Familial Osteochondritis Dissecans malady

Genetics Home Reference: Familial osteochondritis dissecans is a condition that affects the joints and is associated with abnormal cartilage. Cartilage is a tough but flexible tissue that covers the ends of the bones at joints and is also part of the developing skeleton. A characteristic feature of familial osteochondritis dissecans is areas of bone damage (lesions) caused by detachment of cartilage and a piece of the underlying bone from the end of the bone at a joint. People with this condition develop multiple lesions that affect several joints, primarily the knees, elbows, hips, and ankles. The lesions cause stiffness, pain, and swelling in the joint. Often, the affected joint feels like it catches or locks during movement. Other characteristic features of familial osteochondritis dissecans include short stature and development of a joint disorder called osteoarthritis at an early age. Osteoarthritis is characterized by the breakdown of joint cartilage and the underlying bone. It causes pain and stiffness and restricts the movement of joints.¹⁷

MalaCards: Familial Osteochondritis Dissecans, also known as osteochondritis dissecans, short stature, and early-onset osteoarthritis, is related to osteochondritis dissecans and epiphyseal dysplasia. Affiliated tissues include skin.

MedlinePlus: Cartilage is the tough but flexible tissue that covers the ends of your bones at a joint. it also gives shape and support to other parts of your body, such as your ears, nose and windpipe. healthy cartilage helps you move by allowing your bones to glide over each other. it also protects bones by preventing them from rubbing against each other. injured, inflamed or damaged cartilage can cause symptoms such as pain and limited movement. it can also lead to joint damage and deformity. causes of cartilage problems include tears and injuries, such as sports injuries genetic factors other disorders, such as some types of arthritis osteoarthritis results from breakdown of cartilage. nih: national institute of arthritis and musculoskeletal and skin diseases²³

OMIM: 165800

familial osteochondritis dissecans 17 osteochondritis dissecans, short stature, and early-onset osteoarthritis 17 33 cartilage disorders 17 23 osteochondritis dissecans 17

cartilage diseases 32 focd 17 ocd 17 od 17

Diseases related to familial osteochondritis dissecans by text searches and GeneDecks gene sharing:

(show top 50)    (show all 55)

id	Related Disease	Score	Top Affiliating Genes
1	osteochondritis dissecans	9.2
2	epiphyseal dysplasia	7.4
3	osteonecrosis	7.4
4	pandas	7.2
5	obsessive-compulsive disorder 1	6.9
6	breast cancer	6.8
7	asthma	6.4
8	cerebritis	6.4
9	anxiety-related personality traits	6.3
10	osteochondrodysplasia	6.3
11	feingold syndrome	5.9
12	feingold syndrome 1	5.9
13	retinitis	5.9
14	squamous cell carcinoma	5.9
15	wilms tumor	5.9
16	esophagitis	5.9
17	tietze's syndrome	5.4
18	adhd	5.4
19	basal ganglia disease	5.4
20	succinic semialdehyde dehydrogenase deficiency	5.4
21	stereotypic movement disorder	5.4
22	trichotillomania	5.4
23	tourette syndrome	5.4
24	velocardiofacial syndrome	5.4
25	osteolysis	5.4
26	cartilage disease	5.4
27	joint disorders	5.4
28	laryngeal cartilage cancer	5.4
29	epithelial ovarian cancer	5.0
30	ovarian cancer	5.0
31	esophageal carcinoma	5.0
32	peritonitis	5.0
33	hepatitis b	5.0
34	retinitis pigmentosa	5.0
35	spastic paraparesis	5.0
36	hepatocellular cancer	5.0
37	herpes simplex	5.0
38	severe combined immunodeficiency	5.0
39	acute myeloid leukemia	5.0
40	thrombosis	5.0
41	alzheimer's disease	5.0
42	tropical spastic paraparesis	5.0
43	astrocytoma	5.0
44	testicular cancer	5.0
45	blindness	5.0
46	leukemia/lymphoma	5.0
47	ulcerative colitis	5.0
48	bipolar affective disorder	5.0
49	lung cancer	5.0
50	vitiligo	5.0

Clinical features from OMIM: 165800

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to familial osteochondritis dissecans:

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