MCID: FML187
MIFTS: 29

Familial Hypertension malady

Genetic diseases, Rare diseases, Cardiovascular diseases, Blood diseases categories

Aliases & Classifications for Familial Hypertension

About this section

Familial Hypertension, Aliases & Descriptions:

Name: Familial Hypertension 41 60


Classifications:



Summaries for Familial Hypertension

About this section


MalaCards based summary: Familial Hypertension is related to familial hyperlipidemia and hypercholesterolemia, familial. An important gene associated with Familial Hypertension is AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)), and among its related pathways are Peptide hormone metabolism and p70S6K Signaling. The compounds olmesartan and c-peptide have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are muscle and liver/biliary system.

Related Diseases for Familial Hypertension

About this section

Diseases in the Familial Hypertension family:

Hypertension, Essential Benign Essential Hypertension
Malignant Essential Hypertension Benign Secondary Hypertension
Malignant Hypertension Malignant Secondary Hypertension

Diseases related to Familial Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1familial hyperlipidemia10.1INS, AGT
2hypercholesterolemia, familial10.1AGT, INS
3pseudohypoaldosteronism, type iie10.0
4hyperinsulinism10.0INS, AGT
5peripheral vascular disease10.0ALB, INS
6autonomic neuropathy10.0INS, ALB
7cork-handlers' disease10.0ALB, INS
8stroke, ischemic10.0ALB, INS
9diarrhea10.0ALB, INS
10vascular disease10.0AGT, INS
11primary hyperoxaluria10.0INS, ALB
12hypersensitivity reaction type ii disease10.0ALB, INS
13pancreatitis10.0ALB, INS
14liver disease10.0INS, ALB
15glomerulosclerosis10.0AGT, ALB
16iga glomerulonephritis10.0ALB, AGT
17neuropathy10.0INS, ALB
18nephrotic syndrome10.0ALB, AGT
19coronary artery disease10.0INS, AGT
20obesity10.0INS, AGT
21liver cirrhosis9.9ALB, AGT
22myocardial infarction9.9
23pseudohypoaldosteronism9.9
24hyperekplexia9.9
25hypertensive hypokalemia familial9.9
26galactosemia9.8ALB, INS
27microvascular complications of diabetes 59.8AGT, INS, ALB
28congenital heart disease9.8AGT, INS, ALB
29microvascular complications of diabetes 39.8AGT, ALB, INS
30proteinuria9.8AGT, INS, ALB
31hypertension, essential9.8AGT, ALB, INS
32hyperglycemia9.8ALB, AGT, INS
33chronic kidney failure9.8AGT, ALB, INS
34diabetes mellitus, noninsulin-dependent9.8ALB, INS, AGT
35diabetes mellitus, insulin-dependent9.8INS, AGT, ALB
36atherosclerosis9.8AGT, INS, ALB
37cystic fibrosis9.7INS, ALB
38breast cancer9.6ALB, AGT, INS

Graphical network of the top 20 diseases related to Familial Hypertension:



Diseases related to familial hypertension

Symptoms for Familial Hypertension

About this section

Drugs & Therapeutics for Familial Hypertension

About this section

Drug clinical trials:

Search ClinicalTrials for Familial Hypertension

Search NIH Clinical Center for Familial Hypertension

Genetic Tests for Familial Hypertension

About this section

Anatomical Context for Familial Hypertension

About this section

MalaCards organs/tissues related to Familial Hypertension:

31
Kidney

Animal Models for Familial Hypertension or affiliated genes

About this section

MGI Mouse Phenotypes related to Familial Hypertension:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5AGT, ALB, INS
2MP:00053708.4AGT, ALB, INS
3MP:00053678.2AGT, ALB, INS

Publications for Familial Hypertension

About this section

Articles related to Familial Hypertension:

(show all 21)
idTitleAuthorsYear
1
The polymorphism of angiotensin-receptor gene A1166C in familial hypertension and its distribution in the Han Yellow race of China. (24145933)
2013
2
An inducible transgenic mouse model for familial hypertension with hyperkalaemia (Gordon's syndrome or pseudohypoaldosteronism type II). (23336180)
2013
3
Renal FMD may not confer a familial hypertensive risk nor is it caused by ACTA2 mutations. (21553326)
2011
4
The metabolic syndrome and risk of myocardial infarction in familial hypertension (hypertension heredity in MalmAP evaluation study). (19050451)
2009
5
The effects of exercise on haemodynamic function in relation to the familial hypertension risk model. (16496017)
2006
6
Spironolactone responsive familial hypertension. A potentially high prevalence of mineralocorticoid disease in Oman. (12682699)
2003
7
Influence of familial hypertension on blood pressure, serum cholesterol, high density lipoprotein cholesterol during second and third decade of life in Punjabi population. (15255633)
2003
8
High urinary excretion of uric acid combined with high excretion of calcium links kidney stone disease to familial hypertension. (11812875)
2002
9
Effect of familial hypertension on glomerular hemodynamics and tubulo-glomerular feedback after uninephrectomy. (11243302)
2001
10
Abnormalities in insulin sensitivity, vascular resistance and erythrocyte cation transport are independent genetic traits in familial hypertension. (10451037)
1999
11
Familial hypertension, insulin, sympathetic activity, and blood pressure elevation. (9674644)
1998
12
Association of M235T variant of the angiotensinogen gene with familial hypertension of early onset. (7478115)
1995
13
Familial hypertension in Morgagni's De Sedibus et Causis Morborum per Anatomen Indagatis. (7847481)
1994
14
Familial hypertension and albuminuria in normotensive type I diabetic patients. (8282370)
1994
15
Cross-sectional analysis of Met235-->Thr variant of angiotensinogen gene in severe, familial hypertension. (8267622)
1993
16
Influence of familial hypertension of the donor on the blood pressure and antihypertensive therapy of kidney graft recipients. (7050749)
1982
17
Influence of familial hypertension on blood pressure during adolescence. (6975038)
1981
18
Familial hypertension and hormonal profile, renal haemodynamics and body fluids of young normotensive subjects. (282088)
1978
19
Familial hypertension. (1185030)
1975
20
Chronic hypertension following pre-eclamptic toxaemia: the influence of familial hypertension on its causation. (13564280)
1958
21
Chronic hypertension following pre-eclamptic toxaemia; the influence of familial hypertension on its causation. (13367916)
1956

Variations for Familial Hypertension

About this section

Expression for genes affiliated with Familial Hypertension

About this section
Search GEO for disease gene expression data for Familial Hypertension.

Pathways for genes affiliated with Familial Hypertension

About this section

Pathways related to Familial Hypertension according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3AGT, INS
2
Show member pathways
9.3AGT, INS
39.3AGT, INS
4
Show member pathways
thioredoxin pathway36
9.1INS, ALB
59.1ALB, INS
6
Show member pathways
8.5AGT, ALB, INS

Compounds for genes affiliated with Familial Hypertension

About this section

Compounds related to Familial Hypertension according to GeneCards Suite gene sharing:

(show all 46)
idCompoundScoreTop Affiliating Genes
1olmesartan43 28 1211.8AGT, INS
2c-peptide439.7INS, AGT
3acth439.6AGT, INS
4nn304439.6ALB, INS
5epinephrine43 24 1211.6AGT, INS
6fructosamine43 2410.6ALB, INS
7repaglinide49 43 1211.6ALB, INS
8ramipril43 1210.6INS, ALB
9nateglinide43 49 1211.5ALB, INS
10gliclazide43 49 1211.5ALB, INS
11norepinephrine43 24 1211.5AGT, INS
12rapamycin439.5AGT, INS
13rosuvastatin43 49 28 1212.5ALB, INS
14olanzapine43 49 28 24 1213.5ALB, INS
15ly294002439.5INS, AGT
16myristic acid43 24 1211.5INS, ALB
17inulin439.5ALB, AGT
18uric acid43 2410.5ALB, INS
19lisinopril43 49 24 1212.5AGT, ALB
20palmitate439.5INS, ALB
21wortmannin439.4AGT, INS
22valsartan43 59 28 1212.4ALB, AGT
23perindopril43 49 1211.4AGT, ALB
24irbesartan43 28 49 1212.4AGT, ALB
25candesartan43 49 28 1212.4AGT, ALB
26rosiglitazone28 43 49 24 1213.4ALB, INS
27hydrochlorothiazide43 28 49 24 1213.4AGT, ALB
28amlodipine43 49 24 1212.4ALB, AGT
29enalapril43 49 1211.4ALB, AGT
30thyroxine43 2410.4ALB, INS
31tacrolimus43 49 1211.4INS, ALB
32captopril43 59 49 28 1213.4AGT, ALB
33losartan43 49 28 1212.4AGT, ALB
34homocysteine43 2410.3AGT, ALB
35indomethacin43 28 59 1212.3ALB, AGT
36lactate439.1ALB, INS
37potassium43 24 1211.1AGT, ALB
38estradiol43 24 1211.0ALB, AGT
39telmisartan43 28 1211.0AGT, ALB, INS
40fibrinogen438.9INS, ALB, AGT
41arachidonic acid43 28 24 1211.9AGT, ALB
42creatinine438.9INS, ALB, AGT
43cholesterol43 28 24 1211.9INS, ALB, AGT
44glucose438.8AGT, ALB, INS
45fatty acid438.8ALB, INS
46lipid438.8INS, ALB, AGT

GO Terms for genes affiliated with Familial Hypertension

About this section

Cellular components related to Familial Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725628.7AGT, ALB
2extracellular regionGO:00055768.5AGT, ALB, INS
3extracellular spaceGO:00056158.4AGT, ALB, INS

Biological processes related to Familial Hypertension according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cellular protein metabolic processGO:00322709.5AGT, INS
2positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.5AGT, INS
3positive regulation of MAPK cascadeGO:00434109.4AGT, INS
4positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.4AGT, INS
5positive regulation of NF-kappaB transcription factor activityGO:00510929.3INS, AGT
6G-protein coupled receptor signaling pathwayGO:00071869.3AGT, INS
7cell-cell signalingGO:00072679.0AGT, INS
8small molecule metabolic processGO:00442818.4AGT, ALB, INS

Molecular functions related to Familial Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.3AGT, INS

Products for genes affiliated with Familial Hypertension

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Familial Hypertension

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet