MCID: FSC002
MIFTS: 45

Fascioliasis

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Fascioliasis

MalaCards integrated aliases for Fascioliasis:

Name: Fascioliasis 12 72 49 51 3 41 14 69
Fasciola Hepatica Infection 12 69
Sheep Liver Fluke Infection 12
Infection by Fasciola 12
Liver Flukes Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:885
ICD10 32 B66.3
ICD9CM 34 121.3
MeSH 41 D005211
SNOMED-CT 64 111922007 187125007

Summaries for Fascioliasis

CDC : 3 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as "the common liver fluke" or "the sheep liver fluke." A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all 5 continents, in over 50 countries, especially where sheep or cattle are reared. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The immature larval flukes migrate through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes, which produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards based summary : Fascioliasis, also known as fasciola hepatica infection, is related to opisthorchiasis and schistosomiasis. An important gene associated with Fascioliasis is SLC17A5 (Solute Carrier Family 17 Member 5), and among its related pathways/superpathways are Allograft rejection and Toxoplasmosis. Affiliated tissues include liver, lung and testes, and related phenotypes are liver/biliary system and vision/eye

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Wikipedia : 72 Fasciolosis is a parasitic worm infection caused by the common liver fluke Fasciola hepatica as well as... more...

Related Diseases for Fascioliasis

Diseases related to Fascioliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
# Related Disease Score Top Affiliating Genes
1 opisthorchiasis 30.2 GPT IL1B
2 schistosomiasis 30.2 ALB IFNG IL10
3 immune suppression 29.7 IFNG IL10
4 obstructive jaundice 29.6 ALB ALPP GPT SLC17A5
5 clonorchiasis 29.3 CTSL IFNG IL10
6 hepatitis c 29.3 GPT IFNG IL10
7 food allergy 29.2 ALB IFNG IL10
8 peritonitis 29.1 ALB IFNG IL10 IL1B
9 hepatitis b 29.0 ALB GPT IFNG SLC17A5
10 leishmaniasis 28.9 IFNG IL10 IL1B
11 visceral leishmaniasis 28.6 ALB IFNG IL10 IL1B
12 osteoporosis 28.0 ALB ALPP IFNG IL1B INS
13 paraquat poisoning 10.5 GPT SLC17A5
14 pyridoxine deficiency 10.5 GPT SLC17A5
15 primary hepatic neuroendocrine carcinoma 10.5 ALPP GPT
16 hepatitis 10.5
17 meningitis and encephalitis 10.4 ALB CP
18 hepatic coma 10.4 ALB GPT
19 uremic pruritus 10.3 IL1B SLC17A5
20 schistosoma mansoni infection, susceptibility/ 10.3
21 boutonneuse fever 10.3 CP SELE
22 endodermal sinus tumor 10.3 ALB ALPP
23 kwashiorkor 10.3 ALB GPT SLC17A5
24 analbuminemia 10.3 ALB GPT SLC17A5
25 acute liver failure 10.3 ALB GPT SLC17A5
26 euthyroid sick syndrome 10.3 ALB IL1B
27 hepatic tuberculosis 10.3 ALB ALPP GPT
28 hepatic encephalopathy 10.3 ALB GPT SLC17A5
29 hypersensitivity reaction type iii disease 10.3 ALB SELE
30 viral hepatitis 10.3 ALB GPT SLC17A5
31 compartment syndrome 10.3 ALB SLC17A5
32 liver cirrhosis 10.2 ALB GPT SLC17A5
33 protein-energy malnutrition 10.2 ALB CP GPT
34 wilson disease 10.2 ALB CP GPT
35 background diabetic retinopathy 10.2 ALB INS
36 taeniasis 10.2 CTSL IL10
37 retinitis pigmentosa 60 10.2 IL1B SELE
38 legionnaires' disease 10.2 ALB SLC17A5
39 actinic prurigo 10.2 IL1B SELE
40 fetal erythroblastosis 10.1 ALB INS
41 nonalcoholic steatohepatitis 10.1 GPT INS SLC17A5
42 autonomic nervous system disease 10.1 ALB INS
43 choledocholithiasis 10.1 ALB ALPP GPT SLC17A5
44 primary biliary cirrhosis 10.1 ALB ALPP GPT SLC17A5
45 kawasaki disease 10.1 ALB IL10 SELE
46 endometritis 10.0 IL1B SELE SLC17A5
47 histoplasmosis 10.0 IFNG SLC17A5
48 primary amebic meningoencephalitis 10.0 CTSL IL1B
49 hyperlucent lung 10.0 IFNG IL10
50 pyelonephritis 10.0 ALB IL10 IL1B

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to Fascioliasis

Symptoms & Phenotypes for Fascioliasis

MGI Mouse Phenotypes related to Fascioliasis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.43 ALB CP IFNG IL10 INS SELE
2 vision/eye MP:0005391 9.1 CP IFNG IL10 INS SELE SLC17A5

Drugs & Therapeutics for Fascioliasis

Search Clinical Trials , NIH Clinical Center for Fascioliasis

Cochrane evidence based reviews: fascioliasis

Genetic Tests for Fascioliasis

Anatomical Context for Fascioliasis

MalaCards organs/tissues related to Fascioliasis:

38
Liver, Lung, Testes, Brain, T Cells, Endothelial, Skin

Publications for Fascioliasis

Articles related to Fascioliasis:

(show top 50) (show all 560)
# Title Authors Year
1
Lethal Fascioliasis in Capybaras (Hydrochoerus hydrochaeris) in Brazil. ( 29185852 )
2018
2
First case report of retroperitoneal metastasis of fascioliasis after surgery. ( 29390366 )
2017
3
Fascioliasis: A report on a case presenting with abdominal pain. ( 28988787 )
2017
4
Hepatic fascioliasis presenting with bile duct obstruction: a case report. ( 29158867 )
2017
5
Seroprevalence and Risk Factors of Fascioliasis in Yaks, Bos grunniens, from Three Counties of Gansu Province, China. ( 28285513 )
2017
6
Fascioliasis: A Rare Parasitic Infection-Mimicking Tumor in the Liver: Report of Two Cases. ( 28272650 )
2017
7
High prevalence of cattle fascioliasis in coastal areas of Thua Thien Hue province, Vietnam. ( 28458272 )
2017
8
Hepatic fascioliasis in Mashhad, Northeast Iran: first report. ( 28954086 )
2017
9
A case of biliary fascioliasis mimicking a common bile duct tumor (with video). ( 28440243 )
2017
10
Fascioliasis-a rare cause of hepatic nodules. ( 28566417 )
2017
11
Production of Monoclonal Antibody Against Excretory-Secretory Antigen of Fasciola hepatica and Evaluation of Its Efficacy in the Diagnosis of Fascioliasis. ( 28186433 )
2017
12
Immunodiagnosis of Human Fascioliasis: An Update of Concepts and Performances of the Serological Assays. ( 28764235 )
2017
13
Fascioliasis risk factors and space-time clusters in domestic ruminants in Bangladesh. ( 28482863 )
2017
14
Expression, purification and in vitro refolding of the recombinant truncated Saposin-like protein 2 antigen for development of diagnosis of human fascioliasis. ( 28300559 )
2017
15
Epidemiology of bovine fascioliasis in the Nile Delta region of Egypt: Its prevalence, evaluation of risk factors, and its economic significance. ( 29184371 )
2017
16
Prevalence of fascioliasis (liver flukes) infection in cattle and buffaloes slaughtered at the municipal abattoir of El-Kharga, Egypt. ( 28919682 )
2017
17
DNA multigene characterization of Fasciola hepatica and Lymnaea neotropica and its fascioliasis transmission capacity in Uruguay, with historical correlation, human report review and infection risk analysis. ( 28158188 )
2017
18
Human fascioliasis by Fasciola hepatica: the first case report in Nepal. ( 28870243 )
2017
19
Human Cases of Fascioliasis in Fujian Province, China. ( 28285507 )
2017
20
Epidemiological analysis of human fascioliasis in northeastern Punjab, Pakistan. ( 26763724 )
2016
21
Evaluation of patients diagnosed with fascioliasis: A six-year experience at a university hospital in Turkey. ( 27131001 )
2016
22
Human fascioliasis endemic areas in Argentina: multigene characterisation of the lymnaeid vectors and climatic-environmental assessment of the transmission pattern. ( 27229862 )
2016
23
Evaluation of modified Dennis parasitological technique for diagnosis of bovine fascioliasis. ( 27622626 )
2016
24
Animal Fascioliasis: Perspectives from high altitudinal regions. ( 27890078 )
2016
25
Treatment Failure after Multiple Courses of Triclabendazole among Patients with Fascioliasis in Cusco, Peru: A Case Series. ( 26808543 )
2016
26
First Report of Human Fascioliasis in an Endemic Region of Bovine Fascioliasis in Caldas-Colombia. ( 27045315 )
2016
27
Development of Two FhSAP2 Recombinant-Based Assays for Immunodiagnosis of Human Chronic Fascioliasis. ( 27549636 )
2016
28
Seroprevalence of Human Fascioliasis in Chaharmahal and Bakhtiyari Province, Southwestern Iran. ( 27648421 )
2016
29
Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in blood samples diagnosed in Medic Medical Center Laboratory, Ho Chi Minh City, Vietnam in 2012. ( 27595647 )
2016
30
A pediatric case of Fascioliasis with eosinophilic pneumonia. ( 27922247 )
2016
31
Endoscopic Extraction of Biliary Fascioliasis Diagnosed Using Intraductal Ultrasonography in a Patient with Acute Cholangitis. ( 26668810 )
2015
32
Fascioliasis simulating an intrahepatic cholangiocarcinoma-Case report with imaging and pathology correlation. ( 25713810 )
2015
33
Pathology in practice. Distomiasis (fascioliasis) in a New Mexico Dahl sheep. ( 26043127 )
2015
34
Access to, and use of, water by populations living in a schistosomiasis and fascioliasis co-endemic area of northern CA'te d'Ivoire. ( 26004285 )
2015
35
Developing a climate-based risk map of fascioliasis outbreaks in Iran. ( 25982974 )
2015
36
Screening for Zoonotic Fascioliasis in Slaughtered Large Ruminants in Abattoirs in Perak, Malaysia. ( 26868715 )
2015
37
A Case of Fascioliasis Treated Successfully Without Sequelae in a Japanese Expatriate Living in Jakarta. ( 26309420 )
2015
38
Biochemical assessment of oxidative status versus liver enzymes in patients with chronic fascioliasis. ( 26688624 )
2015
39
Fascioliasis: An Ongoing Zoonotic Trematode Infection. ( 26417603 )
2015
40
Education and imaging. Hepatology: Fascioliasis: a rare cause of hepatic pseudoaneurysmal rupture. ( 25536460 )
2015
41
Diagnosis of human fascioliasis in Arusha region, northern Tanzania by microscopy and clinical manifestations in patients. ( 26695775 )
2015
42
The Status of Human and Animal Fascioliasis in Iran: A Narrative Review Article. ( 26622287 )
2015
43
Epidemiology of Human Fascioliasis and Intestinal Helminthes in Rural Areas of Boyer-Ahmad Township, Southwest Iran; A Population Based Study. ( 26744710 )
2015
44
The Endemicity of Human Fascioliasis in Guilan Province, Northern Iran: the Baseline for Implementation of Control Strategies. ( 26056669 )
2015
45
Biliary Fascioliasis Diagnosed on EUS. ( 26394385 )
2015
46
Fascioliasis in Australian travellers to Bali. ( 26268290 )
2015
47
Familial Trichostrongylus Infection Misdiagnosed as Acute Fascioliasis. ( 26402161 )
2015
48
Seroprevalence of human fascioliasis in Van province, Turkey. ( 26006203 )
2015
49
CLINICOPATHOLOGIC CORRELATES OF FASCIOLIASIS IN TWO EASTERN GREY KANGAROOS (MACROPUS GIGANTEUS). ( 26667560 )
2015
50
Performance of a 27 kDa Fasciola hepatica Antigen in the Diagnosis of Human Fascioliasis. ( 25949054 )
2015

Variations for Fascioliasis

Expression for Fascioliasis

Search GEO for disease gene expression data for Fascioliasis.

Pathways for Fascioliasis

Pathways related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.46 CTSL IFNG IL10 IL1B INS
2
Show member pathways
12.05 IFNG IL10 IL1B
3
Show member pathways
12.04 ALB IFNG IL1B INS
4 12.03 IFNG IL10 IL1B
5
Show member pathways
11.97 CTSL IFNG IL1B
6
Show member pathways
11.94 IFNG IL10 IL1B
7 11.87 ALB ALPP INS
8 11.74 IFNG IL1B INS
9
Show member pathways
11.72 IFNG IL10 IL1B
10 11.7 CTSL IFNG IL1B SELE
11 11.67 IFNG IL10 IL1B
12 11.63 CTSL IFNG IL1B
13 11.56 IFNG IL10 IL1B
14 11.5 IFNG IL10 IL1B
15
Show member pathways
11.41 IFNG IL1B SELE
16 11.28 IFNG INS SELE
17 11.12 IFNG IL1B
18 11.01 IFNG IL10
19 10.98 IFNG IL1B
20 10.95 IFNG IL10 IL1B SELE
21 10.81 IFNG IL10 IL1B
22 10.75 GPT INS
23 10.47 IFNG IL10 IL1B SELE

GO Terms for Fascioliasis

Cellular components related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 ALB CP CTSL IFNG IL10 IL1B
2 extracellular space GO:0005615 9.28 ALB CP CTSL GPT IFNG IL10

Biological processes related to Fascioliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.67 IFNG IL10 IL1B INS
2 response to lipopolysaccharide GO:0032496 9.63 IL10 IL1B SELE
3 positive regulation of cytokine secretion GO:0050715 9.43 IL10 INS
4 positive regulation of mitotic nuclear division GO:0045840 9.4 IL1B INS
5 negative regulation of lipid catabolic process GO:0050995 9.32 IL1B INS
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.26 IFNG IL1B
7 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.16 IL10 IL1B
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.13 IFNG IL1B INS
9 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.62 IFNG IL1B

Sources for Fascioliasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....