MCID: FRM003
MIFTS: 54

Farmer's Lung malady

Rare diseases, Respiratory diseases, Immune diseases categories
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Summaries for Farmer's Lung

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Disease Ontology:8 An extrinsic allergic alveolitis which is induced by the inhalation of spores (aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. it is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

MalaCards based summary: Farmer's Lung, also known as farmers lung, is related to extrinsic allergic alveolitis and erysipelas. An important gene associated with Farmer's Lung is PI3 (peptidase inhibitor 3, skin-derived), and among its related pathways are Inflammatory Response Pathway and IL2-mediated signaling events. The compounds mizoribine and denileukin diftitox have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and skin, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Aliases & Classifications for Farmer's Lung

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 62UMLS, 10DISEASES, 44Novoseek, 48Orphanet, 57SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Farmer's Lung, Aliases & Descriptions:

Name: Farmer's Lung 8 42 62
Farmers Lung 8 10 44
 
Farmer's Lung Disease 48 62
Farmer Lung 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases, Immune diseases


External Ids:

Disease Ontology8 DOID:14453
NCIt39 C34605
ICD9CM27 495.0
MeSH34 D005203
MESH via Orphanet35 D005203
ICD10 via Orphanet26 J67.0
UMLS via Orphanet63 C0015634
ICD1025 J67.0

Related Diseases for Farmer's Lung

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Diseases related to Farmer's Lung via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1extrinsic allergic alveolitis30.6PI3, IL2RA
2erysipelas10.5PI3
3trichomoniasis10.5SLPI
4periapical granuloma10.5IL2RA
5netherton syndrome10.4IGHE
6sinusitis10.4IGHE
7ulcerative colitis10.4TNF
8leprosy10.3IL2
9splenomegaly10.3SLPI, IL2RA
10bronchiectasis10.2IGHE, SLPI
11bronchitis10.2IGHE, SLPI
12hypereosinophilic syndrome10.2IL2RA, IGHE
13adult respiratory distress syndrome10.2PI3, TNF
14hepatitis b10.2SLPI, IL2RA
15mastocytosis10.2IL2RA, IGHE
16renal osteodystrophy10.2CD36, SLPI
17localized scleroderma10.2IL2RA, CD36
18secondary hyperparathyroidism of renal origin10.2SLPI, CD36
19juvenile rheumatoid arthritis10.2IL2RA, TNF
20behcet's disease10.2TNF, IL2RA
21osteomalacia10.2CD36, SLPI
22rickets10.2SLPI, CD36
23peritonitis10.2TNF, SLPI
24vernal keratoconjunctivitis10.2CD36, IGHE
25malaria10.2TNF, CD36
26cerebral malaria10.1TNF, CD36
27tropical spastic paraparesis10.1IL2, IL2RA
28rheumatic disease10.1TNF, IL2RA
29chronic obstructive pulmonary disease10.1PI3, TNF, SLPI
30sezary's disease10.1IL2, IL2RA
31pneumonia10.1PI3, TNF, SLPI
32gamma chain deficiency10.1IL2RA, IL2
33uveitis10.1IL2RA, TNF
34diabetes mellitus10.1CD36, TNF
35common variable immunodeficiency10.1IL2, IL2RA
36hairy cell leukemia10.1IL2, IL2RA
37toxic shock syndrome10.1IL2, TNF
38pulmonary tuberculosis10.1IL2, IL2RA
39skin disease10.0TNF, IGHE, PI3
40mycosis fungoides10.0IL2RA, IL2
41lymphopenia10.0IL2, IL2RA
42cork-handlers' disease10.0IL2, SLPI
43secondary syphilis10.0CD36, SLPI
44cutaneous t cell lymphoma10.0IL2, IL2RA
45periodontitis10.0TNF, CD36, SLPI
46periodontal disease10.0CD36, TNF, SLPI
47severe combined immunodeficiency10.0IL2, IL2RA
48osteoarthritis10.0TNF, CD36, SLPI
49diphtheria9.9IL2RA, IL2
50tetanus9.9IL2, IL2RA

Graphical network of the top 20 diseases related to Farmer's Lung:



Diseases related to farmer's lung

Symptoms for Farmer's Lung

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Drugs & Therapeutics for Farmer's Lung

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Drug clinical trials:

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Search NIH Clinical Center for Farmer's Lung

Genetic Tests for Farmer's Lung

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Anatomical Context for Farmer's Lung

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MalaCards organs/tissues related to Farmer's Lung:

32
Lung, Testes, Skin, B cells, Neutrophil

Animal Models for Farmer's Lung or affiliated genes

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MGI Mouse Phenotypes related to Farmer's Lung:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.2TNF, IL2, IL2RA, CD36
2MP:00053767.5SLPI, CD36, IL2, TNF, IGHE
3MP:00053977.1SLPI, CD36, IL2RA, IL2, TNF, IGHE
4MP:00053877.0IGHE, TNF, IL2, IL2RA, CD36, SLPI

Publications for Farmer's Lung

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Articles related to Farmer's Lung:

(show top 50)    (show all 331)
idTitleAuthorsYear
1
Immunoreactive proteins of Saccharopolyspora rectivirgula for farmer's lung serodiagnosis. (25264606)
2014
2
Pesticides and other agricultural factors associated with self-reported farmer's lung among farm residents in the Agricultural Health Study. (17182642)
2007
3
Farmer's lung is now in decline. (16986564)
2006
4
Farmer's lung disease and microbiological composition of hay: a case-control study. (16244894)
2005
5
Evaluation of salting as a hay preservative against farmer's lung disease agents. (16457476)
2005
6
Farmer's lung. (15529581)
2003
7
Tumor necrosis factor-alpha -308 promoter gene polymorphism and increased tumor necrosis factor serum bioactivity in farmer's lung patients. (11179110)
2001
8
High-resolution computed tomographic characteristics in acute farmer's lung and in its follow-up. (10933085)
2000
9
Saccharopolyspora rectivirgula from Quebec dairy barns: application of simplified criteria for the identification of an agent responsible for farmer's lung disease. (9989646)
1999
10
Long-term outcome of pulmonary function in farmer's lung: a 14 year follow-up with matched controls. (9311500)
1997
11
Farmer's lung: patients' IgG2 antibodies specifically recognize Saccharopolyspora rectivirgula proteins and carbohydrate structures. (8757222)
1996
12
Farmer's lung and variables related to the decision to quit farming. (7663816)
1995
13
Mortality due to farmer's lung in Finland. (7774328)
1994
14
Monoclonal antibodies against farmer's lung antigens having specific binding to IgG antibodies. (8400887)
1993
15
Comparison of methods of production of farmer's lung antigens. (1282842)
1992
16
Farmer's lung in infants and small children. (2719181)
1989
17
Bronchoalveolar mastocytosis in farmer's lung is related to the disease activity. (3377620)
1988
18
Epidemiological study of farmer's lung in five districts of the French Doubs province. (3420554)
1988
19
Protective value of powered dust respirator helmet for farmers with farmer's lung. (3478219)
1987
20
Prevalence of serum precipitins against microbes in mouldy hay, and of chronic bronchitis and farmer's lung with respect to farmers' occupational health hazards. (3478212)
1987
21
Prognostic significance of bronchoalveolar lymphocytosis in farmer's lung. (3826894)
1987
22
Farmer's lung after Mycoplasma pneumoniae infection. (3704970)
1986
23
Enzyme-linked immunofiltration assay (ELIFA) for the detection of specific antibodies (IgG-IgM-IgA-IgE) in farmer's lung disease. (2431808)
1986
24
Farmer's lung in a 10-year-old boy. (3866989)
1985
25
Immunohistochemical identification of Aspergillus fumigatus in farmer's lung. (6441428)
1984
26
Importance of anti-lung antibody in farmer's lung disease. (6837583)
1983
27
Antigenic determinants on B cells of farmer's lung patients. (6180923)
1982
28
Farmer's lung disease in Vermont. (375344)
1979
29
Farmer's lung disease among farmers with precipitating antibodies to the thermophilic actinomycetes: a clinical and immunologic study. (681631)
1978
30
The use of antigens grown at different temperatures in the diagnosis of Farmer's lung disease. (651569)
1978
31
Antibodies of different immunoglobulin classes against antigens causing farmer's lung. (823846)
1976
32
Letter: Farmer's lung: a neglected antigen. (57352)
1976
33
Farmer's lung. (4846024)
1974
34
A bovine disease similar to farmer's lung: extrinsic allergic alveolitis. (4252199)
1971
35
Farmer's lung--an acute or chronic disease? (5273209)
1970
36
Farmer's Lung in Urbanites. (20468586)
1970
37
Farmer's lung. (4976124)
1969
38
The pathology of the acute and chronic stages of farmer's lung. (5680234)
1968
39
Farmer's lung. (5253275)
1968
40
Farmer's lung: a study of an early acute fatal case. (4234473)
1968
41
Farmer's lung. (6075681)
1967
42
Farmer's lung as observed in chest survey clinics. (5215338)
1965
43
Farmer's lung scheduled as a prescribed occupational disease in Great Britain. (5831722)
1965
44
Farmer's lung. Report of a case, with lung biopsy. (13941062)
1963
45
Antigens in moldy hay as the cause of farmer's lung. (14033919)
1963
46
A Survey of " Farmer's Lung ". (19790385)
1961
47
Farmer's lung: a case report. (13881136)
1961
48
A syndrome resembling farmer's lung in workers inhaling spores of Aspergillus and Penicillia moulds. (13715832)
1960
49
Farmer's lung; a form of pneumoconiosis due to organic dusts. (13498211)
1958
50
A case of farmer's lung. (14913703)
1952

Variations for Farmer's Lung

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Expression for genes affiliated with Farmer's Lung

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Expression patterns in normal tissues for genes affiliated with Farmer's Lung

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Pathways for genes affiliated with Farmer's Lung

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Pathways related to Farmer's Lung according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL2RA, IL2
2
Show member pathways
IL-2 Signaling pathway37
9.5IL2RA, IL2
39.5IL2, IL2RA
4
Show member pathways
Immune response IL 3 activation and signaling pathway60
9.5IL2RA, IL2
5
Show member pathways
9.5IL2RA, IL2
6
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.5IL2RA, IL2
7
Show member pathways
IL2 signaling events mediated by STAT537
9.5IL2RA, IL2
89.4TNF, CD36
99.4CD36, TNF
109.4TNF, CD36
11
Show member pathways
IL27-mediated signaling events37
9.3IL2, TNF
129.3TNF, IL2
13
Show member pathways
AhR pathway37
9.3IL2, TNF
149.3TNF, IL2
159.3IL2, TNF
169.0TNF, IL2RA, CD36
17
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.9IL2RA, IL2, TNF
18
Show member pathways
8.9IL2RA, IL2, TNF
19
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.9IL2RA, IL2, TNF
20
Show member pathways
8.9IL2RA, IL2, TNF
21
Show member pathways
8.9IL2RA, IL2, TNF
22
Show member pathways
8.9IL2RA, IL2, TNF
238.9IL2RA, IL2, TNF
24
Show member pathways
8.9IL2RA, IL2, TNF
25
Show member pathways
8.9TNF, IL2, IL2RA
26
Show member pathways
Ras signaling in the CD4+ TCR pathway37
8.9TNF, IL2, IL2RA
27
Show member pathways
8.9TNF, IL2, IL2RA

Compounds for genes affiliated with Farmer's Lung

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Compounds related to Farmer's Lung according to GeneCards/GeneDecks:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1mizoribine449.8IL2, IL2RA
2denileukin diftitox44 50 1111.6IL2RA, IL2
3pirfenidone44 6110.5IL2, CD36, IL2RA
4benzylpenicillin449.4IGHE, IL2
5mycophenolic acid44 50 1111.4IL2, IL2RA, IGHE
6gold sodium thiomalate449.3TNF, IL2, IL2RA
7piclamilast44 1110.3TNF, IL2
8okt3449.3TNF, IL2RA, IL2
92,5-oligoadenylate449.3IL2, TNF, IL2RA
10il 10449.3IL2RA, TNF, IL2
11budesonide44 50 1111.3IGHE, TNF, CD36
12infliximab44 50 1111.3TNF, IL2RA, IGHE
13ivig449.2TNF, IL2RA, IGHE
14pentoxifylline44 1110.2IL2, IL2RA, TNF
15interferon gamma449.2IL2, TNF
16glucosamine44 24 1111.2CD36, IL2, TNF
17neopterin449.2IL2, IL2RA, TNF
18rituximab44 50 1111.2IL2RA, IL2, TNF
19lamivudine44 50 1111.2SLPI, CD36, IL2RA
20chloroquine44 2 50 28 1113.2IL2, TNF, IL2RA
2125-hydroxyvitamin d449.2CD36, IL2RA, SLPI
22zoledronic acid449.1SLPI, IL2, CD36
23mifepristone44 28 61 1112.1PI3, IL2RA, SLPI
24mycophenolate mofetil44 50 1110.9IL2RA, IL2, TNF, CD36
25azathioprine44 2 50 1111.9IL2, IL2RA, SLPI
26thalidomide44 50 61 1111.9TNF, IL2, IL2RA, CD36
27etidronate448.9CD36, SLPI
28fluticasone propionate44 50 61 1111.9IGHE, SLPI, TNF
29herbimycin a44 619.9TNF, IL2RA, CD36, IL2
30tacrolimus44 50 1110.9TNF, IL2, IL2RA, CD36
31prednisolone44 28 1110.8IGHE, IL2RA, TNF, IL2
32indomethacin44 28 61 1111.8IGHE, IL2RA, IL2, TNF
33levamisole44 119.6SLPI, IL2RA, IL2, IGHE
34ascorbic acid44 249.6CD36, IL2RA, SLPI, IGHE
35vitamin d448.6SLPI, CD36, IL2RA, IGHE
36rantes448.5IL2, TNF, IL2RA, SLPI
37creatinine448.4IL2RA, IGHE, CD36, SLPI
38heparin44 28 24 1111.4CD36, IL2RA, IGHE, SLPI
39thymidine44 249.3SLPI, IL2RA, TNF, IL2
40actinomycin d448.3IGHE, TNF, IL2, SLPI
41calcitriol44 61 24 1111.1TNF, IL2, IL2RA, CD36, SLPI
42genistein44 28 61 2 24 1113.1IL2, SLPI, CD36, IL2RA, TNF
43pge2448.1IL2RA, SLPI, CD36, IL2, TNF
44retinoic acid44 249.0TNF, IGHE, CD36, SLPI, PI3
45hydrocortisone44 2 61 1111.0SLPI, IL2, IGHE, CD36, TNF
46cycloheximide447.9IGHE, SLPI, CD36, IL2, TNF
47histamine44 28 249.7PI3, SLPI, IL2RA, TNF, IGHE, IL2
48cyclosporin a44 28 619.6TNF, IL2, IL2RA, SLPI, IGHE, PI3
49vegf447.6IL2RA, CD36, IGHE, TNF, IL2, SLPI
50dexamethasone44 50 28 1110.2IL2, SLPI, IL2RA, IGHE, PI3, TNF

GO Terms for genes affiliated with Farmer's Lung

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Cellular components related to Farmer's Lung according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0CD36, IL2RA, TNF

Biological processes related to Farmer's Lung according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell homeostatic proliferationGO:0460139.8IL2RA, IL2
2positive regulation of activated T cell proliferationGO:0421049.7IL2, IL2RA
3negative regulation of growth of symbiont in hostGO:0441309.6CD36, TNF
4defense response to Gram-positive bacteriumGO:0508309.5CD36, TNF
5positive regulation of interferon-gamma productionGO:0327299.4TNF, IL2
6positive regulation of interleukin-6 productionGO:0327559.3TNF, CD36
7negative regulation of endopeptidase activityGO:0109519.3SLPI, PI3
8negative regulation of inflammatory responseGO:0507289.2IL2RA, IL2
9negative regulation of viral genome replicationGO:0450719.2SLPI, TNF
10immune responseGO:0069559.0IL2RA, IL2, IGHE

Molecular functions related to Farmer's Lung according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.3SLPI, PI3

Products for genes affiliated with Farmer's Lung

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Sources for Farmer's Lung

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet