Fanconi Anemia, Complementation Group B disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Fanconi Anemia, Complementation Group B

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⁴⁶OMIM, ³²MalaCards
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MalaCards: Fanconi Anemia, Complementation Group B is related to nijmegen breakage syndrome and pancreatic cancer. An important gene associated with Fanconi Anemia, Complementation Group B is FANCB (Fanconi anemia, complementation group B), and among its related pathways are DNA damage ATM/ATR regulation of G1/S checkpoint and DNA damage Role of Brca1 and Brca2 in DNA repair. The compounds melphalan and cisplatin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and bone, and related mouse phenotypes are endocrine/exocrine gland and cellular.

Description from OMIM:⁴⁶ 300514

Aliases & Classifications for Fanconi Anemia, Complementation Group B

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⁴⁶OMIM
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Aliases & Descriptions:

fanconi anemia, complementation group b ⁴⁶

Related Diseases for Fanconi Anemia, Complementation Group B

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
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Diseases in the Fanconi Anemia, Complementation Group C family:

fanconi anemia, complementation group b

Diseases related to Fanconi Anemia, Complementation Group B via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)

id	Related Disease	Score	Top Affiliating Genes
1	nijmegen breakage syndrome	10.0	FANCD2
2	pancreatic cancer	10.0	FANCC, FANCG
3	ovarian cancer	10.0	FANCF, FANCD2
4	aplastic anemia	10.0	FANCL, FANCG
5	precursor t-cell acute lymphoblastic leukemia	10.0	FANCA, FANCG
6	leukemia	10.0	FANCC, FANCF, FANCD2, FANCB
7	squamous cell carcinoma	10.0	FANCC, FANCD2, FANCG, FANCA
8	deficiency anemia	9.9	FANCA, FANCC, FANCB, FANCD2, FANCG, FANCF
9	squamous cell carcinoma of the head and neck	9.9	FANCE, FANCF, FANCG, FANCD2, FANCA, FANCL
10	breast cancer	9.9	FANCA, FANCL, FANCG, FANCD2, FANCF, FANCC
11	fanconi's anemia	9.9	FANCF, FANCD2, FANCB, FANCG, FANCC, FANCE

Graphical network of diseases related to Fanconi Anemia, Complementation Group B:

Clinical Features for Fanconi Anemia, Complementation Group B

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⁴⁶OMIM
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Clinical features from OMIM:

300514

Drugs & Therapeutics for Fanconi Anemia, Complementation Group B

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Approved drugs:

Search CenterWatch for Fanconi Anemia, Complementation Group B

Drug clinical trials:

Search ClinicalTrials for Fanconi Anemia, Complementation Group B

Search NIH Clinical Center for Fanconi Anemia, Complementation Group B

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Genetic Tests for Fanconi Anemia, Complementation Group B

Anatomical Context for Fanconi Anemia, Complementation Group B

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³²MalaCards
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MalaCards organs/tissues related to Fanconi Anemia, Complementation Group B:

³²

Bone marrow, Bone

Animal Models for Fanconi Anemia, Complementation Group B or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Fanconi Anemia, Complementation Group B:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	8.7	FANCD2, FANCL, FANCC
2	cellular phenotype	MP:0005384	7.6	FANCA, FANCC, FANCD2, FANCG, FANCL
3	reproductive system phenotype	MP:0005389	7.3	FANCC, FANCD2, FANCG, FANCL, FANCA

Publications for Fanconi Anemia, Complementation Group B

Genes related to Fanconi Anemia, Complementation Group B

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc., ⁴⁶OMIM
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Genes related to Fanconi Anemia, Complementation Group B:

id	Symbol	Description	Score	Implication
1	FANCB	Fanconi anemia, complementation group B	21.59	Molecular basis known ⁴⁶ GeneCards inferred : Proteins, Orthologs, Domains & Families, Publications, Disorders, Gene name (show sections)
2	FANCF	Fanconi anemia, complementation group F	18.86	GeneCards inferred : Publications, Disorders (show sections)
3	FANCG	Fanconi anemia, complementation group G	16.36	GeneCards inferred : Publications, Disorders (show sections)
4	FANCE	Fanconi anemia, complementation group E	13.86	GeneCards inferred : Publications, Disorders (show sections)
5	FANCL	Fanconi anemia, complementation group L	11.36	GeneCards inferred : Publications, Disorders (show sections)
6	FANCD2	Fanconi anemia, complementation group D2	8.86	GeneCards inferred : Publications, Disorders (show sections)
7	FANCA	Fanconi anemia, complementation group A	6.36	GeneCards inferred : Publications, Disorders (show sections)
8	FANCC	Fanconi anemia, complementation group C	3.86	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Fanconi Anemia, Complementation Group B disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	7	7	8
2	LSBio	-	-	8

Genetic Variations for Fanconi Anemia, Complementation Group B

Expression for genes affiliated with Fanconi Anemia, Complementation Group B

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fanconi Anemia, Complementation Group B

Search GEO for disease gene expression data for Fanconi Anemia, Complementation Group B.

Pathways for genes affiliated with Fanconi Anemia, Complementation Group B

Sources:
¹²EMD Millipore, ⁵¹QIAGEN, ⁵³Reactome, ³⁷NCBI BioSystems Database, ²⁹KEGG
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Pathways related to Fanconi Anemia, Complementation Group B according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	DNA damage ATM/ATR regulation of G1/S checkpoint¹²	9.3	FANCL, FANCD2
2	DNA damage Role of Brca1 and Brca2 in DNA repair Hide members DNA damage Role of Brca1 and Brca2 in DNA repair¹²	9.3	FANCD2, FANCL
3	Meiosis¹²	8.6	FANCD2, FANCL, FANCG, FANCB
4	Chks in Checkpoint Regulation⁵¹ Hide members DNA Repair Mechanisms⁵¹	7.3	FANCD2, FANCA, FANCC, FANCG, FANCF, FANCE
5	BRCA1 Pathway⁵¹	6.7	FANCA, FANCC, FANCD2, FANCG, FANCL, FANCF
6	Fanconi Anemia pathway⁵³ Hide members BARD1 signaling events³⁷ Fanconis Anaemia Pathway⁵¹ Regulation of the Fanconi anemia pathway⁵³	6.4	FANCA, FANCF, FANCL, FANCE, FANCG, FANCD2
7	Fanconi anemia pathway²⁹	6.4	FANCL, FANCE, FANCF, FANCG, FANCD2, FANCB
8	Nucleotide Excision Repair⁵³ Hide members DNA Repair⁵³	6.4	FANCL, FANCA, FANCC, FANCB, FANCD2, FANCG

Compounds for genes affiliated with Fanconi Anemia, Complementation Group B

Sources:
⁴⁴Novoseek, ¹¹DrugBank, ⁴⁹PharmGKB, ⁵⁹Tocris Bioscience
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Compounds related to Fanconi Anemia, Complementation Group B according to GeneCards/GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	melphalan⁴⁴ ¹¹	10.0	FANCD2, FANCC
2	cisplatin⁴⁴ ⁴⁹ ⁵⁹ ¹¹	11.6	FANCA, FANCD2, FANCG
3	diepoxybutane⁴⁴	8.0	FANCD2, FANCC, FANCG, FANCA
4	mitomycin c⁴⁴	6.7	FANCC, FANCD2, FANCG, FANCF, FANCE, FANCL

GO Terms for genes affiliated with Fanconi Anemia, Complementation Group B

Sources:
¹⁶Gene Ontology
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Cellular components related to Fanconi Anemia, Complementation Group B according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Fanconi anaemia nuclear complex	GO:043240	6.7	FANCA, FANCC, FANCB, FANCG, FANCF, FANCE
2	nucleoplasm	GO:005654	6.4	FANCA, FANCC, FANCB, FANCD2, FANCG, FANCF

Biological processes related to Fanconi Anemia, Complementation Group B according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	gamete generation	GO:007276	9.2	FANCL, FANCD2
2	protein complex assembly	GO:006461	9.1	FANCC, FANCA
3	regulation of cell proliferation	GO:042127	8.8	FANCL, FANCA
4	DNA repair	GO:006281	6.4	FANCL, FANCA, FANCC, FANCB, FANCD2, FANCG