MCID: FSC002
MIFTS: 39

Fascioliasis malady

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Fascioliasis

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Aliases & Descriptions for Fascioliasis:

Name: Fascioliasis 10 45 47 12 36 2 65
Fasciola Hepatica Infection 10 65
Sheep Liver Fluke Infection 10
 
Infection by Fasciola 10
Liver Flukes Nos 10

Classifications:



External Ids:

Disease Ontology10 DOID:885
ICD1027 B66.3
ICD9CM29 121.3
MeSH36 D005211
UMLS65 C0015652, C1331532

Summaries for Fascioliasis

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CDC:2 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as "the common liver fluke" or "the sheep liver fluke." A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all 5 continents, in over 50 countries, especially where sheep or cattle are reared. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The immature larval flukes migrate through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes, which produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards based summary: Fascioliasis, also known as fasciola hepatica infection, is related to food allergy and hepatitis. An important gene associated with Fascioliasis is ALPP (Alkaline Phosphatase, Placental), and among its related pathways are African trypanosomiasis and Malaria. Affiliated tissues include liver, lung and thyroid.

Disease Ontology:10 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Related Diseases for Fascioliasis

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Diseases related to Fascioliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1food allergy29.8IL1B, SELE
2hepatitis10.5
3kartagener syndrome10.5ALPP, IL1B
4pleomorphic adenoma carcinoma10.4ALPP, IL1B
5graphite pneumoconiosis10.4CP, INS
6schistosomiasis10.4
7benign focal amyotrophy10.4ALPP, IL1B
8casp10-related autoimmune lymphoproliferative syndrome10.4INS, SELE
9duodenum cancer10.3IL1B, SELE
10gestational diabetes10.2INS, SELE
11atypical teratoid rhabdoid tumor10.2ALPP, CTSL
12granulomatous amebic encephalitis10.2CTSL, IL1B
13mixed mineral dust pneumoconiosis10.2CP, IL1B
14bone cancer10.2IL1B, INS
15diphyllobothriasis10.2MT-CO1, SELE
16rectum signet ring adenocarcinoma10.1ALPP, IL1B
17mobitz type ii atrioventricular block10.1IL1B, MT-CO1
18mitochondrial metabolism disease10.1ALPP, IL1B, SELE
19matsoukas liarikos giannika syndrome10.1INS, MT-CO1
20long bone adamantinoma10.1IL1B, SELE
21peritonitis10.0
22giardiasis10.0CTSF, MT-CO1
23paragonimiasis10.0
24pancreatitis10.0
25hepatitis c virus9.9
26dicrocoeliasis9.9
27clonorchiasis9.9
28opisthorchiasis9.9
29hepatitis c9.9
30eosinophilia9.9
31hyperglycemia9.9IL1B, INS
32cholangiocarcinoma9.8
33cysticercosis9.8
34malignant giant cell tumor of the tendon sheath9.8IL1B, SELE
35spinal meningioma9.8ALPP, CTSL, MT-CO1
36melioidosis9.7
37osteoporosis9.7
38deficiency anemia9.7
39hemolytic anemia9.7
40hepatitis b9.7
41intestinal schistosomiasis9.7
42dirofilariasis9.7
43iron deficiency anemia9.7
44cholestasis9.7
45obstructive jaundice9.7
46acute cholangitis9.7
47echinococcosis9.7
48ovarian cancer9.7
49acute pancreatitis9.7
50antiphospholipid syndrome9.7

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to fascioliasis

Symptoms for Fascioliasis

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Drugs & Therapeutics for Fascioliasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Fascioliasis


Cochrane evidence based reviews: fascioliasis

Genetic Tests for Fascioliasis

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Anatomical Context for Fascioliasis

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MalaCards organs/tissues related to Fascioliasis:

33
Liver, Lung, Thyroid, Kidney, Prostate, Breast, T cells

Animal Models for Fascioliasis or affiliated genes

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Publications for Fascioliasis

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Articles related to Fascioliasis:

(show top 50)    (show all 534)
idTitleAuthorsYear
1
Diagnosis of human fascioliasis in Arusha region, northern Tanzania by microscopy and clinical manifestations in patients. (26695775)
2015
2
Fascioliasis: An Ongoing Zoonotic Trematode Infection. (26417603)
2015
3
Epidemiology of Human Fascioliasis and Intestinal Helminthes in Rural Areas of Boyer-Ahmad Township, Southwest Iran; A Population Based Study. (26744710)
2015
4
Fascioliasis diagnosed by EUS and ERCP. (23987576)
2013
5
Application of a geographical information system approach for risk analysis of fascioliasis in southern EspiI8rito Santo state, Brazil. (23032288)
2012
6
Sporadic incidence of Fascioliasis detected during hepatobiliary procedures: a study of 18 patients from Sulaimaniyah governorate. (23259859)
2012
7
Evaluation of a 14.5 kDa-Fasciola gigantica fatty acid binding protein as a diagnostic antigen for human fascioliasis. (22113304)
2012
8
Lymnaea schirazensis, an overlooked snail distorting fascioliasis data: genotype, phenotype, ecology, worldwide spread, susceptibility, applicability. (21980347)
2011
9
Hyperendemic human fascioliasis in Andean valleys: an altitudinal transect analysis in children of Cajamarca province, Peru. (21767521)
2011
10
Hepatobiliary fascioliasis: a case with unusual radiological features. (19813166)
2010
11
Ineffectiveness of myrrh-derivative Mirazid against schistosomiasis and fascioliasis in humans. (21218718)
2010
12
Chapter 2. Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control. (19622408)
2009
13
Treatment of human fascioliasis with triclabendazole: good news. (18346770)
2008
14
Screening for Indian isolates of egg-parasitic fungi for use in biological control of fascioliasis and amphistomiasis in ruminant livestock. (18462555)
2008
15
Effect of Fascioliasis on the pharmacokinetic parameters of triclabendazole in human subjects. (17265093)
2007
16
Evaluation of immunoglobulin G4 subclass antibody in a peptide-based enzyme-linked immunosorbent assay for the serodiagnosis of human fascioliasis. (17714604)
2007
17
Immune suppression in advanced chronic fascioliasis: an experimental study in a rat model. (17436231)
2007
18
Unusual thrombotic manifestations secondary to antiphospholipid syndrome and hepatic fascioliasis. (15908004)
2006
19
Eight cases of fascioliasis: clinical and microbiological features. (16309872)
2006
20
Geographical Information Systems risk assessment models for zoonotic fascioliasis in the South American Andes region. (16044684)
2005
21
Clinical signs and household characteristics associated with human fascioliasis among rural population in Egypt: a case-control study. (15270537)
2003
22
Molecular phylogenetic relationships in the aquatic snail genus Lymnaea, the intermediate host of the causative agent of fascioliasis: insights from broader taxon sampling. (12107463)
2002
23
Hepatic fascioliasis in the Americas: A new challenge for therapeutic endoscopy. (12145622)
2002
24
Soluble adhesion molecules as a marker of disease severity in human fascioliasis. (10946501)
2000
25
Hepatic fibrosis due to fascioliasis and/or schistosomiasis in Abis 1 village, Egypt. (12197343)
2000
26
Specific IgG avidity in acute and chronic human fascioliasis. (12197349)
2000
27
IgM and IgG cystatin capture enzyme linked immunosorbent assays: a tool for serodiagnosis and assessment of cure of acute fascioliasis after triclabendazole (TCZ; Fasinex) therapy. (11198366)
2000
28
New opportunities for the control of fascioliasis. (10327707)
1999
29
Circulating antibodies and antigens correlate with egg counts in human fascioliasis. (10583903)
1999
30
High endemicity of human fascioliasis between Lake Titicaca and La Paz valley, Bolivia. (10450437)
1999
31
Short report: Immunodiagnosis of human fascioliasis using recombinant Fasciola hepatica cathepsin L1 cysteine proteinase. (10344647)
1999
32
Evaluation of IHA test for fascioliasis in cases of hepatitis C virus infection. (8754655)
1996
33
Human fascioliasis in an Egyptian village: prevalence and some epidemiological determinants. (17214174)
1995
34
Intraocular fascioliasis: a case report. (8147493)
1994
35
Aberrant fascioliasis: ectopic focus in peritoneal cavity. (7844436)
1994
36
Radiological findings of human fascioliasis. (8508088)
1993
37
Use of LANDSAT MSS imagery and soil type in a geographic information system to assess site-specific risk of fascioliasis on Red River Basin farms in Louisiana. (1626889)
1992
38
Fascioliasis. (1419568)
1992
39
Decrease in albendazole sulphonation during experimental fascioliasis in sheep. (1776267)
1991
40
Molluscicidal trials and correlation between the presence of Tetrapleura tetraptera in an area and the absence of the intermediate hosts of schistosomiasis and fascioliasis in southwest Nigeria. (2255208)
1990
41
Sensitivity of crude and purified Fasciola antigens in immunological diagnosis of human fascioliasis. (2768848)
1989
42
Fascioliasis and hepatic affection. (3131442)
1988
43
A short note on praziquantel in human fascioliasis. (3773022)
1986
44
Incidence of experimental fascioliasis on hepatic disposition of [3H]tetracycline and [14C]rafoxanide in rats. (4067840)
1985
45
Impairment of drug metabolism by the liver in experimental fascioliasis in the rat. (6139454)
1983
46
Use of a partially purified Fasciola gigantica worm antigen in the serological diagnosis of human fascioliasis in Egypt. (6305221)
1983
47
Fascioliasis in beef cattle in north-west Argentina. (7123667)
1982
48
Ecological basis of parasite control: trematodes with special reference to fascioliasis. (6891528)
1982
49
A three-year study of Lymnaea truncatula habitats, disease foci of fascioliasis. (7284746)
1981
50
Human fascioliasis in Israel. An imported case. (7263203)
1981

Variations for Fascioliasis

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Expression for genes affiliated with Fascioliasis

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Search GEO for disease gene expression data for Fascioliasis.

Pathways for genes affiliated with Fascioliasis

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Pathways related to Fascioliasis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7IL1B, SELE
29.7IL1B, SELE
39.6INS, SELE

GO Terms for genes affiliated with Fascioliasis

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Biological processes related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of nitric oxide biosynthetic processGO:004542910.0IL1B, INS
2negative regulation of lipid catabolic processGO:005099510.0IL1B, INS
3positive regulation of mitotic nuclear divisionGO:00458409.9IL1B, INS
4wound healingGO:00420609.8IL1B, INS
5regulation of insulin secretionGO:00507969.6IL1B, INS
6response to copper ionGO:00466889.5CP, MT-CO1
7agingGO:00075688.8CP, IL1B, MT-CO1

Sources for Fascioliasis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet