MCID: FML143
MIFTS: 27

Familial Papillary Thyroid Carcinoma

Categories: Genetic diseases, Cancer diseases

Aliases & Classifications for Familial Papillary Thyroid Carcinoma

MalaCards integrated aliases for Familial Papillary Thyroid Carcinoma:

Name: Familial Papillary Thyroid Carcinoma 24
Familial Nonmedullary Thyroid Cancer 24 69
Familial Papillary Thyroid Cancer 24

Classifications:



Summaries for Familial Papillary Thyroid Carcinoma

MalaCards based summary : Familial Papillary Thyroid Carcinoma, also known as familial nonmedullary thyroid cancer, is related to thyroid cancer, nonmedullary, 1 and thyroid carcinoma, papillary, with papillary renal neoplasia. An important gene associated with Familial Papillary Thyroid Carcinoma is HABP2 (Hyaluronan Binding Protein 2), and among its related pathways/superpathways are Neuroscience and Tyrosine Kinases / Adaptors. The drugs Rosiglitazone and Trametinib have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Related Diseases for Familial Papillary Thyroid Carcinoma

Diseases related to Familial Papillary Thyroid Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
id Related Disease Score Top Affiliating Genes
1 thyroid cancer, nonmedullary, 1 11.3
2 thyroid carcinoma, papillary, with papillary renal neoplasia 11.0
3 thyroid cancer 10.4
4 thyroiditis 10.3
5 adenomatous polyposis coli 9.7
6 familial adenomatous polyposis 9.7
7 cavernous hemangioma 9.6 NTRK1 RET
8 chorea, hereditary benign 9.5 NTRK1 RET
9 pheochromocytoma 9.5 NTRK1 RET
10 non-distal trisomy 10q 9.4 NTRK1 RET
11 medullary thyroid carcinoma, familial 9.2 NTRK1 RET
12 familial schizencephaly, shh-related 9.0 HABP2 NTRK1 RET
13 peritoneal mesothelioma 9.0 HABP2 NTRK1 RET

Graphical network of the top 20 diseases related to Familial Papillary Thyroid Carcinoma:



Diseases related to Familial Papillary Thyroid Carcinoma

Symptoms & Phenotypes for Familial Papillary Thyroid Carcinoma

GenomeRNAi Phenotypes related to Familial Papillary Thyroid Carcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 10.16 NTRK1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 10.16 RET HABP2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 10.16 NTRK1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 10.16 HABP2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 10.16 RET
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 10.16 RET
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.16 NTRK1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 10.16 RET NTRK1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-64 10.16 HABP2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 10.16 HABP2
11 Decreased viability GR00221-A-1 9.7 RET
12 Decreased viability GR00221-A-2 9.7 RET
13 Decreased viability GR00221-A-3 9.7 NTRK1
14 Decreased viability GR00221-A-4 9.7 RET
15 Decreased viability GR00231-A 9.7 RET
16 Decreased viability GR00301-A 9.7 RET NTRK1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.44 RET
18 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.44 RET
19 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.44 NTRK1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.44 RET
21 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.44 RET
22 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.44 RET
23 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.44 NTRK1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.44 NTRK1 RET
25 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.44 NTRK1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.44 RET
27 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.44 RET NTRK1
28 Increased cell viability after pRB stimulation GR00230-A-1 8.96 RET NTRK1

Drugs & Therapeutics for Familial Papillary Thyroid Carcinoma

Drugs for Familial Papillary Thyroid Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
2
Trametinib Approved Phase 2 871700-17-3 11707110
3
Maleic acid Experimental Phase 2 110-16-7 444266
4
Iodine Investigational Phase 2 7553-56-2 807
5 Hypoglycemic Agents Phase 2
6 Anti-Infective Agents Phase 2
7 Anti-Infective Agents, Local Phase 2
8 cadexomer iodine Phase 2
9 Micronutrients Phase 2
10 Protein Kinase Inhibitors Phase 2
11 Trace Elements Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Rosiglitazone in Treating Patients With Locoregionally Extensive or Metastatic Thyroid Cancer Unknown status NCT00098852 Phase 2 rosiglitazone maleate
2 Trametinib in Increasing Tumoral Iodine Incorporation in Patients With Recurrent or Metastatic Thyroid Cancer Recruiting NCT02152995 Phase 2 Trametinib
3 Treatment Decision-Making Among Patients Diagnosed With Papillary Microcarcinoma and Their Significant Others Completed NCT01392222
4 A Gene Hunting Study for Familial Papillary Thyroid Cancer Recruiting NCT02776969

Search NIH Clinical Center for Familial Papillary Thyroid Carcinoma

Genetic Tests for Familial Papillary Thyroid Carcinoma

Genetic tests related to Familial Papillary Thyroid Carcinoma:

id Genetic test Affiliating Genes
1 Familial Papillary Thyroid Carcinoma 24

Anatomical Context for Familial Papillary Thyroid Carcinoma

MalaCards organs/tissues related to Familial Papillary Thyroid Carcinoma:

39
Thyroid

Publications for Familial Papillary Thyroid Carcinoma

Articles related to Familial Papillary Thyroid Carcinoma:

(show all 13)
id Title Authors Year
1
Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of "thyroid-checked" controls. ( 28089742 )
2017
2
Letter regarding the article: "Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of "thyroid-checked" controls" by Kern etA al. ( 28779995 )
2017
3
Variants in microRNA genes in familial papillary thyroid carcinoma. ( 28031538 )
2016
4
Familial Papillary Thyroid Carcinoma (FPTC): a Retrospective Analysis in a Sample of the Bulgarian Population for a 10-Year Period. ( 27771834 )
2016
5
Clinicopathological features and prognosis of familial papillary thyroid carcinoma - a large-scale, matched, case-control study. ( 26191611 )
2015
6
Familial papillary thyroid carcinoma: a retrospective analysis. ( 22131992 )
2011
7
Biological behavior and prognosis of familial papillary thyroid carcinoma. ( 19081481 )
2009
8
A Greek family with a follicular variant of familial papillary thyroid carcinoma: TCO, MNG1, fPTC/PRN, and NMTC1 excluded as susceptibility loci. ( 16405407 )
2005
9
Familial papillary thyroid carcinoma. ( 16209057 )
2004
10
RET rearrangements in familial papillary thyroid carcinomas. ( 11463498 )
2001
11
Familial papillary thyroid carcinoma: genetics, criteria for diagnosis, clinical features, and surgical treatment. ( 11038215 )
2000
12
At least three genes account for familial papillary thyroid carcinoma: TCO and MNG1 excluded as susceptibility loci from a large Tasmanian family. ( 10427154 )
1999
13
Familial papillary thyroid carcinoma is genetically distinct from familial adenomatous polyposis coli. ( 10211600 )
1999

Variations for Familial Papillary Thyroid Carcinoma

Expression for Familial Papillary Thyroid Carcinoma

Search GEO for disease gene expression data for Familial Papillary Thyroid Carcinoma.

Pathways for Familial Papillary Thyroid Carcinoma

Pathways related to Familial Papillary Thyroid Carcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.67 NTRK1 RET
2 11.11 NTRK1 RET
3 10.44 NTRK1 RET

GO Terms for Familial Papillary Thyroid Carcinoma

Cellular components related to Familial Papillary Thyroid Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.32 NTRK1 RET
2 neuronal cell body GO:0043025 9.26 NTRK1 RET
3 axon GO:0030424 9.16 NTRK1 RET
4 early endosome GO:0005769 8.96 NTRK1 RET
5 receptor complex GO:0043235 8.62 NTRK1 RET

Biological processes related to Familial Papillary Thyroid Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.37 NTRK1 RET
2 axon guidance GO:0007411 9.32 NTRK1 RET
3 peptidyl-tyrosine phosphorylation GO:0018108 9.26 NTRK1 RET
4 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.16 NTRK1 RET
5 positive regulation of neuron projection development GO:0010976 8.96 NTRK1 RET
6 innervation GO:0060384 8.62 NTRK1 RET

Molecular functions related to Familial Papillary Thyroid Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 8.96 NTRK1 RET
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 NTRK1 RET

Sources for Familial Papillary Thyroid Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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