MCID: FSC002
MIFTS: 39

Fascioliasis malady

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Fascioliasis

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Aliases & Descriptions for Fascioliasis:

Name: Fascioliasis 10 45 47 12 36 2 65
Fasciola Hepatica Infection 10 65
Sheep Liver Fluke Infection 10
 
Infection by Fasciola 10
Liver Flukes Nos 10

Classifications:



External Ids:

Disease Ontology10 DOID:885
ICD1027 B66.3
ICD9CM29 121.3
MeSH36 D005211
UMLS65 C0015652, C1331532

Summaries for Fascioliasis

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CDC:2 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as "the common liver fluke" or "the sheep liver fluke." A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all 5 continents, in over 50 countries, especially where sheep or cattle are reared. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The immature larval flukes migrate through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes, which produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards based summary: Fascioliasis, also known as fasciola hepatica infection, is related to breast cancer and kartagener syndrome. An important gene associated with Fascioliasis is ALPP (Alkaline Phosphatase, Placental), and among its related pathways are African trypanosomiasis and Malaria. Affiliated tissues include liver, lung and breast.

Disease Ontology:10 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Related Diseases for Fascioliasis

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Diseases related to Fascioliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 361)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer10.3
2kartagener syndrome10.3ALPP, IL1B
3thyroiditis10.3
4pleomorphic adenoma carcinoma10.3ALPP, IL1B
5graphite pneumoconiosis10.2CP, INS
6benign focal amyotrophy10.2ALPP, IL1B
7casp10-related autoimmune lymphoproliferative syndrome10.2INS, SELE
8duodenum cancer10.2IL1B, SELE
9hepatocellular carcinoma10.2
10prostatitis10.2
11pancreatitis10.2
12prostate cancer10.2
13arthritis10.2
14leukemia10.2
15neuronitis10.2
16gestational diabetes10.2INS, SELE
17atypical teratoid rhabdoid tumor10.1ALPP, CTSL
18adenocarcinoma10.1
19granulomatous amebic encephalitis10.1CTSL, IL1B
20food allergy10.1IL1B, SELE
21mixed mineral dust pneumoconiosis10.1CP, IL1B
22bone cancer10.1IL1B, INS
23diphyllobothriasis10.1MT-CO1, SELE
24rheumatoid arthritis10.1
25colorectal cancer10.1
26pulmonary hypertension10.1
27lymphoma10.1
28dementia10.1
29pneumonia10.1
30endotheliitis10.1
31rectum signet ring adenocarcinoma10.1ALPP, IL1B
32mobitz type ii atrioventricular block10.1IL1B, MT-CO1
33mitochondrial metabolism disease10.1ALPP, IL1B, SELE
34matsoukas liarikos giannika syndrome10.1INS, MT-CO1
35long bone adamantinoma10.1IL1B, SELE
36systemic lupus erythematosus10.0
37lung cancer10.0
38atherosclerosis10.0
39nephrotic syndrome10.0
40esophagitis10.0
41melanoma10.0
42endophthalmitis10.0
43lupus erythematosus10.0
44amyloidosis10.0
45cardiomyopathy10.0
46giardiasis10.0CTSF, MT-CO1
47pheochromocytoma9.9
48asthma9.9
49coronary artery disease9.9
50renal cell carcinoma9.9

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to fascioliasis

Symptoms for Fascioliasis

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Drugs & Therapeutics for Fascioliasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Fascioliasis


Cochrane evidence based reviews: fascioliasis

Genetic Tests for Fascioliasis

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Anatomical Context for Fascioliasis

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MalaCards organs/tissues related to Fascioliasis:

33
Liver, Lung, Breast, T cells, Kidney, Ovary, Prostate

Animal Models for Fascioliasis or affiliated genes

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Publications for Fascioliasis

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Articles related to Fascioliasis:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
Reliability and Validity of the Korean Version of the Symptom Checklist-Post-Traumatic Stress Disorder Scale. (27134501)
2016
2
Genetic Variants in the Vitamin D Pathway Genes VDBP and RXRA Modulate Cutaneous Melanoma Disease-Specific Survival. (26575331)
2015
3
The integrative role of leptin, oestrogen and the insulin family in obesity-associated breast cancer: potential effects of exercise. (25875578)
2015
4
HLA-DQA1 and PLA2R1 polymorphisms and risk of idiopathic membranous nephropathy. (24262501)
2014
5
Sinusoidal obstruction syndrome (hepatic veno-occlusive disease). (25755580)
2014
6
The second deletion mutation in exon 8 of EDA gene in an XLHED pedigree. (23635427)
2013
7
Elevated norepinephrine may be an etiological factor in a wide range of diseases: age-related macular degeneration, systemic lupus erythematosus, atrial fibrillation, metabolic syndrome. (23410497)
2013
8
Evaluation of the rapid loop-mediated isothermal amplification assay Illumigene for diagnosis of Clostridium difficile in an outbreak situation. (23758095)
2013
9
Diagnosis and treatment of benign multicystic peritoneal mesothelioma. (24151400)
2013
10
A systemic assessment of the association between tumor necrosis factor alpha 308 G/A polymorphism and risk of cervical cancer. (23494178)
2013
11
Deletions in 16q24.2 are associated with autism spectrum disorder, intellectual disability and congenital renal malformation. (23335808)
2013
12
Budesonide versus prednisone with azathioprine for the treatment of autoimmune hepatitis in children and adolescents. (23810723)
2013
13
Signaling pathways of PAX2 and its role in renal interstitial fibrosis and glomerulosclerosis. (23137159)
2012
14
Alveolar echinococcosis of the adrenal gland: brief review of two cases. (22800838)
2012
15
Miller-Fisher syndrome following vaccination against influenza virus A/H1N1 in an AIDS patient. (21877180)
2012
16
Study on the nuclear translocation mechanism in the inhibition of nuclear factor-I9B activation in bacterial lipoprotein-tolerant THP-1 cells]. (21549062)
2011
17
Blood cells from Friedreich ataxia patients harbor frataxin deficiency without a loss of mitochondrial function. (21147271)
2011
18
Cardiac resynchronization therapy and obstructive sleep-related breathing disorder in patients with congestive heart failure. (21609340)
2011
19
Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study. (21750656)
2011
20
Oral presentation of malignant mesothelioma. (20813558)
2011
21
11-Year follow-up in biliopancreatic diversion for recurrent pancreatitis due to lipoprotein lipase deficiency. (21415674)
2011
22
A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration. (20493808)
2010
23
Transitional cell tumors of the ovary: a comparative clinicopathologic, immunohistochemical, and molecular genetic analysis of Brenner tumors and transitional cell carcinomas. (19033864)
2009
24
The transcription elongation factors NELF, DSIF and P-TEFb control constitutive transcription in a gene-specific manner. (19654008)
2009
25
Bronchiectasis and immune deficiency in an adult patient with deletion 2q37 due to an unbalanced translocation t(2;10). (19272308)
2009
26
Relapsing polychondritis in a patient with lupus erythematosus: another manifestation of neutrophilic lupus? (18594144)
2008
27
Prominent expression of metalloproteinases in early stages of ovarian tumorigenesis. (17131304)
2007
28
Endovascular management of cerebral aneurysms: work in progress. (17352339)
2007
29
Antineoplastic treatment and venous thrombosis]. (16517415)
2006
30
Second-Line docetaxel and gemcitabine combination chemotherapy in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy: a phase II trial. (15456950)
2004
31
Gaucher disease: clinical, genetic and therapeutic aspects]. (15261378)
2004
32
Holmium laser thermal keratoplasty for hyperopia in eyes overcorrected with laser in situ keratomileusis for myopia. (15188903)
2004
33
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers. (11914601)
2002
34
Low plasma levels of hemostatic proteins during the induction phase in children with acute lymphoblastic leukemia: A retrospective study by the JACLS. Japan Association of Childhood Leukemia Study. (11982900)
2002
35
A gene study on multidrug resistance of retinoblastoma]. (11864431)
2001
36
Angiotensin II initiates tyrosine kinase Pyk2-dependent signalings leading to activation of Rac1-mediated c-Jun NH2-terminal kinase. (10856308)
2000
37
Activation of C-C beta-chemokines in human peripheral blood gammadelta T cells by isopentenyl pyrophosphate and regulation by cytokines. (10607682)
2000
38
Neurological phenotype in Waardenburg syndrome type 4 correlates with novel SOX10 truncating mutations and expression in developing brain. (10762540)
2000
39
fhit Alterations in endometrial carcinoma and hyperplasia. (10652418)
2000
40
Insulin resistance and hypertension. (10423110)
1999
41
Clinical efficacy of acarbose in diabetes mellitus: a critical review of controlled trials. (9805641)
1998
42
Deep-vein thrombosis and coumarin skin necrosis associated with a factor V inhibitor with lupus-like features. (9462552)
1998
43
Distal arthrogryposis, ectodermal dysplasia and dilated cardiomyopathy--a new syndrome? (9689995)
1998
44
Pseudotype formation of Moloney murine leukemia virus with Sendai virus glycoprotein F. (9573308)
1998
45
The impact of interindividual variation in NAT2 activity on benzidine urinary metabolites and urothelial DNA adducts in exposed workers. (8643532)
1996
46
Failure to detect Epstein-Barr virus DNA in peripheral blood mononuclear cells of most patients with large granular lymphocyte leukemia. (8387836)
1993
47
Heterogenous expression and putative structure of human monocyte/macrophage serine esterase 1. (1565841)
1992
48
Nontraumatic intradiploic arachnoid cysts--report of five cases. (1282679)
1992
49
Cerebral vasospasm and vasoconstriction caused by endothelin. (1876245)
1991
50
Neuroendocrine effects of benzodiazepines. (1980690)
1990

Variations for Fascioliasis

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Expression for genes affiliated with Fascioliasis

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Search GEO for disease gene expression data for Fascioliasis.

Pathways for genes affiliated with Fascioliasis

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Pathways related to Fascioliasis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7IL1B, SELE
29.7IL1B, SELE
39.6INS, SELE

GO Terms for genes affiliated with Fascioliasis

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Biological processes related to Fascioliasis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of nitric oxide biosynthetic processGO:004542910.0IL1B, INS
2negative regulation of lipid catabolic processGO:005099510.0IL1B, INS
3positive regulation of mitotic nuclear divisionGO:00458409.9IL1B, INS
4wound healingGO:00420609.8IL1B, INS
5regulation of insulin secretionGO:00507969.6IL1B, INS
6response to copper ionGO:00466889.5CP, MT-CO1
7agingGO:00075688.8CP, IL1B, MT-CO1

Sources for Fascioliasis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet