MCID: FRM003
MIFTS: 51

Farmer's Lung malady

Respiratory diseases, Immune diseases categories

Summaries for Farmer's Lung

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An extrinsic allergic alveolitis which is induced by the inhalation of spores (aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. it is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

MalaCards: Farmer's Lung, also known as farmers lung, is related to extrinsic allergic alveolitis and nephrotic syndrome. An important gene associated with Farmer's Lung is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Inflammatory Response Pathway and IL12 signaling mediated by STAT4. The compounds pirfenidone and pge2 have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and skin, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Farmer's Lung

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 10DISEASES, 44Novoseek, 48Orphanet, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Immune diseases


Aliases & Descriptions:

farmer's lung 8 42 60
farmers lung 8 10 44
farmer's lung disease 48
farmers' lung 8


External Ids:

Disease Ontology8 DOID:14453
NCIt39 C34605
ICD9CM27 495.0
MeSH34 D005203
ICD10 via Orphanet26 J67.0
SNOMED-CT via Orphanet57 18690003
UMLS via Orphanet61 C0015634
MESH via Orphanet35 D005203
ICD1025 J67.0

Related Diseases for Farmer's Lung

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Farmer's Lung:



Diseases related to farmer's lung

Clinical Features for Farmer's Lung

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Drugs & Therapeutics for Farmer's Lung

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Farmer's Lung

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Genetic Tests for Farmer's Lung

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Anatomical Context for Farmer's Lung

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Sources:
32MalaCards
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MalaCards organs/tissues related to Farmer's Lung:

32
Lung, Testes, Skin, B cells

Animal Models for Farmer's Lung or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Farmer's Lung:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6IGHE, CD36, IL2RA, IL2, SLPI, TNF
2MP:00053977.3SLPI, IL2, IL2RA, CD36, IGHE, TNF

Publications for Farmer's Lung

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Sources:
50PubMed
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Articles related to Farmer's Lung:

(show top 50)    (show all 331)
idTitleAuthorsYear
1
Farmer's lung in a case after bullectomy. (22398814)
2012
2
Microbiological evolution of hay and relapse in patients with farmer's lung. (14691284)
2004
3
Tumor necrosis factor-alpha -308 promoter gene polymorphism and increased tumor necrosis factor serum bioactivity in farmer's lung patients. (11179110)
2001
4
Asthma in patients with farmer's lung during a five-year follow-up. (9167238)
1997
5
Mortality due to farmer's lung in Finland. (7774328)
1994
6
Mast cell and histamine involvement in farmer's lung disease. (8162747)
1994
7
Monoclonal antibodies against farmer's lung antigens having specific binding to IgG antibodies. (8400887)
1993
8
Prevalence and risk factors for chronic bronchitis and farmer's lung in French dairy farmers. (8217855)
1993
9
Farmer's fever. Systemic manifestation of farmer's lung without lung involvement. (8432174)
1993
10
Class specific antibodies in serodiagnosis of farmer's lung. (1599871)
1992
11
Changes in the titers of IgG antibodies against farmer's lung antigens in the sera of healthy dairy farmers. (2337263)
1990
12
Dot-immunobinding assay in the detection of IgG antibodies against farmer's lung antigens. (3140016)
1988
13
Protective value of powered dust respirator helmet for farmers with farmer's lung. (3478219)
1987
14
IgG subclasses in farmer's lung. (3480825)
1987
15
Farmer's lung--a 5-year follow-up of eighty-six patients. (3581462)
1987
16
Enzyme-linked immunofiltration assay (ELIFA) for the detection of specific antibodies (IgG-IgM-IgA-IgE) in farmer's lung disease. (2431808)
1986
17
Farmer's lung presenting as respiratory failure and homogeneous consolidation. (3769592)
1986
18
Farmer's lung in a 10-year-old boy. (3866989)
1985
19
Death certification of farmer's lung and chronic airway diseases in different countries of the EEC. (4052307)
1985
20
Clinical aspects of farmer's lung: airway reactivity, treatment and prognosis. (6426996)
1984
21
Ten year follow up of farmers with farmer's lung. (6830713)
1983
22
Farmer's lung disease: an evaluation of health education in the North-West of Ireland. (7174248)
1982
23
Precipitating antibodies to farmer's lung antigens in a Wisconsin farming population. (7027852)
1981
24
Serologically detectable HLA-A, B, and C loci antigens in farmer's lung disease. (7416619)
1980
25
Farmer's lung disease and coeliac disease: a prospective study. (591277)
1977
26
Farmer's lung: immunological response to a group of extracellular enzymes of Micropolyspora faeni. An experimental and field study. (862229)
1977
27
Antibodies of different immunoglobulin classes against antigens causing farmer's lung. (823846)
1976
28
Letter: Farmer's lung: a neglected antigen. (57352)
1976
29
Letter: Farmer's lung. (1156834)
1975
30
Fog fever, farmer's lung and diffuse fibrosing alveolitis in cattle. (1121747)
1975
31
A simplified hemagglutination test for farmer's lung. (4621608)
1972
32
Experimental farmer's lung in guinea-pigs. (5129754)
1971
33
Roentgen findings in farmer's lung. (5481139)
1970
34
Influence of various parameters on the sensitivity of precipitin tests in farmer's lung by immunodiffusion and immunoosmophoresis. (4983352)
1969
35
Immunofluorescence Identification of Thermopolyspora polyspora, the Causative Agent of Farmer's Lung. (16349854)
1969
36
Farmer's lung. (5822950)
1969
37
Immunofluorescence identification of Thermopolyspora polyspora, the causative agent of farmer's lung. (4976327)
1969
38
Farmer's Lung. (5764528)
1969
39
Rapid and sensitive precipitin test for the diagnosis of farmer's lung using immunoosmophoresis. (4972436)
1968
40
Farmer's lung. (6075681)
1967
41
Farmer's lung. A case report from Ceylon. (6035949)
1967
42
PRECIPITIN (F.L.H.) TEST IN FARMER'S LUNG. (14255481)
1965
43
Inhalation and skin tests with extracts of hay and fungi in patients with farmer's lung. (14000894)
1963
44
PULMONARY FUNCTION STUDIES IN PATIENTS WITH FARMER'S LUNG. (14064620)
1963
45
RESPIRATORY DISTRESS IN SOME DISEASES OF MAN AND ANIMALS. EPIDEMIOLOGICAL OBSERVATIONS ON FARMER'S LUNG. (14084410)
1963
46
Farmer's lung. (13895857)
1962
47
Farmer's lung; a form of pneumoconiosis due to organic dusts. (13498211)
1958
48
FARMER'S lung. (13546663)
1958
49
Farmer's lung. (13042230)
1953
50
FARMER'S lung. (13045463)
1953

Genetic Variations for Farmer's Lung

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Expression for genes affiliated with Farmer's Lung

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Farmer's Lung

Search GEO for disease gene expression data for Farmer's Lung.

Pathways for genes affiliated with Farmer's Lung

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Farmer's Lung

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Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB, 24HMDB
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Compounds related to Farmer's Lung according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1pirfenidone44 5911.5CD36
2pge24410.5IL2
3mizoribine4410.1IL2RA, IL2
4denileukin diftitox44 49 1112.0IL2, IL2RA
5interferon gamma449.9TNF, IL2
6pentostatin44 59 28 1112.9IL2, IL2RA
7benzylpenicillin449.8IL2, IGHE
8piclamilast44 1110.8IL2, TNF
9c-d4t449.7IL2, IL2RA
10mycophenolate mofetil44 49 1111.7IL2, IL2RA, CD36
11gold sodium thiomalate449.7IL2RA, IL2, TNF
12okt3449.7IL2RA, IL2, TNF
132,5-oligoadenylate449.7IL2RA, IL2, TNF
14il 10449.7IL2RA, IL2, TNF
15mycophenolic acid44 49 1111.6IL2, IL2RA, IGHE
16neopterin449.6IL2, IL2RA, TNF
17taurine chloramine449.6TNF, IL2
18rituximab44 49 1111.6IL2, TNF, IL2RA
19hydrocortisone44 2 59 1112.6IGHE, SLPI
20chloroquine44 2 49 28 1113.6TNF, IL2RA, IL2
21infliximab44 49 1111.5TNF, IGHE, IL2RA
22ivig449.5TNF, IL2RA, IGHE
23budesonide44 49 1111.5TNF, CD36, IGHE
24etidronate449.5CD36, SLPI
25lamivudine44 1110.4IL2RA, SLPI, CD36
26thalidomide44 49 59 1112.4IL2, TNF, CD36, IL2RA
27alizarin449.3SLPI, CD36
2825-hydroxyvitamin d449.3SLPI, IL2RA, CD36
29herbimycin a44 5910.3IL2, CD36, TNF, IL2RA
30tacrolimus44 49 1111.3CD36, TNF, IL2, IL2RA
31lenalidomide44 1110.3IL2, TNF
32zoledronic acid449.3IL2, SLPI, CD36
33mifepristone44 59 28 1112.2PI3, IL2RA, SLPI
34prednisolone44 28 1111.2IL2RA, IGHE, IL2, TNF
35azathioprine44 49 2 1112.1IL2, IL2RA, SLPI
36fluticasone propionate44 49 59 1112.1IGHE, SLPI, TNF
37levamisole44 119.9SLPI, IL2, IL2RA, IGHE
38rantes448.8SLPI, IL2, IL2RA, TNF
39ascorbic acid44 249.8SLPI, CD36, IGHE, IL2RA
40vitamin d448.8IL2RA, SLPI, IGHE, CD36
41actinomycin d448.5TNF, IGHE, IL2, SLPI
42calcitriol44 59 11 2411.5SLPI, IL2RA, TNF, IL2, CD36
43genistein44 28 59 2 11 2413.5SLPI, TNF, IL2, IL2RA, CD36
44thymidine44 249.4IL2, SLPI, TNF, IL2RA
45cycloheximide448.3IGHE, CD36, SLPI, IL2, TNF
46retinoic acid44 249.1CD36, IGHE, PI3, TNF, SLPI
47histamine44 28 2410.0SLPI, IL2, IL2RA, IGHE, PI3, TNF
48cyclosporin a44 28 5910.0IGHE, IL2RA, PI3, TNF, SLPI, IL2
49vegf448.0IL2, SLPI, CD36, IGHE, TNF, IL2RA
50dexamethasone44 49 28 1110.7CD36, IGHE, PI3, TNF, IL2, IL2RA

GO Terms for genes affiliated with Farmer's Lung

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Sources:
16Gene Ontology
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Cellular components related to Farmer's Lung according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL2RA, CD36, TNF

Biological processes related to Farmer's Lung according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell homeostatic proliferationGO:0460139.9IL2, IL2RA
2positive regulation of activated T cell proliferationGO:0421049.8IL2, IL2RA
3negative regulation of growth of symbiont in hostGO:0441309.8CD36, TNF
4positive regulation of interleukin-6 productionGO:0327559.6CD36, TNF
5positive regulation of interferon-gamma productionGO:0327299.5IL2, TNF
6defense response to Gram-positive bacteriumGO:0508309.3CD36, TNF
7negative regulation of viral genome replicationGO:0450719.2TNF, SLPI

Molecular functions related to Farmer's Lung according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.3SLPI, PI3

Products for genes affiliated with Farmer's Lung

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  • Antibodies
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  • Antibodies

Sources for Farmer's Lung

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet