FMF
MCID: FML018
MIFTS: 76

Familial Mediterranean Fever (FMF) malady

Genetic diseases, Rare diseases, Immune diseases, Nephrological diseases, Bone diseases, Blood diseases categories
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Summaries for Familial Mediterranean Fever

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MedlinePlus:33 A fever is a body temperature that is higher than normal. it is not an illness. it is part of your body's defense against infection. most bacteria and viruses that cause infections do well at the body's normal temperature (98.6 f). a slight fever can make it harder for them to survive. fever also activates your body's immune system. infections cause most fevers. there can be many other causes, including medicines heat exhaustion cancers autoimmune diseases treatment depends on the cause of your fever. your health care provider may recommend using over-the-counter medicines such as acetaminophen or ibuprofen to lower a very high fever. adults can also take aspirin, but children with fevers should not take aspirin. it is also important to drink enough liquids to prevent dehydration.

MalaCards based summary: Familial Mediterranean Fever, also known as benign paroxysmal peritonitis, is related to polyarteritis nodosa and relapsing fever. An important gene associated with Familial Mediterranean Fever is MEFV (Mediterranean fever), and among its related pathways are Folate Metabolism and Amyotrophic lateral sclerosis (ALS). The drug colchicine and the compounds tenidap and geranylgeraniol have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and brain, and related mouse phenotypes are integument and hematopoietic system.

Genetics Home Reference:21 Familial Mediterranean fever is an inherited condition characterized by recurrent episodes of painful inflammation in the abdomen, chest, or joints. These episodes are often accompanied by fever and sometimes a rash or headache. Occasionally inflammation may occur in other parts of the body, such as the heart; the membrane surrounding the brain and spinal cord; and in males, the testicles. In about half of affected individuals, attacks are preceded by mild signs and symptoms known as a prodrome. Prodromal symptoms include mildly uncomfortable sensations in the area that will later become inflamed, or more general feelings of discomfort.

NIH Rare Diseases:42 Familial mediterranean fever (fmf) is an inherited condition characterized by episodes of painful inflammation of the abdominal lining (peritonitis),  lining surrounding the lungs (pleurisy), and joints (arthralgia and occasionally arthritis). these episodes are often accompanied by fever and sometimes a characteristic ankle rash. the first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. between attacks, people often do not have any symptoms. without treatment, fmf can lead to kidney failure due to a buildup of certain protein deposits (amyloidosis). fmf is usually inherited in an autosomal recessive fashion and is caused by mutations in the mefv gene. last updated: 6/29/2012

Wikipedia:65 Familial Mediterranean fever (FMF), is a hereditary inflammatory disorder. FMF is an autoinflammatory... more...

Description from OMIM:46 249100

GeneReviews summary for fmf

Aliases & Classifications for Familial Mediterranean Fever

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Familial Mediterranean Fever, Aliases & Descriptions:

Name: Familial Mediterranean Fever 8 19 42 21 10 44 62
Benign Paroxysmal Peritonitis 8 65 42 21 62
Recurrent Polyserositis 65 19 42 21
Familial Paroxysmal Polyserositis 65 42 21
Mediterranean Fever, Familial 65 20 22
Fmf 65 42 21
Wolff Periodic Disease 65 21
Periodic Peritonitis 65 42
Periodic Disease 65 42
 
Periodic Fever 42 62
Fever 65 33
Hereditary Autoinflammatory Diseases 62
Hereditary Periodic Fever Syndromes 44
Polyserositis, Familial Paroxysmal 62
Hereditary Periodic Fever Syndrome 65
Siegal-Cattan-Mamou Disease 21
Reimann Periodic Disease 21
Mef 21


Classifications:



External Ids:

Disease Ontology8 DOID:2987
ICD9CM27 277.31
NCIt39 C84707
SNOMED-CT57 12579009
MeSH34 D010505
OMIM46 249100
ICD1025 R50.8, R50.9

Related Diseases for Familial Mediterranean Fever

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Diseases in the Familial Mediterranean Fever family:

Familial Mediterranean Fever Type 1 Familial Mediterranean Fever Type 2
Familial Mediterranean Fever, Ar Familial Mediterranean Fever, Ad

Diseases related to Familial Mediterranean Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1075)
idRelated DiseaseScoreTop Affiliating Genes
1polyarteritis nodosa31.8MEFV
2relapsing fever31.7TNFRSF1A, MEFV, MVK
3pericarditis31.4MEFV
4brucellosis31.2SAA1, MEFV
5spondylitis31.1NOD2
6septic arthritis31.1CRP
7adult-onset still's disease31.1CRP
8palindromic rheumatism31.0MEFV
9amyloidosis30.9TNFRSF1A, DBH, SAA2, SAA1, MEFV, CRP
10hyper-igd syndrome30.9MVK
11peritonitis30.9CRP, MEFV
12inflammatory bowel disease30.8TNFRSF1A
13psoriatic arthritis30.8CRP
14periodic fever, familial, autosomal dominant30.8TNFRSF1A, MEFV, MVK
15crohn's disease30.8NOD2, CRP
16amyloidosis, renal30.6SAA2, SAA1, MEFV
17conjunctivitis30.5TNFRSF1A, NLRP3
18amyloidosis, secondary30.5SAA2, SAA1, MEFV, CRP
19systemic lupus erythematosus30.5TNFRSF1A, CRP, NOD2
20exanthem30.5NLRP3, CRP
21ankylosing spondylitis30.5TNFRSF1A, CRP, NOD2
22urticaria30.4NLRP3, CASP1
23ulcerative colitis30.4NOD2, CRP
24myocardial infarction30.4SAA1, CASP1, CRP
25synovitis30.3CRP, TNFRSF1A
26tuberculosis30.3NOD2, CRP, TNFRSF1A
27osteoarthritis30.3TNFRSF1A, SAA1, CRP
28septic shock30.2CRP, CASP1, TNFRSF1A
29acute pancreatitis30.2CRP, CASP1
30familial cold autoinflammatory syndrome30.2TNFRSF1A, MEFV, CASP1, NLRP3
31acute myocardial infarction30.1CRP, MEFV, SAA1
32behcet's disease30.1CRP, MEFV
33muckle-wells syndrome30.1NLRP3, CASP1, MEFV, TNFRSF1A
34uveitis30.0NOD2, TNFRSF1A
35psoriasis30.0TNFRSF1A, CASP1, NOD2
36sepsis29.9TNFRSF1A, CASP1, CRP, NOD2
37rheumatic disease29.8CRP, MEFV
38rheumatoid arthritis29.8TNFRSF1A, SAA2, SAA1, MEFV, CASP1, CRP
39arthropathy29.6CRP, NLRP3, NOD2
40chronic infantile neurological cutaneous articular syndrome29.6TNFRSF1A, MEFV, MVK, CASP1, NLRP3
41arthritis29.6NLRP3, CRP, CASP1, MVK, MEFV, PSTPIP1
42blau syndrome29.3MEFV, MVK, NLRP3, NOD2
43pyoderma gangrenosum29.0PSTPIP1, MEFV, MVK, NLRP3, NOD2
44hemorrhagic fever11.3
45spotted fever11.2
46q fever11.1
47typhoid fever11.1
48yellow fever11.1
49rift valley fever11.1
50rocky mountain spotted fever11.1

Graphical network of the top 20 diseases related to Familial Mediterranean Fever:



Diseases related to familial mediterranean fever

Symptoms for Familial Mediterranean Fever

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Clinical features from OMIM:

249100

Drugs & Therapeutics for Familial Mediterranean Fever

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Drug clinical trials:

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Search NIH Clinical Center for Familial Mediterranean Fever

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Familial Mediterranean Fever

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Genetic tests related to Familial Mediterranean Fever:

id Genetic test Affiliating Genes
1 Familial Mediterranean Fever20 22 MEFV

Anatomical Context for Familial Mediterranean Fever

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MalaCards organs/tissues related to Familial Mediterranean Fever:

32
Kidney, Heart, Brain, Spinal cord, Lung, Neutrophil, Bone, Thyroid, Testes, Liver, Endothelial, Bone marrow, Skin, Spleen, Colon, Monocytes, T cells

Animal Models for Familial Mediterranean Fever or affiliated genes

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MGI Mouse Phenotypes related to Familial Mediterranean Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.3NLRP3, CASP1, MEFV, DBH, TNFRSF1A
2MP:00053977.6TNFRSF1A, PSTPIP1, MEFV, CASP1, NLRP3, NOD2
3MP:00053907.6TNFRSF1A, DBH, MEFV, NLRP3, NOD2
4MP:00053877.2TNFRSF1A, PSTPIP1, MEFV, CASP1, CRP, NLRP3
5MP:00053766.8NOD2, TNFRSF1A, DBH, SAA1, MEFV, CASP1

Publications for Familial Mediterranean Fever

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Articles related to Familial Mediterranean Fever:

(show top 50)    (show all 741)
idTitleAuthorsYear
1
Erysipelas-like Erythema in a Patient with Familial Mediterranean Fever. (25362709)
2014
2
Quality of life in adult patients with Familial Mediterranean fever living in Germany or Turkey compared to healthy subjects: a study evaluating the effect of disease severity and country of residence. (23274441)
2013
3
Thyroid autoimmunity in patients with Familial Mediterranean Fever: preliminary results. (24302182)
2013
4
The kidney in familial Mediterranean fever. (24293619)
2013
5
The risk of familial Mediterranean fever in MEFV heterozygotes: a statistical approach. (23844200)
2013
6
Management of familial Mediterranean fever by colchicine does not normalize the altered profile of microbial long chain fatty acids in the human metabolome. (23373011)
2013
7
A very rare cause of pleuritic chest pain: bilateral pleuritis as a first sign of familial mediterranean Fever. (23401829)
2013
8
Misdiagnosis of familial Mediterranean fever in patients with Anderson-Fabry disease. (22905681)
2013
9
Infliximab therapy for familial Mediterranean fever-related amyloidosis: case series with long term follow-up. (22673790)
2012
10
Familial Mediterranean FeVer gene (MEFV) mutations as a modifier of systemic lupus erythematosus. (22532615)
2012
11
The expanded clinical profile and the efficacy of colchicine therapy in Egyptian children suffering from familial Mediterranean fever: a descriptive study. (23206577)
2012
12
The possible underlying pathophysiological mechanisms for development of multiple sclerosis in familial Mediterranean fever. (22406096)
2012
13
Myalgia as a symptom of familial Mediterranean fever in children. (22020390)
2012
14
Down-regulation of adiponectin in patients with familial Mediterranean fever during attack-free period. (21877244)
2012
15
QT variability in amyloidosis of familial Mediterranean fever. (22675838)
2012
16
Familial Mediterranean fever with a single MEFV mutation: can a deletion resulting in I+-thalassemia be the cause? (21179105)
2011
17
Colchicine and ocular surface changes in familial Mediterranean fever. (19681787)
2010
18
Familial Mediterranean fever in Iranian children. First report from Iran. (20483055)
2010
19
Protracted febrile myalgia in two children with familial Mediterranean fever. (20723111)
2010
20
Protracted synovitis without systemic manifestations in familial Mediterranean fever (FMF). (20868584)
2010
21
A rare presentation of familial mediterranean Fever; acute scrotum and hydrocele amyloidosis. (23056732)
2010
22
Neuroendocrine immune system in familial Mediterranean fever. (21428190)
2010
23
Skin and muscle involvement as presenting symptoms in four children with familial Mediterranean fever. (19240979)
2009
24
The role of inflammatory cytokines and NF-kappaB/MAPK signaling pathways in the evolution of familial Mediterranean fever: current clinical perspectives and potential therapeutic approaches. (19733345)
2009
25
Plasma ghrelin levels in patients with Familial Mediterranean Fever. (19601914)
2009
26
Familial Mediterranean fever and IgA nephropathy: case report and review of the literature. (18793551)
2008
27
Assessment of aortic wall stiffness in patients with Familial Mediterranean Fever. (18375166)
2008
28
MEFV gene 3'-UTR Alu repeat polymorphisms in patients with familial Mediterranean fever. (19026119)
2008
29
Familial Mediterranean fever. Rare manifestation without fever and with inconspicuous family case history]. (18651363)
2008
30
Heightened endotoxin susceptibility of monocytes and neutrophils during familial Mediterranean fever. (18294193)
2008
31
Familial Mediterranean fever in three Japanese patients, and a comparison of the frequency of MEFV gene mutations in Japanese and Mediterranean populations. (18097735)
2008
32
The familial Mediterranean fever (MEFV) gene may be a modifier factor of inflammatory bowel disease in infancy. (17520284)
2008
33
Analysis of familial Mediterranean fever gene mutations in 202 patients with familial Mediterranean fever. (18662100)
2008
34
Anakinra: new therapeutic approach in children with Familial Mediterranean Fever resistant to colchicine. (18541452)
2008
35
Possible correlation between reversible and irreversible lesions in familial Mediterranean fever, soluble Fas, and C5a inhibitor activity: comment on the letter by Yasui and Yamazaki. (18512795)
2008
36
Country as the primary risk factor for renal amyloidosis in familial Mediterranean fever. (17469185)
2007
37
MEFV mutations in Tunisian patients suffering from familial Mediterranean fever. (17276496)
2007
38
ABCC6 is unlikely to be a modifier gene for familial Mediterranean fever severity. (18305351)
2007
39
Arg753Gln TLR-2 polymorphism in familial mediterranean fever: linking the environment to the phenotype in a monogenic inflammatory disease. (17013994)
2006
40
Successful pregnancies in dialysis patients including those suffering from cystinosis and familial Mediterranean fever. (17136701)
2006
41
Familial Mediterranean fever in the Syrian population: gene mutation frequencies, carrier rates and phenotype-genotype correlation. (16627024)
2006
42
Increased frequency of mutations in the gene responsible for familial Mediterranean fever (MEFV) in a cohort of patients with ulcerative colitis: evidence for a potential disease-modifying effect? (16614989)
2006
43
MEFV mutations in familial Mediterranean fever: association of M694V homozygosity with arthritis. (14727057)
2005
44
Sacroiliitis in familial Mediterranean fever and seronegative spondyloarthropathy: importance of differential diagnosis. (15711787)
2005
45
Genetic risk factors of amyloidogenesis in familial Mediterranean fever. (16118480)
2005
46
Role of A-SAA in monitoring subclinical inflammation and in colchicine dosage in familial Mediterranean fever. (12942707)
2003
47
A case of osteopoikilosis coexisting with amyloidosis of familial Mediterranean fever. (14586673)
2003
48
Familial Mediterranean fever (FMF) and renal AA amyloidosis--phenotype-genotype correlation, treatment and prognosis. (12832747)
2003
49
Familial Mediterranean fever: report of a case]. (11211479)
2000
50
Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)
1995

Variations for Familial Mediterranean Fever

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Clinvar genetic disease variations for Familial Mediterranean Fever:

6 (show all 17)
id Gene Name Type Significance SNP ID Assembly Location
1MEFVNM_000243.2(MEFV): c.2080A> G (p.Met694Val)single nucleotide variantPathogenicrs61752717GRCh37Chr 16, 3293407: 3293407
2MEFVNM_000243.2(MEFV): c.2082G> A (p.Met694Ile)single nucleotide variantPathogenicrs28940578GRCh37Chr 16, 3293405: 3293405
3MEFVNM_000243.2(MEFV): c.2177T> C (p.Val726Ala)single nucleotide variantPathogenicrs28940579GRCh37Chr 16, 3293310: 3293310
4MEFVNM_000243.2(MEFV): c.442G> C (p.Glu148Gln)single nucleotide variantPathogenicrs3743930GRCh37Chr 16, 3304626: 3304626
5MEFVNM_000243.2(MEFV): c.501G> C (p.Glu167Asp)single nucleotide variantPathogenicrs104895079GRCh37Chr 16, 3304567: 3304567
6MEFVNM_000243.2(MEFV): c.800C> T (p.Thr267Ile)single nucleotide variantPathogenicrs104895081GRCh37Chr 16, 3304268: 3304268
7MEFVNM_000243.2(MEFV): c.1437C> G (p.Phe479Leu)single nucleotide variantPathogenicrs104895083GRCh37Chr 16, 3297166: 3297166
8MEFVNM_000243.2(MEFV): c.2074_2076delATA (p.Ile692del)deletionPathogenicrs121907890GRCh37Chr 16, 3293411: 3293413
9MEFVNM_000243.2(MEFV): c.2084A> G (p.Lys695Arg)single nucleotide variantPathogenicrs104895094GRCh37Chr 16, 3293403: 3293403
10MEFVNM_000243.2(MEFV): c.2230G> T (p.Ala744Ser)single nucleotide variantPathogenicrs61732874GRCh37Chr 16, 3293257: 3293257
11MEFVNM_000243.2(MEFV): c.2282G> A (p.Arg761His)single nucleotide variantPathogenicrs104895097GRCh37Chr 16, 3293205: 3293205
12MEFVNM_000243.2(MEFV): c.2040G> A (p.Met680Ile)single nucleotide variantPathogenicrs28940580GRCh37Chr 16, 3293447: 3293447
13MEFVNM_000243.2(MEFV): c.1958G> A (p.Arg653His)single nucleotide variantPathogenicrs104895085GRCh37Chr 16, 3293529: 3293529
14MEFVNM_000243.2(MEFV): c.443A> T (p.Glu148Val)single nucleotide variantLikely pathogenicrs104895076GRCh37Chr 16, 3304625: 3304625
15MEFVNM_000243.2(MEFV): c.2082G> A (p.Met694Ile)single nucleotide variantPathogenicrs28940578GRCh37Chr 16, 3293405: 3293405
16MEFVNM_000243.2(MEFV): c.1432C> T (p.His478Tyr)single nucleotide variantPathogenicrs104895105GRCh37Chr 16, 3297171: 3297171
17MEFVNM_000243.2(MEFV): c.2040G> C (p.Met680Ile)single nucleotide variantPathogenicrs28940580GRCh37Chr 16, 3293447: 3293447

Expression for genes affiliated with Familial Mediterranean Fever

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Expression patterns in normal tissues for genes affiliated with Familial Mediterranean Fever

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Pathways for genes affiliated with Familial Mediterranean Fever

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Pathways related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Vitamin B12 Metabolism37
9.9SAA1, SAA2
2
Show member pathways
Amyotrophic lateral sclerosis (ALS)37
9.6CASP1, TNFRSF1A
3
Show member pathways
thioredoxin pathway37
9.3SAA2, SAA1, CRP
4
Show member pathways
IL-1 Signaling Pathway37
IL1-mediated signaling events37
9.3NOD2, CASP1
5
Show member pathways
9.2TNFRSF1A, CASP1, NLRP3
69.1NOD2, TNFRSF1A
7
Show member pathways
9.0NOD2, CASP1, SAA1
8
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.9CASP1, NLRP3, NOD2
9
Show member pathways
8.2NOD2, NLRP3, CASP1, MEFV, PSTPIP1

Compounds for genes affiliated with Familial Mediterranean Fever

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Compounds related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1tenidap44 2811.0CRP, SAA1
2geranylgeraniol4410.0MVK, CASP1
3cuprophan449.9CASP1, TNFRSF1A
4hypericin449.9CASP1, DBH
5dutp449.8TNFRSF1A, CASP1
6adalimumab44 50 1111.8CRP, TNFRSF1A
7colchicine44 61 2 28 1113.8MEFV, SAA1, TNFRSF1A
8nh4cl449.8TNFRSF1A, CRP
9okt3449.7TNFRSF1A, CRP
10muramyl dipeptide44 2810.7NOD2, CASP1
11p005449.6CRP, TNFRSF1A
12etanercept44 50 1111.6TNFRSF1A, CRP
13lactulose449.5NOD2, CRP
14fluvastatin44 50 28 1112.5CRP, CASP1
15methotrexate50 44 1111.4TNFRSF1A, CRP, NLRP3
16ivig449.4TNFRSF1A, CRP
17n acetylcysteine449.4CRP, CASP1, TNFRSF1A
18peptidoglycan44 2810.3NOD2, CASP1
19sb 20358044 6110.3CRP, CASP1, TNFRSF1A
20ganciclovir44 1110.3DBH, TNFRSF1A
21histidine449.3CASP1, MVK, DBH
22phenylalanine449.2MVK, DBH, TNFRSF1A
23ethanol44 50 24 1112.2CASP1, DBH, TNFRSF1A
24anakinra44 1110.2MVK, CASP1, CRP, NLRP3
25simvastatin44 50 61 28 24 1114.1TNFRSF1A, SAA1, MVK, CRP
26norepinephrine44 24 1111.0CRP, DBH, TNFRSF1A
27cholesterol44 28 24 1112.0TNFRSF1A, SAA1, MVK, CRP
28infliximab44 50 1111.0TNFRSF1A, CRP, NOD2
29creatinine449.0CRP, CASP1, MVK, TNFRSF1A
30mevalonate448.9NLRP3, CASP1, MVK, MEFV, TNFRSF1A
31atp44 289.9NLRP3, CASP1, MVK, TNFRSF1A
32dexamethasone44 50 28 1111.8TNFRSF1A, DBH, SAA2, SAA1, CASP1
33pge2448.7CASP1, DBH, TNFRSF1A
34tyrosine448.5TNFRSF1A, DBH, PSTPIP1, MEFV, CASP1
35glucose448.5TNFRSF1A, DBH, SAA1, CASP1, CRP
36alanine448.5TNFRSF1A, DBH, SAA1, MVK, CRP
37nitric oxide44 24 1110.5NOD2, CASP1, DBH, TNFRSF1A
38threonine448.4TNFRSF1A, MVK, CASP1, NLRP3, NOD2
39oxygen44 249.3NOD2, CASP1, DBH, TNFRSF1A
40lipid448.1CRP, CASP1, MVK, SAA1, DBH, TNFRSF1A
41endotoxin448.1NOD2, CRP, CASP1, MEFV, SAA1, TNFRSF1A
42calcium44 50 24 1110.7TNFRSF1A, DBH, SAA1, CASP1, CRP, NOD2
43serine447.7TNFRSF1A, DBH, PSTPIP1, MVK, CASP1, NOD2

GO Terms for genes affiliated with Familial Mediterranean Fever

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Cellular components related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NLRP3 inflammasome complexGO:0725599.8NLRP3, CASP1
2high-density lipoprotein particleGO:0343649.8SAA1, SAA2
3extracellular regionGO:0055768.1CRP, CASP1, SAA1, DBH, TNFRSF1A
4cytosolGO:0058297.5PSTPIP1, MEFV, MVK, CASP1, NLRP3, NOD2

Biological processes related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1interleukin-1 beta productionGO:03261110.0NLRP3, CASP1
2acute-phase responseGO:0069539.6CRP, SAA1, SAA2
3negative regulation of interleukin-12 productionGO:0326959.6MEFV, NOD2
4cellular response to mechanical stimulusGO:0712609.6CASP1, TNFRSF1A
5detection of biotic stimulusGO:0095959.6NLRP3, NOD2
6protein oligomerizationGO:0512599.4NOD2, NLRP3
7defense response to Gram-positive bacteriumGO:0508309.3CRP, NOD2
8regulation of inflammatory responseGO:0507279.3CASP1, NOD2
9positive regulation of tumor necrosis factor productionGO:0327609.2NOD2, TNFRSF1A
10response to hypoxiaGO:0016669.2CRP, CASP1, TNFRSF1A
11positive regulation of interleukin-1 beta secretionGO:0507189.2NOD2, NLRP3, CASP1
12defense responseGO:0069529.2NOD2, NLRP3
13negative regulation of NF-kappaB transcription factor activityGO:0320889.0NOD2, NLRP3
14response to lipopolysaccharideGO:0324969.0NOD2, CASP1, TNFRSF1A
15positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.0NOD2, CASP1, TNFRSF1A
16negative regulation of inflammatory responseGO:0507288.9TNFRSF1A, SAA1, MEFV, MVK, NLRP3
17inflammatory responseGO:0069548.7TNFRSF1A, PSTPIP1, MEFV, CRP, NLRP3
18nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:0358728.6NOD2, NLRP3, CASP1, MEFV, PSTPIP1
19innate immune responseGO:0450878.3SAA1, PSTPIP1, MEFV, CASP1, NLRP3, NOD2

Molecular functions related to Familial Mediterranean Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:0428349.3NOD2, NLRP3

Products for genes affiliated with Familial Mediterranean Fever

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Sources for Familial Mediterranean Fever

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3CDC
13ExPASy
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