articles related to Familial Hemiplegic Migraine:

(show top 50) (show all 225)
id Title Authors Year
1
Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine. ( 27175010 )
2016
2
Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2. ( 27354390 )
2016
3
Early-onset familial hemiplegic migraine due to a novel SCN1A mutation. ( 26763045 )
2016
4
Time course of downbeat positioning nystagmus in familial hemiplegic migraine type 1 treated with acetazolamide. ( 27538634 )
2016
5
Recurrent coma and fever in familial hemiplegic migraine type 2. A prospective 15-year follow-up of a large family with a novel ATP1A2 mutation. ( 27226003 )
2016
6
A novel SCN1A mutation identified in a Chinese family with familial hemiplegic migraine: A case report. ( 27919014 )
2016
7
Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model. ( 26911348 )
2016
8
Activity-dependent calcium, oxygen, and vascular responses in a mouse model of familial hemiplegic migraine type 1. ( 27314908 )
2016
9
Familial Hemiplegic Migraine with Severe Attacks: A New Report with ATP1A2 Mutation. ( 27818813 )
2016
10
Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1. ( 27346147 )
2016
11
Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice. ( 25481823 )
2015
12
Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans. ( 25741235 )
2015
13
Biphasic neurovascular changes in prolonged migraine aura in familial hemiplegic migraine type 2. ( 25411546 )
2015
14
Perfusion and pH MRI in familial hemiplegic migraine with prolonged aura. ( 25948653 )
2015
15
Stress hormone corticosterone enhances susceptibility to cortical spreading depression in familial hemiplegic migraine type 1 mutant mice. ( 25447936 )
2015
16
Familial Hemiplegic Migraine and Recurrent Episodes of Psychosis: A Case Report. ( 26087244 )
2015
17
Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. ( 26032020 )
2015
18
Familial hemiplegic migraine type 1 associated with parkinsonism: a case report. ( 25969684 )
2015
19
An altered GABA-A receptor function in spinocerebellar ataxia type 6 and familial hemiplegic migraine type 1 associated with the CACNA1A gene mutation. ( 26675662 )
2014
20
Familial hemiplegic migraine treated by sodium valproate and lamotrigine. ( 24443394 )
2014
21
A novel ATP1A2 gene mutation in familial hemiplegic migraine and epilepsy. ( 23918834 )
2014
22
Two novel SCN1A mutations identified in families with familial hemiplegic migraine. ( 24707016 )
2014
23
Pharmacological Correction of Gating Defects in the Voltage-Gated Cav2.1 Ca(2+) Channel due to a Familial Hemiplegic Migraine Mutation. ( 24411734 )
2014
24
Repeated encephalopathy and hemicerebral atrophy in a patient with familial hemiplegic migraine type 1. ( 25274239 )
2014
25
A hyperexcitability phenotype in mouse trigeminal sensory neurons expressing the R192Q Cacna1a missense mutation of familial hemiplegic migraine type-1. ( 24583041 )
2014
26
Familial hemiplegic migraine due to L263V SCN1A mutation: Discordance for epilepsy between two kindreds from Douro Valley. ( 24646837 )
2014
27
Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i. ( 24849341 )
2014
28
Familial hemiplegic migraine: A model for the genetic studies of migraine. ( 24707017 )
2014
29
The prevalence of familial hemiplegic migraine with cerebellar ataxia and spinocerebellar ataxia type 6 in Portugal. ( 24898624 )
2014
30
Biochemical characterization of sporadic/familial hemiplegic migraine mutations. ( 24704353 )
2014
31
Familial hemiplegic migraine and spreading depression. ( 25143767 )
2014
32
Monozygotic twin sisters discordant for familial hemiplegic migraine. ( 24041236 )
2013
33
Pulmonary arterial hypertension in familial hemiplegic migraine with ATP1A2 channelopathy. ( 24136331 )
2013
34
The mechanism of functional up-regulation of P2X3 receptors of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine type 1 (FHM-1). ( 23577145 )
2013
35
Acute encephalopathy in familial hemiplegic migraine with ATP1A2 mutation. ( 23761507 )
2013
36
Clinical spectrum in three families with familial hemiplegic migraine type 2 including a novel mutation in the ATP1A2 gene. ( 24096472 )
2013
37
Nonfunctional NaV1.1 familial hemiplegic migraine mutant transformed into gain of function by partial rescue of folding defects. ( 24101488 )
2013
38
RNA expression profiling in brains of familial hemiplegic migraine type 1 knock-in mice. ( 23985897 )
2013
39
TNFI+ levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine. ( 23326332 )
2013
40
Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models. ( 23561701 )
2013
41
The familial hemiplegic migraine type 1 mutation K1336E affects direct G protein-mediated regulation of neuronal P/Q-type Ca2+ channels. ( 23430985 )
2013
42
Delayed recovery post anesthesia: an atypical presentation of familial hemiplegic migraine. ( 24347352 )
2013
43
Familial hemiplegic migraine mutations affect Na,K-ATPase domain interactions. ( 23954377 )
2013
44
Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse: A Fos protein study. ( 24355314 )
2013
45
Psychotic aura symptoms in familial hemiplegic migraine type 2 (ATP1A2). ( 22661290 )
2012
46
Stroke and familial hemiplegic migraine. ( 22608661 )
2012
47
Long-term outcome of cognitive functions, emotional behavior, and quality of life in a family with familial hemiplegic migraine. ( 22596110 )
2012
48
Variable manifestations of familial hemiplegic migraine associated with reversible cerebral edema in children. ( 22883286 )
2012
49
CaV2.1 voltage activated calcium channels and synaptic transmission in familial hemiplegic migraine pathogenesis. ( 22074995 )
2012
50
A case of familial hemiplegic migraine associated with a novel ATP1A2 gene mutation. ( 22759692 )
2012

Variations for Familial Hemiplegic Migraine

Expression for Familial Hemiplegic Migraine

Search GEO for disease gene expression data for Familial Hemiplegic Migraine.

Pathways for Familial Hemiplegic Migraine

Pathways related to Familial Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.52 ATP1A2 ATP1B1 GNAI2 SCN5A
2
Show member pathways
12.5 CACNA1A GNAI2 SCN1A SCN5A
3
Show member pathways
12.43 ATP1A2 ATP1B1 SCN1A SCN5A
4
Show member pathways
12.15 ATP1A2 ATP1B1 SCN1A SCN5A
5
Show member pathways
11.96 ATP1A2 ATP1B1 GNAI2
6
Show member pathways
11.75 ATP1B1 CACNA1A CALCA GNAI2
7
Show member pathways
11.72 ATP1A2 ATP1B1 GNAI2
8 11.53 CALCA NOTCH3 OPRM1 SCN1A SCN5A
9 11.4 ATP1A2 ATP1B1 NOTCH3
10 11.26 ATP1A2 ATP1B1
11 11.21 ATP1A2 ATP1B1
12 11.17 ATP1A2 ATP1B1
13 11.08 ATP1A2 ATP1B1
14 10.97 SCN1A SCN5A
15 10.73 ATP1A2 ATP1B1

GO Terms for Familial Hemiplegic Migraine

Cellular components related to Familial Hemiplegic Migraine according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.63 CALCA OPRM1 SCN1A
2 caveola GO:0005901 9.5 ATP1A2 ATP1B1 SCN5A
3 extracellular vesicle GO:1903561 9.43 ATP1A2 ATP1B1 GNAI2
4 voltage-gated sodium channel complex GO:0001518 9.4 SCN1A SCN5A
5 sodium:potassium-exchanging ATPase complex GO:0005890 9.37 ATP1A2 ATP1B1
6 T-tubule GO:0030315 9.33 ATP1A2 SCN1A SCN5A
7 sarcolemma GO:0042383 9.26 ATP1A2 ATP1B1 OPRM1 SCN5A
8 intercalated disc GO:0014704 8.92 ATP1A2 ATP1B1 SCN1A SCN5A
9 plasma membrane GO:0005886 10.03 ATP1A2 ATP1B1 CACNA1A GNAI2 NOTCH3 OPRM1

Biological processes related to Familial Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.78 CACNA1A SCN1A SCN5A
2 ion transport GO:0006811 9.77 ATP1A2 ATP1B1 CACNA1A SCN1A SCN5A
3 regulation of postsynaptic membrane potential GO:0060078 9.64 SCN1A SCN5A
4 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 9.64 GNAI2 OPRM1
5 ATP metabolic process GO:0046034 9.63 ATP1A2 ATP1B1
6 regulation of heart rate GO:0002027 9.63 CALCA SCN5A
7 adult walking behavior GO:0007628 9.62 CACNA1A SCN1A
8 neuronal action potential GO:0019228 9.62 SCN1A SCN5A
9 negative regulation of adenylate cyclase activity GO:0007194 9.61 GNAI2 OPRM1
10 membrane depolarization GO:0051899 9.6 CACNA1A SCN5A
11 gamma-aminobutyric acid signaling pathway GO:0007214 9.59 CACNA1A GNAI2
12 potassium ion import GO:0010107 9.58 ATP1A2 ATP1B1
13 response to pain GO:0048265 9.58 CACNA1A CALCA
14 cardiac muscle cell action potential involved in contraction GO:0086002 9.57 SCN1A SCN5A
15 cellular sodium ion homeostasis GO:0006883 9.56 ATP1A2 ATP1B1
16 ion transmembrane transport GO:0034220 9.56 ATP1A2 ATP1B1 SCN1A SCN5A
17 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.55 ATP1A2 ATP1B1
18 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.54 ATP1A2 ATP1B1
19 regulation of cardiac muscle cell contraction GO:0086004 9.52 ATP1A2 SCN5A
20 relaxation of cardiac muscle GO:0055119 9.51 ATP1A2 ATP1B1
21 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.49 ATP1A2 SCN5A
22 membrane repolarization GO:0086009 9.48 ATP1A2 ATP1B1
23 potassium ion import across plasma membrane GO:1990573 9.46 ATP1A2 ATP1B1
24 cellular potassium ion homeostasis GO:0030007 9.43 ATP1A2 ATP1B1
25 ATP hydrolysis coupled transmembrane transport GO:0090662 9.4 ATP1A2 ATP1B1
26 cardiac muscle contraction GO:0060048 9.33 ATP1A2 ATP1B1 SCN5A
27 sodium ion export from cell GO:0036376 9.32 ATP1A2 ATP1B1
28 membrane depolarization during action potential GO:0086010 9.13 CACNA1A SCN1A SCN5A
29 sodium ion transport GO:0006814 8.92 ATP1A2 ATP1B1 SCN1A SCN5A

Molecular functions related to Familial Hemiplegic Migraine according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.5 CACNA1A SCN1A SCN5A
2 voltage-gated calcium channel activity GO:0005245 9.43 CACNA1A OPRM1
3 sodium channel activity GO:0005272 9.4 SCN1A SCN5A
4 voltage-gated sodium channel activity GO:0005248 9.37 SCN1A SCN5A
5 potassium ion binding GO:0030955 9.26 ATP1A2 ATP1B1
6 sodium ion binding GO:0031402 9.16 ATP1A2 ATP1B1
7 ion channel activity GO:0005216 9.13 CACNA1A SCN1A SCN5A
8 sodium:potassium-exchanging ATPase activity GO:0005391 8.62 ATP1A2 ATP1B1

Sources for Familial Hemiplegic Migraine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
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