MCID: FSC002
MIFTS: 38

Fascioliasis malady

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Fascioliasis

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Aliases & Descriptions for Fascioliasis:

Name: Fascioliasis 11 47 49 2 38 13 67
Fasciola Hepatica Infection 11 67
Sheep Liver Fluke Infection 11
 
Infection by Fasciola 11
Liver Flukes Nos 11

Classifications:



External Ids:

Disease Ontology11 DOID:885
ICD1029 B66.3
ICD9CM31 121.3
MeSH38 D005211

Summaries for Fascioliasis

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CDC:2 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as "the common liver fluke" or "the sheep liver fluke." A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all 5 continents, in over 50 countries, especially where sheep or cattle are reared. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The immature larval flukes migrate through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes, which produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards based summary: Fascioliasis, also known as fasciola hepatica infection, is related to oral erosive lichen and acute lymphocytic leukemia. An important gene associated with Fascioliasis is SLC17A5 (Solute Carrier Family 17 Member 5), and among its related pathways are IL-10 Pathway and Cytokines and Inflammatory Response. Affiliated tissues include liver, lung and testes, and related mouse phenotype liver/biliary system.

Disease Ontology:11 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Related Diseases for Fascioliasis

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Diseases related to Fascioliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1oral erosive lichen10.6GPT, SLC17A5
2acute lymphocytic leukemia10.5GPT, SLC17A5
3fraxf syndrome10.5ALPP, GPT
4pancreatic solid pseudopapillary carcinoma10.5ALB, SLC17A5
5postinflammatory pulmonary fibrosis10.5CP, GPT
6multiple system atrophy with orthostatic hypotension10.5ALB, CP
7fibrous histiocytoma10.4ALB, GPT
8hole retinal cyst10.4ALB, INS
9constrictive pericarditis10.4ALB, INS
10antidepressant type abuse10.4ALB, INS
11conjunctival vascular disease10.4ALB, INS
12hepatitis10.3
13agammaglobulinemia 610.3ALB, INS
14paranasal sinus cancer, adult10.3CP, INS
15mastocytosis cutaneous with short stature conductive hearing loss and microtia10.3GPT, IL10
16spastic monoplegia10.3ALB, IL10
17alveolar periostitis10.3ALB, GPT, SLC17A5
18hepatic coma10.3ALB, GPT, SLC17A5
19pancreatic vasoactive intestinal peptide producing tumor10.3ALB, INS
20duodenal disease10.3ALB, ALPP, GPT
21intraorbital meningioma10.3ALB, GPT
22smooth muscle tumor10.3ALB, IL10
2310.3ALB, IL10
24extrahepatic cholestasis10.3ALB, ALPP, GPT
25schistosomiasis10.2
26chromoblastomycosis10.2ALB, SELE
27acquired gastric outlet stenosis10.2CP, SELE
28nondystrophic myotonia10.2GPT, INS, SLC17A5
29silver-russell syndrome due to 7p11.2p13 microduplication10.2IL1B, SLC17A5
30extrapulmonary tuberculosis10.2CTSL, IL10
31urinary bladder posterior wall cancer10.2ALB, CP, GPT
32casr-related disorders10.2INS, SELE
33spinocerebellar ataxia 810.2ALB, CP, GPT
34midline interhemispheric variant of holoprosencephaly10.1IL1B, SLC17A5
35pontocerebellar hypoplasia10.1IL10, INS
36labyrinthine bilateral reactive loss10.1INS, SELE
37plantar wart10.1GPT, IL1B
38alopecia10.1ALB, IL10
39calcifying epithelial odontogenic tumor10.1IL10, SELE
40hemoglobinopathy10.1ALB, IL1B
41leukostasis10.1IL10, SELE
42dementia - subcortical10.0IL10, SELE
43metagonimiasis10.0CTSL, IL10
44bronchial disease10.0ALB, ALPP, GPT, SLC17A5
45sarcoid meningitis10.0ALB, IL10
46lymphedema10.0ALB, IL10, INS
47infancy electroclinical syndrome10.0IL10, IL1B
48benign lymphoepithelial lesion of salivary gland9.9ALB, IL1B
49burns9.9IL10, IL1B
50orbital lymphangioma9.9IL10, IL1B

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to fascioliasis

Symptoms for Fascioliasis

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Drugs & Therapeutics for Fascioliasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Fascioliasis


Cochrane evidence based reviews: fascioliasis

Genetic Tests for Fascioliasis

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Anatomical Context for Fascioliasis

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MalaCards organs/tissues related to Fascioliasis:

35
Liver, Lung, Testes, Brain, T cells, Endothelial, Skin

Animal Models for Fascioliasis or affiliated genes

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MGI Mouse Phenotypes related to Fascioliasis:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.8ALB, CP, IL10, INS, SELE

Publications for Fascioliasis

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Articles related to Fascioliasis:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Seroprevalence of Human Fascioliasis in Chaharmahal and Bakhtiyari Province, Southwestern Iran. (27648421)
2016
2
Human Fascioliasis: A Re-emerging Disease in Upper Egypt. (25870421)
2015
3
Investigation of the roles of fascioliasis and food allergy in intrahepatic eosinophilic proliferative pylephlebitis in Japanese Black cattle. (23131780)
2013
4
Sporadic incidence of Fascioliasis detected during hepatobiliary procedures: a study of 18 patients from Sulaimaniyah governorate. (23259859)
2012
5
Evaluation of a 14.5 kDa-Fasciola gigantica fatty acid binding protein as a diagnostic antigen for human fascioliasis. (22113304)
2012
6
Altered eosinophil proteome in a patient with hypereosinophilia from acute fascioliasis. (21955624)
2011
7
Ineffectiveness of myrrh-derivative Mirazid against schistosomiasis and fascioliasis in humans. (21218718)
2010
8
Bridging gaps in the molecular phylogeny of the Lymnaeidae (Gastropoda: Pulmonata), vectors of Fascioliasis. (21143890)
2010
9
Fascioliasis: can Cuba conquer this emerging parasitosis? (19910253)
2010
10
Treatment of human fascioliasis with triclabendazole: good news. (18346770)
2008
11
Chronic fascioliasis in farmed and wild greater rheas (Rhea americana). (17257760)
2007
12
Lipid peroxidation level and antioxidant enzyme activities in the blood of patients with acute and chronic fascioliasis. (16859944)
2007
13
Fascioliasis: a report of five cases presenting with common bile duct obstruction. (16421437)
2006
14
Geographical Information Systems risk assessment models for zoonotic fascioliasis in the South American Andes region. (16044684)
2005
15
Study of some immune aspects in patients with fascioliasis before and after Chommiphora molmol (Mirazid) treatment. (15125536)
2004
16
Hepatobiliary fascioliasis: clinical and radiologic features and endoscopic management. (15128078)
2004
17
Experimental fascioliasis in the rat-like hamster, Tscherskia triton, and other rodent hosts. (12798926)
2003
18
Role of circulating Fasciola antigens and IgG4 isotype in assessment of cure from fascioliasis. (14964667)
2003
19
High fascioliasis infection in children linked to a man-made irrigation zone in Peru. (11952950)
2002
20
Trace element levels in the liver of rats with acute and chronic fascioliasis and after treatment with zinc-copper hydroxochloride mixed crystals. (12018202)
2002
21
Soluble adhesion molecules as a marker of disease severity in human fascioliasis. (10946501)
2000
22
Hepatic fibrosis due to fascioliasis and/or schistosomiasis in Abis 1 village, Egypt. (12197343)
2000
23
Specific IgG avidity in acute and chronic human fascioliasis. (12197349)
2000
24
IgM and IgG cystatin capture enzyme linked immunosorbent assays: a tool for serodiagnosis and assessment of cure of acute fascioliasis after triclabendazole (TCZ; Fasinex) therapy. (11198366)
2000
25
Fascioliasis: US, CT, and MRI findings with new observations. (10926194)
2000
26
High endemicity of human fascioliasis between Lake Titicaca and La Paz valley, Bolivia. (10450437)
1999
27
Short report: Immunodiagnosis of human fascioliasis using recombinant Fasciola hepatica cathepsin L1 cysteine proteinase. (10344647)
1999
28
Human Fascioliasis in The Metropolitan Area of Curitiba, Brazil Evaluation of The Foci of Infection and Report of Nine Cases Treated With Triclabendazole. (11084672)
1999
29
The effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep. (9185081)
1997
30
Hepatic fascioliasis: case report and review. (8762643)
1996
31
Biliary fascioliasis: diagnosis, treatment and follow-up by ERCP. (8781945)
1996
32
Human fascioliasis in an Egyptian village: prevalence and some epidemiological determinants. (17214174)
1995
33
Aberrant fascioliasis: ectopic focus in peritoneal cavity. (7844436)
1994
34
Studies on serum beta-glucuronidase activity and urinary tryptophan metabolites in human fascioliasis. (8505768)
1993
35
Use of LANDSAT MSS imagery and soil type in a geographic information system to assess site-specific risk of fascioliasis on Red River Basin farms in Louisiana. (1626889)
1992
36
Hepatic fascioliasis and biliary surgery. (1399359)
1992
37
Epizootiology of fascioliasis in Montana. (1496783)
1992
38
Successful treatment of acute fascioliasis with bithionol. (1959855)
1991
39
Molluscicidal trials and correlation between the presence of Tetrapleura tetraptera in an area and the absence of the intermediate hosts of schistosomiasis and fascioliasis in southwest Nigeria. (2255208)
1990
40
Specificity of crude and purified Fasciola antigens in immunodiagnosis of human fascioliasis. (1692074)
1990
41
Sensitivity of crude and purified Fasciola antigens in immunological diagnosis of human fascioliasis. (2768848)
1989
42
Fascioliasis and hepatic affection. (3131442)
1988
43
Bithionol (Bitin) treatment in established fascioliasis in Egyptians. (3184244)
1988
44
Human fascioliasis: cure by mebendazole? A case report. (3758595)
1986
45
Incidence of experimental fascioliasis on hepatic disposition of [3H]tetracycline and [14C]rafoxanide in rats. (4067840)
1985
46
Laparoscopic findings in eight cases of liver fascioliasis. (3160576)
1985
47
Use of a partially purified Fasciola gigantica worm antigen in the serological diagnosis of human fascioliasis in Egypt. (6305221)
1983
48
Human fascioliasis in Israel. An imported case. (7263203)
1981
49
Chronic subclinical fascioliasis in sheep: effects on food intake, food utilisation and blood constituents. (7375735)
1980
50
Bovine fascioliasis in Nigeria. II. Blood chemistry and its correlation with worm burdens in chronicc fascioliasis. (7468004)
1980

Variations for Fascioliasis

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Expression for genes affiliated with Fascioliasis

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Search GEO for disease gene expression data for Fascioliasis.

Pathways for genes affiliated with Fascioliasis

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GO Terms for genes affiliated with Fascioliasis

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Cellular components related to Fascioliasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:00057648.9CTSL, IL1B, SLC17A5
2extracellular spaceGO:00056156.4ALB, CP, CTSL, GPT, IL10, IL1B

Biological processes related to Fascioliasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid catabolic processGO:00509959.8IL1B, INS
2positive regulation of cytokine secretionGO:00507159.7IL10, INS
3positive regulation of mitotic nuclear divisionGO:00458409.4IL1B, INS
4agingGO:00075688.7CP, IL10, IL1B
5response to lipopolysaccharideGO:00324968.6IL10, IL1B, SELE

Sources for Fascioliasis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet