FIPA
MCID: FML168
MIFTS: 27

Familial Isolated Pituitary Adenoma (FIPA) malady

Gastrointestinal diseases, Genetic diseases categories

Summaries for Familial Isolated Pituitary Adenoma

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21Genetics Home Reference, 32MalaCards
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Genetics Home Reference:21 Familial isolated pituitary adenoma (FIPA) is an inherited condition characterized by development of a noncancerous tumor in the pituitary gland (called a pituitary adenoma). The pituitary gland, which is found at the base of the brain, produces hormones that control many important body functions.

MalaCards: Familial Isolated Pituitary Adenoma, also known as FIPA, is related to pituitary adenoma and adenoma. An important gene associated with Familial Isolated Pituitary Adenoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are AhR pathway and Development A2B receptor- action via G-protein alpha s. The compounds octreotide and forskolin have been mentioned in the context of this disorder. Affiliated tissues include pituitary and brain, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Aliases & Classifications for Familial Isolated Pituitary Adenoma

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60UMLS, 42NIH Rare Diseases, 21Genetics Home Reference
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

familial isolated pituitary adenoma 42 21
fipa 42 21
familial isolated pituitary adenoma syndrome 42
pituitary adenoma, familial isolated 60
multiple gastrointestinal atresias 60


Related Diseases for Familial Isolated Pituitary Adenoma

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17GeneCards, 18GeneDecks
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Diseases in the Familial Isolated Pituitary Adenoma family:

Aip-Related Familial Isolated Pituitary Adenomas

Diseases related to Familial Isolated Pituitary Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 34)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary adenoma31.1CDKN1B, CNC, AIP, SSTR5, PRKAR1A, GNAS
2adenoma31.1GNAS, PRKAR1A, SSTR5, AIP, CNC, CDKN1B
3prolactinoma30.5AIP, SSTR5, PRKAR1A, GNAS
4aip-related familial isolated pituitary adenomas10.5
5multiple intestinal atresia10.2
6growth hormone secreting pituitary adenoma10.2
7familial meningioma10.2
8meningioma10.2
9imperforate anus10.1
10obesity10.0GNAS
11graves' disease10.0GNAS
12hypoparathyroidism10.0PRKAR1A
13melanoma10.0CDKN1B
14osteomalacia10.0GNAS
15ovarian cyst10.0CNC, GNAS
16adrenal gland hyperfunction10.0CNC, PRKAR1A
17acrodysostosis10.0GNAS, PRKAR1A
18mccune albright syndrome10.0PRKAR1A, GNAS
19hyperparathyroidism10.0CDKN1B, PRKAR1A
20neurilemmoma10.0PRKAR1A, CNC
21peutz-jeghers syndrome10.0CNC, PRKAR1A
22pheochromocytoma10.0SSTR5, GNAS
23adrenal adenoma10.0GNAS, PRKAR1A, CNC
24cushing's syndrome10.0CNC, PRKAR1A, GNAS
25thyroid adenoma10.0GNAS, PRKAR1A, CNC
26thyroid cancer10.0CDKN1B, GNAS
27thyroid medullary carcinoma10.0SSTR5, PRKAR1A
28parathyroid adenoma10.0GNAS, PRKAR1A, CDKN1B
29papillary carcinoma10.0CDKN1B, GNAS
30carney complex10.0CDKN1B, AIP, PRKAR1A, GNAS
31multiple endocrine neoplasia10.0CDKN1B, CNC, PRKAR1A, GNAS
32wermer syndrome10.0SF1, GNAS, PRKAR1A, CNC, CDKN1B
33acromegaly10.0GNAS, PRKAR1A, SSTR5, AIP, CNC
34pituitary tumors9.9GNAS, PRKAR1A, SSTR5, AIP, CNC, CDKN1B

Graphical network of the top 20 diseases related to Familial Isolated Pituitary Adenoma:



Diseases related to familial isolated pituitary adenoma

Clinical Features for Familial Isolated Pituitary Adenoma

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Drugs & Therapeutics for Familial Isolated Pituitary Adenoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Familial Isolated Pituitary Adenoma

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Anatomical Context for Familial Isolated Pituitary Adenoma

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32MalaCards
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MalaCards organs/tissues related to Familial Isolated Pituitary Adenoma:

32
Pituitary, Brain

Animal Models for Familial Isolated Pituitary Adenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Familial Isolated Pituitary Adenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7CDKN1B, AIP, PRKAR1A, SF1
2MP:00053797.5CDKN1B, AIP, SSTR5, PRKAR1A, GNAS, SF1
3MP:00053767.3SF1, GNAS, PRKAR1A, SSTR5, AIP, CDKN1B

Publications for Familial Isolated Pituitary Adenoma

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Genetic Variations for Familial Isolated Pituitary Adenoma

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Expression for genes affiliated with Familial Isolated Pituitary Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Isolated Pituitary Adenoma

Search GEO for disease gene expression data for Familial Isolated Pituitary Adenoma.

Pathways for genes affiliated with Familial Isolated Pituitary Adenoma

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 53Reactome
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Compounds for genes affiliated with Familial Isolated Pituitary Adenoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Familial Isolated Pituitary Adenoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1octreotide44 59 28 1112.0SSTR5, GNAS
2forskolin44 49 1111.0CDKN1B, PRKAR1A, GNAS
3thymidine44 249.9CDKN1B, SSTR5, GNAS
4glutamine448.8SF1, GNAS, CDKN1B
5cyclic amp44 249.2CDKN1B, CNC, PRKAR1A, GNAS

GO Terms for genes affiliated with Familial Isolated Pituitary Adenoma

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16Gene Ontology
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Biological processes related to Familial Isolated Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1water transportGO:0068339.4PRKAR1A, GNAS
2cellular response to glucagon stimulusGO:0713779.1PRKAR1A, GNAS
3regulation of insulin secretionGO:0507968.8SSTR5, PRKAR1A, GNAS

Products for genes affiliated with Familial Isolated Pituitary Adenoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Familial Isolated Pituitary Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet