MCID: FRM003
MIFTS: 51

Farmer's Lung malady

Respiratory diseases, Immune diseases categories

Summaries for Farmer's Lung

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An extrinsic allergic alveolitis which is induced by the inhalation of spores (aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. it is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

MalaCards: Farmer's Lung, also known as farmers lung, is related to extrinsic allergic alveolitis and nephrotic syndrome. An important gene associated with Farmer's Lung is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Inflammatory Response Pathway and IL12 signaling mediated by STAT4. The compounds pirfenidone and pge2 have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and skin, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Farmer's Lung

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Immune diseases


Aliases & Descriptions:

farmer's lung 8 42 60
farmers lung 8 10 44
farmer's lung disease 48
farmers' lung 8


External Ids:

Disease Ontology8 DOID:14453
NCIt39 C34605
ICD9CM27 495.0
MeSH34 D005203
ICD10 via Orphanet26 J67.0
SNOMED-CT via Orphanet57 18690003
UMLS via Orphanet61 C0015634
MESH via Orphanet35 D005203
ICD1025 J67.0

Related Diseases for Farmer's Lung

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Farmer's Lung:



Diseases related to farmer's lung

Clinical Features for Farmer's Lung

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Drugs & Therapeutics for Farmer's Lung

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Farmer's Lung

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Genetic Tests for Farmer's Lung

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Anatomical Context for Farmer's Lung

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Sources:
32MalaCards
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MalaCards organs/tissues related to Farmer's Lung:

32
Lung, Testes, Skin, B cells

Animal Models for Farmer's Lung or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Farmer's Lung:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6IGHE, CD36, IL2RA, IL2, SLPI, TNF
2MP:00053977.3SLPI, IL2, IL2RA, CD36, IGHE, TNF

Publications for Farmer's Lung

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Sources:
50PubMed
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Articles related to Farmer's Lung:

(show top 50)    (show all 331)
idTitleAuthorsYear
1
Farmer's lung-induced hypersensitivity pneumonitis complicated by shock. (22005584)
2012
2
Farmer's lung disease and microbiological composition of hay: a case-control study. (16244894)
2005
3
Class-specific antibodies during follow up of patients with farmer's lung. (2340884)
1990
4
The distribution of pulmonary shadowing in farmer's lung. (3338238)
1988
5
Immunomodulating properties of lymphocytes activated by farmer's lung associated bacterium Thermoactinomyces vulgaris in vitro. (3264664)
1988
6
Lung-reactive antibodies in sera of patients with farmer's lung disease. (3296065)
1987
7
Immunoregulation in farmer's lung disease. Correlation between the surface phenotype and functional evaluations at pulmonary level. (3948574)
1986
8
Farmer's lung: know the symptoms before it's too late. (3851081)
1985
9
Familial aggregation of symptoms of farmer's lung. (6740278)
1984
10
Airborne molds and actinomycetes in the work environment of farmer's lung patients in Finland. (6382592)
1984
11
Incidence of farmer's lung leading to hospitalization and its relation to meteorological observations in Finland. (6613688)
1983
12
Red cell folate levels, food antibodies and reticulin antibodies in farmer's lung--is there an association with coeliac disease? (6639866)
1983
13
Leukocyte migration inhibition in farmer's lung. (7076981)
1982
14
Farmer's lung in an iron foundry. (7089528)
1982
15
Farmer's lung: industrial hazard for rural inhabitants. (7361144)
1980
16
Ultrastructural study of bronchopulmonary lavage liquid in farmer's lung disease. (6103201)
1980
17
Farmer's lung disease in Vermont. (375344)
1979
18
Experimental farmer's lung: immunological response in the rabbit to protein fractions of Micropolyspora faeni. (473844)
1979
19
Farmer's lung in a group of Scottish dairy farms. (911689)
1977
20
Farmer's lung: A neglected antigen. (73716)
1976
21
Proceedings: Farmer's lung and coeliac disease. (1278765)
1976
22
The quantitation of antibody in farmer's lung syndrome using a radioimmunoassay. Results of a clinical survey and comparison of three serological methods. (813924)
1975
23
Complement fixation test as an aid in the diagnosis of farmer's lung. (809482)
1975
24
Chest symptoms in farming communities with special reference to farmer's lung. (1156571)
1975
25
Farmer's lung. (4846024)
1974
26
Farmer's lung following inhalation of Aspergillus flavus growing in mouldy corn. (4207503)
1974
27
The diagnosis of farmer's lung. (4201951)
1973
28
Micropolyspora faeni and farmer's lung disease. (4632826)
1973
29
A bovine disease similar to farmer's lung: extrinsic allergic alveolitis. (4252199)
1971
30
The incidence of farmer's lung in Caithness. (4996723)
1971
31
Farmer's lung--an acute or chronic disease? (5273209)
1970
32
Farmer's lung, its geographic distribution. (5494072)
1970
33
Farmer's lung in a 10-year-old girl. (4980292)
1969
34
Precipitins with relevance to farmer's lung and aspergillosis in normal and other sera. (4983353)
1969
35
The long-term prognosis in farmer's lung. (5637938)
1968
36
Farmer's lung. (5637787)
1968
37
A comparison of the precipitin test in asymptomatic and symptomatic cases of farmer's lung. (4956123)
1966
38
Farmer's lung. (5946707)
1966
39
Farmer's lung: a review of current knowledge 1965. (5934504)
1966
40
Farmer's lung as observed in chest survey clinics. (5215338)
1965
41
Farmer's lung scheduled as a prescribed occupational disease in Great Britain. (5831722)
1965
42
"FOG FEVER" AND FARMER'S LUNG. (14315237)
1965
43
FARMER'S LUNG. (14305363)
1965
44
FARMER'S LUNG AND SILO-FILLER'S DISEASE. (14148161)
1964
45
ISOLATION OF THE CAUSATIVE AGENT OF FARMER'S LUNG. (14215933)
1964
46
Pulmonary infiltration with eosinophilia. Report of two cases of farmer's lung. (13718470)
1961
47
A syndrome resembling farmer's lung in workers inhaling spores of Aspergillus and Penicillia moulds. (13715832)
1960
48
Farmer's lung; an acute granulomatous interstitial pneumonitis occurring in agricultural workers. (13549229)
1958
49
Farmer's lung; a form of bronchopulmonary moniliasis. (13154160)
1954
50
A case of farmer's lung. (14913703)
1952

Genetic Variations for Farmer's Lung

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Expression for genes affiliated with Farmer's Lung

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Farmer's Lung

Search GEO for disease gene expression data for Farmer's Lung.

Pathways for genes affiliated with Farmer's Lung

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Farmer's Lung

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Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB, 24HMDB
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Compounds related to Farmer's Lung according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1pirfenidone44 5911.5CD36
2pge24410.5IL2
3mizoribine4410.1IL2, IL2RA
4denileukin diftitox44 49 1112.0IL2RA, IL2
5interferon gamma449.9TNF, IL2
6pentostatin44 59 28 1112.9IL2, IL2RA
7benzylpenicillin449.8IGHE, IL2
8c-d4t449.8IL2RA, IL2
9piclamilast44 1110.8IL2, TNF
10mycophenolate mofetil44 49 1111.7IL2, IL2RA, CD36
11gold sodium thiomalate449.7IL2, IL2RA, TNF
12okt3449.7IL2, IL2RA, TNF
132,5-oligoadenylate449.7TNF, IL2RA, IL2
14il 10449.7IL2, IL2RA, TNF
15mycophenolic acid44 49 1111.6IL2, IL2RA, IGHE
16neopterin449.6TNF, IL2RA, IL2
17lenalidomide44 1110.6IL2, TNF
18rituximab44 49 1111.6IL2, IL2RA, TNF
19hydrocortisone44 2 59 1112.6SLPI, IGHE
20chloroquine44 2 49 28 1113.6IL2, IL2RA, TNF
21infliximab44 49 1111.5TNF, IGHE, IL2RA
22ivig449.5IL2RA, IGHE, TNF
23budesonide44 49 1111.5CD36, IGHE, TNF
24etidronate449.5SLPI, CD36
25lamivudine44 1110.4SLPI, IL2RA, CD36
26thalidomide44 49 59 1112.4TNF, CD36, IL2RA, IL2
2725-hydroxyvitamin d449.3CD36, IL2RA, SLPI
28herbimycin a44 5910.3TNF, CD36, IL2RA, IL2
29tacrolimus44 49 1111.3TNF, CD36, IL2RA, IL2
30taurine chloramine449.3IL2, TNF
31alizarin449.3CD36, SLPI
32zoledronic acid449.3CD36, IL2, SLPI
33mifepristone44 59 28 1112.2SLPI, IL2RA, PI3
34prednisolone44 28 1111.2TNF, IGHE, IL2RA, IL2
35azathioprine44 49 2 1112.1IL2RA, IL2, SLPI
36fluticasone propionate44 49 59 1112.1TNF, IGHE, SLPI
37levamisole44 119.9SLPI, IL2, IL2RA, IGHE
38rantes448.8TNF, IL2RA, IL2, SLPI
39ascorbic acid44 249.8IGHE, CD36, IL2RA, SLPI
40vitamin d448.8IGHE, CD36, IL2RA, SLPI
41actinomycin d448.5TNF, IGHE, IL2, SLPI
42calcitriol44 59 11 2411.5TNF, CD36, IL2RA, IL2, SLPI
43genistein44 28 59 2 11 2413.5TNF, CD36, IL2RA, IL2, SLPI
44thymidine44 249.4TNF, IL2RA, IL2, SLPI
45cycloheximide448.3TNF, IGHE, CD36, IL2, SLPI
46retinoic acid44 249.1TNF, PI3, IGHE, CD36, SLPI
47histamine44 28 2410.0TNF, PI3, IGHE, IL2RA, IL2, SLPI
48cyclosporin a44 28 5910.0TNF, PI3, IGHE, IL2RA, IL2, SLPI
49vegf448.0TNF, IGHE, CD36, IL2RA, IL2, SLPI
50dexamethasone44 49 28 1110.7TNF, PI3, IGHE, CD36, IL2RA, IL2

GO Terms for genes affiliated with Farmer's Lung

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Sources:
16Gene Ontology
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Cellular components related to Farmer's Lung according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL2RA, CD36, TNF

Biological processes related to Farmer's Lung according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell homeostatic proliferationGO:0460139.9IL2, IL2RA
2positive regulation of activated T cell proliferationGO:0421049.8IL2, IL2RA
3negative regulation of growth of symbiont in hostGO:0441309.8CD36, TNF
4positive regulation of interleukin-6 productionGO:0327559.6CD36, TNF
5positive regulation of interferon-gamma productionGO:0327299.5IL2, TNF
6defense response to Gram-positive bacteriumGO:0508309.3CD36, TNF
7negative regulation of viral genome replicationGO:0450719.2TNF, SLPI

Molecular functions related to Farmer's Lung according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.3SLPI, PI3

Products for genes affiliated with Farmer's Lung

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Farmer's Lung

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet