FMF
MCID: FML018
MIFTS: 74

Familial Mediterranean Fever (FMF) malady

Genetic diseases category

Summaries for Familial Mediterranean Fever

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21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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MedlinePlus:33 A fever is a body temperature that is higher than normal. it is not an illness. it is part of your body's defense against infection. most bacteria and viruses that cause infections do well at the body's normal temperature (98.6 f). a slight fever can make it harder for them to survive. fever also activates your body's immune system. infections cause most fevers. there can be many other causes, including medicines heat exhaustion cancers autoimmune diseases treatment depends on the cause of your fever. your health care provider may recommend using over-the-counter medicines such as acetaminophen or ibuprofen to lower a very high fever. adults can also take aspirin, but children with fevers should not take aspirin. it is also important to drink enough liquids to prevent dehydration.

MalaCards: Familial Mediterranean Fever, also known as benign paroxysmal peritonitis, is related to amyloidosis and arthritis. An important gene associated with Familial Mediterranean Fever is MEFV (Mediterranean fever), and among its related pathways are Immune System and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drug colchicine and the compounds endotoxin and mevalonate have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and bone, and related mouse phenotypes are integument and immune system.

Genetics Home Reference:21 Familial Mediterranean fever is an inherited condition characterized by recurrent episodes of painful inflammation in the abdomen, chest, or joints. These episodes are often accompanied by fever and sometimes a rash. The first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. Typically, episodes last 12 to 72 hours and can vary in severity. The length of time between attacks is also variable. Without treatment to help prevent attacks and complications, a buildup of certain protein deposits (amyloidosis) in the body's organs and tissues may occur, which can lead to kidney failure.

NIH Rare Diseases:42 Familial mediterranean fever (fmf) is an inherited condition characterized by episodes of painful inflammation of the abdominal lining (peritonitis),  lining surrounding the lungs (pleurisy), and joints (arthralgia and occasionally arthritis). these episodes are often accompanied by fever and sometimes a characteristic ankle rash. the first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. between attacks, people often do not have any symptoms. without treatment, fmf can lead to kidney failure due to a buildup of certain protein deposits (amyloidosis). fmf is usually inherited in an autosomal recessive fashion and is caused by mutations in the mefv gene. last updated: 6/29/2012

Wikipedia:63 Familial Mediterranean fever (FMF), also known as Armenian disease, is a hereditary inflammatory... more...

Description from OMIM:46 249100

GeneReviews summary for fmf

Aliases & Classifications for Familial Mediterranean Fever

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Sources:
8Disease Ontology, 63Wikipedia, 19GeneReviews, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 46OMIM, 34MeSH, 27ICD9CM, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases


Aliases & Descriptions:

familial mediterranean fever 8 19 42 21 10 44 60
benign paroxysmal peritonitis 8 63 42 21
mediterranean fever, familial 63 20 22 21
familial paroxysmal polyserositis 63 42 21
recurrent polyserositis 63 19 21
periodic disease 63 42 21
fmf 63 42 21
hereditary periodic fever syndromes 21 44
wolff periodic disease 63 21
periodic peritonitis 63 21
periodic fever 42 60
fever 63 33
hereditary autoinflammatory diseases 60
hereditary periodic fever syndrome 63
siegal-cattan-mamou disease 21
reimann periodic disease 21
mef 21


External Ids:

Disease Ontology8 DOID:2987
OMIM46 249100
MeSH34 D010505
SNOMED-CT56 12579009
ICD9CM27 277.31
NCIt39 C84707
ICD1025 R50.8, R50.9

Related Diseases for Familial Mediterranean Fever

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17GeneCards, 18GeneDecks
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Diseases in the Familial Mediterranean Fever family:

Familial Mediterranean Fever Type 1 Familial Mediterranean Fever Type 2
Familial Mediterranean Fever, Ar Familial Mediterranean Fever, Ad

Diseases related to Familial Mediterranean Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1016)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis31.5SAA2, SAA4, SAA1, TNFRSF1A, CRP, MEFV
2arthritis31.1TNFRSF1A, TNF, IL1B
3multiple sclerosis30.8CASP1, TNFRSF1A, TNF, HLA-A, IL1B
4glomerulonephritis30.8IL1B
5encephalitis30.8IL1B
6rheumatoid arthritis30.7CASP1, SAA2, SAA4, SAA1, TNFRSF1A, TNF
7systemic lupus erythematosus30.7NOD2, CRP, HLA-A, TNF, TNFRSF1A
8malaria30.7HLA-A, TNF
9crohn's disease30.7NOD2, CRP, TNF
10vasculitis30.7MEFV, CRP, TNF
11erysipelas30.7MEFV
12spondylitis30.6NOD2
13ankylosing spondylitis30.6NOD2, CRP, TNF, TNFRSF1A
14celiac disease30.6HLA-A
15kawasaki disease30.6CRP
16measles30.6HLA-A
17brucellosis30.5SAA1, MEFV
18hepatitis30.5HLA-A, DBH
19atherosclerosis30.5SAA4, SAA1, TNF, CRP, IL1B, NOD2
20peritonitis30.5IL1B, MEFV, CRP, TNF
21tuberculosis30.5TNFRSF1A, TNF, HLA-A, CRP, IL1B, NOD2
22influenza30.4HLA-A, CASP1
23pericarditis30.4MEFV
24myositis30.4CASP1
25periodontitis30.4IL1B
26inflammatory bowel disease30.4TNFRSF1A, IL1B
27septic arthritis30.4CRP
28adult-onset still's disease30.4CRP
29sarcoidosis30.4NOD2, IL1B, HLA-A, TNF
30myopathy30.4MVK, CRP, GSN
31appendicitis30.4CRP
32relapsing fever30.4MVK, TNFRSF1A, MEFV
33ulcerative colitis30.4CASP1, TNF, CRP, IL1B, NOD2
34rheumatic fever30.4CRP
35acute leukemia30.3CASP1
36tumor necrosis factor receptor-associated periodic syndrome30.2MVK, TNFRSF1A, TNF, MEFV
37leishmaniasis30.2TNFRSF1A
38mevalonic aciduria30.2MVK
39myocardial infarction30.2CASP1, SAA4, SAA1, CRP
40palindromic rheumatism30.2MEFV
41alzheimer's disease30.2CASP1, SAA4, TNFRSF1A, DBH, IL1B, GSN
42osteomyelitis30.2CRP
43leukemia30.2CASP1, TNFRSF1A, TNF, HLA-A, DBH, IL1B
44psoriatic arthritis30.2CRP, TNF
45psoriasis30.2NOD2, IL1B, HLA-A, TNF, TNFRSF1A, CASP1
46asthma30.2TNF, IL1B, NOD2, GSN
47gingivitis30.2IL1B
48pancreatitis30.2IL1B, CRP, CASP1
49meningitis30.2SAA4, CRP, IL1B
50fabry disease30.2DBH

Graphical network of the top 20 diseases related to Familial Mediterranean Fever:



Diseases related to familial mediterranean fever

Clinical Features for Familial Mediterranean Fever

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46OMIM
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Clinical features from OMIM:

249100

Drugs & Therapeutics for Familial Mediterranean Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Familial Mediterranean Fever

Drug clinical trials:

Search ClinicalTrials for Familial Mediterranean Fever

Search NIH Clinical Center for Familial Mediterranean Fever

Search CenterWatch for Familial Mediterranean Fever

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Familial Mediterranean Fever

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20GeneTests, 22GTR
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Genetic tests related to Familial Mediterranean Fever:

id Genetic test Affiliating Genes
1 Familial Mediterranean Fever20 22 MEFV

Anatomical Context for Familial Mediterranean Fever

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32MalaCards
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MalaCards organs/tissues related to Familial Mediterranean Fever:

32
Kidney, Lung, Bone, Thyroid, Testes, Endothelial, Liver, Heart, Skin, Bone marrow, Colon, Breast, Brain, Monocytes, T cells

Animal Models for Familial Mediterranean Fever or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Familial Mediterranean Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.5GSN, DBH, MEFV, CASP1, NLRP3
2MP:000538710.4GSN, PYCARD, NLRP3, CASP1, TNFRSF1A, TNF
3MP:000537610.2TNFRSF1A, SAA1, CASP1, NLRP3, PYCARD, TNF

Publications for Familial Mediterranean Fever

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50PubMed
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Articles related to Familial Mediterranean Fever:

(show top 50)    (show all 724)
idTitleAuthorsYear
1
IL-1I^ biological treatment of familial Mediterranean fever. (23322405)
2013
2
Hashimoto's Thyroiditis in a Child with Familial Mediterranean Fever: a Case Report. (24427507)
2013
3
The prevalence of atopy in patients with familial Mediterranean fever and BehAset's disease. (24064018)
2013
4
Retrospective evaluation of pregnancy outcomes in women with familial Mediterranean fever. (23981183)
2013
5
Esophagitis and Widespread Aphthous Ulcerations in Gastric Mucosa in An Infant with Familial Mediterranean Fever. (23492736)
2013
6
Apoptosis-associated speck-like protein containing a CARD (ASC) expression profiles in familial Mediterranean fever (FMF) patients with different MEFV mutation patterns. (22934972)
2013
7
Two cases of familial Mediterranean fever associated with sarcoidosis (Lofgren's syndrome) and rheumatoid arthritis. (23981767)
2013
8
Ophthalmic manifestations in familial Mediterranean fever: a case series of 6 patients. (24338581)
2013
9
Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in BehAset disease. (23633568)
2013
10
Mortality risk factors associated with familial Mediterranean fever among a cohort of 1.25 million adolescents. (23505237)
2013
11
Neutrophil F-actin dynamics in Familial Mediterranean Fever: the unequal effect of colchicine on activated neutrophils. (23432575)
2013
12
Down-regulation of adiponectin in patients with familial Mediterranean fever during attack-free period. (21877244)
2012
13
Renal amyloidosis due to familial mediterranean fever misdiagnosed. (23716950)
2012
14
Enhanced exon 2 skipping caused by c.910G>A variant and alternative splicing of MEFV genes in two independent cases of familial Mediterranean fever. (21562927)
2012
15
Familial Mediterranean fever without cardinal symptoms and role of genetic screening. (22842301)
2012
16
Polyarteritis nodosa and Henoch-SchAPnlein purpura nephritis in a child with familial Mediterranean fever: a case report. (21259007)
2012
17
The impact of familial Mediterranean fever on women's health. (22713162)
2012
18
Atypical Henoch-Schonlein purpura: a forerunner of familial Mediterranean fever. (21598807)
2011
19
Evaluation of nailfold capillaries in familial Mediterranean fever patients. (21053037)
2011
20
Renal and suprarenal insufficiency secondary to familial Mediterranean fever associated with amyloidosis: a case report. (21851607)
2011
21
Familial Mediterranean fever presenting as anti-cyclic citrullinated peptide antibody negative palindromic rheumatism. (20808171)
2010
22
The role of inflammatory cytokines and NF-kappaB/MAPK signaling pathways in the evolution of familial Mediterranean fever: current clinical perspectives and potential therapeutic approaches. (19733345)
2009
23
Current perspectives on familial Mediterranean fever. (19339884)
2009
24
Evaluation of pathergy test positivity in familial Mediterranean fever patients and comparison of clinical manifestations of FMF with BehAset's disease. (19639361)
2009
25
Possible correlation between reversible and irreversible lesions in familial Mediterranean fever, soluble Fas, and C5a inhibitor activity: comment on the letter by Yasui and Yamazaki. (18512795)
2008
26
Familial Mediterranean fever in northwest of Iran (Ardabil): the first global report from Iran. (18365590)
2008
27
Effect of Helicobacter pylori infection and eradication therapy on interleukin-6 levels in patients with Familial Mediterranean Fever. (17343670)
2008
28
Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever. (18676303)
2008
29
Is the CD14 C159T polymorphism effective in the development of secondary amyloidosis in Familial Mediterranean fever? (17187267)
2007
30
Tumor necrosis factor-alpha gene promoter polymorphism in patients with familial Mediterranean fever. (17057944)
2007
31
Successful pregnancies in dialysis patients including those suffering from cystinosis and familial Mediterranean fever. (17136701)
2006
32
Familial Mediterranean fever in the Syrian population: gene mutation frequencies, carrier rates and phenotype-genotype correlation. (16627024)
2006
33
Circulating thrombomodulin levels in familial Mediterranean fever. (17067436)
2006
34
Mutational analysis of the PRYSPRY domain of pyrin and implications for familial mediterranean fever (FMF). (16730661)
2006
35
MEFV mutations in familial Mediterranean fever: association of M694V homozygosity with arthritis. (14727057)
2005
36
Relationship between HLA-DR, HLA-DQ alleles and MEFV gene mutations in familial Mediterranean fever (FMF) patients. (16245224)
2005
37
A case of familial Mediterranean fever and polyarteritis nodosa complicated by spontaneous perirenal and subcapsular hepatic hemorrhage requiring multiple arterial embolizations. (14712330)
2005
38
Amyloidosis in familial Mediterranean fever patients: correlation with MEFV genotype and SAA1 and MICA polymorphisms effects. (15018633)
2004
39
Application of refractory fragment amplification system for detection of Egyptian variant of Familial Mediterranean Fever. (15724392)
2004
40
Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population. (15170927)
2004
41
Familial Mediterranean fever associated pyrin mutations in Greece. (12695165)
2003
42
Mutations in the gene for familial Mediterranean fever: do they predispose to inflammation? (12966608)
2003
43
The significance of paired MEFV mutations in individuals without symptoms of familial Mediterranean fever. (12461684)
2002
44
MEFV gene mutations in familial Mediterranean fever phenotype II patients with renal amyloidosis in childhood: a retrospective clinicopathological and molecular study. (12401847)
2002
45
Prevalence and significance of the familial Mediterranean fever gene mutation encoding pyrin Q148. (11588211)
2001
46
Familial Mediterranean fever (FMF)-associated amyloidosis in childhood. Clinical features, course and outcome. (11760404)
2001
47
Identification of MEFV-independent modifying genetic factors for familial Mediterranean fever. (11017802)
2000
48
The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators. (10807793)
2000
49
Reflex sympathetic dystrophy arising in a patient with familial Mediterranean fever. (10651087)
1999
50
Autosomal dominant 'Mediterranean fever' in a Finnish family. (1402641)
1992

Genetic Variations for Familial Mediterranean Fever

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Expression for genes affiliated with Familial Mediterranean Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Mediterranean Fever

Search GEO for disease gene expression data for Familial Mediterranean Fever.

Pathways for genes affiliated with Familial Mediterranean Fever

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 12EMD Millipore, 51QIAGEN, 55SinoBiological, 4Cell Signaling Technology
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Pathways related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5PYCARD, NLRP3, CASP1, SAA1, PSTPIP1, HLA-A
2
Hide members
10.5NOD2, PYCARD, NLRP3, CASP1, TNF, PSTPIP1
3
Hide members
10.5PYCARD, NLRP3, CASP1, PSTPIP1, MEFV
410.5SAA2, SAA4, SAA1, TNF, CRP, IL1B
510.5SAA1, SAA4, SAA2
6
Hide members
10.5PYCARD, NLRP3, CASP1, TNF, IL1B, NOD2
7
Apoptosis and survival Caspase cascade
Hide members
10.5GSN, TNF, TNFRSF1A, CASP1
8
Hide members
10.5PYCARD, NLRP3, CASP1, TNFRSF1A, TNF, HLA-A
9
Hide members
10.5CASP1, TNFRSF1A, TNF
10
Hide members
10.5TNF, TNFRSF1A, CASP1
1110.5PYCARD, NLRP3, CASP1, TNF, IL1B
12
Hide members
10.5HLA-A, TNF, TNFRSF1A, CASP1
13
Hide members
10.5NOD2, IL1B, CASP1
14
Hide members
10.5IL1B, TNF, TNFRSF1A, CASP1
15
Hide members
10.5IL1B, TNF, TNFRSF1A, CASP1
16
Hide members
10.5CASP1, TNFRSF1A, TNF, IL1B
17
Hide members
10.5NOD2, IL1B, HLA-A, CASP1
1810.5CASP1, IL1B
1910.5CASP1, TNF, IL1B
2010.5TNFRSF1A, TNF, NOD2
2110.5DBH
2210.5PYCARD, CASP1
2310.5CASP1, PYCARD
24
Hide members
10.5NOD2
2510.5TNFRSF1A, TNF, IL1B, NOD2
2610.5TNFRSF1A, TNF, IL1B, NOD2
2710.5PYCARD, CASP1, TNF, IL1B
2810.5IL1B, CASP1, PYCARD
29
Hide members
10.5TNF, TNFRSF1A
3010.5TNFRSF1A, TNF, IL1B
31
Hide members
10.5IL1B, HLA-A, TNF, TNFRSF1A
3210.5IL1B, TNF, TNFRSF1A, PYCARD

Compounds for genes affiliated with Familial Mediterranean Fever

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44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1endotoxin4411.0GSN, MEFV, TNFRSF1A, SAA1, SAA4, CASP1
2mevalonate4411.0NLRP3, MEFV, TNFRSF1A, CASP1, MVK
3anakinra44 1112.0NLRP3, IL1B, CRP, TNF, MVK, CASP1
4dexamethasone44 49 28 1113.9DBH, CASP1, SAA2, SAA1
5lipid4410.9MVK, SAA1, CASP1, SAA4, TNFRSF1A, TNF
6tenidap44 2811.9SAA1
7infliximab44 49 1112.9NOD2, IL1B, CRP, TNF, TNFRSF1A
8simvastatin44 49 59 28 11 2415.9SAA1, CRP, TNF, TNFRSF1A, MVK
9neopterin4410.9SAA4, TNFRSF1A, IL1B, CRP, TNF
10etanercept44 49 1112.9TNF, IL1B, TNFRSF1A, CRP
11muramyl dipeptide44 2811.9CASP1, IL1B, NOD2
12leflunomide49 44 1112.9TNF, IL1B, TNFRSF1A, SAA4
13peptidoglycan44 2811.9CASP1, TNF, IL1B, NOD2
14alanine4410.9CRP, HLA-A, DBH, GSN, TNFRSF1A, MVK
15methotrexate44 49 1112.9TNFRSF1A, NLRP3, TNF, CRP, IL1B
16ivig4410.9TNF, TNFRSF1A, IL1B, CRP
17superoxide44 2411.9TNFRSF1A, TNF, DBH, IL1B, CASP1, GSN
18actinomycin4410.9IL1B, TNFRSF1A
19anisomycin44 1111.9TNF, TNFRSF1A, CASP1, IL1B
20n acetylcysteine4410.9IL1B, TNFRSF1A, CRP, TNF, CASP1
21sb 20358044 5911.9CRP, TNF, TNFRSF1A, IL1B, CASP1
22staurosporin4410.9IL1B, TNF, CASP1
23tpck4410.9IL1B, CASP1, TNF
24acetyl-tyr-val-ala-asp-cho4410.9CASP1, IL1B
25cuprophan4410.9IL1B, TNFRSF1A, CASP1
26fibrinogen4410.9SAA1, TNF, SAA4, CRP, GSN
27glucose4410.8SAA1, DBH, GSN, SAA4
28okt34410.8TNFRSF1A, CRP, TNF
29sulfasalazine44 28 49 1113.8TNF, CRP, IL1B
308-isoprostane4410.8CRP, SAA4, TNF
31hypericin4410.8CASP1, DBH
32ns 39844 5911.8TNFRSF1A, TNF, IL1B
33tocilizumab44 1111.8TNF, CRP
34serine4410.8DBH, PSTPIP1, TNF, CASP1, MVK, TNFRSF1A
35turpentine4410.8CRP, IL1B
36fmlp4410.8GSN
37prostacyclin4410.8TNF, CRP, TNFRSF1A, IL1B
38poly(i-c)4410.8IL1B, CASP1, TNF
39il 104410.7TNF, NOD2, IL1B
40pge24410.7DBH
41calcium44 49 11 2413.7CASP1, DBH, SAA4, NOD2, CRP, SAA1
42diphenyleneiodonium4410.7IL1B, TNF, CASP1
43cdp5714410.7TNF, CRP
44nitric oxide44 11 2412.6DBH, NOD2, CASP1, TNF, TNFRSF1A, IL1B
45pentoxifylline44 1111.6CASP1
46creatinine4410.6CASP1, TNFRSF1A, CRP, MVK, SAA4
47oxygen44 2411.5TNFRSF1A, CASP1, TNF, GSN, DBH
48c2ceramide4410.5TNFRSF1A, TNF, IL1B
49bucillamine4410.4CRP, IL1B
50tlck4410.2IL1B, CASP1

GO Terms for genes affiliated with Familial Mediterranean Fever

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16Gene Ontology
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Cellular components related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6GSN, PYCARD, CASP1, SAA4, SAA1, TNFRSF1A
2NLRP3 inflammasome complexGO:07255910.6CASP1, NLRP3, PYCARD
3cytosolGO:00582910.5NLRP3, CASP1, MVK, PSTPIP1, MEFV, IL1B
4high-density lipoprotein particleGO:03436410.5SAA2, SAA4, SAA1
5AIM2 inflammasome complexGO:09716910.4CASP1, PYCARD
6NLRP1 inflammasome complexGO:07255810.2CASP1, PYCARD

Biological processes related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:05072810.9NLRP3, MVK, SAA1, TNFRSF1A, MEFV
2nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:03587210.9NOD2, MEFV, PSTPIP1, CASP1, NLRP3, PYCARD
3positive regulation of interleukin-1 beta secretionGO:05071810.9NOD2, CASP1, NLRP3, PYCARD
4inflammatory responseGO:00695410.9PYCARD, NLRP3, TNFRSF1A, TNF, CRP, MEFV
5innate immune responseGO:04508710.9PYCARD, NLRP3, CASP1, SAA1, PSTPIP1, MEFV
6acute-phase responseGO:00695310.9SAA2, SAA4, SAA1, CRP
7interleukin-1 beta productionGO:03261110.9IL1B, CASP1, PYCARD
8positive regulation of NF-kappaB transcription factor activityGO:05109210.9PYCARD, NLRP3, TNF, IL1B, NOD2
9positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.9CASP1, TNFRSF1A, TNF, IL1B, NOD2
10positive regulation of interleukin-6 productionGO:03275510.9NOD2, IL1B, TNF, PYCARD
11apoptotic processGO:00691510.9PYCARD, NLRP3, CASP1, TNFRSF1A, TNF, IL1B
12positive regulation of JNK cascadeGO:04633010.9PYCARD, TNF, IL1B, NOD2
13activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.9PYCARD, NLRP3, CASP1, TNF
14positive regulation of tumor necrosis factor productionGO:03276010.8NOD2, TNFRSF1A, PYCARD
15positive regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328010.8PYCARD, NLRP3, TNF
16defense response to Gram-positive bacteriumGO:05083010.8TNF, CRP, NOD2
17positive regulation of interferon-gamma productionGO:03272910.8PYCARD, TNF, IL1B
18positive regulation of calcidiol 1-monooxygenase activityGO:06055910.8TNF, IL1B
19detection of biotic stimulusGO:00959510.8NLRP3, NOD2
20sequestering of triglycerideGO:03073010.8TNF, IL1B
21response to hypoxiaGO:00166610.8CASP1, TNFRSF1A, TNF, CRP
22positive regulation of heterotypic cell-cell adhesionGO:03411610.8IL1B, TNF
23positive regulation of cysteine-type endopeptidase activityGO:200105610.8MEFV, PYCARD
24positive regulation of fever generationGO:03162210.8IL1B, TNF
25cellular response to mechanical stimulusGO:07126010.8CASP1, TNFRSF1A, IL1B
26positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.7NOD2, TNF
27negative regulation of NF-kappaB transcription factor activityGO:03208810.7NOD2, NLRP3, PYCARD
28negative regulation of lipid storageGO:01088810.7TNF, CRP
29positive regulation of chemokine biosynthetic processGO:04508010.7IL1B, TNF
30positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.6IL1B, TNF, PYCARD
31response to ethanolGO:04547110.6TNFRSF1A, CRP, GSN
32regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.6IL1B, TNF
33negative regulation of interleukin-12 productionGO:03269510.6NOD2, MEFV
34activation of MAPK activityGO:00018710.5TNF, IL1B, NOD2
35negative regulation of lipid catabolic processGO:05099510.5IL1B, TNF
36positive regulation of ERK1 and ERK2 cascadeGO:07037410.4NOD2, TNF, PYCARD
37positive regulation of membrane protein ectodomain proteolysisGO:05104410.2IL1B, TNF

Molecular functions related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:04283410.5NOD2, NLRP3
2cysteine-type endopeptidase activityGO:00419710.2CASP1, CASP16, PYCARD

Products for genes affiliated with Familial Mediterranean Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Familial Mediterranean Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet