MCID: FML187
MIFTS: 36

Familial Hypertension malady

Genetic diseases, Rare diseases, Cardiovascular diseases, Blood diseases categories
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Summaries for Familial Hypertension

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Wikipedia:65 Essential hypertension (also called primary hypertension or idiopathic hypertension) is the form of... more...

MalaCards based summary: Familial Hypertension is related to hypertension and familial hyperlipidemia. An important gene associated with Familial Hypertension is AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)), and among its related pathways are Peptide hormone metabolism and p70S6K Signaling. The compounds olmesartan and c-peptide have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are muscle and liver/biliary system.

Aliases & Classifications for Familial Hypertension

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Familial Hypertension, Aliases & Descriptions:

Name: Familial Hypertension 42 62


Classifications:



Related Diseases for Familial Hypertension

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Diseases in the Hypertension family:

Benign Essential Hypertension Malignant Essential Hypertension
Essential Hypertension Malignant Hypertension
familial hypertension Hypertension, Essential 3
Hypertension, Essential 7 Hypertension, Essential 6
Hypertension, Essential 4 Hypertension, Essential 2
Hypertension, Essential 1 Hypertension, Essential 8
Hypertension, Essential 5

Diseases related to Familial Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.5INS, ALB, AGT
2familial hyperlipidemia10.1AGT, INS
3hypercholesterolemia10.1INS, AGT
4hyperinsulinism10.1AGT, INS
5pseudohypoaldosteronism type ii10.0
6peripheral vascular disease10.0ALB, INS
7autonomic neuropathy10.0ALB, INS
8cork-handlers' disease10.0ALB, INS
9stroke, ischemic10.0ALB, INS
10diarrhea10.0INS, ALB
11vascular disease10.0AGT, INS
12primary hyperoxaluria10.0ALB, INS
13hypersensitivity reaction type ii disease10.0INS, ALB
14pancreatitis10.0ALB, INS
15glomerulosclerosis10.0AGT, ALB
16berger disease10.0AGT, ALB
17neuropathy10.0ALB, INS
18nephrotic syndrome10.0AGT, ALB
19coronary artery anomaly10.0AGT, INS
20obesity10.0AGT, INS
21liver cirrhosis9.9AGT, ALB
22myocardial infarction9.9
23pseudohypoaldosteronism9.9
24hyperekplexia9.9
25hypertensive hypokalemia familial9.9
26galactosemia9.8INS, ALB
27diabetic retinopathy9.8AGT, ALB, INS
28congenital heart disease9.8INS, ALB, AGT
29essential hypertension9.8AGT, ALB, INS
30diabetic nephropathy9.8INS, ALB, AGT
31proteinuria9.8AGT, ALB, INS
32type 1 diabetes mellitus9.8AGT, ALB, INS
33hyperglycemia9.8AGT, ALB, INS
34chronic kidney failure9.8INS, ALB, AGT
35type 2 diabetes mellitus9.8AGT, ALB, INS
36insulin resistance9.8INS, ALB, AGT
37diabetes mellitus9.8AGT, ALB, INS
38atherosclerosis9.8INS, ALB, AGT
39cystic fibrosis9.8ALB, INS
40breast cancer9.6AGT, ALB, INS

Graphical network of the top 20 diseases related to Familial Hypertension:



Diseases related to familial hypertension

Symptoms for Familial Hypertension

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Drugs & Therapeutics for Familial Hypertension

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Drug clinical trials:

Search ClinicalTrials for Familial Hypertension

Search NIH Clinical Center for Familial Hypertension

Genetic Tests for Familial Hypertension

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Anatomical Context for Familial Hypertension

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MalaCards organs/tissues related to Familial Hypertension:

32
Kidney

Animal Models for Familial Hypertension or affiliated genes

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MGI Mouse Phenotypes related to Familial Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5AGT, ALB, INS
2MP:00053708.4AGT, ALB, INS
3MP:00053678.2AGT, ALB, INS

Publications for Familial Hypertension

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Articles related to Familial Hypertension:

(show all 21)
idTitleAuthorsYear
1
The polymorphism of angiotensin-receptor gene A1166C in familial hypertension and its distribution in the Han Yellow race of China. (24145933)
2013
2
An inducible transgenic mouse model for familial hypertension with hyperkalaemia (Gordon's syndrome or pseudohypoaldosteronism type II). (23336180)
2013
3
Renal FMD may not confer a familial hypertensive risk nor is it caused by ACTA2 mutations. (21553326)
2011
4
The metabolic syndrome and risk of myocardial infarction in familial hypertension (hypertension heredity in MalmAP evaluation study). (19050451)
2009
5
The effects of exercise on haemodynamic function in relation to the familial hypertension risk model. (16496017)
2006
6
Spironolactone responsive familial hypertension. A potentially high prevalence of mineralocorticoid disease in Oman. (12682699)
2003
7
Influence of familial hypertension on blood pressure, serum cholesterol, high density lipoprotein cholesterol during second and third decade of life in Punjabi population. (15255633)
2003
8
High urinary excretion of uric acid combined with high excretion of calcium links kidney stone disease to familial hypertension. (11812875)
2002
9
Effect of familial hypertension on glomerular hemodynamics and tubulo-glomerular feedback after uninephrectomy. (11243302)
2001
10
Abnormalities in insulin sensitivity, vascular resistance and erythrocyte cation transport are independent genetic traits in familial hypertension. (10451037)
1999
11
Familial hypertension, insulin, sympathetic activity, and blood pressure elevation. (9674644)
1998
12
Association of M235T variant of the angiotensinogen gene with familial hypertension of early onset. (7478115)
1995
13
Familial hypertension in Morgagni's De Sedibus et Causis Morborum per Anatomen Indagatis. (7847481)
1994
14
Familial hypertension and albuminuria in normotensive type I diabetic patients. (8282370)
1994
15
Cross-sectional analysis of Met235-->Thr variant of angiotensinogen gene in severe, familial hypertension. (8267622)
1993
16
Influence of familial hypertension of the donor on the blood pressure and antihypertensive therapy of kidney graft recipients. (7050749)
1982
17
Influence of familial hypertension on blood pressure during adolescence. (6975038)
1981
18
Familial hypertension and hormonal profile, renal haemodynamics and body fluids of young normotensive subjects. (282088)
1978
19
Familial hypertension. (1185030)
1975
20
Chronic hypertension following pre-eclamptic toxaemia: the influence of familial hypertension on its causation. (13564280)
1958
21
Chronic hypertension following pre-eclamptic toxaemia; the influence of familial hypertension on its causation. (13367916)
1956

Variations for Familial Hypertension

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Expression for genes affiliated with Familial Hypertension

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Expression patterns in normal tissues for genes affiliated with Familial Hypertension

Search GEO for disease gene expression data for Familial Hypertension.

Pathways for genes affiliated with Familial Hypertension

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Pathways related to Familial Hypertension according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3AGT, INS
2
Show member pathways
9.3AGT, INS
39.3AGT, INS
4
Show member pathways
thioredoxin pathway37
9.1INS, ALB
59.1ALB, INS
69.1ALB, INS
7
Show member pathways
8.5AGT, ALB, INS

Compounds for genes affiliated with Familial Hypertension

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Compounds related to Familial Hypertension according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1olmesartan44 28 1111.8AGT, INS
2c-peptide449.7INS, AGT
3acth449.6AGT, INS
4nn304449.6ALB, INS
5epinephrine44 24 1111.6AGT, INS
6fructosamine44 2410.6ALB, INS
7repaglinide50 44 1111.6ALB, INS
8ramipril44 1110.6INS, ALB
9nateglinide44 50 1111.5ALB, INS
10gliclazide44 50 1111.5ALB, INS
11norepinephrine44 24 1111.5AGT, INS
12rapamycin449.5AGT, INS
13rosuvastatin44 50 28 1112.5ALB, INS
14olanzapine44 50 28 24 1113.5ALB, INS
15ly294002449.5INS, AGT
16myristic acid44 24 1111.5INS, ALB
17inulin449.5ALB, AGT
18uric acid44 2410.5ALB, INS
19lisinopril44 50 24 1112.5AGT, ALB
20palmitate449.5INS, ALB
21wortmannin449.4AGT, INS
22valsartan44 61 28 1112.4ALB, AGT
23perindopril44 50 1111.4AGT, ALB
24irbesartan44 28 50 1112.4AGT, ALB
25candesartan44 50 28 1112.4AGT, ALB
26rosiglitazone28 44 50 24 1113.4ALB, INS
27hydrochlorothiazide44 28 50 24 1113.4AGT, ALB
28amlodipine44 50 24 1112.4ALB, AGT
29enalapril44 50 1111.4ALB, AGT
30thyroxine44 2410.4ALB, INS
31tacrolimus44 50 1111.4INS, ALB
32captopril44 61 50 28 1113.4AGT, ALB
33losartan44 50 28 1112.4AGT, ALB
34homocysteine44 2410.3AGT, ALB
35indomethacin44 28 61 1112.3ALB, AGT
36lactate449.1ALB, INS
37potassium44 24 1111.1AGT, ALB
38estradiol44 24 1111.0ALB, AGT
39telmisartan44 28 1111.0AGT, ALB, INS
40fibrinogen448.9INS, ALB, AGT
41arachidonic acid44 28 24 1111.9AGT, ALB
42creatinine448.9INS, ALB, AGT
43cholesterol44 28 24 1111.9INS, ALB, AGT
44glucose448.8AGT, ALB, INS
45fatty acid448.8ALB, INS
46lipid448.8INS, ALB, AGT

GO Terms for genes affiliated with Familial Hypertension

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Cellular components related to Familial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725628.7AGT, ALB
2extracellular regionGO:0055768.5AGT, ALB, INS
3extracellular spaceGO:0056158.4AGT, ALB, INS

Biological processes related to Familial Hypertension according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cellular protein metabolic processGO:0322709.5AGT, INS
2positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.5AGT, INS
3positive regulation of MAPK cascadeGO:0434109.4AGT, INS
4positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4AGT, INS
5positive regulation of NF-kappaB transcription factor activityGO:0510929.3INS, AGT
6G-protein coupled receptor signaling pathwayGO:0071869.3AGT, INS
7cell-cell signalingGO:0072679.0AGT, INS
8small molecule metabolic processGO:0442818.4AGT, ALB, INS

Molecular functions related to Familial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.3AGT, INS

Products for genes affiliated with Familial Hypertension

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  • Antibodies
  • Proteins
  • Lysates

Sources for Familial Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet