MCID: FRM003
MIFTS: 47

Farmer's Lung malady

Categories: Rare diseases, Respiratory diseases, Immune diseases

Aliases & Classifications for Farmer's Lung

Aliases & Descriptions for Farmer's Lung:

Name: Farmer's Lung 12 50 42 14 69
Farmers Lung 12 52
Farmer's Lung Disease 56
Farmer Lung 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14453
ICD10 33 J67.0
ICD9CM 35 495.0
MeSH 42 D005203
NCIt 47 C34605
Orphanet 56 ORPHA99906
MESH via Orphanet 43 D005203
ICD10 via Orphanet 34 J67.0
UMLS via Orphanet 70 C0015634
UMLS 69 C0015634

Summaries for Farmer's Lung

Disease Ontology : 12 An extrinsic allergic alveolitis which is induced by the inhalation of spores (Aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. It is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

MalaCards based summary : Farmer's Lung, also known as farmers lung, is related to steatitis and louse-borne relapsing fever. An important gene associated with Farmer's Lung is IL2 (Interleukin 2), and among its related pathways/superpathways are Innate Immune System and Immune response NFAT in immune response. The drugs Abatacept and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and skin, and related phenotypes are hematopoietic system and immune system

Related Diseases for Farmer's Lung

Diseases related to Farmer's Lung via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 233)
id Related Disease Score Top Affiliating Genes
1 steatitis 10.3 IL2 TNF
2 louse-borne relapsing fever 10.3 IL2 PI3
3 autosomal dominant deafness-onychodystrophy syndrome 10.3 IL2 TNF
4 thymic neuroendocrine carcinoma 10.2 IL2 TNF
5 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IL2 TNF
6 tinea capitis 10.2 IL2 TNF
7 amyotrophic lateral sclerosis type 14 10.2 IL2 TNF
8 parametritis 10.2 IL2 TNF
9 cyclosporiasis 10.2 IL2 TNF
10 cerebellar disease 10.2 PI3 TNF
11 neuropathy, hereditary thermosensitive 10.2 CD40LG IL2
12 st. louis encephalitis 10.2 CD40LG IL2
13 submandibular gland disease 10.2 CD40LG TNF
14 ectopic thymus 10.2 CD40LG IL2
15 dermatitis herpetiformis 10.2 CD40LG TNF
16 spotted fever 10.2 CD40LG TNF
17 hepatitis 10.2 IL2 TNF
18 human immunodeficiency virus infectious disease 10.2 CD40LG TNF
19 pulmonary embolism and infarction 10.2 ELANE PI3
20 brucella suis brucellosis 10.2 ELANE PI3
21 acute myeloid leukemia with recurrent genetic anomaly 10.2 IL2 TNF
22 microcephaly 10.2 IL2 TNF
23 acute cor pulmonale 10.2 ELANE PI3
24 congenital hypothyroidism 10.2 CD40LG TNF
25 conduct disorder 10.1 CD40LG TNF
26 pancreatic signet ring cell adenocarcinoma 10.1 CD40LG TNF
27 cryptococcosis 10.1 CD40LG TNF
28 chromoblastomycosis 10.1 ELANE TNF
29 mineral metabolism disease 10.1 CD40LG TNF
30 ceroid lipofuscinosis, neuronal, 11 10.1 CD36 CD40LG
31 abnormal retinal correspondence 10.1 IL2 TNF
32 hereditary alpha tryptasemia syndrome 10.1 CD40LG TNF
33 functional gastric disease 10.1 CD40LG TNF
34 strawberry gallbladder 10.1 IL2 TNF
35 agraphia 10.1 CD36 CD40LG
36 astrocytoma 10.1 CD40LG TNF
37 atelosteogenesis ii 10.1 ELANE PI3
38 bulbospinal polio 10.1 CD40LG IL2
39 fallopian tube carcinoma 10.1 CD79A IL2
40 powassan encephalitis 10.1 CD40LG TNF
41 barbiturate dependence 10.1 CD79A IL2
42 benign deep fibrous histiocytoma 10.1 CD40LG TNF
43 gonadal disease 10.1 CD79A IL2
44 cerebellar liponeurocytoma 10.1 CD40LG IL2 TNF
45 endogenous depression 10.1 CD40LG IL2 TNF
46 alcoholic neuropathy 10.1 CD40LG CD79A
47 camptodactyly vertebral fusion 10.1 CD40LG CD79A
48 tuberculosis 10.1 CD40LG IL2 TNF
49 myiasis 10.1 CD40LG IL2 TNF
50 heart conduction disease 10.1 CD40LG IL2 TNF

Comorbidity relations with Farmer's Lung via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Farmer's Lung:



Diseases related to Farmer's Lung

Symptoms & Phenotypes for Farmer's Lung

MGI Mouse Phenotypes related to Farmer's Lung:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 CD36 CD40LG CD79A ELANE IL2 TNF
2 immune system MP:0005387 9.43 CD36 CD40LG CD79A ELANE IL2 TNF
3 neoplasm MP:0002006 8.92 CD79A ELANE IL2 TNF

Drugs & Therapeutics for Farmer's Lung

Drugs for Farmer's Lung (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 1, Phase 2 332348-12-6 10237
2
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
3
Capecitabine Approved, Investigational Phase 1, Phase 2 154361-50-9 60953
4
Cisplatin Approved Phase 1, Phase 2 15663-27-1 84093 441203 2767
5
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
6
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
7
Fulvestrant Approved, Investigational Phase 1, Phase 2 129453-61-8 104741 17756771
8
nivolumab Approved Phase 1, Phase 2 946414-94-4
9
Oxaliplatin Approved, Investigational Phase 1, Phase 2 61825-94-3 5310940 9887054 6857599, 9887054 43805
10
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
11
leucovorin Approved, Nutraceutical Phase 1, Phase 2 58-05-9 54575, 6560146 143
12 Antirheumatic Agents Phase 1, Phase 2
13 Immunosuppressive Agents Phase 1, Phase 2
14 Hormone Antagonists Phase 1, Phase 2
15 Hormones Phase 1, Phase 2
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
17 Antimetabolites Phase 1, Phase 2
18 Albumin-Bound Paclitaxel Phase 1, Phase 2
19 Alkylating Agents Phase 1, Phase 2
20 Angiogenesis Inhibitors Phase 1, Phase 2
21 Angiogenesis Modulating Agents Phase 1, Phase 2
22 Antibodies Phase 1, Phase 2
23 Antibodies, Monoclonal Phase 1, Phase 2
24 Antimetabolites, Antineoplastic Phase 1, Phase 2
25 Antimitotic Agents Phase 1, Phase 2
26 Antineoplastic Agents, Alkylating Phase 1, Phase 2
27 Antineoplastic Agents, Hormonal Phase 1, Phase 2
28 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
29 Calcium, Dietary Phase 1, Phase 2
30 Endothelial Growth Factors Phase 1, Phase 2
31 Estrogen Antagonists Phase 1, Phase 2
32 Estrogen Receptor Antagonists Phase 1, Phase 2
33 Estrogens Phase 1, Phase 2
34 Immunoglobulins Phase 1, Phase 2
35 Mitogens Phase 1, Phase 2
36 Vaccines Phase 1, Phase 2
37 Glutamic Acid Nutraceutical Phase 1, Phase 2
38 Omega 3 Fatty Acid Nutraceutical Phase 1, Phase 2
39
Desipramine Approved Phase 1 50-47-5 2995
40
Fluconazole Approved Phase 1 86386-73-4 3365
41
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
42
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
43
Rosiglitazone Approved, Investigational Phase 1 122320-73-4 77999
44
Rifampin Approved Phase 1 13292-46-1 5458213 5381226
45 Adrenergic Agents Phase 1
46 Antidepressive Agents Phase 1
47 Antidepressive Agents, Tricyclic Phase 1
48 Neurotransmitter Agents Phase 1
49 Neurotransmitter Uptake Inhibitors Phase 1
50 Psychotropic Drugs Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Study to Evaluate the Safety and Efficacy of Abatacept in Patients With Diffuse Systemic Sclerosis (Scleroderma) Completed NCT00442611 Phase 1, Phase 2
2 QUILT-3.044: NANT Non-small Cell Lung Cancer (NSCLC) Vaccine: Combination Immunotherapy in Subjects With NSCLC Who Have Progressed After Treatment With PD-1/PD-L1 Inhibitors Not yet recruiting NCT03169738 Phase 1, Phase 2
3 Study of VX-770 on Desipramine Completed NCT01153542 Phase 1
4 Study of VX-770 on Midazolam and Rosiglitazone and the Effect of Fluconazole on VX-770 Completed NCT01060566 Phase 1
5 Study of VX-770 and Rifampin in Healthy Male Subjects Completed NCT01018368 Phase 1
6 Detection and Characterization of COPD in Dairy Farmers Completed NCT02540408
7 Epidemiology and Pulmonary Response To Organic Dust Exposure Completed NCT00005288
8 Lipid Biomarkers for Diabetic Heart Disease Recruiting NCT01752842
9 Pulmonary Hypertension in Hypersensitivity Pneumonitis Enrolling by invitation NCT03030807

Search NIH Clinical Center for Farmer's Lung

Cochrane evidence based reviews: farmer's lung

Genetic Tests for Farmer's Lung

Anatomical Context for Farmer's Lung

MalaCards organs/tissues related to Farmer's Lung:

39
Lung, Testes, Skin, Neutrophil, B Cells

Publications for Farmer's Lung

Articles related to Farmer's Lung:

(show top 50) (show all 337)
id Title Authors Year
1
Identification of Antigenic Proteins from Lichtheimia corymbifera for Farmer's Lung Disease Diagnosis. ( 27490813 )
2016
2
Farmer's Lung Disease. A Review. ( 26874898 )
2016
3
Western blotting as a tool for the serodiagnosis of farmer's lung disease: validation with Lichtheimia corymbifera protein extracts. ( 25666836 )
2015
4
Prevalence and Risk Factors for Farmer's Lung in Greenhouse Farmers: An Epidemiological Study of 5,880 Farmers from Northeast China. ( 25344645 )
2014
5
Immunoreactive proteins of Saccharopolyspora rectivirgula for farmer's lung serodiagnosis. ( 25264606 )
2014
6
Draft Genome Sequence of the Principal Etiological Agent of Farmer's Lung Disease, Saccharopolyspora rectivirgula. ( 25523783 )
2014
7
Farmer's lung in a case after bullectomy. ( 22398814 )
2012
8
Aspergillus species recombinant antigens for serodiagnosis of farmer's lung disease. ( 22608571 )
2012
9
Farmer's lung-induced hypersensitivity pneumonitis complicated by shock. ( 22005584 )
2012
10
Excellent visual outcome following Aspergillus flavus endogenous endophthalmitis-farmer's lung disease. ( 19132296 )
2010
11
Comparison of three antigenic extracts of Eurotium amstelodami in serological diagnosis of farmer's lung disease. ( 19906892 )
2010
12
New evidence of the involvement of Lichtheimia corymbifera in farmer's lung disease. ( 20353311 )
2010
13
Multilevel analysis of the impact of environmental factors and agricultural practices on the concentration in hay of microorganisms responsible for farmer's lung disease. ( 20047254 )
2009
14
Elevated levels of beta-D-glucan in bronchoalveolar lavage fluid in patients with farmer's lung in Miyazaki, Japan. ( 17202807 )
2008
15
Pesticides and other agricultural factors associated with self-reported farmer's lung among farm residents in the Agricultural Health Study. ( 17182642 )
2007
16
Farmer's lung is now in decline. ( 16986564 )
2006
17
Farmer's lung disease and microbiological composition of hay: a case-control study. ( 16244894 )
2005
18
Evaluation of salting as a hay preservative against farmer's lung disease agents. ( 16457476 )
2005
19
Microbiological evolution of hay and relapse in patients with farmer's lung. ( 14691284 )
2004
20
Long-term sequelae of Farmer's lung disease in HRCT: a 14-year follow-up study of 88 patients and 83 matched control farmers. ( 12928967 )
2003
21
Farmer's lung. ( 15529581 )
2003
22
The risk of asthma among Finnish patients with farmer's lung. ( 12373322 )
2002
23
Occurrence of farmer's lung disease is relevant to meteorological conditions: a 20-year follow-up field survey analysis. ( 12173376 )
2002
24
Role of molds in farmer's lung disease in Eastern France. ( 11401869 )
2001
25
Tumor necrosis factor-alpha -308 promoter gene polymorphism and increased tumor necrosis factor serum bioactivity in farmer's lung patients. ( 11179110 )
2001
26
Pulmonary glutathione levels in acute episodes of Farmer's lung. ( 10852775 )
2000
27
High-resolution computed tomographic characteristics in acute farmer's lung and in its follow-up. ( 10933085 )
2000
28
IgG antibodies, chronic bronchitis, and pulmonary function values in farmer's lung patients and matched controls. ( 10604554 )
1999
29
Farmer's lung in Ireland (1983-1996) remains at a constant level. ( 10098338 )
1999
30
Saccharopolyspora rectivirgula from Quebec dairy barns: application of simplified criteria for the identification of an agent responsible for farmer's lung disease. ( 9989646 )
1999
31
Long-term risk of emphysema in patients with farmer's lung and matched control farmers. ( 9700147 )
1998
32
Role of interleukin-2 in the development and persistence of lymphocytic alveolitis in farmer's lung. ( 9657567 )
1998
33
Asthma in patients with farmer's lung during a five-year follow-up. ( 9167238 )
1997
34
Cardiopulmonary exercise testing following hay exposure challenge in farmer's lung. ( 9387965 )
1997
35
Diagnostic accuracy of transbronchial biopsy in acute farmer's lung disease. ( 9404739 )
1997
36
Fatal cases of farmer's lung in a Canadian family. Probable new antigens, Penicillium brevicompactum and P olivicolor. ( 8996026 )
1997
37
Long-term outcome of pulmonary function in farmer's lung: a 14 year follow-up with matched controls. ( 9311500 )
1997
38
IgE antibody response against Aspergillus umbrosus in farmer's lung disease. ( 9066519 )
1997
39
Identification of the reactive subunits of Aspergillus umbrosus involved in the antigenic response in farmer's lung. ( 8809426 )
1996
40
Effect of contact avoidance or treatment with oral prednisolone on bronchoalveolar lavage surfactant protein A levels in subjects with farmer's lung. ( 8994517 )
1996
41
Farmer's lung: patients' IgG2 antibodies specifically recognize Saccharopolyspora rectivirgula proteins and carbohydrate structures. ( 8757222 )
1996
42
Elafin/elastase-specific inhibitor in bronchoalveolar lavage of normal subjects and farmer's lung. ( 8887613 )
1996
43
[Relationship between severity of farmer's lung and the level of soluble interleukin 2 receptors in serum]. ( 8937141 )
1996
44
Viral infection enhances the response to Saccharopolyspora rectivirgula in mice prechallenged with this farmer's lung antigen. ( 8887935 )
1996
45
Farmer's lung and variables related to the decision to quit farming. ( 7663816 )
1995
46
Smoking promotes insidious and chronic farmer's lung disease, and deteriorates the clinical outcome. ( 8563097 )
1995
47
Detection of specific antibodies in immune complexes of farmer's lung patients. ( 8705008 )
1995
48
Avidity of Aspergillus umbrosus IgG antibodies in farmer's lung disease. ( 8287601 )
1994
49
Mast cell and histamine involvement in farmer's lung disease. ( 8162747 )
1994
50
Farmer's lung precipitins in Doubs (a department of France): prevalence and diagnostic value. ( 7695064 )
1994

Variations for Farmer's Lung

Expression for Farmer's Lung

Search GEO for disease gene expression data for Farmer's Lung.

Pathways for Farmer's Lung

Pathways related to Farmer's Lung according to GeneCards Suite gene sharing:

(show all 20)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 CD36 CD40LG CD79A ELANE IL2 PI3
2
Show member pathways
12.26 CD40LG CD79A IL2 TNF
3 12.12 CD40LG CD79A IL2 TNF
4
Show member pathways
12.11 CD40LG IL2 TNF
5
Show member pathways
11.43 CD40LG IL2 TNF
6 11.3 IL2 TNF
7 11.28 CD36 CD40LG TNF
8 11.27 ELANE TNF
9 11.26 CD36 TNF
10 11.25 IL2 TNF
11
Show member pathways
11.16 IL2 TNF
12
Show member pathways
11.13 CD40LG IL2 TNF
13 11.12 CD40LG CD79A
14 11.08 CD36 CD40LG
15 11.03 CD40LG IL2
16 10.99 CD36 CD79A IL2 TNF
17 10.97 IL2 TNF
18 10.88 CD40LG IL2 TNF
19 10.82 CD36 CD40LG TNF
20 10.66 CD36 TNF

GO Terms for Farmer's Lung

Cellular components related to Farmer's Lung according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 CD36 CD40LG ELANE IL2 TNF
2 membrane raft GO:0045121 9.43 CD36 CD79A TNF
3 cell surface GO:0009986 9.26 CD36 CD40LG ELANE TNF
4 external side of plasma membrane GO:0009897 8.92 CD36 CD40LG CD79A TNF

Biological processes related to Farmer's Lung according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.62 CD36 CD40LG IL2 TNF
2 positive regulation of interferon-gamma production GO:0032729 9.46 IL2 TNF
3 positive regulation of interleukin-6 production GO:0032755 9.43 CD36 TNF
4 B cell proliferation GO:0042100 9.4 CD40LG CD79A
5 positive regulation of interleukin-12 production GO:0032735 9.37 CD36 CD40LG
6 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.26 ELANE TNF
7 regulation of immunoglobulin secretion GO:0051023 9.16 CD40LG TNF
8 positive regulation of blood microparticle formation GO:2000334 8.96 CD36 TNF
9 negative regulation of growth of symbiont in host GO:0044130 8.8 CD36 ELANE TNF

Molecular functions related to Farmer's Lung according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.96 CD40LG TNF
2 cytokine activity GO:0005125 8.8 CD40LG IL2 TNF

Sources for Farmer's Lung

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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