MCID: FSC002
MIFTS: 62

Fascioliasis malady

Rare diseases, Infectious diseases, Liver diseases categories
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Summaries for Fascioliasis

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CDC:3 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as "the common liver fluke" or "the sheep liver fluke." A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all 5 continents, in over 50 countries, especially where sheep or cattle are reared. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The immature larval flukes migrate through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes, which produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards based summary: Fascioliasis, also known as fasciola hepatica infection, is related to hepatitis and clonorchiasis. An important gene associated with Fascioliasis is SLC17A5 (solute carrier family 17 (acidic sugar transporter), member 5), and among its related pathways are LDL Oxidation in Atherogenesis and Cellular roles of Anthrax toxin. The compounds gold sodium thiomalate and il-12 have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and testes, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by fasciola hepatica or fasciola gigantica. during the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Aliases & Classifications for Fascioliasis

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Fascioliasis, Aliases & Descriptions:

Name: Fascioliasis 8 42 10 44 62
Fasciola Hepatica Infection 8 62
Infection by Fasciola 8 62
 
Sheep Liver Fluke Infection 8
Liver Flukes Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Liver diseases


External Ids:

Disease Ontology8 DOID:885
ICD9CM27 121.3
MeSH34 D005211
ICD1025 B66.3

Related Diseases for Fascioliasis

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Diseases related to Fascioliasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.6GUSB, GGT1, SLC17A5
2clonorchiasis31.2EPGN
3opisthorchiasis31.0GGT1, EPGN
4obstructive jaundice30.7ALPP, GGT1
5schistosomiasis30.4GUSB, IL10, IFNG, SRCIN1, FABP12, EPGN
6eosinophilia30.4IL10, IFNG, RNASE3
7leishmaniasis30.2IFNG, IL10
8cholestasis30.2GOT2, CP, ALPP, GGT1, SLC17A5
9visceral leishmaniasis30.2IFNG, IL10
10hepatitis c30.2GOT2, IFNG, IL10, GGT1, SLC17A5
11hepatitis b30.0GOT2, IFNG, ALPP, GGT1, SLC17A5
12pancreatitis29.7GOT2, INS, IL10, IL1B, ALPP, GGT1
13scrub typhus10.5SLC17A5
14neonatal hemochromatosis10.5GGT1, SLC17A5
15gallbladder disease10.5GOT2, GGT1
16extrahepatic cholestasis10.5GGT1, ALPP
17hepatitis a10.5GOT2
18degenerative disc disease10.5IL1B
19leukostasis10.5SELE
20rheumatoid vasculitis10.5SELE
21meningitis10.4IL1B
22pustulosis palmaris et plantaris10.4SELE
23intrahepatic cholestasis10.4ALPP, GGT1, SLC17A5
24pulmonary eosinophilia10.4RNASE3, GGT1
25cholelithiasis10.4GUSB, ALPP, GGT1
26acute liver failure10.4CP, SLC17A5
27von hippel-lindau disease10.4
28elephantiasis10.4RNASE3, SRCIN1
29skin disease10.4ALPP, IL1B
30bilirubin metabolic disorder10.3GGT1, SLC17A5
31galactosemia10.3CP, GGT1, SLC17A5
32onchocerciasis10.3RNASE3, SRCIN1
33calcinosis10.3ALPP
34portal hypertension10.3GGT1, SLC17A5
35pleurisy10.3IL1B
36choledocholithiasis10.3GUSB, ALPP, GGT1, SLC17A5
3721-hydroxylase deficiency10.3GUSB, ALPP, GGT1, SLC17A5
38cholangitis10.3GOT2, ALPP, GGT1, SLC17A5
39peritonitis10.3
40primary biliary cirrhosis10.3CP, ALPP, GGT1, SLC17A5
41leukopenia10.3SLC17A5, ALPP, GUSB, GOT2
42thrombocytopenia10.3GOT2, GUSB, ALPP, SLC17A5
43periodontal disease10.3GUSB, TNF, ALPP
44liver cirrhosis10.3CP, ALPP, GGT1, SLC17A5
45autosomal dominant hyper ige syndrome10.3RNASE3, IFNG
46paragonimiasis10.3
47gingivitis10.3ALPP, IL1B, GUSB
48blau syndrome10.2IL1B, TNF
49bacterial meningitis10.2GUSB, IL1B
50alcoholic hepatitis10.2TNF, IL10

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to fascioliasis

Symptoms for Fascioliasis

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Drugs & Therapeutics for Fascioliasis

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Drug clinical trials:

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Genetic Tests for Fascioliasis

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Anatomical Context for Fascioliasis

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MalaCards organs/tissues related to Fascioliasis:

32
Liver, Lung, Testes, Brain, T cells, Eye, Spleen, Colon, Kidney, Pancreas, Skin, Endothelial

Animal Models for Fascioliasis or affiliated genes

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MGI Mouse Phenotypes related to Fascioliasis:

36 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.1INS, TNF, SELE, CP, IFNG, IL10
2MP:00053798.8GGT1, IL10, IFNG, TNF, GUSB, INS
3MP:00053908.8INS, GUSB, TNF, IFNG, IL10, IL1B
4MP:00107718.8INS, GUSB, TNF, SELE, IFNG, IL10
5MP:00053898.6INS, GUSB, TNF, IFNG, IL10, ALPP
6MP:00053848.4INS, GUSB, TNF, SELE, CP, IFNG
7MP:00028738.4INS, GUSB, SELE, SORD, IFNG, IL10
8MP:00053858.4INS, TNF, SELE, CP, IFNG, IL10
9MP:00053978.4INS, GUSB, TNF, SELE, CP, IFNG
10MP:00053878.3INS, TNF, SELE, CP, IFNG, IL10
11MP:00053918.1SLC17A5, INS, TNF, SELE, CP, SORD
12MP:00053867.9INS, GUSB, TNF, SELE, CP, ME1
13MP:00053787.5SELE, TNF, GUSB, INS, ME1, IFNG
14MP:00107687.3INS, GUSB, TNF, SELE, ME1, IFNG
15MP:00053766.8CP, SELE, TNF, GUSB, INS, SORD

Publications for Fascioliasis

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Articles related to Fascioliasis:

(show top 50)    (show all 499)
idTitleAuthorsYear
1
Fascioliasis diagnosed by EUS and ERCP. (23987576)
2013
2
Application of a geographical information system approach for risk analysis of fascioliasis in southern EspiI8rito Santo state, Brazil. (23032288)
2012
3
Sporadic incidence of Fascioliasis detected during hepatobiliary procedures: a study of 18 patients from Sulaimaniyah governorate. (23259859)
2012
4
Evaluation of a 14.5 kDa-Fasciola gigantica fatty acid binding protein as a diagnostic antigen for human fascioliasis. (22113304)
2012
5
Lymnaea schirazensis, an overlooked snail distorting fascioliasis data: genotype, phenotype, ecology, worldwide spread, susceptibility, applicability. (21980347)
2011
6
Hyperendemic human fascioliasis in Andean valleys: an altitudinal transect analysis in children of Cajamarca province, Peru. (21767521)
2011
7
Hepatobiliary fascioliasis: a case with unusual radiological features. (19813166)
2010
8
Ineffectiveness of myrrh-derivative Mirazid against schistosomiasis and fascioliasis in humans. (21218718)
2010
9
Bridging gaps in the molecular phylogeny of the Lymnaeidae (Gastropoda: Pulmonata), vectors of Fascioliasis. (21143890)
2010
10
Chapter 2. Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control. (19622408)
2009
11
Treatment of human fascioliasis with triclabendazole: good news. (18346770)
2008
12
Screening for Indian isolates of egg-parasitic fungi for use in biological control of fascioliasis and amphistomiasis in ruminant livestock. (18462555)
2008
13
Effect of Fascioliasis on the pharmacokinetic parameters of triclabendazole in human subjects. (17265093)
2007
14
Evaluation of immunoglobulin G4 subclass antibody in a peptide-based enzyme-linked immunosorbent assay for the serodiagnosis of human fascioliasis. (17714604)
2007
15
Immune suppression in advanced chronic fascioliasis: an experimental study in a rat model. (17436231)
2007
16
Unusual thrombotic manifestations secondary to antiphospholipid syndrome and hepatic fascioliasis. (15908004)
2006
17
Geographical Information Systems risk assessment models for zoonotic fascioliasis in the South American Andes region. (16044684)
2005
18
Study of some immune aspects in patients with fascioliasis before and after Chommiphora molmol (Mirazid) treatment. (15125536)
2004
19
Clinical signs and household characteristics associated with human fascioliasis among rural population in Egypt: a case-control study. (15270537)
2003
20
Experimental fascioliasis in the rat-like hamster, Tscherskia triton, and other rodent hosts. (12798926)
2003
21
Molecular phylogenetic relationships in the aquatic snail genus Lymnaea, the intermediate host of the causative agent of fascioliasis: insights from broader taxon sampling. (12107463)
2002
22
Hepatic fascioliasis in the Americas: A new challenge for therapeutic endoscopy. (12145622)
2002
23
Soluble adhesion molecules as a marker of disease severity in human fascioliasis. (10946501)
2000
24
Hepatic fibrosis due to fascioliasis and/or schistosomiasis in Abis 1 village, Egypt. (12197343)
2000
25
Specific IgG avidity in acute and chronic human fascioliasis. (12197349)
2000
26
IgM and IgG cystatin capture enzyme linked immunosorbent assays: a tool for serodiagnosis and assessment of cure of acute fascioliasis after triclabendazole (TCZ; Fasinex) therapy. (11198366)
2000
27
New opportunities for the control of fascioliasis. (10327707)
1999
28
Circulating antibodies and antigens correlate with egg counts in human fascioliasis. (10583903)
1999
29
High endemicity of human fascioliasis between Lake Titicaca and La Paz valley, Bolivia. (10450437)
1999
30
Short report: Immunodiagnosis of human fascioliasis using recombinant Fasciola hepatica cathepsin L1 cysteine proteinase. (10344647)
1999
31
Evaluation of IHA test for fascioliasis in cases of hepatitis C virus infection. (8754655)
1996
32
Human fascioliasis in an Egyptian village: prevalence and some epidemiological determinants. (17214174)
1995
33
Intraocular fascioliasis: a case report. (8147493)
1994
34
Aberrant fascioliasis: ectopic focus in peritoneal cavity. (7844436)
1994
35
Radiological findings of human fascioliasis. (8508088)
1993
36
Use of LANDSAT MSS imagery and soil type in a geographic information system to assess site-specific risk of fascioliasis on Red River Basin farms in Louisiana. (1626889)
1992
37
Fascioliasis. (1419568)
1992
38
Decrease in albendazole sulphonation during experimental fascioliasis in sheep. (1776267)
1991
39
Successful treatment of acute fascioliasis with bithionol. (1959855)
1991
40
Molluscicidal trials and correlation between the presence of Tetrapleura tetraptera in an area and the absence of the intermediate hosts of schistosomiasis and fascioliasis in southwest Nigeria. (2255208)
1990
41
Sensitivity of crude and purified Fasciola antigens in immunological diagnosis of human fascioliasis. (2768848)
1989
42
Fascioliasis and hepatic affection. (3131442)
1988
43
A short note on praziquantel in human fascioliasis. (3773022)
1986
44
Incidence of experimental fascioliasis on hepatic disposition of [3H]tetracycline and [14C]rafoxanide in rats. (4067840)
1985
45
Impairment of drug metabolism by the liver in experimental fascioliasis in the rat. (6139454)
1983
46
Use of a partially purified Fasciola gigantica worm antigen in the serological diagnosis of human fascioliasis in Egypt. (6305221)
1983
47
Fascioliasis in beef cattle in north-west Argentina. (7123667)
1982
48
Ecological basis of parasite control: trematodes with special reference to fascioliasis. (6891528)
1982
49
A three-year study of Lymnaea truncatula habitats, disease foci of fascioliasis. (7284746)
1981
50
Human fascioliasis in Israel. An imported case. (7263203)
1981

Variations for Fascioliasis

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Expression for genes affiliated with Fascioliasis

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Expression patterns in normal tissues for genes affiliated with Fascioliasis

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Pathways for genes affiliated with Fascioliasis

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Pathways related to Fascioliasis according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL1B, TNF
29.9IL1B, TNF
39.7INS, SELE, IFNG
49.7TNF, SELE, IL1B
59.7IL1B, IL10, TNF
69.7TNF, IL10, IL1B
79.7IL1B, IL10, TNF
89.7IL1B, IFNG, INS
9
Show member pathways
9.7IL10, IFNG, TNF
10
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.7TNF, IFNG, IL1B
11
Show member pathways
9.7TNF, IFNG, IL1B
129.7IL1B, IFNG, TNF
13
Show member pathways
Immune response MIF in innate immunity response60
9.7IL1B, IFNG, TNF
149.7IL1B, IFNG, TNF
159.7IL1B, IFNG, TNF
169.7IL1B, IFNG, TNF
179.7TNF, IFNG, IL1B
18
Show member pathways
9.4TNF, IFNG, IL10, IL1B
19
Show member pathways
IL27-mediated signaling events37
9.4TNF, IFNG, IL10, IL1B
20
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4TNF, IFNG, IL10, IL1B
219.4IL1B, IL10, IFNG, TNF
229.4IL1B, IL10, IFNG, TNF
23
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.4IL1B, IL10, IFNG, TNF
249.4TNF, IFNG, IL10, IL1B
259.4TNF, IFNG, IL10, IL1B
26
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.4IL1B, IL10, IFNG, TNF
279.2IL1B, IL10, IFNG, SELE, TNF
289.2TNF, SELE, IFNG, IL10, IL1B
29
Show member pathways
9.1IL1B, IL10, IFNG, TNF, INS
30
Show member pathways
9.1INS, TNF, IFNG, IL10, IL1B
31
Show member pathways
thioredoxin pathway37
9.0INS, TNF, IFNG, IL1B, GGT1
32
Show member pathways
8.9INS, TNF, RNASE3, IFNG, IL10, IL1B
33
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
8.7GOT2, ME2, ME1
34
Show member pathways
7.3GOT2, INS, GUSB, SORD, ME1, ALPP

Compounds for genes affiliated with Fascioliasis

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Compounds related to Fascioliasis according to GeneCards/GeneDecks:

(show top 50)    (show all 211)
idCompoundScoreTop Affiliating Genes
1gold sodium thiomalate449.8IFNG, SELE, TNF, IL1B
2il-12449.8IL1B, IFNG, TNF, IL10
3nash449.7TNF, INS, GGT1, SLC17A5
4groalpha449.7SELE, IL10, TNF, IL1B
5okt3449.7IL10, IFNG, SELE, TNF
6budesonide44 50 1111.7RNASE3, TNF, IFNG, IL1B
7interferon gamma449.7IL10, IFNG, TNF
8fluticasone propionate44 50 61 1112.7IFNG, RNASE3, TNF, SELE, IL1B
9gm-csf44 2810.7TNF, IFNG, IL10, IL1B
10lipoteichoic acid449.7SELE, IL10, IL1B, TNF
11polymyxin b449.6IFNG, IL1B, TNF, IL10, SELE
12polyinosinic-polycytidylic acid449.6IL1B, IFNG, IL10, SELE, TNF
13neopterin449.6SLC17A5, TNF, IFNG, IL10, IL1B
14infliximab44 50 1111.6IL1B, IL10, IFNG, SELE, TNF
15vitamin b12449.6CP, ALPP, GGT1, SLC17A5, GUSB
16pdtc449.6TNF, IL1B, SELE, CP, IFNG
17phenobarbital44 28 50 1112.5ALPP, CP, GUSB, SLC17A5, GGT1
188-isoprostane449.5IL10, SELE, TNF, INS
19mycophenolate mofetil44 50 1111.5TNF, SELE, IFNG, GGT1, IL10
20carbamazepine44 50 1111.5ALPP, TNF, CP, GGT1, SLC17A5
21pentoxifylline44 1110.5IFNG, IL10, TNF, GGT1, IL1B
22atorvastatin44 50 28 24 1113.4TNF, SELE, IL10, ALPP, SLC17A5
23bezafibrate44 28 1111.4SLC17A5, GGT1, INS, ALPP
24prednisolone44 28 1111.4RNASE3, SLC17A5, ALPP, TNF, IL10, IFNG
25troglitazone44 28 61 1112.4TNF, SELE, IL1B, SLC17A5, INS
26rolipram44 61 2811.3TNF, SELE, IFNG, IL10
27simvastatin44 50 61 28 24 1114.3SLC17A5, TNF, SELE, ALPP, IFNG, IL10
28rantes449.3TNF, IL1B, IL10, IFNG, RNASE3, SELE
29quercetin44 61 24 1112.3IL10, GUSB, GGT1, SELE, IL1B, ALPP
30thyroxine44 2410.3IL10, ALPP, GGT1, SLC17A5, CP, INS
31methotrexate50 44 1111.3GGT1, SELE, IL10, TNF, IL1B, SLC17A5
32uric acid44 2410.3CP, INS, GGT1, SLC17A5, RNASE3, FABP12
33n acetylcysteine449.3IL1B, SELE, TNF, RNASE3, SLC17A5, GGT1
34hydrocortisone44 2 61 1112.2ALPP, IFNG, INS, TNF, IL10, IL1B
35endotoxin449.2TNF, SELE, IFNG, IL10, IL1B, SLC17A5
36fibrinogen449.2RNASE3, SLC17A5, CP, INS, TNF, SELE
37tacrolimus44 50 1111.2GGT1, SLC17A5, IFNG, TNF, INS, IL10
38histamine44 28 2411.2RNASE3, IL10, IL1B, SELE, GUSB, IFNG
39sb 20358044 6110.2TNF, ALPP, IL1B, IL10, IFNG, SELE
40etanercept44 50 1111.1IFNG, IL1B, IL10, TNF
41heparin44 28 24 1112.1CP, RNASE3, GGT1, SELE, ALPP, GUSB
42pge2448.9IFNG, ALPP, IL1B, GUSB, TNF, RNASE3
43vegf448.8IL10, RNASE3, IFNG, SELE, ALPP, CP
44superoxide44 249.6SLC17A5, IL1B, FABP12, GUSB, TNF, CP
45aspartate448.5GUSB, SLC17A5, SELE, CP, SORD, IL10
46testosterone44 61 24 1111.3SLC17A5, INS, SELE, CP, SORD, ALPP
47alanine448.2GGT1, INS, SELE, SLC17A5, CP, SORD
48dexamethasone44 50 28 1111.1IL1B, IL10, IFNG, INS, TNF, FABP12
49creatinine447.9SLC17A5, GGT1, ALPP, INS, GUSB, FABP12
50lactate447.6FABP12, GUSB, ALPP, TNF, SELE, SORD

GO Terms for genes affiliated with Fascioliasis

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Cellular components related to Fascioliasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6TNF, CP, RNASE3, EPGN, IFNG, IL1B
2extracellular spaceGO:0056157.8IL1B, INS, TNF, SELE, CP, SORD

Biological processes related to Fascioliasis according to GeneCards/GeneDecks:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:03280010.3TNF, IL10
2sequestering of triglycerideGO:03073010.3TNF, IL1B
3positive regulation of vitamin D biosynthetic processGO:06055710.3IFNG, TNF
4positive regulation of MHC class II biosynthetic processGO:04534810.3IFNG, IL10
5positive regulation of interleukin-6 biosynthetic processGO:04541010.3IFNG, IL1B
6positive regulation of heterotypic cell-cell adhesionGO:03411610.3TNF, IL1B
7negative regulation of cytokine secretion involved in immune responseGO:00274010.3TNF, IL10
8positive regulation of fever generationGO:03162210.3TNF, IL1B
9regulation of I-kappaB kinase/NF-kappaB signalingGO:04312210.2IL1B, TNF
10leukocyte tethering or rollingGO:05090110.1TNF, SELE
11positive regulation of calcidiol 1-monooxygenase activityGO:06055910.1IL1B, IFNG, TNF
12positive regulation of chemokine biosynthetic processGO:04508010.0IL1B, IFNG, TNF
13negative regulation of growth of symbiont in hostGO:04413010.0TNF, IFNG, IL10
14positive regulation of membrane protein ectodomain proteolysisGO:05104410.0TNF, IFNG, IL1B
15negative regulation of lipid catabolic processGO:05099510.0IL1B, TNF, INS
16positive regulation of cytokine secretionGO:05071510.0INS, TNF, IL10
17MAPK cascadeGO:00016510.0IL1B, TNF, INS
18negative regulation of interleukin-6 productionGO:0327159.9IL10, TNF
19positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.9TNF, IL10, IL1B
20defense response to bacteriumGO:0427429.9RNASE3, IFNG, IL10
21negative regulation of protein secretionGO:0507099.8INS, SRCIN1
22positive regulation of osteoclast differentiationGO:0456729.8TNF, IFNG
23positive regulation of nitric oxide biosynthetic processGO:0454299.8INS, TNF, IFNG, IL1B
24activation of MAPK activityGO:0001879.8TNF, EPGN, IL1B
25glutamate metabolic processGO:0065369.8GGT1, GOT2
26regulation of insulin secretionGO:0507969.7IL1B, IFNG, TNF, INS
27inflammatory responseGO:0069549.7TNF, SELE, IL10, IL1B
28positive regulation of NF-kappaB transcription factor activityGO:0510929.7IL1B, TNF, INS
29response to carbohydrateGO:0097439.7IL1B, ME1
30positive regulation of mitosisGO:0458409.7IL1B, EPGN, TNF, INS
31cellular amino acid biosynthetic processGO:0086529.7TNF, GOT2
32positive regulation of NF-kappaB import into nucleusGO:0423469.6TNF, IL1B
33malate metabolic processGO:0061089.5ME2, ME1
34glucose metabolic processGO:0060069.1GOT2, INS, TNF, SORD

Molecular functions related to Fascioliasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.3TNF, IFNG, IL10, IL1B
2oxaloacetate decarboxylase activityGO:0089489.2ME1, ME2
3malate dehydrogenase (decarboxylating) (NAD+) activityGO:0044718.9ME1, ME2
4NAD bindingGO:0512878.6ME1, ME2, SORD

Products for genes affiliated with Fascioliasis

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