MCID: FRM003
MIFTS: 53

Farmer's Lung malady

Rare diseases, Respiratory diseases, Immune diseases categories
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Summaries for Farmer's Lung

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 An extrinsic allergic alveolitis which is induced by the inhalation of spores (aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. it is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

MalaCards: Farmer's Lung, also known as farmers lung, is related to extrinsic allergic alveolitis and erysipelas. An important gene associated with Farmer's Lung is PI3 (peptidase inhibitor 3, skin-derived), and among its related pathways are Inflammatory Response Pathway and IL2-mediated signaling events. The compounds mizoribine and denileukin diftitox have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and skin, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Aliases & Classifications for Farmer's Lung

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 36MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases, Immune diseases


Aliases & Descriptions:

farmer's lung 8 43 62
farmers lung 8 10 45
farmer's lung disease 49
farmer lung 8


External Ids:

Disease Ontology8 DOID:14453
MeSH35 D005203
ICD9CM27 495.0
NCIt40 C34605
ICD10 via Orphanet26 J67.0
SNOMED-CT via Orphanet59 18690003
UMLS via Orphanet63 C0015634
MESH via Orphanet36 D005203
ICD1025 J67.0

Related Diseases for Farmer's Lung

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Farmer's Lung via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1extrinsic allergic alveolitis30.4PI3, IL2RA
2erysipelas10.1PI3
3trichomoniasis10.1SLPI
4periapical granuloma10.1IL2RA
5netherton syndrome10.1IGHE
6sinusitis10.1IGHE
7ulcerative colitis10.1TNF
8leprosy10.1IL2
9newborn respiratory distress syndrome10.1SLPI, PI3
10splenomegaly10.1SLPI, IL2RA
11bronchiectasis10.1IGHE, SLPI
12bronchitis10.1IGHE, SLPI
13hypereosinophilic syndrome10.1IL2RA, IGHE
14adult respiratory distress syndrome10.1PI3, TNF
15hepatitis b10.1SLPI, IL2RA
16mastocytosis10.1IL2RA, IGHE
17renal osteodystrophy10.0CD36, SLPI
18localized scleroderma10.0IL2RA, CD36
19secondary hyperparathyroidism of renal origin10.0SLPI, CD36
20juvenile rheumatoid arthritis10.0IL2RA, TNF
21behcet's disease10.0TNF, IL2RA
22osteomalacia10.0CD36, SLPI
23rickets10.0SLPI, CD36
24peritonitis10.0TNF, SLPI
25vernal keratoconjunctivitis10.0CD36, IGHE
26malaria10.0TNF, CD36
27cerebral malaria10.0TNF, CD36
28rheumatic disease10.0TNF, IL2RA
29tropical spastic paraparesis10.0IL2, IL2RA
30uveitis10.0IL2RA, TNF
31pulmonary disease, chronic obstructive10.0PI3, TNF, SLPI
32immunodeficiency, common variable, 710.0IL2RA, IL2
33sezary's disease10.0IL2, IL2RA
34pneumonia10.0PI3, TNF, SLPI
35gamma chain deficiency10.0IL2RA, IL2
36diabetes mellitus10.0CD36, TNF
37common variable immune deficiency10.0IL2, IL2RA
38hairy cell leukemia10.0IL2, IL2RA
39toxic shock syndrome10.0IL2, TNF
40pulmonary tuberculosis10.0IL2, IL2RA
41skin disease10.0TNF, IGHE, PI3
42secondary syphilis10.0CD36, SLPI
43mycosis fungoides10.0IL2RA, IL2
44lymphopenia10.0IL2, IL2RA
45cork-handlers' disease10.0IL2, SLPI
46cutaneous t cell lymphoma10.0IL2, IL2RA
47periodontitis10.0TNF, CD36, SLPI
48periodontal disease10.0CD36, TNF, SLPI
49severe combined immunodeficiency10.0IL2, IL2RA
50diphtheria10.0IL2RA, IL2

Graphical network of the top 20 diseases related to Farmer's Lung:



Diseases related to farmer's lung

Symptoms for Farmer's Lung

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Drugs & Therapeutics for Farmer's Lung

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Farmer's Lung

Search NIH Clinical Center for Farmer's Lung

Genetic Tests for Farmer's Lung

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Anatomical Context for Farmer's Lung

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Sources:
33MalaCards
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MalaCards organs/tissues related to Farmer's Lung:

33
Lung, Testes, Skin, B cells

Animal Models for Farmer's Lung or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Farmer's Lung:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.2TNF, IL2, IL2RA, CD36
2MP:00053767.5SLPI, CD36, IL2, TNF, IGHE
3MP:00053977.1SLPI, CD36, IL2RA, IL2, TNF, IGHE
4MP:00053877.0IGHE, TNF, IL2, IL2RA, CD36, SLPI

Publications for Farmer's Lung

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Sources:
52PubMed
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Articles related to Farmer's Lung:

(show top 50)    (show all 329)
idTitleAuthorsYear
1
Pesticides and other agricultural factors associated with self-reported farmer's lung among farm residents in the Agricultural Health Study. (17182642)
2007
2
Farmer's lung is now in decline. (16986564)
2006
3
Farmer's lung disease and microbiological composition of hay: a case-control study. (16244894)
2005
4
Evaluation of salting as a hay preservative against farmer's lung disease agents. (16457476)
2005
5
Farmer's lung. (15529581)
2003
6
Tumor necrosis factor-alpha -308 promoter gene polymorphism and increased tumor necrosis factor serum bioactivity in farmer's lung patients. (11179110)
2001
7
High-resolution computed tomographic characteristics in acute farmer's lung and in its follow-up. (10933085)
2000
8
Saccharopolyspora rectivirgula from Quebec dairy barns: application of simplified criteria for the identification of an agent responsible for farmer's lung disease. (9989646)
1999
9
Long-term outcome of pulmonary function in farmer's lung: a 14 year follow-up with matched controls. (9311500)
1997
10
Farmer's lung: patients' IgG2 antibodies specifically recognize Saccharopolyspora rectivirgula proteins and carbohydrate structures. (8757222)
1996
11
Farmer's lung and variables related to the decision to quit farming. (7663816)
1995
12
Mortality due to farmer's lung in Finland. (7774328)
1994
13
Monoclonal antibodies against farmer's lung antigens having specific binding to IgG antibodies. (8400887)
1993
14
Comparison of methods of production of farmer's lung antigens. (1282842)
1992
15
Farmer's lung in infants and small children. (2719181)
1989
16
Bronchoalveolar mastocytosis in farmer's lung is related to the disease activity. (3377620)
1988
17
Epidemiological study of farmer's lung in five districts of the French Doubs province. (3420554)
1988
18
Protective value of powered dust respirator helmet for farmers with farmer's lung. (3478219)
1987
19
Prevalence of serum precipitins against microbes in mouldy hay, and of chronic bronchitis and farmer's lung with respect to farmers' occupational health hazards. (3478212)
1987
20
Prognostic significance of bronchoalveolar lymphocytosis in farmer's lung. (3826894)
1987
21
IgG subclasses in farmer's lung. (3480825)
1987
22
Farmer's lung after Mycoplasma pneumoniae infection. (3704970)
1986
23
Enzyme-linked immunofiltration assay (ELIFA) for the detection of specific antibodies (IgG-IgM-IgA-IgE) in farmer's lung disease. (2431808)
1986
24
Farmer's lung in a 10-year-old boy. (3866989)
1985
25
Immunohistochemical identification of Aspergillus fumigatus in farmer's lung. (6441428)
1984
26
Importance of anti-lung antibody in farmer's lung disease. (6837583)
1983
27
Antigenic determinants on B cells of farmer's lung patients. (6180923)
1982
28
Farmer's lung disease in Vermont. (375344)
1979
29
Farmer's lung disease among farmers with precipitating antibodies to the thermophilic actinomycetes: a clinical and immunologic study. (681631)
1978
30
The use of antigens grown at different temperatures in the diagnosis of Farmer's lung disease. (651569)
1978
31
Antibodies of different immunoglobulin classes against antigens causing farmer's lung. (823846)
1976
32
Letter: Farmer's lung: a neglected antigen. (57352)
1976
33
Farmer's lung. (4846024)
1974
34
A bovine disease similar to farmer's lung: extrinsic allergic alveolitis. (4252199)
1971
35
Farmer's lung--an acute or chronic disease? (5273209)
1970
36
Farmer's Lung in Urbanites. (20468586)
1970
37
Farmer's lung. (4976124)
1969
38
The pathology of the acute and chronic stages of farmer's lung. (5680234)
1968
39
Farmer's lung. (5253275)
1968
40
Farmer's lung: a study of an early acute fatal case. (4234473)
1968
41
Farmer's lung. (6075681)
1967
42
Farmer's lung as observed in chest survey clinics. (5215338)
1965
43
Farmer's lung scheduled as a prescribed occupational disease in Great Britain. (5831722)
1965
44
Farmer's lung. Report of a case, with lung biopsy. (13941062)
1963
45
Antigens in moldy hay as the cause of farmer's lung. (14033919)
1963
46
A Survey of " Farmer's Lung ". (19790385)
1961
47
Farmer's lung: a case report. (13881136)
1961
48
A syndrome resembling farmer's lung in workers inhaling spores of Aspergillus and Penicillia moulds. (13715832)
1960
49
Farmer's lung; a form of pneumoconiosis due to organic dusts. (13498211)
1958
50
A case of farmer's lung. (14913703)
1952

Variations for Farmer's Lung

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Expression for genes affiliated with Farmer's Lung

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Farmer's Lung

Search GEO for disease gene expression data for Farmer's Lung.

Pathways for genes affiliated with Farmer's Lung

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Sources:
50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 61Tocris Bioscience, 30KEGG, 53QIAGEN, 54R&D Systems
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Pathways related to Farmer's Lung according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL2RA, IL2
2
Show member pathways
IL-2 Signaling pathway38
9.5IL2RA, IL2
39.5IL2, IL2RA
4
Show member pathways
Immune response IL 3 activation and signaling pathway60
9.5IL2RA, IL2
5
Show member pathways
9.5IL2RA, IL2
6
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.5IL2RA, IL2
7
Show member pathways
IL2 signaling events mediated by STAT538
9.5IL2RA, IL2
89.4TNF, CD36
99.4CD36, TNF
109.4TNF, CD36
11
Show member pathways
IL27-mediated signaling events38
9.3IL2, TNF
129.3TNF, IL2
13
Show member pathways
AhR pathway38
9.3IL2, TNF
149.3TNF, IL2
159.3IL2, TNF
169.0TNF, IL2RA, CD36
17
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
8.9IL2RA, IL2, TNF
18
Show member pathways
8.9IL2RA, IL2, TNF
19
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
8.9IL2RA, IL2, TNF
20
Show member pathways
8.9IL2RA, IL2, TNF
21
Show member pathways
8.9IL2RA, IL2, TNF
22
Show member pathways
8.9IL2RA, IL2, TNF
238.9IL2RA, IL2, TNF
24
Show member pathways
8.9IL2RA, IL2, TNF
25
Show member pathways
8.9TNF, IL2, IL2RA
26
Show member pathways
Ras signaling in the CD4+ TCR pathway38
8.9TNF, IL2, IL2RA
27
Show member pathways
8.9TNF, IL2, IL2RA

Compounds for genes affiliated with Farmer's Lung

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 3BitterDB, 29IUPHAR
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Compounds related to Farmer's Lung according to GeneCards/GeneDecks:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1mizoribine459.8IL2, IL2RA
2denileukin diftitox45 51 1111.6IL2RA, IL2
3pirfenidone45 6110.5IL2, CD36, IL2RA
4benzylpenicillin459.4IGHE, IL2
5mycophenolic acid45 51 1111.4IL2, IL2RA, IGHE
6gold sodium thiomalate459.3TNF, IL2, IL2RA
7piclamilast45 1110.3TNF, IL2
8okt3459.3TNF, IL2RA, IL2
92,5-oligoadenylate459.3IL2, TNF, IL2RA
10il 10459.3IL2RA, TNF, IL2
11budesonide45 51 1111.3IGHE, TNF, CD36
12infliximab45 51 1111.3TNF, IL2RA, IGHE
13ivig459.2TNF, IL2RA, IGHE
14pentoxifylline45 1110.2IL2, IL2RA, TNF
15interferon gamma459.2IL2, TNF
16glucosamine45 24 1111.2CD36, IL2, TNF
17neopterin459.2IL2, IL2RA, TNF
18rituximab45 51 1111.2IL2RA, IL2, TNF
19lamivudine45 51 1111.2SLPI, CD36, IL2RA
20chloroquine45 3 51 29 1113.2IL2, TNF, IL2RA
2125-hydroxyvitamin d459.2CD36, IL2RA, SLPI
22zoledronic acid459.1SLPI, IL2, CD36
23mifepristone45 29 61 1112.1PI3, IL2RA, SLPI
24mycophenolate mofetil45 51 1110.9IL2RA, IL2, TNF, CD36
25azathioprine45 3 51 1111.9IL2, IL2RA, SLPI
26thalidomide45 51 61 1111.9TNF, IL2, IL2RA, CD36
27etidronate458.9CD36, SLPI
28fluticasone propionate45 51 61 1111.9IGHE, SLPI, TNF
29herbimycin a45 619.9TNF, IL2RA, CD36, IL2
30tacrolimus45 51 1110.9TNF, IL2, IL2RA, CD36
31prednisolone45 29 1110.8IGHE, IL2RA, TNF, IL2
32indomethacin45 29 61 1111.8IGHE, IL2RA, IL2, TNF
33levamisole45 119.6SLPI, IL2RA, IL2, IGHE
34ascorbic acid45 249.6CD36, IL2RA, SLPI, IGHE
35vitamin d458.6SLPI, CD36, IL2RA, IGHE
36rantes458.5IL2, TNF, IL2RA, SLPI
37creatinine458.4IL2RA, IGHE, CD36, SLPI
38heparin45 29 24 1111.4CD36, IL2RA, IGHE, SLPI
39thymidine45 249.3SLPI, IL2RA, TNF, IL2
40actinomycin d458.3IGHE, TNF, IL2, SLPI
41calcitriol45 61 24 1111.1TNF, IL2, IL2RA, CD36, SLPI
42genistein45 29 61 3 24 1113.1IL2, SLPI, CD36, IL2RA, TNF
43pge2458.1IL2RA, SLPI, CD36, IL2, TNF
44retinoic acid45 249.0TNF, IGHE, CD36, SLPI, PI3
45hydrocortisone45 3 61 1111.0SLPI, IL2, IGHE, CD36, TNF
46cycloheximide457.9IGHE, SLPI, CD36, IL2, TNF
47histamine45 29 249.7PI3, SLPI, IL2RA, TNF, IGHE, IL2
48cyclosporin a45 29 619.6TNF, IL2, IL2RA, SLPI, IGHE, PI3
49vegf457.6IL2RA, CD36, IGHE, TNF, IL2, SLPI
50dexamethasone45 51 29 1110.2IL2, SLPI, IL2RA, IGHE, PI3, TNF

GO Terms for genes affiliated with Farmer's Lung

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Sources:
16Gene Ontology
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Cellular components related to Farmer's Lung according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0CD36, IL2RA, TNF

Biological processes related to Farmer's Lung according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell homeostatic proliferationGO:0460139.8IL2RA, IL2
2positive regulation of activated T cell proliferationGO:0421049.7IL2, IL2RA
3negative regulation of growth of symbiont in hostGO:0441309.6CD36, TNF
4defense response to Gram-positive bacteriumGO:0508309.5CD36, TNF
5positive regulation of interferon-gamma productionGO:0327299.4TNF, IL2
6positive regulation of interleukin-6 productionGO:0327559.3TNF, CD36
7negative regulation of endopeptidase activityGO:0109519.3SLPI, PI3
8negative regulation of inflammatory responseGO:0507289.2IL2RA, IL2
9negative regulation of viral genome replicationGO:0450719.2SLPI, TNF
10immune responseGO:0069559.0IL2RA, IL2, IGHE

Molecular functions related to Farmer's Lung according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.3SLPI, PI3

Products for genes affiliated with Farmer's Lung

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Farmer's Lung

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet