FIPA
MCID: FML168
MIFTS: 34

Familial Isolated Pituitary Adenoma (FIPA) malady

Genetic diseases, Rare diseases, Gastrointestinal diseases categories
Download this MalaCard

Summaries for Familial Isolated Pituitary Adenoma

About this section
Sources:
21Genetics Home Reference, 33MalaCards
See all sources

Fully expand this MalaCard
Genetics Home Reference:21 Familial isolated pituitary adenoma (FIPA) is an inherited condition characterized by development of a noncancerous tumor in the pituitary gland (called a pituitary adenoma). The pituitary gland, which is found at the base of the brain, produces hormones that control many important body functions.

MalaCards: Familial Isolated Pituitary Adenoma, also known as FIPA, is related to pituitary adenoma and adenoma. An important gene associated with Familial Isolated Pituitary Adenoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are AHR Pathway and TSH signaling pathway. The compounds octreotide and forskolin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, and related mouse phenotypes are adipose tissue and cardiovascular system.

Aliases & Classifications for Familial Isolated Pituitary Adenoma

About this section
Sources:
62UMLS, 43NIH Rare Diseases, 21Genetics Home Reference
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

familial isolated pituitary adenoma 43 21
fipa 43 21
familial isolated pituitary adenoma syndrome 43
pituitary adenoma, familial isolated 62
multiple gastrointestinal atresias 62


Related Diseases for Familial Isolated Pituitary Adenoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Familial Isolated Pituitary Adenoma:



Diseases related to familial isolated pituitary adenoma

Symptoms for Familial Isolated Pituitary Adenoma

About this section

Drugs & Therapeutics for Familial Isolated Pituitary Adenoma

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Familial Isolated Pituitary Adenoma

Search NIH Clinical Center for Familial Isolated Pituitary Adenoma

Genetic Tests for Familial Isolated Pituitary Adenoma

About this section

Anatomical Context for Familial Isolated Pituitary Adenoma

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Familial Isolated Pituitary Adenoma:

33
Pituitary

Animal Models for Familial Isolated Pituitary Adenoma or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Familial Isolated Pituitary Adenoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8GNAS, PRKAR1A, CDKN1B
2MP:00053858.5CDKN1B, PRKAR1A, GNAS, AIP
3MP:00020068.4AIP, CDKN1B, PRKAR1A, SF1
4MP:00053788.1AIP, GNAS, PRKAR1A, SSTR5, CDKN1B
5MP:00053797.4SF1, AIP, GNAS, PRKAR1A, SSTR5, CDKN1B
6MP:00053767.4AIP, PRKAR1A, SSTR5, GNAS, CDKN1B, SF1
7MP:00107687.4PRKAR1A, GNAS, SF1, AIP, CDKN1B

Publications for Familial Isolated Pituitary Adenoma

About this section
Sources:
52PubMed
See all sources

Articles related to Familial Isolated Pituitary Adenoma:

(show all 15)
idTitleAuthorsYear
1
Clinical experience in the screening and management of a large kindred with familial isolated pituitary adenoma due to an aryl hydrocarbon receptor interacting protein (AIP) mutation. (24423289)
2013
2
Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene. (23371967)
2013
3
Familial isolated pituitary adenoma caused by a Aip gene mutation not described before in a family context. (24078436)
2013
4
Cyclin-dependent kinase inhibitor 1B (CDKN1B) gene variants in AIP mutation-negative familial isolated pituitary adenoma kindreds. (22291433)
2012
5
Genetic analysis in a patient presenting with meningioma and familial isolated pituitary adenoma (FIPA) reveals selective involvement of the R81X mutation of the AIP gene in the pathogenesis of the pituitary tumor. (22527616)
2012
6
Familial isolated pituitary adenoma: evidence for genetic heterogeneity. (20616498)
2010
7
Familial isolated pituitary adenomas experience at a single center: clinical importance of AIP mutation screening. (21340155)
2010
8
The R304X mutation of the aryl hydrocarbon receptor interacting protein gene in familial isolated pituitary adenomas: Mutational hot-spot or founder effect? (20354355)
2010
9
Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families. (20506337)
2010
10
Genetic, molecular and clinical features of familial isolated pituitary adenomas. (19407507)
2009
11
Update on familial pituitary tumors: from multiple endocrine neoplasia type 1 to familial isolated pituitary adenoma. (19153518)
2009
12
Silent familial isolated pituitary adenomas: histopathological and clinical case report. (18317953)
2008
13
The clinical, pathological, and genetic features of familial isolated pituitary adenomas. (17893250)
2007
14
Aryl hydrocarbon receptor-interacting protein gene mutations in familial isolated pituitary adenomas: analysis in 73 families. (17244780)
2007
15
AIP-Related Familial Isolated Pituitary Adenomas (22720333)
1993

Variations for Familial Isolated Pituitary Adenoma

About this section

Expression for genes affiliated with Familial Isolated Pituitary Adenoma

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Familial Isolated Pituitary Adenoma

Search GEO for disease gene expression data for Familial Isolated Pituitary Adenoma.

Pathways for genes affiliated with Familial Isolated Pituitary Adenoma

About this section
Sources:
50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters
See all sources

Pathways related to Familial Isolated Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
AhR pathway38
9.6CDKN1B, AIP
29.4CDKN1B, GNAS
3
Show member pathways
9.3GNAS, PRKAR1A
4
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
9.3GNAS, PRKAR1A
5
Show member pathways
9.3PRKAR1A, GNAS
6
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.3GNAS, PRKAR1A
7
Show member pathways
Signal transduction cAMP signaling60
9.3GNAS, PRKAR1A
8
Show member pathways
9.3GNAS, PRKAR1A
99.3PRKAR1A, GNAS
109.3GNAS, PRKAR1A
11
Show member pathways
9.3PRKAR1A, GNAS
12
Show member pathways
Development A2B receptor action via G protein alpha s60
9.3GNAS, PRKAR1A
139.3GNAS, PRKAR1A
14
Show member pathways
8.9GNAS, PRKAR1A, CDKN1B
15
Show member pathways
8.5CDKN1B, GNAS, SSTR5, PRKAR1A

Compounds for genes affiliated with Familial Isolated Pituitary Adenoma

About this section
Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB
See all sources

Compounds related to Familial Isolated Pituitary Adenoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1octreotide45 61 29 1112.1SSTR5, GNAS
2forskolin45 51 1110.9PRKAR1A, GNAS, CDKN1B
3thymidine45 249.9GNAS, SSTR5, CDKN1B
4arginine458.9GNAS, PRKAR1A, CDKN1B
5glutamine458.6CDKN1B, GNAS, SF1
6cyclic amp45 249.5PRKAR1A, CDKN1B, CNC2, GNAS

GO Terms for genes affiliated with Familial Isolated Pituitary Adenoma

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Familial Isolated Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1energy reserve metabolic processGO:0061129.3PRKAR1A, GNAS
2cellular response to glucagon stimulusGO:0713779.2PRKAR1A, GNAS
3water transportGO:0068339.0PRKAR1A, GNAS
4regulation of insulin secretionGO:0507968.9SSTR5, PRKAR1A, GNAS

Products for genes affiliated with Familial Isolated Pituitary Adenoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Familial Isolated Pituitary Adenoma

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet