MCID: FRM003
MIFTS: 44

Farmer's Lung

Categories: Rare diseases, Respiratory diseases, Immune diseases

Aliases & Classifications for Farmer's Lung

MalaCards integrated aliases for Farmer's Lung:

Name: Farmer's Lung 12 50 42 14 69
Farmers Lung 12 52
Farmer's Lung Disease 56
Farmer Lung 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14453
ICD10 33 J67.0
ICD9CM 35 495.0
MeSH 42 D005203
NCIt 47 C34605
Orphanet 56 ORPHA99906
MESH via Orphanet 43 D005203
UMLS via Orphanet 70 C0015634
ICD10 via Orphanet 34 J67.0
UMLS 69 C0015634

Summaries for Farmer's Lung

Disease Ontology : 12 An extrinsic allergic alveolitis which is induced by the inhalation of spores (Aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. It is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

MalaCards based summary : Farmer's Lung, also known as farmers lung, is related to louse-borne relapsing fever and scirrhous adenocarcinoma. An important gene associated with Farmer's Lung is IL2 (Interleukin 2), and among its related pathways/superpathways are Innate Immune System and Developmental Biology. The drugs Abatacept and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and endothelial, and related phenotype is neoplasm.

Related Diseases for Farmer's Lung

Diseases related to Farmer's Lung via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
id Related Disease Score Top Affiliating Genes
1 louse-borne relapsing fever 10.6 IL2 PI3
2 scirrhous adenocarcinoma 10.6 IL2 TNF
3 autoimmune polyglandular syndrome type 3 10.5 IL2 TNF
4 spirillary rat-bite fever 10.5 IL2 TNF
5 amyotrophic lateral sclerosis type 10 10.5 IL2 TNF
6 tinea favosa 10.5 IL2 TNF
7 parametritis 10.5 IL2 TNF
8 cyclosporiasis 10.5 IL2 TNF
9 lung sarcoma 10.5 PI3 TNF
10 hemophagocytic lymphohistiocytosis 10.5 IL2 TNF
11 ceruminous carcinoma 10.5 IL2 TNF
12 acute monoblastic leukemia 10.5 IL2 TNF
13 hypospadias 10.5 IL2 TNF
14 endogenous depression 10.5 IL2 TNF
15 louping ill 10.4 IL2 TNF
16 orbital osteomyelitis 10.4 IL2 TNF
17 abnormal retinal correspondence 10.4 IL2 TNF
18 esophagus melanoma 10.4 IL2 TNF
19 left bundle branch hemiblock 10.4 IL2 TNF
20 labyrinthine bilateral reactive loss 10.3 ELANE IL2
21 erythema infectiosum 10.3 IL2 TNF
22 bullous pemphigoid 10.3 ELANE PI3
23 placenta praevia 10.3 ELANE PI3
24 gastric ulcer 10.3 IL2 TNF
25 juvenile dermatitis herpetiformis 10.3 ELANE PI3
26 intestinal disaccharidase deficiency 10.3 IL2 TNF
27 renal tubular acidosis 10.3 IL2 TNF
28 diastrophic dysplasia 10.3 ELANE PI3
29 chromoblastomycosis 10.3 ELANE TNF
30 mucocutaneous leishmaniasis 10.2 IL2 TNF
31 bardet-biedl syndrome 8 10.2 ELANE TNF
32 fallopian tube carcinoma 10.2 CD79A IL2
33 alcohol abuse 10.1 ELANE TNF
34 barbiturate dependence 10.1 CD79A IL2
35 gonadal disease 10.1 CD79A IL2
36 blue toe syndrome 10.1 IL2 TNF
37 neonatal period electroclinical syndrome 10.1 ELANE TNF
38 oropharyngeal cancer, childhood 10.1 CD79A TNF
39 uveitis 10.1 CD79A TNF
40 indolent myeloma 10.1 CD79A TNF
41 ileocolitis 10.1 CD79A TNF
42 dermatomycosis 10.0 CD79A TNF
43 discitis 10.0 CD79A TNF
44 central nervous system origin vertigo 10.0 CD79A IL2
45 hypogonadotropism 10.0 CD79A TNF
46 bladder diverticulum 10.0 CD79A TNF
47 acute vascular insufficiency of intestine 10.0 CD79A TNF
48 peripheral nervous system disease 10.0 CD79A TNF
49 testicular infarct 10.0 CD79A TNF
50 bartonellosis 10.0 CD79A TNF

Comorbidity relations with Farmer's Lung via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Farmer's Lung:



Diseases related to Farmer's Lung

Symptoms & Phenotypes for Farmer's Lung

MGI Mouse Phenotypes related to Farmer's Lung:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 CD79A ELANE IL2 TNF

Drugs & Therapeutics for Farmer's Lung

Drugs for Farmer's Lung (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 1, Phase 2 332348-12-6 10237
2
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
3
Capecitabine Approved, Investigational Phase 1, Phase 2 154361-50-9 60953
4
Cisplatin Approved Phase 1, Phase 2 15663-27-1 84093 441203 2767
5
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
6
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
7
Fulvestrant Approved, Investigational Phase 1, Phase 2 129453-61-8 104741 17756771
8
nivolumab Approved Phase 1, Phase 2 946414-94-4
9
Oxaliplatin Approved, Investigational Phase 1, Phase 2 61825-94-3 5310940 9887054 43805 6857599
10
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
11
Glutamic Acid Approved, Nutraceutical Phase 1, Phase 2 56-86-0 33032
12
leucovorin Approved, Nutraceutical Phase 1, Phase 2 58-05-9 143 6006
13 Antirheumatic Agents Phase 1, Phase 2
14 Immunosuppressive Agents Phase 1, Phase 2
15 Antimetabolites Phase 1, Phase 2
16 Albumin-Bound Paclitaxel Phase 1, Phase 2
17 Alkylating Agents Phase 1, Phase 2
18 Angiogenesis Inhibitors Phase 1, Phase 2
19 Angiogenesis Modulating Agents Phase 1, Phase 2
20 Antibodies Phase 1, Phase 2
21 Antibodies, Monoclonal Phase 1, Phase 2
22 Antimetabolites, Antineoplastic Phase 1, Phase 2
23 Antimitotic Agents Phase 1, Phase 2
24 Antineoplastic Agents, Hormonal Phase 1, Phase 2
25 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
26 Calcium, Dietary Phase 1, Phase 2
27 Endothelial Growth Factors Phase 1, Phase 2
28 Estrogen Antagonists Phase 1, Phase 2
29 Estrogen Receptor Antagonists Phase 1, Phase 2
30 Estrogens Phase 1, Phase 2
31 Hormone Antagonists Phase 1, Phase 2
32 Hormones Phase 1, Phase 2
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
34 Immunoglobulins Phase 1, Phase 2
35 Mitogens Phase 1, Phase 2
36 Vaccines Phase 1, Phase 2
37 Omega 3 Fatty Acid Nutraceutical Phase 1, Phase 2
38
Desipramine Approved Phase 1 50-47-5 2995
39 Adrenergic Agents Phase 1
40 Antidepressive Agents Phase 1
41 Antidepressive Agents, Tricyclic Phase 1
42 Neurotransmitter Agents Phase 1
43 Neurotransmitter Uptake Inhibitors Phase 1
44 Psychotropic Drugs Phase 1
45
Fenofibrate Approved 49562-28-9 3339
46 Hypolipidemic Agents
47 Lipid Regulating Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Safety and Efficacy of Abatacept in Patients With Diffuse Systemic Sclerosis (Scleroderma) Completed NCT00442611 Phase 1, Phase 2 Abatacept;Abatacept
2 QUILT-3.044: NANT Non-small Cell Lung Cancer (NSCLC) Vaccine: Combination Immunotherapy in Subjects With NSCLC Who Have Progressed After Treatment With PD-1/PD-L1 Inhibitors Not yet recruiting NCT03169738 Phase 1, Phase 2 Capecitabine;Cisplatin;cyclophosphamide;5-Fluorouracil (5-FU);fulvestrant;leucovorin;nab paclitaxel;Lovaza;Oxaliplatin
3 Study of VX-770 on Desipramine Completed NCT01153542 Phase 1 VX-770;VX-770
4 Detection and Characterization of COPD in Dairy Farmers Completed NCT02540408
5 Epidemiology and Pulmonary Response To Organic Dust Exposure Completed NCT00005288
6 COPD MSA 3 Regions: Epidemiology and Risk Factors of COPD in Rural Environment (BM3R) Completed NCT03299907
7 Lipid Biomarkers for Diabetic Heart Disease Recruiting NCT01752842 Fenofibrate;Placebo for fenofibrate
8 Pulmonary Hypertension in Hypersensitivity Pneumonitis Enrolling by invitation NCT03030807

Search NIH Clinical Center for Farmer's Lung

Cochrane evidence based reviews: farmer's lung

Genetic Tests for Farmer's Lung

Anatomical Context for Farmer's Lung

MalaCards organs/tissues related to Farmer's Lung:

39
Lung, Testes, Endothelial, Heart, Skin, Neutrophil, B Cells

Publications for Farmer's Lung

Articles related to Farmer's Lung:

(show top 50) (show all 339)
id Title Authors Year
1
Farmer's lung disease: Analysis of 75 cases. ( 28587854 )
2017
2
Emphysema in active farmer's lung disease. ( 28614400 )
2017
3
Identification of Antigenic Proteins from Lichtheimia corymbifera for Farmer's Lung Disease Diagnosis. ( 27490813 )
2016
4
Farmer's Lung Disease. A Review. ( 26874898 )
2016
5
Western blotting as a tool for the serodiagnosis of farmer's lung disease: validation with Lichtheimia corymbifera protein extracts. ( 25666836 )
2015
6
Immunoreactive proteins of Saccharopolyspora rectivirgula for farmer's lung serodiagnosis. ( 25264606 )
2014
7
Prevalence and Risk Factors for Farmer's Lung in Greenhouse Farmers: An Epidemiological Study of 5,880 Farmers from Northeast China. ( 25344645 )
2014
8
Draft Genome Sequence of the Principal Etiological Agent of Farmer's Lung Disease, Saccharopolyspora rectivirgula. ( 25523783 )
2014
9
Farmer's lung in a case after bullectomy. ( 22398814 )
2012
10
Aspergillus species recombinant antigens for serodiagnosis of farmer's lung disease. ( 22608571 )
2012
11
Farmer's lung-induced hypersensitivity pneumonitis complicated by shock. ( 22005584 )
2012
12
Excellent visual outcome following Aspergillus flavus endogenous endophthalmitis-farmer's lung disease. ( 19132296 )
2010
13
Comparison of three antigenic extracts of Eurotium amstelodami in serological diagnosis of farmer's lung disease. ( 19906892 )
2010
14
New evidence of the involvement of Lichtheimia corymbifera in farmer's lung disease. ( 20353311 )
2010
15
Multilevel analysis of the impact of environmental factors and agricultural practices on the concentration in hay of microorganisms responsible for farmer's lung disease. ( 20047254 )
2009
16
Elevated levels of beta-D-glucan in bronchoalveolar lavage fluid in patients with farmer's lung in Miyazaki, Japan. ( 17202807 )
2008
17
Pesticides and other agricultural factors associated with self-reported farmer's lung among farm residents in the Agricultural Health Study. ( 17182642 )
2007
18
Farmer's lung is now in decline. ( 16986564 )
2006
19
Farmer's lung disease and microbiological composition of hay: a case-control study. ( 16244894 )
2005
20
Evaluation of salting as a hay preservative against farmer's lung disease agents. ( 16457476 )
2005
21
Microbiological evolution of hay and relapse in patients with farmer's lung. ( 14691284 )
2004
22
Farmer's lung. ( 15529581 )
2003
23
Long-term sequelae of Farmer's lung disease in HRCT: a 14-year follow-up study of 88 patients and 83 matched control farmers. ( 12928967 )
2003
24
Occurrence of farmer's lung disease is relevant to meteorological conditions: a 20-year follow-up field survey analysis. ( 12173376 )
2002
25
The risk of asthma among Finnish patients with farmer's lung. ( 12373322 )
2002
26
Role of molds in farmer's lung disease in Eastern France. ( 11401869 )
2001
27
Tumor necrosis factor-alpha -308 promoter gene polymorphism and increased tumor necrosis factor serum bioactivity in farmer's lung patients. ( 11179110 )
2001
28
Pulmonary glutathione levels in acute episodes of Farmer's lung. ( 10852775 )
2000
29
High-resolution computed tomographic characteristics in acute farmer's lung and in its follow-up. ( 10933085 )
2000
30
Saccharopolyspora rectivirgula from Quebec dairy barns: application of simplified criteria for the identification of an agent responsible for farmer's lung disease. ( 9989646 )
1999
31
IgG antibodies, chronic bronchitis, and pulmonary function values in farmer's lung patients and matched controls. ( 10604554 )
1999
32
Farmer's lung in Ireland (1983-1996) remains at a constant level. ( 10098338 )
1999
33
Long-term risk of emphysema in patients with farmer's lung and matched control farmers. ( 9700147 )
1998
34
Role of interleukin-2 in the development and persistence of lymphocytic alveolitis in farmer's lung. ( 9657567 )
1998
35
Diagnostic accuracy of transbronchial biopsy in acute farmer's lung disease. ( 9404739 )
1997
36
Cardiopulmonary exercise testing following hay exposure challenge in farmer's lung. ( 9387965 )
1997
37
Asthma in patients with farmer's lung during a five-year follow-up. ( 9167238 )
1997
38
IgE antibody response against Aspergillus umbrosus in farmer's lung disease. ( 9066519 )
1997
39
Fatal cases of farmer's lung in a Canadian family. Probable new antigens, Penicillium brevicompactum and P olivicolor. ( 8996026 )
1997
40
Long-term outcome of pulmonary function in farmer's lung: a 14 year follow-up with matched controls. ( 9311500 )
1997
41
[Relationship between severity of farmer's lung and the level of soluble interleukin 2 receptors in serum]. ( 8937141 )
1996
42
Farmer's lung: patients' IgG2 antibodies specifically recognize Saccharopolyspora rectivirgula proteins and carbohydrate structures. ( 8757222 )
1996
43
Identification of the reactive subunits of Aspergillus umbrosus involved in the antigenic response in farmer's lung. ( 8809426 )
1996
44
Viral infection enhances the response to Saccharopolyspora rectivirgula in mice prechallenged with this farmer's lung antigen. ( 8887935 )
1996
45
Effect of contact avoidance or treatment with oral prednisolone on bronchoalveolar lavage surfactant protein A levels in subjects with farmer's lung. ( 8994517 )
1996
46
Elafin/elastase-specific inhibitor in bronchoalveolar lavage of normal subjects and farmer's lung. ( 8887613 )
1996
47
Smoking promotes insidious and chronic farmer's lung disease, and deteriorates the clinical outcome. ( 8563097 )
1995
48
Farmer's lung and variables related to the decision to quit farming. ( 7663816 )
1995
49
Detection of specific antibodies in immune complexes of farmer's lung patients. ( 8705008 )
1995
50
Mortality due to farmer's lung in Finland. ( 7774328 )
1994

Variations for Farmer's Lung

Expression for Farmer's Lung

Search GEO for disease gene expression data for Farmer's Lung.

Pathways for Farmer's Lung

GO Terms for Farmer's Lung

Cellular components related to Farmer's Lung according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CD36 CD79A TNF
2 membrane raft GO:0045121 8.8 CD36 CD79A TNF

Biological processes related to Farmer's Lung according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of MAP kinase activity GO:0043406 9.48 ELANE TNF
2 positive regulation of smooth muscle cell proliferation GO:0048661 9.46 ELANE TNF
3 antimicrobial humoral response GO:0019730 9.43 ELANE PI3
4 MAPK cascade GO:0000165 9.43 IL2 PSMA1 TNF
5 positive regulation of interleukin-6 production GO:0032755 9.4 CD36 TNF
6 positive regulation of interferon-gamma production GO:0032729 9.32 IL2 TNF
7 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.16 ELANE TNF
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.07 TNF
9 positive regulation of blood microparticle formation GO:2000334 8.96 CD36 TNF
10 negative regulation of growth of symbiont in host GO:0044130 8.8 CD36 ELANE TNF

Sources for Farmer's Lung

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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