FMF
MCID: FML018
MIFTS: 74

Familial Mediterranean Fever (FMF) malady

Genetic diseases, Rare diseases, Immune diseases, Nephrological diseases, Bone diseases, Blood diseases categories
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Summaries for Familial Mediterranean Fever

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21Genetics Home Reference, 43NIH Rare Diseases, 34MedlinePlus, 65Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
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MedlinePlus:34 A fever is a body temperature that is higher than normal. it is not an illness. it is part of your body's defense against infection. most bacteria and viruses that cause infections do well at the body's normal temperature (98.6 f). a slight fever can make it harder for them to survive. fever also activates your body's immune system. infections cause most fevers. there can be many other causes, including medicines heat exhaustion cancers autoimmune diseases treatment depends on the cause of your fever. your health care provider may recommend using over-the-counter medicines such as acetaminophen or ibuprofen to lower a very high fever. adults can also take aspirin, but children with fevers should not take aspirin. it is also important to drink enough liquids to prevent dehydration.

MalaCards: Familial Mediterranean Fever, also known as benign paroxysmal peritonitis, is related to relapsing fever and amyloidosis. An important gene associated with Familial Mediterranean Fever is MEFV (Mediterranean fever), and among its related pathways are Folate Metabolism and Amyotrophic lateral sclerosis (ALS). The drug colchicine and the compounds tenidap and geranylgeraniol have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and thyroid, and related mouse phenotypes are integument and hematopoietic system.

Genetics Home Reference:21 Familial Mediterranean fever is an inherited condition characterized by recurrent episodes of painful inflammation in the abdomen, chest, or joints. These episodes are often accompanied by fever and sometimes a rash or headache. Occasionally inflammation may occur in other parts of the body, such as the heart; the membrane surrounding the brain and spinal cord; and in males, the testicles. In about half of affected individuals, attacks are preceded by mild signs and symptoms known as a prodrome. Prodromal symptoms include mildly uncomfortable sensations in the area that will later become inflamed, or more general feelings of discomfort.

NIH Rare Diseases:43 Familial mediterranean fever (fmf) is an inherited condition characterized by episodes of painful inflammation of the abdominal lining (peritonitis),  lining surrounding the lungs (pleurisy), and joints (arthralgia and occasionally arthritis). these episodes are often accompanied by fever and sometimes a characteristic ankle rash. the first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. between attacks, people often do not have any symptoms. without treatment, fmf can lead to kidney failure due to a buildup of certain protein deposits (amyloidosis). fmf is usually inherited in an autosomal recessive fashion and is caused by mutations in the mefv gene. last updated: 6/29/2012

Wikipedia:65 Familial Mediterranean fever (FMF), is a hereditary inflammatory disorder. FMF is an autoinflammatory... more...

Description from OMIM:47 249100

GeneReviews summary for fmf

Aliases & Classifications for Familial Mediterranean Fever

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8Disease Ontology, 65Wikipedia, 19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 47OMIM, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

familial mediterranean fever 8 19 43 21 10 45 62
benign paroxysmal peritonitis 8 65 43 21
recurrent polyserositis 65 19 43 21
familial paroxysmal polyserositis 65 43 21
mediterranean fever, familial 65 20 22
fmf 65 43 21
wolff periodic disease 65 21
periodic peritonitis 65 43
periodic disease 65 43
periodic fever 43 62
fever 65 34
hereditary autoinflammatory diseases 62
hereditary periodic fever syndromes 45
hereditary periodic fever syndrome 65
siegal-cattan-mamou disease 21
reimann periodic disease 21
mef 21


External Ids:

Disease Ontology8 DOID:2987
OMIM47 249100
NCIt40 C84707
SNOMED-CT58 12579009
ICD9CM27 277.31
MeSH35 D010505
ICD1025 R50.8, R50.9

Related Diseases for Familial Mediterranean Fever

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17GeneCards, 18GeneDecks
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Diseases in the Familial Mediterranean Fever family:

Familial Mediterranean Fever Type 1 Familial Mediterranean Fever Type 2
Familial Mediterranean Fever, Ar Familial Mediterranean Fever, Ad

Diseases related to Familial Mediterranean Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1057)
idRelated DiseaseScoreTop Affiliating Genes
1relapsing fever31.6TNFRSF1A, MEFV, MVK
2amyloidosis31.4TNFRSF1A, DBH, SAA2, SAA1, MEFV, CRP
3polyarteritis nodosa31.2MEFV
4arthritis30.8NLRP3, CRP, CASP1, MVK, MEFV, PSTPIP1
5spondylitis30.8NOD2
6brucellosis30.8SAA1, MEFV
7crohn's disease30.7NOD2, CRP
8systemic lupus erythematosus30.7TNFRSF1A, CRP, NOD2
9peritonitis30.6CRP, MEFV
10pericarditis30.6MEFV
11ankylosing spondylitis30.6TNFRSF1A, CRP, NOD2
12septic arthritis30.6CRP
13periodic fever, familial, autosomal dominant30.6TNFRSF1A, MEFV, MVK
14adult-onset still's disease30.6CRP
15rheumatoid arthritis30.6TNFRSF1A, SAA2, SAA1, MEFV, CASP1, CRP
16inflammatory bowel disease30.5TNFRSF1A
17amyloidosis, secondary30.5SAA2, SAA1, MEFV, CRP
18tuberculosis30.5NOD2, CRP, TNFRSF1A
19ulcerative colitis30.4NOD2, CRP
20palindromic rheumatism30.4MEFV
21hyper-igd syndrome30.4MVK
22psoriatic arthritis30.4CRP
23amyloidosis, renal30.3SAA2, SAA1, MEFV
24myocardial infarction30.3SAA1, CASP1, CRP
25conjunctivitis30.2TNFRSF1A, NLRP3
26synovitis30.2CRP, TNFRSF1A
27sepsis30.2TNFRSF1A, CASP1, CRP, NOD2
28osteoarthritis30.2TNFRSF1A, SAA1, CRP
29acute pancreatitis30.2CRP, CASP1
30septic shock30.2CRP, CASP1, TNFRSF1A
31exanthem30.2NLRP3, CRP
32psoriasis30.2TNFRSF1A, CASP1, NOD2
33uveitis30.2NOD2, TNFRSF1A
34urticaria30.1NLRP3, CASP1
35familial cold autoinflammatory syndrome30.0TNFRSF1A, MEFV, CASP1, NLRP3
36muckle-wells syndrome30.0NLRP3, CASP1, MEFV, TNFRSF1A
37acute myocardial infarction29.9CRP, MEFV, SAA1
38bronchitis29.9NOD2, CASP1, SAA1
39behcet's disease29.8CRP, MEFV
40arthropathy29.7CRP, NLRP3, NOD2
41chronic infantile neurological cutaneous articular syndrome29.7TNFRSF1A, MEFV, MVK, CASP1, NLRP3
42rheumatic disease29.6CRP, MEFV
43blau syndrome29.4MEFV, MVK, NLRP3, NOD2
44pyoderma gangrenosum29.4PSTPIP1, MEFV, MVK, NLRP3, NOD2
45hemorrhagic fever11.3
46spotted fever11.2
47typhoid fever11.1
48q fever11.1
49yellow fever11.1
50rift valley fever11.0

Graphical network of the top 20 diseases related to Familial Mediterranean Fever:



Diseases related to familial mediterranean fever

Symptoms for Familial Mediterranean Fever

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47OMIM
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Clinical features from OMIM:

249100

Drugs & Therapeutics for Familial Mediterranean Fever

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Familial Mediterranean Fever

Search NIH Clinical Center for Familial Mediterranean Fever

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Familial Mediterranean Fever

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20GeneTests, 22GTR
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Genetic tests related to Familial Mediterranean Fever:

id Genetic test Affiliating Genes
1 Familial Mediterranean Fever20 22 MEFV

Anatomical Context for Familial Mediterranean Fever

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33MalaCards
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MalaCards organs/tissues related to Familial Mediterranean Fever:

33
Kidney, Lung, Thyroid, Bone, Testes, Endothelial, Liver, Heart, Bone marrow, Skin, Colon, Brain, Breast, Monocytes, T cells

Animal Models for Familial Mediterranean Fever or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Familial Mediterranean Fever:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.3NLRP3, CASP1, MEFV, DBH, TNFRSF1A
2MP:00053977.6TNFRSF1A, PSTPIP1, MEFV, CASP1, NLRP3, NOD2
3MP:00053907.6TNFRSF1A, DBH, MEFV, NLRP3, NOD2
4MP:00053877.2TNFRSF1A, PSTPIP1, MEFV, CASP1, CRP, NLRP3
5MP:00053766.8NOD2, TNFRSF1A, DBH, SAA1, MEFV, CASP1

Publications for Familial Mediterranean Fever

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52PubMed
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Articles related to Familial Mediterranean Fever:

(show top 50)    (show all 717)
idTitleAuthorsYear
1
Quality of life in adult patients with Familial Mediterranean fever living in Germany or Turkey compared to healthy subjects: a study evaluating the effect of disease severity and country of residence. (23274441)
2013
2
Thyroid autoimmunity in patients with Familial Mediterranean Fever: preliminary results. (24302182)
2013
3
The kidney in familial Mediterranean fever. (24293619)
2013
4
The risk of familial Mediterranean fever in MEFV heterozygotes: a statistical approach. (23844200)
2013
5
Management of familial Mediterranean fever by colchicine does not normalize the altered profile of microbial long chain fatty acids in the human metabolome. (23373011)
2013
6
A very rare cause of pleuritic chest pain: bilateral pleuritis as a first sign of familial mediterranean Fever. (23401829)
2013
7
Misdiagnosis of familial Mediterranean fever in patients with Anderson-Fabry disease. (22905681)
2013
8
Infliximab therapy for familial Mediterranean fever-related amyloidosis: case series with long term follow-up. (22673790)
2012
9
Familial Mediterranean FeVer gene (MEFV) mutations as a modifier of systemic lupus erythematosus. (22532615)
2012
10
The expanded clinical profile and the efficacy of colchicine therapy in Egyptian children suffering from familial Mediterranean fever: a descriptive study. (23206577)
2012
11
The possible underlying pathophysiological mechanisms for development of multiple sclerosis in familial Mediterranean fever. (22406096)
2012
12
Myalgia as a symptom of familial Mediterranean fever in children. (22020390)
2012
13
Down-regulation of adiponectin in patients with familial Mediterranean fever during attack-free period. (21877244)
2012
14
QT variability in amyloidosis of familial Mediterranean fever. (22675838)
2012
15
Familial Mediterranean fever with a single MEFV mutation: can a deletion resulting in I+-thalassemia be the cause? (21179105)
2011
16
Colchicine and ocular surface changes in familial Mediterranean fever. (19681787)
2010
17
Familial Mediterranean fever in Iranian children. First report from Iran. (20483055)
2010
18
Protracted febrile myalgia in two children with familial Mediterranean fever. (20723111)
2010
19
Protracted synovitis without systemic manifestations in familial Mediterranean fever (FMF). (20868584)
2010
20
A rare presentation of familial mediterranean Fever; acute scrotum and hydrocele amyloidosis. (23056732)
2010
21
Neuroendocrine immune system in familial Mediterranean fever. (21428190)
2010
22
Does breast-feeding affect severity of familial Mediterranean fever? (19688293)
2009
23
Skin and muscle involvement as presenting symptoms in four children with familial Mediterranean fever. (19240979)
2009
24
The role of inflammatory cytokines and NF-kappaB/MAPK signaling pathways in the evolution of familial Mediterranean fever: current clinical perspectives and potential therapeutic approaches. (19733345)
2009
25
Plasma ghrelin levels in patients with Familial Mediterranean Fever. (19601914)
2009
26
Familial Mediterranean fever and IgA nephropathy: case report and review of the literature. (18793551)
2008
27
Assessment of aortic wall stiffness in patients with Familial Mediterranean Fever. (18375166)
2008
28
MEFV gene 3'-UTR Alu repeat polymorphisms in patients with familial Mediterranean fever. (19026119)
2008
29
Familial Mediterranean fever. Rare manifestation without fever and with inconspicuous family case history]. (18651363)
2008
30
Heightened endotoxin susceptibility of monocytes and neutrophils during familial Mediterranean fever. (18294193)
2008
31
Familial Mediterranean fever in three Japanese patients, and a comparison of the frequency of MEFV gene mutations in Japanese and Mediterranean populations. (18097735)
2008
32
The familial Mediterranean fever (MEFV) gene may be a modifier factor of inflammatory bowel disease in infancy. (17520284)
2008
33
Analysis of familial Mediterranean fever gene mutations in 202 patients with familial Mediterranean fever. (18662100)
2008
34
Anakinra: new therapeutic approach in children with Familial Mediterranean Fever resistant to colchicine. (18541452)
2008
35
Possible correlation between reversible and irreversible lesions in familial Mediterranean fever, soluble Fas, and C5a inhibitor activity: comment on the letter by Yasui and Yamazaki. (18512795)
2008
36
Country as the primary risk factor for renal amyloidosis in familial Mediterranean fever. (17469185)
2007
37
MEFV mutations in Tunisian patients suffering from familial Mediterranean fever. (17276496)
2007
38
ABCC6 is unlikely to be a modifier gene for familial Mediterranean fever severity. (18305351)
2007
39
Arg753Gln TLR-2 polymorphism in familial mediterranean fever: linking the environment to the phenotype in a monogenic inflammatory disease. (17013994)
2006
40
Successful pregnancies in dialysis patients including those suffering from cystinosis and familial Mediterranean fever. (17136701)
2006
41
Familial Mediterranean fever in the Syrian population: gene mutation frequencies, carrier rates and phenotype-genotype correlation. (16627024)
2006
42
Increased frequency of mutations in the gene responsible for familial Mediterranean fever (MEFV) in a cohort of patients with ulcerative colitis: evidence for a potential disease-modifying effect? (16614989)
2006
43
MEFV mutations in familial Mediterranean fever: association of M694V homozygosity with arthritis. (14727057)
2005
44
Sacroiliitis in familial Mediterranean fever and seronegative spondyloarthropathy: importance of differential diagnosis. (15711787)
2005
45
Genetic risk factors of amyloidogenesis in familial Mediterranean fever. (16118480)
2005
46
Role of A-SAA in monitoring subclinical inflammation and in colchicine dosage in familial Mediterranean fever. (12942707)
2003
47
A case of osteopoikilosis coexisting with amyloidosis of familial Mediterranean fever. (14586673)
2003
48
Familial Mediterranean fever (FMF) and renal AA amyloidosis--phenotype-genotype correlation, treatment and prognosis. (12832747)
2003
49
Familial Mediterranean fever: report of a case]. (11211479)
2000
50
Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)
1995

Variations for Familial Mediterranean Fever

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Familial Mediterranean Fever:

1 (show all 17)
id Gene Name Type Significance SNP ID Assembly Location
1MEFVNM_000243.2(MEFV): c.2080A> G (p.Met694Val)single nucleotide variantPathogenicrs61752717GRCh37Chr 16, 3293407: 3293407
2MEFVNM_000243.2(MEFV): c.2082G> A (p.Met694Ile)single nucleotide variantPathogenicrs28940578GRCh37Chr 16, 3293405: 3293405
3MEFVNM_000243.2(MEFV): c.2177T> C (p.Val726Ala)single nucleotide variantPathogenicrs28940579GRCh37Chr 16, 3293310: 3293310
4MEFVNM_000243.2(MEFV): c.442G> C (p.Glu148Gln)single nucleotide variantPathogenic, Uncertain significancers3743930GRCh37Chr 16, 3304626: 3304626
5MEFVNM_000243.2(MEFV): c.501G> C (p.Glu167Asp)single nucleotide variantPathogenicrs104895079GRCh37Chr 16, 3304567: 3304567
6MEFVNM_000243.2(MEFV): c.800C> T (p.Thr267Ile)single nucleotide variantPathogenicrs104895081GRCh37Chr 16, 3304268: 3304268
7MEFVNM_000243.2(MEFV): c.1437C> G (p.Phe479Leu)single nucleotide variantPathogenicrs104895083GRCh37Chr 16, 3297166: 3297166
8MEFVNM_000243.2(MEFV): c.2074_2076delATA (p.Ile692del)deletionPathogenicrs121907890GRCh37Chr 16, 3293411: 3293413
9MEFVNM_000243.2(MEFV): c.2084A> G (p.Lys695Arg)single nucleotide variantPathogenicrs104895094GRCh37Chr 16, 3293403: 3293403
10MEFVNM_000243.2(MEFV): c.2230G> T (p.Ala744Ser)single nucleotide variantPathogenic, Uncertain significancers61732874GRCh37Chr 16, 3293257: 3293257
11MEFVNM_000243.2(MEFV): c.2282G> A (p.Arg761His)single nucleotide variantPathogenicrs104895097GRCh37Chr 16, 3293205: 3293205
12MEFVNM_000243.2(MEFV): c.2040G> A (p.Met680Ile)single nucleotide variantPathogenicrs28940580GRCh37Chr 16, 3293447: 3293447
13MEFVNM_000243.2(MEFV): c.1958G> A (p.Arg653His)single nucleotide variantPathogenicrs104895085GRCh37Chr 16, 3293529: 3293529
14MEFVNM_000243.2(MEFV): c.443A> T (p.Glu148Val)single nucleotide variantLikely pathogenic, Pathogenicrs104895076GRCh37Chr 16, 3304625: 3304625
15MEFVNM_000243.2(MEFV): c.2082G> A (p.Met694Ile)single nucleotide variantPathogenicrs28940578GRCh37Chr 16, 3293405: 3293405
16MEFVNM_000243.2(MEFV): c.1432C> T (p.His478Tyr)single nucleotide variantPathogenicrs104895105GRCh37Chr 16, 3297171: 3297171
17MEFVNM_000243.2(MEFV): c.2040G> C (p.Met680Ile)single nucleotide variantPathogenicrs28940580GRCh37Chr 16, 3293447: 3293447

Expression for genes affiliated with Familial Mediterranean Fever

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Mediterranean Fever

Search GEO for disease gene expression data for Familial Mediterranean Fever.

Pathways for genes affiliated with Familial Mediterranean Fever

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50PathCards, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 55Reactome, 54R&D Systems, 60Thomson Reuters
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Pathways related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Vitamin B12 Metabolism38
9.9SAA1, SAA2
2
Show member pathways
Amyotrophic lateral sclerosis (ALS)38
9.6CASP1, TNFRSF1A
3
Show member pathways
thioredoxin pathway38
9.3SAA2, SAA1, CRP
4
Show member pathways
IL-1 Signaling Pathway38
IL1-mediated signaling events38
9.3NOD2, CASP1
5
Show member pathways
9.2TNFRSF1A, CASP1, NLRP3
69.1NOD2, TNFRSF1A
7
Show member pathways
9.0NOD2, CASP1, SAA1
8
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.9CASP1, NLRP3, NOD2
9
Show member pathways
8.2NOD2, NLRP3, CASP1, MEFV, PSTPIP1

Compounds for genes affiliated with Familial Mediterranean Fever

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45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 3BitterDB, 24HMDB
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Compounds related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1tenidap45 2911.0CRP, SAA1
2geranylgeraniol4510.0MVK, CASP1
3cuprophan459.9CASP1, TNFRSF1A
4hypericin459.9CASP1, DBH
5dutp459.8TNFRSF1A, CASP1
6adalimumab45 51 1111.8CRP, TNFRSF1A
7colchicine45 61 3 29 1113.8MEFV, SAA1, TNFRSF1A
8nh4cl459.8TNFRSF1A, CRP
9okt3459.7TNFRSF1A, CRP
10muramyl dipeptide45 2910.7NOD2, CASP1
11p005459.6CRP, TNFRSF1A
12etanercept45 51 1111.6TNFRSF1A, CRP
13lactulose459.5NOD2, CRP
14fluvastatin45 51 29 1112.5CRP, CASP1
15methotrexate51 45 1111.4TNFRSF1A, CRP, NLRP3
16ivig459.4TNFRSF1A, CRP
17n acetylcysteine459.4CRP, CASP1, TNFRSF1A
18peptidoglycan45 2910.3NOD2, CASP1
19sb 20358045 6110.3CRP, CASP1, TNFRSF1A
20ganciclovir45 1110.3DBH, TNFRSF1A
21histidine459.3CASP1, MVK, DBH
22phenylalanine459.2MVK, DBH, TNFRSF1A
23ethanol45 51 24 1112.2CASP1, DBH, TNFRSF1A
24anakinra45 1110.2MVK, CASP1, CRP, NLRP3
25simvastatin45 51 61 29 24 1114.1TNFRSF1A, SAA1, MVK, CRP
26norepinephrine45 24 1111.0CRP, DBH, TNFRSF1A
27cholesterol45 29 24 1112.0TNFRSF1A, SAA1, MVK, CRP
28infliximab45 51 1111.0TNFRSF1A, CRP, NOD2
29creatinine459.0CRP, CASP1, MVK, TNFRSF1A
30mevalonate458.9NLRP3, CASP1, MVK, MEFV, TNFRSF1A
31atp45 299.9NLRP3, CASP1, MVK, TNFRSF1A
32dexamethasone45 51 29 1111.8TNFRSF1A, DBH, SAA2, SAA1, CASP1
33pge2458.7CASP1, DBH, TNFRSF1A
34tyrosine458.5TNFRSF1A, DBH, PSTPIP1, MEFV, CASP1
35glucose458.5TNFRSF1A, DBH, SAA1, CASP1, CRP
36alanine458.5TNFRSF1A, DBH, SAA1, MVK, CRP
37nitric oxide45 24 1110.5NOD2, CASP1, DBH, TNFRSF1A
38threonine458.4TNFRSF1A, MVK, CASP1, NLRP3, NOD2
39oxygen45 249.3NOD2, CASP1, DBH, TNFRSF1A
40lipid458.1CRP, CASP1, MVK, SAA1, DBH, TNFRSF1A
41endotoxin458.1NOD2, CRP, CASP1, MEFV, SAA1, TNFRSF1A
42calcium45 51 24 1110.7TNFRSF1A, DBH, SAA1, CASP1, CRP, NOD2
43serine457.7TNFRSF1A, DBH, PSTPIP1, MVK, CASP1, NOD2

GO Terms for genes affiliated with Familial Mediterranean Fever

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16Gene Ontology
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Cellular components related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NLRP3 inflammasome complexGO:0725599.8NLRP3, CASP1
2high-density lipoprotein particleGO:0343649.8SAA1, SAA2
3extracellular regionGO:0055768.1CRP, CASP1, SAA1, DBH, TNFRSF1A
4cytosolGO:0058297.5PSTPIP1, MEFV, MVK, CASP1, NLRP3, NOD2

Biological processes related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1interleukin-1 beta productionGO:03261110.0NLRP3, CASP1
2acute-phase responseGO:0069539.6CRP, SAA1, SAA2
3negative regulation of interleukin-12 productionGO:0326959.6MEFV, NOD2
4cellular response to mechanical stimulusGO:0712609.6CASP1, TNFRSF1A
5detection of biotic stimulusGO:0095959.6NLRP3, NOD2
6protein oligomerizationGO:0512599.4NOD2, NLRP3
7defense response to Gram-positive bacteriumGO:0508309.3CRP, NOD2
8regulation of inflammatory responseGO:0507279.3CASP1, NOD2
9positive regulation of tumor necrosis factor productionGO:0327609.2NOD2, TNFRSF1A
10response to hypoxiaGO:0016669.2CRP, CASP1, TNFRSF1A
11positive regulation of interleukin-1 beta secretionGO:0507189.2NOD2, NLRP3, CASP1
12defense responseGO:0069529.2NOD2, NLRP3
13negative regulation of NF-kappaB transcription factor activityGO:0320889.0NOD2, NLRP3
14response to lipopolysaccharideGO:0324969.0NOD2, CASP1, TNFRSF1A
15positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.0NOD2, CASP1, TNFRSF1A
16negative regulation of inflammatory responseGO:0507288.9TNFRSF1A, SAA1, MEFV, MVK, NLRP3
17inflammatory responseGO:0069548.7TNFRSF1A, PSTPIP1, MEFV, CRP, NLRP3
18nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:0358728.6NOD2, NLRP3, CASP1, MEFV, PSTPIP1
19innate immune responseGO:0450878.3SAA1, PSTPIP1, MEFV, CASP1, NLRP3, NOD2

Molecular functions related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:0428349.3NOD2, NLRP3

Products for genes affiliated with Familial Mediterranean Fever

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Familial Mediterranean Fever

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet