MCID: FML085
MIFTS: 50

Familial Prostate Cancer malady

Genetic diseases, Rare diseases, Cancer diseases categories
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Summaries for Familial Prostate Cancer

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47OMIM, 33MalaCards
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MalaCards: Familial Prostate Cancer, also known as prostate cancer, familial, is related to prostate cancer and breast cancer. An important gene associated with Familial Prostate Cancer is CDS1 (CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1), and among its related pathways are Valproic Acid Pathway, Pharmacokinetics and Glioma. The compounds estriol and 16a-Hydroxydehydroisoandrosterone have been mentioned in the context of this disorder. Affiliated tissues include prostate, breast and testes, and related mouse phenotypes are tumorigenesis and cellular.

Description from OMIM:47 176807

Aliases & Classifications for Familial Prostate Cancer

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43NIH Rare Diseases, 47OMIM, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases


Aliases & Descriptions:

familial prostate cancer 43
prostate cancer, familial 43 47 62
prostate cancer, hereditary 43 47
malignant neoplasm of prostate 62
hereditary prostate cancer 43


Related Diseases for Familial Prostate Cancer

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17GeneCards, 18GeneDecks
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Diseases in the Prostate Cancer family:

Prostate Carcinoma in Situ familial prostate cancer
Prostate Cancer 1 Prostate Cancer, Hereditary, 12
Prostate Cancer, Hereditary, 5 Prostate Cancer 4
Prostate Cancer, Hereditary, 10 Prostate Cancer, Hereditary, 13
Prostate Cancer, Hereditary, 14 Prostate Cancer, Hereditary, 7
Prostate Cancer, Hereditary, 2 Prostate Cancer, Hereditary, 11
Prostate Cancer, Hereditary, 9 Prostate Cancer, Hereditary, 15
Prostate Cancer 3

Diseases related to Familial Prostate Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1prostate cancer31.3EPHB2, MXI1, CHEK2, PTEN
2breast cancer30.0HSD17B1, RNASEL, AMACR, PTEN, SRD5A2, MXI1
3prostatitis11.0
4prostate cancer, progression and metastasis of10.3
5prostate cancer 110.2
6prostate cancer, hereditary, 1210.2
7prostate cancer, hereditary, 510.2
8prostate cancer, hereditary, 1010.2
9prostate cancer, hereditary, 1310.2
10prostate cancer, hereditary, 1410.2
11prostate cancer, hereditary, 710.2
12prostate cancer, hereditary, 210.2
13prostate cancer, hereditary, 1110.2
14prostate cancer, hereditary, 910.2
15prostate cancer, hereditary, 1510.2
16prostate cancer, hereditary, x-linked 210.2
17prostate cancer, hereditary, x-linked 110.2
18penis agenesis10.1CYP17A1, SRD5A2
19bilateral breast cancer10.1
20lynch syndrome10.1
21gynecomastia10.1CYP17A1, SRD5A2
22congenital adrenal hyperplasia10.0CYP17A1, HSD3B2, HSD3B1
23hyperandrogenism10.0HSD3B1, HSD3B2, CYP17A1
24polycystic ovary syndrome10.0HSD3B2, HSD3B1, CYP17A1
25leydig cell tumor10.0CYP17A1, HSD3B1
26addison's disease10.0CYP17A1, HSD3B2
27pseudohermaphroditism10.0SRD5A2, HSD3B1, CYP17A1, HSD3B2
28hypospadias10.0CYP17A1, SRD5A2, HSD3B2, HSD3B1
29li-fraumeni syndrome10.0CHEK2, PTEN
30endometriosis10.0HSD17B1, PTEN, CYP17A1
31lipoma10.0AMACR, PTEN
32brain cancer9.9MXI1, PTEN, EPHB2
33stomach cancer9.9PTEN, AMACR, CHEK2
34glioblastoma multiforme9.9CHEK2, MXI1, EPHB2, PTEN
35adenocarcinoma9.9MSMB, PTEN, NKX3-1, AMACR, MXI1, CHEK2
36colorectal cancer9.9AMACR, CHEK2, PTEN, CYP17A1, EPHB2
37colon cancer9.8CYP17A1, PTEN, AMACR, EPHB2, CHEK2
38ovarian cancer9.7HSD17B1, PTEN, CHEK2, AMACR, SRD5A2, MSR1

Graphical network of the top 20 diseases related to Familial Prostate Cancer:



Diseases related to familial prostate cancer

Symptoms for Familial Prostate Cancer

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47OMIM
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Clinical features from OMIM:

176807

Drugs & Therapeutics for Familial Prostate Cancer

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Familial Prostate Cancer

Search NIH Clinical Center for Familial Prostate Cancer

Genetic Tests for Familial Prostate Cancer

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Anatomical Context for Familial Prostate Cancer

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33MalaCards
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MalaCards organs/tissues related to Familial Prostate Cancer:

33
Prostate, Breast, Testes

Animal Models for Familial Prostate Cancer or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Familial Prostate Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5MXI1, NKX3-1, MSMB, CHEK2, PTEN
2MP:00053848.2CHEK2, RNASEL, NKX3-1, MXI1, PTEN, LHB
3MP:00107688.0MXI1, NKX3-1, MSR1, CHEK2, EPHB2, AMACR
4MP:00053797.3NKX3-1, SRD5A2, MSMB, EPHB2, PTEN, LHB
5MP:00053897.0MXI1, HOXB13, CYP17A1, LHB, PTEN, EPHB2

Publications for Familial Prostate Cancer

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52PubMed
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Articles related to Familial Prostate Cancer:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Familial prostate cancer: the damage done and lessons learnt. (23318356)
2013
2
Confirmation of the HOXB13 G84E germline mutation in familial prostate cancer. (22714738)
2012
3
Clinical and histopathological characteristics of familial prostate cancer in Finland. (21507186)
2012
4
Mutation analysis of the MSMB gene in familial prostate cancer. (19997100)
2010
5
Association of SNP rs1447295 and microsatellite marker DG8S737 with familial prostate cancer and high grade disease. (20639049)
2010
6
Identification of a novel germline missense mutation of the androgen receptor in African American men with familial prostate cancer. (20173765)
2010
7
Effects of prostate-specific antigen testing on familial prostate cancer risk estimates. (20724726)
2010
8
Is a retrovirus implicated in familial prostate cancer? (19436028)
2009
9
Chromosome 8q24 markers: risk of early-onset and familial prostate cancer. (18360876)
2008
10
Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb. (18066601)
2008
11
Further evidence for null association of phenol sulfotransferase SULT1A1 polymorphism with prostate cancer risk: a case-control study of familial prostate cancer in a Japanese population. (18368507)
2008
12
Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer. (17683075)
2007
13
Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer. (17507624)
2007
14
Aggressiveness of familial prostate cancer. (16849760)
2006
15
Identification of germline MLH1 alterations in familial prostate cancer. (16963262)
2006
16
Association of the polymorphisms of genes involved in androgen metabolism and signaling pathways with familial prostate cancer risk in a Japanese population. (16859836)
2006
17
Alcohol drinking and risk of localized versus advanced and sporadic versus familial prostate cancer in Sweden. (15947879)
2005
18
Role of a CYP17 promoter polymorphism for familial prostate cancer risk in Germany. (15865082)
2005
19
Genomewide linkage analysis of familial prostate cancer in the Japanese population. (14666403)
2004
20
Association of genetic polymorphisms of glutathione-S-transferase genes (GSTM1, GSTT1 and GSTP1) with familial prostate cancer risk in a Japanese population. (12926131)
2003
21
A systematic review and meta-analysis of familial prostate cancer risk. (12780833)
2003
22
Vitamin D receptor gene polymorphism in familial prostate cancer in a Japanese population. (12694466)
2003
23
Association of the genetic polymorphism in cytochrome P450 (CYP) 1A1 with risk of familial prostate cancer in a Japanese population: a case-control study. (12767526)
2003
24
Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer. (15040862)
2003
25
Familial prostate cancer cases before and after radical prostatectomy do not show any aggressiveness compared with sporadic cases. (12809896)
2003
26
Association between the clinical presentation and epidemiological features of familial prostate cancer in patients selected for radical prostatectomy. (12767361)
2003
27
Genome linkage screen for prostate cancer susceptibility loci: results from the Mayo Clinic Familial Prostate Cancer Study. (14601030)
2003
28
Cyclin D1 gene polymorphism and familial prostate cancer: the AA genotype of A870G polymorphism is associated with prostate cancer risk in men aged 70 years or older and metastatic stage. (14981950)
2003
29
African American men and hereditary/familial prostate cancer: Intermediate-risk populations for chemoprevention trials. (11295621)
2001
30
Regression models for linkage heterogeneity applied to familial prostate cancer. (11309684)
2001
31
Familial prostate cancer. (11588848)
2001
32
Loss of heterozygosity of the putative prostate cancer susceptibility gene HPC2/ELAC2 is uncommon in sporadic and familial prostate cancer. (11751379)
2001
33
BRCA1 and BRCA2 have a limited role in familial prostate cancer. (10728701)
2000
34
Suggestive evidence for a site specific prostate cancer gene on chromosome 1p36. The CRC/BPG UK Familial Prostate Cancer Study Coordinators and Collaborators. The EU Biomed Collaborators. (11186936)
2000
35
No evidence of germline PTEN mutations in familial prostate cancer. (10777362)
2000
36
Hereditary and familial prostate cancer: biologic aggressiveness and recurrence. (16985733)
2000
37
Familial prostate cancer from the family-cancer database. (10741282)
2000
38
Familial prostate cancer: outcome following radiation therapy with or without adjuvant androgen ablation. (10030265)
1999
39
Significance of measurement of prostate specific antigen (PSA) in familial prostate cancer lines. (9607395)
1998
40
Familial prostate cancer in Japan. (9559839)
1998
41
Familial prostate cancer and possible associated malignancies: nation-wide register cohort study in Sweden. (9766560)
1998
42
Immunohistochemical expression of BRCA2 protein and allelic loss at the BRCA2 locus in prostate cancer. CRC/BPG UK Familial Prostate Cancer Study Collaborators. (9724085)
1998
43
Linkage analysis of chromosome 1q markers in 136 prostate cancer families. The Cancer Research Campaign/British Prostate Group U.K. Familial Prostate Cancer Study Collaborators. (9497242)
1998
44
Familial prostate cancer: the evidence and the Cancer Research Campaign/British Prostate Group (CRC/BPG) UK Familial Prostate Cancer Study. (9088267)
1997
45
Familial prostate cancer studies in Utah. (9088268)
1997
46
Linkage analysis of 49 high-risk families does not support a common familial prostate cancer-susceptibility gene at 1q24-25. (9311739)
1997
47
No germline mutations in the dimerization domain of MXI1 in prostate cancer clusters. The CRC/BPG UK Familial Prostate Cancer Study Collaborators. Cancer Research Campaign/British Prostate Group. (9376279)
1997
48
Familial prostate cancer in Sweden. A nationwide register cohort study. (8630920)
1996
49
Androgen receptor and familial prostate cancer. (7585194)
1995
50
Mendelian inheritance of familial prostate cancer. (1565627)
1992

Variations for Familial Prostate Cancer

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Sources:
64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Familial Prostate Cancer:

64 (show all 42)
id Symbol AA change Variation ID SNP ID
1CHEK2p.Arg180CysVAR_019103rs77130927
2CHEK2p.Arg180CysVAR_019103rs77130927
3CHEK2p.Arg181CysVAR_019104rs137853010
4CHEK2p.Arg181CysVAR_019104rs137853010
5CHEK2p.Arg181HisVAR_019105rs121908701
6CHEK2p.Arg181HisVAR_019105rs121908701
7CHEK2p.Glu239LysVAR_019106
8CHEK2p.Glu239LysVAR_019106
9CHEK2p.Glu64LysVAR_019107
10CHEK2p.Glu64LysVAR_019107
11CHEK2p.Arg145ProVAR_019108
12CHEK2p.Arg145ProVAR_019108
13CHEK2p.Gly167ArgVAR_019109
14CHEK2p.Gly167ArgVAR_019109
15CHEK2p.Arg180HisVAR_019110rs137853009
16CHEK2p.Arg180HisVAR_019110rs137853009
17CHEK2p.Ile251PheVAR_019111
18CHEK2p.Ile251PheVAR_019111
19CHEK2p.Arg318HisVAR_019112rs143611747
20CHEK2p.Arg318HisVAR_019112rs143611747
21CHEK2p.Thr323ProVAR_019113
22CHEK2p.Thr323ProVAR_019113
23CHEK2p.Tyr327CysVAR_019114
24CHEK2p.Tyr327CysVAR_019114
25CHEK2p.Thr476LysVAR_019115
26CHEK2p.Thr476LysVAR_019115
27EPHB2p.Arg199HisVAR_032853
28EPHB2p.Arg199HisVAR_032853
29EPHB2p.Ala279SerVAR_032854rs35882952
30EPHB2p.Ala279SerVAR_032854rs35882952
31EPHB2p.Val650AlaVAR_032855rs142173175
32EPHB2p.Val650AlaVAR_032855rs142173175
33EPHB2p.His679AsnVAR_032856
34EPHB2p.His679AsnVAR_032856
35EPHB2p.Met883ValVAR_032857
36EPHB2p.Met883ValVAR_032857
37EPHB2p.Ile909MetVAR_032858
38EPHB2p.Ile909MetVAR_032858
39MXI1p.Glu152AlaVAR_004499
40MXI1p.Glu152AlaVAR_004499
41PTENp.Met134LeuVAR_007469
42PTENp.Met134LeuVAR_007469

Clinvar genetic disease variations for Familial Prostate Cancer:

1 (show all 16)
id Gene Name Type Significance SNP ID Assembly Location
1MSR1NM_138715.2(MSR1): c.877C> T (p.Arg293Ter)single nucleotide variantPathogenicrs41341748GRCh37Chr 8, 16012594: 16012594
2MSR1NM_138715.2(MSR1): c.520G> T (p.Asp174Tyr)single nucleotide variantPathogenicrs72552387GRCh37Chr 8, 16026077: 16026077
3ZFHX3ZFHX3, 24-BP DEL, NT10814deletionPathogenic
4CHEK2NM_007194.3(CHEK2): c.470T> C (p.Ile157Thr)single nucleotide variantLikely pathogenic, Pathogenic, risk factorrs17879961GRCh37Chr 22, 29121087: 29121087
5BRCA2BRCA2, 1-BP DEL, 6051AdeletionPathogenic
6BRCA2BRCA2, 1-BP INS, 2558AinsertionPathogenic
7MXI1MXI1, 1-BP DEL, A, CODON 140 OR 141deletionPathogenic
8MXI1NM_130439.3(MXI1): c.552+2T> Csingle nucleotide variantPathogenicrs387906417GRCh37Chr 10, 112039054: 112039054
9MXI1NM_130439.3(MXI1): c.656A> C (p.Glu219Ala)single nucleotide variantPathogenicrs137852603GRCh37Chr 10, 112039775: 112039775
10ARNM_000044.3(AR): c.1943G> A (p.Ser648Asn)single nucleotide variantPathogenicrs137852584GRCh37Chr X, 66931301: 66931301
11ARNM_000044.3(AR): c.2191G> A (p.Val731Met)single nucleotide variantPathogenicrs137852571GRCh37Chr X, 66937337: 66937337
12ARNM_000044.3(AR): c.2632A> G (p.Thr878Ala)single nucleotide variantPathogenicrs137852578GRCh37Chr X, 66943552: 66943552
13ARNM_000044.3(AR): c.2633C> G (p.Thr878Ser)single nucleotide variantPathogenicrs137852580GRCh37Chr X, 66943553: 66943553
14ARNM_000044.3(AR): c.2623C> T (p.His875Tyr)single nucleotide variantPathogenicrs137852581GRCh37Chr X, 66943543: 66943543
15ARNM_000044.3(AR): c.2708A> G (p.Gln903Arg)single nucleotide variantPathogenicrs137852582GRCh37Chr X, 66943628: 66943628
16ARNM_000044.3(AR): c.2164G> A (p.Ala722Thr)single nucleotide variantPathogenicrs137852583GRCh37Chr X, 66931522: 66931522

Expression for genes affiliated with Familial Prostate Cancer

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Familial Prostate Cancer

Search GEO for disease gene expression data for Familial Prostate Cancer.

Pathways for genes affiliated with Familial Prostate Cancer

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50PathCards, 51PharmGKB, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome
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Pathways related to Familial Prostate Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8HSD17B1, UGT2B15
2
Show member pathways
Signaling Pathways in Glioblastoma38
9.0PTEN, SRD5A2, NKX3-1
3
Show member pathways
Estrogen biosynthesis60
Androstenedione and testosterone biosynthesis and metabolism p.160
8.7HSD3B2, HSD17B1, HSD3B1, CYP17A1
4
Show member pathways
estradiol biosynthesis II38
androgen biosynthesis38
estradiol biosynthesis I38
progesterone biosynthesis38
8.4HSD17B1, CYP17A1, SRD5A2, HSD3B1
58.4HSD3B2, HSD17B1, HSD3B1, LHB, CYP17A1
6
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
8.3CHEK2, PTEN, HSD3B2, CYP17A1, HSD17B1, HSD3B1
7
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism38
7.6UGT2B15, CYP17A1, HSD3B1, HSD3B2, SRD5A2, HSD17B1
8
Show member pathways
7.6HSD3B2, SRD5A2, HSD17B1, HSD3B1, LHB, CYP17A1
9
Show member pathways
6.3UGT2B15, CYP17A1, LHB, HSD3B1, HSD17B1, HSD3B2

Compounds for genes affiliated with Familial Prostate Cancer

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Sources:
29IUPHAR, 24HMDB, 11DrugBank, 45Novoseek, 61Tocris Bioscience
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Compounds related to Familial Prostate Cancer according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1estriol29 24 1111.9HSD17B1, UGT2B15
216a-Hydroxydehydroisoandrosterone249.9HSD3B1, HSD3B2
316a-Hydroxyandrost-4-ene-3,17-dione249.9HSD3B2, HSD3B1
4Campest-4-en-3-one249.9HSD3B1, HSD3B2
521-Hydroxypregnenolone249.9HSD3B1, HSD3B2
6hydroxysteroid459.9CYP17A1, HSD17B1
711b,17a,21-Trihydroxypreg-nenolone249.9HSD3B2, HSD3B1
817a,21-Dihydroxypreg-nenolone249.9HSD3B1, HSD3B2
9Androst-5-ene-3b,17b-diol249.8HSD3B1, HSD3B2
10deoxycorticosterone29 2410.8HSD3B1, HSD3B2
11Cortexolone249.8HSD3B2, HSD3B1
12campesterol45 2410.8HSD3B1, HSD3B2
13cortisol29 2410.8HSD3B2, HSD3B1
1417-hydroxypregnenolone459.8HSD3B2, CYP17A1
15trilostane45 1110.8HSD3B1, HSD3B2
16estrone45 29 24 1112.6CYP17A1, HSD17B1, UGT2B15
17streptavidin459.6AMACR, PTEN
18androstanedione45 24 1111.6SRD5A2, HSD17B1
1917a-Hydroxypregnenolone249.5CYP17A1, HSD3B1, HSD3B2
20Pregnenolone24 1110.5HSD3B1, CYP17A1, HSD3B2
21magnesium45 24 1111.5RNASEL, CHEK2, CDS1, PTEN
2217-hydroxyprogesterone45 2410.5CYP17A1, HSD3B2, HSD3B1
23pd 98,059459.3CYP17A1, HSD3B2, PTEN, EPHB2
24oxygen45 2410.3CHEK2, PTEN, CYP17A1, MSR1, RNASEL
25cycloheximide459.3RNASEL, UGT2B15, CYP17A1, PTEN
26deoxyribonucleic acid459.2AMACR, PTEN, SRD5A2
27Dehydroepiandrosterone24 1110.2CYP17A1, HSD3B2, HSD3B1, HSD17B1
28NADP249.1HSD3B2, HSD17B1, CYP17A1, HSD3B1
2911beta-hydroxysteroid459.1AMACR, HSD17B1, HSD3B2, CYP17A1
30nadh45 24 1111.1CYP17A1, HSD3B1, HSD17B1, HSD3B2
31ribonucleic acid459.0CYP17A1, RNASEL, SRD5A2
32leucine458.9SRD5A2, PTEN, MXI1, CYP17A1
33nad29 249.9HSD17B1, HSD3B1, HSD3B2
34Testosterone sulfate248.8UGT2B15, SRD5A2, HSD3B2, HSD3B1
3517beta-hydroxysteroid458.8SRD5A2, CYP17A1, HSD17B1, HSD3B2
36vitamin d458.8AMACR, SRD5A2, CYP17A1, PTEN
37estradiol45 24 1110.7CYP17A1, SRD5A2, PTEN, HSD17B1, UGT2B15
38arginine458.7PTEN, CYP17A1, EPHB2, SRD5A2, RNASEL
393beta-hydroxysteroid458.7CYP17A1, HSD3B1, HSD3B2, SRD5A2
40androstenedione45 249.7SRD5A2, HSD3B1, HSD3B2, CYP17A1
41oligonucleotide458.7CHEK2, PTEN, RNASEL, AMACR, CYP17A1, HSD3B2
42retinoic acid45 249.6NKX3-1, CHEK2, CYP17A1, EPHB2, AMACR, PTEN
43cholesterol45 29 24 1111.5AMACR, CYP17A1, HSD3B2, HSD3B1, MSR1, PTEN
44dihydrotestosterone45 29 24 1111.5SRD5A2, UGT2B15, CYP17A1, HSD3B2, HSD17B1
45nadph45 249.3SRD5A2, HSD3B2, HSD17B1, HSD3B1, CYP17A1
46tyrosine458.1UGT2B15, CYP17A1, PTEN, AMACR, MSR1, CHEK2
47estrogen457.3HSD3B1, CYP17A1, HSD17B1, UGT2B15, HSD3B2, AMACR
48progesterone45 29 61 24 1111.2HSD17B1, HSD3B2, CYP17A1, HSD3B1, NKX3-1, SRD5A2
49steroid457.2PTEN, UGT2B15, CYP17A1, HSD17B1, HSD3B2, MSMB
50testosterone45 61 24 118.8SRD5A2, HSD3B1, HSD17B1, HSD3B2, AMACR, RNASEL

GO Terms for genes affiliated with Familial Prostate Cancer

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16Gene Ontology
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Cellular components related to Familial Prostate Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1smooth endoplasmic reticulum membraneGO:0308689.5HSD3B2, HSD3B1
2endoplasmic reticulum membraneGO:0057897.5CDS1, SRD5A2, HSD3B2, HSD3B1, CYP17A1, UGT2B15

Biological processes related to Familial Prostate Cancer according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1dendritic spine morphogenesisGO:06099710.2PTEN, EPHB2
2negative regulation of axonogenesisGO:05077110.0EPHB2, PTEN
3response to testosteroneGO:0335749.8NKX3-1, HOXB13
4estrogen biosynthetic processGO:0067039.8HSD3B1, HSD17B1
5positive regulation of apoptotic signaling pathwayGO:20012359.7PTEN, NKX3-1
6angiogenesisGO:0015259.7EPHB2, PTEN, HOXB13
7mineralocorticoid biosynthetic processGO:0067059.7HSD3B2, HSD3B1
8protein kinase B signalingGO:0434919.5PTEN, NKX3-1
9glucocorticoid biosynthetic processGO:0067049.3HSD3B2, HSD3B1, CYP17A1
10male gonad developmentGO:0085849.1NKX3-1, SRD5A2, LHB
11steroid biosynthetic processGO:0066949.0CYP17A1, HSD3B1, HSD17B1, HSD3B2
12androgen biosynthetic processGO:0067028.5CYP17A1, HSD3B1, HSD3B2, SRD5A2
13steroid metabolic processGO:0082027.9SRD5A2, HSD3B2, HSD17B1, HSD3B1, CYP17A1, UGT2B15
14small molecule metabolic processGO:0442817.2CYP17A1, HSD3B1, HSD17B1, HSD3B2, PTEN, AMACR

Molecular functions related to Familial Prostate Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
13-beta-hydroxy-delta5-steroid dehydrogenase activityGO:0038549.5HSD3B2, HSD3B1
2steroid delta-isomerase activityGO:0047699.2HSD3B2, HSD3B1

Products for genes affiliated with Familial Prostate Cancer

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Sources for Familial Prostate Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet