MCID: FRM003
MIFTS: 46

Farmer's Lung malady

Rare diseases, Respiratory diseases, Immune diseases categories

Aliases & Classifications for Farmer's Lung

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Farmer's Lung, Aliases & Descriptions:

Name: Farmer's Lung 9 41 60
Farmers Lung 9 11 43
 
Farmer's Lung Disease 47
Farmer Lung 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases, Immune diseases


External Ids:

Disease Ontology9 DOID:14453
ICD9CM27 495.0
MeSH33 D005203
NCIt38 C34605
Orphanet47 99906
MESH via Orphanet34 D005203
ICD10 via Orphanet26 J67.0
UMLS via Orphanet61 C0015634
ICD1025 J67.0

Summaries for Farmer's Lung

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Disease Ontology:9 An extrinsic allergic alveolitis which is induced by the inhalation of spores (aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. it is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

MalaCards based summary: Farmer's Lung, also known as farmers lung, is related to extrinsic allergic alveolitis and erysipelas. An important gene associated with Farmer's Lung is PI3 (peptidase inhibitor 3, skin-derived), and among its related pathways are Inflammatory Response Pathway and IL2-mediated signaling events. The compounds mizoribine and denileukin diftitox have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and skin, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Related Diseases for Farmer's Lung

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Diseases related to Farmer's Lung via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1extrinsic allergic alveolitis30.6IL2RA, PI3
2erysipelas10.5PI3
3trichomoniasis10.5SLPI
4periapical granuloma10.5IL2RA
5netherton syndrome10.4IGHE
6sinusitis10.4IGHE
7ulcerative colitis10.4TNF
8leprosy10.3IL2
9splenomegaly10.3SLPI, IL2RA
10bronchiectasis10.2SLPI, IGHE
11bronchitis10.2IGHE, SLPI
12hypereosinophilic syndrome10.2IL2RA, IGHE
13acute respiratory distress syndrome10.2PI3, TNF
14hepatitis b10.2IL2RA, SLPI
15mastocytosis10.2IL2RA, IGHE
16marchiafava bignami disease10.2SLPI, CD36
17renal osteodystrophy10.2CD36, SLPI
18localized scleroderma10.2IL2RA, CD36
19secondary hyperparathyroidism of renal origin10.2CD36, SLPI
20juvenile rheumatoid arthritis10.2TNF, IL2RA
21behcet's disease10.2IL2RA, TNF
22osteomalacia10.2SLPI, CD36
23peritonitis10.2SLPI, TNF
24rickets10.2CD36, SLPI
25vernal keratoconjunctivitis10.2CD36, IGHE
26malaria10.1TNF, CD36
27tropical spastic paraparesis10.1IL2RA, IL2
28uveitis10.1TNF, IL2RA
29pulmonary disease, chronic obstructive10.1SLPI, TNF, PI3
30sezary's disease10.1IL2RA, IL2
31pneumonia10.1SLPI, TNF, PI3
32severe combined immunodeficiency, x-linked10.1IL2RA, IL2
33rheumatic disease10.1TNF, IL2RA
34common variable immunodeficiency10.1IL2, IL2RA
35diabetes mellitus, insulin-dependent10.1TNF, CD36
36hcl-v10.1IL2RA, IL2
37toxic shock syndrome10.0TNF, IL2
38pulmonary tuberculosis10.0IL2, IL2RA
39skin disease10.0PI3, IGHE, TNF
40mycosis fungoides10.0IL2, IL2RA
41lymphopenia10.0IL2RA, IL2
42cork-handlers' disease10.0SLPI, IL2
43secondary syphilis10.0SLPI, CD36
44cutaneous t cell lymphoma10.0IL2, IL2RA
45periodontitis10.0SLPI, CD36, TNF
46periodontal disease10.0TNF, CD36, SLPI
47severe combined immunodeficiency10.0IL2, IL2RA
48osteoarthritis9.9TNF, CD36, SLPI
49diphtheria9.9IL2RA, IL2
50tetanus9.9IL2RA, IL2

Graphical network of the top 20 diseases related to Farmer's Lung:



Diseases related to farmer's lung

Symptoms for Farmer's Lung

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Drugs & Therapeutics for Farmer's Lung

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Drug clinical trials:

Search ClinicalTrials for Farmer's Lung

Search NIH Clinical Center for Farmer's Lung

Genetic Tests for Farmer's Lung

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Anatomical Context for Farmer's Lung

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MalaCards organs/tissues related to Farmer's Lung:

31
Lung, Testes, Skin, B cells, Neutrophil

Animal Models for Farmer's Lung or affiliated genes

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MGI Mouse Phenotypes related to Farmer's Lung:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.2TNF, IL2, IL2RA, CD36
2MP:00053767.5SLPI, CD36, IL2, TNF, IGHE
3MP:00053977.1SLPI, CD36, IL2RA, IL2, TNF, IGHE
4MP:00053877.0IGHE, TNF, IL2, IL2RA, CD36, SLPI

Publications for Farmer's Lung

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Articles related to Farmer's Lung:

(show top 50)    (show all 331)
idTitleAuthorsYear
1
Immunoreactive proteins of Saccharopolyspora rectivirgula for farmer's lung serodiagnosis. (25264606)
2014
2
Pesticides and other agricultural factors associated with self-reported farmer's lung among farm residents in the Agricultural Health Study. (17182642)
2007
3
Farmer's lung is now in decline. (16986564)
2006
4
Farmer's lung disease and microbiological composition of hay: a case-control study. (16244894)
2005
5
Evaluation of salting as a hay preservative against farmer's lung disease agents. (16457476)
2005
6
Farmer's lung. (15529581)
2003
7
Tumor necrosis factor-alpha -308 promoter gene polymorphism and increased tumor necrosis factor serum bioactivity in farmer's lung patients. (11179110)
2001
8
High-resolution computed tomographic characteristics in acute farmer's lung and in its follow-up. (10933085)
2000
9
Saccharopolyspora rectivirgula from Quebec dairy barns: application of simplified criteria for the identification of an agent responsible for farmer's lung disease. (9989646)
1999
10
Long-term outcome of pulmonary function in farmer's lung: a 14 year follow-up with matched controls. (9311500)
1997
11
Farmer's lung: patients' IgG2 antibodies specifically recognize Saccharopolyspora rectivirgula proteins and carbohydrate structures. (8757222)
1996
12
Farmer's lung and variables related to the decision to quit farming. (7663816)
1995
13
Mortality due to farmer's lung in Finland. (7774328)
1994
14
Monoclonal antibodies against farmer's lung antigens having specific binding to IgG antibodies. (8400887)
1993
15
Comparison of methods of production of farmer's lung antigens. (1282842)
1992
16
Farmer's lung in infants and small children. (2719181)
1989
17
Bronchoalveolar mastocytosis in farmer's lung is related to the disease activity. (3377620)
1988
18
Epidemiological study of farmer's lung in five districts of the French Doubs province. (3420554)
1988
19
Protective value of powered dust respirator helmet for farmers with farmer's lung. (3478219)
1987
20
Prevalence of serum precipitins against microbes in mouldy hay, and of chronic bronchitis and farmer's lung with respect to farmers' occupational health hazards. (3478212)
1987
21
Prognostic significance of bronchoalveolar lymphocytosis in farmer's lung. (3826894)
1987
22
IgG subclasses in farmer's lung. (3480825)
1987
23
Farmer's lung after Mycoplasma pneumoniae infection. (3704970)
1986
24
Enzyme-linked immunofiltration assay (ELIFA) for the detection of specific antibodies (IgG-IgM-IgA-IgE) in farmer's lung disease. (2431808)
1986
25
Immunohistochemical identification of Aspergillus fumigatus in farmer's lung. (6441428)
1984
26
Importance of anti-lung antibody in farmer's lung disease. (6837583)
1983
27
Antigenic determinants on B cells of farmer's lung patients. (6180923)
1982
28
Farmer's lung disease in Vermont. (375344)
1979
29
Farmer's lung disease among farmers with precipitating antibodies to the thermophilic actinomycetes: a clinical and immunologic study. (681631)
1978
30
The use of antigens grown at different temperatures in the diagnosis of Farmer's lung disease. (651569)
1978
31
Antibodies of different immunoglobulin classes against antigens causing farmer's lung. (823846)
1976
32
Letter: Farmer's lung: a neglected antigen. (57352)
1976
33
Farmer's lung. (4846024)
1974
34
A bovine disease similar to farmer's lung: extrinsic allergic alveolitis. (4252199)
1971
35
Farmer's lung--an acute or chronic disease? (5273209)
1970
36
Farmer's Lung in Urbanites. (20468586)
1970
37
Farmer's lung. (4976124)
1969
38
The pathology of the acute and chronic stages of farmer's lung. (5680234)
1968
39
Farmer's lung. (5253275)
1968
40
Farmer's lung: a study of an early acute fatal case. (4234473)
1968
41
Farmer's lung. (6075681)
1967
42
Farmer's lung as observed in chest survey clinics. (5215338)
1965
43
Farmer's lung scheduled as a prescribed occupational disease in Great Britain. (5831722)
1965
44
Farmer's lung. Report of a case, with lung biopsy. (13941062)
1963
45
Antigens in moldy hay as the cause of farmer's lung. (14033919)
1963
46
A Survey of " Farmer's Lung ". (19790385)
1961
47
Farmer's lung: a case report. (13881136)
1961
48
A syndrome resembling farmer's lung in workers inhaling spores of Aspergillus and Penicillia moulds. (13715832)
1960
49
Farmer's lung; a form of pneumoconiosis due to organic dusts. (13498211)
1958
50
A case of farmer's lung. (14913703)
1952

Variations for Farmer's Lung

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Expression for genes affiliated with Farmer's Lung

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Search GEO for disease gene expression data for Farmer's Lung.

Pathways for genes affiliated with Farmer's Lung

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Pathways related to Farmer's Lung according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL2RA, IL2
2
Show member pathways
IL-2 Signaling pathway36
9.5IL2, IL2RA
39.5IL2, IL2RA
4
Show member pathways
Immune response IL 3 activation and signaling pathway58
9.5IL2, IL2RA
5
Show member pathways
9.5IL2RA, IL2
6
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.5IL2, IL2RA
7
Show member pathways
IL2 signaling events mediated by STAT536
9.5IL2RA, IL2
89.4CD36, TNF
99.4CD36, TNF
109.4TNF, CD36
11
Show member pathways
IL27-mediated signaling events36
9.3IL2, TNF
129.3IL2, TNF
13
Show member pathways
AhR pathway36
9.3TNF, IL2
149.3TNF, IL2
159.3TNF, IL2
169.0TNF, CD36, IL2RA
17
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.9IL2, IL2RA, TNF
18
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.9IL2, IL2RA, TNF
19
Show member pathways
8.9IL2RA, TNF, IL2
208.9IL2, IL2RA, TNF
21
Show member pathways
8.9TNF, IL2, IL2RA
22
Show member pathways
8.9TNF, IL2, IL2RA
23
Show member pathways
8.9TNF, IL2, IL2RA
24
Show member pathways
8.9TNF, IL2, IL2RA
25
Show member pathways
8.9TNF, IL2RA, IL2
26
Show member pathways
8.9TNF, IL2, IL2RA
27
Show member pathways
Ras signaling in the CD4+ TCR pathway36
8.9TNF, IL2, IL2RA

Compounds for genes affiliated with Farmer's Lung

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Compounds related to Farmer's Lung according to GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1mizoribine439.8IL2, IL2RA
2denileukin diftitox43 49 1211.6IL2RA, IL2
3pirfenidone43 5910.5IL2, CD36, IL2RA
4benzylpenicillin439.4IGHE, IL2
5mycophenolic acid43 49 1211.4IL2, IL2RA, IGHE
6gold sodium thiomalate439.3TNF, IL2, IL2RA
7piclamilast43 1210.3TNF, IL2
8okt3439.3TNF, IL2RA, IL2
92,5-oligoadenylate439.3IL2, TNF, IL2RA
10il 10439.3IL2RA, TNF, IL2
11budesonide43 49 1211.3IGHE, TNF, CD36
12infliximab43 49 1211.3TNF, IL2RA, IGHE
13ivig439.2TNF, IL2RA, IGHE
14pentoxifylline43 1210.2IL2, IL2RA, TNF
15interferon gamma439.2IL2, TNF
16glucosamine43 24 1211.2CD36, IL2, TNF
17neopterin439.2IL2, IL2RA, TNF
18rituximab43 49 1211.2IL2RA, IL2, TNF
19lamivudine43 49 1211.2SLPI, CD36, IL2RA
20chloroquine43 2 49 28 1213.2IL2, TNF, IL2RA
2125-hydroxyvitamin d439.2CD36, IL2RA, SLPI
22zoledronic acid439.1SLPI, IL2, CD36
23mifepristone43 28 59 1212.1PI3, IL2RA, SLPI
24mycophenolate mofetil43 49 1210.9IL2RA, IL2, TNF, CD36
25azathioprine43 2 49 1211.9IL2, IL2RA, SLPI
26thalidomide43 49 59 1211.9TNF, IL2, IL2RA, CD36
27etidronate438.9CD36, SLPI
28fluticasone propionate43 49 59 1211.9IGHE, SLPI, TNF
29herbimycin a43 599.9TNF, IL2RA, CD36, IL2
30tacrolimus43 49 1210.9TNF, IL2, IL2RA, CD36
31prednisolone43 28 1210.8IGHE, IL2RA, TNF, IL2
32indomethacin43 28 59 1211.8IGHE, IL2RA, IL2, TNF
33levamisole43 129.6SLPI, IL2RA, IL2, IGHE
34ascorbic acid43 249.6CD36, IL2RA, SLPI, IGHE
35vitamin d438.6SLPI, CD36, IL2RA, IGHE
36rantes438.5IL2, TNF, IL2RA, SLPI
37creatinine438.4IL2RA, IGHE, CD36, SLPI
38heparin43 28 24 1211.4CD36, IL2RA, IGHE, SLPI
39thymidine43 249.3SLPI, IL2RA, TNF, IL2
40actinomycin d438.3IGHE, TNF, IL2, SLPI
41calcitriol43 59 24 1211.1TNF, IL2, IL2RA, CD36, SLPI
42genistein43 28 59 2 24 1213.1IL2, SLPI, CD36, IL2RA, TNF
43pge2438.1IL2RA, SLPI, CD36, IL2, TNF
44retinoic acid43 249.0TNF, IGHE, CD36, SLPI, PI3
45hydrocortisone43 2 59 1211.0SLPI, IL2, IGHE, CD36, TNF
46cycloheximide437.9IGHE, SLPI, CD36, IL2, TNF
47histamine43 28 249.7PI3, SLPI, IL2RA, TNF, IGHE, IL2
48cyclosporin a43 28 599.6TNF, IL2, IL2RA, SLPI, IGHE, PI3
49vegf437.6IL2RA, CD36, IGHE, TNF, IL2, SLPI
50dexamethasone43 49 28 1210.2IL2, SLPI, IL2RA, IGHE, PI3, TNF

GO Terms for genes affiliated with Farmer's Lung

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Cellular components related to Farmer's Lung according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.0CD36, IL2RA, TNF

Biological processes related to Farmer's Lung according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell homeostatic proliferationGO:00460139.8IL2RA, IL2
2positive regulation of activated T cell proliferationGO:00421049.7IL2, IL2RA
3negative regulation of growth of symbiont in hostGO:00441309.6CD36, TNF
4defense response to Gram-positive bacteriumGO:00508309.5CD36, TNF
5positive regulation of interferon-gamma productionGO:00327299.4TNF, IL2
6positive regulation of interleukin-6 productionGO:00327559.3TNF, CD36
7negative regulation of endopeptidase activityGO:00109519.3SLPI, PI3
8negative regulation of inflammatory responseGO:00507289.2IL2RA, IL2
9negative regulation of viral genome replicationGO:00450719.2SLPI, TNF
10immune responseGO:00069559.0IL2RA, IL2, IGHE

Molecular functions related to Farmer's Lung according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00048669.3SLPI, PI3

Products for genes affiliated with Farmer's Lung

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Sources for Farmer's Lung

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet