MCID: FRM003
MIFTS: 38

Farmer's Lung malady

Respiratory, Immune categories

Summaries for Farmer's Lung

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 An extrinsic allergic alveolitis which is induced by the inhalation of spores (aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. it is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

MalaCards: Farmer's Lung, also known as farmers lung, is related to nephrotic syndrome and graves' disease. An important gene associated with Farmer's Lung is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Inflammatory Response Pathway and IL12 signaling mediated by STAT4. The compounds pirfenidone and pge2 have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and b cells, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Farmer's Lung

Sources:
8Disease Ontology, 43NIH Rare Diseases, 61UMLS, 10DISEASES, 45Novoseek, 49Orphanet, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory, Immune


Aliases & Descriptions:

farmer's lung 8 43 61
farmers lung 8 10 45
farmer's lung disease 49
farmers' lung 8


External Ids:

Disease Ontology8 DOID:14453
NCIt40 C34605
ICD9CM27 495.0
MeSH35 D005203
ICD10 via Orphanet26 J67.0
SNOMED-CT via Orphanet58 18690003
UMLS via Orphanet62 C0015634
MESH via Orphanet36 D005203
ICD1025 J67.0

Related Diseases for Farmer's Lung

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Farmer's Lung:



Diseases related to farmer's lung

Clinical Features for Farmer's Lung

Drugs & Therapeutics for Farmer's Lung

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Farmer's Lung

Drug clinical trials:

Search ClinicalTrials for Farmer's Lung

Search NIH Clinical Center for Farmer's Lung

Search CenterWatch for Farmer's Lung

Genetic Tests for Farmer's Lung

Anatomical Context for Farmer's Lung

Sources:
33MalaCards
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MalaCards organs/tissues related to Farmer's Lung:

33
Lung, Skin, B cells

Animal Models for Farmer's Lung or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Farmer's Lung:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6IGHE, CD36, IL2RA, IL2, SLPI, TNF
2MP:00053977.3SLPI, IL2, IL2RA, CD36, IGHE, TNF

Publications for Farmer's Lung

Sources:
51PubMed
See all sources

Articles related to Farmer's Lung:

(show top 50)    (show all 124)
idTitleAuthorsYear
1
Pesticides and other agricultural factors associated with self-reported farmer's lung among farm residents in the Agricultural Health Study. (17182642)
2007
2
Farmer's lung disease and microbiological composition of hay: a case-control study. (16244894)
2005
3
Tumor necrosis factor-alpha -308 promoter gene polymorphism and increased tumor necrosis factor serum bioactivity in farmer's lung patients. (11179110)
2001
4
Respiratory symptoms of obstructive lung disease in European crop farmers. (11029325)
2000
5
Farmer's lung: patients' IgG2 antibodies specifically recognize Saccharopolyspora rectivirgula proteins and carbohydrate structures. (8757222)
1996
6
Identification of the reactive subunits of Aspergillus umbrosus involved in the antigenic response in farmer's lung. (8809426)
1996
7
Relationship between severity of farmer's lung and the level of soluble interleukin 2 receptors in serum]. (8937141)
1996
8
Detection of specific antibodies in immune complexes of farmer's lung patients. (8705008)
1995
9
Monoclonal antibodies against farmer's lung antigens having specific binding to IgG antibodies. (8400887)
1993
10
A study of monokine release and natural killer activity in the bronchoalveolar lavage of subjects with farmer's lung. (8466130)
1993
11
Recovery of pulmonary function in farmer's lung. A five-year follow-up study. (8466111)
1993
12
Class specific antibodies in serodiagnosis of farmer's lung. (1599871)
1992
13
Two common fungi associated with farmer's lung: fine structure of Aspergillus fumigatus and Aspergillus umbrosus. (2067561)
1991
14
Etiological investigation of farmer's lung disease: a serological study. (1823809)
1991
15
Changes in the titers of IgG antibodies against farmer's lung antigens in the sera of healthy dairy farmers. (2337263)
1990
16
Farmer's lung in infants and small children. (2719181)
1989
17
Improved medium for recovery and enumeration of the farmer's lung organism, Saccharomonospora viridis. (2604405)
1989
18
Prevalence of serum precipitins against microbes in mouldy hay, and of chronic bronchitis and farmer's lung with respect to farmers' occupational health hazards. (3478212)
1987
19
IgG subclasses in farmer's lung. (3480825)
1987
20
Severe hypoxemia in farmer's lung with normal chest roentgenograms. (3665623)
1987
21
Precipitins against microbes in mouldy hay in the sera of farmers with farmer's lung or chronic bronchitis and of healthy farmers. (3478211)
1987
22
Lung-reactive antibodies in sera of patients with farmer's lung disease. (3296065)
1987
23
Immunological aspects of farmer's lung. A family study. (3626964)
1987
24
Circulating IgG antibodies against fungal and actinomycete antigens in the sera of farmer's lung patients from different countries. (3299100)
1987
25
Prevalence and incidence of chronic bronchitis and farmer's lung with respect to socioeconomic factors. (3499344)
1987
26
IgG subclasses in respiratory disorders: bronchopulmonary aspergillosis and farmer's lung. (3762548)
1986
27
Relationship among antigen contact, alveolitis, and clinical status in farmer's lung disease. (3942447)
1986
28
Determination by enzyme-linked immunosorbent assay (ELISA) of specific IgG antibody activities for diagnosis of farmer's lung disease. (4082173)
1985
29
Familial aggregation of symptoms of farmer's lung. (6740278)
1984
30
Antibodies of farmer's lung disease in patients of chronic non specific bronchitis. (7141480)
1982
31
A study of immunoglobulin G subclasses in patients with farmer's lung. (7249336)
1981
32
Serologically detectable HLA-A, B, and C loci antigens in farmer's lung disease. (7416619)
1980
33
Total selective deficiency of serum and secretory IgA associated with farmer's lung. (7326596)
1980
34
Seasonal variation in the incidence of farmer's lung. (7440044)
1980
35
Farmer's lung disease and coeliac disease: a prospective study. (591277)
1977
36
Use of a serologically distinct strain of Thermoactinomyces vulgaris in the diagnosis of farmer's lung disease. (1206112)
1975
37
Quantitation of antibody to particulate antigens using a radiolabelled anti-immunoglobulin reagent: application to estimation of antibody in farmer's lung syndrome. (4797446)
1973
38
Chest symptoms and farmer's lung: a community survey. (4723788)
1973
39
Serological investigations of a bovine respiratory disease ("urner pneumonie") resembling farmer's lung. (4628862)
1972
40
A study of farmer's lung. (5135392)
1971
41
Immunofluorescent studies in patients with farmer's lung. (4937457)
1971
42
Precipitins with relevance to farmer's lung and aspergillosis in normal and other sera. (4983353)
1969
43
The pathology of the acute and chronic stages of farmer's lung. (5680234)
1968
44
Simplified serologic test for farmer's lung. (4966435)
1968
45
Farmer's lung. Introduction. Identification study. (4954565)
1965
46
Inhalation and skin tests with extracts of hay and fungi in patients with farmer's lung. (14000894)
1963
47
FARMER'S LUNG: STUDIES OF PULMONARY FUNCTION AND AETIOLOGY. (14045128)
1963
48
FARMER'S LUNG. THERMOPHILIC ACTINOMYCETES AS A SOURCE OF "FARMER'S LUNG HAY" ANTIGEN. (14054440)
1963
49
Farmer's lung. I. An immunological study of some antigenic components of mouldy foodstuffs. (13941446)
1963
50
A Survey of " Farmer's Lung ". (19790385)
1961

Genetic Variations for Farmer's Lung

Expression for genes affiliated with Farmer's Lung

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Farmer's Lung

Search GEO for disease gene expression data for Farmer's Lung.

Pathways for genes affiliated with Farmer's Lung

Sources:
38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 30KEGG, 53R&D Systems
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Compounds for genes affiliated with Farmer's Lung

Sources:
45Novoseek, 60Tocris Bioscience, 50PharmGKB, 11DrugBank, 29IUPHAR, 2BitterDB, 24HMDB
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Compounds related to Farmer's Lung according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1pirfenidone45 6011.5CD36
2pge24510.5IL2
3mizoribine4510.1IL2RA, IL2
4denileukin diftitox45 50 1112.0IL2, IL2RA
5interferon gamma459.9TNF, IL2
6pentostatin45 60 29 1112.9IL2, IL2RA
7benzylpenicillin459.8IL2, IGHE
8piclamilast45 1110.8IL2, TNF
9c-d4t459.7IL2, IL2RA
10mycophenolate mofetil45 50 1111.7IL2, IL2RA, CD36
11gold sodium thiomalate459.7IL2RA, IL2, TNF
12okt3459.7IL2RA, IL2, TNF
132,5-oligoadenylate459.7IL2RA, IL2, TNF
14il 10459.7IL2RA, IL2, TNF
15mycophenolic acid45 50 1111.6IL2, IL2RA, IGHE
16neopterin459.6IL2, IL2RA, TNF
17taurine chloramine459.6TNF, IL2
18rituximab45 50 1111.6IL2, TNF, IL2RA
19hydrocortisone45 2 60 1112.6IGHE, SLPI
20chloroquine45 2 50 29 1113.6TNF, IL2RA, IL2
21infliximab45 50 1111.5TNF, IGHE, IL2RA
22ivig459.5TNF, IL2RA, IGHE
23budesonide45 50 1111.5TNF, CD36, IGHE
24etidronate459.5CD36, SLPI
25lamivudine45 1110.4IL2RA, SLPI, CD36
26thalidomide45 50 60 1112.4IL2, TNF, CD36, IL2RA
27alizarin459.3SLPI, CD36
2825-hydroxyvitamin d459.3SLPI, IL2RA, CD36
29herbimycin a45 6010.3IL2, CD36, TNF, IL2RA
30tacrolimus45 50 1111.3CD36, TNF, IL2, IL2RA
31lenalidomide45 1110.3IL2, TNF
32zoledronic acid459.3IL2, SLPI, CD36
33mifepristone45 60 29 1112.2PI3, IL2RA, SLPI
34prednisolone45 29 1111.2IL2RA, IGHE, IL2, TNF
35azathioprine45 50 2 1112.1IL2, IL2RA, SLPI
36fluticasone propionate45 50 60 1112.1IGHE, SLPI, TNF
37levamisole45 119.9SLPI, IL2, IL2RA, IGHE
38rantes458.8SLPI, IL2, IL2RA, TNF
39ascorbic acid45 249.8SLPI, CD36, IGHE, IL2RA
40vitamin d458.8IL2RA, SLPI, IGHE, CD36
41actinomycin d458.5TNF, IGHE, IL2, SLPI
42calcitriol45 60 11 2411.5SLPI, IL2RA, TNF, IL2, CD36
43genistein45 29 60 2 11 2413.5SLPI, TNF, IL2, IL2RA, CD36
44thymidine45 249.4IL2, SLPI, TNF, IL2RA
45cycloheximide458.3IGHE, CD36, SLPI, IL2, TNF
46retinoic acid45 249.1CD36, IGHE, PI3, TNF, SLPI
47histamine45 29 2410.0SLPI, IL2, IL2RA, IGHE, PI3, TNF
48cyclosporin a45 29 6010.0IGHE, IL2RA, PI3, TNF, SLPI, IL2
49vegf458.0IL2, SLPI, CD36, IGHE, TNF, IL2RA
50dexamethasone45 50 29 1110.7CD36, IGHE, PI3, TNF, IL2, IL2RA

GO Terms for genes affiliated with Farmer's Lung

Sources:
16Gene Ontology
See all sources

Cellular components related to Farmer's Lung according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL2RA, CD36, TNF

Biological processes related to Farmer's Lung according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell homeostatic proliferationGO:0460139.9IL2, IL2RA
2positive regulation of activated T cell proliferationGO:0421049.8IL2, IL2RA
3negative regulation of growth of symbiont in hostGO:0441309.8CD36, TNF
4positive regulation of interleukin-6 productionGO:0327559.6CD36, TNF
5positive regulation of interferon-gamma productionGO:0327299.5IL2, TNF
6defense response to Gram-positive bacteriumGO:0508309.3CD36, TNF
7negative regulation of viral genome replicationGO:0450719.2TNF, SLPI

Molecular functions related to Farmer's Lung according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.3SLPI, PI3

Products for genes affiliated with Farmer's Lung

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Farmer's Lung

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet