Fanconi Anemia, Complementation Group M malady

MalaCards: Fanconi Anemia, Complementation Group M, also known as fanconi anemia, is related to fanconi anemia, complementation group a and squamous cell carcinoma. An important gene associated with Fanconi Anemia, Complementation Group M is FANCM (Fanconi anemia, complementation group M), and among its related pathways are Meiotic Recombination and Homologous recombination. The compounds methylmethanesulfonate and hydroxyurea have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

fanconi anemia, complementation group m 33 fanconi anemia 43

Disease types for fanconi anemia, complementation group m family:

fanconi anemia, complementation group j	fanconi anemia, complementation group 0
fanconi anemia, complementation group n	fanconi anemia, complementation group a
fanconi anemia, complementation group l	fanconi anemia, complementation group i

Diseases related to fanconi anemia, complementation group m by text searches and GeneDecks gene sharing:

(show top 50)    (show all 77)

id	Related Disease	Score	Top Affiliating Genes
1	fanconi anemia, complementation group a	33.0	FANCG, FANCA
2	squamous cell carcinoma	28.7	FANCD2, FANCA, FANCC, FANCG
3	pancytopenia	27.6	FANCG, FANCC, FANCA
4	leukemia	27.4	TOP3A, FANCB, FANCG, FANCC, FANCF, FANCL
5	nijmegen breakage syndrome	27.1	FANCB, FANCF, FANCD2, BLM
6	breast cancer	27.0	TOP3A, FANCB, FANCM, FANCG, FANCC, FANCF
7	fanconi anemia, complementation group b	27.0	FANCD2, FANCA, FANCL, FANCE, FANCF, FANCC
8	carcinoma	26.7	FANCB, FANCM, FANCG, FANCC, FANCF, FANCE
9	fanconi's anemia	26.5	BLM, TOP3A, FANCD2, FANCA, FANCL, FANCE
10	anemia	26.5	FANCD2, FANCA, FANCL, FANCE, FANCF, FANCC
11	ovarian cancer	26.5	FANCG, FANCC, FANCF, FANCE, FANCA, FANCD2
12	bloom syndrome	26.5	FANCG, FANCM, TOP3A, FANCC, FANCF, BLM
13	ataxia telangiectasia	26.4	BLM, FANCD2, FANCC, TOP3A
14	pancreatic cancer	26.4	FANCM, FANCG, FANCC, FANCF, FANCE, FANCL
15	pancreatitis	26.3	FANCM, FANCG, FANCC, FANCF, FANCE, FANCL
16	skin cancer	26.1	FANCC, FANCL, FANCD2
17	oral squamous cell carcinoma	26.0	FANCG, FANCC, FANCA, FANCD2
18	breast cancer susceptibility	24.5	FANCA, FANCL, FANCE, FANCF, FANCC, FANCG
19	rothmund-thomson syndrome	12.8	BLM, TOP3A
20	mutagen sensitivity	12.7	BLM, FANCG
21	familial pancreatic cancer	12.3	FANCA, FANCC, FANCG
22	mayer-rokitansky-kuster-hauser syndrome	11.2	FANCC, FANCA, FANCD2, BLM
23	meningioma	11.1	BLM, FANCD2, FANCA, FANCL
24	hereditary breast ovarian cancer	10.8	FANCG, FANCC, FANCF, FANCE, FANCA, FANCD2
25	sporadic breast cancer	10.8	FANCG, FANCC, FANCF, FANCE, FANCA, FANCD2
26	epithelial ovarian cancer	10.8	FANCG, FANCC, FANCF, FANCE, FANCA, FANCD2
27	squamous cell carcinoma of the head and neck	10.3	FANCG, FANCC, FANCF, FANCE, FANCL, FANCA
28	leukopenia	10.3	FANCD2, FANCL, FANCE, FANCF, FANCC, FANCG
29	hereditary pancreatitis	10.1	FANCC, FANCG, FANCM, FANCF, FANCE, FANCD2
30	fanconi anemia, complementation group j	8.0
31	fanconi anemia, complementation group i	8.0
32	fance-related fanconi anemia	7.6
33	slx4-related fanconi anemia	7.6
34	fancf-related fanconi anemia	7.6
35	fancg-related fanconi anemia	7.6
36	fanci-related fanconi anemia	7.6
37	fancl-related fanconi anemia	7.6
38	fancm-related fanconi anemia	7.6
39	fanconi anemia, complementation group n	7.6
40	fanconi anemia, complementation group d1	7.6
41	fanconi anemia, complementation group l	7.6
42	fanconi anemia, complementation group g	7.6
43	brca2-related fanconi anemia	7.6
44	fanconi anemia, complementation group 0	7.6
45	brip1-related fanconi anemia	7.6
46	myeloid leukemia	7.6
47	fanca-related fanconi anemia	7.6
48	palb2-related fanconi anemia	7.6
49	fancb-related fanconi anemia	7.6
50	fancc-related fanconi anemia	7.6

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to fanconi anemia, complementation group m:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	tumorigenesis	MP:0002006	8.4	BLM, FANCD2, FANCA, FANCM
2	endocrine/exocrine gland phenotype	MP:0005379	7.3	FANCD2, FANCL, FANCC, FANCG, FANCM, FANCA
3	reproductive system phenotype	MP:0005389	7.1	FANCD2, FANCA, FANCL, FANCC, FANCG, FANCM
4	cellular phenotype	MP:0005384	6.5	BLM, FANCA, FANCD2, FANCL, FANCC, FANCG

Articles related to fanconi anemia, complementation group m:

id	Title	Authors	Year	Affiliating Genes
1	Impaired FANCD2 monoubiquitination and hypersensitivi ty to camptothecin uniquely characterize Fanconi anemia complementation group M . (19423727)	Singh T.R.... Meetei A.R.	2009	FANCA, FANCM, FANCD2
2	A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. (16116422)	Meetei A.R.... Wang W.	2005	BLM, FANCL, FANCC

Genes related to fanconi anemia, complementation group m according to GeneCards:

(show all 12)

id	Symbol	Description	Score	GeneCards Section Context
1	FANCM	Fanconi anemia, complementation group M	11.1	Publications, Aliases & Descriptions, Transcripts, Orthologs
2	C17orf70	chromosome 17 open reading frame 70	11.0	Publications
3	FANCE	Fanconi anemia, complementation group E	11.0	Publications
4	FANCF	Fanconi anemia, complementation group F	11.0	Publications
5	FANCG	Fanconi anemia, complementation group G	11.0	Publications
6	FANCB	Fanconi anemia, complementation group B	11.0	Publications
7	TOP3A	topoisomerase (DNA) III alpha	11.0	Publications
8	BLM	Bloom syndrome, RecQ helicase-like	11.0	Publications
9	FANCA	Fanconi anemia, complementation group A	11.0	Publications
10	FANCC	Fanconi anemia, complementation group C	11.0	Publications
11	FANCD2	Fanconi anemia, complementation group D2	11.0	Publications
12	FANCL	Fanconi anemia, complementation group L	11.0	Publications

Pathways related to fanconi anemia, complementation group m according to GeneDecks:

(show all 11)

id	Pathway	Score	Top Affiliating Genes
1	Meiotic Recombination38	9.6	TOP3A, BLM
2	Homologous recombination20	9.5	BLM, TOP3A
3	DNA damage_Role of Brca1 and Brca2 in DNA repair41	9.1	FANCL, FANCD2
4	DNA damage Role of Brca1 and Brca2 in DNA repair10	8.8	FANCD2, FANCL
5	DNA damage ATM/ATR regulation of G1/S checkpoint10	8.8	FANCL, BLM, FANCD2
6	DNA damage_ATM/ATR regulation of G1/S checkpoint41	8.7	BLM, FANCD2, FANCL
7	Meiosis10	7.7	FANCD2, FANCL, FANCG, FANCB, TOP3A, BLM
8	DNA Repair Mechanisms36	7.7	FANCA, FANCD2, FANCG, FANCE, FANCC, FANCF
9	Fanconis Anaemia Pathway36	7.3	FANCD2, FANCC, FANCF, FANCE, FANCL, FANCA
10	BRCA1 Pathway36	6.8	FANCL, BLM, FANCD2, FANCA, FANCE, FANCF
11	Fanconi Anemia pathway38	6.3	FANCD2, FANCA, FANCE, C17orf70, FANCB, FANCM

Compounds related to fanconi anemia, complementation group m according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	methylmethanesulfonate32	9.6	BLM, TOP3A
2	hydroxyurea32 9 9	10.5	TOP3A, FANCD2, BLM
3	diepoxybutane32	8.1	FANCA, FANCC, FANCD2, FANCG
4	mitomycin c32	7.0	FANCC, FANCF, FANCE, FANCL, FANCA, FANCD2

Cellular components related to fanconi anemia, complementation group m according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Fanconi anaemia nuclear complex	GO:043240	6.9	FANCB, FANCM, FANCG, FANCC, FANCF, FANCE
2	nucleoplasm	GO:005654	6.1	C17orf70, FANCB, FANCM, FANCG, FANCC, FANCF

Biological processes related to fanconi anemia, complementation group m according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	replication fork processing	GO:031297	9.8	BLM, FANCM
2	DNA repair	GO:006281	5.3	BLM, C17orf70, FANCB, FANCM, FANCG, FANCC

Molecular functions related to fanconi anemia, complementation group m according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	6.4	BLM, FANCD2, FANCA, FANCE, FANCF, FANCC