Familial Mediterranean Fever malady

MedlinePlus: A fever is a body temperature that is higher than normal. it is not an illness. it is part of your body's defense against infection. most bacteria and viruses that cause infections do well at the body's normal temperature (98.6 f). a slight fever can make it harder for them to survive. fever also activates your body's immune system. infections cause most fevers. there can be many other causes, including medicines heat exhaustion cancers autoimmune diseases treatment depends on the cause of your fever. your health care provider may recommend using over-the-counter medicines such as acetaminophen or ibuprofen to lower a very high fever. adults can also take aspirin, but children with fevers should not take aspirin. it is also important to drink enough liquids to prevent dehydration.²³

MalaCards: Familial Mediterranean Fever, also known as recurrent polyserositis, is related to periodic fever, familial, autosomal dominant and brucellosis. An important gene associated with Familial Mediterranean Fever is MEFV (Mediterranean fever), and among its related pathways are Immune response Role of DAP12 receptors in NK cells and Bacterial infections in CF airways. The drugs colchicine and streptomycin and the compounds glucose and ivig have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and monocytes, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Genetics Home Reference: Familial Mediterranean fever is an inherited condition characterized by recurrent episodes of painful inflammation in the abdomen, chest, or joints. These episodes are often accompanied by fever and sometimes a rash. The first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. Typically, episodes last 12 to 72 hours and can vary in severity. The length of time between attacks is also variable. Without treatment to help prevent attacks and complications, a buildup of certain protein deposits (amyloidosis) in the body's organs and tissues may occur, which can lead to kidney failure.¹⁷

NIH Rare Diseases: Familial Mediterranean fever (FMF) is an inherited condition characterized by episodes of painful inflammation of the abdominal lining (peritonitis),  lining surrounding the lungs (pleurisy), and joints (arthralgia and occasionally arthritis). These episodes are often accompanied by fever and sometimes a characteristic ankle rash. The first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. Between attacks, people often do not have any symptoms. Without treatment, FMF can lead to kidney failure due to a buildup of certain protein deposits (amyloidosis). FMF is usually inherited in an autosomal recessive fashion and is caused by mutations in the MEFV gene.³⁰

Wikipedia: Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder. FMF is an autoinflammatory...⁴⁴ more...

GeneReviews summary for fmf

Aliases & Descriptions:

familial mediterranean fever 6 7 15 30 17 8 32 43 recurrent polyserositis 44 15 30 16 17 benign paroxysmal peritonitis 6 44 30 17 mediterranean fever, familial 44 16 17 periodic peritonitis 44 30 17 periodic disease 44 30 17 fever 44 17 23 hereditary periodic fever syndromes 17 32 familial paroxysmal polyserositis 44 30 wolff periodic disease 44 17

fmf 44 17 familial mediterranean fever (disorder) 6 hereditary autoinflammatory diseases 43 hereditary periodic fever syndrome 44 siegal-cattan-mamou disease 17 reimann periodic disease 17 periodic fever 30 brucellosis 43 mef 17

Disease types for familial mediterranean fever family:

familial mediterranean fever type 1	familial mediterranean fever type 2
familial mediterranean fever, ar	familial mediterranean fever, ad

Diseases related to familial mediterranean fever by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1176)

id	Related Disease	Score	Top Affiliating Genes
1	periodic fever, familial, autosomal dominant	34.5	MVK, MEFV, TNF, TNFRSF1A
2	brucellosis	33.7	SELL, SAA1, CD14, MICA, MEFV, IL10
3	hyper-igd syndrome	32.9	MVK, SAA1, IL1RN, TNF, TNFRSF1A, CRP
4	arthritis	32.7	SELL, IL1B, IL6, IL8, TNF, TNFRSF1A
5	paratyphoid fever	32.5	IL1B, IL1R1, IFNG, CASP1, TNF, TNFRSF1A
6	amyloidosis	32.1	SERPINC1, SAA1, SAA2, SAA4, B2M, CD14
7	typhoid fever	32.1	IL1B, IL1R1, IFNG, F2, CASP1, HLA-DQB1
8	colchicine resistance	32.1	MEFV, IL1R1, ABCB1
9	hemorrhagic fever with renal syndrome	31.9	B2M, ITGAM, IL10, IL6, IFNG, HLA-B
10	spotted fever	31.7	IL10, IFNG, F2, TNF, THBD
11	rheumatoid arthritis	31.6	IL1R1, IL1RN, HLA-DRB1, TNFRSF1A, CRP
12	mevalonic aciduria	31.4	MVK, IL1RN, IDS, CARD17, NLRP3
13	polyarteritis nodosa	31.3	MEFV, IL6, IL8, APOH, CRP
14	rheumatic fever	31.2	IL1B, IL2RA, IL6, IL8, ALB, HP
15	crimean-congo hemorrhagic fever	31.1	VEGFA, IL6, F2, TNF, RNPC3
16	ankylosing spondylitis	30.9	IL1R1, IL1RAPL2, IL1RN, HP, HLA-B, TNF
17	african tick-bite fever	30.7	IL10, CCL3, IFNG
18	coccidioidomycosis	30.5	IL10, IL12A, IFNG, TLR4
19	septic arthritis	30.3	MEFV, IL1B, IFNG, TNF, CRP, TLR2
20	crohn's disease	30.2	IL10, IL18, IL1B, IL1R1, IL1RAPL2, IL1RN
21	periodic fever	30.1	MVK, SAA1, MEFV, IL1B, IL1R1, IL1RAPL2
22	hemorrhagic fever	29.9	SERPINC1, VEGFA, B2M, ITGAM, IL10, IL1R1
23	familial cold autoinflammatory syndrome	29.8	MEFV, IL1B, IL1R1, CASP1, TNFRSF1A, NLRP3
24	q fever	29.5	SELL, CD14, IL10, IL1B, IL1R1, IL1RAPL2
25	hernia	29.4	MMP1, IL1RAPL2, F2, ALB, TNF, CRP
26	pericarditis	29.1	MEFV, IL1B, IL6, IL8, ALB, TNF
27	behcet's disease	29.0	KIR2DL1, KIR3DL1, SELL, MEFV, IL18, IL2RA
28	multiple sclerosis	29.0	CD14, MICA, IL12A, IL1B, IL1RN, IL2RA
29	wells syndrome	29.0	MEFV, IL1B, IL1R1, IL1RAPL2, IL8, CASP1
30	muckle-wells syndrome	29.0	MEFV, IL1B, IL1R1, IL1RAPL2, IL8, CASP1
31	schnitzler syndrome	28.8	IL18, IL1R1, IL1RAPL2, IL1RN, TNF, PYCARD
32	glomerulopathy	28.8	SELP, LEP, MEFV, IL2RA, ALB, ACE
33	hepatitis	28.7	SELP, FAS, F2, ALB, HLA-A, HLA-DRB1
34	aphthous stomatitis	28.7	MVK, MEFV, IL10, IL12A, IL1B, IL1RN
35	stomatitis	28.5	MICA, MEFV, IL10, IL12A, IL1B, IL1RN
36	dengue hemorrhagic fever	28.5	SERPINC1, VEGFA, IL10, IL1R1, IL6, IL8
37	sepsis	28.5	CD14, IL10, TNF
38	dengue shock syndrome	28.4	IL1B, IL1RAPL2, IL1RN, IL6, HLA-A, HLA-DRB1
39	hemolytic anemia	28.3	APOH, HP, TF, TFRC, ADA
40	chronic infantile neurological cutaneous articular syndrome	28.2	MVK, MEFV, IL18, IL1B, IL1R1, IL1RAPL2
41	adult-onset still's disease	28.2	IL18, IL1R1, IL1RAPL2, IL6, CRP
42	nephropathia epidemica	28.2	IL1B, IL1RN, IL6, HLA-B, HLA-DRB1, TNF
43	lyme disease	28.2	IL1B, IL6, CCL3, IFNG, HLA-DQB1, HLA-DRB1
44	infectious mononucleosis	28.1	B2M, IL10, IL6, APOH, IFNG, HP
45	listeriosis	28.1	KIR2DS4, IL6, IFNG, TNF
46	endocarditis	28.0	SERPINC1, CD14, APOA1, APOH, F2, ALB
47	peritoneal carcinoma	28.0	IL10, IL6, IL8, IFNG
48	hemophagocytic lymphohistiocytosis	28.0	IL18, IL2RA, IL8, FAS, IFNG, F2
49	bronchitis	27.8	SELL, LEP, SAA1, CASP1, NOD2, TF
50	hypertrophic cardiomyopathy	27.6	SELP, IL6, ALB, HLA-B, TNF, ACE

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 colchcine, colchicine, rifampin, streptomycin, streptomycin sulfate

Genetic tests related to familial mediterranean fever:

id	Genetic test	Affiliating Genes
1	Familial Mediterranean Fever clinical/research	MEFV

MalaCards organs/tissues related to familial mediterranean fever:

²²

MGI Mouse Phenotypes related to familial mediterranean fever:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.2	GSN, MEFV, HLA-DQB1, PYCARD, NOD2, NLRC5
2	renal/urinary system phenotype	MP:0005367	10.1	ADM, CXCR2, ABCC6, NLRP3, CTSB, GPX3
3	respiratory system phenotype	MP:0005388	10.1	ADA, IL12A, GSN, CD14, SELP, SELL
4	endocrine/exocrine gland phenotype	MP:0005379	9.8	DBH, TLR2, PYCARD, IFNG, GSN, ATN1
5	integument phenotype	MP:0010771	8.9	TNFRSF1A, CTSB, NLRP3, ABCC6, TLR2, TLR4
6	nervous system phenotype	MP:0003631	8.6	CASP1, HLA-DQB1, TNFRSF1A, TLR2, TLR4, THBD
7	liver/biliary system phenotype	MP:0005370	8.4	SERPINC1, VEGFA, MEFV, IL1R1, IL6, APOA1
8	immune system phenotype	MP:0005387	8.2	TLR4, TFRC, PSTPIP1, C5AR1, ADM, NLRC5
9	skeleton phenotype	MP:0005390	7.9	IDS, TNFRSF11B, TNFRSF1A, PLAT, NOD2, C5AR1
10	digestive/alimentary phenotype	MP:0005381	7.6	PYCARD, CTSB, PLAT, NOD2, TLR2, TFRC
11	reproductive system phenotype	MP:0005389	7.5	TNF, TNFRSF1A, NLRP3, TLR4, TIMP1, CXCR2
12	tumorigenesis	MP:0002006	7.4	HP, TNF, TNFRSF1A, CTSB, ACE, TLR2
13	growth/size phenotype	MP:0005378	7.2	PYCARD, CTSB, PLAT, NLRP3, ACE, TLR4
14	vision/eye phenotype	MP:0005391	6.8	IFNG, TNF, TNFRSF1A, PLAT, ABCC6, TLR4
15	behavior/neurological phenotype	MP:0005386	5.7	CTSB, TNFRSF1A, TNF, HLA-DQB1, IDS, PLAT
16	mortality/aging	MP:0010768	4.7	ABCB1, NLRP3, NOD2, PLAT, CTSB, TNFRSF1A
17	cardiovascular system phenotype	MP:0005385	4.4	SERPINE1, VEGFA, LMX1B, LEP, B2M, GSN
18	cellular phenotype	MP:0005384	4.2	CTSB, TNFRSF1A, TNFRSF11B, TNF, HLA-DQB1, HP
19	homeostasis/metabolism phenotype	MP:0005376	4.0	SELL, FAS, CCL3, GPX3, F2, ALB

Articles related to familial mediterranean fever:

(show top 50)    (show all 259)

id	Title	Authors	Year	Affiliating Genes
1	Familial Mediterranean fever with a single MEFV mutat ion: can a deletion resulting in I+-thalassemia be the cause? (21179105)	Aslan D.	2011	MEFV
2	Familial Mediterranean fever and seronegative arthrit is. (21695514)	Akkoc N.... Gul A.	2011	MEFV
3	Common Familial Mediterranean Fever gene mutations in a Turkish cohort. (21153919)	Dundar M.... Baskol M.	2011	MEFV
4	Investigation of C5a receptor gene 450 C/T polymorphi sm in Turkish patients with familial Mediterranean fever. (19657723)	Erken E.... Ozer H.T.	2010	MEFV, C5AR1
5	Demographic, clinical and mutational characteristics of Turkish familial Mediterranean fever patients: results of a single center in Central Anatolia. (19641922)	Ureten K.... OztA1rk M.A.	2010	MEFV
6	The Familial Mediterranean Fever Gene as a Modifier o f Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenopathy Syndrome. (20828792)	Berkun Y.... Padeh S.	2010	MEFV
7	Common MEFV mutation analysis in 36 Iranian patients with familial Mediterranean fever: clinical and demographic significance. (20549290)	Bidari A.... Ghalehbaghi B.	2010	MEFV
8	Unresponsiveness to colchicine therapy in patients wi th familial Mediterranean fever homozygous for the M694V mutation. (20008920)	Soylemezoglu O.... Buyan N.	2010	MEFV
9	Characterization of new mutations in the 5'-flanking region of the familial Mediterranean fever gene. (19262573)	Notarnicola C.... Touitou I.	2009	MEFV
10	Current perspectives on familial Mediterranean fever. (19339884)	Guz G.... Ozturk M.A.	2009	MEFV, SAA1
11	Clinical features of familial Mediterranean fever: an Italian overview. (19530512)	Manna R.... Gasbarrini G.	2009	MEFV
12	Familial Mediterranean Fever: a review for clinical management. (19091621)	Fonnesu C.... Manna R.	2009	MEFV
13	Familial Mediterranean fever as representative autoi nflammatory disease (19489440)	Yamazaki K.... Agematsu K.	2009	MEFV
14	Presentation of familial Mediterranean fever in a het erozygous MEFV mutation triggered by immunosuppressive therapy for myelodysplas tic syndrome. (19466506)	Sasaki K.... Mitani K.	2009	MEFV
15	Familial Mediterranean Fever in Armenian population. (18403822)	Sarkisian T.... Egiazaryan A.	2008	MEFV
16	The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment. (18577712)	Chae J.J.... Kastner D.L.	2008	CASP1, MEFV
17	Familial Mediterranean fever gene mutations in the Southeastern region of Turkey and their phenotypical features. (18266121)	Pasa S.... Ayyildiz O.	2008	MEFV
18	The Effect of Plasminogen Activator Inhibitor-1 -675 4G/5G Polymorphism on Familial Mediterranean Fever (FMF) Disease. (19033264)	Ozel Demiralp D.F.... Akar N.	2008	SERPINE1, MEFV
19	Multiple visceral hematomas in a child with familial Mediterranean fever: polyarteritis nodosa. (18183427)	Baysun S.... Oner A.	2008	MEFV
20	Analysis of familial Mediterranean fever gene mutations in 202 patients with familial Mediterranean fever. (18662100)	Solak M.... Arikan E.	2008	MEFV
21	The population genetics of familial mediterranean fever: a meta-analysis study. (18691160)	Papadopoulos V.P.... Ritis K.	2008	MEFV
22	The evaluation of carotid intima-media thickness in children with familial Mediterranean fever. (17926078)	Peru H.... Oran B.	2008	CRP
23	Evaluation of intima media thickness of the common and internal carotid arteries with inflammatory markers in familial Mediterranean fever as possible predictors for atherosclerosis. (18500463)	Bilginer Y.... Bakkaloglu A.	2008	SAA1, SAA4
24	Genetics and new treatment modalities for familial Mediterranean fever. (17911435)	Bhat A.... Gershwin M.E.	2007	TNF, MEFV, IL1RAPL2
25	Vasculitis in siblings with familial Mediterranean fever: a report of three cases and review of the literature. (16721494)	Balbir-Gurman A.... Braun-Moscovici Y.	2007	MEFV
26	Is MEFV P706 polymorphism important in familial Mediterranean fever patients? (16523438)	Akar N.... Ekim M.	2006	MEFV
27	Adrenomedullin and total nitrite levels in children with familial Mediterranean fever. (16712551)	Balat A.... SahinAPz S.	2006	ADM
28	Arg753Gln TLR-2 polymorphism in familial mediterranean fever: linking the environment to the phenotype in a monogenic inflammatory disease. (17013994)	Ozen S.... Yilmaz E.	2006	TLR2
29	Serum amyloid A1 -13 T/C alleles in Turkish familial Mediterranean fever patients with and without amyloidosis. (16874691)	Akar N.... Tekin M.	2006	SAA1
30	Familial Mediterranean fever (FMF) in Lebanon and Jordan: a population genetics study and report of three novel mutations. (16378925)	Medlej-Hashim M.... Megarbane A.	2005	MEFV
31	MEFV mutations in familial Mediterranean fever: association of M694V homozygosity with arthritis. (14727057)	Olgun A.... Kutluay T.	2005	MEFV
32	Comparison of amplification refractory mutation system and polymerase chain reaction-restriction fragment length polymorphism techniques used for the investigation of MEFV gene exon 10 point mutations in familial Mediterranean fever patients living in Cukurova region (Turkey). (16225401)	Gunesacar R.... Ozer H.T.	2005	MEFV
33	The spectrum of familial Mediterranean fever gene mutations in Arabs: report of a large series. (15942916)	Majeed H.A.... Najib D.	2005	MEFV
34	Lipopolysaccharide-induced expression of multiple alternatively spliced MEFV transcripts in human synovial fibroblasts: a prominent splice isoform lacks the C-terminal domain that is highly mutated in familial Mediterranean fever. (15529356)	Diaz A.... Gumucio D.L.	2004	MEFV
35	Prevalence and significance of mutations in the familial Mediterranean fever gene in Henoch-Schonlein purpura. (14615741)	Gershoni-Baruch R.... Brik R.	2003	MEFV
36	Th1 polarization in familial Mediterranean fever. (12966607)	Aypar E.... Bakkaloglu A.	2003	MEFV
37	Common mutations in the familial Mediterranean fever gene associate with rapid progression to disability in non-Ashkenazi Jewish multiple sclerosis patients. (12700594)	Shinar Y.... Achiron A.	2003	MEFV
38	A Japanese case of familial Mediterranean fever with family history demonstrating a mutation in MEFV. (12924509)	Yoshida K.... Hishida A.	2003	MEFV
39	Familial Mediterranean fever with amyloidosis associated with novel exon 2 mutation (S1791) of the MEFV gene. (14636645)	Timmann C.... Horstmann R.D.	2003	MEFV
40	Familial Mediterranean fever associated pyrin mutations in Greece. (12695165)	Konstantopoulos K.... Moutsopoulos H.M.	2003	MEFV
41	The significance of paired MEFV mutations in individuals without symptoms of familial Mediterranean fever. (12461684)	Tunca M.... Booth D.R.	2002	MEFV
42	Reduced MEFV messenger RNA expression in patients with familial Mediterranean fever. (12384939)	Notarnicola C.... Touitou I.	2002	MEFV
43	Prevalence and significance of the familial Mediterranean fever gene mutation encoding pyrin Q148. (11588211)	Booth D.R.... Hawkins P.N.	2001	MEFV
44	E148Q of the MEFV gene causes amyloidosis in familial Mediterranean fever patients. (11452963)	Akar N.... YalAsinkaya F.	2001	MEFV
45	Identification of MEFV-independent modifying genetic factors for familial Mediterranean fever. (11017802)	Cazeneuve C.... Amselem S.	2000	SAA1, SAA2
46	MEFV-Gene analysis in Armenian patients with familial Mediterranean fever: diagnostic value and unfavorable renal prognosis of the M694V homozygous genotype-genetic and therapeutic implications. (10364520)	Cazeneuve C.... Amselem S.	1999	MEFV
47	Induced TNF production in vitro as a test for familial Mediterranean fever. (8731564)	Schattner A.... Hahn T.	1996	TNF
48	Familial Mediterranean Fever (20301405)	Shohat M.... Halpern G.J.	1993	MEFV
49	Tumor necrosis factor in familial Mediterranean fever. (1580310)	Ozyilkan E.... Telatar H.	1992	TNF
50	Determination of autoantibodies in patients with familial Mediterranean fever and their first degree relatives. (2066952)	Swissa M.... Shoenfeld Y.	1991	RNPC3

Genes related to familial mediterranean fever according to GeneCards:

(show top 50)    (show all 107)

id	Symbol	Description	Score	GeneCards Section Context
1	MEFV	Mediterranean fever	11.1	Publications
2	SAA1	serum amyloid A1	11.0	Publications
3	SAA2	serum amyloid A2	11.0	Publications
4	SAA4	serum amyloid A4, constitutive	11.0	Publications
5	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	11.0	Publications
6	NLRP3	NLR family, pyrin domain containing 3	11.0	Publications
7	CASP1	caspase 1, apoptosis-related cysteine peptidase	11.0	Publications
8	MVK	mevalonate kinase	11.0
9	NOD2	nucleotide-binding oligomerization domain containing 2	11.0
10	GSN	gelsolin	11.0
11	DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	11.0
12	IL1B	interleukin 1, beta	11.0	Publications
13	HLA-A	major histocompatibility complex, class I, A	11.0	Publications
14	CRP	C-reactive protein, pentraxin-related	11.0	Publications
15	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0
16	TNF	tumor necrosis factor	11.0	Publications
17	KIR2DP1	killer cell immunoglobulin-like receptor, two domains, pseudogene 1	11.0	Publications
18	KIR3DP1	killer cell immunoglobulin-like receptor, three domains, pseudogene 1	11.0	Publications
19	CARD17	caspase recruitment domain family, member 17	11.0	Disorders
20	SIVA1	SIVA1, apoptosis-inducing factor	11.0	Publications
21	ZNF200	zinc finger protein 200	11.0	Publications
22	PYCARD	PYD and CARD domain containing	11.0	Publications
23	KIR2DS3	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3	11.0	Publications
24	KIR2DS5	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5	11.0	Publications
25	KIR2DL5A	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A	11.0	Publications
26	KIR2DS2	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2	11.0	Publications
27	KIR2DS1	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	11.0	Publications
28	OR2C1	olfactory receptor, family 2, subfamily C, member 1	11.0	Publications
29	ZNF213	zinc finger protein 213	11.0	Disorders
30	ZNF205	zinc finger protein 205	11.0
31	KIR3DL3	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3	11.0	Publications
32	PDE1B	phosphodiesterase 1B, calmodulin-dependent	11.0	Publications
33	KIR2DL2	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2	11.0	Publications
34	KIR2DL4	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4	11.0	Publications
35	OR1F1	olfactory receptor, family 1, subfamily F, member 1	11.0	Publications
36	LYZ	lysozyme	11.0
37	HAGH	hydroxyacylglutathione hydrolase	11.0	Publications
38	KIR3DS1	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1	11.0	Publications
39	KIR2DS4	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4	11.0	Publications
40	NLRP11	NLR family, pyrin domain containing 11	11.0	Publications
41	TRIM27	tripartite motif containing 27	11.0
42	RNPC3	RNA-binding region (RNP1, RRM) containing 3	11.0	Publications
43	KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	11.0	Publications
44	GPX3	glutathione peroxidase 3 (plasma)	11.0	Publications
45	FCGR1A	Fc fragment of IgG, high affinity Ia, receptor (CD64)	11.0	Publications
46	ATN1	atrophin 1	11.0	Publications
47	GLO1	glyoxalase I	11.0	Publications
48	ABCC6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	11.0	Publications
49	IDS	iduronate 2-sulfatase	11.0
50	HP	haptoglobin	11.0	Publications

Pathways related to familial mediterranean fever according to GeneDecks:

(show top 50)    (show all 94)

id	Pathway	Score	Top Affiliating Genes
1	Immune response Role of DAP12 receptors in NK cells10	10.5	KIR2DL2, KIR2DL1, KIR2DL4, KIR2DS2, KIR2DL5A, KIR2DS1
2	Bacterial infections in CF airways41	10.5	CTSB, TLR2, IL1R1
3	Immune response_Role of DAP12 receptors in NK cells41	10.4	HLA-B, KIR2DS1, KIR2DL1, KIR2DL4, KIR2DL5A, KIR2DL3
4	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.4	TNFRSF1A, IL2RA, CCL3
5	Graft-versus-host disease20	10.4	KIR2DL3, KIR2DL1, KIR3DL1, KIR2DL5A, KIR3DL2, HLA-B
6	Inflammasome Activation Pathways37	10.3	TLR4, TLR2, NLRP3, CASP1, IL1R1, IL18
7	Immune response_Bacterial infections in normal airways41	10.3	IL1R1, IFNG, CD14, IL1B
8	NFAT Signaling and Lymphocyte Interactions36	10.2	IL12A, CCL3
9	NOD-like receptor signaling pathway20	10.2	IL18, CASP1, PSTPIP1, IL1B, PYCARD, IL6
10	PGC1Alpha Pathway36	10.0	TNFRSF1A, IL8, IL1R1, IL1B, IL18, IL12A
11	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.0	TNF, FAS, IL12A, TNFRSF1A, IL2RA, IL10
12	TRAF Pathway36	9.9	IL1B, IL1R1, TNF, TNFRSF1A, IL12A, TLR2
13	MSP-RON Signaling36	9.9	TLR4, ITGAM, TLR2, TNF, IFNG, IL1B
14	IL-10 Pathway36	9.9	TNF, CD14, IL1B, IL10, TLR4, IL6
15	Th1 Differentiation37	9.7	TLR2, IL10, IL12A, IFNG, TNF, TLR4
16	HMGB1 Pathway36	9.7	TNF, IL1R1, TNFRSF1A, TLR4, IL1B, IFNG
17	Amoebiasis20	9.7	CD14, TLR2, ITGAM, IL12A, IL1B, IL1R1
18	Pertussis20	9.7	CD14, TLR4, NLRP3, PYCARD, CASP1, IL6
19	Immune response MIF in innate immunity response10	9.7	IL1B, CD14, IL6, IL8, IFNG, TNF
20	Immune response_MIF in innate immunity response41	9.6	CD14, IL1B, TLR4, TNF, IFNG, IL8
21	Antigen processing and presentation20	9.6	KIR2DS3, CTSB, HLA-DRB1, HLA-DQB1, KIR2DL2, KIR2DS1
22	Selected targets of GCR-alpha10	9.6	LEP, IL1B, IL6, TLR2, THBD, C5AR1
23	Natural killer cell mediated cytotoxicity20	9.6	KIR3DL1, KIR2DS4, KIR2DL4, KIR2DL3, KIR2DL1, KIR3DL2
24	Immune System38	9.6	SAA1, MEFV, FCGR1A, IL18, IL1R1, IFNG
25	Cytokine Network36	9.6	IL6, IL12A, TNF, IFNG, IL8, IL1B
26	Toll-like receptor signaling pathway20	9.5	TLR2, TLR4, IL6, IL8, CD14, CCL3
27	Staphylococcus aureus infection20	9.5	HLA-DRB1, FCGR1A, ITGAM, SELP, IL10, C5AR1
28	Endothelin-1 Signaling Pathway36	9.5	IL18, IL12A, IL6, CCL3, CASP1, IL10
29	Hematopoietic cell lineage20	9.4	IL6, TNF, TFRC, HLA-DRB1, IL2RA, IL1R1
30	African trypanosomiasis20	9.4	IL6, APOA1, FAS, IL12A, TNF, IL10
31	Type I diabetes mellitus20	9.3	TNF, HLA-DQB1, HLA-B, HLA-A, HLA-DRB1, IL1B
32	MIF Mediated Glucocorticoid Regulation36	9.3	CCL3, IL10, TLR4, IL12A, IL18, IL1B
33	THC Differentiation Pathway36	9.3	TNF, HLA-DRB1, HLA-DQB1, IL18, IL12A, IL10
34	MIF Regulation of Innate Immune Cells36	9.3	IL6, CD14, IL10, TNF, CCL3, IL8
35	STAT3 Pathway36	9.3	IL2RA, IL1R1, IL1B, IL12A, IL18, IL8
36	Leishmaniasis20	9.3	TLR2, ITGAM, IL10, IL12A, IL1B, IFNG
37	Phagosome20	9.2	FCGR1A, HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, TLR2
38	Malaria20	9.2	IL12A, SELP, IL10, IL18, IL1B, IL6
39	Toxoplasmosis20	9.2	HLA-DQB1, IFNG, IL10, IL12A, HLA-DRB1, TLR4
40	Glucocorticoid Receptor Signaling36	9.1	IL2RA, IL1R1, IL1B, IL18, IL10, CCL3
41	Allograft rejection20	9.1	TNF, HLA-B, HLA-DRB1, HLA-DQB1, HLA-A, IFNG
42	TGF-Beta Pathway36	9.1	IL10, IL12A, IL18, IL1R1, IL1B, TIMP1
43	Tec Kinases Signaling36	9.0	IL10, ITGAM, IL8, CCL3, TLR2, TLR4
44	MAPK Family Pathway36	9.0	TIMP1, TNFRSF1A, TNF, CCL3, IL6, IL1R1
45	Influenza A20	8.7	PYCARD, IL12A, TNFRSF1A, FAS, NLRP3, TLR4
46	Tuberculosis20	8.6	CD14, FCGR1A, ITGAM, TNFRSF1A, TLR2, NOD2
47	JAK-STAT Pathway36	8.5	IL1B, IL1R1, IL2RA, TIMP1, F2, IL6
48	Chagas disease (American trypanosomiasis)20	8.4	IL8, FAS, CCL3, IFNG, TNF, ACE
49	Rheumatoid arthritis20	7.9	IL1B, IL8, HLA-DQB1, TLR2, CCL3, TLR4
50	Cytokine-cytokine receptor interaction20	7.4	IL18, IL10, LEP, IL6, TNF, VEGFA

Compounds related to familial mediterranean fever according to GeneDecks:

(show top 50)    (show all 382)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.7	HAGH, GLO1, GSN
2	ivig32	10.6	CRP, IL1RAPL2, FCGR1A
3	polyethylene glycol32	10.3	HP, APOA1, SERPINC1, THBD, TFRC
4	anakinra32 9 9	11.5	NLRP3, CRP, TNFRSF11B, TNF, CASP1, IL6
5	n acetylcysteine32	9.4	IL2RA, IL1R1, IL18, MMP1, ITGAM, SERPINC1
6	endotoxin32	9.3	GSN, ITGAM, CD14, SAA4, SAA1, SELL
7	cuprophan32	9.3	TNFRSF1A, CASP1, IL2RA, IL1RN, IL1RAPL2, IL1R1
8	aspartate32	9.1	HLA-DQB1, HP, CASP1, F2, CCL3, APOA1
9	latex32	8.9	ITGAM, CD14, SAA4, GSN, FCGR1A, TIMP1
10	sb 20358032 42	9.8	C5AR1, TIMP1, CRP, TNFRSF11B, TNF, CASP1
11	fmlp32	8.8	IL1RN, IL1RAPL2, IL1B, FCGR1A, GSN, ITGAM
12	pge132	8.8	ADM, TFRC, TF, THBD, PLAT, APOH
13	leukotriene b432 42 18	10.7	C5AR1, CXCR2, TLR2, TNF, CCL3, IL8
14	p00232	8.7	ADM, TIMP1, LSL, PLAT, CRP, TNFRSF1A
15	calcitriol32 42 9 18 9	12.7	TFRC, THBD, TIMP1, TLR2, TNFRSF11B, ALB
16	8-isoprostane32	8.6	SERPINE1, LEP, SAA4, TF, THBD, CRP
17	peptidoglycan32	8.6	CASP1, CCL3, IL8, IL6, IL1RN, IL1R1
18	superoxide32 18	9.5	CASP1, GPX3, APOH, IL8, IL1RN, IL1RAPL2
19	chloroquine32 34 9 9	11.5	TFRC, TF, TLR4, ABCB1, CTSB, TNFRSF1A
20	lipoteichoic acid32	8.3	HLA-B, CCL3, APOH, IL8, IL6, IL1RN
21	tacrolimus32 34 9 9	11.3	CASP1, IFNG, CCL3, APOA1, IL2RA, IL18
22	il 1032	8.2	TLR4, TLR2, NOD2, TNF, IFNG, CCL3
23	polymyxin b32	8.2	TLR2, TNFRSF11B, TNF, IFNG, IL8, IL6
24	hydrocortisone32 9 9	10.0	MMP1, CD14, IL10, ADM, TF, ABCB1
25	cysteine32	7.9	TFRC, THBD, TIMP1, PLAT, CTSB, TNFRSF1A
26	etanercept32 9 9	9.8	TNF, IFNG, APOH, IL8, IL6, IL1RN
27	norepinephrine32 9 18 9	10.8	CRP, TNFRSF1A, IL6, IL2RA, IL1RN, IL1RAPL2
28	ly29400232	7.8	TNF, CCL3, IL8, IL6, IL1B, IL18
29	testosterone32 9 18 9	10.8	TFRC, ABCB1, LSL, TNFRSF1A, TNFRSF11B, HLA-B
30	heparin32 9 18 9	10.7	C5AR1, CXCR2, TIMP1, LSL, CTSB, TNFRSF11B
31	rantes32	7.7	IL1RAPL2, IL1R1, IL18, MMP1, ITGAM, CD14
32	prostacyclin32	7.7	PLAT, CRP, TNFRSF1A, TNF, APOH, APOA1
33	estrogen32	7.6	F2, APOH, APOA1, IL1RN, IL18, FCGR1A
34	neopterin32	7.5	TNFRSF1A, TNF, HP, IFNG, CCL3, IL8
35	vegf32	7.3	IL1RN, IL1RAPL2, IL1R1, IL1B, MMP1, ITGAM
36	vitamin d32	7.0	C5AR1, TFRC, THBD, TIMP1, TLR4, TLR2
37	atorvastatin32 34 9 18 9	10.9	TNF, APOA1, IL6, IL2RA, IL1RN, IL18
38	genistein32 9 18 9	9.7	TLR4, ABCB1, TNFRSF11B, TNF, IFNG, FAS
39	actinomycin d32	6.6	ADM, TFRC, THBD, TIMP1, TLR4, TLR2
40	prednisolone32 9 9	8.3	C5AR1, TF, THBD, IL1R1, IL18, IL10
41	methotrexate32 34 42 9 9	9.9	ADA, TF, TIMP1, IL1RN, IL1RAPL2, IL1R1
42	indomethacin32 9 9	7.8	B2M, LEP, SELL, ITGAM, GLO1, ALB
43	nitric oxide32 9 18 9	8.5	C5AR1, GLO1, CASP1, IFNG, GPX3, CCL3
44	serine32	5.4	IL18, FCGR1A, GSN, MMP1, ITGAM, CD14
45	tyrosine32	5.4	PSTPIP1, TFRC, THBD, TIMP1, TLR4, TLR2
46	lactate32	5.1	HAGH, ADA, ADM, DBH, TFRC, TF
47	cholesterol32 9 18 9	8.0	CD14, B2M, SAA4, SAA1, MVK, LEP
48	fibrinogen32	4.9	C5AR1, CXCR2, TF, THBD, TLR4, TLR2
49	cycloheximide32	4.6	ADM, C5AR1, TFRC, THBD, TIMP1, IL1RAPL2
50	cyclosporin a32 42	5.4	TLR4, TLR2, ABCB1, RNPC3, PLAT, CTSB

Cellular components related to familial mediterranean fever according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	high-density lipoprotein particle	GO:034364	10.3	APOH, APOA1, SAA4, SAA2, SAA1
2	MHC class I protein complex	GO:042612	9.8	HLA-B, HLA-A, MICA, B2M
3	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.7	HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
4	ER to Golgi transport vesicle membrane	GO:012507	9.6	HLA-DRB1, HLA-DQB1, HLA-B, HLA-A, B2M
5	secretory granule	GO:030141	9.2	DBH, TF, PLAT, APOA1, IL1B, VEGFA
6	integral to plasma membrane	GO:005887	8.6	HLA-B, HLA-DRB1, TRIM27, TNF, TNFRSF1A, TLR2
7	cell surface	GO:009986	8.4	NOD2, ABCB1, TLR2, THBD, CXCR2, ADA
8	external side of plasma membrane	GO:009897	8.4	CTSB, ACE, TLR2, TLR4, ADA, TNF
9	plasma membrane	GO:005886	5.3	ABCB1, NOD2, TNFRSF1A, TNF, HLA-DRB1, HLA-DQB1
10	extracellular region	GO:005576	5.0	TNFRSF11B, HP, CASP1, ALB, F2, IFNG
11	extracellular space	GO:005615	4.1	ADA, GPX3, IFNG, F2, ALB, HP

Biological processes related to familial mediterranean fever according to GeneDecks:

(show top 50)    (show all 63)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:035872	10.9	PSTPIP1, NLRP3, NOD2, PYCARD, CASP1, MEFV
2	negative regulation of inflammatory response	GO:050728	10.6	ADA, NLRP3, TNFRSF1A, APOA1, MEFV, SAA1
3	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	10.5	TNF, IFNG, IL1B
4	positive regulation of interferon-gamma production	GO:032729	10.4	TLR4, TNF, IL1B, IL18, IL12A
5	positive regulation of NF-kappaB import into nucleus	GO:042346	10.4	TLR4, TLR2, TNF, IL1B
6	negative regulation of interleukin-6 production	GO:032715	10.4	TLR4, TNFRSF1A, TNF, IL10
7	positive regulation of interleukin-6 production	GO:032755	10.4	TLR4, TLR2, NOD2, TNF, IL6, IL1B
8	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.3	TLR4, TLR2, NLRP3, NOD2, PYCARD, TNF
9	positive regulation of interleukin-1 beta secretion	GO:050718	10.3	NLRP3, NLRP2, NOD2, PYCARD, CASP1, IFNG
10	negative regulation of lipid storage	GO:010888	10.3	IL6, TNF, CRP
11	negative regulation of cytokine secretion involved in immune response	GO:002740	10.3	TNF, APOA1, IL10
12	lipopolysaccharide-mediated signaling pathway	GO:031663	10.3	TLR4, TLR2, TNF, CCL3, IL1B, IL18
13	positive regulation of nitric oxide biosynthetic process	GO:045429	10.3	TLR4, TLR2, TNF, IFNG, IL1B
14	positive regulation of cytokine secretion	GO:050715	10.2	TLR2, TNF, IL10, CD14, SAA1
15	chronic inflammatory response to antigenic stimulus	GO:002439	10.2	IL1RN, IL1B
16	negative regulation of interleukin-17 production	GO:032700	10.2	TLR4, TLR2, IFNG, IL12A
17	regulation of immune response	GO:050776	10.2	KIR2DL2, SELL, B2M, HLA-A, HLA-B, KIR2DS1
18	cellular response to mechanical stimulus	GO:071260	10.2	TLR4, TNFRSF1A, CASP1, FAS, IL1B, IL18
19	positive regulation of chemokine production	GO:032722	10.2	TLR4, TLR2, TNF, IL6, IL18
20	defense response to Gram-positive bacterium	GO:050830	10.2	C5AR1, TLR2, TNF, IL6, IL12A
21	defense response to bacterium	GO:042742	10.1	LYZ, TLR4, NOD2, TNFRSF1A, IFNG, IL10
22	positive regulation of interleukin-8 production	GO:032757	10.1	TLR4, TLR2, IL1B, IL18, SERPINE1
23	negative regulation of growth of symbiont in host	GO:044130	10.1	TLR2, TNF, IFNG, IL10
24	detection of bacterium	GO:016045	10.0	HLA-A, HLA-B, HLA-DRB1, NOD2
25	cellular response to lipoteichoic acid	GO:071223	10.0	CD14, TLR2, TLR4
26	neutrophil chemotaxis	GO:030593	10.0	C5AR1, CXCR2, IFNG, CCL3, IL8, IL1B
27	response to lipopolysaccharide	GO:032496	10.0	ADM, THBD, TLR4, TNFRSF1A, CASP1, FAS
28	positive regulation of leukocyte migration	GO:002687	9.9	SELP, TLR2
29	aging	GO:007568	9.9	ADA, ADM, TIMP1, FAS, IL1B, GSN
30	negative regulation of fibrinolysis	GO:051918	9.9	SERPINE1, APOH, F2, THBD
31	innate immune response	GO:045087	9.9	PSTPIP1, TLR4, TLR2, NLRP3, NLRC5, NOD2
32	positive regulation of inflammatory response	GO:050729	9.9	TLR4, TLR2, TNFRSF1A, CCL3, IL18, SERPINE1
33	leukocyte migration	GO:050900	9.8	DBH, THBD, F2, MMP1, ITGAM, SELP
34	acute-phase response	GO:006953	9.8	CRP, F2, IL6, IL1RN, SAA4, SAA2
35	defense response to Gram-negative bacterium	GO:050829	9.8	TLR4, IL6, SERPINE1, SELP
36	positive regulation of tumor necrosis factor production	GO:032760	9.8	TLR4, TLR2, NOD2, TNFRSF1A, IFNG, CCL3
37	response to peptide hormone stimulus	GO:043434	9.6	DBH, TIMP1, PLAT, CTSB, FAS
38	interferon-gamma-mediated signaling pathway	GO:060333	9.6	HLA-DRB1, HLA-DQB1, HLA-B, HLA-A, IFNG, FCGR1A
39	positive regulation of cell adhesion	GO:045785	9.5	SELP, VEGFA, SAA1, IL12A, IFNG
40	cellular response to lipopolysaccharide	GO:071222	9.4	TLR4, PYCARD, IFNG, IL8, IL10, CD14
41	cytokine-mediated signaling pathway	GO:019221	9.3	TNFRSF1A, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A, IFNG
42	inflammatory response	GO:006954	9.2	TNF, TNFRSF1A, CRP, NLRP3, TLR2, CXCR2
43	signal transduction	GO:007165	9.2	NLRP3, TLR2, PSTPIP1, OR1F1, CXCR2, C5AR1
44	response to glucocorticoid stimulus	GO:051384	9.0	ADM, PLAT, TNF, FAS, IL6, IL1RN
45	response to drug	GO:042493	8.9	ABCC6, ABCB1, TNFRSF11B, TNF, CASP1, IFNG
46	response to hypoxia	GO:001666	8.7	ADA, ADM, TLR4, PLAT, CRP, TNFRSF1A
47	platelet degranulation	GO:002576	8.5	TF, TIMP1, ALB, APOA1, VEGFA, SERPINE1
48	immune response	GO:006955	8.2	C5AR1, IL2RA, IL8, HLA-A, HLA-B, HLA-DQB1
49	platelet activation	GO:030168	8.0	TF, TIMP1, ALB, F2, APOA1, IL6
50	blood coagulation	GO:007596	7.5	F2, ALB, PLAT, TIMP1, THBD, TF

Molecular functions related to familial mediterranean fever according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	peptidoglycan binding	GO:042834	10.0	TLR2, NLRP3, NOD2
2	transmembrane signaling receptor activity	GO:004888	9.9	THBD, TLR4, TLR2, IL1R1, KIR2DS1, KIR2DS2
3	protease binding	GO:002020	9.9	TNFRSF1A, TNF, IL1R1, SERPINE1, SERPINC1, SELL
4	cysteine-type endopeptidase activity	GO:004197	9.6	CASP16, CASP1, CARD17, PYCARD, CTSB
5	cytokine activity	GO:005125	8.6	TNFRSF11B, TNF, IFNG, IL6, IL1B, IL18
6	growth factor activity	GO:008083	8.3	VEGFA, LEP, IL10, IL12A, IL1B, IL6
7	protein binding	GO:005515	4.3	ADA, NLRC5, NOD2, PLAT, CRP, CTSB