MCID: FML187
MIFTS: 36

Familial Hypertension malady

Genetic diseases, Rare diseases, Cardiovascular diseases, Blood diseases categories

Summaries for Familial Hypertension

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66Wikipedia, 34MalaCards
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Wikipedia:66 Essential hypertension (also called primary hypertension or idiopathic hypertension) is the form of... more...

MalaCards: Familial Hypertension is related to hypertension and pseudohypoaldosteronism type ii. An important gene associated with Familial Hypertension is AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)), and among its related pathways are Adipogenesis and Peptide hormone metabolism. The compounds olmesartan and c-peptide have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are muscle and liver/biliary system.

Aliases & Classifications for Familial Hypertension

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44NIH Rare Diseases, 63UMLS
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Classifications:



Aliases & Descriptions:

familial hypertension 44 63


Related Diseases for Familial Hypertension

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Hypertension family:

Benign Essential Hypertension Malignant Essential Hypertension
Essential Hypertension Malignant Hypertension
familial hypertension Hypertension, Essential 3
Hypertension, Essential 7 Hypertension, Essential 6
Hypertension, Essential 4 Hypertension, Essential 2
Hypertension, Essential 1 Hypertension, Essential 8
Hypertension, Essential 5

Diseases related to Familial Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.7AGT, ALB, INS
2pseudohypoaldosteronism type ii10.0
3familial hyperlipidemia10.0INS, AGT
4hypercholesterolemia10.0AGT, INS
5hyperinsulinism10.0INS, AGT
6peripheral vascular disease10.0ALB, INS
7autonomic neuropathy10.0INS, ALB
8cork-handlers' disease10.0ALB, INS
9stroke, ischemic10.0ALB, INS
10diarrhea10.0ALB, INS
11vascular disease10.0AGT, INS
12primary hyperoxaluria10.0INS, ALB
13hypersensitivity reaction type ii disease10.0ALB, INS
14pancreatitis10.0ALB, INS
15glomerulosclerosis10.0AGT, ALB
16iga glomerulonephritis10.0ALB, AGT
17neuropathy10.0INS, ALB
18nephrotic syndrome10.0ALB, AGT
19coronary artery disease10.0INS, AGT
20obesity10.0INS, AGT
21liver cirrhosis10.0ALB, AGT
22galactosemia10.0ALB, INS
23diabetic retinopathy9.9AGT, INS, ALB
24congenital heart disease9.9AGT, INS, ALB
25essential hypertension9.9AGT, ALB, INS
26diabetic nephropathy9.9AGT, ALB, INS
27proteinuria9.9AGT, INS, ALB
28type 1 diabetes mellitus9.9INS, ALB, AGT
29hyperglycemia9.9ALB, AGT, INS
30chronic kidney failure9.9AGT, ALB, INS
31type 2 diabetes mellitus9.9AGT, INS, ALB
32insulin resistance9.9ALB, INS, AGT
33diabetes mellitus9.9INS, AGT, ALB
34atherosclerosis9.9AGT, INS, ALB
35cystic fibrosis9.9INS, ALB
36breast cancer9.9ALB, AGT, INS
37pseudohypoaldosteronism9.9
38myocardial infarction9.9
39hyperekplexia9.9
40hypertensive hypokalemia familial9.9

Graphical network of the top 20 diseases related to Familial Hypertension:



Diseases related to familial hypertension

Symptoms for Familial Hypertension

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Drugs & Therapeutics for Familial Hypertension

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Familial Hypertension

Drug clinical trials:

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Genetic Tests for Familial Hypertension

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Anatomical Context for Familial Hypertension

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34MalaCards
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MalaCards organs/tissues related to Familial Hypertension:

34
Kidney

Animal Models for Familial Hypertension or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Familial Hypertension:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5AGT, ALB, INS
2MP:00053708.4AGT, ALB, INS
3MP:00053678.2AGT, ALB, INS

Publications for Familial Hypertension

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53PubMed
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Articles related to Familial Hypertension:

(show all 21)
idTitleAuthorsYear
1
The polymorphism of angiotensin-receptor gene A1166C in familial hypertension and its distribution in the Han Yellow race of China. (24145933)
2013
2
An inducible transgenic mouse model for familial hypertension with hyperkalaemia (Gordon's syndrome or pseudohypoaldosteronism type II). (23336180)
2013
3
Renal FMD may not confer a familial hypertensive risk nor is it caused by ACTA2 mutations. (21553326)
2011
4
The metabolic syndrome and risk of myocardial infarction in familial hypertension (hypertension heredity in MalmAP evaluation study). (19050451)
2009
5
The effects of exercise on haemodynamic function in relation to the familial hypertension risk model. (16496017)
2006
6
Spironolactone responsive familial hypertension. A potentially high prevalence of mineralocorticoid disease in Oman. (12682699)
2003
7
Influence of familial hypertension on blood pressure, serum cholesterol, high density lipoprotein cholesterol during second and third decade of life in Punjabi population. (15255633)
2003
8
High urinary excretion of uric acid combined with high excretion of calcium links kidney stone disease to familial hypertension. (11812875)
2002
9
Effect of familial hypertension on glomerular hemodynamics and tubulo-glomerular feedback after uninephrectomy. (11243302)
2001
10
Abnormalities in insulin sensitivity, vascular resistance and erythrocyte cation transport are independent genetic traits in familial hypertension. (10451037)
1999
11
Familial hypertension, insulin, sympathetic activity, and blood pressure elevation. (9674644)
1998
12
Association of M235T variant of the angiotensinogen gene with familial hypertension of early onset. (7478115)
1995
13
Familial hypertension in Morgagni's De Sedibus et Causis Morborum per Anatomen Indagatis. (7847481)
1994
14
Familial hypertension and albuminuria in normotensive type I diabetic patients. (8282370)
1994
15
Cross-sectional analysis of Met235-->Thr variant of angiotensinogen gene in severe, familial hypertension. (8267622)
1993
16
Influence of familial hypertension of the donor on the blood pressure and antihypertensive therapy of kidney graft recipients. (7050749)
1982
17
Influence of familial hypertension on blood pressure during adolescence. (6975038)
1981
18
Familial hypertension and hormonal profile, renal haemodynamics and body fluids of young normotensive subjects. (282088)
1978
19
Familial hypertension. (1185030)
1975
20
Chronic hypertension following pre-eclamptic toxaemia: the influence of familial hypertension on its causation. (13564280)
1958
21
Chronic hypertension following pre-eclamptic toxaemia; the influence of familial hypertension on its causation. (13367916)
1956

Variations for Familial Hypertension

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Expression for genes affiliated with Familial Hypertension

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Hypertension

Search GEO for disease gene expression data for Familial Hypertension.

Pathways for genes affiliated with Familial Hypertension

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 13EMD Millipore, 31KEGG
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Pathways related to Familial Hypertension according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3INS, AGT
2
Show member pathways
9.3AGT, INS
3
Show member pathways
9.3AGT, INS
4
Show member pathways
thioredoxin pathway39
9.1ALB, INS
59.1INS, ALB
69.1ALB, INS
7
Show member pathways
8.5AGT, ALB, INS

Compounds for genes affiliated with Familial Hypertension

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 25HMDB, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Familial Hypertension according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1olmesartan46 30 1211.8AGT, INS
2c-peptide469.7INS, AGT
3acth469.6AGT, INS
4nn304469.6ALB, INS
5epinephrine46 25 1211.6AGT, INS
6fructosamine46 2510.6ALB, INS
7repaglinide52 46 1211.6ALB, INS
8ramipril46 1210.6INS, ALB
9nateglinide46 52 1211.5ALB, INS
10gliclazide46 52 1211.5ALB, INS
11norepinephrine46 25 1211.5AGT, INS
12rapamycin469.5AGT, INS
13rosuvastatin46 52 30 1212.5ALB, INS
14olanzapine46 52 30 25 1213.5ALB, INS
15ly294002469.5INS, AGT
16myristic acid46 25 1211.5INS, ALB
17inulin469.5ALB, AGT
18uric acid46 2510.5ALB, INS
19lisinopril46 52 25 1212.5AGT, ALB
20palmitate469.5INS, ALB
21wortmannin469.4AGT, INS
22valsartan46 62 30 1212.4ALB, AGT
23perindopril46 52 1211.4AGT, ALB
24irbesartan46 30 52 1212.4AGT, ALB
25candesartan46 52 30 1212.4AGT, ALB
26rosiglitazone30 46 52 25 1213.4ALB, INS
27hydrochlorothiazide46 30 52 25 1213.4AGT, ALB
28amlodipine46 52 25 1212.4ALB, AGT
29enalapril46 52 1211.4ALB, AGT
30thyroxine46 2510.4ALB, INS
31tacrolimus46 52 1211.4INS, ALB
32captopril46 62 52 30 1213.4AGT, ALB
33losartan46 52 30 1212.4AGT, ALB
34homocysteine46 2510.3AGT, ALB
35indomethacin46 30 62 1212.3ALB, AGT
36lactate469.1ALB, INS
37potassium46 25 1211.1AGT, ALB
38estradiol46 25 1211.0ALB, AGT
39telmisartan46 30 1211.0AGT, ALB, INS
40fibrinogen468.9INS, ALB, AGT
41arachidonic acid46 30 25 1211.9AGT, ALB
42creatinine468.9INS, ALB, AGT
43cholesterol46 30 25 1211.9INS, ALB, AGT
44glucose468.8AGT, ALB, INS
45fatty acid468.8ALB, INS
46lipid468.8INS, ALB, AGT

GO Terms for genes affiliated with Familial Hypertension

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17Gene Ontology
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Cellular components related to Familial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725628.7AGT, ALB
2extracellular regionGO:0055768.5AGT, ALB, INS
3extracellular spaceGO:0056158.4AGT, ALB, INS

Biological processes related to Familial Hypertension according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cellular protein metabolic processGO:0322709.5AGT, INS
2positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.5AGT, INS
3positive regulation of MAPK cascadeGO:0434109.4AGT, INS
4positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4AGT, INS
5positive regulation of NF-kappaB transcription factor activityGO:0510929.3INS, AGT
6G-protein coupled receptor signaling pathwayGO:0071869.3AGT, INS
7cell-cell signalingGO:0072679.0AGT, INS
8small molecule metabolic processGO:0442818.4AGT, ALB, INS

Molecular functions related to Familial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.3AGT, INS

Products for genes affiliated with Familial Hypertension

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Familial Hypertension

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet