MCID: FNC031
MIFTS: 25

Fanconi Anemia, Complementation Group M malady

Summaries for Fanconi Anemia, Complementation Group M

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46OMIM, 32MalaCards
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MalaCards: Fanconi Anemia, Complementation Group M is related to pancreatic cancer and rothmund-thomson syndrome. An important gene associated with Fanconi Anemia, Complementation Group M is FANCM (Fanconi anemia, complementation group M), and among its related pathways are DNA damage Role of Brca1 and Brca2 in DNA repair and Homologous recombination. The compounds melphalan and methylmethanesulfonate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and bone, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Description from OMIM:46 614087

Aliases & Classifications for Fanconi Anemia, Complementation Group M

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46OMIM
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Aliases & Descriptions:

fanconi anemia, complementation group m 46


Related Diseases for Fanconi Anemia, Complementation Group M

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Fanconi Anemia, Complementation Group M:



Diseases related to fanconi anemia, complementation group m

Clinical Features for Fanconi Anemia, Complementation Group M

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46OMIM
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Clinical features from OMIM:

614087

Drugs & Therapeutics for Fanconi Anemia, Complementation Group M

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Fanconi Anemia, Complementation Group M

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Anatomical Context for Fanconi Anemia, Complementation Group M

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32MalaCards
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MalaCards organs/tissues related to Fanconi Anemia, Complementation Group M:

32
Bone marrow, Bone

Animal Models for Fanconi Anemia, Complementation Group M or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Fanconi Anemia, Complementation Group M:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9BLM, FANCM, FANCD2, FANCA
2MP:00053798.7FANCC, FANCD2, FANCL, FANCM
3MP:00053897.7FANCA, FANCC, FANCD2, FANCG, FANCL, FANCM
4MP:00053847.0BLM, FANCA, FANCC, FANCD2, FANCG, FANCL

Publications for Fanconi Anemia, Complementation Group M

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Genetic Variations for Fanconi Anemia, Complementation Group M

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Expression for genes affiliated with Fanconi Anemia, Complementation Group M

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fanconi Anemia, Complementation Group M

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Pathways for genes affiliated with Fanconi Anemia, Complementation Group M

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12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 53Reactome
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Pathways related to Fanconi Anemia, Complementation Group M according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.6FANCL, FANCD2
2
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9.4BLM, TOP3A
39.1FANCD2, FANCL, BLM
4
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8.1FANCA, FANCC, FANCD2, FANCG, FANCF, FANCE
58.0FANCB, FANCD2, FANCG, FANCL, TOP3A, BLM
67.1FANCA, BLM, FANCL, FANCE, FANCF, FANCG
7
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7.1FANCM, FANCL, FANCE, FANCF, FANCG, FANCD2
8
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7.1FANCA, FANCC, FANCB, FANCD2, FANCG, FANCF
95.2FANCD2, FANCG, FANCF, FANCE, FANCL, FANCM

Compounds for genes affiliated with Fanconi Anemia, Complementation Group M

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44Novoseek, 11DrugBank, 49PharmGKB
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Compounds related to Fanconi Anemia, Complementation Group M according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1melphalan44 1110.5FANCD2, FANCC
2methylmethanesulfonate449.1BLM, TOP3A
3hydroxyurea44 49 1111.0BLM, TOP3A, FANCD2
4diepoxybutane448.8FANCA, FANCC, FANCD2, FANCG
5mitomycin c447.7FANCL, FANCE, FANCF, FANCG, FANCD2, FANCC

GO Terms for genes affiliated with Fanconi Anemia, Complementation Group M

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16Gene Ontology
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Cellular components related to Fanconi Anemia, Complementation Group M according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Fanconi anaemia nuclear complexGO:0432407.2FANCA, FANCC, FANCB, FANCG, FANCF, FANCE
2nucleoplasmGO:0056546.3C17orf70, FANCA, FANCC, FANCB, FANCD2, FANCG

Biological processes related to Fanconi Anemia, Complementation Group M according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gamete generationGO:0072769.6FANCL, FANCD2
2replication fork processingGO:0312979.4BLM, FANCM
3DNA repairGO:0062815.7BLM, C17orf70, FANCA, FANCC, FANCB, FANCD2

Molecular functions related to Fanconi Anemia, Complementation Group M according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP-dependent helicase activityGO:0080269.7BLM, FANCM
2protein bindingGO:0055155.4BLM, C17orf70, FANCA, FANCC, FANCB, FANCD2

Products for genes affiliated with Fanconi Anemia, Complementation Group M

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  • Antibodies
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  • Antibodies

Sources for Fanconi Anemia, Complementation Group M

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet