MCID: FML010
MIFTS: 62

Familial Medullary Thyroid Carcinoma malady

Cancer diseases, Genetic diseases categories

Summaries for Familial Medullary Thyroid Carcinoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 The term multiple endocrine neoplasia (MEN) encompasses several distinct syndromes featuring tumors of... more...

MalaCards: Familial Medullary Thyroid Carcinoma, also known as thyroid carcinoma, familial medullary, is related to thyroiditis and thyroid medullary carcinoma. An important gene associated with Familial Medullary Thyroid Carcinoma is NTRK1 (neurotrophic tyrosine kinase, receptor, type 1), and among its related pathways are ARMS-mediated activation and TRKA activation by NGF. The compounds cipa and glutamate have been mentioned in the context of this disorder. Affiliated tissues include thyroid and testes, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Description from OMIM:46 155240

Aliases & Classifications for Familial Medullary Thyroid Carcinoma

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8Disease Ontology, 10DISEASES, 20GeneTests, 22GTR, 44Novoseek, 60UMLS, 46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases


Aliases & Descriptions:

familial medullary thyroid carcinoma 8 10
thyroid carcinoma, familial medullary 8 20 22 44 60
medullary thyroid carcinoma, familial 46


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Disease Ontology8 DOID:0050547
OMIM46 155240

Related Diseases for Familial Medullary Thyroid Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Thyroid Medullary Carcinoma family:

familial medullary thyroid carcinoma Ntrk1-Related Familial Medullary Thyroid Carcinoma

Diseases related to Familial Medullary Thyroid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.8CALCA
2thyroid medullary carcinoma31.8CALCA, NTRK1, GDNF, RET
3pheochromocytoma30.7RET, SDHD, SDHB
4hirschsprung's disease30.7NTRK1, GDNF, RET
5papillary carcinoma30.5RET, NTRK1, CALCA
6papillary thyroid carcinoma30.5STAT3, NTRK1, RET
7phaeochromocytoma30.5SDHB, SDHD, RET, CALCA, SDHC
8parathyroid carcinoma30.3RET
9follicular thyroid carcinoma30.3CALCA, RET
10adenoma30.3CALCA, NTRK1, MAPK3, GDNF, RET
11amyloidosis10.5
12ntrk1-related familial medullary thyroid carcinoma10.4
13sipple syndrome10.2
14primary cutaneous amyloidosis10.2
15adrenal carcinoma10.2
16parathyroid adenoma10.2
17transitional cell carcinoma10.2
18neuroendocrine tumor10.0CALCA
19insulinoma10.0CALCA
20leprosy10.0SDHD
21hypertension10.0CALCA
22sarcoma10.0NTRK1
23neuroblastoma10.0NTRK1
24primary hyperoxaluria10.0FOS
25rhabdomyosarcoma10.0NTRK1
26central hypoventilation syndrome10.0GDNF
27asthma10.0FOS
28thymoma10.0NTRK1
29paragangliomas 110.0RET, SDHB
30nodular goiter10.0RET, CALCA
31chagas disease10.0NTRK1
32pituitary adenoma10.0GDNF, RET
33obesity10.0STAT3
34neurofibromatosis10.0SDHB, SDHD
35parkinson's disease10.0GDNF, FOS
36primary hyperparathyroidism10.0RET, CALCA
37amyotrophic lateral sclerosis10.0GDNF, NTRK1
38insulin resistance10.0FOS
39glomus tumor10.0SDHD, SDHB
40carcinoid syndrome10.0SDHD, RET, CALCA
41familial colorectal cancer10.0RET, SDHD, SDHB
42toxic encephalopathy10.0GDNF, FOS
43osteoarthritis10.0NTRK1, CALCA
44hereditary paraganglioma-pheochromocytoma syndromes10.0SDHC, SDHB, SDHD
45paraganglioma and gastric stromal sarcoma10.0SDHD, SDHB, SDHC
46carotid body tumor10.0SDHD, SDHB, SDHC
47diabetic neuropathy10.0NTRK1, GDNF
48carney triad10.0SDHD, SDHB, SDHC
49intestinal obstruction10.0RET, GDNF
50chondroma10.0SDHD, SDHB, SDHC

Graphical network of the top 20 diseases related to Familial Medullary Thyroid Carcinoma:



Diseases related to familial medullary thyroid carcinoma

Clinical Features for Familial Medullary Thyroid Carcinoma

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46OMIM
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Clinical features from OMIM:

155240

Clinical synopsis from OMIM:

155240

Drugs & Therapeutics for Familial Medullary Thyroid Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Familial Medullary Thyroid Carcinoma

Drug clinical trials:

Search ClinicalTrials for Familial Medullary Thyroid Carcinoma

Search NIH Clinical Center for Familial Medullary Thyroid Carcinoma

Search CenterWatch for Familial Medullary Thyroid Carcinoma

Genetic Tests for Familial Medullary Thyroid Carcinoma

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20GeneTests, 22GTR
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Genetic tests related to Familial Medullary Thyroid Carcinoma:

id Genetic test Affiliating Genes
1 Familial Medullary Thyroid Carcinoma20 22

Anatomical Context for Familial Medullary Thyroid Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Familial Medullary Thyroid Carcinoma:

32
Thyroid, Testes

Animal Models for Familial Medullary Thyroid Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Familial Medullary Thyroid Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6NTRK1, MAPK3, GDNF, RET
2MP:00053798.3RET, GDNF, STAT3, FOS
3MP:00028737.9CALCA, FOS, STAT3, NTRK1, RET, SDHD
4MP:00036317.8FOS, STAT3, NTRK1, GDNF, RET, SDHD
5MP:00020067.7SDHD, CALCA, FOS, STAT3, MAPK3, RET
6MP:00053857.5CALCA, STAT3, MAPK3, GDNF, RET, SDHD
7MP:00053977.1FOS, STAT3, NTRK1, MAPK3, GDNF, RET
8MP:00053787.1FOS, STAT3, NTRK1, MAPK3, GDNF, RET
9MP:00053866.8CALCA, FOS, STAT3, NTRK1, MAPK3, GDNF
10MP:00107686.4CALCA, FOS, STAT3, NTRK1, MAPK3, GDNF

Publications for Familial Medullary Thyroid Carcinoma

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50PubMed
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Articles related to Familial Medullary Thyroid Carcinoma:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
Familial history of non-medullary thyroid cancer is an independent prognostic factor for tumor recurrence in younger patients with conventional papillary thyroid carcinoma. (24132694)
2014
2
Role of prophylactic thyroidectomy in RET 790 familial medullary thyroid carcinoma. (21688339)
2012
3
Mutation screening of RET proto-oncogene in a family with medullary thyroid carcinoma, marfanoid habitus and pheochromocytoma; from clinically MEN2B to genetically MEN2A syndrome. (22290487)
2012
4
Case report: a p.C618S RET proto-oncogene germline mutation in a large Chinese pedigree with familial medullary thyroid carcinoma. (22068382)
2012
5
Coexistent familial nonmultiple endocrine neoplasia medullary thyroid carcinoma and papillary thyroid carcinoma associated with RET polymorphism. (20463576)
2010
6
Familial medullary thyroid carcinoma associated with cutaneous lichen amyloidosis. (19445625)
2009
7
Familial non-medullary thyroid carcinoma (FNMTC): analysis of fPTC/PRN, NMTC1, MNG1 and TCO susceptibility loci and identification of somatic BRAF and RAS mutations. (18310288)
2008
8
The RET mutation E768D confers a late-onset familial medullary thyroid carcinoma -- only phenotype with incomplete penetrance: implications for screening and management of carrier status. (16736292)
2006
9
A novel Czech kindred with familial medullary thyroid carcinoma and Hirschsprung's disease. (15991157)
2005
10
No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinoma. (16322339)
2005
11
Penetrance and clinical manifestations of non-hotspot germline RET mutation, C630R, in a family with medullary thyroid carcinoma. (16053382)
2005
12
The familial medullary thyroid carcinoma-associated RET E768D mutation in a multiple endocrine neoplasia type 2A case. (15855933)
2005
13
A novel point mutation of the RET protooncogene involving the second intracellular tyrosine kinase domain in a family with medullary thyroid carcinoma. (15240641)
2004
14
Timing and extent of surgery in patients with familial medullary thyroid carcinoma/multiple endocrine neoplasia 2A-related RET mutations not affecting codon 634. (15517481)
2004
15
Emergence of medullary thyroid carcinoma in a family with the Cys630Arg RET germline mutation. (15523405)
2004
16
Study of RET protooncogene in multiple endocrine neoplasm 2A and in familial medullary thyroid carcinoma. Clinical pathological findings in asymptomatic carriers]. (12673960)
2003
17
Treatment of familial medullary thyroid carcinoma]. (14663408)
2003
18
RET oncogene mutations in medullary thyroid carcinoma in Mexican families. (12604374)
2003
19
Various penetrance of familial medullary thyroid carcinoma in patients with RET protooncogene codon 790/791 germline mutations. (12409662)
2002
20
Molecular genetic diagnostic program of multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma syndromes in Hungary. (11524247)
2001
21
Familial medullary thyroid carcinoma and prominent corneal nerves associated with the germline V804M and V778I mutations on the same allele of RET. (11732489)
2001
22
Familial medullary thyroid carcinoma with noncysteine ret mutations: phenotype-genotype relationship in a large series of patients. (11502806)
2001
23
Incidental detection of familial medullary thyroid carcinoma by calcitonin screening for nodular thyroid disease. (10474127)
1999
24
Prognosis of a family with familial medullary thyroid carcinoma. (10464711)
1999
25
Psychosocial impact of genetic testing in familial medullary-thyroid carcinoma: a multicentric pilot-evaluation. (10076727)
1999
26
Familial medullary thyroid carcinoma: presymptomatic diagnosis and management in children. (10484798)
1999
27
Novel point mutation in exon 10 of the RET proto-oncogene in a family with medullary thyroid carcinoma. (9677065)
1998
28
A GTG to ATG novel point mutation at codon 804 in exon 14 of the RET proto-oncogene in two families affected by familial medullary thyroid carcinoma. (9452077)
1998
29
Results of the calcitonin stimulation test in normal volunteers compared with genetically unaffected members of MEN 2A and familial medullary thyroid carcinoma families. (9436479)
1997
30
Omeprazole: calcitonin stimulation test for the diagnosis follow-up and family screening in medullary thyroid carcinoma. (9062503)
1997
31
Prevalence and parental origin of de novo RET mutations in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma. Le Groupe d'Etude des Tumeurs a Calcitonine. (8981969)
1997
32
Cys 618 Arg mutation in the RET proto-oncogene associated with familial medullary thyroid carcinoma and maternally transmitted Hirschsprung's disease suggesting a role for imprinting. (9259198)
1997
33
A novel point mutation in the intracellular domain of the ret protooncogene in a family with medullary thyroid carcinoma. (9398735)
1997
34
Familial medullary thyroid carcinoma: not a distinct entity? Genotype-phenotype correlation in a large family. (9003111)
1996
35
Immune response against medullary thyroid carcinoma (MTC) induced by parental and/or interleukin-2-secreting MTC cells in a rat model of human familial medullary thyroid carcinoma. (8954146)
1996
36
Rudolf-Virchow-Preis 1995. The role of RET proto-oncogene mutation analysis in the diagnosis of multiple endocrine neoplasia type 2 (MEN 2) gene carriers and in the discrimination of sporadic and familial medullary thyroid carcinomas and pheochromocytomas. (8600671)
1995
37
Multiple endocrine neoplasia type 2A, type 2B and familial medullary thyroid carcinoma syndrome]. (8538031)
1995
38
Mapping the inherited defects associated with multiple endocrine neoplasia type 2A, multiple endocrine neoplasia type 2B, and familial medullary thyroid carcinoma to chromosome 10 by linkage analysis. (7913024)
1994
39
The prognostic importance of calcitonin screening in familial medullary thyroid carcinoma]. (8425457)
1993
40
Familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2B map to the same region of chromosome 10 as multiple endocrine neoplasia type 2A. (1672289)
1991
41
Primary localized cutaneous amyloidosis and familial medullary thyroid carcinoma. (1889128)
1991
42
Cutaneous lichen amyloidosis and familial medullary thyroid carcinoma. (1969255)
1990
43
Calcitonin, calcitonin gene-related peptide, and gastrin-releasing peptide in familial thyroid medullary carcinoma. (2300897)
1990
44
Monoclonal immunoradiometric assay of calcitonin improves investigation of familial medullary thyroid carcinoma. (2302785)
1990
45
Clinical characteristics in sporadic and familial medullary thyroid carcinoma. A nationwide study of 249 patients in Sweden from 1959 through 1981. (2563669)
1989
46
Familial medullary thyroid carcinoma in multiple endocrine neoplasia (MEN) IIa: diagnosis and problems in treatment. (6127216)
1982
47
Light-electron microscopic and cytochemical studies on the morphogenesis of familial medullary thyroid carcinoma. (145082)
1977
48
Familial medullary thyroid carcinoma and pheochromocytoma: epidemiologic investigations. (4359415)
1974
49
Familial medullary thyroid carcinoma, pheochromocytoma, and parathyroid adenoma (Sipple's syndrome). Study of a kindred. (5125671)
1971
50
Two cell types in familial medullary thyroid carcinoma. A histochemical study. (5310020)
1970

Genetic Variations for Familial Medullary Thyroid Carcinoma

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Familial Medullary Thyroid Carcinoma:

62 (show all 30)
id Symbol AA change Variation ID SNP ID
1RETp.Cys609TyrVAR_006306rs77939446
2RETp.Cys611TrpVAR_006308rs80069458
3RETp.Cys618ArgVAR_006311rs76262710
4RETp.Cys618PheVAR_006312
5RETp.Cys618SerVAR_006313rs79781594
6RETp.Cys618TyrVAR_006314
7RETp.Cys620GlyVAR_006315
8RETp.Cys620ArgVAR_006316
9RETp.Cys620SerVAR_006317
10RETp.Cys620PheVAR_006318rs77503355
11RETp.Cys630PheVAR_006320
12RETp.Cys634TyrVAR_006325
13RETp.Cys634ArgVAR_006326
14RETp.Cys634SerVAR_006327
15RETp.Cys634TrpVAR_006328
16RETp.Glu768AspVAR_006335rs78014899
17RETp.Val804LeuVAR_006336rs79658334
18RETp.Val804MetVAR_006337rs79658334
19RETp.Met918ThrVAR_006342rs74799832
20RETp.Thr946MetVAR_006345
21RETp.Cys611GlyVAR_009472
22RETp.Cys630SerVAR_009477
23RETp.Cys630TyrVAR_009478
24RETp.Leu790PheVAR_009482rs75030001
25RETp.Tyr791PheVAR_009483rs77724903
26RETp.Ser891AlaVAR_009486rs75234356
27RETp.Arg844LeuVAR_011582rs55947360
28RETp.Ala639GlyVAR_012743
29RETp.Ala641GlyVAR_012744
30RETp.Ser922PheVAR_012745

Expression for genes affiliated with Familial Medullary Thyroid Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Medullary Thyroid Carcinoma

Search GEO for disease gene expression data for Familial Medullary Thyroid Carcinoma.

Pathways for genes affiliated with Familial Medullary Thyroid Carcinoma

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Sources:
53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG, 52R&D Systems, 59Tocris Bioscience, 49PharmGKB, 55SinoBiological
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Pathways related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6NTRK1, MAPK3
2
Hide members
9.4STAT3, NTRK1
39.3FOS, MAPK3
49.3FOS, MAPK3
59.3FOS, MAPK3
69.3FOS, MAPK3
7
Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
Hide members
9.3MAPK3, FOS
89.3MAPK3, FOS
9
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9.2SDHC, SDHB, SDHD
109.2SDHD, SDHB, SDHC
11
Hide members
9.2SDHD, SDHC, SDHB
12
Hide members
9.2SDHD, SDHB, SDHC
139.2NTRK1, RET, MAPK3
149.1FOS, STAT3
15
Hide members
9.0STAT3, MAPK3
169.0STAT3, MAPK3
17
Hide members
9.0MAPK3, NTRK1, FOS
189.0MAPK3, GDNF, RET
198.8GDNF, MAPK3, FOS
20
Hide members
8.7NTRK1, STAT3, MAPK3
218.7MAPK3, NTRK1, STAT3
22
Hide members
8.6SDHC, SDHD, MAPK3, SDHB
23
Hide members
8.5FOS, MAPK3, STAT3
24
Development PDGF signaling via STATs and NF-kB
Hide members
8.5STAT3, MAPK3, FOS
25
Hide members
8.5FOS, STAT3, MAPK3
26
Hide members
8.5STAT3, MAPK3, FOS
27
Hide members
8.5STAT3, FOS, MAPK3
28
Mucin expression in CF via IL-6, IL-17 signaling pathways
Hide members
8.5FOS, STAT3, MAPK3
298.5STAT3, MAPK3, FOS
30
Hide members
8.5STAT3, FOS, MAPK3
31
Immune response IL-6 signaling pathway
Hide members
8.5FOS, STAT3, MAPK3
32
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
8.5STAT3, MAPK3, FOS
33
Hide members
8.5STAT3, MAPK3, FOS
34
Hide members
8.5STAT3, MAPK3, FOS
358.5FOS, STAT3, MAPK3
36
Hide members
8.5MAPK3, STAT3, FOS
378.5MAPK3, STAT3, FOS
38
Hide members
8.5STAT3, MAPK3, FOS
398.5MAPK3, FOS, STAT3
408.5MAPK3, FOS, STAT3
41
Development Prolactin receptor signaling
Hide members
8.5MAPK3, FOS, STAT3
428.5MAPK3, FOS, STAT3
438.5MAPK3, FOS, STAT3
44
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
8.5MAPK3, FOS, STAT3
45
Hide members
8.2STAT3, NTRK1, MAPK3, FOS
468.2STAT3, NTRK1, MAPK3, FOS
47
Hide members
8.2NTRK1, MAPK3, FOS, STAT3
487.9RET, FOS, STAT3, NTRK1, MAPK3
49
Hide members
7.7MAPK3, FOS, STAT3, GDNF, NTRK1
50
Hide members
7.7STAT3, MAPK3, GDNF, RET, FOS

Compounds for genes affiliated with Familial Medullary Thyroid Carcinoma

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1cipa4410.2RET, NTRK1
2glutamate4410.0GDNF, NTRK1
3mibg449.7SDHD, SDHB, CALCA
4UBIQUINONE-1119.7SDHD, SDHB, SDHC
52-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol119.6SDHC, SDHD, SDHB
6fumarate44 1110.6SDHB, SDHD, SDHC
7iron-sulfur449.6SDHB, SDHD, SDHC
8succinic acid28 11 2411.6SDHC, SDHD, SDHB
9ubiquinone449.6SDHD, SDHC, SDHB
10succinate449.3SDHD, SDHB, RET, SDHC
11capsaicin44 2810.2CALCA, FOS, NTRK1, GDNF
12anisomycin44 1110.2STAT3, MAPK3
13forskolin44 49 1111.1GDNF, MAPK3, CALCA
14phorbol449.0FOS, MAPK3, NTRK1
15vanadate449.0NTRK1, MAPK3, STAT3
16catecholamine449.0RET, NTRK1, GDNF, SDHD, SDHB
17norepinephrine44 11 2410.8GDNF, SDHB, CALCA, MAPK3
18ag 1478448.7STAT3, FOS, MAPK3
19losartan44 49 28 1111.7FOS, MAPK3, STAT3
20nmda44 289.6GDNF, FOS, MAPK3, SDHB
21gp 130448.6STAT3, FOS, MAPK3
22tamoxifen44 49 28 1111.5MAPK3, NTRK1, STAT3, FOS
23agar448.5MAPK3, STAT3, FOS, RET
24dopamine44 28 11 2411.5FOS, SDHB, NTRK1, MAPK3, GDNF
25sp 60012544 599.4FOS, MAPK3, STAT3
26phosphotyrosine448.3FOS, RET, NTRK1, MAPK3, STAT3
27oligonucleotide448.3FOS, STAT3, NTRK1, GDNF, RET
2812-o-tetradecanoylphorbol 13-acetate448.3STAT3, RET, FOS, NTRK1, MAPK3
29cyclic amp44 249.3MAPK3, GDNF, NTRK1, FOS, CALCA, RET
30iron44 249.3STAT3, GDNF, SDHD, SDHC, SDHB
31arachidonic acid44 28 11 2411.2FOS, NTRK1, MAPK3, STAT3
32oxygen44 249.1GDNF, SDHD, SDHB, SDHC, NTRK1
33threonine448.1MAPK3, STAT3, FOS, NTRK1, RET
34phosphoinositide448.1FOS, GDNF, STAT3, NTRK1, MAPK3
35testosterone44 59 11 2411.0MAPK3, SDHB, RET, CALCA, STAT3, NTRK1
36aspartate447.9SDHB, RET, GDNF, MAPK3, NTRK1, STAT3
37alanine447.8STAT3, NTRK1, MAPK3, GDNF, RET, SDHB
38pd 98,059447.8FOS, RET, STAT3, NTRK1, MAPK3, GDNF
39ly294002447.8FOS, STAT3, NTRK1, GDNF, RET, MAPK3
40wortmannin447.8STAT3, GDNF, MAPK3, RET, NTRK1, FOS
41genistein44 28 59 2 11 2412.8MAPK3, NTRK1, RET, FOS, GDNF, STAT3
42atp44 288.8NTRK1, STAT3, MAPK3, GDNF, RET, SDHB
43cysteine447.8NTRK1, STAT3, RET, MAPK3, SDHB, GDNF
44phosphatidylinositol447.8NTRK1, MAPK3, GDNF, RET, FOS, STAT3
45calcium44 49 11 2410.7CALCA, RET, GDNF, MAPK3, NTRK1, FOS
46h2o2447.6GDNF, SDHB, NTRK1, STAT3, FOS, MAPK3
47serine447.5STAT3, NTRK1, FOS, GDNF, RET, MAPK3
48retinoic acid44 248.4NTRK1, GDNF, MAPK3, FOS, RET, SDHC
49tyrosine447.3STAT3, SDHB, RET, GDNF, FOS, NTRK1
50vegf446.6SDHC, FOS, STAT3, NTRK1, MAPK3, RET

GO Terms for genes affiliated with Familial Medullary Thyroid Carcinoma

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16Gene Ontology
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Cellular components related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:0057499.2SDHC, SDHB, SDHD

Biological processes related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1detection of temperature stimulus involved in sensory perception of painGO:05096510.1NTRK1, CALCA
2response to painGO:04826510.0CALCA, RET
3aerobic respirationGO:0090609.8SDHC, SDHB
4enteric nervous system developmentGO:0484849.8RET, GDNF
5sympathetic nervous system developmentGO:0484859.8GDNF, NTRK1
6agingGO:0075689.5CALCA, FOS, NTRK1
7activation of adenylate cyclase activityGO:0071909.5CALCA, NTRK1
8tricarboxylic acid cycleGO:0060999.5SDHC, SDHB, SDHD
9respiratory electron transport chainGO:0229049.5SDHC, SDHB, SDHD
10cellular metabolic processGO:0442379.5SDHC, SDHB, SDHD
11protein phosphorylationGO:0064689.2CALCA, NTRK1, MAPK3, RET
12cellular response to hormone stimulusGO:0328709.1FOS, STAT3
13JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.1STAT3, MAPK3
14phosphorylationGO:0163108.9MAPK3, STAT3
15positive regulation of transcription from RNA polymerase II promoterGO:0459448.0GDNF, MAPK3, STAT3, FOS

Molecular functions related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.9RET, NTRK1
2ubiquinone bindingGO:0480399.5SDHB, SDHD
3electron carrier activityGO:0090558.9SDHC, SDHB, SDHD

Products for genes affiliated with Familial Medullary Thyroid Carcinoma

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  • Antibodies
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Sources for Familial Medullary Thyroid Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet