MCID: FML187
MIFTS: 23

Familial Hypertension malady

Genetic diseases category

Summaries for Familial Hypertension

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Sources:
63Wikipedia, 32MalaCards
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Wikipedia:63 Essential hypertension (also called primary hypertension or idiopathic hypertension) is the form of... more...

MalaCards: Familial Hypertension is related to hypertension and myocardial infarction. An important gene associated with Familial Hypertension is ACTA2 (actin, alpha 2, smooth muscle, aorta), and among its related pathways are Adipogenesis and Insulin Processing. The compounds palmitate and olmesartan have been mentioned in the context of this disorder.

Aliases & Classifications for Familial Hypertension

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Sources:
42NIH Rare Diseases, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases


Aliases & Descriptions:

familial hypertension 42 60


Related Diseases for Familial Hypertension

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hypertension family:

Benign Essential Hypertension Malignant Essential Hypertension
Essential Hypertension Malignant Hypertension
familial hypertension Hypertension, Essential 3
Hypertension, Essential 7 Hypertension, Essential 6
Hypertension, Essential 4 Hypertension, Essential 2
Hypertension, Essential 1 Hypertension, Essential 8
Hypertension, Essential 5

Diseases related to Familial Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.7ALB, INS, AGT
2myocardial infarction29.8AGT
3renal hypertension10.0
4pseudohypoaldosteronism type ii10.0
5acromegaly10.0INS
6hypoglycemia10.0INS
7metabolic syndrome x10.0INS
8aortic aneurysm10.0ACTA2
9diabetic ketoacidosis10.0INS
10thyrotoxicosis10.0INS
11hypokalemia10.0INS
12cholera10.0INS
13proliferative diabetic retinopathy10.0AGT
14hyperuricemia10.0INS
15alzheimer's disease10.0INS
16blindness10.0INS
17acute myocardial infarction10.0AGT
18eating disorder10.0INS
19growth hormone deficiency10.0INS
20primary hyperoxaluria10.0AGT
21glomerulonephritis10.0ALB
22uremia10.0ALB
23vasculitis10.0ALB
24hepatitis b10.0ALB
25lactic acidosis10.0INS
26ovarian hyperstimulation syndrome10.0ALB
27pulmonary embolism10.0ALB
28ulcerative colitis10.0ALB
29peritonitis10.0ALB
30glucose intolerance10.0INS
31lung cancer10.0ALB
32metabolic acidosis10.0ALB
33hypercholesterolemia10.0AGT, INS
34hyperhomocysteinemia10.0ALB
35coronary heart disease10.0INS, AGT
36acquired immunodeficiency syndrome10.0ALB
37familial hyperlipidemia10.0INS, AGT
38stroke, ischemic10.0ALB, INS
39ischemia10.0AGT
40autonomic neuropathy10.0INS, ALB
41peripheral vascular disease10.0ALB, INS
42cork-handlers' disease10.0INS, ALB
43nephrotic syndrome10.0ALB, AGT
44liver cirrhosis10.0ALB, AGT
45focal segmental glomerulosclerosis10.0ALB, AGT
46iga glomerulonephritis10.0ALB, AGT
47neuropathy10.0ALB, INS
48galactosemia10.0ALB, INS
49hyperinsulinism10.0AGT, INS
50congenital heart defect10.0AGT, INS, ALB

Graphical network of the top 20 diseases related to Familial Hypertension:



Diseases related to familial hypertension

Clinical Features for Familial Hypertension

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Drugs & Therapeutics for Familial Hypertension

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Familial Hypertension

Drug clinical trials:

Search ClinicalTrials for Familial Hypertension

Search NIH Clinical Center for Familial Hypertension

Search CenterWatch for Familial Hypertension

Genetic Tests for Familial Hypertension

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Anatomical Context for Familial Hypertension

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Animal Models for Familial Hypertension or affiliated genes

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Publications for Familial Hypertension

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Genetic Variations for Familial Hypertension

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Expression for genes affiliated with Familial Hypertension

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Hypertension

Search GEO for disease gene expression data for Familial Hypertension.

Pathways for genes affiliated with Familial Hypertension

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Sources:
37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Pathways related to Familial Hypertension according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3INS, AGT
2
Hide members
9.3AGT, INS
39.1ALB, INS
49.1ALB, INS
59.1ALB, INS

Compounds for genes affiliated with Familial Hypertension

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Familial Hypertension according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1palmitate449.9INS
2olmesartan44 28 1111.7AGT, INS
3nn304449.5ALB, INS
4c-peptide449.5AGT, INS
5fructosamine44 2410.5ALB, INS
6repaglinide44 49 1111.5ALB, INS
7ramipril44 1110.5INS, ALB
8gliclazide44 49 1111.5ALB, INS
9nateglinide44 49 1111.5ALB, INS
10inulin449.4ALB, AGT
11lisinopril44 11 2411.4ALB, AGT
12rosuvastatin44 49 28 1112.4INS, ALB
13valsartan44 59 28 1112.4ALB, AGT
14perindopril44 49 1111.4AGT, ALB
15irbesartan44 28 49 1112.3ALB, AGT
16olanzapine49 44 28 11 2413.3ALB, INS
17hydrochlorothiazide44 49 28 11 2413.3AGT, ALB
18candesartan44 28 1111.3ALB, AGT
19enalapril44 49 1111.3ALB, AGT
20amlodipine44 49 11 2412.3ALB, AGT
21myristic acid44 11 2411.2INS, ALB
22losartan44 49 28 1112.1ALB, AGT
23uric acid44 2410.1ALB, INS
24rosiglitazone44 49 28 11 2413.1ALB, INS
25telmisartan44 28 1110.9ALB, INS, AGT
26fibrinogen448.8ALB, INS, AGT
27homocysteine44 249.7ALB, AGT
28creatinine448.7ALB, INS, AGT
29cholesterol44 28 11 2411.7ALB, INS, AGT

GO Terms for genes affiliated with Familial Hypertension

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Sources:
16Gene Ontology
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Cellular components related to Familial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5ALB, INS, AGT

Biological processes related to Familial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cellular protein metabolic processGO:0322709.4INS, AGT
2positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.3INS, AGT
3positive regulation of NF-kappaB transcription factor activityGO:0510929.3INS, AGT
4positive regulation of MAPK cascadeGO:0434109.2AGT, INS
5positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.0INS, AGT

Molecular functions related to Familial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.3INS, AGT

Products for genes affiliated with Familial Hypertension

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Familial Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet