MCID: FSC002
MIFTS: 38

Fascioliasis malady

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Fascioliasis

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Aliases & Descriptions for Fascioliasis:

Name: Fascioliasis 11 48 50 2 39 13 68
Fasciola Hepatica Infection 11 68
Sheep Liver Fluke Infection 11
 
Infection by Fasciola 11
Liver Flukes Nos 11

Classifications:



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Disease Ontology11 DOID:885
ICD1030 B66.3
ICD9CM32 121.3
MeSH39 D005211

Summaries for Fascioliasis

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CDC:2 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as "the common liver fluke" or "the sheep liver fluke." A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all 5 continents, in over 50 countries, especially where sheep or cattle are reared. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The immature larval flukes migrate through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes, which produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards based summary: Fascioliasis, also known as fasciola hepatica infection, is related to oral erosive lichen and acute lymphocytic leukemia. An important gene associated with Fascioliasis is SLC17A5 (Solute Carrier Family 17 Member 5), and among its related pathways are IL-10 Pathway and Cytokines and Inflammatory Response. Affiliated tissues include liver, lung and testes, and related mouse phenotype liver/biliary system.

Disease Ontology:11 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Related Diseases for Fascioliasis

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Diseases related to Fascioliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1oral erosive lichen10.6GPT, SLC17A5
2acute lymphocytic leukemia10.5GPT, SLC17A5
3fraxf syndrome10.5ALPP, GPT
4pancreatic solid pseudopapillary carcinoma10.5ALB, SLC17A5
5postinflammatory pulmonary fibrosis10.5CP, GPT
6multiple system atrophy with orthostatic hypotension10.5ALB, CP
7fibrous histiocytoma10.4ALB, GPT
8hole retinal cyst10.4ALB, INS
9constrictive pericarditis10.4ALB, INS
10antidepressant type abuse10.4ALB, INS
11conjunctival vascular disease10.4ALB, INS
12hepatitis10.3
13agammaglobulinemia 610.3ALB, INS
14paranasal sinus cancer, adult10.3CP, INS
15mastocytosis cutaneous with short stature conductive hearing loss and microtia10.3GPT, IL10
16spastic monoplegia10.3ALB, IL10
17alveolar periostitis10.3ALB, GPT, SLC17A5
18hepatic coma10.3ALB, GPT, SLC17A5
19pancreatic vasoactive intestinal peptide producing tumor10.3ALB, INS
20duodenal disease10.3ALB, ALPP, GPT
21intraorbital meningioma10.3ALB, GPT
22smooth muscle tumor10.3ALB, IL10
2310.3ALB, IL10
24extrahepatic cholestasis10.3ALB, ALPP, GPT
25schistosomiasis10.2
26chromoblastomycosis10.2ALB, SELE
27acquired gastric outlet stenosis10.2CP, SELE
28nondystrophic myotonia10.2GPT, INS, SLC17A5
29silver-russell syndrome due to 7p11.2p13 microduplication10.2IL1B, SLC17A5
30extrapulmonary tuberculosis10.2CTSL, IL10
31urinary bladder posterior wall cancer10.2ALB, CP, GPT
32casr-related disorders10.2INS, SELE
33spinocerebellar ataxia 810.2ALB, CP, GPT
34midline interhemispheric variant of holoprosencephaly10.1IL1B, SLC17A5
35pontocerebellar hypoplasia10.1IL10, INS
36labyrinthine bilateral reactive loss10.1INS, SELE
37plantar wart10.1GPT, IL1B
38alopecia10.1ALB, IL10
39calcifying epithelial odontogenic tumor10.1IL10, SELE
40hemoglobinopathy10.1ALB, IL1B
41leukostasis10.1IL10, SELE
42dementia - subcortical10.0IL10, SELE
43metagonimiasis10.0CTSL, IL10
44bronchial disease10.0ALB, ALPP, GPT, SLC17A5
45sarcoid meningitis10.0ALB, IL10
46lymphedema10.0ALB, IL10, INS
47infancy electroclinical syndrome10.0IL10, IL1B
48benign lymphoepithelial lesion of salivary gland9.9ALB, IL1B
49burns9.9IL10, IL1B
50orbital lymphangioma9.9IL10, IL1B

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to fascioliasis

Symptoms & Phenotypes for Fascioliasis

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MGI Mouse Phenotypes related to Fascioliasis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.8ALB, CP, IL10, INS, SELE

Drugs & Therapeutics for Fascioliasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Fascioliasis


Cochrane evidence based reviews: fascioliasis

Genetic Tests for Fascioliasis

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Anatomical Context for Fascioliasis

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MalaCards organs/tissues related to Fascioliasis:

36
Liver, Lung, Testes, Brain, T cells, Endothelial, Skin

Publications for Fascioliasis

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Articles related to Fascioliasis:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Seroprevalence of Human Fascioliasis in Chaharmahal and Bakhtiyari Province, Southwestern Iran. (27648421)
2016
2
First Report of Human Fascioliasis in an Endemic Region of Bovine Fascioliasis in Caldas-Colombia. (27045315)
2016
3
Treatment Failure after Multiple Courses of Triclabendazole among Patients with Fascioliasis in Cusco, Peru: A Case Series. (26808543)
2016
4
Animal Fascioliasis: Perspectives from high altitudinal regions. (27890078)
2016
5
Evaluation of modified Dennis parasitological technique for diagnosis of bovine fascioliasis. (27622626)
2016
6
Evaluation of patients diagnosed with fascioliasis: A six-year experience at a university hospital in Turkey. (27131001)
2016
7
Development of Two FhSAP2 Recombinant-Based Assays for Immunodiagnosis of Human Chronic Fascioliasis. (27549636)
2016
8
A pediatric case of Fascioliasis with eosinophilic pneumonia. (27922247)
2016
9
Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in blood samples diagnosed in Medic Medical Center Laboratory, Ho Chi Minh City, Vietnam in 2012. (27595647)
2016
10
Human fascioliasis endemic areas in Argentina: multigene characterisation of the lymnaeid vectors and climatic-environmental assessment of the transmission pattern. (27229862)
2016
11
Epidemiological analysis of human fascioliasis in northeastern Punjab, Pakistan. (26763724)
2016
12
Human Fascioliasis: A Re-emerging Disease in Upper Egypt. (25870421)
2015
13
Endoscopic Extraction of Biliary Fascioliasis Diagnosed Using Intraductal Ultrasonography in a Patient with Acute Cholangitis. (26668810)
2015
14
Education and imaging. Hepatology: Fascioliasis: a rare cause of hepatic pseudoaneurysmal rupture. (25536460)
2015
15
The Status of Human and Animal Fascioliasis in Iran: A Narrative Review Article. (26622287)
2015
16
Fascioliasis simulating an intrahepatic cholangiocarcinoma-Case report with imaging and pathology correlation. (25713810)
2015
17
Fascioliasis in Australian travellers to Bali. (26268290)
2015
18
Screening for Zoonotic Fascioliasis in Slaughtered Large Ruminants in Abattoirs in Perak, Malaysia. (26868715)
2015
19
Pathology in practice. Distomiasis (fascioliasis) in a New Mexico Dahl sheep. (26043127)
2015
20
Biochemical assessment of oxidative status versus liver enzymes in patients with chronic fascioliasis. (26688624)
2015
21
Biliary Fascioliasis Diagnosed on EUS. (26394385)
2015
22
A Case of Fascioliasis Treated Successfully Without Sequelae in a Japanese Expatriate Living in Jakarta. (26309420)
2015
23
Performance of a 27 kDa Fasciola hepatica Antigen in the Diagnosis of Human Fascioliasis. (25949054)
2015
24
Diagnosis of human fascioliasis in Arusha region, northern Tanzania by microscopy and clinical manifestations in patients. (26695775)
2015
25
Fascioliasis: An Ongoing Zoonotic Trematode Infection. (26417603)
2015
26
Epidemiology of Human Fascioliasis and Intestinal Helminthes in Rural Areas of Boyer-Ahmad Township, Southwest Iran; A Population Based Study. (26744710)
2015
27
The Endemicity of Human Fascioliasis in Guilan Province, Northern Iran: the Baseline for Implementation of Control Strategies. (26056669)
2015
28
Familial Trichostrongylus Infection Misdiagnosed as Acute Fascioliasis. (26402161)
2015
29
Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children. (26312936)
2015
30
Seroprevalence of human fascioliasis in Van province, Turkey. (26006203)
2015
31
Access to, and use of, water by populations living in a schistosomiasis and fascioliasis co-endemic area of northern CA'te d'Ivoire. (26004285)
2015
32
Developing a climate-based risk map of fascioliasis outbreaks in Iran. (25982974)
2015
33
CLINICOPATHOLOGIC CORRELATES OF FASCIOLIASIS IN TWO EASTERN GREY KANGAROOS (MACROPUS GIGANTEUS). (26667560)
2015
34
Fascioliasis and eosinophilia in the highlands of cuzco, peru and their association with water and socioeconomic factors. (25200257)
2014
35
Severe iron deficiency anemia and marked eosinophilia in adolescent girls with the diagnosis of human fascioliasis. (25341606)
2014
36
Diagnosis of human fascioliasis by stool and blood techniques: update for the present global scenario. (25077569)
2014
37
Finding of biliary fascioliasis by endoscopic ultrasonography in a patient with eosinophilic liver abscess. (25473389)
2014
38
Sonographic findings of hepatobiliary fascioliasis accompanied by extrahepatic expansion and ectopic lesions. (25425366)
2014
39
Distribution and abundance of schistosomiasis and fascioliasis host snails along the Mara River in Kenya and Tanzania. (25405008)
2014
40
Fasciola gigantica transmission in the zoonotic fascioliasis endemic lowlands of Guilan, Iran: experimental assessment. (25095734)
2014
41
An incidental case of biliary fascioliasis mimicking cholangiocellular carcinoma. (25551848)
2014
42
Impact of climate change and man-made irrigation systems on the transmission risk, long-term trend and seasonality of human and animal fascioliasis in Pakistan. (24893010)
2014
43
Seroprevalence of human fascioliasis using indirect ELISA in isfahan district, central iran in 2013. (25759726)
2014
44
Fascioliasis: A worldwide parasitic disease of importance in travel medicine. (25287722)
2014
45
Cutaneous images of interest of fascioliasis from India. (25118759)
2014
46
Neurological and ocular fascioliasis in humans. (24480313)
2014
47
Molecular and Morphological Characterization of Fasciola spp. Isolated from Different Host Species in a Newly Emerging Focus of Human Fascioliasis in Iran. (25018891)
2014
48
Fascioliasis. (24903364)
2014
49
Fascioliasis: a rare cause of liver abscess. (24385589)
2014
50
Investigation of the roles of fascioliasis and food allergy in intrahepatic eosinophilic proliferative pylephlebitis in Japanese Black cattle. (23131780)
2013

Variations for Fascioliasis

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Expression for genes affiliated with Fascioliasis

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Search GEO for disease gene expression data for Fascioliasis.

Pathways for genes affiliated with Fascioliasis

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GO Terms for genes affiliated with Fascioliasis

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Cellular components related to Fascioliasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:00057649.2CTSL, IL1B, SLC17A5
2extracellular spaceGO:00056157.0ALB, CP, CTSL, GPT, IL10, IL1B

Biological processes related to Fascioliasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid catabolic processGO:005099510.0IL1B, INS
2positive regulation of mitotic nuclear divisionGO:004584010.0IL1B, INS
3positive regulation of cytokine secretionGO:00507159.9IL10, INS
4agingGO:00075689.6CP, IL10, IL1B
5response to lipopolysaccharideGO:00324968.5IL10, IL1B, SELE

Sources for Fascioliasis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet