MCID: FNC032
MIFTS: 24

Fanconi Anemia, Complementation Group B malady

Summaries for Fanconi Anemia, Complementation Group B

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46OMIM, 32MalaCards
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MalaCards: Fanconi Anemia, Complementation Group B is related to nijmegen breakage syndrome and pancreatic cancer. An important gene associated with Fanconi Anemia, Complementation Group B is FANCB (Fanconi anemia, complementation group B), and among its related pathways are DNA damage ATM/ATR regulation of G1/S checkpoint and DNA damage Role of Brca1 and Brca2 in DNA repair. The compounds melphalan and cisplatin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and bone, and related mouse phenotypes are endocrine/exocrine gland and cellular.

Description from OMIM:46 300514

Aliases & Classifications for Fanconi Anemia, Complementation Group B

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46OMIM
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Aliases & Descriptions:

fanconi anemia, complementation group b 46


Related Diseases for Fanconi Anemia, Complementation Group B

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17GeneCards, 18GeneDecks
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Diseases in the Fanconi Anemia, Complementation Group C family:

fanconi anemia, complementation group b

Diseases related to Fanconi Anemia, Complementation Group B via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1nijmegen breakage syndrome10.0FANCD2
2pancreatic cancer10.0FANCC, FANCG
3ovarian cancer10.0FANCF, FANCD2
4aplastic anemia10.0FANCL, FANCG
5precursor t-cell acute lymphoblastic leukemia10.0FANCA, FANCG
6leukemia10.0FANCC, FANCF, FANCD2, FANCB
7squamous cell carcinoma10.0FANCC, FANCD2, FANCG, FANCA
8deficiency anemia9.9FANCA, FANCC, FANCB, FANCD2, FANCG, FANCF
9squamous cell carcinoma of the head and neck9.9FANCE, FANCF, FANCG, FANCD2, FANCA, FANCL
10breast cancer9.9FANCA, FANCL, FANCG, FANCD2, FANCF, FANCC
11fanconi's anemia9.9FANCF, FANCD2, FANCB, FANCG, FANCC, FANCE

Graphical network of diseases related to Fanconi Anemia, Complementation Group B:



Diseases related to fanconi anemia, complementation group b

Clinical Features for Fanconi Anemia, Complementation Group B

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46OMIM
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Clinical features from OMIM:

300514

Drugs & Therapeutics for Fanconi Anemia, Complementation Group B

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Fanconi Anemia, Complementation Group B

Drug clinical trials:

Search ClinicalTrials for Fanconi Anemia, Complementation Group B

Search NIH Clinical Center for Fanconi Anemia, Complementation Group B

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Genetic Tests for Fanconi Anemia, Complementation Group B

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Anatomical Context for Fanconi Anemia, Complementation Group B

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32MalaCards
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MalaCards organs/tissues related to Fanconi Anemia, Complementation Group B:

32
Bone marrow, Bone

Animal Models for Fanconi Anemia, Complementation Group B or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Fanconi Anemia, Complementation Group B:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.7FANCD2, FANCL, FANCC
2MP:00053847.6FANCA, FANCC, FANCD2, FANCG, FANCL
3MP:00053897.3FANCC, FANCD2, FANCG, FANCL, FANCA

Publications for Fanconi Anemia, Complementation Group B

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Genetic Variations for Fanconi Anemia, Complementation Group B

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Expression for genes affiliated with Fanconi Anemia, Complementation Group B

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fanconi Anemia, Complementation Group B

Search GEO for disease gene expression data for Fanconi Anemia, Complementation Group B.

Pathways for genes affiliated with Fanconi Anemia, Complementation Group B

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12EMD Millipore, 51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Fanconi Anemia, Complementation Group B according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3FANCL, FANCD2
2
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.3FANCD2, FANCL
38.6FANCD2, FANCL, FANCG, FANCB
4
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7.3FANCD2, FANCA, FANCC, FANCG, FANCF, FANCE
56.7FANCA, FANCC, FANCD2, FANCG, FANCL, FANCF
6
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6.4FANCA, FANCF, FANCL, FANCE, FANCG, FANCD2
76.4FANCL, FANCE, FANCF, FANCG, FANCD2, FANCB
8
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6.4FANCL, FANCA, FANCC, FANCB, FANCD2, FANCG

Compounds for genes affiliated with Fanconi Anemia, Complementation Group B

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44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Fanconi Anemia, Complementation Group B according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1melphalan44 1110.0FANCD2, FANCC
2cisplatin44 49 59 1111.6FANCA, FANCD2, FANCG
3diepoxybutane448.0FANCD2, FANCC, FANCG, FANCA
4mitomycin c446.7FANCC, FANCD2, FANCG, FANCF, FANCE, FANCL

GO Terms for genes affiliated with Fanconi Anemia, Complementation Group B

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16Gene Ontology
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Cellular components related to Fanconi Anemia, Complementation Group B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Fanconi anaemia nuclear complexGO:0432406.7FANCA, FANCC, FANCB, FANCG, FANCF, FANCE
2nucleoplasmGO:0056546.4FANCA, FANCC, FANCB, FANCD2, FANCG, FANCF

Biological processes related to Fanconi Anemia, Complementation Group B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gamete generationGO:0072769.2FANCL, FANCD2
2protein complex assemblyGO:0064619.1FANCC, FANCA
3regulation of cell proliferationGO:0421278.8FANCL, FANCA
4DNA repairGO:0062816.4FANCL, FANCA, FANCC, FANCB, FANCD2, FANCG

Molecular functions related to Fanconi Anemia, Complementation Group B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.9FANCE, FANCF, FANCG, FANCD2, FANCB, FANCC

Products for genes affiliated with Fanconi Anemia, Complementation Group B

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  • Antibodies
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Sources for Fanconi Anemia, Complementation Group B

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet