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MCID: FNC032

Fanconi Anemia, Complementation Group B malady
8 genes, 64 related diseases, clinical trials.

Summaries for Fanconi Anemia, Complementation Group B

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43OMIM, 29MalaCards
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MalaCards: Fanconi Anemia, Complementation Group B, also known as fanconi anemia, is related to fanconi anemia, complementation group a and pancreatic cancer. An important gene associated with Fanconi Anemia, Complementation Group B is FANCB (Fanconi anemia, complementation group B), and among its related pathways are DNA damage ATM/ATR regulation of G1/S checkpoint and Formation of RNA Pol II elongation complex . The compounds melphalan and cisplatin have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and endocrine/exocrine gland.

OMIM:

Aliases & Classifications for Fanconi Anemia, Complementation Group B

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56UMLS, 43OMIM
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fanconi anemia, complementation group b 43
fanconi anemia 56



Related Diseases for Fanconi Anemia, Complementation Group B

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16GeneCards, 17GeneDecks
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Diseases related to fanconi anemia, complementation group b via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1fanconi anemia, complementation group a34.2FANCA
2pancreatic cancer30.5FANCC, FANCG
3leukemia30.0FANCD2, FANCF, FANCC, FANCB
4breast cancer29.1FANCG, FANCC, FANCE, FANCF, FANCL, FANCD2
5ovarian cancer29.1FANCD2, FANCF
6squamous cell carcinoma28.5FANCA, FANCD2, FANCC, FANCG
7nijmegen breakage syndrome28.4FANCD2
8fanconi's anemia26.8FANCB, FANCG, FANCC, FANCE, FANCF, FANCL
9anemia26.7FANCB, FANCG, FANCC, FANCE, FANCF, FANCL
10acute lymphocytic leukemia12.4FANCA, FANCG
11aplastic anemia10.4FANCC, FANCE, FANCF, FANCL, FANCD2, FANCA
12squamous cell carcinoma of the head and neck10.0FANCG, FANCC, FANCE, FANCF, FANCL, FANCD2
13fanconi anemia, complementation group j8.0
14fanconi anemia, complementation group i8.0
15bloom syndrome7.6
16myeloid leukemia7.6
17pancreatitis7.6
18brca2-related fanconi anemia7.6
19brip1-related fanconi anemia7.6
20fanca-related fanconi anemia7.6
21fancb-related fanconi anemia7.6
22fancc-related fanconi anemia7.6
23fancd2-related fanconi anemia7.6
24fance-related fanconi anemia7.6
25fancf-related fanconi anemia7.6
26fancg-related fanconi anemia7.6
27fanci-related fanconi anemia7.6
28fancl-related fanconi anemia7.6
29fancm-related fanconi anemia7.6
30palb2-related fanconi anemia7.6
31rad51c-related fanconi anemia7.6
32slx4-related fanconi anemia7.6
33fanconi anemia, complementation group d17.6
34breast cancer susceptibility7.6
35fanconi anemia, complementation group n7.6
36fanconi anemia, complementation group 07.6
37acute myeloid leukemia7.1
38friedreich ataxia7.1
39fanconi syndrome7.1
40familial breast cancer7.1
41alcoholism7.1
42ataxia telangiectasia6.2
43pancytopenia6.2
44chronic myeloid leukemia6.2
45basal cell carcinoma6.2
46cervical cancer6.2
47cervicitis6.2
48hepatocellular carcinoma6.2
49lymphoblastic leukemia6.2
50melanoma6.2

Graphical network of the top 20 diseases related to fanconi anemia, complementation group b:



Diseases related to fanconi anemia, complementation group b

Symptoms for Fanconi Anemia, Complementation Group B

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43OMIM
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Clinical features from OMIM:

Drugs & Therapeutics for Fanconi Anemia, Complementation Group B

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5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for fanconi anemia, complementation group b

Drug clinical trials:

Search ClinicalTrials for fanconi anemia, complementation group b

Search NIH Clinical Center for fanconi anemia, complementation group b

Search CenterWatch for fanconi anemia, complementation group b

Genetic Tests for Fanconi Anemia, Complementation Group B

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Anatomical Context for Fanconi Anemia, Complementation Group B

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Animal Models for Fanconi Anemia, Complementation Group B or affiliated genes

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33MGI, 26inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to fanconi anemia, complementation group b:

33
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
reproductive system phenotype
MP:00053897.6FANCG, FANCC, FANCL, FANCD2, FANCA
2
endocrine/exocrine gland phenotype
MP:00053797.3FANCG, FANCC, FANCL, FANCD2, FANCA

Publications for Fanconi Anemia, Complementation Group B

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47PubMed
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Articles related to fanconi anemia, complementation group b:

idTitleAuthorsYearAffiliating Genes
1X-linked inheritance of Fanconi anemia complementation group B. (15502827)Meetei A.R.... Joenje H.2004FANCL, FANCC, FANCA

Variations for Fanconi Anemia, Complementation Group B

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Expression for genes affiliated with Fanconi Anemia, Complementation Group B

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Fanconi Anemia, Complementation Group B

Pathways for genes affiliated with Fanconi Anemia, Complementation Group B

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12EMD Millipore, 50Reactome, 48QIAGEN, 27KEGG, 34NCBI BioSystems Database
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Pathways related to fanconi anemia, complementation group b according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
DNA damage ATM/ATR regulation of G1/S checkpoint12
9.1FANCL, FANCD2
2
Formation of RNA Pol II elongation complex 50
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9.1FANCL, FANCD2
3
Meiosis12
8.4FANCD2, FANCL, FANCG, FANCB
4
Chks in Checkpoint Regulation48
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7.3FANCG, FANCC, FANCE, FANCF, FANCD2, FANCA
5
BRCA1 Pathway48
6.7FANCG, FANCC, FANCE, FANCF, FANCL, FANCD2
6
Nucleotide excision repair27
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6.4FANCB, FANCG, FANCA, FANCD2, FANCL, FANCF
7
Fanconi Anemia pathway50
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6.4FANCB, FANCL, FANCD2, FANCA, FANCF, FANCG

Compounds for genes affiliated with Fanconi Anemia, Complementation Group B

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41Novoseek, 11DrugBank, 46PharmGKB
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Compounds related to fanconi anemia, complementation group b according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1melphalan41 119.8FANCD2, FANCC
2cisplatin41 46 1110.6FANCG, FANCD2, FANCA
3diepoxybutane418.0FANCD2, FANCC, FANCA, FANCG
4mitomycin c416.7FANCC, FANCE, FANCF, FANCL, FANCD2, FANCA

GO Terms for genes affiliated with Fanconi Anemia, Complementation Group B

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15Gene Ontology
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Cellular components related to fanconi anemia, complementation group b according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Fanconi anaemia nuclear complexGO:0432406.9FANCB, FANCG, FANCC, FANCE, FANCF, FANCL
2nucleoplasmGO:0056546.4FANCB, FANCG, FANCC, FANCE, FANCF, FANCL

Biological processes related to fanconi anemia, complementation group b according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complex assemblyGO:0064619.3FANCA, FANCC
2regulation of cell proliferationGO:0421279.0FANCA, FANCL
3gamete generationGO:0072769.0FANCD2, FANCL
4DNA repairGO:0062816.4FANCA, FANCB, FANCG, FANCC, FANCE, FANCF

Products for genes affiliated with Fanconi Anemia, Complementation Group B

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  • Antibodies
  • Proteins
  • Lysates

Sources for Fanconi Anemia, Complementation Group B

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3CDC
13ExPASy
14FMA
21HGMD
22HMDB
23ICD10
24ICD10 via Orphanet
25ICD9CM
27KEGG
31MeSH
32MESH via Orphanet
33MGI
36NCIt
37NDF-RT
40NINDS
41Novoseek
43OMIM
44OMIM via Orphanet
47PubMed
48QIAGEN
53SNOMED-CT via Orphanet
56UMLS
57UMLS via Orphanet
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