FMF
MCID: FML018
MIFTS: 74

Familial Mediterranean Fever (FMF) malady

Genetic diseases category

Summaries for Familial Mediterranean Fever

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Sources:
21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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MedlinePlus:33 A fever is a body temperature that is higher than normal. it is not an illness. it is part of your body's defense against infection. most bacteria and viruses that cause infections do well at the body's normal temperature (98.6 f). a slight fever can make it harder for them to survive. fever also activates your body's immune system. infections cause most fevers. there can be many other causes, including medicines heat exhaustion cancers autoimmune diseases treatment depends on the cause of your fever. your health care provider may recommend using over-the-counter medicines such as acetaminophen or ibuprofen to lower a very high fever. adults can also take aspirin, but children with fevers should not take aspirin. it is also important to drink enough liquids to prevent dehydration.

MalaCards: Familial Mediterranean Fever, also known as benign paroxysmal peritonitis, is related to amyloidosis and arthritis. An important gene associated with Familial Mediterranean Fever is MEFV (Mediterranean fever), and among its related pathways are Immune System and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drug colchicine and the compounds endotoxin and mevalonate have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and bone, and related mouse phenotypes are integument and immune system.

Genetics Home Reference:21 Familial Mediterranean fever is an inherited condition characterized by recurrent episodes of painful inflammation in the abdomen, chest, or joints. These episodes are often accompanied by fever and sometimes a rash. The first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. Typically, episodes last 12 to 72 hours and can vary in severity. The length of time between attacks is also variable. Without treatment to help prevent attacks and complications, a buildup of certain protein deposits (amyloidosis) in the body's organs and tissues may occur, which can lead to kidney failure.

NIH Rare Diseases:42 Familial mediterranean fever (fmf) is an inherited condition characterized by episodes of painful inflammation of the abdominal lining (peritonitis),  lining surrounding the lungs (pleurisy), and joints (arthralgia and occasionally arthritis). these episodes are often accompanied by fever and sometimes a characteristic ankle rash. the first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. between attacks, people often do not have any symptoms. without treatment, fmf can lead to kidney failure due to a buildup of certain protein deposits (amyloidosis). fmf is usually inherited in an autosomal recessive fashion and is caused by mutations in the mefv gene. last updated: 6/29/2012

Wikipedia:63 Familial Mediterranean fever (FMF), also known as Armenian disease, is a hereditary inflammatory... more...

Description from OMIM:46 249100

GeneReviews summary for fmf

Aliases & Classifications for Familial Mediterranean Fever

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Sources:
8Disease Ontology, 63Wikipedia, 19GeneReviews, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 46OMIM, 34MeSH, 27ICD9CM, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases


Aliases & Descriptions:

familial mediterranean fever 8 19 42 21 10 44 60
benign paroxysmal peritonitis 8 63 42 21
mediterranean fever, familial 63 20 22 21
familial paroxysmal polyserositis 63 42 21
recurrent polyserositis 63 19 21
periodic disease 63 42 21
fmf 63 42 21
hereditary periodic fever syndromes 21 44
wolff periodic disease 63 21
periodic peritonitis 63 21
periodic fever 42 60
fever 63 33
hereditary autoinflammatory diseases 60
hereditary periodic fever syndrome 63
siegal-cattan-mamou disease 21
reimann periodic disease 21
mef 21


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Disease Ontology8 DOID:2987
OMIM46 249100
MeSH34 D010505
SNOMED-CT56 12579009
ICD9CM27 277.31
NCIt39 C84707
ICD1025 R50.8, R50.9

Related Diseases for Familial Mediterranean Fever

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17GeneCards, 18GeneDecks
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Diseases in the Familial Mediterranean Fever family:

Familial Mediterranean Fever Type 1 Familial Mediterranean Fever Type 2
Familial Mediterranean Fever, Ar Familial Mediterranean Fever, Ad

Diseases related to Familial Mediterranean Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1016)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis31.5SAA2, SAA4, SAA1, TNFRSF1A, CRP, MEFV
2arthritis31.1TNFRSF1A, TNF, IL1B
3multiple sclerosis30.8CASP1, TNFRSF1A, TNF, HLA-A, IL1B
4glomerulonephritis30.8IL1B
5encephalitis30.8IL1B
6rheumatoid arthritis30.7CASP1, SAA2, SAA4, SAA1, TNFRSF1A, TNF
7systemic lupus erythematosus30.7NOD2, CRP, HLA-A, TNF, TNFRSF1A
8malaria30.7HLA-A, TNF
9crohn's disease30.7NOD2, CRP, TNF
10vasculitis30.7MEFV, CRP, TNF
11erysipelas30.7MEFV
12spondylitis30.6NOD2
13ankylosing spondylitis30.6NOD2, CRP, TNF, TNFRSF1A
14celiac disease30.6HLA-A
15kawasaki disease30.6CRP
16measles30.6HLA-A
17brucellosis30.5SAA1, MEFV
18hepatitis30.5HLA-A, DBH
19atherosclerosis30.5SAA4, SAA1, TNF, CRP, IL1B, NOD2
20peritonitis30.5IL1B, MEFV, CRP, TNF
21tuberculosis30.5TNFRSF1A, TNF, HLA-A, CRP, IL1B, NOD2
22influenza30.4HLA-A, CASP1
23pericarditis30.4MEFV
24myositis30.4CASP1
25periodontitis30.4IL1B
26inflammatory bowel disease30.4TNFRSF1A, IL1B
27septic arthritis30.4CRP
28adult-onset still's disease30.4CRP
29sarcoidosis30.4NOD2, IL1B, HLA-A, TNF
30myopathy30.4MVK, CRP, GSN
31appendicitis30.4CRP
32relapsing fever30.4MVK, TNFRSF1A, MEFV
33ulcerative colitis30.4CASP1, TNF, CRP, IL1B, NOD2
34rheumatic fever30.4CRP
35acute leukemia30.3CASP1
36tumor necrosis factor receptor-associated periodic syndrome30.2MVK, TNFRSF1A, TNF, MEFV
37leishmaniasis30.2TNFRSF1A
38mevalonic aciduria30.2MVK
39myocardial infarction30.2CASP1, SAA4, SAA1, CRP
40palindromic rheumatism30.2MEFV
41alzheimer's disease30.2CASP1, SAA4, TNFRSF1A, DBH, IL1B, GSN
42osteomyelitis30.2CRP
43leukemia30.2CASP1, TNFRSF1A, TNF, HLA-A, DBH, IL1B
44psoriatic arthritis30.2CRP, TNF
45psoriasis30.2NOD2, IL1B, HLA-A, TNF, TNFRSF1A, CASP1
46asthma30.2TNF, IL1B, NOD2, GSN
47gingivitis30.2IL1B
48pancreatitis30.2IL1B, CRP, CASP1
49meningitis30.2SAA4, CRP, IL1B
50fabry disease30.2DBH

Graphical network of the top 20 diseases related to Familial Mediterranean Fever:



Diseases related to familial mediterranean fever

Clinical Features for Familial Mediterranean Fever

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46OMIM
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Clinical features from OMIM:

249100

Drugs & Therapeutics for Familial Mediterranean Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Familial Mediterranean Fever

Drug clinical trials:

Search ClinicalTrials for Familial Mediterranean Fever

Search NIH Clinical Center for Familial Mediterranean Fever

Search CenterWatch for Familial Mediterranean Fever

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Familial Mediterranean Fever

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20GeneTests, 22GTR
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Genetic tests related to Familial Mediterranean Fever:

id Genetic test Affiliating Genes
1 Familial Mediterranean Fever20 22 MEFV

Anatomical Context for Familial Mediterranean Fever

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32MalaCards
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MalaCards organs/tissues related to Familial Mediterranean Fever:

32
Kidney, Lung, Bone, Thyroid, Testes, Endothelial, Liver, Heart, Skin, Bone marrow, Colon, Breast, Brain, Monocytes, T cells

Animal Models for Familial Mediterranean Fever or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Familial Mediterranean Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.5GSN, DBH, MEFV, CASP1, NLRP3
2MP:000538710.4GSN, PYCARD, NLRP3, CASP1, TNFRSF1A, TNF
3MP:000537610.2TNFRSF1A, SAA1, CASP1, NLRP3, PYCARD, TNF

Publications for Familial Mediterranean Fever

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50PubMed
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Articles related to Familial Mediterranean Fever:

(show top 50)    (show all 724)
idTitleAuthorsYear
1
Thyroid autoimmunity in patients with Familial Mediterranean Fever: preliminary results. (24302182)
2013
2
The risk of familial Mediterranean fever in MEFV heterozygotes: a statistical approach. (23844200)
2013
3
Three Japanese patients (mother and two children) with familial Mediterranean fever associated with compound heterozygosity for L110P/E148Q/M694I and an autosomal true dominant inheritance pattern. (24383976)
2013
4
Assesment life quality of familial Mediterranean fever patients by short form-36 and its relationship with disease parameters. (23640444)
2013
5
Activated phenotype of circulating neutrophils in familial Mediterranean fever. (23182715)
2013
6
Mediterranean Fever gene analysis in the azeri turk population with familial mediterranean Fever: evidence for new mutations associated with disease. (23862117)
2013
7
Efficacy and safety of biologic treatments in Familial Mediterranean Fever. (23276893)
2013
8
Corrigendum: novel therapeutics for the treatment of familial mediterranean Fever: from colchicine to biologics. (24352151)
2013
9
The relative contribution of environmental and genetic factors to phenotypic variation in familial Mediterranean fever (FMF). (22019429)
2012
10
Nonalcoholic fatty liver disease and familial Mediterranean fever: are they related? (23289274)
2012
11
Summaries for patients. Therapy for patients with familial Mediterranean fever when colchicine is not enough or is not tolerated. (23070503)
2012
12
Pregnancy outcome in women with familial Mediterranean fever. (23075349)
2012
13
Evaluation of the mean platelet volume in children with familial Mediterranean fever. (22086472)
2012
14
Infantile colitis as a novel presentation of familial Mediterranean fever responding to colchicine therapy. (21694544)
2011
15
Assessment of heart rate recovery index in patients with familial Mediterranean fever. (20652273)
2011
16
Colchicine and ocular surface changes in familial Mediterranean fever. (19681787)
2010
17
Protracted synovitis without systemic manifestations in familial Mediterranean fever (FMF). (20868584)
2010
18
A rare presentation of familial mediterranean Fever; acute scrotum and hydrocele amyloidosis. (23056732)
2010
19
Familial Mediterranean Fever in the first two years of life: a unique phenotype of disease in evolution. (20227729)
2010
20
Increased serum concentrations of homocysteine and lipoprotein (a) in familial Mediterranean fever. (20124324)
2010
21
A rare cause of refractory ascites in a child: familial Mediterranean fever. (19466424)
2010
22
Familial Mediterranean fever and membranous glomerulonephritis: report of a case. (20370460)
2010
23
Protracted febrile myalgia syndrome in familial Mediterranean fever. (20352466)
2010
24
Scleritis and sudden hearing loss associated with familial Mediterranean fever. (20868588)
2010
25
Serum adiponectin levels in patients with familial Mediterranean fever. (20518740)
2010
26
The crystal structure of human pyrin b30.2 domain: implications for mutations associated with familial Mediterranean fever. (19729025)
2009
27
A very frequent mutation and remarkable association of R761H with M694V mutations in Turkish familial Mediterranean fever patients. (18000697)
2008
28
Protracted febrile myalgia syndrome in a patient with familial Mediterranean fever homozygous for the E148Q mutation. (18191992)
2008
29
Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever. (18849241)
2008
30
MEFV mutations in patients with familial Mediterranean fever in the Black Sea region of Turkey: Samsun experience [corrected]. (18061974)
2008
31
Platelet activation in patients with Familial Mediterranean Fever. (18925507)
2008
32
Familial Mediterranean fever gene as a possible modifier of Sweet syndrome with chronic myelogenous leukemia. (18824843)
2008
33
Successful treatment with infliximab and low-dose methotrexate in a Japanese patient with familial Mediterranean fever. (17675778)
2007
34
Familial Mediterranean fever: MEFV gene mutations and treatment]. (17473509)
2007
35
The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. (16785446)
2006
36
Serum amyloid A1 -13 T/C alleles in Turkish familial Mediterranean fever patients with and without amyloidosis. (16874691)
2006
37
Two sisters with familial Mediterranean fever: lack of correlation between genotype and phenotype? (16523434)
2006
38
Comparison of amplification refractory mutation system and polymerase chain reaction-restriction fragment length polymorphism techniques used for the investigation of MEFV gene exon 10 point mutations in familial Mediterranean fever patients living in Cukurova region (Turkey). (16225401)
2005
39
Serum interleukin 17 and interleukin 18 levels in familial Mediterranean fever. (16273770)
2005
40
The anemia of familial Mediterranean fever disease. (16251171)
2005
41
The efficacy of interferon-alpha in a patient with resistant familial Mediterranean fever complicated by polyarteritis nodosa. (15335192)
2004
42
A case of osteopoikilosis coexisting with amyloidosis of familial Mediterranean fever. (14586673)
2003
43
Familial Mediterranean fever presenting as recurrent acute pelvic inflammatory disease. (12738114)
2003
44
Familial mediterranean fever - a review and update. (11740430)
2001
45
Familial Mediterranean Fever: association of elevated IgD plasma levels with specific MEFV mutations. (11781702)
2001
46
E148Q of the MEFV gene causes amyloidosis in familial Mediterranean fever patients. (11452963)
2001
47
Familial Mediterranean fever: from the clinical syndrome to the cloning of the pyrin gene. (9572633)
1998
48
Seronegative spondyloarthropathy in familial Mediterranean fever. (9355205)
1997
49
Localization of the familial Mediterranean fever gene (FMF) to a 250-kb interval in non-Ashkenazi Jewish founder haplotypes. The French FMF Consortium. (8751861)
1996
50
Familial Mediterranean fever--linkage studies with genetic markers on chromosome 6. (2278043)
1990

Genetic Variations for Familial Mediterranean Fever

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Expression for genes affiliated with Familial Mediterranean Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Mediterranean Fever

Search GEO for disease gene expression data for Familial Mediterranean Fever.

Pathways for genes affiliated with Familial Mediterranean Fever

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 12EMD Millipore, 51QIAGEN, 55SinoBiological, 4Cell Signaling Technology
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Pathways related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5PYCARD, NLRP3, CASP1, SAA1, PSTPIP1, HLA-A
2
Hide members
10.5NOD2, PYCARD, NLRP3, CASP1, TNF, PSTPIP1
3
Hide members
10.5PYCARD, NLRP3, CASP1, PSTPIP1, MEFV
410.5SAA2, SAA4, SAA1, TNF, CRP, IL1B
510.5SAA1, SAA4, SAA2
6
Hide members
10.5PYCARD, NLRP3, CASP1, TNF, IL1B, NOD2
7
Apoptosis and survival Caspase cascade
Hide members
10.5GSN, TNF, TNFRSF1A, CASP1
8
Hide members
10.5PYCARD, NLRP3, CASP1, TNFRSF1A, TNF, HLA-A
9
Hide members
10.5CASP1, TNFRSF1A, TNF
10
Hide members
10.5TNF, TNFRSF1A, CASP1
1110.5PYCARD, NLRP3, CASP1, TNF, IL1B
12
Hide members
10.5HLA-A, TNF, TNFRSF1A, CASP1
13
Hide members
10.5NOD2, IL1B, CASP1
14
Hide members
10.5IL1B, TNF, TNFRSF1A, CASP1
15
Hide members
10.5IL1B, TNF, TNFRSF1A, CASP1
16
Hide members
10.5CASP1, TNFRSF1A, TNF, IL1B
17
Hide members
10.5NOD2, IL1B, HLA-A, CASP1
1810.5CASP1, IL1B
1910.5CASP1, TNF, IL1B
2010.5TNFRSF1A, TNF, NOD2
2110.5DBH
2210.5PYCARD, CASP1
2310.5CASP1, PYCARD
24
Hide members
10.5NOD2
2510.5TNFRSF1A, TNF, IL1B, NOD2
2610.5TNFRSF1A, TNF, IL1B, NOD2
2710.5PYCARD, CASP1, TNF, IL1B
2810.5IL1B, CASP1, PYCARD
29
Hide members
10.5TNF, TNFRSF1A
3010.5TNFRSF1A, TNF, IL1B
31
Hide members
10.5IL1B, HLA-A, TNF, TNFRSF1A
3210.5IL1B, TNF, TNFRSF1A, PYCARD

Compounds for genes affiliated with Familial Mediterranean Fever

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44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1endotoxin4411.0GSN, MEFV, TNFRSF1A, SAA1, SAA4, CASP1
2mevalonate4411.0NLRP3, CASP1, MVK, TNFRSF1A, MEFV
3anakinra44 1112.0NLRP3, CASP1, MVK, TNF, CRP, IL1B
4dexamethasone44 49 28 1113.9DBH, SAA1, SAA2, CASP1
5lipid4410.9CASP1, MVK, SAA4, SAA1, TNFRSF1A, TNF
6tenidap44 2811.9SAA1
7infliximab44 49 1112.9TNFRSF1A, TNF, CRP, IL1B, NOD2
8simvastatin44 49 59 28 11 2415.9MVK, SAA1, TNFRSF1A, TNF, CRP
9neopterin4410.9SAA4, TNFRSF1A, TNF, CRP, IL1B
10etanercept44 49 1112.9TNFRSF1A, TNF, CRP, IL1B
11muramyl dipeptide44 2811.9NOD2, IL1B, CASP1
12leflunomide49 44 1112.9SAA4, TNFRSF1A, TNF, IL1B
13peptidoglycan44 2811.9CASP1, TNF, IL1B, NOD2
14alanine4410.9MVK, SAA1, TNFRSF1A, HLA-A, CRP, DBH
15methotrexate44 49 1112.9NLRP3, TNFRSF1A, TNF, CRP, IL1B
16ivig4410.9TNFRSF1A, TNF, CRP, IL1B
17superoxide44 2411.9CASP1, TNFRSF1A, TNF, DBH, IL1B, GSN
18actinomycin4410.9IL1B, TNFRSF1A
19anisomycin44 1111.9CASP1, TNFRSF1A, TNF, IL1B
20n acetylcysteine4410.9CASP1, TNFRSF1A, TNF, CRP, IL1B
21sb 20358044 5911.9CASP1, TNFRSF1A, TNF, CRP, IL1B
22staurosporin4410.9IL1B, TNF, CASP1
23tpck4410.9CASP1, TNF, IL1B
24acetyl-tyr-val-ala-asp-cho4410.9IL1B, CASP1
25cuprophan4410.9IL1B, TNFRSF1A, CASP1
26fibrinogen4410.9SAA4, SAA1, TNF, CRP, GSN
27glucose4410.8SAA4, SAA1, DBH, GSN
28okt34410.8CRP, TNF, TNFRSF1A
29sulfasalazine44 28 49 1113.8TNF, CRP, IL1B
308-isoprostane4410.8CRP, TNF, SAA4
31ns 39844 5911.8TNFRSF1A, TNF, IL1B
32turpentine4410.8CRP, IL1B
33hypericin4410.8CASP1, DBH
34tocilizumab44 1111.8TNF, CRP
35serine4410.8CASP1, MVK, TNFRSF1A, TNF, PSTPIP1, DBH
36fmlp4410.8GSN
37prostacyclin4410.8TNFRSF1A, TNF, CRP, IL1B
38poly(i-c)4410.8IL1B, TNF, CASP1
39il 104410.7NOD2, IL1B, TNF
40pge24410.7DBH
41calcium44 49 11 2413.7CASP1, SAA4, SAA1, TNFRSF1A, HLA-A, CRP
42diphenyleneiodonium4410.7IL1B, TNF, CASP1
43cdp5714410.7CRP, TNF
44nitric oxide44 11 2412.6CASP1, TNFRSF1A, TNF, DBH, IL1B, NOD2
45pentoxifylline44 1111.6CASP1
46creatinine4410.6CASP1, MVK, SAA4, TNFRSF1A, CRP
47oxygen44 2411.5TNFRSF1A, TNF, DBH, GSN, CASP1
48c2ceramide4410.5TNFRSF1A, TNF, IL1B
49bucillamine4410.4IL1B, CRP
50tlck4410.2IL1B, CASP1

GO Terms for genes affiliated with Familial Mediterranean Fever

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16Gene Ontology
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Cellular components related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6GSN, PYCARD, CASP1, SAA4, SAA1, TNFRSF1A
2NLRP3 inflammasome complexGO:07255910.6CASP1, NLRP3, PYCARD
3cytosolGO:00582910.5NLRP3, CASP1, MVK, PSTPIP1, MEFV, IL1B
4high-density lipoprotein particleGO:03436410.5SAA2, SAA4, SAA1
5AIM2 inflammasome complexGO:09716910.4CASP1, PYCARD
6NLRP1 inflammasome complexGO:07255810.2CASP1, PYCARD

Biological processes related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:05072810.9NLRP3, MVK, SAA1, TNFRSF1A, MEFV
2nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:03587210.9NOD2, MEFV, PSTPIP1, CASP1, NLRP3, PYCARD
3positive regulation of interleukin-1 beta secretionGO:05071810.9NOD2, CASP1, NLRP3, PYCARD
4inflammatory responseGO:00695410.9PYCARD, NLRP3, TNFRSF1A, TNF, CRP, MEFV
5innate immune responseGO:04508710.9PYCARD, NLRP3, CASP1, SAA1, PSTPIP1, MEFV
6acute-phase responseGO:00695310.9SAA2, SAA4, SAA1, CRP
7interleukin-1 beta productionGO:03261110.9IL1B, CASP1, PYCARD
8positive regulation of NF-kappaB transcription factor activityGO:05109210.9PYCARD, NLRP3, TNF, IL1B, NOD2
9positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.9CASP1, TNFRSF1A, TNF, IL1B, NOD2
10positive regulation of interleukin-6 productionGO:03275510.9NOD2, IL1B, TNF, PYCARD
11apoptotic processGO:00691510.9PYCARD, NLRP3, CASP1, TNFRSF1A, TNF, IL1B
12positive regulation of JNK cascadeGO:04633010.9PYCARD, TNF, IL1B, NOD2
13activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.9PYCARD, NLRP3, CASP1, TNF
14positive regulation of tumor necrosis factor productionGO:03276010.8NOD2, TNFRSF1A, PYCARD
15positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328010.8PYCARD, NLRP3, TNF
16defense response to Gram-positive bacteriumGO:05083010.8TNF, CRP, NOD2
17positive regulation of interferon-gamma productionGO:03272910.8PYCARD, TNF, IL1B
18positive regulation of calcidiol 1-monooxygenase activityGO:06055910.8TNF, IL1B
19detection of biotic stimulusGO:00959510.8NLRP3, NOD2
20sequestering of triglycerideGO:03073010.8TNF, IL1B
21response to hypoxiaGO:00166610.8CASP1, TNFRSF1A, TNF, CRP
22positive regulation of heterotypic cell-cell adhesionGO:03411610.8IL1B, TNF
23positive regulation of cysteine-type endopeptidase activityGO:200105610.8MEFV, PYCARD
24positive regulation of fever generationGO:03162210.8IL1B, TNF
25cellular response to mechanical stimulusGO:07126010.8CASP1, TNFRSF1A, IL1B
26positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.7NOD2, TNF
27negative regulation of NF-kappaB transcription factor activityGO:03208810.7NOD2, NLRP3, PYCARD
28negative regulation of lipid storageGO:01088810.7TNF, CRP
29positive regulation of chemokine biosynthetic processGO:04508010.7IL1B, TNF
30positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.6IL1B, TNF, PYCARD
31response to ethanolGO:04547110.6TNFRSF1A, CRP, GSN
32regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.6IL1B, TNF
33negative regulation of interleukin-12 productionGO:03269510.6NOD2, MEFV
34activation of MAPK activityGO:00018710.5TNF, IL1B, NOD2
35negative regulation of lipid catabolic processGO:05099510.5IL1B, TNF
36positive regulation of ERK1 and ERK2 cascadeGO:07037410.4NOD2, TNF, PYCARD
37positive regulation of membrane protein ectodomain proteolysisGO:05104410.2IL1B, TNF

Molecular functions related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:04283410.5NOD2, NLRP3
2cysteine-type endopeptidase activityGO:00419710.2CASP1, CASP16, PYCARD

Products for genes affiliated with Familial Mediterranean Fever

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Sources for Familial Mediterranean Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet