MCID: FML010
MIFTS: 62

Familial Medullary Thyroid Carcinoma malady

Cancer diseases, Genetic diseases categories

Summaries for Familial Medullary Thyroid Carcinoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 The term multiple endocrine neoplasia (MEN) encompasses several distinct syndromes featuring tumors of... more...

MalaCards: Familial Medullary Thyroid Carcinoma, also known as thyroid carcinoma, familial medullary, is related to thyroiditis and thyroid medullary carcinoma. An important gene associated with Familial Medullary Thyroid Carcinoma is NTRK1 (neurotrophic tyrosine kinase, receptor, type 1), and among its related pathways are ARMS-mediated activation and TRKA activation by NGF. The compounds cipa and glutamate have been mentioned in the context of this disorder. Affiliated tissues include thyroid and testes, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Description from OMIM:46 155240

Aliases & Classifications for Familial Medullary Thyroid Carcinoma

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8Disease Ontology, 20GeneTests, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases


Aliases & Descriptions:

familial medullary thyroid carcinoma 8 10
thyroid carcinoma, familial medullary 8 20 22 44 60
medullary thyroid carcinoma, familial 46


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Disease Ontology8 DOID:0050547
OMIM46 155240

Related Diseases for Familial Medullary Thyroid Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Thyroid Medullary Carcinoma family:

familial medullary thyroid carcinoma Ntrk1-Related Familial Medullary Thyroid Carcinoma

Diseases related to Familial Medullary Thyroid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.8CALCA
2thyroid medullary carcinoma31.8CALCA, NTRK1, GDNF, RET
3pheochromocytoma30.7RET, SDHD, SDHB
4hirschsprung's disease30.7NTRK1, GDNF, RET
5papillary carcinoma30.5RET, NTRK1, CALCA
6papillary thyroid carcinoma30.5STAT3, NTRK1, RET
7phaeochromocytoma30.5SDHB, SDHD, RET, CALCA, SDHC
8parathyroid carcinoma30.3RET
9follicular thyroid carcinoma30.3CALCA, RET
10adenoma30.3CALCA, NTRK1, MAPK3, GDNF, RET
11amyloidosis10.5
12ntrk1-related familial medullary thyroid carcinoma10.4
13sipple syndrome10.2
14primary cutaneous amyloidosis10.2
15adrenal carcinoma10.2
16parathyroid adenoma10.2
17transitional cell carcinoma10.2
18neuroendocrine tumor10.0CALCA
19insulinoma10.0CALCA
20leprosy10.0SDHD
21hypertension10.0CALCA
22sarcoma10.0NTRK1
23neuroblastoma10.0NTRK1
24primary hyperoxaluria10.0FOS
25rhabdomyosarcoma10.0NTRK1
26central hypoventilation syndrome10.0GDNF
27asthma10.0FOS
28thymoma10.0NTRK1
29paragangliomas 110.0RET, SDHB
30nodular goiter10.0RET, CALCA
31chagas disease10.0NTRK1
32pituitary adenoma10.0GDNF, RET
33obesity10.0STAT3
34neurofibromatosis10.0SDHB, SDHD
35parkinson's disease10.0GDNF, FOS
36primary hyperparathyroidism10.0RET, CALCA
37amyotrophic lateral sclerosis10.0GDNF, NTRK1
38insulin resistance10.0FOS
39glomus tumor10.0SDHD, SDHB
40carcinoid syndrome10.0SDHD, RET, CALCA
41familial colorectal cancer10.0RET, SDHD, SDHB
42toxic encephalopathy10.0GDNF, FOS
43osteoarthritis10.0NTRK1, CALCA
44hereditary paraganglioma-pheochromocytoma syndromes10.0SDHC, SDHB, SDHD
45paraganglioma and gastric stromal sarcoma10.0SDHD, SDHB, SDHC
46carotid body tumor10.0SDHD, SDHB, SDHC
47diabetic neuropathy10.0NTRK1, GDNF
48carney triad10.0SDHD, SDHB, SDHC
49intestinal obstruction10.0RET, GDNF
50chondroma10.0SDHD, SDHB, SDHC

Graphical network of the top 20 diseases related to Familial Medullary Thyroid Carcinoma:



Diseases related to familial medullary thyroid carcinoma

Clinical Features for Familial Medullary Thyroid Carcinoma

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46OMIM
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Clinical features from OMIM:

155240

Clinical synopsis from OMIM:

155240

Drugs & Therapeutics for Familial Medullary Thyroid Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Familial Medullary Thyroid Carcinoma

Drug clinical trials:

Search ClinicalTrials for Familial Medullary Thyroid Carcinoma

Search NIH Clinical Center for Familial Medullary Thyroid Carcinoma

Search CenterWatch for Familial Medullary Thyroid Carcinoma

Genetic Tests for Familial Medullary Thyroid Carcinoma

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20GeneTests, 22GTR
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Genetic tests related to Familial Medullary Thyroid Carcinoma:

id Genetic test Affiliating Genes
1 Familial Medullary Thyroid Carcinoma20 22

Anatomical Context for Familial Medullary Thyroid Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Familial Medullary Thyroid Carcinoma:

32
Thyroid, Testes

Animal Models for Familial Medullary Thyroid Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Familial Medullary Thyroid Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6NTRK1, MAPK3, GDNF, RET
2MP:00053798.3RET, GDNF, STAT3, FOS
3MP:00028737.9CALCA, FOS, STAT3, NTRK1, RET, SDHD
4MP:00036317.8FOS, STAT3, NTRK1, GDNF, RET, SDHD
5MP:00020067.7SDHD, CALCA, FOS, STAT3, MAPK3, RET
6MP:00053857.5CALCA, STAT3, MAPK3, GDNF, RET, SDHD
7MP:00053977.1FOS, STAT3, NTRK1, MAPK3, GDNF, RET
8MP:00053787.1FOS, STAT3, NTRK1, MAPK3, GDNF, RET
9MP:00053866.8CALCA, FOS, STAT3, NTRK1, MAPK3, GDNF
10MP:00107686.4CALCA, FOS, STAT3, NTRK1, MAPK3, GDNF

Publications for Familial Medullary Thyroid Carcinoma

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50PubMed
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Articles related to Familial Medullary Thyroid Carcinoma:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
RET codon 618 mutations in Saudi families with multiple endocrine neoplasia Type 2A and familial medullary thyroid carcinoma. (23563004)
2013
2
Familial associations in medullary thyroid carcinoma with Hirschsprung disease: the role of the RET-C620 "Janus" genetic variation. (20152359)
2010
3
New presentation of familial medullary thyroid carcinoma in 87-year-old patient with high-risk RET proto-oncogene codon 620 mutation. (18771606)
2009
4
Multiple endocrine neoplasia type 2A in two families with the familial medullary thyroid carcinoma associated G533C mutation of the RET proto-oncogene. (18805915)
2008
5
A new germline point mutation in Ret exon 8 (cys515ser) in a family with medullary thyroid carcinoma. (18631007)
2008
6
Clinical case seminar: in vivo and in vitro characterization of a novel germline RET mutation associated with low-penetrant nonaggressive familial medullary thyroid carcinoma. (16384843)
2006
7
An in-frame complex germline mutation in the juxtamembrane intracellular domain causing RET activation in familial medullary thyroid carcinoma. (16954442)
2006
8
Late-onset medullary carcinoma of the thyroid: need for genetic testing and prophylactic thyroidectomy in adult family members. (16955009)
2006
9
Current approaches to medullary thyroid carcinoma, sporadic and familial. (17131404)
2006
10
RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor. (15753368)
2005
11
Screening of six risk exons of the RET proto-oncogene in families with medullary thyroid carcinoma in the Czech Republic. (15531714)
2004
12
The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma. (15277225)
2004
13
Clinical manifestations of familial medullary thyroid carcinoma. (15271414)
2004
14
A novel germ-line point mutation in RET exon 8 (Gly(533)Cys) in a large kindred with familial medullary thyroid carcinoma. (14602786)
2003
15
Penetrance of inherited medullary thyroid carcinoma and genotype-phenotype correlation in a large multiple endocrine neoplasia type 2A family with C634Y RET mutation. (12746565)
2003
16
Genome-wide copy number imbalances identified in familial and sporadic medullary thyroid carcinoma. (12679485)
2003
17
A new identified germline mutation of the RET proto-oncogene responsible for familial medullary thyroid carcinoma in co-existence with a hyperfunctioning autonomous nodule. (12072055)
2002
18
Familial medullary thyroid carcinoma: clinical variability and low aggressiveness associated with RET mutation at codon 804. (11932300)
2002
19
V804M RET mutation and familial medullary thyroid carcinoma: report of a large family with expression of the disease only in the homozygous gene carriers. (12019403)
2002
20
Presentation of a kindred with familial medullary thyroid carcinoma and Cys611Phe mutation of the RET proto-oncogene demonstrating low grade malignancy. (11331212)
2001
21
Diagnosis and therapy of sporadic and familial medullary thyroid carcinoma. (11260860)
2001
22
From gene to disease; from the RET gene to multiple endocrine neoplasia types 2A and 2B, sporadic and familial medullary thyroid carcinoma, Hirschsprung disease and papillary thyroid carcinoma]. (11757244)
2001
23
Is thyroidectomy necessary in RET mutations carriers of the familial medullary thyroid carcinoma syndrome? (10951350)
2000
24
Variable expressivity of familial medullary thyroid carcinoma (FMTC) due to a RET V804M (GTG-->ATG) mutation. (10876191)
2000
25
Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma. (10445857)
1999
26
A novel 9-base pair duplication in RET exon 8 in familial medullary thyroid carcinoma. (10323403)
1999
27
A codon 891 exon 15 RET proto-oncogene mutation in familial medullary thyroid carcinoma: a detection strategy. (10024437)
1999
28
Germ line mutation analysis in families with multiple endocrine neoplasia type 2A or familial medullary thyroid carcinoma. (9820617)
1998
29
Does the syndrome of familial medullary thyroid carcinoma describe a distinct clinical entity? (9893644)
1998
30
A new hot spot for mutations in the ret protooncogene causing familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2A. (9506724)
1998
31
Biological properties of Ret with cysteine mutations correlate with multiple endocrine neoplasia type 2A, familial medullary thyroid carcinoma, and Hirschsprung's disease phenotype. (9230192)
1997
32
Treatment of minute medullary thyroid carcinoma in multiple endocrine neoplasia 2A families first diagnosed by DNA analysis of RET proto-oncogene mutations: a case report. (9070340)
1997
33
Detection of RET mutations in multiple endocrine neoplasia type 2a and familial medullary thyroid carcinoma by denaturing gradient gel electrophoresis. (8829625)
1996
34
Presymptomatic DNA screening in families with multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma. (7491529)
1995
35
A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC. (7845675)
1995
36
Experience with a provocative test of calcitonin release as a prospective screening for preclinical medullary thyroid carcinoma in MEN type 2A family members. (1359042)
1992
37
Calcitonin and PDN-21 as tumour markers in MEN-2 family screening for medullary thyroid carcinoma. (1350454)
1992
38
Familial nonmultiple endocrine neoplasia medullary thyroid carcinoma: an evolving clinical entity. (1411944)
1992
39
Prognostic significance of nondiploid DNA determined by flow cytometry in sporadic and familial medullary thyroid carcinoma. (2247843)
1990
40
Familial medullary thyroid carcinoma without associated endocrinopathies: a distinct clinical entity. (3697657)
1986
41
Occurrence of calcitonin, somatostatin-like immunoreactivity, and carcinoembryonic antigen in two sisters suffering from familial thyroid medullary carcinoma. (2881797)
1986
42
Screening for familial medullary thyroid carcinoma: a review. (6747984)
1984
43
Calcitonin, somatostatin and ACTH immunoreactive cells in a case of familial bilateral thyroid medullary carcinoma. (6126268)
1982
44
Gastrin Responses to a test meal in patients with familial medullary thyroid carcinoma. (7061688)
1982
45
Thyroid venous catheterization in the early diagnosis of familial medullary thyroid carcinoma. (7125737)
1982
46
Familial medullary thyroid carcinoma and C cell hyperplasia. (7285384)
1981
47
Levels of histaminase and L-DOPA decarboxylase activity in the transition from C-cell hyperplasia to familial medullary thyroid carcinoma. (115572)
1979
48
Cellular immune responses in familial medullary thyroid carcinoma. (321956)
1977
49
Natural history of the familial medullary thyroid carcinoma-pheochromocytoma syndrome and the identification of preneoplastic stages by screening studies: a five-year report. (1224435)
1975
50
Studies in familial (medullary) thyroid carcinoma. (4347303)
1972

Genetic Variations for Familial Medullary Thyroid Carcinoma

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Familial Medullary Thyroid Carcinoma:

62 (show all 30)
id Symbol AA change Variation ID SNP ID
1RETp.Cys609TyrVAR_006306rs77939446
2RETp.Cys611TrpVAR_006308rs80069458
3RETp.Cys618ArgVAR_006311rs76262710
4RETp.Cys618PheVAR_006312
5RETp.Cys618SerVAR_006313rs79781594
6RETp.Cys618TyrVAR_006314
7RETp.Cys620GlyVAR_006315
8RETp.Cys620ArgVAR_006316
9RETp.Cys620SerVAR_006317
10RETp.Cys620PheVAR_006318rs77503355
11RETp.Cys630PheVAR_006320
12RETp.Cys634TyrVAR_006325
13RETp.Cys634ArgVAR_006326
14RETp.Cys634SerVAR_006327
15RETp.Cys634TrpVAR_006328
16RETp.Glu768AspVAR_006335rs78014899
17RETp.Val804LeuVAR_006336rs79658334
18RETp.Val804MetVAR_006337rs79658334
19RETp.Met918ThrVAR_006342rs74799832
20RETp.Thr946MetVAR_006345
21RETp.Cys611GlyVAR_009472
22RETp.Cys630SerVAR_009477
23RETp.Cys630TyrVAR_009478
24RETp.Leu790PheVAR_009482rs75030001
25RETp.Tyr791PheVAR_009483rs77724903
26RETp.Ser891AlaVAR_009486rs75234356
27RETp.Arg844LeuVAR_011582rs55947360
28RETp.Ala639GlyVAR_012743
29RETp.Ala641GlyVAR_012744
30RETp.Ser922PheVAR_012745

Expression for genes affiliated with Familial Medullary Thyroid Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Medullary Thyroid Carcinoma

Search GEO for disease gene expression data for Familial Medullary Thyroid Carcinoma.

Pathways for genes affiliated with Familial Medullary Thyroid Carcinoma

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 29KEGG, 52R&D Systems, 55SinoBiological, 59Tocris Bioscience, 49PharmGKB
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Pathways related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6MAPK3, NTRK1
2
Hide members
9.4NTRK1, STAT3
39.3FOS, MAPK3
4
Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
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9.3FOS, MAPK3
59.3MAPK3, FOS
69.3MAPK3, FOS
79.3MAPK3, FOS
89.3MAPK3, FOS
99.2SDHC, SDHB, SDHD
10
Hide members
9.2SDHC, SDHB, SDHD
11
Hide members
9.2SDHC, SDHB, SDHD
12
Hide members
9.2SDHD, SDHB, SDHC
139.2RET, MAPK3, NTRK1
149.1FOS, STAT3
15
Hide members
9.0STAT3, MAPK3
169.0MAPK3, STAT3
17
Hide members
9.0FOS, NTRK1, MAPK3
189.0RET, GDNF, MAPK3
198.8GDNF, MAPK3, FOS
208.7STAT3, NTRK1, MAPK3
21
Hide members
8.7STAT3, NTRK1, MAPK3
22
Hide members
8.6MAPK3, SDHD, SDHB, SDHC
238.5FOS, STAT3, MAPK3
24
Hide members
8.5FOS, STAT3, MAPK3
25
Hide members
8.5MAPK3, STAT3, FOS
26
Development Prolactin receptor signaling
Hide members
8.5MAPK3, STAT3, FOS
27
Development PDGF signaling via STATs and NF-kB
Hide members
8.5FOS, STAT3, MAPK3
28
Hide members
8.5FOS, STAT3, MAPK3
29
Hide members
8.5MAPK3, STAT3, FOS
308.5MAPK3, STAT3, FOS
318.5MAPK3, STAT3, FOS
32
Hide members
8.5MAPK3, STAT3, FOS
338.5FOS, STAT3, MAPK3
34
Hide members
8.5MAPK3, STAT3, FOS
35
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
8.5MAPK3, STAT3, FOS
36
Immune response IL-6 signaling pathway
Hide members
8.5FOS, STAT3, MAPK3
37
Hide members
8.5MAPK3, STAT3, FOS
388.5MAPK3, STAT3, FOS
398.5MAPK3, STAT3, FOS
40
Hide members
8.5FOS, STAT3, MAPK3
418.5MAPK3, STAT3, FOS
42
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
8.5FOS, STAT3, MAPK3
43
Mucin expression in CF via IL-6, IL-17 signaling pathways
Hide members
8.5FOS, STAT3, MAPK3
44
Hide members
8.5MAPK3, STAT3, FOS
45
Hide members
8.2MAPK3, NTRK1, STAT3, FOS
468.2FOS, STAT3, NTRK1, MAPK3
47
Hide members
8.2FOS, STAT3, NTRK1, MAPK3
487.9FOS, STAT3, NTRK1, MAPK3, RET
49
Hide members
7.7FOS, STAT3, NTRK1, MAPK3, GDNF
50
Hide members
7.7RET, GDNF, MAPK3, STAT3, FOS

Compounds for genes affiliated with Familial Medullary Thyroid Carcinoma

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1cipa4410.2RET, NTRK1
2glutamate4410.0GDNF, NTRK1
3mibg449.7CALCA, SDHD, SDHB
4UBIQUINONE-1119.7SDHC, SDHB, SDHD
52-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol119.6SDHD, SDHB, SDHC
6fumarate44 1110.6SDHC, SDHB, SDHD
7succinic acid28 11 2411.6SDHD, SDHB, SDHC
8iron-sulfur449.6SDHD, SDHB, SDHC
9ubiquinone449.6SDHC, SDHB, SDHD
10succinate449.3RET, SDHD, SDHB, SDHC
11capsaicin44 2810.2CALCA, FOS, NTRK1, GDNF
12anisomycin44 1110.2MAPK3, STAT3
13forskolin44 49 1111.1GDNF, MAPK3, CALCA
14phorbol449.0MAPK3, NTRK1, FOS
15vanadate449.0MAPK3, NTRK1, STAT3
16catecholamine449.0NTRK1, GDNF, RET, SDHD, SDHB
17norepinephrine44 11 2410.8CALCA, MAPK3, GDNF, SDHB
18ag 1478448.7FOS, STAT3, MAPK3
19losartan44 49 28 1111.7FOS, STAT3, MAPK3
20nmda44 289.6SDHB, GDNF, MAPK3, FOS
21gp 130448.6FOS, STAT3, MAPK3
22tamoxifen44 49 28 1111.5FOS, STAT3, NTRK1, MAPK3
23agar448.5FOS, STAT3, MAPK3, RET
24dopamine44 28 11 2411.5FOS, NTRK1, MAPK3, GDNF, SDHB
25sp 60012544 599.4MAPK3, STAT3, FOS
26phosphotyrosine448.3FOS, STAT3, NTRK1, MAPK3, RET
27oligonucleotide448.3RET, GDNF, NTRK1, STAT3, FOS
2812-o-tetradecanoylphorbol 13-acetate448.3RET, MAPK3, NTRK1, STAT3, FOS
29cyclic amp44 249.3CALCA, FOS, NTRK1, MAPK3, GDNF, RET
30iron44 249.3STAT3, GDNF, SDHD, SDHB, SDHC
31arachidonic acid44 28 11 2411.2FOS, STAT3, NTRK1, MAPK3
32oxygen44 249.1NTRK1, GDNF, SDHD, SDHB, SDHC
33threonine448.1FOS, STAT3, NTRK1, MAPK3, RET
34phosphoinositide448.1FOS, STAT3, NTRK1, MAPK3, GDNF
35testosterone44 59 11 2411.0CALCA, STAT3, NTRK1, MAPK3, RET, SDHB
36aspartate447.9STAT3, NTRK1, MAPK3, GDNF, RET, SDHB
37alanine447.8STAT3, NTRK1, MAPK3, GDNF, RET, SDHB
38pd 98,059447.8FOS, STAT3, NTRK1, MAPK3, GDNF, RET
39ly294002447.8FOS, STAT3, NTRK1, MAPK3, GDNF, RET
40wortmannin447.8FOS, STAT3, NTRK1, MAPK3, GDNF, RET
41genistein44 28 59 2 11 2412.8FOS, STAT3, NTRK1, MAPK3, GDNF, RET
42atp44 288.8STAT3, NTRK1, MAPK3, GDNF, RET, SDHB
43cysteine447.8STAT3, NTRK1, MAPK3, GDNF, RET, SDHB
44phosphatidylinositol447.8FOS, STAT3, NTRK1, MAPK3, GDNF, RET
45calcium44 49 11 2410.7CALCA, FOS, NTRK1, MAPK3, GDNF, RET
46h2o2447.6FOS, STAT3, NTRK1, MAPK3, GDNF, SDHB
47serine447.5FOS, STAT3, NTRK1, MAPK3, GDNF, RET
48retinoic acid44 248.4FOS, STAT3, NTRK1, MAPK3, GDNF, RET
49tyrosine447.3FOS, STAT3, NTRK1, MAPK3, GDNF, RET
50vegf446.6SDHC, CALCA, FOS, STAT3, NTRK1, MAPK3

GO Terms for genes affiliated with Familial Medullary Thyroid Carcinoma

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16Gene Ontology
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Cellular components related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:0057499.2SDHC, SDHB, SDHD

Biological processes related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1detection of temperature stimulus involved in sensory perception of painGO:05096510.1NTRK1, CALCA
2response to painGO:04826510.0CALCA, RET
3aerobic respirationGO:0090609.8SDHC, SDHB
4enteric nervous system developmentGO:0484849.8RET, GDNF
5sympathetic nervous system developmentGO:0484859.8GDNF, NTRK1
6agingGO:0075689.5CALCA, FOS, NTRK1
7activation of adenylate cyclase activityGO:0071909.5CALCA, NTRK1
8tricarboxylic acid cycleGO:0060999.5SDHC, SDHB, SDHD
9respiratory electron transport chainGO:0229049.5SDHC, SDHB, SDHD
10cellular metabolic processGO:0442379.5SDHC, SDHB, SDHD
11protein phosphorylationGO:0064689.2CALCA, NTRK1, MAPK3, RET
12cellular response to hormone stimulusGO:0328709.1FOS, STAT3
13JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.1STAT3, MAPK3
14phosphorylationGO:0163108.9MAPK3, STAT3
15positive regulation of transcription from RNA polymerase II promoterGO:0459448.0GDNF, MAPK3, STAT3, FOS

Molecular functions related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.9RET, NTRK1
2ubiquinone bindingGO:0480399.5SDHB, SDHD
3electron carrier activityGO:0090558.9SDHC, SDHB, SDHD

Products for genes affiliated with Familial Medullary Thyroid Carcinoma

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  • Antibodies
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Sources for Familial Medullary Thyroid Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet