Fanconi Anemia, Complementation Group a malady

MalaCards: Fanconi Anemia, Complementation Group a, also known as fanconi anemia, is related to fanconi's anemia and breast cancer. An important gene associated with Fanconi Anemia, Complementation Group a is FANCA (Fanconi anemia, complementation group A), and among its related pathways are Fanconi Anemia pathway and DNA Repair Mechanisms. The compounds mitomycin c and diepoxybutane have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and endocrine/exocrine gland.

OMIM: 227650

fanconi anemia, complementation group a 33 fanconi anemia 43

Disease types for fanconi anemia, complementation group m family:

fanconi anemia, complementation group j	fanconi anemia, complementation group 0
fanconi anemia, complementation group n	fanconi anemia, complementation group a
fanconi anemia, complementation group l	fanconi anemia, complementation group i

Diseases related to fanconi anemia, complementation group a by text searches and GeneDecks gene sharing:

(show top 50)    (show all 74)

id	Related Disease	Score	Top Affiliating Genes
1	fanconi's anemia	34.8	FANCG, FANCA
2	breast cancer	32.4	FANCA, FANCG
3	anemia	32.3	FANCA, FANCG, CASP3, SNX5, PSAP
4	fanconi anemia, complementation group m	31.5	FANCA, FANCG
5	fanconi anemia, complementation group b	31.0	FANCA, FANCG
6	squamous cell carcinoma	29.9	FANCA, FANCG, CASP3
7	bloom syndrome	29.7	CASP3, FANCG, FANCA
8	breast cancer susceptibility	28.8	FANCA, FANCG
9	pancytopenia	28.2	FANCA, FANCG
10	oral squamous cell carcinoma	27.2	FANCA, FANCG, CASP3
11	familial pancreatic cancer	12.7	FANCG, FANCA
12	hereditary pancreatitis	12.6	FANCA, FANCG
13	krabbe disease	12.4	CASP3, PSAP
14	hereditary breast ovarian cancer	12.4	FANCG, FANCA
15	pick's disease	12.3	PSAP, CASP3
16	squamous cell carcinoma of the head and neck	12.2	FANCA, FANCG, CASP3
17	epithelial ovarian cancer	12.1	FANCA, FANCG, CASP3
18	protein s deficiency	12.0	CASP3, PSAP
19	leukemia	8.9
20	carcinoma	8.7
21	fanconi anemia, complementation group i	8.0
22	fanconi anemia, complementation group j	8.0
23	fanconi anemia, complementation group n	7.6
24	fanconi anemia, complementation group d1	7.6
25	fanconi anemia, complementation group l	7.6
26	fanconi anemia, complementation group g	7.6
27	brca2-related fanconi anemia	7.6
28	fanconi anemia, complementation group 0	7.6
29	brip1-related fanconi anemia	7.6
30	myeloid leukemia	7.6
31	fanca-related fanconi anemia	7.6
32	palb2-related fanconi anemia	7.6
33	fancb-related fanconi anemia	7.6
34	pancreatic cancer	7.6
35	fancc-related fanconi anemia	7.6
36	pancreatitis	7.6
37	fancd2-related fanconi anemia	7.6
38	rad51c-related fanconi anemia	7.6
39	fance-related fanconi anemia	7.6
40	slx4-related fanconi anemia	7.6
41	fancf-related fanconi anemia	7.6
42	fancg-related fanconi anemia	7.6
43	fanci-related fanconi anemia	7.6
44	fancl-related fanconi anemia	7.6
45	fancm-related fanconi anemia	7.6
46	acute myeloid leukemia	7.1
47	fanconi syndrome	7.1
48	ovarian cancer	7.1
49	alcoholism	6.2
50	myeloid malignancy	6.2

Clinical features from OMIM: 227650

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to fanconi anemia, complementation group a:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	reproductive system phenotype	MP:0005389	8.1	FANCA, FANCG, CASP3, PSAP
2	endocrine/exocrine gland phenotype	MP:0005379	7.8	FANCA, FANCG, CASP3, PSAP

Articles related to fanconi anemia, complementation group a:

id	Title	Authors	Year	Affiliating Genes
1	Validation of Fanconi anemia complementation Group A assignment using molecular analysis. (19367192)	Moghrabi N.N.... Richards C.S.	2009	FANCA
2	Fanconi anemia complementation group A cells are hype rsensitive to chromium(VI)-induced toxicity. (12426130)	Vilcheck S.K.... Patierno S.R.	2002	CASP3
3	Functional analysis of the putative peroxidase domain of FANCA, the Fanconi anemia complementation group A protein. (11161829)	Ren J.... Youssoufian H.	2001	FANCA, PSAP, FANCG
4	SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein. (10600472)	Otsuki T.... Liu J.M.	1999	FANCA, PSAP, SNX5
5	Intracellular localization of the Fanconi anemia complementation group A protein. (10364463)	Walsh C.E.... Simpson D.A.	1999	FANCA, PSAP
6	A deficiency in a 230 kDa DNA repair protein in fanconi anemia complementation group A cells is corrected by the FANCA cDNA. (10469633)	Brois D.W.... Lambert M.W.	1999	FANCA
7	The Fanconi anemia complementation group A protein contains a peroxidase domain. (9608546)	Mian I.S.... Moser M.J.	1998	PSAP

Genes related to fanconi anemia, complementation group a according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	FANCA	Fanconi anemia, complementation group A	11.1	Transcripts, Publications, Aliases & Descriptions, Orthologs
2	SNX5	sorting nexin 5	11.1	Publications, Summaries
3	FANCG	Fanconi anemia, complementation group G	11.0	Publications
4	PSAP	prosaposin	11.0	Publications
5	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0	Publications

Pathways related to fanconi anemia, complementation group a according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Fanconi Anemia pathway38	9.4	FANCA, FANCG
2	DNA Repair Mechanisms36	9.4	FANCA, FANCG
3	Fanconis Anaemia Pathway36	9.3	FANCA, FANCG
4	BRCA1 Pathway36	9.1	FANCA, FANCG

Compounds related to fanconi anemia, complementation group a according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	mitomycin c32	9.4	FANCA, FANCG
2	diepoxybutane32	9.3	FANCA, FANCG
3	cisplatin32 34 9 9	11.6	FANCA, FANCG, CASP3

Cellular components related to fanconi anemia, complementation group a according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Fanconi anaemia nuclear complex	GO:043240	9.4	FANCA, FANCG

Biological processes related to fanconi anemia, complementation group a according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to organic substance	GO:071310	9.1	CASP3, PSAP