FMF
MCID: FML018
MIFTS: 73

Familial Mediterranean Fever (FMF) malady

Genetic category

Summaries for Familial Mediterranean Fever

Sources:
21Genetics Home Reference, 43NIH Rare Diseases, 34MedlinePlus, 64Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
See all sources

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MedlinePlus:34 A fever is a body temperature that is higher than normal. it is not an illness. it is part of your body's defense against infection. most bacteria and viruses that cause infections do well at the body's normal temperature (98.6 f). a slight fever can make it harder for them to survive. fever also activates your body's immune system. infections cause most fevers. there can be many other causes, including medicines heat exhaustion cancers autoimmune diseases treatment depends on the cause of your fever. your health care provider may recommend using over-the-counter medicines such as acetaminophen or ibuprofen to lower a very high fever. adults can also take aspirin, but children with fevers should not take aspirin. it is also important to drink enough liquids to prevent dehydration.

MalaCards: Familial Mediterranean Fever, also known as benign paroxysmal peritonitis, is related to amyloidosis and amyloidosis, renal. An important gene associated with Familial Mediterranean Fever is MEFV (Mediterranean fever), and among its related pathways are Immune System and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drug colchicine and the compounds endotoxin and mevalonate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are integument and immune system.

Genetics Home Reference:21 Familial Mediterranean fever is an inherited condition characterized by recurrent episodes of painful inflammation in the abdomen, chest, or joints. These episodes are often accompanied by fever and sometimes a rash. The first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. Typically, episodes last 12 to 72 hours and can vary in severity. The length of time between attacks is also variable. Without treatment to help prevent attacks and complications, a buildup of certain protein deposits (amyloidosis) in the body's organs and tissues may occur, which can lead to kidney failure.

NIH Rare Diseases:43 Familial mediterranean fever (fmf) is an inherited condition characterized by episodes of painful inflammation of the abdominal lining (peritonitis),  lining surrounding the lungs (pleurisy), and joints (arthralgia and occasionally arthritis). these episodes are often accompanied by fever and sometimes a characteristic ankle rash. the first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. between attacks, people often do not have any symptoms. without treatment, fmf can lead to kidney failure due to a buildup of certain protein deposits (amyloidosis). fmf is usually inherited in an autosomal recessive fashion and is caused by mutations in the mefv gene. last updated: 6/29/2012

Wikipedia:64 Familial Mediterranean fever (FMF), also known as Armenian disease, is a hereditary inflammatory... more...

Description from OMIM:47 249100

GeneReviews summary for fmf

Aliases & Classifications for Familial Mediterranean Fever

Sources:
8Disease Ontology, 19GeneReviews, 43NIH Rare Diseases, 21Genetics Home Reference, 10DISEASES, 45Novoseek, 61UMLS, 64Wikipedia, 20GeneTests, 22GTR, 34MedlinePlus, 47OMIM, 35MeSH, 27ICD9CM, 57SNOMED-CT, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic


Aliases & Descriptions:

familial mediterranean fever 8 19 43 21 10 45 61
benign paroxysmal peritonitis 8 64 43 21
mediterranean fever, familial 64 20 22 21
familial paroxysmal polyserositis 64 43 21
recurrent polyserositis 64 19 21
periodic disease 64 43 21
fmf 64 43 21
hereditary periodic fever syndromes 21 45
wolff periodic disease 64 21
periodic peritonitis 64 21
periodic fever 43 61
fever 64 34
hereditary autoinflammatory diseases 61
hereditary periodic fever syndrome 64
siegal-cattan-mamou disease 21
reimann periodic disease 21
mef 21


External Ids:

Disease Ontology8 DOID:2987
OMIM47 249100
MeSH35 D010505
SNOMED-CT57 12579009
ICD9CM27 277.31
NCIt40 C84707
ICD1025 R50.8, R50.9

Related Diseases for Familial Mediterranean Fever

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Familial Mediterranean Fever family:

familial mediterranean fever type 1 familial mediterranean fever type 2
familial mediterranean fever, ar familial mediterranean fever, ad

Diseases related to Familial Mediterranean Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 977)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis31.6SAA2, SAA4, SAA1, TNFRSF1A, CRP, MEFV
2amyloidosis, renal31.2SAA2, SAA4, SAA1, MEFV
3arthritis31.2TNFRSF1A, TNF, IL1B
4rheumatic disease31.0MEFV, CRP, TNF
5amyloidosis, secondary30.8MEFV, CRP, SAA1, SAA4, SAA2
6systemic lupus erythematosus30.8NOD2, CRP, HLA-A, TNF, TNFRSF1A
7hepatitis c30.7HLA-A
8vasculitis30.7MEFV, CRP, TNF
9erysipelas30.7MEFV
10kawasaki disease30.6CRP
11spondylitis30.6NOD2
12ankylosing spondylitis30.6NOD2, CRP, TNF, TNFRSF1A
13celiac disease30.6HLA-A
14measles30.6HLA-A
15atherosclerosis30.5SAA4, SAA1, TNF, CRP, IL1B, NOD2
16tuberculosis30.5TNFRSF1A, TNF, HLA-A, CRP, IL1B, NOD2
17crohn's disease30.4NOD2, CRP, TNF
18septic arthritis30.4CRP
19adult-onset still's disease30.4CRP
20appendicitis30.4CRP
21ulcerative colitis30.4CASP1, TNF, CRP, IL1B, NOD2
22leukopenia30.4CRP
23acute leukemia30.3CASP1
24sepsis30.3CASP1, SAA4, TNFRSF1A, TNF, CRP, IL1B
25tumor necrosis factor receptor-associated periodic syndrome30.3MVK, TNFRSF1A, TNF, MEFV
26mevalonic aciduria30.3MVK
27palindromic rheumatism30.2MEFV
28alzheimer's disease30.2CASP1, SAA4, TNFRSF1A, DBH, IL1B, GSN
29psoriatic arthritis30.2CRP, TNF
30asthma30.2TNF, IL1B, NOD2, GSN
31fabry disease30.2DBH
32synovitis30.2TNFRSF1A, TNF, CRP, IL1B
33amyloid tumor30.2SAA2, SAA4, GSN
34poems syndrome30.2IL1B
35osteoarthritis30.2SAA1, TNFRSF1A, TNF, CRP, IL1B
36rheumatic fever30.2CRP
37acute pancreatitis30.2CRP, CASP1
38familial cold autoinflammatory syndrome30.2NLRP3, CASP1, TNFRSF1A, MEFV, IL1B
39uveitis30.2NOD2, HLA-A, TNF, TNFRSF1A
40septic shock30.2IL1B, CRP, TNF, TNFRSF1A, CASP1
41vaccinia30.1HLA-A
42hyper-igd syndrome30.1MVK
43urticaria30.1CASP1, NLRP3
44hepatitis b30.1TNFRSF1A, HLA-A
45viral hepatitis30.1TNFRSF1A
46muckle-wells syndrome30.0NLRP3, CASP1, TNFRSF1A, MEFV, IL1B
47vascular disease30.0IL1B, TNF, TNFRSF1A
48chorioamnionitis30.0IL1B, CRP, TNF
49aortic aneurysm29.9CRP
50chronic infantile neurological cutaneous articular syndrome29.8NLRP3, CASP1, MVK, TNFRSF1A, MEFV, IL1B

Graphical network of the top 20 diseases related to Familial Mediterranean Fever:



Diseases related to familial mediterranean fever

Clinical Features for Familial Mediterranean Fever

Sources:
47OMIM
See all sources

Clinical features from OMIM:

249100

Drugs & Therapeutics for Familial Mediterranean Fever

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Familial Mediterranean Fever

Drug clinical trials:

Search ClinicalTrials for Familial Mediterranean Fever

Search NIH Clinical Center for Familial Mediterranean Fever

Search CenterWatch for Familial Mediterranean Fever

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Familial Mediterranean Fever

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Familial Mediterranean Fever:

id Genetic test Affiliating Genes
1 Familial Mediterranean Fever20 22 MEFV

Anatomical Context for Familial Mediterranean Fever

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Familial Mediterranean Fever:

33
Bone marrow, Brain, Heart, Small intestine, Colon, Kidney, Liver, Lung, Thyroid, Adrenal gland, Breast, Skin, Monocytes, T cells, Endothelial

Animal Models for Familial Mediterranean Fever or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Familial Mediterranean Fever:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.5GSN, DBH, MEFV, CASP1, NLRP3
2MP:000538710.4GSN, PYCARD, NLRP3, CASP1, TNFRSF1A, TNF
3MP:000537610.2TNFRSF1A, SAA1, CASP1, NLRP3, PYCARD, TNF

Publications for Familial Mediterranean Fever

Sources:
51PubMed
See all sources

Articles related to Familial Mediterranean Fever:

(show top 50)    (show all 723)
idTitleAuthorsYear
1
Decreased vitamin D levels in children with familial Mediterranean fever. (24410734)
2014
2
Increased levels of macrophage migration inhibitory factor in patients with familial mediterranean Fever. (23794947)
2013
3
Familial Mediterranean fever in heterozygotes: are we able to accurately diagnose the disease in very young children? (23508419)
2013
4
Amyloidosis and its related factors in Turkish patients with familial Mediterranean fever: a multicentre study. (24369413)
2013
5
Paraoxonase 1 and arylesterase levels in children with familial Mediterranean fever. (23426541)
2013
6
Long chain fatty acid (Lcfa) abnormalities in hyper Igd syndrome (Hids) and Familial Mediterranean Fever (Fmf): new insight into heritable periodic fevers. (23375471)
2013
7
Analysis of cytotoxic T lymphocyte antigen-4 (CTLA-4) promoter -318C/T and +49A/G gene polymorphisms in Turkish patients with familial Mediterranean fever. (22923220)
2013
8
Familial Mediterranean FeVer gene (MEFV) mutations as a modifier of systemic lupus erythematosus. (22532615)
2012
9
QT variability in amyloidosis of familial Mediterranean fever. (22675838)
2012
10
Familial Mediterranean fever: risk factors, causes of death, and prognosis in the colchicine era. (22543627)
2012
11
The effect of regular colchicine treatment on biomarkers related with vascular injury in newly diagnosed patients with familial Mediterranean fever. (22258906)
2012
12
Genetic analysis of C5a receptors in neutrophils from patients with familial Mediterranean fever. (22187344)
2012
13
Coexistence of familial Mediterranean fever and rheumatoid arthritis. (23053718)
2012
14
Leucopenia resoluted with colchicine in familial mediterranean Fever. (22031120)
2012
15
Therapeutic approach to patients with familial Mediterranean fever-related amyloidosis resistant to colchicine. (23010471)
2012
16
Plasma ghrelin levels in patients with familial Mediterranean fever. (22297653)
2012
17
A case of Takayasu's arteritis associated with familial Mediterranean fever. (22935091)
2012
18
Coexistence of vasculitides with familial Mediterranean fever. (21547384)
2011
19
Current data on familial Mediterranean fever. (21074474)
2011
20
Evidence for the involvement of mTOR inhibition and basal autophagy in familial Mediterranean fever phenotype. (21081147)
2011
21
MEFV heterogeneity in Turkish Familial Mediterranean Fever patients. (19714479)
2010
22
A case of familial Mediterranean fever associated with compound heterozygosity for the pyrin variant L110P-E148Q/M680I in Japan. (19967574)
2010
23
Genotype-phenotype correlation in patients with familial Mediterranean fever in East Anatolia (Turkey). (20373849)
2010
24
The effect of colchicine on physical growth in children with familial mediterranean fever. (20016916)
2010
25
Familial Mediterranean fever in children presenting with attacks of fever alone. (20194447)
2010
26
Does breast-feeding affect severity of familial Mediterranean fever? (19688293)
2009
27
Diffusion-weighted MRI of the kidneys in patients with familial Mediterranean fever: initial experience. (19813167)
2009
28
The clinical and genetical features of 124 children with Familial Mediterranean fever: experience of a single tertiary center. (19115056)
2009
29
The effect of plasminogen activator inhibitor-1 -675 4G/5G polymorphism on familial Mediterranean fever (FMF) disease. (19033264)
2009
30
Distribution of killer cell immunoglobulin-like receptor (KIR) genotypes in patients with familial Mediterranean fever. (19309280)
2009
31
Expression of the familial Mediterranean fever gene is regulated by nonsense-mediated decay. (19755381)
2009
32
Familial Mediterranean fever and IgA nephropathy: case report and review of the literature. (18793551)
2008
33
Heightened endotoxin susceptibility of monocytes and neutrophils during familial Mediterranean fever. (18294193)
2008
34
Development of interferon induced sarcoidosis in a patient with familial mediterranean fever. (18932035)
2008
35
Familial Mediterranean fever gene and protection against asthma. (18219832)
2007
36
Serum proinflammatory cytokines directing T helper 1 polarization in patients with familial Mediterranean fever. (17225924)
2007
37
Protracted familial mediterranean fever arthritis presenting as septic arthritis. (17387477)
2007
38
Juvenile psoriatic arthritis carrying familial Mediterranean fever gene mutations in a 14-year-old Turkish girl. (17408446)
2007
39
Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. (16403826)
2006
40
Spontaneous renal laceration as the presenting feature of polyarteritis nodosa in a patient with familial Mediterranean fever after hepatitis A infection. (15765217)
2005
41
Comparison of synovial MMP-1 and TIMP-1 levels in patients with various inflammatory arthritides: is there any difference between rheumatoid arthritis, BehAset's disease and familial Mediterranean fever? (12447637)
2002
42
Reduced MEFV messenger RNA expression in patients with familial Mediterranean fever. (12384939)
2002
43
The spectrum of familial mediterranean fever (FMF) mutations. (11464238)
2001
44
MEFV mutation analysis in patients suffering from amyloidosis of familial Mediterranean fever. (10211405)
1999
45
Genotypic diagnosis of familial Mediterranean fever (FMF) using new microsatellite markers: example of two extensive non-Ashkenazi Jewish pedigrees. (9152834)
1997
46
Construction of a 1-Mb restriction-mapped cosmid contig containing the candidate region for the familial Mediterranean fever locus (MEFV) on chromosome 16p 13.3. (9177779)
1997
47
Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)
1995
48
Serum concentration and urinary excretion of beta 2-microglobulin and microalbuminuria in familial Mediterranean fever. (8110003)
1994
49
Whipple's disease, familial Mediterranean fever, and adult-onset Still's disease. (1698427)
1990
50
Unmasking of isolated hypoaldosteronism after renal allotransplantation in familial Mediterranean fever. (7045036)
1982

Genetic Variations for Familial Mediterranean Fever

Expression for genes affiliated with Familial Mediterranean Fever

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Familial Mediterranean Fever

Search GEO for disease gene expression data for Familial Mediterranean Fever.

Pathways for genes affiliated with Familial Mediterranean Fever

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 53R&D Systems, 12EMD Millipore, 52QIAGEN, 56SinoBiological, 4Cell Signaling Technology
See all sources

Pathways related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5PSTPIP1, IL1B, PYCARD, NLRP3, CASP1, SAA1
2
Hide members
10.5IL1B, PSTPIP1, MEFV, NOD2, CASP1, NLRP3
3
Hide members
10.5CASP1, NLRP3, PYCARD, PSTPIP1, MEFV
410.5SAA1, SAA2, SAA4, TNF, CRP, IL1B
510.5SAA1, SAA4, SAA2
6
Hide members
10.5NOD2, IL1B, TNF, CASP1, NLRP3, PYCARD
7
Apoptosis and survival Caspase cascade
Hide members
10.5GSN, CASP1, TNFRSF1A, TNF
8
Hide members
10.5TNFRSF1A, PYCARD, NLRP3, CASP1, TNF, HLA-A
9
Hide members
10.5CASP1, TNFRSF1A, TNF
10
Hide members
10.5TNFRSF1A, CASP1, TNF
1110.5NLRP3, IL1B, TNF, CASP1, PYCARD
12
Hide members
10.5HLA-A, TNFRSF1A, CASP1, TNF
13
Hide members
10.5IL1B, CASP1, NOD2
14
Hide members
10.5TNF, IL1B, TNFRSF1A, CASP1
15
Hide members
10.5TNF, TNFRSF1A, CASP1, IL1B
16
Hide members
10.5CASP1, TNF, IL1B, TNFRSF1A
17
Hide members
10.5CASP1, HLA-A, IL1B, NOD2
1810.5IL1B, CASP1
1910.5CASP1, IL1B, TNF
2010.5NOD2, TNFRSF1A, TNF
2110.5DBH
2210.5PYCARD, CASP1
2310.5CASP1, PYCARD
24
Hide members
10.5NOD2
2510.5TNFRSF1A, TNF, NOD2, IL1B
2610.5TNFRSF1A, TNF, NOD2, IL1B
2710.5TNF, IL1B, CASP1, PYCARD
2810.5IL1B, CASP1, PYCARD
29
Hide members
10.5TNF, TNFRSF1A
3010.5TNF, TNFRSF1A, IL1B
31
Hide members
10.5TNFRSF1A, IL1B, HLA-A, TNF
3210.5TNFRSF1A, PYCARD, TNF, IL1B

Compounds for genes affiliated with Familial Mediterranean Fever

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1endotoxin4511.0GSN, MEFV, TNFRSF1A, SAA1, SAA4, CASP1
2mevalonate4511.0NLRP3, CASP1, MVK, TNFRSF1A, MEFV
3anakinra45 1112.0NLRP3, CASP1, MVK, TNF, CRP, IL1B
4dexamethasone45 50 29 1113.9DBH, SAA1, SAA2, CASP1
5lipid4510.9CASP1, MVK, SAA4, SAA1, TNFRSF1A, TNF
6tenidap45 2911.9SAA1
7infliximab45 50 1112.9TNFRSF1A, TNF, CRP, IL1B, NOD2
8simvastatin45 50 60 29 11 2415.9MVK, SAA1, TNFRSF1A, TNF, CRP
9neopterin4510.9SAA4, TNFRSF1A, TNF, CRP, IL1B
10etanercept45 50 1112.9TNFRSF1A, TNF, CRP, IL1B
11muramyl dipeptide45 2911.9NOD2, IL1B, CASP1
12leflunomide50 45 1112.9SAA4, TNFRSF1A, TNF, IL1B
13peptidoglycan45 2911.9CASP1, TNF, IL1B, NOD2
14alanine4510.9MVK, SAA1, TNFRSF1A, HLA-A, CRP, DBH
15methotrexate45 50 1112.9NLRP3, TNFRSF1A, TNF, CRP, IL1B
16ivig4510.9TNFRSF1A, TNF, CRP, IL1B
17superoxide45 2411.9CASP1, TNFRSF1A, TNF, DBH, IL1B, GSN
18actinomycin4510.9IL1B, TNFRSF1A
19anisomycin45 1111.9CASP1, TNFRSF1A, TNF, IL1B
20n acetylcysteine4510.9CASP1, TNFRSF1A, TNF, CRP, IL1B
21sb 20358045 6011.9CASP1, TNFRSF1A, TNF, CRP, IL1B
22staurosporin4510.9IL1B, TNF, CASP1
23tpck4510.9CASP1, TNF, IL1B
24acetyl-tyr-val-ala-asp-cho4510.9IL1B, CASP1
25cuprophan4510.9IL1B, TNFRSF1A, CASP1
26fibrinogen4510.9SAA4, SAA1, TNF, CRP, GSN
27glucose4510.8SAA4, SAA1, DBH, GSN
28okt34510.8CRP, TNF, TNFRSF1A
29sulfasalazine45 29 50 1113.8TNF, CRP, IL1B
308-isoprostane4510.8CRP, TNF, SAA4
31ns 39845 6011.8TNFRSF1A, TNF, IL1B
32turpentine4510.8CRP, IL1B
33hypericin4510.8CASP1, DBH
34tocilizumab45 1111.8TNF, CRP
35serine4510.8CASP1, MVK, TNFRSF1A, TNF, PSTPIP1, DBH
36fmlp4510.8GSN
37prostacyclin4510.8TNFRSF1A, TNF, CRP, IL1B
38poly(i-c)4510.8IL1B, TNF, CASP1
39il 104510.7NOD2, IL1B, TNF
40pge24510.7DBH
41calcium45 50 11 2413.7CASP1, SAA4, SAA1, TNFRSF1A, HLA-A, CRP
42diphenyleneiodonium4510.7IL1B, TNF, CASP1
43cdp5714510.7CRP, TNF
44nitric oxide45 11 2412.6CASP1, TNFRSF1A, TNF, DBH, IL1B, NOD2
45pentoxifylline45 1111.6CASP1
46creatinine4510.6CASP1, MVK, SAA4, TNFRSF1A, CRP
47oxygen45 2411.5TNFRSF1A, TNF, DBH, GSN, CASP1
48c2ceramide4510.5TNFRSF1A, TNF, IL1B
49bucillamine4510.4IL1B, CRP
50tlck4510.2IL1B, CASP1

GO Terms for genes affiliated with Familial Mediterranean Fever

Sources:
16Gene Ontology
See all sources

Cellular components related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6GSN, PYCARD, CASP1, SAA4, SAA1, TNFRSF1A
2NLRP3 inflammasome complexGO:07255910.6CASP1, NLRP3, PYCARD
3cytosolGO:00582910.5GSN, NOD2, IL1B, MEFV, NLRP3, MVK
4high-density lipoprotein particleGO:03436410.5SAA2, SAA4, SAA1
5AIM2 inflammasome complexGO:09716910.4CASP1, PYCARD
6NLRP1 inflammasome complexGO:07255810.2PYCARD, CASP1

Biological processes related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:05072810.9NLRP3, MVK, SAA1, TNFRSF1A, MEFV
2nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:03587210.9NOD2, MEFV, PSTPIP1, CASP1, NLRP3, PYCARD
3positive regulation of interleukin-1 beta secretionGO:05071810.9NOD2, CASP1, NLRP3, PYCARD
4inflammatory responseGO:00695410.9PYCARD, NLRP3, TNFRSF1A, TNF, CRP, MEFV
5innate immune responseGO:04508710.9PYCARD, NLRP3, CASP1, SAA1, PSTPIP1, MEFV
6acute-phase responseGO:00695310.9SAA2, SAA4, SAA1, CRP
7interleukin-1 beta productionGO:03261110.9IL1B, CASP1, PYCARD
8positive regulation of NF-kappaB transcription factor activityGO:05109210.9PYCARD, NLRP3, TNF, IL1B, NOD2
9positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.9CASP1, TNFRSF1A, TNF, IL1B, NOD2
10positive regulation of interleukin-6 productionGO:03275510.9NOD2, IL1B, TNF, PYCARD
11apoptotic processGO:00691510.9PYCARD, NLRP3, CASP1, TNFRSF1A, TNF, IL1B
12positive regulation of JNK cascadeGO:04633010.9PYCARD, TNF, IL1B, NOD2
13activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.9PYCARD, NLRP3, CASP1, TNF
14positive regulation of tumor necrosis factor productionGO:03276010.8NOD2, TNFRSF1A, PYCARD
15positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328010.8PYCARD, NLRP3, TNF
16defense response to Gram-positive bacteriumGO:05083010.8TNF, CRP, NOD2
17positive regulation of interferon-gamma productionGO:03272910.8PYCARD, TNF, IL1B
18positive regulation of calcidiol 1-monooxygenase activityGO:06055910.8TNF, IL1B
19detection of biotic stimulusGO:00959510.8NLRP3, NOD2
20sequestering of triglycerideGO:03073010.8TNF, IL1B
21response to hypoxiaGO:00166610.8CASP1, TNFRSF1A, TNF, CRP
22positive regulation of heterotypic cell-cell adhesionGO:03411610.8IL1B, TNF
23positive regulation of cysteine-type endopeptidase activityGO:200105610.8MEFV, PYCARD
24positive regulation of fever generationGO:03162210.8IL1B, TNF
25cellular response to mechanical stimulusGO:07126010.8CASP1, TNFRSF1A, IL1B
26positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.7NOD2, TNF
27negative regulation of NF-kappaB transcription factor activityGO:03208810.7NOD2, NLRP3, PYCARD
28negative regulation of lipid storageGO:01088810.7TNF, CRP
29positive regulation of chemokine biosynthetic processGO:04508010.7IL1B, TNF
30positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.6IL1B, TNF, PYCARD
31response to ethanolGO:04547110.6TNFRSF1A, CRP, GSN
32regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.6IL1B, TNF
33negative regulation of interleukin-12 productionGO:03269510.6NOD2, MEFV
34activation of MAPK activityGO:00018710.5TNF, IL1B, NOD2
35negative regulation of lipid catabolic processGO:05099510.5IL1B, TNF
36positive regulation of ERK1 and ERK2 cascadeGO:07037410.4NOD2, TNF, PYCARD
37positive regulation of membrane protein ectodomain proteolysisGO:05104410.2IL1B, TNF

Molecular functions related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:04283410.5NOD2, NLRP3
2cysteine-type endopeptidase activityGO:00419710.2CASP1, CASP16, PYCARD

Products for genes affiliated with Familial Mediterranean Fever

  • Antibodies
  • Proteins
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  • Antibodies

Sources for Familial Mediterranean Fever

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet