MCID: FNC031
MIFTS: 28

Fanconi Anemia, Complementation Group M malady

Summaries for Fanconi Anemia, Complementation Group M

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47OMIM, 33MalaCards
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MalaCards: Fanconi Anemia, Complementation Group M is related to fanconi anemia, complementation group g and fanconi anemia, complementation group c. An important gene associated with Fanconi Anemia, Complementation Group M is FANCM (Fanconi anemia, complementation group M), and among its related pathways are DNA damage Role of Brca1 and Brca2 in DNA repair and Homologous recombination. The compounds melphalan and methylmethanesulfonate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and breast, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Description from OMIM:47 614087

Aliases & Classifications for Fanconi Anemia, Complementation Group M

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47OMIM
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Aliases & Descriptions:

fanconi anemia, complementation group m 47


Related Diseases for Fanconi Anemia, Complementation Group M

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Fanconi Anemia, Complementation Group M:



Diseases related to fanconi anemia, complementation group m

Clinical Features for Fanconi Anemia, Complementation Group M

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47OMIM
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Clinical features from OMIM:

614087

Drugs & Therapeutics for Fanconi Anemia, Complementation Group M

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Fanconi Anemia, Complementation Group M

Anatomical Context for Fanconi Anemia, Complementation Group M

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33MalaCards
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MalaCards organs/tissues related to Fanconi Anemia, Complementation Group M:

33
Bone marrow, Breast

Animal Models for Fanconi Anemia, Complementation Group M or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Fanconi Anemia, Complementation Group M:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9FANCA, FANCD2, FANCM, BLM
2MP:00053798.7FANCC, FANCD2, FANCL, FANCM
3MP:00053897.7FANCC, FANCD2, FANCG, FANCL, FANCM, FANCA
4MP:00053847.0BLM, FANCA, FANCC, FANCD2, FANCG, FANCL

Publications for Fanconi Anemia, Complementation Group M

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51PubMed
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Articles related to Fanconi Anemia, Complementation Group M:

(show all 12)
idTitleAuthorsYear
1
Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein. (24170812)
2013
2
Silencing of fanconi anemia complementation group f exhibits potent chemosensitization of mitomycin C activity in breast cancer cells. (24155758)
2013
3
Identification and characterization of mutations in FANCL gene: a second case of Fanconi anemia belonging to FA-L complementation group. (19405097)
2009
4
Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M. (19423727)
2009
5
Validation of Fanconi anemia complementation Group A assignment using molecular analysis. (19367192)
2009
6
Germ line Fanconi anemia complementation group C mutations and pancreatic cancer. (15695377)
2005
7
The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality. (11520787)
2001
8
Role of double-stranded RNA-dependent protein kinase in mediating hypersensitivity of Fanconi anemia complementation group C cells to interferon gamma, tumor necrosis factor-alpha, and double-stranded RNA. (11238103)
2001
9
Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group. (11110674)
2000
10
SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein. (10600472)
1999
11
Mutagenic response of Fanconi's anemia cells from a defined complementation group after treatment with photoactivated bifunctional psoralens. (2159378)
1990
12
The fate of 8-methoxypsoralen-photoinduced DNA interstrand crosslinks in Fanconi's anemia cells of defined genetic complementation groups. (3670329)
1987

Genetic Variations for Fanconi Anemia, Complementation Group M

Expression for genes affiliated with Fanconi Anemia, Complementation Group M

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fanconi Anemia, Complementation Group M

Search GEO for disease gene expression data for Fanconi Anemia, Complementation Group M.

Pathways for genes affiliated with Fanconi Anemia, Complementation Group M

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 54Reactome
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Pathways related to Fanconi Anemia, Complementation Group M according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.6FANCL, FANCD2
2
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9.4TOP3A, BLM
39.1BLM, FANCL, FANCD2
4
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8.1FANCE, FANCF, FANCG, FANCD2, FANCC, FANCA
58.0FANCB, FANCD2, FANCG, BLM, TOP3A, FANCL
67.1FANCA, FANCC, FANCF, FANCE, FANCL, BLM
7
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7.1FANCA, FANCC, FANCB, FANCD2, FANCG, FANCF
8
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7.1FANCA, FANCL, FANCC, FANCB, FANCD2, FANCG
95.2FANCD2, FANCG, FANCF, FANCE, FANCL, FANCM

Compounds for genes affiliated with Fanconi Anemia, Complementation Group M

Sources:
45Novoseek, 11DrugBank, 50PharmGKB
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Compounds related to Fanconi Anemia, Complementation Group M according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1melphalan45 1110.5FANCC, FANCD2
2methylmethanesulfonate459.1BLM, TOP3A
3hydroxyurea45 50 1111.0BLM, TOP3A, FANCD2
4diepoxybutane458.8FANCA, FANCC, FANCD2, FANCG
5mitomycin c457.7FANCL, FANCA, FANCC, FANCD2, FANCG, FANCF

GO Terms for genes affiliated with Fanconi Anemia, Complementation Group M

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16Gene Ontology
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Cellular components related to Fanconi Anemia, Complementation Group M according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Fanconi anaemia nuclear complexGO:0432407.2FANCA, FANCC, FANCB, FANCG, FANCF, FANCE
2nucleoplasmGO:0056546.3C17orf70, FANCA, FANCC, FANCB, FANCD2, FANCG

Biological processes related to Fanconi Anemia, Complementation Group M according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gamete generationGO:0072769.6FANCL, FANCD2
2replication fork processingGO:0312979.4BLM, FANCM
3DNA repairGO:0062815.7BLM, C17orf70, FANCA, FANCC, FANCB, FANCD2

Molecular functions related to Fanconi Anemia, Complementation Group M according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP-dependent helicase activityGO:0080269.7BLM, FANCM
2protein bindingGO:0055155.4BLM, C17orf70, FANCA, FANCC, FANCB, FANCD2

Products for genes affiliated with Fanconi Anemia, Complementation Group M

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  • Proteins
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  • Antibodies

Sources for Fanconi Anemia, Complementation Group M

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet