MCID: FML010
MIFTS: 63

Familial Medullary Thyroid Carcinoma malady

Genetic diseases, Cancer diseases, Rare diseases, Gastrointestinal diseases, Endocrine diseases categories
Download this MalaCard

Summaries for Familial Medullary Thyroid Carcinoma

About this section


Fully expand this MalaCard
Wikipedia:65 The term multiple endocrine neoplasia (MEN) encompasses several distinct syndromes featuring tumors of... more...

MalaCards based summary: Familial Medullary Thyroid Carcinoma, also known as thyroid carcinoma, familial medullary, is related to hirschsprung's disease and pheochromocytoma, and has symptoms including An important gene associated with Familial Medullary Thyroid Carcinoma is NTRK1 (neurotrophic tyrosine kinase, receptor, type 1), and among its related pathways are EGF receptor (ErbB1) signaling pathway and Growth hormone receptor signaling. The compounds cipa and mibg have been mentioned in the context of this disorder. Affiliated tissues include thyroid and testes, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Description from OMIM:46 155240

Aliases & Classifications for Familial Medullary Thyroid Carcinoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 20GeneTests, 22GTR, 44Novoseek, 62UMLS, 46OMIM
See all sources

Familial Medullary Thyroid Carcinoma, Aliases & Descriptions:

Name: Familial Medullary Thyroid Carcinoma 8 10
Thyroid Carcinoma, Familial Medullary 8 20 22 44 62
 
Medullary Thyroid Carcinoma, Familial 46


Classifications:



External Ids:

Disease Ontology8 DOID:0050547
OMIM46 155240

Related Diseases for Familial Medullary Thyroid Carcinoma

About this section

Diseases in the Thyroid Medullary Carcinoma family:

familial medullary thyroid carcinoma Ntrk1-Related Familial Medullary Thyroid Carcinoma

Diseases related to Familial Medullary Thyroid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1hirschsprung's disease31.4GDNF, RET
2pheochromocytoma31.2SDHB, SDHD, RET
3multiple endocrine neoplasia31.0SDHD, SDHB, GDNF, SDHC, RET, CALCA
4parathyroid adenoma30.9RET, CALCA
5multiple endocrine neoplasia type 2a30.9CALCA, RET, SDHC, SDHD, SDHB, GDNF
6thyroid medullary carcinoma30.6GDNF, RET, NTRK1, CALCA
7papillary thyroid carcinoma30.6NTRK1, STAT3, RET
8phaeochromocytoma30.5SDHB, SDHD, SDHC, RET, CALCA
9adenoma30.1GDNF, RET, NTRK1, MAPK3, CALCA
10thyroiditis11.3
11cowden disease10.5RET
12amyloidosis10.5
13central hypoventilation syndrome10.5GDNF
14ntrk1-related familial medullary thyroid carcinoma10.4
15lichen amyloidosis10.4
16pancreatic islet cell tumors10.4RET, CALCA
17autosomal dominant disease10.4CALCA, RET
18nodular goiter10.4CALCA, RET
19renal dysplasia10.4GDNF, RET
20paragangliomas 110.4RET, SDHB
21follicular thyroid carcinoma10.4RET, CALCA
22hypoparathyroidism10.4RET, CALCA
23primary hyperparathyroidism10.3CALCA, RET
24intestinal obstruction10.3GDNF, RET
25hypothyroidism10.3RET, CALCA
26renal agenesis10.3RET, GDNF
27neurofibromatosis10.3SDHD, SDHB
28goiter10.3CALCA, RET
29paraganglioma10.3SDHB, SDHD
30thyroid cancer, anaplastic10.3CALCA, RET
31sipple syndrome10.3
32diabetic neuropathy10.3NTRK1, GDNF
33ganglioneuroma10.2NTRK1, RET
34neuroma10.2GDNF, RET, CALCA
35carcinoid syndrome10.2SDHD, RET, CALCA
36familial colorectal cancer10.2RET, SDHD, SDHB
37brain ischemia10.2GDNF, MAPK3
38autoimmune thyroiditis10.2CALCA, RET
39cushing's syndrome10.2CALCA, RET
40follicular adenoma10.2RET, NTRK1, CALCA
41papillary carcinoma10.2RET, NTRK1, CALCA
42thyroid hurthle cell carcinoma10.2CALCA, NTRK1, RET
43hereditary paraganglioma-pheochromocytoma syndromes10.2SDHC, SDHD, SDHB
44paraganglioma and gastric stromal sarcoma10.2SDHB, SDHD, SDHC
45carotid body tumor10.2SDHC, SDHD, SDHB
46carney triad10.2SDHB, SDHD, SDHC
47chondroma10.1SDHC, SDHD, SDHB
48adrenal cortical adenoma10.1SDHC, SDHD, SDHB
49pain agnosia10.1CALCA, FOS
50immunodeficiency with hyper igm type 210.1NTRK1, SDHB, GDNF

Graphical network of the top 20 diseases related to Familial Medullary Thyroid Carcinoma:



Diseases related to familial medullary thyroid carcinoma

Symptoms for Familial Medullary Thyroid Carcinoma

About this section

Symptoms by clinical synopsis from OMIM:

155240

Clinical features from OMIM:

155240

HPO human phenotypes related to Familial Medullary Thyroid Carcinoma:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 medullary thyroid carcinoma HP:0002865

Drugs & Therapeutics for Familial Medullary Thyroid Carcinoma

About this section

Drug clinical trials:

Search ClinicalTrials for Familial Medullary Thyroid Carcinoma

Search NIH Clinical Center for Familial Medullary Thyroid Carcinoma

Genetic Tests for Familial Medullary Thyroid Carcinoma

About this section

Genetic tests related to Familial Medullary Thyroid Carcinoma:

id Genetic test Affiliating Genes
1 Familial Medullary Thyroid Carcinoma20 22

Anatomical Context for Familial Medullary Thyroid Carcinoma

About this section

MalaCards organs/tissues related to Familial Medullary Thyroid Carcinoma:

32
Thyroid, Testes

Animal Models for Familial Medullary Thyroid Carcinoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Familial Medullary Thyroid Carcinoma:

36 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5GDNF, RET, STAT3, NTRK1, MAPK3
2MP:00053798.1GDNF, SDHD, RET, STAT3, FOS
3MP:00053858.1GDNF, SDHD, RET, STAT3, MAPK3, CALCA
4MP:00028738.0SDHD, RET, STAT3, FOS, NTRK1, CALCA
5MP:00107717.9STAT3, FOS, NTRK1, MAPK3, CALCA
6MP:00053807.8SDHD, RET, STAT3, FOS, CALCA
7MP:00020067.7SDHD, RET, STAT3, FOS, MAPK3, CALCA
8MP:00053977.6GDNF, RET, STAT3, FOS, NTRK1, MAPK3
9MP:00053877.6GDNF, RET, STAT3, FOS, NTRK1, MAPK3
10MP:00053767.5CALCA, MAPK3, FOS, STAT3, RET, SDHD
11MP:00053787.3GDNF, SDHD, RET, STAT3, FOS, NTRK1
12MP:00053847.3GDNF, SDHD, RET, STAT3, FOS, MAPK3
13MP:00053867.0GDNF, SDHD, RET, STAT3, FOS, NTRK1
14MP:00036317.0GDNF, SDHD, RET, STAT3, FOS, NTRK1
15MP:00107686.5CALCA, GDNF, SDHD, SDHC, RET, STAT3

Publications for Familial Medullary Thyroid Carcinoma

About this section

Articles related to Familial Medullary Thyroid Carcinoma:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
The rare intracellular RET mutation p.S891A in a Chinese Han family with familial medullary thyroid carcinoma. (24845513)
2014
2
Role of prophylactic thyroidectomy in RET 790 familial medullary thyroid carcinoma. (21688339)
2012
3
Case report: a p.C618S RET proto-oncogene germline mutation in a large Chinese pedigree with familial medullary thyroid carcinoma. (22068382)
2012
4
New presentation of familial medullary thyroid carcinoma in 87-year-old patient with high-risk RET proto-oncogene codon 620 mutation. (18771606)
2009
5
Familial medullary thyroid carcinoma associated with cutaneous lichen amyloidosis. (19445625)
2009
6
Prophylactic thyroidectomy in pediatric carriers of multiple endocrine neoplasia type 2A or familial medullary thyroid carcinoma: mutation in C620 is associated with Hirschsprung's disease. (17208566)
2007
7
Clinical case seminar: in vivo and in vitro characterization of a novel germline RET mutation associated with low-penetrant nonaggressive familial medullary thyroid carcinoma. (16384843)
2006
8
A rare RET gene exon 8 mutation is found in two Greek kindreds with familial medullary thyroid carcinoma: implications for screening. (16649977)
2006
9
A novel Czech kindred with familial medullary thyroid carcinoma and Hirschsprung's disease. (15991157)
2005
10
Exon 5 of the RET proto-oncogene: a newly detected risk exon for familial medullary thyroid carcinoma, a novel germ-line mutation Gly321Arg. (16419493)
2005
11
No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinoma. (16322339)
2005
12
Timing and extent of surgery in patients with familial medullary thyroid carcinoma/multiple endocrine neoplasia 2A-related RET mutations not affecting codon 634. (15517481)
2004
13
A novel germ-line point mutation in RET exon 8 (Gly(533)Cys) in a large kindred with familial medullary thyroid carcinoma. (14602786)
2003
14
Study of RET protooncogene in multiple endocrine neoplasm 2A and in familial medullary thyroid carcinoma. Clinical pathological findings in asymptomatic carriers]. (12673960)
2003
15
When should thyroidectomy be performed in familial medullary thyroid carcinoma gene carriers with non-cysteine RET mutations? (14668737)
2003
16
A new identified germline mutation of the RET proto-oncogene responsible for familial medullary thyroid carcinoma in co-existence with a hyperfunctioning autonomous nodule. (12072055)
2002
17
Familial medullary thyroid carcinoma (FMTC). Study of one family (treatment criteria). (11289752)
2001
18
Molecular genetic diagnostic program of multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma syndromes in Hungary. (11524247)
2001
19
Familial medullary thyroid carcinoma and prominent corneal nerves associated with the germline V804M and V778I mutations on the same allele of RET. (11732489)
2001
20
Presentation of a kindred with familial medullary thyroid carcinoma and Cys611Phe mutation of the RET proto-oncogene demonstrating low grade malignancy. (11331212)
2001
21
Incidental detection of familial medullary thyroid carcinoma by calcitonin screening for nodular thyroid disease. (10474127)
1999
22
Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma. (10445857)
1999
23
Prognosis of a family with familial medullary thyroid carcinoma. (10464711)
1999
24
Psychosocial impact of genetic testing in familial medullary-thyroid carcinoma: a multicentric pilot-evaluation. (10076727)
1999
25
A GTG to ATG novel point mutation at codon 804 in exon 14 of the RET proto-oncogene in two families affected by familial medullary thyroid carcinoma. (9452077)
1998
26
Results of the calcitonin stimulation test in normal volunteers compared with genetically unaffected members of MEN 2A and familial medullary thyroid carcinoma families. (9436479)
1997
27
Biological properties of Ret with cysteine mutations correlate with multiple endocrine neoplasia type 2A, familial medullary thyroid carcinoma, and Hirschsprung's disease phenotype. (9230192)
1997
28
Prevalence and parental origin of de novo RET mutations in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma. Le Groupe d'Etude des Tumeurs a Calcitonine. (8981969)
1997
29
A novel somatic mutation in the RET proto-oncogene in familial medullary thyroid carcinoma with a germline codon 768 mutation. (9263528)
1997
30
Cys 618 Arg mutation in the RET proto-oncogene associated with familial medullary thyroid carcinoma and maternally transmitted Hirschsprung's disease suggesting a role for imprinting. (9259198)
1997
31
Familial medullary thyroid carcinoma: not a distinct entity? Genotype-phenotype correlation in a large family. (9003111)
1996
32
Immune response against medullary thyroid carcinoma (MTC) induced by parental and/or interleukin-2-secreting MTC cells in a rat model of human familial medullary thyroid carcinoma. (8954146)
1996
33
Rudolf-Virchow-Preis 1995. The role of RET proto-oncogene mutation analysis in the diagnosis of multiple endocrine neoplasia type 2 (MEN 2) gene carriers and in the discrimination of sporadic and familial medullary thyroid carcinomas and pheochromocytomas. (8600671)
1995
34
Multiple endocrine neoplasia type 2A, type 2B and familial medullary thyroid carcinoma syndrome]. (8538031)
1995
35
A rapid screening method for the detection of mutations in the RET proto-oncogene in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma families. (7835899)
1994
36
Mapping the inherited defects associated with multiple endocrine neoplasia type 2A, multiple endocrine neoplasia type 2B, and familial medullary thyroid carcinoma to chromosome 10 by linkage analysis. (7913024)
1994
37
Familial medullary thyroid carcinoma: report of three cases in a family. (8099830)
1993
38
Familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2B map to the same region of chromosome 10 as multiple endocrine neoplasia type 2A. (1672289)
1991
39
Incidence of sporadic and familial medullary thyroid carcinoma in Sweden 1959 through 1981. A nationwide study in 126 patients. Swedish MCT Study Group. (2310607)
1990
40
Clinical characteristics in sporadic and familial medullary thyroid carcinoma. A nationwide study of 249 patients in Sweden from 1959 through 1981. (2563669)
1989
41
Familial medullary thyroid carcinoma without associated endocrinopathies: a distinct clinical entity. (3697657)
1986
42
Diagnostic usefulness of the calcitonin secretion induced with pentagastrin in the familial medullary thyroid carcinoma. (2870690)
1985
43
Screening for familial medullary thyroid carcinoma: a review. (6747984)
1984
44
Gastrin Responses to a test meal in patients with familial medullary thyroid carcinoma. (7061688)
1982
45
Familial medullary thyroid carcinoma and C cell hyperplasia. (7285384)
1981
46
Natural history of familial medullary thyroid carcinoma: effect of a program for early diagnosis. (692625)
1978
47
Cellular immune responses in familial medullary thyroid carcinoma. (321956)
1977
48
Natural history of the familial medullary thyroid carcinoma-pheochromocytoma syndrome and the identification of preneoplastic stages by screening studies: a five-year report. (1224435)
1975
49
Familial medullary thyroid carcinoma and pheochromocytoma: epidemiologic investigations. (4359415)
1974
50
Studies in familial (medullary) thyroid carcinoma. (4347303)
1972

Variations for Familial Medullary Thyroid Carcinoma

About this section

UniProtKB/Swiss-Prot genetic disease variations for Familial Medullary Thyroid Carcinoma:

64 (show all 30)
id Symbol AA change Variation ID SNP ID
1RETp.Cys609TyrVAR_006306rs77939446
2RETp.Cys611TrpVAR_006308rs80069458
3RETp.Cys618ArgVAR_006311rs76262710
4RETp.Cys618PheVAR_006312
5RETp.Cys618SerVAR_006313rs79781594
6RETp.Cys618TyrVAR_006314
7RETp.Cys620GlyVAR_006315
8RETp.Cys620ArgVAR_006316
9RETp.Cys620SerVAR_006317
10RETp.Cys620PheVAR_006318rs77503355
11RETp.Cys630PheVAR_006320
12RETp.Cys634TyrVAR_006325
13RETp.Cys634ArgVAR_006326
14RETp.Cys634SerVAR_006327
15RETp.Cys634TrpVAR_006328
16RETp.Glu768AspVAR_006335rs78014899
17RETp.Val804LeuVAR_006336rs79658334
18RETp.Val804MetVAR_006337rs79658334
19RETp.Met918ThrVAR_006342rs74799832
20RETp.Thr946MetVAR_006345
21RETp.Cys611GlyVAR_009472
22RETp.Cys630SerVAR_009477
23RETp.Cys630TyrVAR_009478
24RETp.Leu790PheVAR_009482rs75030001
25RETp.Tyr791PheVAR_009483rs77724903
26RETp.Ser891AlaVAR_009486rs75234356
27RETp.Arg844LeuVAR_011582rs55947360
28RETp.Ala639GlyVAR_012743
29RETp.Ala641GlyVAR_012744
30RETp.Ser922PheVAR_012745

Clinvar genetic disease variations for Familial Medullary Thyroid Carcinoma:

6 (show all 16)
id Gene Name Type Significance SNP ID Assembly Location
1NTRK1NM_001007792.1(NTRK1): c.1730G> T (p.Gly577Val)single nucleotide variantPathogenicrs6339GRCh37Chr 1, 156848946: 156848946
2NTRK1NM_001007792.1(NTRK1): c.1730G> T (p.Gly577Val)single nucleotide variantPathogenicrs6339GRCh37Chr 1, 156848946: 156848946
3RETNM_020975.4(RET): c.1901G> T (p.Cys634Phe)single nucleotide variantPathogenicrs75996173GRCh37Chr 10, 43609949: 43609949
4RETNM_020975.4(RET): c.1853G> C (p.Cys618Ser)single nucleotide variantPathogenicrs79781594GRCh37Chr 10, 43609097: 43609097
5RETNM_020975.4(RET): c.1852T> C (p.Cys618Arg)single nucleotide variantPathogenicrs76262710GRCh37Chr 10, 43609096: 43609096
6RETNM_020975.4(RET): c.2304G> C (p.Glu768Asp)single nucleotide variantPathogenicrs78014899GRCh37Chr 10, 43613840: 43613840
7RETNM_020975.4(RET): c.2370G> C (p.Leu790Phe)single nucleotide variantPathogenicrs75030001GRCh37Chr 10, 43613906: 43613906
8RETRET, 9-BP DUP, EX8duplicationPathogenic
9RETNM_020975.4(RET): c.1859G> C (p.Cys620Ser)single nucleotide variantPathogenicrs77503355GRCh37Chr 10, 43609103: 43609103
10RETNM_020975.4(RET): c.1825T> C (p.Cys609Arg)single nucleotide variantPathogenicrs77558292GRCh37Chr 10, 43609069: 43609069
11RETNM_020975.4(RET): c.2410G> T (p.Val804Leu)single nucleotide variantPathogenicrs79658334GRCh37Chr 10, 43614996: 43614996
12RETNM_020975.4(RET): c.1597G> T (p.Gly533Cys)single nucleotide variantPathogenicrs75873440GRCh37Chr 10, 43607621: 43607621
13RETNM_020975.4(RET): c.2671T> G (p.Ser891Ala)single nucleotide variantPathogenicrs75234356GRCh37Chr 10, 43615592: 43615592
14RETNM_020975.4(RET): c.1585_1593dupGAGGAGTGT (p.Cys531_Gly532insGluGluCys)duplicationPathogenicrs377767434GRCh37Chr 10, 43607609: 43607617
15RETNM_020975.4(RET): c.2735G> C (p.Arg912Pro)single nucleotide variantPathogenicrs78347871GRCh37Chr 10, 43617398: 43617398
16NTRK1NM_001007792.1(NTRK1): c.1702C> T (p.His568Tyr)single nucleotide variantPathogenicrs6336GRCh37Chr 1, 156848918: 156848918

Expression for genes affiliated with Familial Medullary Thyroid Carcinoma

About this section
Expression patterns in normal tissues for genes affiliated with Familial Medullary Thyroid Carcinoma

Search GEO for disease gene expression data for Familial Medullary Thyroid Carcinoma.

Pathways for genes affiliated with Familial Medullary Thyroid Carcinoma

About this section

Pathways related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3STAT3, MAPK3
29.3MAPK3, STAT3
39.2RET, NTRK1, MAPK3
49.1FOS, STAT3
5
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
9.1SDHC, SDHD, SDHB
6
Show member pathways
TCA cycle37
pyruvate decarboxylation to acetyl CoA37
NAD phosphorylation and dephosphorylation37
TCA Cycle37
conversion of glucose to acetyl CoA and entry into the TCA cycle37
9.1SDHC, SDHD, SDHB
79.1GDNF, RET, MAPK3
89.0MAPK3, FOS
99.0MAPK3, FOS
109.0FOS, MAPK3
119.0MAPK3, FOS
12
Show member pathways
9.0MAPK3, NTRK1, STAT3
13
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.7MAPK3, NTRK1, FOS
14
Show member pathways
8.7MAPK3, NTRK1, FOS
158.6MAPK3, FOS, GDNF
16
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.5MAPK3, FOS, STAT3
17
Show member pathways
8.5MAPK3, FOS, STAT3
18
Show member pathways
Signal transduction PTEN pathway60
8.5STAT3, FOS, MAPK3
19
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
8.5STAT3, FOS, MAPK3
20
Show member pathways
8.5MAPK3, FOS, STAT3
21
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
8.5STAT3, FOS, MAPK3
228.5STAT3, FOS, MAPK3
23
Show member pathways
8.5MAPK3, FOS, STAT3
24
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.5MAPK3, FOS, STAT3
25
Show member pathways
8.5MAPK3, FOS, STAT3
26
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
8.5STAT3, FOS, MAPK3
278.5STAT3, FOS, MAPK3
28
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
8.5MAPK3, FOS, STAT3
298.5MAPK3, FOS, STAT3
30
Show member pathways
8.5STAT3, FOS, MAPK3
318.5STAT3, FOS, MAPK3
32
Show member pathways
8.5MAPK3, FOS, STAT3
338.5MAPK3, FOS, STAT3
348.5STAT3, FOS, MAPK3
35
Show member pathways
IL-2 Signaling pathway37
8.5MAPK3, FOS, STAT3
36
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
8.5STAT3, FOS, MAPK3
37
Show member pathways
8.5STAT3, FOS, MAPK3
38
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
8.5MAPK3, FOS, STAT3
398.5STAT3, FOS, MAPK3
40
Show member pathways
8.5STAT3, FOS, MAPK3
41
Show member pathways
Alzheimers Disease37
8.5SDHB, SDHD, SDHC, MAPK3
42
Show member pathways
8.2STAT3, FOS, NTRK1, MAPK3
438.2STAT3, FOS, NTRK1, MAPK3
44
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.2STAT3, FOS, NTRK1, MAPK3
45
Show member pathways
8.2MAPK3, NTRK1, FOS, STAT3
46
Show member pathways
8.2MAPK3, NTRK1, FOS, STAT3
47
Show member pathways
8.2MAPK3, NTRK1, FOS, STAT3
487.9RET, STAT3, FOS, NTRK1, MAPK3
49
Show member pathways
7.8MAPK3, NTRK1, FOS, STAT3, GDNF
50
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
7.8MAPK3, FOS, STAT3, RET, GDNF

Compounds for genes affiliated with Familial Medullary Thyroid Carcinoma

About this section

Compounds related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1cipa4410.2NTRK1, RET
2mibg449.7SDHB, SDHD, CALCA
3Fumaric acid249.6SDHB, SDHC, SDHD
4fumarate44 1110.5SDHB, SDHD, SDHC
5succinic acid28 24 1111.5SDHB, SDHC, SDHD
6iron-sulfur449.5SDHC, SDHD, SDHB
7ubiquinone449.5SDHC, SDHD, SDHB
8Sulfide249.4SDHD, SDHB, SDHC
9QH2249.4SDHC, SDHB, SDHD
10Ubiquinone Q2249.4SDHD, SDHC, SDHB
11Ubiquinone Q1249.3SDHD, SDHC, SDHB
12succinate449.2SDHD, RET, SDHC, SDHB
13vanadate449.1MAPK3, STAT3, NTRK1
14catecholamine449.1GDNF, SDHB, SDHD, RET, NTRK1
15capsaicin44 2810.0CALCA, NTRK1, FOS, GDNF
16norepinephrine44 24 1110.8CALCA, MAPK3, SDHB, GDNF
17butyrate448.7MAPK3, RET, FOS, NTRK1
18iron44 249.6STAT3, SDHC, SDHD, SDHB, GDNF
19agar448.5RET, MAPK3, STAT3, FOS
20ag 1478448.5STAT3, MAPK3, FOS
21tamoxifen44 50 28 1111.4MAPK3, FOS, STAT3, NTRK1
22oxygen44 249.4SDHB, GDNF, NTRK1, SDHC, SDHD
23losartan44 50 28 1111.4MAPK3, FOS, STAT3
24oligonucleotide448.4NTRK1, STAT3, FOS, RET, GDNF
25nmda44 289.4GDNF, MAPK3, SDHB, FOS
26testosterone44 61 24 1111.3CALCA, MAPK3, NTRK1, RET, STAT3, SDHB
27phosphotyrosine448.3MAPK3, NTRK1, FOS, STAT3, RET
2812-o-tetradecanoylphorbol 13-acetate448.3NTRK1, FOS, STAT3, RET, MAPK3
29aspartate448.3RET, SDHB, STAT3, MAPK3, GDNF, NTRK1
30alanine448.2NTRK1, MAPK3, GDNF, SDHB, RET, STAT3
31anisomycin44 119.2FOS, STAT3, MAPK3
32atp44 289.2MAPK3, RET, GDNF, NTRK1, SDHB, STAT3
33cysteine448.2GDNF, SDHB, NTRK1, STAT3, RET, MAPK3
34phosphoinositide448.2MAPK3, NTRK1, FOS, STAT3, GDNF
35cyclic amp44 249.1FOS, RET, NTRK1, MAPK3, CALCA, GDNF
36threonine448.1MAPK3, RET, NTRK1, STAT3, FOS
37pd 98,059447.9GDNF, MAPK3, NTRK1, RET, FOS, STAT3
38ly294002447.9FOS, RET, STAT3, NTRK1, MAPK3, GDNF
39wortmannin447.9MAPK3, NTRK1, FOS, STAT3, GDNF, RET
40glutamate447.9SDHB, FOS, MAPK3, CALCA, NTRK1, GDNF
41genistein44 28 61 2 24 1112.9GDNF, MAPK3, RET, FOS, NTRK1, STAT3
42phosphatidylinositol447.9GDNF, RET, MAPK3, NTRK1, FOS, STAT3
43estrogen447.8CALCA, MAPK3, STAT3, FOS, NTRK1, GDNF
44h2o2447.8GDNF, SDHB, FOS, NTRK1, MAPK3, STAT3
45dopamine44 28 24 1110.6GDNF, SDHB, RET, MAPK3, CALCA, FOS
46serine447.6FOS, RET, NTRK1, MAPK3, GDNF, STAT3
47calcium44 50 24 1110.5GDNF, RET, SDHB, FOS, NTRK1, MAPK3
48tyrosine447.4MAPK3, GDNF, FOS, STAT3, RET, SDHB
49retinoic acid44 248.4RET, SDHC, NTRK1, GDNF, FOS, STAT3
50vegf446.6CALCA, GDNF, SDHB, SDHC, RET, STAT3

GO Terms for genes affiliated with Familial Medullary Thyroid Carcinoma

About this section

Cellular components related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial inner membraneGO:0057439.1SDHC, SDHD, SDHB
2mitochondrial respiratory chain complex IIGO:0057498.8SDHC, SDHD, SDHB

Biological processes related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1detection of temperature stimulus involved in sensory perception of painGO:05096510.2NTRK1, CALCA
2response to painGO:04826510.1RET, CALCA
3enteric nervous system developmentGO:04848410.0RET, GDNF
4sympathetic nervous system developmentGO:04848510.0GDNF, NTRK1
5activation of adenylate cyclase activityGO:00719010.0CALCA, NTRK1
6neural crest cell migrationGO:0017559.8RET, GDNF
7aerobic respirationGO:0090609.8SDHC, SDHB
8JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.6MAPK3, STAT3
9phosphorylationGO:0163109.6STAT3, MAPK3
10tricarboxylic acid cycleGO:0060999.5SDHC, SDHD, SDHB
11respiratory electron transport chainGO:0229049.5SDHC, SDHD, SDHB
12cellular metabolic processGO:0442379.4SDHC, SDHD, SDHB
13cellular response to hormone stimulusGO:0328709.3FOS, STAT3
14agingGO:0075689.3CALCA, NTRK1, FOS
15activation of MAPKK activityGO:0001869.3MAPK3, NTRK1
16protein phosphorylationGO:0064689.2RET, NTRK1, MAPK3, CALCA
17neurotrophin TRK receptor signaling pathwayGO:0480119.2STAT3, NTRK1, MAPK3
18axon guidanceGO:0074119.0MAPK3, NTRK1, GDNF
19regulation of sequence-specific DNA binding transcription factor activityGO:0510909.0FOS, MAPK3
20stress-activated MAPK cascadeGO:0514039.0MAPK3, FOS
21response to drugGO:0424938.9NTRK1, FOS, STAT3, RET
22nervous system developmentGO:0073998.8FOS, STAT3, GDNF
23positive regulation of transcription from RNA polymerase II promoterGO:0459448.3MAPK3, FOS, STAT3, GDNF

Molecular functions related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.9NTRK1, RET
2succinate dehydrogenase activityGO:0001049.6SDHC, SDHD
3ubiquinone bindingGO:0480399.5SDHD, SDHB
4electron carrier activityGO:0090558.8SDHC, SDHD, SDHB

Products for genes affiliated with Familial Medullary Thyroid Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Familial Medullary Thyroid Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet