Farmer's Lung disease: drugs, articles, genes, clinical trials

Summaries for Farmer's Lung

Sources:
⁶Disease Ontology, ²²MalaCards
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Disease Ontology: An extrinsic allergic alveolitis which is induced by the inhalation of spores (aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. it is characterized by sudden onset, fever, cough, expectoration, and breathlessness.⁶

MalaCards: Farmer's Lung, also known as farmers lung, is related to interstitial lung disease and extrinsic allergic alveolitis. An important gene associated with Farmer's Lung is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and LDL Oxidation in Atherogenesis. The compounds mycophenolic acid and lenalidomide have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Descriptions for Farmer's Lung

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Sources:
⁶Disease Ontology, ³⁰NIH Rare Diseases, ⁴³UMLS, ⁸DISEASES, ³²Novoseek , ⁴⁰SNOMED-CT, ²⁴MeSH, ²⁷NCIt, ¹⁹ICD9CM
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Aliases & Descriptions:

farmer's lung ⁶ ³⁰ ⁴³

farmers lung ⁶ ⁸ ³²

farmers' lung (disorder) ⁶

farmers' lung ⁶

External Ids:

MeSH²⁴ D005203

NCIt²⁷ C34605

SNOMED-CT⁴⁰ 18690003, 155581001, 266399001

ICD9CM¹⁹ 495.0

UMLS⁴³ C0015634

Related Diseases for Farmer's Lung

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Sources:
¹³GeneCards, ¹⁴GeneDecks
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Diseases related to farmer's lung by text searches and GeneDecks gene sharing:

(show top 50) (show all 296)

id	Related Disease	Score	Top Affiliating Genes
1	interstitial lung disease	29.6	IL2, IL2RA, TNF
2	extrinsic allergic alveolitis	13.2	PI3, IL2RA
3	intermediate uveitis	13.2	IL2RA, TNF
4	t-cell large granular lymphocyte leukemia	13.2	IL2RA, TNF
5	cystic echinococcosis	13.1	IL2RA, IGHE
6	autoimmune lymphoproliferative syndrome	13.1	IL2RA, IGHE
7	limited scleroderma	13.1	IL2, IL2RA
8	localized scleroderma	13.1	CD36, IL2RA
9	subacute thyroiditis	13.1	IL2RA, TNF
10	hematologic cancer	13.1	IL2, IL2RA
11	htlv-1 associated myelopathy/tropical spastic paraparesis	13.1	IL2, IL2RA
12	erysipelas	13.1	PI3, TNF
13	coronary heart disease	13.0	CD36, TNF
14	tropical spastic paraparesis	13.0	IL2, IL2RA
15	diffuse infiltrative lymphocytosis syndrome	13.0	IL2, IL2RA
16	hypergammaglobulinemia	13.0	IL2RA, IGHE
17	htlv-1 associated myelopathy	13.0	IL2, IL2RA
18	netherton syndrome	13.0	PI3, IGHE
19	staphylococcal toxic shock syndrome	13.0	IGHE, TNF
20	microscopic polyangiitis	13.0	IL2RA, TNF
21	immune defect due to absence of thymus	13.0	IL2, IL2RA
22	gamma chain deficiency	13.0	IL2, IL2RA
23	vernal keratoconjunctivitis	13.0	CD36, IGHE
24	skin conditions	12.9	IGHE, TNF
25	sezary's disease	12.9	IL2, IL2RA
26	oral tuberculosis	12.9	IL2, TNF
27	cysticercosis	12.9	IGHE, TNF
28	poems syndrome	12.9	CD36, TNF
29	coronary artery aneurysm	12.9	IGHE, TNF
30	egg allergy	12.9	IL2, IGHE
31	cerebral malaria	12.9	CD36, TNF
32	omenn syndrome	12.9	IGHE, TNF
33	hypersensitivity reaction type iv disease	12.9	IL2, IGHE
34	lymphatic system disease	12.8	IL2, TNF
35	burning mouth syndrome	12.8	IL2, TNF
36	cytomegalovirus retinitis	12.8	IL2, TNF
37	multidrug-resistant tuberculosis	12.8	IL2, TNF
38	collagen disease	12.8	CD36, IL2RA, TNF
39	hairy cell leukemia	12.8	IL2, IL2RA
40	crescentic glomerulonephritis	12.8	CD36, IL2RA, TNF
41	pasteurellosis	12.7	PI3, SLPI
42	arterial calcification	12.7	CD36, IL2RA, TNF
43	posterior uveitis	12.7	IL2RA, IGHE, TNF
44	panniculitis	12.7	IL2RA, IGHE, TNF
45	autoimmune pancreatitis	12.7	IL2RA, IGHE, TNF
46	echinococcosis	12.7	IL2RA, IGHE, TNF
47	mumps	12.7	IL2RA, IGHE, TNF
48	cutaneous leishmaniasis	12.7	IL2RA, IGHE, TNF
49	autoimmune myocarditis	12.7	IL2, TNF
50	keratitis	12.7	IL2RA, IGHE, TNF

Graphical network of the top 20 diseases related to farmer's lung:

Graphical network of diseases related to farmer's lung

Clinical Features for Farmer's Lung

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Drugs & Therapeutics for Farmer's Lung

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Sources:
⁴CenterWatch, ²⁹NIH Clinical Center, ⁵ClinicalTrials, ⁴³UMLS, ²⁸NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for farmer's lung

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Genetic Tests for Farmer's Lung

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Anatomical Context for Farmer's Lung

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Sources:
²²MalaCards
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MalaCards organs/tissues related to farmer's lung:

²²

Lung

Phenotypes for genes affiliated with Farmer's Lung

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²⁵MGI
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MGI Mouse Phenotypes related to farmer's lung:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	9.3	IL2, TNF
2	hematopoietic system phenotype	MP:0005397	6.9	CD36, IL2, IL2RA, IGHE, TNF, SLPI

Publications for genes affiliated with Farmer's Lung

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³⁵PubMed
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Articles related to farmer's lung:

id	Title	Authors	Year	Affiliating Genes
1	Tumor necrosis factor-alpha -308 promoter gene polymorphism and increased tumor necrosis factor serum bioactivity in farmer's lung patients. (11179110)	Schaaf B.M.... Zabel P.	2001	TNF
2	Role of interleukin-2 in the development and persistence of lymphocytic alveolitis in farmer's lung. (9657567)	Dakhama A.... Cormier Y.	1998	IL2
3	IgE antibody response against Aspergillus umbrosus in farmer's lung disease. (9066519)	Kaukonen K.... Terho E.O.	1997	IGHE
4	Elafin/elastase-specific inhibitor in bronchoalveolar lavage of normal subjects and farmer's lung. (8887613)	Tremblay G.M.... Gauldie J.	1996	PI3, SLPI
5	Relationship between severity of farmer's lung and the level of soluble interleukin 2 receptors in serum (8937141)	Fukuzawa J.... Kikuchi K.	1996	IL2RA
6	Complete clarification of a case of farmer's lung. (1624211)	Wick G.... Krejci H.	1992	CD36
7	A study on interleukin 2 and soluble interleukin 2 receptor in serum and bronchoalveolar lavage fluid from patients with farmer's lung (1770680)	Ninomiya Y.... Konishi K.	1991	IL2RA

Genes related to Farmer's Lung

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¹³GeneCards
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Genes related to farmer's lung according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
2	EAPP	E2F-associated phosphoprotein	11.0
3	SLC7A4	solute carrier family 7 (orphan transporter), member 4	11.0
4	PI3	peptidase inhibitor 3, skin-derived	11.0	Publications
5	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
6	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
7	IL2	interleukin 2	11.0	Publications
8	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
9	TNF	tumor necrosis factor	11.0	Publications

Expression for genes affiliated with Farmer's Lung

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¹BioGPS
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Expression patterns in normal tissues for genes affiliated with Farmer's Lung

Pathways for genes affiliated with Farmer's Lung

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Sources:
³⁷R&D Systems, ³⁶QIAGEN, ⁴¹Thomson Reuters, ²⁰KEGG, ¹⁰EMD Millipore
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Pathways related to farmer's lung according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types³⁷	9.7	IL2, IL2RA
2	LDL Oxidation in Atherogenesis³⁶	9.5	CD36, TNF
3	Immune response_MIF-mediated glucocorticoid regulation⁴¹	9.3	IL2, TNF
4	Hematopoietic cell lineage²⁰	9.3	CD36, IL2RA, TNF
5	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types³⁷	9.2	IL2, IL2RA, TNF
6	THC Differentiation Pathway³⁶	9.2	TNF, IL2RA, IL2
7	Apoptotic Pathways in Synovial Fibroblasts³⁶	9.1	TNF, IL2RA, IL2
8	Immune response MIF-mediated glucocorticoid regulation¹⁰	9.0	IL2, TNF
9	Cellular Apoptosis Pathway³⁶	9.0	IL2, IL2RA, TNF
10	PPAR Pathway³⁶	8.9	TNF, IL2RA, IL2

Compounds for genes affiliated with Farmer's Lung

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Sources:
³²Novoseek , ⁹DrugBank, ⁴²Tocris Bioscience, ³⁴PharmGKB, ¹⁸HMDB
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Compounds related to farmer's lung according to GeneDecks:

(show top 50) (show all 79)

id	Compound	Score	Top Affiliating Genes
1	mycophenolic acid³² ⁹ ⁹	12.3	IL2
2	lenalidomide³² ⁹ ⁹	12.0	TNF
3	ro 26-4550 trifluoroacetate⁴²	9.9	IL2, IL2RA
4	vegf³²	9.9	CD36, SLPI
5	mizoribine³²	9.8	IL2, IL2RA
6	denileukin diftitox³² ³⁴ ⁹ ⁹	12.8	IL2RA, IL2
7	mifepristone³² ⁴² ⁹ ⁹	12.7	SLPI, PI3
8	etidronate³²	9.7	SLPI, CD36
9	lamivudine³² ⁹ ⁹	11.6	CD36, IL2RA, SLPI
10	as 101³²	9.6	IL2, IL2RA
11	interferon gamma³²	9.6	IL2, TNF
12	25-hydroxyvitamin d³²	9.6	SLPI, IL2RA, CD36
13	pentostatin³² ⁴² ⁹ ⁹	12.5	IL2, IL2RA
14	piclamilast³² ⁹ ⁹	11.5	TNF, IL2
15	gold sodium thiomalate³²	9.4	TNF, IL2RA, IL2
16	okt3³²	9.4	TNF, IL2RA, IL2
17	mycophenolate mofetil³² ⁹ ⁹	11.4	CD36, IL2, IL2RA
18	alizarin³²	9.4	SLPI, CD36
19	2,5-oligoadenylate³²	9.4	TNF, IL2RA, IL2
20	il 10³²	9.4	TNF, IL2RA, IL2
21	pentoxifylline³² ⁹ ⁹	11.4	IL2, IL2RA, TNF
22	neopterin³²	9.3	IL2, IL2RA, TNF
23	rituximab³² ³⁴ ⁹ ⁹	12.3	TNF, IL2RA, IL2
24	benzylpenicillin³²	9.3	IGHE, IL2
25	zoledronic acid³²	9.3	CD36, IL2, SLPI
26	azathioprine³² ³⁴ ⁹ ⁹	12.3	IL2, IL2RA, SLPI
27	chloroquine³² ³⁴ ⁹ ⁹	12.3	IL2, IL2RA, TNF
28	c-d4t³²	9.2	IL2RA, IL2
29	infliximab³² ⁹ ⁹	11.2	IL2RA, IGHE, TNF
30	glucosamine³² ⁹ ¹⁸ ⁹	12.2	TNF, IL2, CD36
31	thalidomide³² ⁴² ⁹ ⁹	12.2	CD36, IL2, TNF
32	fluticasone propionate³² ⁴² ⁹ ⁹	12.1	IGHE, TNF, SLPI
33	budesonide³² ⁴² ⁹ ⁹	12.0	TNF, IGHE, CD36
34	rantes³²	8.9	IL2, IL2RA, TNF, SLPI
35	herbimycin a³² ⁴²	9.9	TNF, IL2RA, IL2, CD36
36	tacrolimus³² ³⁴ ⁹ ⁹	11.9	TNF, IL2RA, IL2, CD36
37	levamisole³² ⁹ ⁹	10.7	IL2, IL2RA, IGHE, SLPI
38	ascorbic acid³² ¹⁸	9.7	SLPI, IGHE, IL2RA, CD36
39	vitamin d³²	8.7	CD36, IL2RA, IGHE, SLPI
40	prednisolone³² ⁹ ⁹	10.6	IL2, IL2RA, IGHE, TNF
41	indomethacin³² ⁹ ⁹	10.5	TNF, IGHE, IL2RA, IL2
42	calcitriol³² ⁴² ⁹ ¹⁸ ⁹	12.5	CD36, IL2, IL2RA, TNF, SLPI
43	genistein³² ⁹ ¹⁸ ⁹	11.5	SLPI, TNF, IL2RA, IL2, CD36
44	pge2³²	8.5	SLPI, TNF, IL2RA, IL2, CD36
45	actinomycin d³²	8.3	SLPI, TNF, IGHE, IL2
46	hydrocortisone³² ⁹ ⁹	10.0	SLPI, TNF, IGHE, IL2, CD36
47	cycloheximide³²	7.9	CD36, IL2, IGHE, TNF, SLPI
48	histamine³² ¹⁸	8.8	SLPI, TNF, IGHE, IL2RA, IL2, PI3
49	cyclosporin a³² ⁴²	8.8	SLPI, TNF, IGHE, IL2RA, IL2, PI3
50	dexamethasone³² ⁴² ³⁴ ⁹ ⁹	11.2	SLPI, TNF, IGHE, IL2RA, IL2, CD36

GO Terms for genes affiliated with Farmer's Lung

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¹²Gene Ontology
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Biological processes related to farmer's lung according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of growth of symbiont in host	GO:044130	9.4	CD36, TNF
2	negative regulation of viral genome replication	GO:045071	9.4	TNF, SLPI
3	positive regulation of interferon-gamma production	GO:032729	9.3	IL2, TNF
4	negative regulation of endopeptidase activity	GO:010951	9.3	PI3, SLPI