MCID: FSC002
MIFTS: 42

Fascioliasis malady

Rare diseases, Infectious diseases, Liver diseases categories

Aliases & Classifications for Fascioliasis

About this section

Aliases & Descriptions for Fascioliasis:

Name: Fascioliasis 10 45 47 12 2 65 36
Fasciola Hepatica Infection 10 65
Sheep Liver Fluke Infection 10
 
Infection by Fasciola 10
Liver Flukes Nos 10


Classifications:



External Ids:

Disease Ontology10 DOID:885
MeSH36 D005211
ICD9CM29 121.3
ICD1027 B66.3

Summaries for Fascioliasis

About this section
CDC:2 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as "the common liver fluke" or "the sheep liver fluke." A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all 5 continents, in over 50 countries, especially where sheep or cattle are reared. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The immature larval flukes migrate through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes, which produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards based summary: Fascioliasis, also known as fasciola hepatica infection, is related to hepatitis and opisthorchiasis. An important gene associated with Fascioliasis is ALPP (Alkaline Phosphatase, Placental), and among its related pathways are OX40 Pathway and ATF-2 transcription factor network. Affiliated tissues include liver, lung and testes, and related mouse phenotypes are normal and liver/biliary system.

Disease Ontology:10 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by fasciola hepatica or fasciola gigantica. during the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Related Diseases for Fascioliasis

About this section

Diseases related to Fascioliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.0IFNG, IL10, SLC17A5
2opisthorchiasis30.3IFNG, IL10
3cholestasis30.0ALB, ALPP, GPT
4hemolytic anemia29.9IFNG, IL10
5schistosomiasis10.7
6peritonitis10.3
7paragonimiasis10.3
8pancreatitis10.3
9mononeuritis multiplex10.2ALPP, CP
10methanol poisoning10.2GPT, SLC17A5
11gallbladder endocrine tumor10.2ALPP, GPT
12pyruvate kinase deficiency, liver type10.2GPT, SLC17A5
13adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency10.2GPT, SLC17A5
14toxic labyrinthitis10.2CP, SELE
15graphite pneumoconiosis10.2CP, INS
16casp10-related autoimmune lymphoproliferative syndrome10.2INS, SELE
17hepatitis c virus10.2
18dicrocoeliasis10.2
19clonorchiasis10.2
20hepatitis c10.2
21eosinophilia10.2
22patent foramen ovale10.2ALPP, GPT
23humero-ulnar synostosis10.2IL1B, SLC17A5
24hepatic encephalopathy10.2CP, GPT
25thelaziasis10.2ALB, ALPP
26gender identity disorder10.2ALB, ALPP
27acinic cell breast carcinoma10.2ALB, ALPP
28abnormal pupillary function10.2ALB, ALPP
29endogenous depression10.2ALB, ALPP
30mini stroke10.2ALB, CP
31axial osteomalacia10.2ALB, ALPP
32congenital cataract - progressive muscular hypotonia - hearing loss - developmental delay10.2IL1B, SELE
33pes anserinus tendinitis or bursitis10.1GPT, IL1B
34cholangiocarcinoma10.1
35cysticercosis10.1
36complement deficiency10.1ALB, SLC17A5
37acute endometritis10.1IL10, IL1B
38nondystrophic myotonia10.1GPT, INS, SLC17A5
39occupational dermatitis10.1ALB, ALPP
40hepatoblastoma10.1ALB, ALPP
41prostatic cyst10.1ALB, ALPP
42retinitis pigmentosa 1710.1ALB, INS
43pseudovascular skin squamous cell carcinoma10.1GPT, INS, SLC17A5
44gallbladder sarcoma10.1ALPP, IL10, INS
45clear cell squamous cell skin carcinoma10.1ALB, INS
46spastic hemiplegia10.1ALB, IL10
47hyperthyroxinemia10.1ALB, IL1B
48autoimmune polyendocrine syndrome10.1ALB, ALPP
49endophthalmitis10.1IL1B, SELE, SLC17A5
50hordeolum10.1IFNG, SLC17A5

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to fascioliasis

Symptoms for Fascioliasis

About this section

Drugs & Therapeutics for Fascioliasis

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Fascioliasis


Cochrane evidence based reviews: Fascioliasis

Genetic Tests for Fascioliasis

About this section

Anatomical Context for Fascioliasis

About this section

MalaCards organs/tissues related to Fascioliasis:

33
Liver, Lung, Testes, Brain, T cells, Endothelial, Skin

Animal Models for Fascioliasis or affiliated genes

About this section

MGI Mouse Phenotypes related to Fascioliasis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.9ALB, ALPP, IFNG, IL10, INS, SELE
2MP:00053707.8ALB, CP, IFNG, IL10, INS, SELE
3MP:00053917.5CP, IFNG, IL10, INS, SELE, SLC17A5
4MP:00053847.4ALB, CP, IFNG, IL10, INS, SELE
5MP:00053857.3CP, IFNG, IL10, IL1B, INS, SELE
6MP:00107686.7ALB, ALPP, IFNG, IL10, IL1B, INS
7MP:00053766.6ALB, CP, IFNG, IL10, IL1B, INS

Publications for Fascioliasis

About this section

Articles related to Fascioliasis:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Fascioliasis: An Ongoing Zoonotic Trematode Infection. (26417603)
2015
2
Human Fascioliasis: A Re-emerging Disease in Upper Egypt. (25870421)
2015
3
Fascioliasis diagnosed by EUS and ERCP. (23987576)
2013
4
Application of a geographical information system approach for risk analysis of fascioliasis in southern EspiI8rito Santo state, Brazil. (23032288)
2012
5
Sporadic incidence of Fascioliasis detected during hepatobiliary procedures: a study of 18 patients from Sulaimaniyah governorate. (23259859)
2012
6
Evaluation of a 14.5 kDa-Fasciola gigantica fatty acid binding protein as a diagnostic antigen for human fascioliasis. (22113304)
2012
7
Lymnaea schirazensis, an overlooked snail distorting fascioliasis data: genotype, phenotype, ecology, worldwide spread, susceptibility, applicability. (21980347)
2011
8
Hyperendemic human fascioliasis in Andean valleys: an altitudinal transect analysis in children of Cajamarca province, Peru. (21767521)
2011
9
Hepatobiliary fascioliasis: a case with unusual radiological features. (19813166)
2010
10
Ineffectiveness of myrrh-derivative Mirazid against schistosomiasis and fascioliasis in humans. (21218718)
2010
11
Chapter 2. Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control. (19622408)
2009
12
Treatment of human fascioliasis with triclabendazole: good news. (18346770)
2008
13
Screening for Indian isolates of egg-parasitic fungi for use in biological control of fascioliasis and amphistomiasis in ruminant livestock. (18462555)
2008
14
Effect of Fascioliasis on the pharmacokinetic parameters of triclabendazole in human subjects. (17265093)
2007
15
Evaluation of immunoglobulin G4 subclass antibody in a peptide-based enzyme-linked immunosorbent assay for the serodiagnosis of human fascioliasis. (17714604)
2007
16
Immune suppression in advanced chronic fascioliasis: an experimental study in a rat model. (17436231)
2007
17
Unusual thrombotic manifestations secondary to antiphospholipid syndrome and hepatic fascioliasis. (15908004)
2006
18
Eight cases of fascioliasis: clinical and microbiological features. (16309872)
2006
19
Geographical Information Systems risk assessment models for zoonotic fascioliasis in the South American Andes region. (16044684)
2005
20
Study of some immune aspects in patients with fascioliasis before and after Chommiphora molmol (Mirazid) treatment. (15125536)
2004
21
Clinical signs and household characteristics associated with human fascioliasis among rural population in Egypt: a case-control study. (15270537)
2003
22
Molecular phylogenetic relationships in the aquatic snail genus Lymnaea, the intermediate host of the causative agent of fascioliasis: insights from broader taxon sampling. (12107463)
2002
23
Hepatic fascioliasis in the Americas: A new challenge for therapeutic endoscopy. (12145622)
2002
24
Soluble adhesion molecules as a marker of disease severity in human fascioliasis. (10946501)
2000
25
Hepatic fibrosis due to fascioliasis and/or schistosomiasis in Abis 1 village, Egypt. (12197343)
2000
26
Specific IgG avidity in acute and chronic human fascioliasis. (12197349)
2000
27
IgM and IgG cystatin capture enzyme linked immunosorbent assays: a tool for serodiagnosis and assessment of cure of acute fascioliasis after triclabendazole (TCZ; Fasinex) therapy. (11198366)
2000
28
New opportunities for the control of fascioliasis. (10327707)
1999
29
Circulating antibodies and antigens correlate with egg counts in human fascioliasis. (10583903)
1999
30
High endemicity of human fascioliasis between Lake Titicaca and La Paz valley, Bolivia. (10450437)
1999
31
Short report: Immunodiagnosis of human fascioliasis using recombinant Fasciola hepatica cathepsin L1 cysteine proteinase. (10344647)
1999
32
Evaluation of IHA test for fascioliasis in cases of hepatitis C virus infection. (8754655)
1996
33
Human fascioliasis in an Egyptian village: prevalence and some epidemiological determinants. (17214174)
1995
34
Intraocular fascioliasis: a case report. (8147493)
1994
35
Aberrant fascioliasis: ectopic focus in peritoneal cavity. (7844436)
1994
36
Radiological findings of human fascioliasis. (8508088)
1993
37
Use of LANDSAT MSS imagery and soil type in a geographic information system to assess site-specific risk of fascioliasis on Red River Basin farms in Louisiana. (1626889)
1992
38
Fascioliasis. (1419568)
1992
39
Decrease in albendazole sulphonation during experimental fascioliasis in sheep. (1776267)
1991
40
Molluscicidal trials and correlation between the presence of Tetrapleura tetraptera in an area and the absence of the intermediate hosts of schistosomiasis and fascioliasis in southwest Nigeria. (2255208)
1990
41
Sensitivity of crude and purified Fasciola antigens in immunological diagnosis of human fascioliasis. (2768848)
1989
42
Fascioliasis and hepatic affection. (3131442)
1988
43
A short note on praziquantel in human fascioliasis. (3773022)
1986
44
Incidence of experimental fascioliasis on hepatic disposition of [3H]tetracycline and [14C]rafoxanide in rats. (4067840)
1985
45
Impairment of drug metabolism by the liver in experimental fascioliasis in the rat. (6139454)
1983
46
Use of a partially purified Fasciola gigantica worm antigen in the serological diagnosis of human fascioliasis in Egypt. (6305221)
1983
47
Fascioliasis in beef cattle in north-west Argentina. (7123667)
1982
48
Ecological basis of parasite control: trematodes with special reference to fascioliasis. (6891528)
1982
49
A three-year study of Lymnaea truncatula habitats, disease foci of fascioliasis. (7284746)
1981
50
Human fascioliasis in Israel. An imported case. (7263203)
1981

Variations for Fascioliasis

About this section

Expression for genes affiliated with Fascioliasis

About this section
Search GEO for disease gene expression data for Fascioliasis.

Pathways for genes affiliated with Fascioliasis

About this section

GO Terms for genes affiliated with Fascioliasis

About this section

Cellular components related to Fascioliasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056156.9ALB, CP, IFNG, IL10, IL1B, INS

Biological processes related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytokine secretionGO:00507159.9IL10, INS
2negative regulation of lipid catabolic processGO:00509959.9IL1B, INS
3positive regulation of MHC class II biosynthetic processGO:00453489.6IFNG, IL10
4positive regulation of calcidiol 1-monooxygenase activityGO:00605599.6IFNG, IL1B
5positive regulation of chemokine biosynthetic processGO:00450809.5IFNG, IL1B
6positive regulation of membrane protein ectodomain proteolysisGO:00510449.5IFNG, IL1B
7defense response to protozoanGO:00428329.5IFNG, IL10
8positive regulation of interleukin-6 biosynthetic processGO:00454109.5IFNG, IL1B
9positive regulation of mitotic nuclear divisionGO:00458409.4IL1B, INS
10negative regulation of growth of symbiont in hostGO:00441309.4IFNG, IL10
11response to lipopolysaccharideGO:00324969.0IL10, IL1B, SELE
12regulation of insulin secretionGO:00507969.0IFNG, IL1B, INS
13cellular response to lipopolysaccharideGO:00712228.6IFNG, IL10, IL1B
14positive regulation of nitric oxide biosynthetic processGO:00454298.5IFNG, IL1B, INS

Molecular functions related to Fascioliasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.5IFNG, IL10, IL1B

Sources for Fascioliasis

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet