MCID: FSC002
MIFTS: 42

Fascioliasis malady

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Fascioliasis

Aliases & Descriptions for Fascioliasis:

Name: Fascioliasis 12 50 52 3 42 14 69
Fasciola Hepatica Infection 12 69
Sheep Liver Fluke Infection 12
Infection by Fasciola 12
Liver Flukes Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:885
ICD10 33 B66.3
ICD9CM 35 121.3
MeSH 42 D005211
SNOMED-CT 64 111922007 187125007
UMLS 69 C0015652

Summaries for Fascioliasis

CDC : 3 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as "the common liver fluke" or "the sheep liver fluke." A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all 5 continents, in over 50 countries, especially where sheep or cattle are reared. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The immature larval flukes migrate through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes, which produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards based summary : Fascioliasis, also known as fasciola hepatica infection, is related to hepatitis and gastric neuroendocrine tumor type 1. An important gene associated with Fascioliasis is SLC17A5 (Solute Carrier Family 17 Member 5), and among its related pathways/superpathways are Allograft rejection and Toxoplasmosis. Affiliated tissues include liver, lung and testes, and related phenotypes are liver/biliary system and vision/eye

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Related Diseases for Fascioliasis

Diseases related to Fascioliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
id Related Disease Score Top Affiliating Genes
1 hepatitis 10.3
2 gastric neuroendocrine tumor type 1 10.3 GPT SLC17A5
3 radiation induced cancer 10.3 GPT SLC17A5
4 jejunal neuroendocrine tumor 10.3 ALPP GPT
5 neurological manifestations of pompe disease 10.2 ALB CP
6 schistosomiasis 10.2
7 female infertility of uterine origin 10.2 ALB GPT SLC17A5
8 retinal arterial macroaneurysm with supravalvular pulmonic stenosis 10.2 ALB GPT SLC17A5
9 acute monocytic leukemia 10.2 ALB GPT SLC17A5
10 bile duct cystadenocarcinoma 10.2 ALB ALPP GPT
11 submucous uterine fibroid 10.2 ALB INS
12 congenital hypoplastic anemia 10.2 ALB GPT SLC17A5
13 hypersensitivity syndrome, carbamazepine-induced 10.2 ALB INS
14 noninfectious dermatoses of eyelid 10.2 ALB GPT SLC17A5
15 asymptomatic neurosyphilis 10.2 IFNG IL10
16 bladder sarcoma 10.1 ALB CP GPT
17 not otherwise specified 3-mga-uria type 10.1 GPT INS SLC17A5
18 auditory neuropathy, autosomal dominant, 1 10.1 ALB CP GPT
19 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.1 IFNG IL10
20 tungiasis 10.1 IFNG IL10
21 benign deep fibrous histiocytoma 10.1 ALB GPT IFNG
22 israeli tick typhus 10.1 IFNG SELE
23 hemolytic-uremic syndrome 10.1 ALB GPT IFNG
24 pulpitis 10.1 IFNG IL10 SLC17A5
25 lymphoblastic lymphoma 10.1 ALB GPT SLC17A5
26 kohler's disease 10.1 ALB ALPP GPT SLC17A5
27 paranasal sinus sarcoma 10.1 ALB ALPP GPT SLC17A5
28 laryngotracheoesophageal cleft type 2 10.1 IL1B SLC17A5
29 de quervain disease 10.1 CP SELE
30 ciliary discoordination, due to random ciliary orientation 10.1 ALB IFNG IL10
31 stocco dos santos syndrome 10.1 IFNG IL1B
32 lipid metabolism disorder 10.1 IFNG INS
33 non-gestational choriocarcinoma 10.1 ALB IFNG IL10
34 plummer's disease 10.1 ALB IFNG IL10
35 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.1 IL1B SELE
36 depressed scar 10.1 ALB IFNG IL10
37 mansonelliasis 10.1 ALB IFNG IL10
38 paratyphoid fever 10.0 ALB IFNG IL10
39 liver inflammatory pseudotumor 10.0 ALB IFNG IL10
40 amelogenesis imperfecta 10.0 ALB GPT IL10 SLC17A5
41 uterus interstitial leiomyoma 10.0 ALB IFNG IL10
42 hyperuricemia, pulmonary hypertension, renal failure, and alkalosis 10.0 ALB IL10 SELE
43 glucosephosphate dehydrogenase deficiency 10.0 ALB IL1B
44 scleral disease 10.0 ALB IFNG IL10
45 giant cell glioblastoma 10.0 IFNG IL1B
46 periarthritis 10.0 CP IFNG IL10
47 chordoid meningioma 10.0 ALB IL10 IL1B
48 breast apocrine carcinoma in situ 10.0 ALB IL10 IL1B
49 denys-drash syndrome 10.0 IFNG IL10 INS
50 unilateral hypoactive labyrinth 10.0 ALB IL10 IL1B

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to Fascioliasis

Symptoms & Phenotypes for Fascioliasis

MGI Mouse Phenotypes related to Fascioliasis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.43 ALB CP IFNG IL10 INS SELE
2 vision/eye MP:0005391 9.1 SLC17A5 CP IFNG IL10 INS SELE

Drugs & Therapeutics for Fascioliasis

Search Clinical Trials , NIH Clinical Center for Fascioliasis

Cochrane evidence based reviews: fascioliasis

Genetic Tests for Fascioliasis

Anatomical Context for Fascioliasis

MalaCards organs/tissues related to Fascioliasis:

39
Liver, Lung, Testes, T Cells, Brain, Endothelial, Skin

Publications for Fascioliasis

Articles related to Fascioliasis:

(show top 50) (show all 541)
id Title Authors Year
1
First Report of Human Fascioliasis in an Endemic Region of Bovine Fascioliasis in Caldas-Colombia. ( 27045315 )
2016
2
Evaluation of modified Dennis parasitological technique for diagnosis of bovine fascioliasis. ( 27622626 )
2016
3
Animal Fascioliasis: Perspectives from high altitudinal regions. ( 27890078 )
2016
4
Human fascioliasis endemic areas in Argentina: multigene characterisation of the lymnaeid vectors and climatic-environmental assessment of the transmission pattern. ( 27229862 )
2016
5
Treatment Failure after Multiple Courses of Triclabendazole among Patients with Fascioliasis in Cusco, Peru: A Case Series. ( 26808543 )
2016
6
Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in blood samples diagnosed in Medic Medical Center Laboratory, Ho Chi Minh City, Vietnam in 2012. ( 27595647 )
2016
7
A pediatric case of Fascioliasis with eosinophilic pneumonia. ( 27922247 )
2016
8
Epidemiological analysis of human fascioliasis in northeastern Punjab, Pakistan. ( 26763724 )
2016
9
Evaluation of patients diagnosed with fascioliasis: A six-year experience at a university hospital in Turkey. ( 27131001 )
2016
10
Development of Two FhSAP2 Recombinant-Based Assays for Immunodiagnosis of Human Chronic Fascioliasis. ( 27549636 )
2016
11
Seroprevalence of Human Fascioliasis in Chaharmahal and Bakhtiyari Province, Southwestern Iran. ( 27648421 )
2016
12
Access to, and use of, water by populations living in a schistosomiasis and fascioliasis co-endemic area of northern CA'te d'Ivoire. ( 26004285 )
2015
13
Familial Trichostrongylus Infection Misdiagnosed as Acute Fascioliasis. ( 26402161 )
2015
14
CLINICOPATHOLOGIC CORRELATES OF FASCIOLIASIS IN TWO EASTERN GREY KANGAROOS (MACROPUS GIGANTEUS). ( 26667560 )
2015
15
Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children. ( 26312936 )
2015
16
Human Fascioliasis: A Re-emerging Disease in Upper Egypt. ( 25870421 )
2015
17
The Status of Human and Animal Fascioliasis in Iran: A Narrative Review Article. ( 26622287 )
2015
18
Endoscopic Extraction of Biliary Fascioliasis Diagnosed Using Intraductal Ultrasonography in a Patient with Acute Cholangitis. ( 26668810 )
2015
19
Fascioliasis: An Ongoing Zoonotic Trematode Infection. ( 26417603 )
2015
20
Pathology in practice. Distomiasis (fascioliasis) in a New Mexico Dahl sheep. ( 26043127 )
2015
21
Screening for Zoonotic Fascioliasis in Slaughtered Large Ruminants in Abattoirs in Perak, Malaysia. ( 26868715 )
2015
22
A Case of Fascioliasis Treated Successfully Without Sequelae in a Japanese Expatriate Living in Jakarta. ( 26309420 )
2015
23
Epidemiology of Human Fascioliasis and Intestinal Helminthes in Rural Areas of Boyer-Ahmad Township, Southwest Iran; A Population Based Study. ( 26744710 )
2015
24
Developing a climate-based risk map of fascioliasis outbreaks in Iran. ( 25982974 )
2015
25
Diagnosis of human fascioliasis in Arusha region, northern Tanzania by microscopy and clinical manifestations in patients. ( 26695775 )
2015
26
Biochemical assessment of oxidative status versus liver enzymes in patients with chronic fascioliasis. ( 26688624 )
2015
27
Biliary Fascioliasis Diagnosed on EUS. ( 26394385 )
2015
28
The Endemicity of Human Fascioliasis in Guilan Province, Northern Iran: the Baseline for Implementation of Control Strategies. ( 26056669 )
2015
29
Fascioliasis in Australian travellers to Bali. ( 26268290 )
2015
30
Seroprevalence of human fascioliasis in Van province, Turkey. ( 26006203 )
2015
31
Education and imaging. Hepatology: Fascioliasis: a rare cause of hepatic pseudoaneurysmal rupture. ( 25536460 )
2015
32
Fascioliasis simulating an intrahepatic cholangiocarcinoma-Case report with imaging and pathology correlation. ( 25713810 )
2015
33
Performance of a 27 kDa Fasciola hepatica Antigen in the Diagnosis of Human Fascioliasis. ( 25949054 )
2015
34
Fascioliasis: a rare cause of liver abscess. ( 24385589 )
2014
35
Seroprevalence of human fascioliasis using indirect ELISA in isfahan district, central iran in 2013. ( 25759726 )
2014
36
Neurological and ocular fascioliasis in humans. ( 24480313 )
2014
37
Molecular and Morphological Characterization of Fasciola spp. Isolated from Different Host Species in a Newly Emerging Focus of Human Fascioliasis in Iran. ( 25018891 )
2014
38
Fascioliasis. ( 24903364 )
2014
39
Distribution and abundance of schistosomiasis and fascioliasis host snails along the Mara River in Kenya and Tanzania. ( 25405008 )
2014
40
Impact of climate change and man-made irrigation systems on the transmission risk, long-term trend and seasonality of human and animal fascioliasis in Pakistan. ( 24893010 )
2014
41
Fasciola gigantica transmission in the zoonotic fascioliasis endemic lowlands of Guilan, Iran: experimental assessment. ( 25095734 )
2014
42
Severe iron deficiency anemia and marked eosinophilia in adolescent girls with the diagnosis of human fascioliasis. ( 25341606 )
2014
43
Finding of biliary fascioliasis by endoscopic ultrasonography in a patient with eosinophilic liver abscess. ( 25473389 )
2014
44
Fascioliasis and eosinophilia in the highlands of cuzco, peru and their association with water and socioeconomic factors. ( 25200257 )
2014
45
Cutaneous images of interest of fascioliasis from India. ( 25118759 )
2014
46
An incidental case of biliary fascioliasis mimicking cholangiocellular carcinoma. ( 25551848 )
2014
47
Sonographic findings of hepatobiliary fascioliasis accompanied by extrahepatic expansion and ectopic lesions. ( 25425366 )
2014
48
Diagnosis of human fascioliasis by stool and blood techniques: update for the present global scenario. ( 25077569 )
2014
49
Fascioliasis: A worldwide parasitic disease of importance in travel medicine. ( 25287722 )
2014
50
Immunodetection of Fasciola gigantica circulating antigen in sera of infected individuals for laboratory diagnosis of human fascioliasis. ( 23945158 )
2013

Variations for Fascioliasis

Expression for Fascioliasis

Search GEO for disease gene expression data for Fascioliasis.

Pathways for Fascioliasis

Pathways related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 22)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.46 CTSL IFNG IL10 IL1B INS
2
Show member pathways
12.05 IFNG IL10 IL1B
3
Show member pathways
12.04 ALB IFNG IL1B INS
4 12.03 IFNG IL10 IL1B
5
Show member pathways
11.97 CTSL IFNG IL1B
6
Show member pathways
11.94 IFNG IL10 IL1B
7 11.87 ALB ALPP INS
8
Show member pathways
11.74 IFNG IL10 IL1B
9 11.73 IFNG IL1B INS
10 11.7 CTSL IFNG IL1B SELE
11 11.67 IFNG IL10 IL1B
12 11.63 CTSL IFNG IL1B
13 11.56 IFNG IL10 IL1B
14 11.51 IFNG IL10 IL1B
15
Show member pathways
11.41 IFNG IL1B SELE
16 11.28 IFNG INS SELE
17 11.01 IFNG IL10
18 10.98 IFNG IL1B
19 10.95 IFNG IL10 IL1B SELE
20 10.81 IFNG IL10 IL1B
21 10.75 GPT INS
22 10.47 IFNG IL10 IL1B SELE

GO Terms for Fascioliasis

Cellular components related to Fascioliasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 ALB CP CTSL IFNG IL10 IL1B
2 extracellular space GO:0005615 9.28 ALB CP CTSL GPT IFNG IL10

Biological processes related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.71 IL10 IL1B SELE
2 positive regulation of cytokine secretion GO:0050715 9.52 IL10 INS
3 positive regulation of mitotic nuclear division GO:0045840 9.51 IL1B INS
4 defense response to protozoan GO:0042832 9.49 IFNG IL10
5 negative regulation of lipid catabolic process GO:0050995 9.48 IL1B INS
6 negative regulation of growth of symbiont in host GO:0044130 9.46 IFNG IL10
7 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.43 IFNG IL1B
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.4 IL10 IL1B
9 positive regulation of chemokine biosynthetic process GO:0045080 9.37 IFNG IL1B
10 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.32 IFNG IL1B
11 regulation of defense response to virus by host GO:0050691 9.26 IFNG IL1B
12 positive regulation of MHC class II biosynthetic process GO:0045348 9.16 IFNG IL10
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.13 IFNG IL1B INS
14 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.62 IFNG IL1B

Sources for Fascioliasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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