MCID: FML010
MIFTS: 50

Familial Medullary Thyroid Carcinoma malady

Cancer, Genetic categories

Summaries for Familial Medullary Thyroid Carcinoma

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 The term multiple endocrine neoplasia (MEN) encompasses several distinct syndromes featuring tumors of... more...

MalaCards: Familial Medullary Thyroid Carcinoma, also known as thyroid carcinoma, familial medullary, is related to thyroid medullary carcinoma and multiple endocrine neoplasia. An important gene associated with Familial Medullary Thyroid Carcinoma is NTRK1 (neurotrophic tyrosine kinase, receptor, type 1), and among its related pathways are ARMS-mediated activation and TRKA activation by NGF. The compounds cipa and glutamate have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Description from OMIM:47 155240

Aliases & Classifications for Familial Medullary Thyroid Carcinoma

Sources:
8Disease Ontology, 10DISEASES, 20GeneTests, 22GTR, 45Novoseek, 61UMLS, 47OMIM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer, Genetic


Aliases & Descriptions:

familial medullary thyroid carcinoma 8 10
thyroid carcinoma, familial medullary 8 20 22 45 61
medullary thyroid carcinoma, familial 47


External Ids:

Disease Ontology8 DOID:0050547
OMIM47 155240

Related Diseases for Familial Medullary Thyroid Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Familial Medullary Thyroid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid medullary carcinoma31.8CALCA, NTRK1, GDNF, RET
2multiple endocrine neoplasia31.3SDHD, RET, GDNF, CALCA, SDHB, SDHC
3pheochromocytoma30.8RET, SDHD, SDHB
4papillary carcinoma30.5RET, NTRK1, CALCA
5hirschsprung's disease30.5NTRK1, GDNF, RET
6phaeochromocytoma30.5SDHB, SDHD, RET, CALCA, SDHC
7parathyroid carcinoma30.3RET
8adenoma30.3CALCA, NTRK1, MAPK3, GDNF, RET
9n syndrome10.5
10amyloidosis10.5
11sipple syndrome10.4
12familial papillary thyroid carcinoma10.4
13ntrk1-related familial medullary thyroid carcinoma10.4
14lichen amyloidosis10.4
15adrenal medulla carcinoma10.2
16primary cutaneous amyloidosis10.2
17adrenal carcinoma10.2
18thyroid adenoma10.2
19sporadic pheochromocytoma10.2
20primary localized amyloidosis10.2
21thyroiditis10.0CALCA
22neuroendocrine tumor10.0CALCA
23insulinoma10.0CALCA
24leprosy10.0SDHD
25hypertension10.0CALCA
26sarcoma10.0NTRK1
27neuroblastoma10.0NTRK1
28primary hyperoxaluria10.0FOS
29rhabdomyosarcoma10.0NTRK1
30central hypoventilation syndrome10.0GDNF
31asthma10.0FOS
32thymoma10.0NTRK1
33paragangliomas 110.0RET, SDHB
34nodular goiter10.0RET, CALCA
35chagas disease10.0NTRK1
36pituitary adenoma10.0GDNF, RET
37obesity10.0STAT3
38thyroid cancer10.0CALCA, RET
39follicular thyroid carcinoma10.0CALCA, RET
40neurofibromatosis10.0SDHB, SDHD
41primary hyperparathyroidism10.0RET, CALCA
42parkinson's disease10.0GDNF, FOS
43glomus tumor10.0SDHD, SDHB
44amyotrophic lateral sclerosis10.0GDNF, NTRK1
45skin cancer10.0FOS
46carcinoid syndrome10.0SDHD, RET, CALCA
47familial colorectal cancer10.0RET, SDHD, SDHB
48osteoarthritis10.0NTRK1, CALCA
49toxic encephalopathy10.0GDNF, FOS
50intestinal obstruction10.0RET, GDNF

Graphical network of the top 20 diseases related to Familial Medullary Thyroid Carcinoma:



Diseases related to familial medullary thyroid carcinoma

Clinical Features for Familial Medullary Thyroid Carcinoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

155240

Clinical synopsis from OMIM:

155240

Drugs & Therapeutics for Familial Medullary Thyroid Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Familial Medullary Thyroid Carcinoma

Drug clinical trials:

Search ClinicalTrials for Familial Medullary Thyroid Carcinoma

Search NIH Clinical Center for Familial Medullary Thyroid Carcinoma

Search CenterWatch for Familial Medullary Thyroid Carcinoma

Genetic Tests for Familial Medullary Thyroid Carcinoma

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Familial Medullary Thyroid Carcinoma:

id Genetic test Affiliating Genes
1 Familial Medullary Thyroid Carcinoma20 22

Anatomical Context for Familial Medullary Thyroid Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Familial Medullary Thyroid Carcinoma:

33
Thyroid

Animal Models for Familial Medullary Thyroid Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Familial Medullary Thyroid Carcinoma

Sources:
51PubMed
See all sources

Articles related to Familial Medullary Thyroid Carcinoma:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma: an update. (23744408)
2013
2
Familial medullary thyroid carcinoma associated with cutaneous lichen amyloidosis. (19445625)
2009
3
Sporadic and familial medullary thyroid carcinoma: state of the art. (19836492)
2009
4
Familial non-medullary thyroid carcinoma: an update. (18931957)
2008
5
Multiple endocrine neoplasia type 2A in two families with the familial medullary thyroid carcinoma associated G533C mutation of the RET proto-oncogene. (18805915)
2008
6
A rare RET gene exon 8 mutation is found in two Greek kindreds with familial medullary thyroid carcinoma: implications for screening. (16649977)
2006
7
Association of mitochondrial DNA transversion mutations with familial medullary thyroid carcinoma/multiple endocrine neoplasia type 2 syndrome. (16205644)
2006
8
Exon 5 of the RET proto-oncogene: a newly detected risk exon for familial medullary thyroid carcinoma, a novel germ-line mutation Gly321Arg. (16419493)
2005
9
No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinoma. (16322339)
2005
10
RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor. (15753368)
2005
11
RET oncogene mutations in 75 cases of familial medullary thyroid carcinoma in Japan. (15271413)
2004
12
The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma. (15277225)
2004
13
Clinical manifestations of familial medullary thyroid carcinoma. (15271414)
2004
14
A novel germ-line point mutation in RET exon 8 (Gly(533)Cys) in a large kindred with familial medullary thyroid carcinoma. (14602786)
2003
15
Study of RET protooncogene in multiple endocrine neoplasm 2A and in familial medullary thyroid carcinoma. Clinical pathological findings in asymptomatic carriers]. (12673960)
2003
16
Various penetrance of familial medullary thyroid carcinoma in patients with RET protooncogene codon 790/791 germline mutations. (12409662)
2002
17
Familial medullary thyroid carcinoma: clinical variability and low aggressiveness associated with RET mutation at codon 804. (11932300)
2002
18
Familial medullary thyroid carcinoma (FMTC). Study of one family (treatment criteria). (11289752)
2001
19
Molecular genetic diagnostic program of multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma syndromes in Hungary. (11524247)
2001
20
Diagnosis and therapy of sporadic and familial medullary thyroid carcinoma. (11260860)
2001
21
From gene to disease; from the RET gene to multiple endocrine neoplasia types 2A and 2B, sporadic and familial medullary thyroid carcinoma, Hirschsprung disease and papillary thyroid carcinoma]. (11757244)
2001
22
Is thyroidectomy necessary in RET mutations carriers of the familial medullary thyroid carcinoma syndrome? (10951350)
2000
23
Variable expressivity of familial medullary thyroid carcinoma (FMTC) due to a RET V804M (GTG-->ATG) mutation. (10876191)
2000
24
Prognosis of a family with familial medullary thyroid carcinoma. (10464711)
1999
25
A novel 9-base pair duplication in RET exon 8 in familial medullary thyroid carcinoma. (10323403)
1999
26
A codon 891 exon 15 RET proto-oncogene mutation in familial medullary thyroid carcinoma: a detection strategy. (10024437)
1999
27
A GTG to ATG novel point mutation at codon 804 in exon 14 of the RET proto-oncogene in two families affected by familial medullary thyroid carcinoma. (9452077)
1998
28
Germ line mutation analysis in families with multiple endocrine neoplasia type 2A or familial medullary thyroid carcinoma. (9820617)
1998
29
Does the syndrome of familial medullary thyroid carcinoma describe a distinct clinical entity? (9893644)
1998
30
Results of the calcitonin stimulation test in normal volunteers compared with genetically unaffected members of MEN 2A and familial medullary thyroid carcinoma families. (9436479)
1997
31
Prevalence and parental origin of de novo RET mutations in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma. Le Groupe d'Etude des Tumeurs a Calcitonine. (8981969)
1997
32
Familial medullary thyroid carcinoma: not a distinct entity? Genotype-phenotype correlation in a large family. (9003111)
1996
33
Immune response against medullary thyroid carcinoma (MTC) induced by parental and/or interleukin-2-secreting MTC cells in a rat model of human familial medullary thyroid carcinoma. (8954146)
1996
34
Detection of RET mutations in multiple endocrine neoplasia type 2a and familial medullary thyroid carcinoma by denaturing gradient gel electrophoresis. (8829625)
1996
35
Presymptomatic DNA screening in families with multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma. (7491529)
1995
36
A rapid screening method for the detection of mutations in the RET proto-oncogene in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma families. (7835899)
1994
37
Mapping the inherited defects associated with multiple endocrine neoplasia type 2A, multiple endocrine neoplasia type 2B, and familial medullary thyroid carcinoma to chromosome 10 by linkage analysis. (7913024)
1994
38
Familial nonmultiple endocrine neoplasia medullary thyroid carcinoma: an evolving clinical entity. (1411944)
1992
39
Familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2B map to the same region of chromosome 10 as multiple endocrine neoplasia type 2A. (1672289)
1991
40
Incidence of sporadic and familial medullary thyroid carcinoma in Sweden 1959 through 1981. A nationwide study in 126 patients. Swedish MCT Study Group. (2310607)
1990
41
Prognostic significance of nondiploid DNA determined by flow cytometry in sporadic and familial medullary thyroid carcinoma. (2247843)
1990
42
Familial medullary thyroid carcinoma without associated endocrinopathies: a distinct clinical entity. (3697657)
1986
43
Occurrence of calcitonin, somatostatin-like immunoreactivity, and carcinoembryonic antigen in two sisters suffering from familial thyroid medullary carcinoma. (2881797)
1986
44
Diagnostic usefulness of the calcitonin secretion induced with pentagastrin in the familial medullary thyroid carcinoma. (2870690)
1985
45
Calcitonin, somatostatin and ACTH immunoreactive cells in a case of familial bilateral thyroid medullary carcinoma. (6126268)
1982
46
Thyroid venous catheterization in the early diagnosis of familial medullary thyroid carcinoma. (7125737)
1982
47
Familial medullary thyroid carcinoma and C cell hyperplasia. (7285384)
1981
48
Natural history of familial medullary thyroid carcinoma: effect of a program for early diagnosis. (692625)
1978
49
Management of familial medullary thyroid carcinoma and phaeochromocytoma. (1166060)
1975
50
On the occurrence of monoamines and related substances in familial medullary thyroid carcinoma with phaeochromocytoma. (5700277)
1968

Genetic Variations for Familial Medullary Thyroid Carcinoma

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Familial Medullary Thyroid Carcinoma:

63 (show all 30)
id Symbol AA change Variation SNP ID
1RETp.Cys609TyrVAR_006306rs77939446
2RETp.Cys611TrpVAR_006308rs80069458
3RETp.Cys618ArgVAR_006311rs76262710
4RETp.Cys618PheVAR_006312
5RETp.Cys618SerVAR_006313rs79781594
6RETp.Cys618TyrVAR_006314
7RETp.Cys620GlyVAR_006315
8RETp.Cys620ArgVAR_006316
9RETp.Cys620SerVAR_006317
10RETp.Cys620PheVAR_006318rs77503355
11RETp.Cys630PheVAR_006320
12RETp.Cys634TyrVAR_006325
13RETp.Cys634ArgVAR_006326
14RETp.Cys634SerVAR_006327
15RETp.Cys634TrpVAR_006328
16RETp.Glu768AspVAR_006335rs78014899
17RETp.Val804LeuVAR_006336rs79658334
18RETp.Val804MetVAR_006337rs79658334
19RETp.Met918ThrVAR_006342rs74799832
20RETp.Thr946MetVAR_006345
21RETp.Cys611GlyVAR_009472
22RETp.Cys630SerVAR_009477
23RETp.Cys630TyrVAR_009478
24RETp.Leu790PheVAR_009482rs75030001
25RETp.Tyr791PheVAR_009483rs77724903
26RETp.Ser891AlaVAR_009486rs75234356
27RETp.Arg844LeuVAR_011582rs55947360
28RETp.Ala639GlyVAR_012743
29RETp.Ala641GlyVAR_012744
30RETp.Ser922PheVAR_012745

Expression for genes affiliated with Familial Medullary Thyroid Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Familial Medullary Thyroid Carcinoma

Search GEO for disease gene expression data for Familial Medullary Thyroid Carcinoma.

Pathways for genes affiliated with Familial Medullary Thyroid Carcinoma

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 30KEGG, 53R&D Systems, 56SinoBiological, 60Tocris Bioscience, 50PharmGKB
See all sources

Pathways related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6MAPK3, NTRK1
2
Hide members
9.4NTRK1, STAT3
39.3FOS, MAPK3
4
Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
Hide members
9.3FOS, MAPK3
59.3MAPK3, FOS
69.3MAPK3, FOS
79.3MAPK3, FOS
89.3MAPK3, FOS
99.2SDHC, SDHB, SDHD
10
Hide members
9.2SDHC, SDHB, SDHD
11
Hide members
9.2SDHC, SDHB, SDHD
12
Hide members
9.2SDHD, SDHB, SDHC
139.2RET, MAPK3, NTRK1
149.1FOS, STAT3
15
Hide members
9.0STAT3, MAPK3
169.0MAPK3, STAT3
17
Hide members
9.0FOS, NTRK1, MAPK3
189.0RET, GDNF, MAPK3
198.8GDNF, MAPK3, FOS
208.7STAT3, NTRK1, MAPK3
21
Hide members
8.7STAT3, NTRK1, MAPK3
22
Hide members
8.6MAPK3, SDHD, SDHB, SDHC
238.5FOS, STAT3, MAPK3
24
Hide members
8.5FOS, STAT3, MAPK3
25
Hide members
8.5MAPK3, STAT3, FOS
26
Development Prolactin receptor signaling
Hide members
8.5MAPK3, STAT3, FOS
27
Development PDGF signaling via STATs and NF-kB
Hide members
8.5FOS, STAT3, MAPK3
28
Hide members
8.5FOS, STAT3, MAPK3
29
Hide members
8.5MAPK3, STAT3, FOS
308.5MAPK3, STAT3, FOS
318.5MAPK3, STAT3, FOS
32
Hide members
8.5MAPK3, STAT3, FOS
338.5FOS, STAT3, MAPK3
34
Hide members
8.5MAPK3, STAT3, FOS
35
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
8.5MAPK3, STAT3, FOS
36
Immune response IL-6 signaling pathway
Hide members
8.5FOS, STAT3, MAPK3
37
Hide members
8.5MAPK3, STAT3, FOS
388.5MAPK3, STAT3, FOS
398.5MAPK3, STAT3, FOS
40
Hide members
8.5FOS, STAT3, MAPK3
418.5MAPK3, STAT3, FOS
42
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
8.5FOS, STAT3, MAPK3
43
Mucin expression in CF via IL-6, IL-17 signaling pathways
Hide members
8.5FOS, STAT3, MAPK3
44
Hide members
8.5MAPK3, STAT3, FOS
45
Hide members
8.2MAPK3, NTRK1, STAT3, FOS
468.2FOS, STAT3, NTRK1, MAPK3
47
Hide members
8.2FOS, STAT3, NTRK1, MAPK3
487.9FOS, STAT3, NTRK1, MAPK3, RET
49
Hide members
7.7FOS, STAT3, NTRK1, MAPK3, GDNF
50
Hide members
7.7RET, GDNF, MAPK3, STAT3, FOS

Compounds for genes affiliated with Familial Medullary Thyroid Carcinoma

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1cipa4510.2RET, NTRK1
2glutamate4510.0GDNF, NTRK1
3mibg459.7CALCA, SDHD, SDHB
4UBIQUINONE-1119.7SDHC, SDHB, SDHD
52-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol119.6SDHD, SDHB, SDHC
6fumarate45 1110.6SDHC, SDHB, SDHD
7succinic acid29 11 2411.6SDHD, SDHB, SDHC
8iron-sulfur459.6SDHD, SDHB, SDHC
9ubiquinone459.6SDHC, SDHB, SDHD
10succinate459.3RET, SDHD, SDHB, SDHC
11capsaicin45 2910.2CALCA, FOS, NTRK1, GDNF
12anisomycin45 1110.2MAPK3, STAT3
13forskolin45 50 1111.1GDNF, MAPK3, CALCA
14phorbol459.0MAPK3, NTRK1, FOS
15vanadate459.0MAPK3, NTRK1, STAT3
16catecholamine459.0NTRK1, GDNF, RET, SDHD, SDHB
17norepinephrine45 11 2410.8CALCA, MAPK3, GDNF, SDHB
18ag 1478458.7FOS, STAT3, MAPK3
19losartan45 50 29 1111.7FOS, STAT3, MAPK3
20nmda45 299.6SDHB, GDNF, MAPK3, FOS
21gp 130458.6FOS, STAT3, MAPK3
22tamoxifen45 50 29 1111.5FOS, STAT3, NTRK1, MAPK3
23agar458.5FOS, STAT3, MAPK3, RET
24dopamine45 29 11 2411.5FOS, NTRK1, MAPK3, GDNF, SDHB
25sp 60012545 609.4MAPK3, STAT3, FOS
26phosphotyrosine458.3FOS, STAT3, NTRK1, MAPK3, RET
27oligonucleotide458.3RET, GDNF, NTRK1, STAT3, FOS
2812-o-tetradecanoylphorbol 13-acetate458.3RET, MAPK3, NTRK1, STAT3, FOS
29cyclic amp45 249.3CALCA, FOS, NTRK1, MAPK3, GDNF, RET
30iron45 249.3STAT3, GDNF, SDHD, SDHB, SDHC
31arachidonic acid45 29 11 2411.2FOS, STAT3, NTRK1, MAPK3
32oxygen45 249.1NTRK1, GDNF, SDHD, SDHB, SDHC
33threonine458.1FOS, STAT3, NTRK1, MAPK3, RET
34phosphoinositide458.1FOS, STAT3, NTRK1, MAPK3, GDNF
35testosterone45 60 11 2411.0CALCA, STAT3, NTRK1, MAPK3, RET, SDHB
36aspartate457.9STAT3, NTRK1, MAPK3, GDNF, RET, SDHB
37alanine457.8STAT3, NTRK1, MAPK3, GDNF, RET, SDHB
38pd 98,059457.8FOS, STAT3, NTRK1, MAPK3, GDNF, RET
39ly294002457.8FOS, STAT3, NTRK1, MAPK3, GDNF, RET
40wortmannin457.8FOS, STAT3, NTRK1, MAPK3, GDNF, RET
41genistein45 29 60 2 11 2412.8FOS, STAT3, NTRK1, MAPK3, GDNF, RET
42atp45 298.8STAT3, NTRK1, MAPK3, GDNF, RET, SDHB
43cysteine457.8STAT3, NTRK1, MAPK3, GDNF, RET, SDHB
44phosphatidylinositol457.8FOS, STAT3, NTRK1, MAPK3, GDNF, RET
45calcium45 50 11 2410.7CALCA, FOS, NTRK1, MAPK3, GDNF, RET
46h2o2457.6FOS, STAT3, NTRK1, MAPK3, GDNF, SDHB
47serine457.5FOS, STAT3, NTRK1, MAPK3, GDNF, RET
48retinoic acid45 248.4FOS, STAT3, NTRK1, MAPK3, GDNF, RET
49tyrosine457.3FOS, STAT3, NTRK1, MAPK3, GDNF, RET
50vegf456.6SDHC, CALCA, FOS, STAT3, NTRK1, MAPK3

GO Terms for genes affiliated with Familial Medullary Thyroid Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:0057499.2SDHC, SDHB, SDHD

Biological processes related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1detection of temperature stimulus involved in sensory perception of painGO:05096510.1NTRK1, CALCA
2response to painGO:04826510.0CALCA, RET
3aerobic respirationGO:0090609.8SDHC, SDHB
4enteric nervous system developmentGO:0484849.8RET, GDNF
5sympathetic nervous system developmentGO:0484859.8GDNF, NTRK1
6agingGO:0075689.5CALCA, FOS, NTRK1
7activation of adenylate cyclase activityGO:0071909.5CALCA, NTRK1
8tricarboxylic acid cycleGO:0060999.5SDHC, SDHB, SDHD
9respiratory electron transport chainGO:0229049.5SDHC, SDHB, SDHD
10cellular metabolic processGO:0442379.5SDHC, SDHB, SDHD
11protein phosphorylationGO:0064689.2CALCA, NTRK1, MAPK3, RET
12cellular response to hormone stimulusGO:0328709.1FOS, STAT3
13JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.1STAT3, MAPK3
14phosphorylationGO:0163108.9MAPK3, STAT3
15positive regulation of transcription from RNA polymerase II promoterGO:0459448.0GDNF, MAPK3, STAT3, FOS

Molecular functions related to Familial Medullary Thyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.9RET, NTRK1
2ubiquinone bindingGO:0480399.5SDHB, SDHD
3electron carrier activityGO:0090558.9SDHC, SDHB, SDHD

Products for genes affiliated with Familial Medullary Thyroid Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Familial Medullary Thyroid Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet