MCID: FSC002
MIFTS: 39

Fascioliasis

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Fascioliasis

MalaCards integrated aliases for Fascioliasis:

Name: Fascioliasis 12 50 52 3 42 14 69
Fasciola Hepatica Infection 12 69
Sheep Liver Fluke Infection 12
Infection by Fasciola 12
Liver Flukes Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:885
ICD10 33 B66.3
ICD9CM 35 121.3
MeSH 42 D005211
SNOMED-CT 64 111922007 187125007
UMLS 69 C0015652

Summaries for Fascioliasis

CDC : 3 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as "the common liver fluke" or "the sheep liver fluke." A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all 5 continents, in over 50 countries, especially where sheep or cattle are reared. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The immature larval flukes migrate through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes, which produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards based summary : Fascioliasis, also known as fasciola hepatica infection, is related to cysticercosis and htra1-related autosomal dominant cerebral small vessel disease. An important gene associated with Fascioliasis is SLC17A5 (Solute Carrier Family 17 Member 5), and among its related pathways/superpathways are Allograft rejection and Toxoplasmosis. Affiliated tissues include liver, lung and testes.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Related Diseases for Fascioliasis

Diseases related to Fascioliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
id Related Disease Score Top Affiliating Genes
1 cysticercosis 30.3 MT-CO1 SELE
2 htra1-related autosomal dominant cerebral small vessel disease 10.8 GPT SLC17A5
3 quinquaud's decalvans folliculitis 10.8 GPT SLC17A5
4 neurogenic thoracic outlet syndrome 10.7 ALPP GPT
5 x-linked dominant intellectual disability-epilepsy syndrome 10.6 IL1B SLC17A5
6 chancroid 10.5 GPT IL1B
7 q fever 10.5 ALPP MT-CO1
8 addison's disease 10.5 ALPP MT-CO1
9 sex differentiation disease 10.5 ALB ALPP
10 congenital nonspherocytic hemolytic anemia 10.5 ALB IL1B
11 common cold 10.5 ALB SLC17A5
12 dermatomycosis 10.5 ALB SELE
13 ovarian surface papilloma 10.5 IL10 IL1B
14 female infertility of uterine origin 10.5 ALB GPT SLC17A5
15 eye accommodation disease 10.5 IFNG IL10
16 uterine corpus adenosarcoma 10.5 ALPP MT-CO1
17 microcephaly 8, primary, autosomal recessive 10.5 ALB GPT SLC17A5
18 acute lymphocytic leukemia 10.4 ALB GPT SLC17A5
19 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.4 IL1B SELE
20 pancreatic cystadenocarcinoma 10.4 ALB ALPP GPT
21 graft-versus-host disease, protection against 10.4 IFNG IL10
22 thelaziasis 10.4 IFNG IL10
23 dumping syndrome 10.4 IFNG IL10
24 congenital hypoplastic anemia 10.4 ALB GPT SLC17A5
25 moved to 244450 10.4 IL1B SELE
26 noninfectious dermatoses of eyelid 10.4 ALB GPT SLC17A5
27 acanthoma 10.4 IFNG SLC17A5
28 indian tick typhus 10.4 IFNG SELE
29 gerstmann syndrome 10.4 IFNG IL10
30 centronuclear myopathy 5 10.4 IFNG IL10
31 strawberry gallbladder 10.4 IFNG IL10
32 exudative vitreoretinopathy 2, x-linked 10.4 ALB MT-CO1
33 oropharyngeal cancer, childhood 10.4 IFNG IL10
34 polyarteritis nodosa 10.4 ALB IFNG
35 sternal cleft 10.4 IFNG IL1B
36 lymphedema 10.4 ALB GPT SLC17A5
37 hepatitis 10.4
38 herpangina 10.3 IFNG IL10
39 submucous uterine fibroid 10.3 ALB INS
40 ethmoid sinus cancer 10.3 IFNG IL1B
41 acute necrotizing encephalitis 10.3 ALB IFNG
42 papillary squamous carcinoma 10.3 IFNG IL10
43 spindle cell hemangioma 10.3 IFNG IL10
44 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.3 IFNG IL10
45 amyotrophic lateral sclerosis type 10 10.3 IFNG IL1B
46 cataract, autosomal dominant congenital 4 10.3 INS SELE
47 histoplasmosis retinitis 10.3 IL1B MT-CO1
48 reproductive system disease 10.3 IL10 MT-CO1
49 ampulla of vater neoplasm 10.3 IL1B SELE SLC17A5
50 schistosomiasis 10.2

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to Fascioliasis

Symptoms & Phenotypes for Fascioliasis

Drugs & Therapeutics for Fascioliasis

Search Clinical Trials , NIH Clinical Center for Fascioliasis

Cochrane evidence based reviews: fascioliasis

Genetic Tests for Fascioliasis

Anatomical Context for Fascioliasis

MalaCards organs/tissues related to Fascioliasis:

39
Liver, Lung, Testes, Brain, T Cells, Endothelial, Skin

Publications for Fascioliasis

Articles related to Fascioliasis:

(show top 50) (show all 555)
id Title Authors Year
1
Expression, purification and in vitro refolding of the recombinant truncated Saposin-like protein 2 antigen for development of diagnosis of human fascioliasis. ( 28300559 )
2017
2
DNA multigene characterization of Fasciola hepatica and Lymnaea neotropica and its fascioliasis transmission capacity in Uruguay, with historical correlation, human report review and infection risk analysis. ( 28158188 )
2017
3
Prevalence of fascioliasis (liver flukes) infection in cattle and buffaloes slaughtered at the municipal abattoir of El-Kharga, Egypt. ( 28919682 )
2017
4
A case of biliary fascioliasis mimicking a common bile duct tumor (with video). ( 28440243 )
2017
5
Human fascioliasis by Fasciola hepatica: the first case report in Nepal. ( 28870243 )
2017
6
Production of Monoclonal Antibody Against Excretory-Secretory Antigen of Fasciola hepatica and Evaluation of Its Efficacy in the Diagnosis of Fascioliasis. ( 28186433 )
2017
7
Immunodiagnosis of Human Fascioliasis: An Update of Concepts and Performances of the Serological Assays. ( 28764235 )
2017
8
Fascioliasis: A Rare Parasitic Infection-Mimicking Tumor in the Liver: Report of Two Cases. ( 28272650 )
2017
9
Fascioliasis-a rare cause of hepatic nodules. ( 28566417 )
2017
10
Seroprevalence and Risk Factors of Fascioliasis in Yaks, Bos grunniens, from Three Counties of Gansu Province, China. ( 28285513 )
2017
11
High prevalence of cattle fascioliasis in coastal areas of Thua Thien Hue province, Vietnam. ( 28458272 )
2017
12
Fascioliasis risk factors and space-time clusters in domestic ruminants in Bangladesh. ( 28482863 )
2017
13
Hepatic fascioliasis in Mashhad, Northeast Iran: first report. ( 28954086 )
2017
14
Human Cases of Fascioliasis in Fujian Province, China. ( 28285507 )
2017
15
A pediatric case of Fascioliasis with eosinophilic pneumonia. ( 27922247 )
2016
16
Epidemiological analysis of human fascioliasis in northeastern Punjab, Pakistan. ( 26763724 )
2016
17
Seroprevalence of Human Fascioliasis in Chaharmahal and Bakhtiyari Province, Southwestern Iran. ( 27648421 )
2016
18
Human fascioliasis endemic areas in Argentina: multigene characterisation of the lymnaeid vectors and climatic-environmental assessment of the transmission pattern. ( 27229862 )
2016
19
Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in blood samples diagnosed in Medic Medical Center Laboratory, Ho Chi Minh City, Vietnam in 2012. ( 27595647 )
2016
20
First Report of Human Fascioliasis in an Endemic Region of Bovine Fascioliasis in Caldas-Colombia. ( 27045315 )
2016
21
Evaluation of patients diagnosed with fascioliasis: A six-year experience at a university hospital in Turkey. ( 27131001 )
2016
22
Evaluation of modified Dennis parasitological technique for diagnosis of bovine fascioliasis. ( 27622626 )
2016
23
Treatment Failure after Multiple Courses of Triclabendazole among Patients with Fascioliasis in Cusco, Peru: A Case Series. ( 26808543 )
2016
24
Development of Two FhSAP2 Recombinant-Based Assays for Immunodiagnosis of Human Chronic Fascioliasis. ( 27549636 )
2016
25
Animal Fascioliasis: Perspectives from high altitudinal regions. ( 27890078 )
2016
26
Fascioliasis: An Ongoing Zoonotic Trematode Infection. ( 26417603 )
2015
27
Access to, and use of, water by populations living in a schistosomiasis and fascioliasis co-endemic area of northern CA'te d'Ivoire. ( 26004285 )
2015
28
Seroprevalence of human fascioliasis in Van province, Turkey. ( 26006203 )
2015
29
Screening for Zoonotic Fascioliasis in Slaughtered Large Ruminants in Abattoirs in Perak, Malaysia. ( 26868715 )
2015
30
Fascioliasis simulating an intrahepatic cholangiocarcinoma-Case report with imaging and pathology correlation. ( 25713810 )
2015
31
Biochemical assessment of oxidative status versus liver enzymes in patients with chronic fascioliasis. ( 26688624 )
2015
32
Biliary Fascioliasis Diagnosed on EUS. ( 26394385 )
2015
33
CLINICOPATHOLOGIC CORRELATES OF FASCIOLIASIS IN TWO EASTERN GREY KANGAROOS (MACROPUS GIGANTEUS). ( 26667560 )
2015
34
A Case of Fascioliasis Treated Successfully Without Sequelae in a Japanese Expatriate Living in Jakarta. ( 26309420 )
2015
35
Epidemiology of Human Fascioliasis and Intestinal Helminthes in Rural Areas of Boyer-Ahmad Township, Southwest Iran; A Population Based Study. ( 26744710 )
2015
36
Endoscopic Extraction of Biliary Fascioliasis Diagnosed Using Intraductal Ultrasonography in a Patient with Acute Cholangitis. ( 26668810 )
2015
37
The Endemicity of Human Fascioliasis in Guilan Province, Northern Iran: the Baseline for Implementation of Control Strategies. ( 26056669 )
2015
38
Education and imaging. Hepatology: Fascioliasis: a rare cause of hepatic pseudoaneurysmal rupture. ( 25536460 )
2015
39
Fascioliasis in Australian travellers to Bali. ( 26268290 )
2015
40
Developing a climate-based risk map of fascioliasis outbreaks in Iran. ( 25982974 )
2015
41
Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children. ( 26312936 )
2015
42
Human Fascioliasis: A Re-emerging Disease in Upper Egypt. ( 25870421 )
2015
43
Pathology in practice. Distomiasis (fascioliasis) in a New Mexico Dahl sheep. ( 26043127 )
2015
44
Performance of a 27 kDa Fasciola hepatica Antigen in the Diagnosis of Human Fascioliasis. ( 25949054 )
2015
45
Familial Trichostrongylus Infection Misdiagnosed as Acute Fascioliasis. ( 26402161 )
2015
46
The Status of Human and Animal Fascioliasis in Iran: A Narrative Review Article. ( 26622287 )
2015
47
Diagnosis of human fascioliasis in Arusha region, northern Tanzania by microscopy and clinical manifestations in patients. ( 26695775 )
2015
48
Finding of biliary fascioliasis by endoscopic ultrasonography in a patient with eosinophilic liver abscess. ( 25473389 )
2014
49
Distribution and abundance of schistosomiasis and fascioliasis host snails along the Mara River in Kenya and Tanzania. ( 25405008 )
2014
50
An incidental case of biliary fascioliasis mimicking cholangiocellular carcinoma. ( 25551848 )
2014

Variations for Fascioliasis

Expression for Fascioliasis

Search GEO for disease gene expression data for Fascioliasis.

Pathways for Fascioliasis

Pathways related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 22)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.46 CTSL IFNG IL10 IL1B INS
2
Show member pathways
12.05 IFNG IL10 IL1B
3 12.02 IFNG IL10 IL1B
4
Show member pathways
11.96 CTSL IFNG IL1B
5
Show member pathways
11.93 IFNG IL10 IL1B
6 11.86 ALB ALPP INS
7 11.73 IFNG IL1B INS
8
Show member pathways
11.72 IFNG IL10 IL1B
9 11.7 CTSL IFNG IL1B SELE
10 11.65 IFNG IL10 IL1B
11 11.61 CTSL IFNG IL1B
12 11.54 IFNG IL10 IL1B
13 11.49 IFNG IL10 IL1B
14
Show member pathways
11.38 IFNG IL1B SELE
15 11.28 IFNG INS SELE
16 11.11 IFNG IL1B
17 11 IFNG IL10
18 10.97 IFNG IL1B
19 10.95 IFNG IL10 IL1B SELE
20 10.81 IFNG IL10 IL1B
21 10.74 GPT INS
22 10.47 IFNG IL10 IL1B SELE

GO Terms for Fascioliasis

Cellular components related to Fascioliasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 ALB CTSL GPT IFNG IL10 IL1B

Biological processes related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.71 IL10 IL1B SELE
2 positive regulation of cytokine secretion GO:0050715 9.52 IL10 INS
3 positive regulation of mitotic nuclear division GO:0045840 9.51 IL1B INS
4 defense response to protozoan GO:0042832 9.49 IFNG IL10
5 negative regulation of lipid catabolic process GO:0050995 9.48 IL1B INS
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.46 IFNG IL1B
7 negative regulation of growth of symbiont in host GO:0044130 9.43 IFNG IL10
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.4 IL10 IL1B
9 positive regulation of chemokine biosynthetic process GO:0045080 9.37 IFNG IL1B
10 regulation of defense response to virus by host GO:0050691 9.32 IFNG IL1B
11 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.26 IFNG IL1B
12 positive regulation of MHC class II biosynthetic process GO:0045348 9.16 IFNG IL10
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.13 IFNG IL1B INS
14 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.62 IFNG IL1B

Sources for Fascioliasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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