Fasciitis malady

Wikipedia: In medicine, fasciitis (pron.: /ˌfæʃiˈaɪtɪs/) refers to an inflammation of the fascia. In...⁴⁴ more...

MalaCards: Fasciitis is related to eosinophilic fasciitis and pseudosarcomatous fibromatosis. An important gene associated with Fasciitis is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are OX40 Pathway and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds ivig and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, monocytes and t cells, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Aliases & Descriptions:

fasciitis 6 8 32 43

Diseases related to fasciitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 771)

id	Related Disease	Score	Top Affiliating Genes
1	eosinophilic fasciitis	33.4	IL10, IL5, IFNG, TRB@, AHR
2	pseudosarcomatous fibromatosis	32.8	VIM, MYOG, CTNNB1, ACTC1, DES
3	necrotizing fasciitis	32.0	PIK3C2A, CD46, INS, CCNF, GPT, IGHE
4	plantar fasciitis	30.2	MED12, FABP6, CARD9, HLA-B, TRPC4AP, SHANK2
5	eosinophilia	26.9	PIK3C2A, INS, IL10, IL5, IGHE, IFNG
6	purpura	23.4	BMP6, CD46, IL10, IL5, IGHE, IFNA1
7	psoriasis	22.3	VIM, S100B, MMP1, INS, FGF7, IL10
8	leukemia	17.6	PIK3C2A, VIM, BMP6, CD34, CD46, MMP1
9	carcinoma	17.2	PIK3C2A, VIM, MYOG, BMP6, S100B, CD34
10	botryoid rhabdomyosarcoma	13.8	MYOG, ACTC1, DES
11	glomangiomyoma	13.8	VIM, ACTC1, DES
12	infantile myofibromatosis	13.8	VIM, ACTC1, DES
13	myofibroma	13.7	VIM, ACTC1, DES
14	cough variant asthma	13.7	IL10, IL5, IGHE
15	epithelioid leiomyosarcoma	13.7	VIM, ACTC1, DES
16	rectum sarcomatoid carcinoma	13.7	VIM, ACTC1, DES
17	myoma	13.7	CTNNB1, ACTC1, DES
18	lymph node palisaded myofibroblastoma	13.7	VIM, DES
19	myxosarcoma	13.7	VIM, DES
20	infantile digital fibromatosis	13.7	VIM, DES
21	prostate leiomyoma	13.7	VIM, DES
22	alveolar soft part sarcoma	13.7	VIM, MYOG, DES
23	silent myocardial infarction	13.7	PIK3C2A, INS
24	cystic nephroma	13.7	VIM, ACTC1, DES
25	endometrial stromal tumor	13.7	VIM, CTNNB1, DES
26	cutaneous leishmaniasis	13.7	IL10, IFNG
27	rhabdoid tumors	13.7	VIM, ACTC1, DES
28	orbit embryonal rhabdomyosarcoma	13.7	MYOG, ACTC1, DES
29	african tick-bite fever	13.6	IL10, GPT, IFNG
30	miliary tuberculosis	13.6	IL10, IGHE, IFNG
31	malignant mesenchymoma	13.6	MYOG, DES
32	malignant giant cell tumor of soft parts	13.6	S100B, ACTC1, DES
33	hypergammaglobulinemia	13.6	IL10, IL5, IGHE, TRB@
34	dysphagia	13.6	PIK3C2A, IL5, DES
35	postphlebitic syndrome	13.6	F5, DES
36	urinary schistosomiasis	13.6	IL10, IL5, IGHE, IFNG
37	allergic bronchopulmonary aspergillosis	13.6	IL10, IL5, IGHE, IFNG
38	inflammatory myofibroblastic tumor	13.6	VIM, ACTC1, DES
39	sarcomatoid mesothelioma	13.6	VIM, ACTC1, DES, NKX2-1
40	mucinous cystadenocarcinoma	13.6	VIM, ACTC1, NKX2-1
41	egg allergy	13.6	IL5, IGHE
42	meninges sarcoma	13.6	VIM, DES
43	allergic conjunctivitis	13.6	IL5, IGHE, IFNG
44	cutaneous fibrous histiocytoma	13.6	VIM, CD34, DES
45	eosinophilic esophagitis	13.6	IL10, IL5, IGHE, IFNG
46	pulmonary eosinophilia	13.6	IL5, IGHE, IFNG
47	pulmonary sclerosing hemangioma	13.6	CTNNB1, ACTC1, NKX2-1
48	neurilemmoma	13.6	VIM, CD34, DES
49	spindle cell lipoma	13.6	VIM, CD34, ACTC1, DES
50	ovarian sex cord tumors	13.5	VIM, ACTC1, DES

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to fasciitis:

²²

MGI Mouse Phenotypes related to fasciitis:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.7	NKX2-1, PITX2, IFNG, MITF
2	hematopoietic system phenotype	MP:0005397	9.5	MYH9, AHR, PITX2, TRB@, IGHE, IL5
3	liver/biliary system phenotype	MP:0005370	9.4	AHR, PITX2, TP53, TRB@, IFNG, INS
4	reproductive system phenotype	MP:0005389	9.2	NKX2-1, PITX2, TNFRSF1A, TNF, IFNG, IL10
5	renal/urinary system phenotype	MP:0005367	8.8	MYH9, NPHS1, AHR, CTNNB1, ESR1, INS
6	nervous system phenotype	MP:0003631	8.5	NKX2-1, NPHS1, PITX2, PLAU, TNFRSF1A, TRB@
7	limbs/digits/tail phenotype	MP:0005371	8.4	PITX2, CTNNB1, TNFRSF1A, ESR1, CCNF, IL10
8	digestive/alimentary phenotype	MP:0005381	8.4	PLAU, PITX2, AHR, NKX2-1, CTNNB1, TRB@
9	no phenotypic analysis	MP:0003012	7.9	MYH9, NKX2-1, AHR, PITX2, CTNNB1, TP53
10	immune system phenotype	MP:0005387	7.7	TNF, TNFRSF1A, PITX2, AHR, MYH9, TP53
11	vision/eye phenotype	MP:0005391	7.4	TNFRSF1A, CTNNB1, PLAU, PITX2, AHR, TNF
12	tumorigenesis	MP:0002006	6.9	NKX2-1, AHR, PLAU, CTNNB1, TNFRSF1A, TNF
13	cardiovascular system phenotype	MP:0005385	5.8	SPEG, CTNNB1, PLAU, PITX2, ACTC1, AHR
14	cellular phenotype	MP:0005384	5.6	TNF, TNFRSF1A, CTNNB1, PLAU, PITX2, ACTC1
15	embryogenesis phenotype	MP:0005380	INF	PES1, PITX2, CTNNB1, TNFRSF1A, CCNF, IL5
16	mortality/aging	MP:0010768	INF	PLAU, PITX2, AHR, DES, NPHS1, NKX2-1
17	integument phenotype	MP:0010771	INF	AHR, CTNNB1, TNFRSF1A, TP53, TRB@, F5
18	skeleton phenotype	MP:0005390	INF	PITX2, PLAU, CTNNB1, TNFRSF1A, TP53, ESR1
19	growth/size phenotype	MP:0005378	INF	CTNNB1, PLAU, PITX2, ACTC1, AHR, NKX2-1
20	respiratory system phenotype	MP:0005388	INF	PITX2, SPEG,
21	behavior/neurological phenotype	MP:0005386	INF	F5, TNFRSF1A, CTNNB1, DES, NKX2-1, IFNG
22	normal phenotype	MP:0002873	INF	MYH9, PITX2, TRB@, IFNG, IL10, MED12
23	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, TNFRSF1A, CTNNB1, PLAU, PITX2, ACTC1
24	muscle phenotype	MP:0005369	INF	CTNNB1, PLAU, PITX2, ACTC1, AHR, DES
25	adipose tissue phenotype	MP:0005375	INF	TNFRSF1A, TNF, TP53, ESR1, INS,

Articles related to fasciitis:

(show all 26)

id	Title	Authors	Year	Affiliating Genes
1	Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. (21826056)	Erickson-Johnson M.R.... Oliveira A.M.	2011	MYH9
2	AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-synd rome and toxic oil syndrome? (19941898)	Rieber N.... Belohradsky B.H.	2010	AHR
3	CD46 transgenic mouse model of necrotizing fasciitis caused by Streptococcus pyogenes infection. (19737905)	Matsui H.... Ubukata K.	2009	CD46
4	Necrotizing fasciitis. Case report. (19093634)	Costanzo M.... Cannizzaro M.A.	2008	INS
5	A subset of cranial fasciitis is associated with dysregulation of the Wnt/beta-catenin pathway. (18587328)	Rakheja D.... Weinberg A.G.	2008	CTNNB1
6	Papillary carcinoma with nodular fasciitis-like stroma--a case report in pregnancy. (18232002)	Leal I.I.... de Castro Montenegro F.S.	2008	NKX2-1
7	Cranial fasciitis of childhood: a case report and rev iew of literature. (18190448)	Hussein M.R.	2008	ACTC1
8	Occurrence of psoriasis in a patient presenting Shulman fasciitis treated with infliximab (17483757)	Cavailhes A.... Sigal-Grinberg M.	2007	TNF
9	Successful treatment using tacrolimus (FK506) in a patient with TNF receptor-associated periodic syndrome (TRAPS) complicated by monocytic fasciitis. (16801330)	Ida H.... Eguchi K.	2006	TNF
10	Is the L-tryptophan metabolite quinolinic acid respon sible for eosinophilic fasciitis? (16820992)	Noakes R.... Williamson R.	2006	IFNG
11	Intramuscular nodular fasciitis--a clinicopathologic al study with emphasis on myogenic giant cells (16341518)	Hansen T.... Katenkamp D.	2006	ACTC1
12	A gene expression signature that distinguishes desmoid tumours from nodular fasciitis. (16440290)	Bacac M.... Stamenkovic I.	2006	PLAU, MMP1, PITX2
13	Massive soft tissue infections: necrotizing fasciitis and purpura fulminans. (15715517)	Edlich R.F.... Long W.B.	2005	F5
14	Nodular fasciitis: diagnosis by fine needle aspiratio n biopsy. (15296335)	Kong C.S.... Cha I.	2004	ACTC1
15	The importance of serum creatine phosphokinase level in the early diagnosis and microbiological evaluation of necrotizing fasciitis. (15482296)	Simonart T.... Narisawa Y.	2004	PIK3C2A
16	Eosinophilic fasciitis and eosinophilic cellulitis in a patient with abnormal circulating clonal T cells: increased production of interleukin 5 and inhibition by interferon alfa. (14639411)	French L.E.... Rook A.H.	2003	IL5
17	Cytogenetic findings in a case of nodular fasciitis of subclavicular region. (12606136)	Velagaleti G.V.... Gatalica Z.	2003	FGF7
18	Vimentin, smooth muscle actin, desmin, S-100 protein, p53, and estrogen receptor expression in elastofibroma and nodular fasciitis. (12004356)	Kayaselcuk F.... Tuncer I.	2002	TP53, ESR1, S100B
19	Monocytic fasciitis: a newly recognized clinical feature of tumor necrosis factor receptor dysfunction. (12209524)	Hull K.M.... Kastner D.L.	2002	TNF, TNFRSF1A
20	Analysis of leukemia inhibitory factor, type 1 and type 2 cytokine production in patients with eosinophilic fasciitis. (11196547)	Viallard J.F.... Moreau J.F.	2001	IL10
21	Nodular fasciitis and solitary fibrous tumor of the oral region: tumors of fibroblast heterogeneity. (10225630)	Eversole L.R.... Sapp J.P.	1999	CD34, ACTC1
22	Cranial and extracranial fasciitis of childhood: a clinicopathologic and immunohistochemical study. (9923933)	Sarangarajan R.... Dehner L.P.	1999	ACTC1
23	Serum and synovial fluid levels of interleukin-5 in a patient with eosinophilic fasciitis. (9014593)	Nishiya K.... Tominaga A.	1996	IL5
24	Clinical manifestations, microbiology and prognosis of 42 patients with necrotizing fasciitis. (9000808)	Hung C.C.... Hsieh W.C.	1996	GPT
25	Necrotizing fasciitis in association with hyperimmunoglobulin E syndrome. (8537554)	Misago N.... Oka S.	1995	IGHE
26	Concurrent eosinophilic fasciitis and cutaneous T-cel l lymphoma. Eosinophilic fasciitis as a paraneoplastic syndrome of T-cell malig nant neoplasms? (2036034)	Chan L.S.... Cooper K.D.	1991	TRB@

Genes related to fasciitis according to GeneCards:

(show all 43)

id	Symbol	Description	Score	GeneCards Section Context
1	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
2	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
3	CCNF	cyclin F	11.0
4	SPEG	SPEG complex locus	11.0
5	PES1	pescadillo ribosomal biogenesis factor 1	11.0
6	FABP6	fatty acid binding protein 6, ileal	11.0
7	CD46	CD46 molecule, complement regulatory protein	11.0	Publications
8	NPHS1	nephrosis 1, congenital, Finnish type (nephrin)	11.0
9	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
10	DES	desmin	11.0	Publications
11	AHR	aryl hydrocarbon receptor	11.0	Publications
12	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
13	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
14	TRB@	T cell receptor beta locus	11.0	Publications
15	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications
16	SHANK2	SH3 and multiple ankyrin repeat domains 2	11.0
17	IL10	interleukin 10	11.0	Publications
18	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
19	VIM	vimentin	11.0	Publications
20	IFNG	interferon, gamma	11.0	Publications
21	INS	insulin	11.0	Publications
22	CARD9	caspase recruitment domain family, member 9	11.0
23	NKX2-1	NK2 homeobox 1	11.0	Publications
24	PITX2	paired-like homeodomain 2	11.0	Publications
25	FGF7	fibroblast growth factor 7	11.0	Publications
26	NLRP11	NLR family, pyrin domain containing 11	11.0
27	CD34	CD34 molecule	11.0	Publications
28	TRPC4AP	transient receptor potential cation channel, subfamily C, member 4 associated protein	11.0
29	AAK1	AP2 associated kinase 1	11.0
30	MED12	mediator complex subunit 12	11.0
31	MYH9	myosin, heavy chain 9, non-muscle	11.0	Publications
32	MITF	microphthalmia-associated transcription factor	11.0	Publications
33	EYA2	eyes absent homolog 2 (Drosophila)	11.0	Publications
34	S100B	S100 calcium binding protein B	11.0	Publications
35	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
36	BMP6	bone morphogenetic protein 6	11.0	Publications
37	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
38	PLAU	plasminogen activator, urokinase	11.0	Publications
39	HLA-B	major histocompatibility complex, class I, B	11.0
40	IFNA1	interferon, alpha 1	11.0	Publications
41	TP53	tumor protein p53	11.0	Publications
42	ESR1	estrogen receptor 1	11.0	Publications
43	TNF	tumor necrosis factor	11.0	Publications

Pathways related to fasciitis according to GeneDecks:

(show all 24)

id	Pathway	Score	Top Affiliating Genes
1	OX40 Pathway36	10.5	IL5
2	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.4	TNFRSF1A
3	PGC1Alpha Pathway36	10.0	TNFRSF1A, IL5, BMP6
4	SOCS Pathway36	9.8	IL5, IL10, FGF7, INS, BMP6
5	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.8	IL10, TNF, TNFRSF1A
6	THC Differentiation Pathway36	9.7	TNFRSF1A, TNF, IFNG, IL10
7	MIF Regulation of Innate Immune Cells36	9.7	TNF, IL5, IL10, BMP6
8	ILK Signaling36	9.6	MYH9, CTNNB1, TNFRSF1A, FGF7, VIM
9	Autoimmune thyroid disease20	9.6	IL10, IL5, IFNA1, HLA-B
10	Type I diabetes mellitus20	9.5	TNF, HLA-B, IFNG, INS
11	Allograft rejection20	9.5	TNF, HLA-B, IFNG, IL5, IL10
12	Immune response_MIF-mediated glucocorticoid regulation41	9.4	MMP1, IFNG, TNF
13	Cytokine Network36	9.4	IL10, IL5, IFNA1, IFNG, TNF
14	TGF-beta signaling pathway20	9.3	PITX2, TNF, IFNG, BMP6
15	Akt Signaling36	9.3	FGF7, IL10, TNF, TNFRSF1A
16	Immune response MIF-mediated glucocorticoid regulation10	9.1	MMP1, IFNG, TNF
17	JAK-STAT Pathway36	9.0	TNFRSF1A, IFNG, IFNA1, IL5, IL10, FGF7
18	Tuberculosis20	9.0	TNFRSF1A, TNF, CARD9, IFNG, IFNA1, IL10
19	Cytokine-cytokine receptor interaction20	8.9	TNFRSF1A, TNF, IFNG, IFNA1, IL5, IL10
20	PAK Pathway36	8.8	MYH9, TNF, IL5, IL10, FGF7, BMP6
21	Antioxidant Action of Vitamin-C36	8.8	MYH9, TNFRSF1A, TNF, IL5, IL10, FGF7
22	Apoptotic Pathways in Synovial Fibroblasts36	8.7	TNFRSF1A, TNF, TP53, FGF7, BMP6
23	Colorectal Cancer Metastasis36	8.7	CTNNB1, TNFRSF1A, TNF, TP53, IFNG, MMP1
24	p38 Signaling36	8.4	TNFRSF1A, TNF, TP53, IL5, IL10, FGF7

Compounds related to fasciitis according to GeneDecks:

(show top 50)    (show all 203)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.8	PIK3C2A
2	cyclophosphamide32 34 9 9	13.3	TRB@
3	progestin32	9.9	VIM, F5, PLAU, AHR, DES
4	pge232	9.7	PLAU, IL5, FGF7, MMP1
5	histamine32 18	10.3	IGHE, VIM, BMP6, FGF7, IL5, PLAU
6	hematoxylin32	9.2	NKX2-1, VIM, S100B, CD34, MMP1, ACTC1
7	reticulin32	9.2	S100B, BMP6, IFNA1, CD34, DES, ACTC1
8	aspartate32	9.1	F5, PLAU, PIK3C2A, VIM, BMP6, S100B
9	imiquimod32 42 9 9	12.0	IL5, IL10, BMP6, IFNG, IFNA1, TNF
10	simvastatin32 34 42 9 18 9	13.8	GPT, TNFRSF1A, IFNG, TNF, F5, PIK3C2A
11	imatinib32 34 9 9	11.8	IFNA1, IL5, FGF7, BMP6, S100B, CTNNB1
12	mycophenolate mofetil32 9 9	10.7	F5, IFNA1, GPT, IL10, MMP1, IFNG
13	sb 20358032 42	9.7	AHR, PLAU, CTNNB1, TNF, IFNG, BMP6
14	atorvastatin32 34 9 18 9	12.6	F5, MMP1, IL10, AHR, PLAU, GPT
15	progesterone32 42 9 18 9	12.5	NKX2-1, DES, ACTC1, PLAU, CTNNB1, ESR1
16	glutamate32	8.5	GPT, AHR, SHANK2, PLAU, TNFRSF1A, INS
17	prednisolone32 9 9	10.4	GPT, TNF, IFNG, IGHE, IFNA1, IL5
18	herbimycin a32 42	9.3	BMP6, MMP1, IL5, IFNG, TNF, TNFRSF1A
19	vitamin d32	8.3	IL10, VIM, IL5, CTNNB1, ESR1, AHR
20	glutamine32	8.2	S100B, BMP6, VIM, CTNNB1, FGF7, IL5
21	tgf beta132	8.2	PLAU, CTNNB1, TNFRSF1A, TNF, FGF7, MMP1
22	adriamycin32	8.2	DES, PLAU, CTNNB1, TNFRSF1A, TP53, IFNA1
23	arginine32	8.2	DES, PITX2, AHR, PLAU, HLA-B, IGHE
24	hydrocortisone32 9 9	10.1	PLAU, TNF, F5, IFNG, IGHE, IL5
25	indomethacin32 9 9	10.1	VIM, IL5, BMP6, NPHS1, PLAU, TNFRSF1A
26	tacrolimus32 34 9 9	10.9	IL10, MITF, IFNA1, BMP6, TNF, HLA-B
27	methotrexate32 34 42 9 9	11.7	GPT, TNF, IL5, IL10, MMP1, BMP6
28	rantes32	7.6	TNF, IFNA1, TNFRSF1A, IFNG, BMP6, IL5
29	lactate32	7.5	S100B, VIM, PLAU, TNF, PIK3C2A, HLA-B
30	alanine32	7.4	IFNA1, PLAU, AHR, TNFRSF1A, BMP6, CD46
31	tamoxifen32 34 9 9	10.2	ESR1, F5, IFNA1, FGF7, BMP6, VIM
32	retinoid32	7.1	CTNNB1, BMP6, VIM, AHR, PLAU, IFNG
33	thymidine32 18	8.1	PLAU, CTNNB1, TNF, IFNG, IFNA1, IL10
34	cyclosporin a32 42	7.8	HLA-B, IFNG, IFNA1, IGHE, GPT, IL5
35	doxorubicin32 34 9 9	9.8	IFNA1, ESR1, BMP6, TP53, VIM, MMP1
36	actinomycin d32	6.8	ESR1, VIM, TP53, TNFRSF1A, PLAU, AHR
37	dexamethasone32 42 34 9 9	10.3	IFNG, NPHS1, IFNA1, IGHE, IL5, IL10
38	cycloheximide32	5.7	VIM, AHR, PLAU, CTNNB1, BMP6, CD46
39	steroid32	INF	ACTC1, PLAU, CTNNB1, AHR, HLA-B, NKX2-1
40	12-o-tetradecanoylphorbol 13-acetate32	INF	PES1, FGF7, PLAU, , MITF, CD34
41	creatinine32	INF	IGHE, F5, HLA-B, TNFRSF1A, S100B, ACTC1
42	estrogen32	INF	ESR1, IGHE, FGF7, INS, ACTC1, CD34
43	rapamycin32 42	INF	IFNG, FGF7, INS, CD46, , VIM
44	ly29400232	INF	PIK3C2A, TNF, , IL10
45	testosterone32 9 18 9	INF	IL5, MMP1, IGHE, F5, ESR1, INS
46	vegf32	INF	DES, AHR, ACTC1, PLAU, CTNNB1, TNFRSF1A
47	retinoic acid32 42 18	INF	IL5, IGHE, IFNA1, IFNG, F5, ESR1
48	tyrosine32	INF	MITF, INS, FGF7, CD46, NKX2-1, S100B
49	serine32	INF	CD46, S100B, , VIM, BMP6, MMP1
50	paraffin32	INF	NKX2-1, DES, ACTC1, PLAU, VIM, CTNNB1

Cellular components related to fasciitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cell leading edge	GO:031252	9.5	MYH9, AAK1, VIM
2	extracellular space	GO:005615	7.9	BMP6, PLAU, TNFRSF1A, TNF, F5, IFNG
3	transcription factor complex	GO:005667	INF	, CTNNB1, PITX2, AHR, NKX2-1

Biological processes related to fasciitis according to GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	myoblast fusion	GO:007520	10.2	MYH9, NPHS1, PITX2
2	positive regulation of vitamin D biosynthetic process	GO:060557	10.0	IFNG, TNF
3	negative regulation of growth of symbiont in host	GO:044130	9.9	TNF, IFNG, IL10
4	positive regulation of podosome assembly	GO:071803	9.9	TNF, IL5
5	negative regulation of interleukin-6 production	GO:032715	9.7	TNFRSF1A, TNF, IL10
6	positive regulation of cytokine secretion	GO:050715	9.7	INS, IL10, TNF
7	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.7	TNF, IFNG
8	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.6	TP53, IL5, FGF7, INS
9	receptor biosynthetic process	GO:032800	9.5	TNF, IL10
10	response to drug	GO:042493	9.4	ACTC1, CTNNB1, TNF, CARD9, IFNG, IL10
11	protein import into nucleus, translocation	GO:000060	9.3	IFNG, TP53, TNF
12	positive regulation of nitric oxide biosynthetic process	GO:045429	9.1	TNF, ESR1, IFNG, INS
13	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.0	TNF, ESR1, IL5, IL10
14	negative regulation of gene expression	GO:010629	8.8	TNFRSF1A, TNF, ESR1, CD34
15	positive regulation of transcription, DNA-dependent	GO:045893	8.6	NKX2-1, CTNNB1, TNF, TP53, IL5, IL10
16	virus-host interaction	GO:019048	8.4	VIM, CD46, MMP1, HLA-B, TP53, TNFRSF1A
17	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	, NKX2-1, PITX2, CTNNB1, TNFRSF1A, TNF

Molecular functions related to fasciitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:005125	9.2	BMP6, IL10, IL5, IFNG, TNF
2	protease binding	GO:002020	8.7	TNFRSF1A, TNF, TP53, INS
3	transcription regulatory region DNA binding	GO:044212	8.6	NKX2-1, AHR, CTNNB1, TNF, TP53
4	protein binding	GO:005515	4.7	VIM, CTNNB1, PLAU, PITX2, SHANK2, AHR