MCID: FML156
MIFTS: 37

Familial Hyperaldosteronism malady

Categories: Genetic diseases, Rare diseases, Endocrine diseases

Aliases & Classifications for Familial Hyperaldosteronism

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Aliases & Descriptions for Familial Hyperaldosteronism:

Name: Familial Hyperaldosteronism 25 68
Familial Primary Aldosteronism 25
Hyperaldosteronism, Familial 25
 
Hereditary Aldosteronism 25
Fh 25

Classifications:



Summaries for Familial Hyperaldosteronism

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Genetics Home Reference:25 Familial hyperaldosteronism is a group of inherited conditions in which the adrenal glands, which are small glands located on top of each kidney, produce too much of the hormone aldosterone. Aldosterone helps control the amount of salt retained by the kidneys. Excess aldosterone causes the kidneys to retain more salt than normal, which in turn increases the body's fluid levels and blood pressure. People with familial hyperaldosteronism may develop severe high blood pressure (hypertension), often early in life. Without treatment, hypertension increases the risk of strokes, heart attacks, and kidney failure.

MalaCards based summary: Familial Hyperaldosteronism, also known as familial primary aldosteronism, is related to aldosteronism, glucocorticoid-remediable and leiomyomatosis and renal cell cancer. An important gene associated with Familial Hyperaldosteronism is KCNJ5 (Potassium Voltage-Gated Channel Subfamily J Member 5), and among its related pathways are Steroid hormone biosynthesis and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. Affiliated tissues include heart, adrenal gland and kidney, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and Decreased shRNA abundance (Z-score < -2).

Wikipedia:71 Familial hyperaldosteronism is a group of inherited conditions in which the adrenal glands, which are... more...

Related Diseases for Familial Hyperaldosteronism

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Diseases in the Hyperaldosteronism family:

Hyperaldosteronism, Familial, Type Ii Hyperaldosteronism, Familial, Type Iii
Hyperaldosteronism, Familial, Type Iv familial hyperaldosteronism

Diseases related to Familial Hyperaldosteronism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
idRelated DiseaseScoreTop Affiliating Genes
1aldosteronism, glucocorticoid-remediable11.8
2leiomyomatosis and renal cell cancer11.8
3fumarase deficiency11.8
4hyperaldosteronism, familial, type iii11.3
5hyperaldosteronism, familial, type ii11.2
6hyperaldosteronism, familial, type iv10.9
7hyperaldosteronism10.5
8hypoaldosteronism, congenital, due to cmo ii deficiency10.3CYP11B1, CYP11B2
9peritoneal mesothelioma10.2CYP11B1, CYP11B2
10glioma susceptibility 110.1CYP11B1, CYP11B2
11drug-induced mental disorder10.1CYP11B1, CYP11B2, KCNJ5
12acute myocarditis10.1CYP11B1, CYP11B2, KCNJ5
13first-degree atrioventricular block10.0CYP11B1, CYP11B2
14aortic valves stenosis of the child10.0AGTR1, CYP11B2
15loeffler endocarditis10.0CYP11B1, CYP11B2, KCNJ5
16nasopharyngeal disease10.0CYP11B1, CYP11B2, KCNJ5
17neurilemmoma of the pleura10.0CYP11B1, CYP11B2, KCNJ5
18benign hypertensive renal disease9.9AGTR1, CYP11B2
19hypertension, essential9.8AGTR1, CYP11B1, CYP11B2
20retinoblastoma9.6
21cushing's syndrome9.6
22endotheliitis9.6
23adenoma9.6
24male reproductive organ benign neoplasm9.6CYP11B2, KCNJ5, MEN1
25y-linked disease9.5MEN1, PMS2
26collecting duct carcinoma9.5AGTR1, CYP11B1, CYP11B2, KCNJ5
27adrenal cortex disease9.5CYP11B1, MEN1
28cardiovascular organ benign neoplasm9.4CYP11B1, CYP11B2, KCNJ5, MEN1
29vestibular gland benign neoplasm9.4CYP11B1, CYP11B2, KCNJ5, MEN1

Graphical network of the top 20 diseases related to Familial Hyperaldosteronism:



Diseases related to familial hyperaldosteronism

Symptoms & Phenotypes for Familial Hyperaldosteronism

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GenomeRNAi Phenotypes related to Familial Hyperaldosteronism according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-359.1AGTR1, MEN1, PMS2
2GR00366-A-588.9CYP11B2, MEN1, PMS2

MGI Mouse Phenotypes related to Familial Hyperaldosteronism according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.7CYP11B1, CYP11B2, GNA12, MEN1, PMS2
2MP:00053858.2AGTR1, CYP11B1, CYP11B2, GNA12, KCNJ5, MEN1

Drugs & Therapeutics for Familial Hyperaldosteronism

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Drugs for Familial Hyperaldosteronism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Epinephrineapproved, vet_approved93351-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
2
Dopamineapproved375951-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
3Protective Agents7190
4Autonomic Agents9774
5Peripheral Nervous System Agents22776
6Racepinephrine933
7Dopamine Agents3759
8Epinephryl borate933
9Neurotransmitter Agents17734
10Mineralocorticoids352
11Hormones, Hormone Substitutes, and Hormone Antagonists12767
12Hormones13979
13Hormone Antagonists12778
14Immunoglobulins6045
15Antibodies6045
16calcitonin103
17Antihypertensive Agents4095

Interventional clinical trials:

idNameStatusNCT IDPhase
1D2 Dopamine Receptor on Human Aldosterone-Producing Adenoma and Its Role in Aldosterone Secretion and Cell ProliferationUnknown statusNCT00173446
2Cardiovascular Evaluation of Adult PHA 1 PatientsCompletedNCT00646828
3Genetic and Morphological Analysis of Thyrotoxic Periodic ParalysisActive, not recruitingNCT02287363
4Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary AldosteronismNot yet recruitingNCT02756754
5Evaluation of Safety Mechanisms of Renal Radioablation(RSRA)for Uncontrolled HypertensionTerminatedNCT01966952
6Body Volume Regulation in Pulmonary Arterial Hypertension With Right Ventricular FailureWithdrawnNCT00811486

Search NIH Clinical Center for Familial Hyperaldosteronism

Genetic Tests for Familial Hyperaldosteronism

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Anatomical Context for Familial Hyperaldosteronism

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MalaCards organs/tissues related to Familial Hyperaldosteronism:

36
Heart, Adrenal gland, Kidney, Testes, Endothelial

Publications for Familial Hyperaldosteronism

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Articles related to Familial Hyperaldosteronism:

(show all 47)
idTitleAuthorsYear
1
Disordered zonal and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3. (27793677)
2017
2
Evaluation of a Recently Established Test for Familial Hyperaldosteronism Type 1. (27923252)
2016
3
A novel phenotype of familial hyperaldosteronism type III: Concurrence of aldosteronism and Cushing's syndrome. (27403928)
2016
4
An Update on Familial Hyperaldosteronism. (26445452)
2015
5
Discordant genotype-phenotype correlation in familial hyperaldosteronism type III with KCNJ5 gene mutation: a patient report and review of the literature. (24819081)
2014
6
Pregnancy normalized familial hyperaldosteronism type I: a novel role for progesterone? (24943290)
2014
7
a Novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III. (24037882)
2013
8
The prevalence of familial hyperaldosteronism in apparently sporadic primary aldosteronism in Germany: a single center experience. (22274719)
2012
9
KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism. (22203740)
2012
10
Polyuric-polydipsic syndrome in a pediatric case of non-glucocorticoid remediable familial hyperaldosteronism. (22447138)
2012
11
Frequency of familial hyperaldosteronism type 1 in a hypertensive pediatric population: clinical and biochemical presentation. (21502562)
2011
12
Further study of chromosome 7p22 to identify the molecular basis of familial hyperaldosteronism type II. (20927129)
2011
13
A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I. (20634641)
2011
14
Is familial hyperaldosteronism underdiagnosed in hypertensive children? (21502569)
2011
15
Prevalence and characteristics of familial hyperaldosteronism: the PATOGEN study (Primary Aldosteronism in TOrino-GENetic forms). (21876069)
2011
16
Familial hyperaldosteronism I-III. (20131203)
2010
17
A mother/daughter case of familial hyperaldosteronism. (20865750)
2010
18
Familial hyperaldosteronism type 1 in pregnancy. (19356193)
2009
19
Elevated serum interleukin 6 levels in normotensive individuals with familial hyperaldosteronism type 1. (19221206)
2009
20
Further evidence for linkage of familial hyperaldosteronism type II at chromosome 7p22 in Italian as well as Australian and South American families. (18622235)
2008
21
Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II. (18307725)
2008
22
A new form of hereditary primary aldosteronism: familial hyperaldosteronism type III. (18685118)
2008
23
Subclinical endothelial inflammation markers in a family with type I familial hyperaldosteronism caused by a de novo mutation]. (19030657)
2008
24
No evidence for coding region mutations in the retinoblastoma-associated Kruppel-associated box protein gene (RBaK) causing familial hyperaldosteronism type II. (17121540)
2006
25
Familial hyperaldosteronism type II is linked to the chromosome 7p22 region but also shows predicted heterogeneity. (16003173)
2005
26
Evidence for abnormal left ventricular structure and function in normotensive individuals with familial hyperaldosteronism type I. (15941863)
2005
27
Genomic structure of the human gene for protein kinase A regulatory subunit R1-beta (PRKAR1B) on 7p22: no evidence for mutations in familial hyperaldosteronism type II in a large affected kindred. (15579186)
2004
28
Familial hyperaldosteronism]. (15351948)
2004
29
Retention of heterozygosity at chromosome 7p22 and 11q13 in aldosterone-producing tumours of patients with familial hyperaldosteronism not remediable by glucocorticoids. (15175634)
2004
30
New genetic insights in familial hyperaldosteronism. (12381543)
2002
31
Familial hyperaldosteronism. (11595502)
2001
32
A chimeric CYP11B1/CYP11B2 gene in glucocorticoid-insuppressible familial hyperaldosteronism. (11453962)
2001
33
Treatment of familial hyperaldosteronism type I: only partial suppression of adrenocorticotropin required to correct hypertension. (10999827)
2000
34
Severity of hypertension in familial hyperaldosteronism type I: relationship to gender and degree of biochemical disturbance. (10852446)
2000
35
A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22). (11073536)
2000
36
Familial hyperaldosteronism. (11004715)
2000
37
Biochemical evidence of aldosterone overproduction and abnormal regulation in normotensive individuals with familial hyperaldosteronism type I. (10566645)
1999
38
Linkage analysis of familial hyperaldosteronism type II--absence of linkage to the gene encoding the angiotensin II receptor type 1. (9506777)
1998
39
Familial hyperaldosteronism type II: description of a large kindred and exclusion of the aldosterone synthase (CYP11B2) gene. (9745430)
1998
40
Evidence for persistent dysfunction of wild-type aldosterone synthase gene in glucocorticoid-treated familial hyperaldosteronism type I. (9488230)
1997
41
In familial hyperaldosteronism type I, hybrid gene-induced aldosterone production dominates that induced by wild-type genes. (9360524)
1997
42
A PCR-based method of screening individuals of all ages, from neonates to the elderly, for familial hyperaldosteronism type I. (9483237)
1997
43
Hybrid gene or hybrid steroids in the detection and screening for familial hyperaldosteronism type I. (8582097)
1995
44
Clinical, biochemical and genetic approaches to the detection of familial hyperaldosteronism type I. (8903619)
1995
45
A new genetic test for familial hyperaldosteronism type I aids in the detection of curable hypertension. (7864844)
1995
46
Familial hyperaldosteronism type II: five families with a new variety of primary aldosteronism. (1521363)
1992
47
Familial hyperaldosteronism, not suppressed by dexamethasone. (7119083)
1982

Variations for Familial Hyperaldosteronism

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Clinvar genetic disease variations for Familial Hyperaldosteronism:

5
id Gene Variation Type Significance SNP ID Assembly Location
1KCNJ5NM_000890.3(KCNJ5): c.1159G> C (p.Gly387Arg)SNVPathogenicrs199830292GRCh37Chr 11, 128786525: 128786525

Expression for genes affiliated with Familial Hyperaldosteronism

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Search GEO for disease gene expression data for Familial Hyperaldosteronism.

Pathways for genes affiliated with Familial Hyperaldosteronism

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Pathways related to Familial Hyperaldosteronism according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8CYP11B1, CYP11B2
2
Show member pathways
9.6AGTR1, CYP11B2
3
Show member pathways
9.2AGTR1, GNA12, KCNJ5

GO Terms for genes affiliated with Familial Hyperaldosteronism

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Biological processes related to Familial Hyperaldosteronism according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1aldosterone biosynthetic processGO:003234210.4CYP11B1, CYP11B2
2C21-steroid hormone biosynthetic processGO:000670010.4CYP11B1, CYP11B2
3cellular response to hormone stimulusGO:003287010.3CYP11B1, CYP11B2
4cellular response to potassium ionGO:003586510.3CYP11B1, CYP11B2
5cholesterol metabolic processGO:000820310.3CYP11B1, CYP11B2
6cortisol biosynthetic processGO:003465110.3CYP11B1, CYP11B2
7secondary metabolite biosynthetic processGO:004455010.1CYP11B1, CYP11B2
8Rho protein signal transductionGO:00072669.9AGTR1, GNA12
9cellular response to peptide hormone stimulusGO:00713759.8CYP11B1, CYP11B2, MEN1
10sterol metabolic processGO:00161259.8CYP11B1, CYP11B2

Molecular functions related to Familial Hyperaldosteronism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1corticosterone 18-monooxygenase activityGO:004778310.1CYP11B1, CYP11B2
2steroid 11-beta-monooxygenase activityGO:00045079.8CYP11B1, CYP11B2
3oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygenGO:00167099.7CYP11B1, CYP11B2

Sources for Familial Hyperaldosteronism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet