MCID: FML085
MIFTS: 40

Familial Prostate Cancer malady

Cancer, Genetic categories

Summaries for Familial Prostate Cancer

Sources:
47OMIM, 33MalaCards
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MalaCards: Familial Prostate Cancer, also known as prostate cancer, familial, is related to prostate cancer, progression and metastasis of and prostate cancer, hereditary, 12. An important gene associated with Familial Prostate Cancer is MSR1 (macrophage scavenger receptor 1), and among its related pathways are Valproic Acid Pathway, Pharmacokinetics and Estrogen metabolism. The compounds 20alpha-hydroxycholesterol and deoxycorticosterone have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and prostate.

Description from OMIM:47 176807

Aliases & Classifications for Familial Prostate Cancer

Sources:
43NIH Rare Diseases, 47OMIM, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer, Genetic


Aliases & Descriptions:

familial prostate cancer 43
prostate cancer, familial 43 47 61
prostate cancer, hereditary 43 47
malignant neoplasm of prostate 61
hereditary prostate cancer 43


Related Diseases for Familial Prostate Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the prostate cancer family:

familial prostate cancer prostate cancer 1
prostate cancer 4 prostate cancer 3

Diseases related to Familial Prostate Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1prostate cancer, progression and metastasis of10.3
2prostate cancer, hereditary, 1210.3
3prostate cancer, hereditary, 510.3
4prostate cancer, hereditary, 1010.3
5prostate cancer, hereditary, 1310.3
6prostate cancer, hereditary, 1410.3
7prostate cancer, hereditary, 710.3
8prostate cancer, hereditary, 910.3
9prostate cancer, hereditary, 1510.3
10prostate cancer, hereditary, x-linked 210.3
11prostate cancer, hereditary, x-linked 110.3
12familial breast cancer10.2
13prostate cancer 110.2
14prostate cancer, somatic10.2
15prostate cancer 410.2
16prostate cancer, hereditary, 210.1
17prostate cancer, hereditary, 1110.1
18prostate cancer 310.1
19bilateral breast cancer10.1
20adrenocortical carcinoma10.0HSD3B1
21breast-ovarian cancer, familial, 210.0HSD17B2
22cushing's syndrome10.0HSD3B1
23myeloid leukemia10.0AKR1C3
24hepatitis c10.0AMACR, RNASEL
25hepatitis10.0GSTT1, AMACR
26obesity10.0AKR1C3, CYP11A1
27penis agenesis10.0CYP17A1, SRD5A2
28hypospadias10.0SRD5A2, CYP17A1, HSD3B2, HSD3B1
29pseudohermaphroditism10.0SRD5A2, HSD3B1, HSD3B2, CYP17A1
30congenital adrenal hyperplasia10.0CYP11A1, HSD3B1, HSD3B2, CYP17A1
31leydig cell tumor10.0HSD3B1, CYP11A1, CYP17A1
32infertility10.0CYP11A1, GSTT1
33choriocarcinoma10.0CYP11A1
34polycystic ovary syndrome10.0HSD3B2, AKR1C3, CYP17A1, CYP11A1, HSD3B1
35addison's disease10.0HSD3B2, CYP17A1, CYP11A1
36hyperandrogenism10.0HSD3B2, AKR1C3, HSD3B1, CYP17A1, CYP11A1
37autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.0CYP11A1, CYP17A1
38adenoma10.0CYP11A1, CYP17A1, GSTT1, AMACR
39endometriosis10.0HSD17B2, CYP17A1, CYP11A1, GSTT1, HSD17B1
40conn's syndrome10.0CYP11A1, CYP17A1
41tuberculosis10.0AMACR, CYP11A1
42leiomyoma10.0CYP17A1
43adenocarcinoma10.0AKR1C3, NKX3-1, AMACR, GSTT1, CHEK2
44leukemia10.0GSTT1, RNASEL, CHEK2
45colorectal cancer10.0AMACR, CHEK2, CYP17A1, GSTT1, SULT1A1
46prostate cancer10.0AMACR, CHEK2, MSR1, CYP17A1, GSTT1, SRD5A2
47ovarian cancer10.0MSR1, CYP17A1, GSTT1, AMACR, SRD5A2, CHEK2
48breast cancer10.0CHEK2, SULT1A1, SRD5A2, GSTT1, CYP11A1, CYP17A1

Graphical network of the top 20 diseases related to Familial Prostate Cancer:



Diseases related to familial prostate cancer

Clinical Features for Familial Prostate Cancer

Sources:
47OMIM
See all sources

Clinical features from OMIM:

176807

Drugs & Therapeutics for Familial Prostate Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Familial Prostate Cancer

Drug clinical trials:

Search ClinicalTrials for Familial Prostate Cancer

Search NIH Clinical Center for Familial Prostate Cancer

Search CenterWatch for Familial Prostate Cancer

Genetic Tests for Familial Prostate Cancer

Anatomical Context for Familial Prostate Cancer

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Familial Prostate Cancer:

33
Brain, Breast, Prostate

Animal Models for Familial Prostate Cancer or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Familial Prostate Cancer

Sources:
51PubMed
See all sources

Articles related to Familial Prostate Cancer:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Clinical and histopathological characteristics of familial prostate cancer in Finland. (21507186)
2012
2
Effects of prostate-specific antigen testing on familial prostate cancer risk estimates. (20724726)
2010
3
Hereditary/familial versus sporadic prostate cancer: few indisputable genetic differences and many similar clinicopathological features. (20184087)
2010
4
Identification of a prostate cancer susceptibility gene on chromosome 5p13q12 associated with risk of both familial and sporadic disease. (18830231)
2009
5
Age at diagnosis and age at death in familial prostate cancer. (19939895)
2009
6
Effect of genetic variability within 8q24 on aggressiveness patterns at diagnosis and familial status of prostate cancer. (18765558)
2008
7
Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb. (18066601)
2008
8
Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases. (18767027)
2008
9
Further evidence for null association of phenol sulfotransferase SULT1A1 polymorphism with prostate cancer risk: a case-control study of familial prostate cancer in a Japanese population. (18368507)
2008
10
Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer. (17683075)
2007
11
Higher frequency of familial clustering of prostate cancer in French-Canadian men. (17698103)
2007
12
Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer. (17507624)
2007
13
Identification of germline MLH1 alterations in familial prostate cancer. (16963262)
2006
14
Association of the polymorphisms of genes involved in androgen metabolism and signaling pathways with familial prostate cancer risk in a Japanese population. (16859836)
2006
15
Role of the Nijmegen breakage syndrome 1 gene in familial and sporadic prostate cancer. (16702373)
2006
16
Prevalence, treatment modalities and prognosis of familial prostate cancer in a screened population. (16515992)
2006
17
Chromogranin A expression in familial versus sporadic prostate cancer. (16286114)
2005
18
Role of a CYP17 promoter polymorphism for familial prostate cancer risk in Germany. (15865082)
2005
19
Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer. (15534086)
2004
20
Genomewide linkage analysis of familial prostate cancer in the Japanese population. (14666403)
2004
21
Gluthatione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer. (15527908)
2004
22
-160C/A polymorphism in the E-cadherin gene promoter and risk of hereditary, familial and sporadic prostate cancer. (14961571)
2004
23
Association of genetic polymorphisms of glutathione-S-transferase genes (GSTM1, GSTT1 and GSTP1) with familial prostate cancer risk in a Japanese population. (12926131)
2003
24
A systematic review and meta-analysis of familial prostate cancer risk. (12780833)
2003
25
Luteinizing hormone beta polymorphism and risk of familial and sporadic prostate cancer. (12746844)
2003
26
Association of the genetic polymorphism in cytochrome P450 (CYP) 1A1 with risk of familial prostate cancer in a Japanese population: a case-control study. (12767526)
2003
27
Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer. (15040862)
2003
28
Association between the clinical presentation and epidemiological features of familial prostate cancer in patients selected for radical prostatectomy. (12767361)
2003
29
Genome linkage screen for prostate cancer susceptibility loci: results from the Mayo Clinic Familial Prostate Cancer Study. (14601030)
2003
30
Cyclin D1 gene polymorphism and familial prostate cancer: the AA genotype of A870G polymorphism is associated with prostate cancer risk in men aged 70 years or older and metastatic stage. (14981950)
2003
31
Familial prostate cancer. (11588848)
2001
32
Loss of heterozygosity of the putative prostate cancer susceptibility gene HPC2/ELAC2 is uncommon in sporadic and familial prostate cancer. (11751379)
2001
33
A randomized, controlled chemoprevention trial of selenium in familial prostate cancer: Rationale, recruitment, and design issues. (11295622)
2001
34
Evaluation of linkage and association of HPC2/ELAC2 in patients with familial or sporadic prostate cancer. (11254448)
2001
35
Genetic changes in familial prostate cancer by comparative genomic hybridization. (11170152)
2001
36
BRCA1 and BRCA2 have a limited role in familial prostate cancer. (10728701)
2000
37
Familial prostate cancer from the family-cancer database. (10741282)
2000
38
Significance of measurement of prostate specific antigen (PSA) in familial prostate cancer lines. (9607395)
1998
39
Familial prostate cancer in Japan. (9559839)
1998
40
Immunohistochemical expression of BRCA2 protein and allelic loss at the BRCA2 locus in prostate cancer. CRC/BPG UK Familial Prostate Cancer Study Collaborators. (9724085)
1998
41
Linkage analysis of chromosome 1q markers in 136 prostate cancer families. The Cancer Research Campaign/British Prostate Group U.K. Familial Prostate Cancer Study Collaborators. (9497242)
1998
42
Familial prostate cancer in four brothers. (9712452)
1998
43
Allelic imbalance in familial and sporadic prostate cancer at the putative human prostate cancer susceptibility locus, HPC1. CRC/BPG UK Familial Prostate Cancer Study Collaborators. Cancer Research Campaign/British Prostate Group. (9836474)
1998
44
Familial prostate cancer: the evidence and the Cancer Research Campaign/British Prostate Group (CRC/BPG) UK Familial Prostate Cancer Study. (9088267)
1997
45
Familial prostate cancer studies in Utah. (9088268)
1997
46
Linkage analysis of 49 high-risk families does not support a common familial prostate cancer-susceptibility gene at 1q24-25. (9311739)
1997
47
Familial prostate cancer: a different disease? (9366343)
1997
48
Familial prostate cancer in Sweden. A nationwide register cohort study. (8630920)
1996
49
Familial breast cancer risks. Effects of prostate and other cancers. (8508396)
1993
50
Mendelian inheritance of familial prostate cancer. (1565627)
1992

Genetic Variations for Familial Prostate Cancer

Expression for genes affiliated with Familial Prostate Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Familial Prostate Cancer

Search GEO for disease gene expression data for Familial Prostate Cancer.

Pathways for genes affiliated with Familial Prostate Cancer

Sources:
50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Familial Prostate Cancer according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3UGT2B15, HSD17B1
2
Hide members
10.3SULT1A1, HSD17B1
310.3CYP17A1, CYP11A1
410.3HSD17B1, AKR1C3
5
Hide members
10.2GSTT1, SULT1A1, UGT2B15
6
Hide members
10.1CYP11A1, HSD3B2, HSD3B1, CYP17A1
7
Estrone metabolism
Hide members
10.0HSD17B1, CYP17A1, HSD17B2, HSD3B2, HSD3B1
8
Hide members
10.0HSD3B2, HSD3B1, CYP17A1, SRD5A2, AKR1C3
9
Hide members
9.9CHEK2, HSD17B2, HSD17B1, HSD3B1, HSD3B2, CYP17A1
10
Hide members
9.9HSD3B2, SRD5A2, CYP11A1, HSD3B1, CYP17A1, HSD17B1
11
Hide members
9.9SULT1A1, CYP11A1, CYP17A1, GSTT1, AKR1C3, UGT2B15
129.7HSD17B2, LHB, HSD3B2, HSD3B1, CYP11A1, CYP17A1
13
Hide members
9.7HSD3B1, HSD17B1, HSD3B2, CYP17A1, UGT2B15, AKR1C3
14
Hide members
9.5CYP11A1, CYP17A1, CDS1, HSD17B2, AMACR, HSD3B2

Compounds for genes affiliated with Familial Prostate Cancer

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Familial Prostate Cancer according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
120alpha-hydroxycholesterol45 2411.6CYP17A1, CYP11A1
2deoxycorticosterone29 2411.6HSD3B1, HSD3B2
32-naphthol4510.6SULT1A1, GSTT1
4campesterol45 2411.6HSD3B2, HSD3B1
54-Androstenedione1110.6AKR1C3, HSD17B1, HSD3B1
6acth 1-244510.6CYP17A1, CYP11A1
75alpha-dihydroprogesterone4510.6AKR1C3, SRD5A2
8estriol29 11 2412.6HSD17B1, HSD17B2, UGT2B15
9medroxyprogesterone45 50 29 11 2414.6HSD3B2, CYP11A1
10trilostane45 1111.5HSD3B1, HSD3B2
11cortisol29 2411.5HSD3B1, HSD3B2
12dihydroprogesterone4510.5HSD17B2, AKR1C3, CYP11A1
13dehydroepiandrosterone sulfate4510.5CYP11A1, HSD3B2, CYP17A1
14Dehydroepiandrosterone11 2411.5CYP17A1, HSD3B2, HSD17B1, HSD3B1
15Pregnenolone11 2411.5CYP17A1, HSD3B2, CYP11A1, HSD3B1
16hydrocarbons4510.5AKR1C3, GSTT1, SULT1A1
17dhea4510.5HSD3B2, CYP11A1, CYP17A1, SULT1A1
18arylamine4510.5SULT1A1, GSTT1
19androstanedione45 11 2412.5HSD17B1, SRD5A2
2017-hydroxypregnenolone4510.4HSD3B2, CYP17A1
21hydroxysteroid4510.4HSD17B1, HSD17B2, SULT1A1, CYP17A1, CYP11A1
2217-hydroxyprogesterone45 2411.4HSD17B2, CYP11A1, CYP17A1, HSD3B2, HSD3B1
233beta-hydroxysteroid4510.4CYP17A1, SRD5A2, CYP11A1, HSD3B2, HSD3B1
24aminopyrine4510.4CYP17A1, CYP11A1
25estrone45 29 11 2413.4HSD17B1, CYP17A1, AKR1C3, UGT2B15, HSD17B2
26ribonucleic acid4510.4CYP11A1, CYP17A1, RNASEL, SRD5A2
27nad29 2411.3HSD17B2, HSD3B1, HSD3B2, HSD17B1, AKR1C3
28doca4510.3CYP11A1, CYP17A1
2911beta-hydroxysteroid4510.3HSD17B1, AKR1C3, AMACR, CYP17A1, CYP11A1, HSD3B2
30bpde4510.3CHEK2, GSTT1
31nadh45 11 2412.3HSD17B1, AKR1C3, CYP17A1, HSD17B2, HSD3B2, HSD3B1
32dihydrotestosterone45 29 11 2413.2UGT2B15, HSD3B2, HSD17B1, AKR1C3, CYP17A1, CYP11A1
3317beta-hydroxysteroid4510.2SRD5A2, CYP11A1, CYP17A1, HSD17B2, AKR1C3, HSD3B2
34cholesterol45 29 11 2413.2SULT1A1, CYP11A1, CYP17A1, AMACR, HSD3B1, HSD3B2
35androstenedione45 2411.2AKR1C3, SRD5A2, CYP11A1, CYP17A1, HSD3B2, HSD3B1
36oligonucleotide4510.2AMACR, HSD3B2, CHEK2, CYP17A1, RNASEL, SULT1A1
37bisphenol a4510.2SULT1A1, CYP17A1
38retinoic acid45 2411.2HSD17B2, CYP11A1, AMACR, UGT2B15, NKX3-1, CYP17A1
39oxygen45 2411.2RNASEL, CHEK2, CYP11A1, CYP17A1, MSR1, GSTT1
40estradiol45 11 2412.1SRD5A2, UGT2B15, HSD17B1, SULT1A1, CYP11A1, CYP17A1
41arginine4510.0GSTT1, CYP17A1, RNASEL, SULT1A1, SRD5A2
42nadph45 2410.9SRD5A2, SULT1A1, HSD17B2, CYP17A1, AKR1C3, HSD17B1
43adenine45 11 2411.9SULT1A1, SRD5A2, RNASEL
44progesterone45 60 29 11 2413.8AMACR, HSD17B2, HSD17B1, NKX3-1, HSD3B2, AKR1C3
45steroid459.8CYP11A1, HSD3B2, HSD3B1, HSD17B1, GSTT1, SRD5A2
46testosterone45 60 11 2412.7SRD5A2, HSD3B2, HSD3B1, HSD17B2, NKX3-1, AMACR

GO Terms for genes affiliated with Familial Prostate Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Familial Prostate Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1smooth endoplasmic reticulum membraneGO:03086810.3HSD3B1, HSD3B2
2endoplasmic reticulum membraneGO:0057899.5SRD5A2, CYP17A1, CDS1, UGT2B15, HSD17B2, HSD3B1

Biological processes related to Familial Prostate Cancer according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1response to insecticideGO:01708510.6CYP17A1, CYP11A1
2dibenzo-p-dioxin metabolic processGO:01889410.6CYP17A1, CYP11A1
3response to fungicideGO:06099210.5CYP11A1, CYP17A1
4biphenyl metabolic processGO:01887910.5CYP17A1, CYP11A1
5mineralocorticoid biosynthetic processGO:00670510.5HSD3B1, HSD3B2
6glucocorticoid biosynthetic processGO:00670410.5HSD3B1, CYP17A1, HSD3B2
7estrogen biosynthetic processGO:00670310.5CYP11A1, HSD17B1, HSD3B1
8testosterone biosynthetic processGO:06137010.5CYP11A1, HSD17B1, AKR1C3
9phthalate metabolic processGO:01896310.5CYP17A1, CYP11A1
10phenol-containing compound metabolic processGO:01895810.5CYP11A1, CYP17A1
11progesterone biosynthetic processGO:00670110.5CYP11A1, LHB
12androgen biosynthetic processGO:00670210.4HSD3B1, CYP17A1, HSD3B2, SRD5A2
13progesterone metabolic processGO:04244810.4AKR1C3, CYP17A1
14male gonad developmentGO:00858410.4SRD5A2, LHB, AKR1C3, NKX3-1
15cellular response to antibioticGO:07123610.4CYP17A1, CYP11A1
16estrogen metabolic processGO:00821010.4SULT1A1, HSD17B1
17steroid biosynthetic processGO:00669410.4CYP17A1, HSD3B2, HSD17B2, HSD17B1, HSD3B1
18xenobiotic metabolic processGO:00680510.3SULT1A1, GSTT1, CYP11A1, CYP17A1, UGT2B15
19Leydig cell differentiationGO:03332710.3CYP17A1, CYP11A1
20positive regulation of cell deathGO:01094210.3AKR1C3, NKX3-1
21cellular response to cadmium ionGO:07127610.2CYP11A1, AKR1C3
22steroid metabolic processGO:00820210.1AKR1C3, CYP17A1, CYP11A1, SRD5A2, UGT2B15, HSD17B1
23sterol metabolic processGO:01612510.0CYP17A1, CYP11A1
24small molecule metabolic processGO:0442819.7HSD3B1, HSD17B1, HSD3B2, GSTT1, SRD5A2, SULT1A1

Molecular functions related to Familial Prostate Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid delta-isomerase activityGO:00476910.3HSD3B1, HSD3B2
2estradiol 17-beta-dehydrogenase activityGO:00430310.3HSD17B2, HSD17B1
3testosterone dehydrogenase (NAD+) activityGO:04703510.2AKR1C3, HSD17B2
43-beta-hydroxy-delta5-steroid dehydrogenase activityGO:00385410.0HSD3B1, HSD3B2

Products for genes affiliated with Familial Prostate Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Familial Prostate Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet