MCID: FNC032
MIFTS: 29

Fanconi Anemia, Complementation Group B malady

Nephrological diseases, Bone diseases, Skin diseases, Fetal diseases, Blood diseases, Cancer diseases, Rare diseases categories

Summaries for Fanconi Anemia, Complementation Group B

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48OMIM, 34MalaCards
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MalaCards: Fanconi Anemia, Complementation Group B is related to aplastic anemia and precursor t-cell acute lymphoblastic leukemia. An important gene associated with Fanconi Anemia, Complementation Group B is FANCB (Fanconi anemia, complementation group B), and among its related pathways are DNA damage Role of Brca1 and Brca2 in DNA repair and DNA damage ATM ATR regulation of G1 S checkpoint. The compounds melphalan and cisplatin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and bone, and related mouse phenotypes are cellular and endocrine/exocrine gland.

Description from OMIM:48 300514

Aliases & Classifications for Fanconi Anemia, Complementation Group B

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48OMIM
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Classifications:



Aliases & Descriptions:

fanconi anemia, complementation group b 48


Related Diseases for Fanconi Anemia, Complementation Group B

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18GeneCards, 19GeneDecks
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Diseases in the Fanconi Anemia, Complementation Group C family:

fanconi anemia, complementation group b

Diseases related to Fanconi Anemia, Complementation Group B via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1aplastic anemia10.0FANCL, FANCG
2precursor t-cell acute lymphoblastic leukemia10.0FANCA, FANCG
3ataxia telangiectasia10.0FANCD2, FANCC
4leukemia9.9FANCD2, FANCF, FANCC, FANCB
5tongue squamous cell carcinoma9.9FANCC, FANCD2, FANCG, FANCA
6deficiency anemia9.8FANCB, FANCC, FANCF, FANCD2, FANCE, FANCG
7squamous cell carcinoma of the head and neck9.7FANCC, FANCF, FANCD2, FANCE, FANCG, FANCL
8breast cancer9.7FANCC, FANCF, FANCD2, FANCE, FANCG, FANCL
9fanconi's anemia9.7FANCB, FANCC, FANCF, FANCD2, FANCE, FANCG

Graphical network of diseases related to Fanconi Anemia, Complementation Group B:



Diseases related to fanconi anemia, complementation group b

Symptoms for Fanconi Anemia, Complementation Group B

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48OMIM
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Clinical features from OMIM:

300514

Drugs & Therapeutics for Fanconi Anemia, Complementation Group B

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Fanconi Anemia, Complementation Group B

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Anatomical Context for Fanconi Anemia, Complementation Group B

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34MalaCards
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MalaCards organs/tissues related to Fanconi Anemia, Complementation Group B:

34
Bone marrow, Bone

Animal Models for Fanconi Anemia, Complementation Group B or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Fanconi Anemia, Complementation Group B:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.6FANCA, FANCL, FANCG, FANCD2, FANCC
2MP:00053797.5FANCA, FANCL, FANCG, FANCD2, FANCC
3MP:00053897.3FANCC, FANCD2, FANCG, FANCL, FANCA

Publications for Fanconi Anemia, Complementation Group B

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53PubMed
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Articles related to Fanconi Anemia, Complementation Group B:

idTitleAuthorsYear
1
X-linked inheritance of Fanconi anemia complementation group B. (15502827)
2004

Variations for Fanconi Anemia, Complementation Group B

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1 National Center for Biotechnology Information (Clinvar)
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Expression for genes affiliated with Fanconi Anemia, Complementation Group B

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fanconi Anemia, Complementation Group B

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Pathways for genes affiliated with Fanconi Anemia, Complementation Group B

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51PathCards, 61Thomson Reuters, 13EMD Millipore, 54QIAGEN, 39NCBI BioSystems Database, 31KEGG, 56Reactome
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Compounds for genes affiliated with Fanconi Anemia, Complementation Group B

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46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience
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Compounds related to Fanconi Anemia, Complementation Group B according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1melphalan46 52 1211.3FANCD2, FANCC
2cisplatin46 52 62 1211.3FANCA, FANCG, FANCD2
3diepoxybutane468.0FANCC, FANCD2, FANCG, FANCA
4mitomycin c466.7FANCA, FANCL, FANCG, FANCE, FANCD2, FANCF

GO Terms for genes affiliated with Fanconi Anemia, Complementation Group B

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17Gene Ontology
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Cellular components related to Fanconi Anemia, Complementation Group B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Fanconi anaemia nuclear complexGO:0432406.7FANCA, FANCB, FANCC, FANCF, FANCE, FANCG
2nucleoplasmGO:0056546.4FANCC, FANCF, FANCD2, FANCE, FANCG, FANCL

Biological processes related to Fanconi Anemia, Complementation Group B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gamete generationGO:0072769.2FANCL, FANCD2
2protein complex assemblyGO:0064619.1FANCA, FANCC
3regulation of cell proliferationGO:0421278.8FANCA, FANCL
4DNA repairGO:0062816.4FANCA, FANCB, FANCC, FANCF, FANCD2, FANCE

Molecular functions related to Fanconi Anemia, Complementation Group B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.4FANCA, FANCG, FANCD2, FANCF, FANCC, FANCB

Products for genes affiliated with Fanconi Anemia, Complementation Group B

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  • Antibodies
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Sources for Fanconi Anemia, Complementation Group B

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet