Familial Mediterranean Fever, Ar malady
Genetic diseases, Rare diseases, Nephrological diseases, Bone diseases, Blood diseases categories
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Aliases & Descriptions for Familial Mediterranean Fever, Ar:
MalaCards categories: See all MalaCards categories (disease lists)
Global: Genetic diseases, Rare diseases
Anatomical: Nephrological diseases, Bone diseases, Blood diseases
Rare renal diseases
Rare systemic and rhumatological diseases
Rare immunological diseases
Characteristics (Orphanet epidemiological data):48
familial mediterranean fever:
Inheritance: Autosomal recessive; Age of onset: Adolescent,Adult,Childhood,Infancy; Age of death: normal life expectancy
MedlinePlus:32 A fever is a body temperature that is higher than normal. it is not an illness. it is part of your body's defense against infection. most bacteria and viruses that cause infections do well at the body's normal temperature (98.6 f). a slight fever can make it harder for them to survive. fever also activates your body's immune system. infections cause most fevers. there can be many other causes, including medicines heat exhaustion cancers autoimmune diseases treatment depends on the cause of your fever. your health care provider may recommend using over-the-counter medicines such as acetaminophen or ibuprofen to lower a very high fever. adults can also take aspirin, but children with fevers should not take aspirin. it is also important to drink enough liquids to prevent dehydration.
MalaCards based summary: Familial Mediterranean Fever, Ar, also known as familial mediterranean fever, is related to hemorrhagic fever and spotted fever, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Familial Mediterranean Fever, Ar is MEFV (Mediterranean fever). The drug colchicine has been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and brain.
Disease Ontology:8 A hypersensitivity reaction type ii disease characterized by recurrent episodes of fever and acute inflammation of the membranes lining the abdomen, joints and lungs; caused by mutations in the mefv gene, which encodes the protein pyrin.
NIH Rare Diseases:42 Familial mediterranean fever (fmf) is an inherited condition characterized by episodes of painful inflammation of the abdominal lining (peritonitis), lining surrounding the lungs (pleurisy), and joints (arthralgia and occasionally arthritis). these episodes are often accompanied by fever and sometimes a characteristic ankle rash. the first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. between attacks, people often do not have any symptoms. without treatment, fmf can lead to kidney failure due to a buildup of certain protein deposits (amyloidosis). fmf is usually inherited in an autosomal recessive fashion and is caused by mutations in the mefv gene. last updated: 6/29/2012
Genetics Home Reference:21 Familial Mediterranean fever is an inherited condition characterized by recurrent episodes of painful inflammation in the abdomen, chest, or joints. These episodes are often accompanied by fever and sometimes a rash or headache. Occasionally inflammation may occur in other parts of the body, such as the heart; the membrane surrounding the brain and spinal cord; and in males, the testicles. In about half of affected individuals, attacks are preceded by mild signs and symptoms known as a prodrome. Prodromal symptoms include mildly uncomfortable sensations in the area that will later become inflamed, or more general feelings of discomfort.
OMIM:46 Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by recurrent attacks of fever and... (249100) more...
GeneReviews summary for fmf
Symptoms by clinical synopsis from OMIM:249100
Clinical features from OMIM:249100
Symptoms:48 (show all 39)
HPO human phenotypes related to Familial Mediterranean Fever, Ar:(show all 49)
MalaCards organs/tissues related to Familial Mediterranean Fever, Ar:31
Lung, Kidney, Brain, Spinal cord, Heart, Bone, Skin, Testes, Liver
Articles related to Familial Mediterranean Fever, Ar:
UniProtKB/Swiss-Prot genetic disease variations for Familial Mediterranean Fever, Ar:63 (show all 43)
Clinvar genetic disease variations for Familial Mediterranean Fever, Ar:5 (show all 21)
Search GEO for disease gene expression data for Familial Mediterranean Fever, Ar.
26ICD10 via Orphanet
34MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
62UMLS via Orphanet