MCID: FSC002
MIFTS: 42

Fascioliasis malady

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Fascioliasis

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Aliases & Descriptions for Fascioliasis:

Name: Fascioliasis 11 48 50 2 39 13 68
Fasciola Hepatica Infection 11 68
Sheep Liver Fluke Infection 11
 
Infection by Fasciola 11
Liver Flukes Nos 11

Classifications:



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Disease Ontology11 DOID:885
ICD1030 B66.3
ICD9CM32 121.3
MeSH39 D005211

Summaries for Fascioliasis

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CDC:2 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as "the common liver fluke" or "the sheep liver fluke." A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all 5 continents, in over 50 countries, especially where sheep or cattle are reared. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The immature larval flukes migrate through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes, which produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards based summary: Fascioliasis, also known as fasciola hepatica infection, is related to hepatitis and gastric neuroendocrine tumor type 1. An important gene associated with Fascioliasis is SLC17A5 (Solute Carrier Family 17 Member 5), and among its related pathways are Cori Cycle and OX40 Pathway. Affiliated tissues include liver, lung and testes, and related mouse phenotypes are liver/biliary system and vision/eye.

Disease Ontology:11 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Related Diseases for Fascioliasis

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Diseases related to Fascioliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis10.3
2gastric neuroendocrine tumor type 110.3GPT, SLC17A5
3radiation induced cancer10.3GPT, SLC17A5
4jejunal neuroendocrine tumor10.3ALPP, GPT
5neurological manifestations of pompe disease10.2ALB, CP
6schistosomiasis10.2
7female infertility of uterine origin10.2ALB, GPT, SLC17A5
8retinal arterial macroaneurysm with supravalvular pulmonic stenosis10.2ALB, GPT, SLC17A5
9acute monocytic leukemia10.2ALB, GPT, SLC17A5
10bile duct cystadenocarcinoma10.2ALB, ALPP, GPT
11submucous uterine fibroid10.2ALB, INS
12congenital hypoplastic anemia10.2ALB, GPT, SLC17A5
13hypersensitivity syndrome, carbamazepine-induced10.2ALB, INS
14noninfectious dermatoses of eyelid10.2ALB, GPT, SLC17A5
15asymptomatic neurosyphilis10.2IFNG, IL10
16bladder sarcoma10.1ALB, CP, GPT
17not otherwise specified 3-mga-uria type10.1GPT, INS, SLC17A5
18auditory neuropathy, autosomal dominant, 110.1ALB, CP, GPT
19severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive10.1IFNG, IL10
20tungiasis10.1IFNG, IL10
21benign deep fibrous histiocytoma10.1ALB, GPT, IFNG
22israeli tick typhus10.1IFNG, SELE
23hemolytic-uremic syndrome10.1ALB, GPT, IFNG
24pulpitis10.1IFNG, IL10, SLC17A5
25lymphoblastic lymphoma10.1ALB, GPT, SLC17A5
26kohler's disease10.1ALB, ALPP, GPT, SLC17A5
27paranasal sinus sarcoma10.1ALB, ALPP, GPT, SLC17A5
28laryngotracheoesophageal cleft type 210.1IL1B, SLC17A5
29de quervain disease10.1CP, SELE
30ciliary discoordination, due to random ciliary orientation10.1ALB, IFNG, IL10
31stocco dos santos syndrome10.1IFNG, IL1B
32lipid metabolism disorder10.1IFNG, INS
33non-gestational choriocarcinoma10.1ALB, IFNG, IL10
34plummer's disease10.1ALB, IFNG, IL10
35hypotrichosis-lymphedema-telangiectasia-renal defect syndrome10.1IL1B, SELE
36depressed scar10.1ALB, IFNG, IL10
37mansonelliasis10.1ALB, IFNG, IL10
38paratyphoid fever10.0ALB, IFNG, IL10
39liver inflammatory pseudotumor10.0ALB, IFNG, IL10
40amelogenesis imperfecta10.0ALB, GPT, IL10, SLC17A5
41uterus interstitial leiomyoma10.0ALB, IFNG, IL10
42hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.0ALB, IL10, SELE
43glucosephosphate dehydrogenase deficiency10.0ALB, IL1B
44scleral disease10.0ALB, IFNG, IL10
45giant cell glioblastoma10.0IFNG, IL1B
46periarthritis10.0CP, IFNG, IL10
47chordoid meningioma10.0ALB, IL10, IL1B
48breast apocrine carcinoma in situ10.0ALB, IL10, IL1B
49denys-drash syndrome10.0IFNG, IL10, INS
50unilateral hypoactive labyrinth10.0ALB, IL10, IL1B

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to fascioliasis

Symptoms & Phenotypes for Fascioliasis

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MGI Mouse Phenotypes related to Fascioliasis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7ALB, CP, IFNG, IL10, INS, SELE
2MP:00053918.0CP, IFNG, IL10, INS, SELE, SLC17A5

Drugs & Therapeutics for Fascioliasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Fascioliasis


Cochrane evidence based reviews: fascioliasis

Genetic Tests for Fascioliasis

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Anatomical Context for Fascioliasis

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MalaCards organs/tissues related to Fascioliasis:

36
Liver, Lung, Testes, Brain, T cells, Endothelial, Skin

Publications for Fascioliasis

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Articles related to Fascioliasis:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
First Report of Human Fascioliasis in an Endemic Region of Bovine Fascioliasis in Caldas-Colombia. (27045315)
2016
2
Evaluation of modified Dennis parasitological technique for diagnosis of bovine fascioliasis. (27622626)
2016
3
Animal Fascioliasis: Perspectives from high altitudinal regions. (27890078)
2016
4
Human fascioliasis endemic areas in Argentina: multigene characterisation of the lymnaeid vectors and climatic-environmental assessment of the transmission pattern. (27229862)
2016
5
Treatment Failure after Multiple Courses of Triclabendazole among Patients with Fascioliasis in Cusco, Peru: A Case Series. (26808543)
2016
6
Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in blood samples diagnosed in Medic Medical Center Laboratory, Ho Chi Minh City, Vietnam in 2012. (27595647)
2016
7
A pediatric case of Fascioliasis with eosinophilic pneumonia. (27922247)
2016
8
Epidemiological analysis of human fascioliasis in northeastern Punjab, Pakistan. (26763724)
2016
9
Evaluation of patients diagnosed with fascioliasis: A six-year experience at a university hospital in Turkey. (27131001)
2016
10
Development of Two FhSAP2 Recombinant-Based Assays for Immunodiagnosis of Human Chronic Fascioliasis. (27549636)
2016
11
Seroprevalence of Human Fascioliasis in Chaharmahal and Bakhtiyari Province, Southwestern Iran. (27648421)
2016
12
Access to, and use of, water by populations living in a schistosomiasis and fascioliasis co-endemic area of northern CA'te d'Ivoire. (26004285)
2015
13
Familial Trichostrongylus Infection Misdiagnosed as Acute Fascioliasis. (26402161)
2015
14
CLINICOPATHOLOGIC CORRELATES OF FASCIOLIASIS IN TWO EASTERN GREY KANGAROOS (MACROPUS GIGANTEUS). (26667560)
2015
15
Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children. (26312936)
2015
16
Human Fascioliasis: A Re-emerging Disease in Upper Egypt. (25870421)
2015
17
The Status of Human and Animal Fascioliasis in Iran: A Narrative Review Article. (26622287)
2015
18
Endoscopic Extraction of Biliary Fascioliasis Diagnosed Using Intraductal Ultrasonography in a Patient with Acute Cholangitis. (26668810)
2015
19
Fascioliasis: An Ongoing Zoonotic Trematode Infection. (26417603)
2015
20
Pathology in practice. Distomiasis (fascioliasis) in a New Mexico Dahl sheep. (26043127)
2015
21
Screening for Zoonotic Fascioliasis in Slaughtered Large Ruminants in Abattoirs in Perak, Malaysia. (26868715)
2015
22
A Case of Fascioliasis Treated Successfully Without Sequelae in a Japanese Expatriate Living in Jakarta. (26309420)
2015
23
Epidemiology of Human Fascioliasis and Intestinal Helminthes in Rural Areas of Boyer-Ahmad Township, Southwest Iran; A Population Based Study. (26744710)
2015
24
Developing a climate-based risk map of fascioliasis outbreaks in Iran. (25982974)
2015
25
Diagnosis of human fascioliasis in Arusha region, northern Tanzania by microscopy and clinical manifestations in patients. (26695775)
2015
26
Biochemical assessment of oxidative status versus liver enzymes in patients with chronic fascioliasis. (26688624)
2015
27
Biliary Fascioliasis Diagnosed on EUS. (26394385)
2015
28
The Endemicity of Human Fascioliasis in Guilan Province, Northern Iran: the Baseline for Implementation of Control Strategies. (26056669)
2015
29
Fascioliasis in Australian travellers to Bali. (26268290)
2015
30
Seroprevalence of human fascioliasis in Van province, Turkey. (26006203)
2015
31
Education and imaging. Hepatology: Fascioliasis: a rare cause of hepatic pseudoaneurysmal rupture. (25536460)
2015
32
Fascioliasis simulating an intrahepatic cholangiocarcinoma-Case report with imaging and pathology correlation. (25713810)
2015
33
Performance of a 27 kDa Fasciola hepatica Antigen in the Diagnosis of Human Fascioliasis. (25949054)
2015
34
Fascioliasis: a rare cause of liver abscess. (24385589)
2014
35
Seroprevalence of human fascioliasis using indirect ELISA in isfahan district, central iran in 2013. (25759726)
2014
36
Neurological and ocular fascioliasis in humans. (24480313)
2014
37
Molecular and Morphological Characterization of Fasciola spp. Isolated from Different Host Species in a Newly Emerging Focus of Human Fascioliasis in Iran. (25018891)
2014
38
Fascioliasis. (24903364)
2014
39
Distribution and abundance of schistosomiasis and fascioliasis host snails along the Mara River in Kenya and Tanzania. (25405008)
2014
40
Impact of climate change and man-made irrigation systems on the transmission risk, long-term trend and seasonality of human and animal fascioliasis in Pakistan. (24893010)
2014
41
Fasciola gigantica transmission in the zoonotic fascioliasis endemic lowlands of Guilan, Iran: experimental assessment. (25095734)
2014
42
Severe iron deficiency anemia and marked eosinophilia in adolescent girls with the diagnosis of human fascioliasis. (25341606)
2014
43
Finding of biliary fascioliasis by endoscopic ultrasonography in a patient with eosinophilic liver abscess. (25473389)
2014
44
Fascioliasis and eosinophilia in the highlands of cuzco, peru and their association with water and socioeconomic factors. (25200257)
2014
45
Cutaneous images of interest of fascioliasis from India. (25118759)
2014
46
An incidental case of biliary fascioliasis mimicking cholangiocellular carcinoma. (25551848)
2014
47
Sonographic findings of hepatobiliary fascioliasis accompanied by extrahepatic expansion and ectopic lesions. (25425366)
2014
48
Diagnosis of human fascioliasis by stool and blood techniques: update for the present global scenario. (25077569)
2014
49
Fascioliasis: A worldwide parasitic disease of importance in travel medicine. (25287722)
2014
50
Immunodetection of Fasciola gigantica circulating antigen in sera of infected individuals for laboratory diagnosis of human fascioliasis. (23945158)
2013

Variations for Fascioliasis

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Expression for genes affiliated with Fascioliasis

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Search GEO for disease gene expression data for Fascioliasis.

Pathways for genes affiliated with Fascioliasis

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Pathways related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
19.6GPT, INS
29.6IFNG, IL10
39.4ALB, ALPP, INS
49.3IFNG, IL1B
59.0IFNG, INS, SELE
69.0IFNG, IL10, IL1B
79.0IFNG, IL10, IL1B
8
Show member pathways
9.0IFNG, IL10, IL1B
9
Show member pathways
9.0IFNG, IL10, IL1B
109.0IFNG, IL10, IL1B
119.0IFNG, IL10, IL1B
129.0IFNG, IL10, IL1B
13
Show member pathways
9.0IFNG, IL10, IL1B
148.9IFNG, IL1B, INS
15
Show member pathways
8.8IFNG, IL1B, SELE
16
Show member pathways
8.6ALB, IFNG, IL1B, INS
17
Show member pathways
8.5CTSL, IFNG, IL1B
188.5CTSL, IFNG, IL1B
198.4IFNG, IL10, IL1B, SELE
208.4IFNG, IL10, IL1B, SELE
218.0CTSL, IFNG, IL1B, SELE
22
Show member pathways
7.7CTSL, IFNG, IL10, IL1B, INS

GO Terms for genes affiliated with Fascioliasis

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Cellular components related to Fascioliasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.8ALB, CP, CTSL, IFNG, IL10, IL1B
2extracellular spaceGO:00056156.1ALB, CP, CTSL, GPT, IFNG, IL10

Biological processes related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytokine secretionGO:005071510.3IL10, INS
2defense response to protozoanGO:004283210.2IFNG, IL10
3negative regulation of growth of symbiont in hostGO:004413010.2IFNG, IL10
4positive regulation of MHC class II biosynthetic processGO:004534810.2IFNG, IL10
5positive regulation of heterotypic cell-cell adhesionGO:003411610.1IL10, IL1B
6negative regulation of lipid catabolic processGO:005099510.0IL1B, INS
7positive regulation of mitotic nuclear divisionGO:004584010.0IL1B, INS
8positive regulation of calcidiol 1-monooxygenase activityGO:006055910.0IFNG, IL1B
9positive regulation of chemokine biosynthetic processGO:004508010.0IFNG, IL1B
10positive regulation of interleukin-6 biosynthetic processGO:00454109.9IFNG, IL1B
11positive regulation of membrane protein ectodomain proteolysisGO:00510449.9IFNG, IL1B
12regulation of defense response to virus by hostGO:00506919.9IFNG, IL1B
13positive regulation of nitric oxide biosynthetic processGO:00454299.5IFNG, IL1B, INS
14response to lipopolysaccharideGO:00324969.0IL10, IL1B, SELE

Sources for Fascioliasis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet