MCID: FSC002
MIFTS: 54

Fascioliasis malady

Infectious diseases, Liver diseases categories

Summaries for Fascioliasis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as "the common liver fluke" or "the sheep liver fluke." A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all 5 continents, in over 50 countries, especially where sheep or cattle are reared. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The immature larval flukes migrate through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes, which produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards: Fascioliasis, also known as fasciola hepatica infection, is related to hepatitis and schistosomiasis. An important gene associated with Fascioliasis is SLC17A5 (solute carrier family 17 (acidic sugar transporter), member 5), and among its related pathways are Codeine and morphine metabolism and Ifosfamide Pathway, Pharmacokinetics. The compounds troleandomycin and aminopyrine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and testes.

Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by fasciola hepatica or fasciola gigantica. during the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Wikipedia:63 Fasciolosis also known as Fascioliasis, Fasciolasis, distomatosis and liver rot, is an important... more...

Aliases & Classifications for Fascioliasis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Liver diseases


Aliases & Descriptions:

fascioliasis 8 42 10 44 60
fasciola hepatica infection 8 60
sheep liver fluke infection 8
infection by fasciola 8
liver flukes nos 8


External Ids:

Disease Ontology8 DOID:885
ICD9CM27 121.3
MeSH34 D005211
ICD1025 B66.3

Related Diseases for Fascioliasis

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17GeneCards, 18GeneDecks
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Diseases related to Fascioliasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.0GUSB, SLC17A5, GGT1
2schistosomiasis30.8FABP12, GUSB, EPGN, RNASE3
3hepatitis a30.3GOT2
4hepatitis c30.3GOT2, GGT1, SLC17A5, CYP2A6
5pancreatitis30.3SLC17A5, GGT1, GOT2, ALPP
6opisthorchiasis30.2GGT1, EPGN
7obstructive jaundice29.8GGT1, ALPP
8cholestasis29.8SLC17A5, GGT1, GOT2, ALPP
9von hippel-lindau disease10.3
10peritonitis10.2
11paragonimiasis10.2
12dicrocoeliasis10.1
13clonorchiasis10.1
14cysticercosis10.0
15skin disease10.0ALPP
16autoimmune hepatitis10.0CYP2D7P1
17hypercholesterolemia10.0SLC17A5, GGT1
18neonatal hemochromatosis10.0SLC17A5, GGT1
19diarrhea10.0GOT2, ALPP
20extrahepatic cholestasis10.0GGT1, ALPP
21fatty liver disease10.0GGT1, GOT2
22substance abuse10.0GOT2, GGT1
23lung cancer10.0CYP2D7P1, CYP2A6
24sinusitis10.0RNASE3
25gallbladder disease10.0GOT2, GGT1
26parkinson's disease10.0CYP2D7P1
27intrahepatic cholestasis10.0ALPP, GGT1, SLC17A5
28biliary atresia10.0GGT1
29cholelithiasis10.0ALPP, GGT1, GUSB
30galactosemia10.0SLC17A5, GGT1, ALPP
31hypertension10.0GGT1, CYP2J2
32myocardial infarction10.0GOT2, FABP12
33primary biliary cirrhosis10.0SLC17A5, GGT1, ALPP
34alcoholic liver cirrhosis10.0CYP2A6, SLC17A5, GGT1
35choledocholithiasis10.0ALPP, GGT1, SLC17A5, GUSB
36congenital stationary night blindness, type 1f10.0GUSB, SLC17A5, GGT1, ALPP
37viral hepatitis10.0GGT1, SLC17A5, CYP2A6
38scrub typhus10.0SLC17A5
39periodontal disease10.0GUSB, SLC17A5, ALPP
40cholangitis10.0SLC17A5, GGT1, GOT2, ALPP
41leukopenia10.0ALPP, GOT2, SLC17A5, GUSB
42liver cirrhosis10.0ALPP, GGT1, SLC17A5, CYP2A6
43thrombocytopenia10.0GUSB, SLC17A5, GOT2, ALPP
44atherosclerosis10.0FABP12, CYP2B6, CYP2J2, GGT1
45diabetes mellitus10.0GGT1, GOT2, ALPP
46type 2 diabetes mellitus10.0GGT1, SLC17A5, GUSB, FABP12
47gilbert syndrome10.0UGT3A1, UGT3A2, UGT2A3, UGT2A1, UGT2B11
48cystic fibrosis10.0RNASE3, GUSB
49psoriasis10.0GUSB, RNASE3
50tuberculosis10.0CYP2B6, CYP2A6, GUSB

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to fascioliasis

Clinical Features for Fascioliasis

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Drugs & Therapeutics for Fascioliasis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Fascioliasis

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Anatomical Context for Fascioliasis

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32MalaCards
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MalaCards organs/tissues related to Fascioliasis:

32
Liver, Lung, Testes, T cells, Brain, Skin, Pancreas, Eye, Kidney, Colon, Spleen, Endothelial

Animal Models for Fascioliasis or affiliated genes

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Publications for Fascioliasis

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50PubMed
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Articles related to Fascioliasis:

(show top 50)    (show all 492)
idTitleAuthorsYear
1
Epidemiology of human fascioliasis and intestinal parasitosis among schoolchildren in Lake Tana Basin, northwest Ethiopia. (23843557)
2013
2
Domestically acquired fascioliasis in northern California. (23836562)
2013
3
Application of a geographical information system approach for risk analysis of fascioliasis in southern EspiI8rito Santo state, Brazil. (23032288)
2012
4
Extra-hepatic fascioliasis with peritoneal malignancy tumor feature. (23542770)
2012
5
Cases of human fascioliasis in India: tip of the iceberg. (22718061)
2012
6
Fascioliasis: 3 cases with three different clinical presentations. (22798118)
2012
7
Human fascioliasis in Argentina: retrospective overview, critical analysis and baseline for future research. (21663691)
2011
8
Diagnostic imaging in the study of human hepatobiliary fascioliasis. (20012922)
2010
9
Biliary fascioliasis: sonographic appearance patterns. (18642366)
2009
10
Fascioliasis in pregnancy. (18669773)
2008
11
Biochemical parameters in chronic fascioliasis. (19209779)
2008
12
Biliary parasitic diseases including clonorchiasis, opisthorchiasis and fascioliasis. (17934771)
2008
13
Zoonotic fascioliasis in donkeys: ELISA (Fges) and postmortum examination in the Zoo, Giza, Egypt. (18383809)
2007
14
Treatment of fascioliasis in human infections. (16260013)
2006
15
HCV/PCR positivity in bile and doudenal aspiration of fascioliasis and/or HCV patients. (17153695)
2006
16
Cutaneous fascioliasis: a case report in Vietnam. (15891121)
2005
17
Serodiagnosis of human fascioliasis by a cystatin capture enzyme-linked immunosorbent assay with recombinant Fasciola gigantica cathepsin L antigen. (15728871)
2005
18
Usefulness of 8 kDa protein of Fasciola hepatica in diagnosis of fascioliasis. (12815325)
2003
19
Biliary fascioliasis: case report and review of the literature. (12841316)
2002
20
Fascioliasis among live and slaugthered animals in nine centers of Dakahlia Governorate. (12049269)
2002
21
Immunodiagnosis of human fascioliasis by an enzyme-linked immunosorbent assay (ELISA) and a micro-ELISA. (11139214)
2001
22
Clinico-epidemiological study of human fascioliasis in an endemic focus in Dakahlia Governorate, Egypt. (11775099)
2001
23
Hepatic fibrosis due to fascioliasis and/or schistosomiasis in Abis 1 village, Egypt. (12197343)
2000
24
New opportunities for the control of fascioliasis. (10327707)
1999
25
Short report: Immunodiagnosis of human fascioliasis using recombinant Fasciola hepatica cathepsin L1 cysteine proteinase. (10344647)
1999
26
Human fascioliasis in Egyptian children: successful treatment with triclabendazole. (10401189)
1999
27
Fascioliasis: sonographic abnormalities of the biliary tract and evolution after treatment with triclabendazole. (10588772)
1999
28
Successful treatment of human fascioliasis with triclabendazole. (10482035)
1999
29
A population-based coprological study of human fascioliasis in a hyperendemic area of the Bolivian Altiplano. (9270738)
1997
30
SSU rDNA characterization of lymnaeid snails transmitting human fascioliasis in South and Central America. (9406784)
1997
31
MR findings in human fascioliasis. (8673841)
1996
32
Human fascioliasis in an Egyptian village: prevalence and some epidemiological determinants. (17214174)
1995
33
Hepatic fascioliasis: CT findings. (7863918)
1995
34
Serodifferentiation of human fascioliasis from schistosomiasis. (7855923)
1994
35
Efficacy of glutathione for treatment of fascioliasis. An investigation in the experimentally infested rat. (8494576)
1993
36
Trematode infections. Opisthorchiasis, clonorchiasis, fascioliasis, and paragonimiasis. (8254167)
1993
37
Early immunodiagnosis of bovine fascioliasis using the specific antigen f2 in a passive hemagglutination test. (1279885)
1992
38
Human fascioliasis: a parasitic health problem in Dakahlia Governorate, Egypt. (1875080)
1991
39
Bithionol (Bitin) treatment in established fascioliasis in Egyptians. (3184244)
1988
40
Human fascioliasis treated with triclabendazole (Fasinex) for the first time. (3252594)
1988
41
A short note on praziquantel in human fascioliasis. (3773022)
1986
42
Some biochemical indices in naturally occurring fascioliasis in goats. (3704349)
1986
43
Human fascioliasis in Cajamarca/Peru. I. Diagnostic methods and treatment with praziquantel. (4023557)
1985
44
Studies on fascioliasis in four selected sites in Ethiopia. (4049725)
1985
45
Bacterial infection of the common bile duct in chronic fascioliasis in the rat. (6736306)
1984
46
Fascioliasis problems in ruminants in Rio Grande do Sul, Brazil. (6891851)
1982
47
Further studies in the control of ovine fascioliasis by strategic dosing. (7336552)
1981
48
Comparative automated assay of anti-P1 antibodies in acute hepatic distomiasis (fascioliasis) and in hydatidosis. (7385756)
1980
49
Perilobular fibrosis in chronic bovine fascioliasis. (432878)
1979
50
Studies on the pathology of dicrocoeliasis and fascioliasis in the goat. 3. The histochemistry of mast cells and globule leucocytes. (4118525)
1972

Genetic Variations for Fascioliasis

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Expression for genes affiliated with Fascioliasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fascioliasis

Search GEO for disease gene expression data for Fascioliasis.

Pathways for genes affiliated with Fascioliasis

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 12EMD Millipore, 53Reactome
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Pathways related to Fascioliasis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2CYP2D7P1, CYP2B6
2
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10.2CYP2A6, CYP3A5
3
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10.2CYP2A6, CYP2B6
4
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10.1CYP2A6, CYP4X1
5
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10.1CYP2A6, CYP4X1
610.1CYP3A43, CYP3A5, CYP2J2
7
Retinol metabolism
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10.0CYP2B6, CYP2A6, CYP3A5
8
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10.0CYP3A5, CYP2A6, CYP2B6
9
Hide members
10.0GGT1, CYP2J2, CYP2B6
10
Hide members
10.0CYP2B6, CYP3A5, UGT2B11
11
Hide members
10.0CYP4X1, CYP2A6, CYP2B6
12
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9.8CYP3A43, CYP3A5, CYP2A6, CYP2B6, CYP2J2
13
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9.6CYP2J2, CYP2B6, CYP2A6, CYP4X1, CYP3A5, CYP3A43
14
Hide members
9.5GUSB, UGT2A3, UGT2A1, UGT2B11, CYP3A43, CYP3A5
15
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9.5UGT2A3, UGT2A1, UGT2B11, CYP3A43, CYP3A5, CYP2A6
16
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9.2GUSB, UGT2A3, UGT2A1, UGT2B11, CYP3A43, CYP3A5
17
Hide members
9.0GGT1, UGT2A3, UGT2A1, UGT2B11, CYP3A43, CYP3A5

Compounds for genes affiliated with Fascioliasis

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Fascioliasis according to GeneCards/GeneDecks:

(show top 50)    (show all 179)
idCompoundScoreTop Affiliating Genes
1troleandomycin44 1111.3CYP2A6, CYP3A43, CYP3A5, CYP2B6
2aminopyrine4410.3GGT1, SLC17A5, CYP2B6, CYP2A6
3praziquantel44 1111.3CYP3A5, GGT1, RNASE3, CYP3A43
4bilirubin diglucuronide44 2411.3UGT2A1, UGT2B11, UGT2A3, GUSB
5(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)2410.3UGT2A3, UGT2A1, GUSB, UGT2B11
6aldosterone 18-glucuronide44 2411.2UGT2A1, UGT2A3, GUSB, UGT2B11
7androsterone glucuronide44 2411.2UGT2A1, UGT2B11, GUSB, UGT2A3
8buprenorphine44 28 1112.2SLC17A5, CYP2A6, GUSB, CYP3A5
9azelastine44 1111.2CYP2B6, CYP3A5, CYP2A6, RNASE3
103-alpha-androstanediol glucuronide44 2411.2UGT2A1, UGT2B11, UGT2A3, GUSB
11aflatoxin b144 2411.2CYP2B6, CYP3A5, CYP2A6, SLC17A5
12chlorzoxazone44 28 1112.2GUSB, CYP2A6, CYP3A5, SLC17A5, CYP2B6
13rifampin49 1111.2CYP2A6, CYP3A5, CYP3A43, CYP2B6
14antipyrine44 1111.2CYP2B6, GUSB, CYP2A6, SLC17A5, GGT1
15nevirapine44 49 1112.2CYP2A6, CYP2B6, SLC17A5, GGT1, CYP3A5
16sevoflurane44 1111.1SLC17A5, GGT1, CYP2A6, CYP2B6, ALPP
17rifampicin44 28 5912.1CYP2B6, SLC17A5, GGT1, CYP3A5, CYP2A6
18isoflurane44 1111.1ALPP, GGT1, CYP2B6, SLC17A5
19lidocaine44 28 1112.1CYP3A5, CYP2A6, CYP2B6, SLC17A5
20carbamazepine44 49 1112.1CYP2B6, CYP3A5, ALPP, GGT1, SLC17A5
21erythromycin44 49 2 1113.1CYP3A5, CYP2A6, CYP2B6, GUSB, ALPP
22phenytoin44 49 28 1113.0CYP2A6, CYP3A5, CYP2B6, SLC17A5, GGT1, ALPP
236-hydroxymelatonin44 28 2412.0CYP3A5, CYP2J2, CYP2B6, CYP2A6, CYP4X1, CYP3A43
24paraxanthine44 2411.0CYP2B6, CYP2J2, CYP3A43, CYP3A5, CYP4X1, CYP2A6
25Formic Acid11 2411.0CYP3A43, CYP3A5, CYP2A6, CYP2B6, CYP4X1, CYP2J2
26parathion44 2411.0CYP3A43, CYP2A6, CYP4X1, CYP2B6, CYP2J2, CYP3A5
27citalopram49 44 11 2413.0CYP3A5, CYP2A6, CYP2J2, CYP2B6, CYP4X1, CYP3A43
28disulfiram44 59 1112.0GGT1, CYP2A6, SLC17A5, CYP3A5
29androstenedione44 2411.0CYP2A6, CYP3A5, CYP3A43, CYP2B6, CYP2J2, CYP4X1
30linoleic acid44 28 2412.0CYP4X1, CYP2J2, CYP2B6, CYP2A6, CYP3A5, CYP3A43
31caffeine44 49 28 2 11 2414.9CYP2A6, CYP3A43, CYP3A5, CYP2B6, CYP2J2, CYP4X1
32benzphetamine44 1110.9GUSB, CYP2B6, CYP2A6
33vitamin b12449.9GUSB, SLC17A5, GGT1, ALPP
34verapamil44 49 28 11 2413.9ALPP, CYP3A5, CYP2B6, SLC17A5, GGT1
35phenobarbital44 28 1111.9ALPP, GUSB, CYP3A5, CYP2A6, CYP2B6, SLC17A5
36heme28 11 2411.9CYP3A43, CYP2A6, CYP3A5, CYP4X1, CYP2B6, CYP2J2
37quercetin44 59 11 2412.9ALPP, GUSB, CYP2B6, GGT1, CYP2A6, UGT3A1
38formaldehyde44 2410.8CYP3A5, CYP3A43, CYP2A6, RNASE3, CYP2J2, CYP4X1
39phenacetin44 1110.7CYP2B6, CYP2A6, CYP3A5
40valproic acid44 49 11 2412.7GGT1, CYP2J2, CYP2B6, CYP2A6, CYP4X1, CYP3A5
41tamoxifen44 49 28 1112.7CYP2B6, CYP3A5, ALPP, GGT1, CYP2A6, SLC17A5
42arachidonic acid44 28 11 2412.6CYP2A6, CYP3A43, CYP3A5, CYP4X1, CYP2B6, CYP2J2
43creatinine449.6GUSB, FABP12, ALPP, GGT1, SLC17A5, CYP3A5
44estrone44 28 11 2412.6UGT2B11, UGT2A1, UGT2A3, CYP3A43, CYP3A5, CYP2J2
45nadph44 2410.6CYP3A5, CYP4X1, CYP2A6, CYP2J2, CYP2B6, CYP3A43
46estradiol44 11 2411.6UGT2B11, CYP2J2, CYP2B6, CYP2A6, CYP4X1, CYP3A5
47dexamethasone44 49 28 1112.5ALPP, GGT1, RNASE3, CYP2B6, CYP2A6, CYP3A43
48codeine44 49 28 11 2413.4CYP2A6, UGT2A1, UGT2A3, CYP2B6, GUSB, CYP4X1
49testosterone44 59 11 2412.1CYP3A5, CYP4X1, GGT1, SLC17A5, CYP2B6, CYP2A6
50retinoic acid44 2410.1ALPP, RNASE3, CYP2J2, CYP2B6, CYP3A43, CYP2A6

GO Terms for genes affiliated with Fascioliasis

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16Gene Ontology
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Cellular components related to Fascioliasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:0057899.4CYP2J2, CYP2B6, CYP2A6, CYP4X1, CYP3A5, CYP3A43

Biological processes related to Fascioliasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular glucuronidationGO:05269510.2UGT2A1, UGT2A3
2steroid metabolic processGO:0082029.9CYP3A5, CYP2A6, CYP2B6
3exogenous drug catabolic processGO:0427389.9CYP2B6, CYP2A6
4xenobiotic metabolic processGO:0068059.5GGT1, UGT2B11, CYP3A43, CYP3A5, CYP2A6, CYP2B6
5small molecule metabolic processGO:0442819.2GUSB, CYP3A43, CYP3A5, CYP2A6, CYP2B6, CYP2J2

Molecular functions related to Fascioliasis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:01671210.2CYP2B6, CYP2A6
2monooxygenase activityGO:00449710.0CYP3A43, CYP3A5, CYP2B6
3aromatase activityGO:0703309.9CYP2J2, CYP4X1, CYP3A5, CYP3A43
4glucuronosyltransferase activityGO:0150209.8UGT2B11, UGT2A1, UGT2A3, UGT3A2, UGT3A1
5UDP-glycosyltransferase activityGO:0081949.8UGT3A2, UGT3A1
6heme bindingGO:0200379.7CYP3A43, CYP3A5, CYP4X1, CYP2A6, CYP2B6, CYP2J2
7iron ion bindingGO:0055069.7CYP3A43, CYP3A5, CYP4X1, CYP2A6, CYP2B6, CYP2J2
8electron carrier activityGO:0090559.6CYP3A43, CYP3A5, CYP4X1, CYP2A6, CYP2B6, CYP2J2

Products for genes affiliated with Fascioliasis

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  • Antibodies
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Sources for Fascioliasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet