MCID: FSC002
MIFTS: 54

Fascioliasis malady

Infectious diseases, Liver diseases categories

Summaries for Fascioliasis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Fascioliasis is a parasitic infection typically caused by Fasciola hepatica, which is also known as "the common liver fluke" or "the sheep liver fluke." A related parasite, Fasciola gigantica, also can infect people. Fascioliasis is found in all 5 continents, in over 50 countries, especially where sheep or cattle are reared. People usually become infected by eating raw watercress or other water plants contaminated with immature parasite larvae. The immature larval flukes migrate through the intestinal wall, the abdominal cavity, and the liver tissue, into the bile ducts, where they develop into mature adult flukes, which produce eggs. The pathology typically is most pronounced in the bile ducts and liver. Fasciola infection is both treatable and preventable.

MalaCards: Fascioliasis, also known as fasciola hepatica infection, is related to hepatitis and schistosomiasis. An important gene associated with Fascioliasis is SLC17A5 (solute carrier family 17 (acidic sugar transporter), member 5), and among its related pathways are Codeine and morphine metabolism and Ifosfamide Pathway, Pharmacokinetics. The compounds troleandomycin and aminopyrine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and testes.

Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by fasciola hepatica or fasciola gigantica. during the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.

Wikipedia:63 Fasciolosis also known as Fascioliasis, Fasciolasis, distomatosis and liver rot, is an important... more...

Aliases & Classifications for Fascioliasis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Liver diseases


Aliases & Descriptions:

fascioliasis 8 42 10 44 60
fasciola hepatica infection 8 60
sheep liver fluke infection 8
infection by fasciola 8
liver flukes nos 8


External Ids:

Disease Ontology8 DOID:885
ICD9CM27 121.3
MeSH34 D005211
ICD1025 B66.3

Related Diseases for Fascioliasis

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17GeneCards, 18GeneDecks
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Diseases related to Fascioliasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.0GUSB, SLC17A5, GGT1
2schistosomiasis30.8FABP12, GUSB, EPGN, RNASE3
3hepatitis a30.3GOT2
4hepatitis c30.3GOT2, GGT1, SLC17A5, CYP2A6
5pancreatitis30.3SLC17A5, GGT1, GOT2, ALPP
6opisthorchiasis30.2GGT1, EPGN
7obstructive jaundice29.8GGT1, ALPP
8cholestasis29.8SLC17A5, GGT1, GOT2, ALPP
9von hippel-lindau disease10.3
10peritonitis10.2
11paragonimiasis10.2
12dicrocoeliasis10.1
13clonorchiasis10.1
14cysticercosis10.0
15skin disease10.0ALPP
16autoimmune hepatitis10.0CYP2D7P1
17hypercholesterolemia10.0SLC17A5, GGT1
18neonatal hemochromatosis10.0SLC17A5, GGT1
19diarrhea10.0GOT2, ALPP
20extrahepatic cholestasis10.0GGT1, ALPP
21fatty liver disease10.0GGT1, GOT2
22substance abuse10.0GOT2, GGT1
23lung cancer10.0CYP2D7P1, CYP2A6
24sinusitis10.0RNASE3
25gallbladder disease10.0GOT2, GGT1
26parkinson's disease10.0CYP2D7P1
27intrahepatic cholestasis10.0ALPP, GGT1, SLC17A5
28biliary atresia10.0GGT1
29cholelithiasis10.0ALPP, GGT1, GUSB
30galactosemia10.0SLC17A5, GGT1, ALPP
31hypertension10.0GGT1, CYP2J2
32myocardial infarction10.0GOT2, FABP12
33primary biliary cirrhosis10.0SLC17A5, GGT1, ALPP
34alcoholic liver cirrhosis10.0CYP2A6, SLC17A5, GGT1
35choledocholithiasis10.0ALPP, GGT1, SLC17A5, GUSB
36congenital stationary night blindness, type 1f10.0GUSB, SLC17A5, GGT1, ALPP
37viral hepatitis10.0GGT1, SLC17A5, CYP2A6
38scrub typhus10.0SLC17A5
39periodontal disease10.0GUSB, SLC17A5, ALPP
40cholangitis10.0SLC17A5, GGT1, GOT2, ALPP
41leukopenia10.0ALPP, GOT2, SLC17A5, GUSB
42liver cirrhosis10.0ALPP, GGT1, SLC17A5, CYP2A6
43thrombocytopenia10.0GUSB, SLC17A5, GOT2, ALPP
44atherosclerosis10.0FABP12, CYP2B6, CYP2J2, GGT1
45diabetes mellitus10.0GGT1, GOT2, ALPP
46type 2 diabetes mellitus10.0GGT1, SLC17A5, GUSB, FABP12
47gilbert syndrome10.0UGT3A1, UGT3A2, UGT2A3, UGT2A1, UGT2B11
48cystic fibrosis10.0RNASE3, GUSB
49psoriasis10.0GUSB, RNASE3
50tuberculosis10.0CYP2B6, CYP2A6, GUSB

Graphical network of the top 20 diseases related to Fascioliasis:



Diseases related to fascioliasis

Clinical Features for Fascioliasis

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Drugs & Therapeutics for Fascioliasis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Fascioliasis

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Anatomical Context for Fascioliasis

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32MalaCards
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MalaCards organs/tissues related to Fascioliasis:

32
Liver, Lung, Testes, T cells, Brain, Skin, Pancreas, Eye, Kidney, Colon, Spleen, Endothelial

Animal Models for Fascioliasis or affiliated genes

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Publications for Fascioliasis

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50PubMed
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Articles related to Fascioliasis:

(show top 50)    (show all 492)
idTitleAuthorsYear
1
Investigation of the roles of fascioliasis and food allergy in intrahepatic eosinophilic proliferative pylephlebitis in Japanese Black cattle. (23131780)
2013
2
Assessing the validity of an ELISA test for the serological diagnosis of human fascioliasis in different epidemiological situations. (22413850)
2012
3
Biliary fascioliasis--an uncommon cause of recurrent biliary colics: report of a case and brief review. (22566787)
2012
4
Point prevalence of bovine fascioliasis and the influence of chemotherapy on the milk yield in a lactating bovine population from the district of Toba Tek Singh, Pakistan. (21062526)
2011
5
Characterisation of fascioliasis lymnaeid intermediate hosts from Chile by DNA sequencing, with emphasis on Lymnaea viator and Galba truncatula. (21933653)
2011
6
Cholangiocarcinoma in magnetic resonance cholangiopancreatography and fascioliasis in endoscopic ultrasonography. (22110417)
2011
7
An unexpected parasitic cause of hypereosinophilia: fascioliasis. (21534353)
2011
8
Unusual cause of biliary obstruction: hepatobiliary fascioliasis. (21563663)
2011
9
Endoscopic management of biliary fascioliasis: a case report. (20205932)
2010
10
Biliary fascioliasis mimicking sphincter of Oddi dysfunction. (20224481)
2010
11
Chapter 2. Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control. (19622408)
2009
12
Imported human fascioliasis, United Kingdom. (19891898)
2009
13
The effect of abiotic factors on the toxicity of cypermethrin against the snail Lymnaea acuminata in the control of fascioliasis. (18922205)
2009
14
Immune suppression in advanced chronic fascioliasis: an experimental study in a rat model. (17436231)
2007
15
Fascioliasis: a report of five cases presenting with common bile duct obstruction. (16421437)
2006
16
The clinical picture of hepatitis C virus as a concomitant infection with fascioliasis. (16605099)
2006
17
Control of human fascioliasis by selective chemotherapy: design, cost and effect of the first public health, school-based intervention implemented in endemic areas of the Nile Delta, Egypt. (15935413)
2005
18
Fascioliasis imported to Norway. (16012024)
2005
19
Fascioliasis among local and imported sheep in Saudi Arabia: parasitological and serological diagnosis. (16363289)
2005
20
Liver, spleen, pancreas and kidney involvement by human fascioliasis: imaging findings. (15294025)
2004
21
Human and animal fascioliasis in Mazandaran province, northern Iran. (15338292)
2004
22
Correlation between snails and fish in fish ponds of World Fish Center (ICLARM) with special reference to snail vectors of schistosomiasis and fascioliasis. (14964656)
2003
23
Hyperendemic fascioliasis associated with schistosomiasis in villages in the Nile Delta of Egypt. (14640504)
2003
24
Efficacy of Mirazid (Commiphora molmol) against fascioliasis in Egyptian sheep. (14708862)
2003
25
Molecular phylogenetic relationships in the aquatic snail genus Lymnaea, the intermediate host of the causative agent of fascioliasis: insights from broader taxon sampling. (12107463)
2002
26
Hepatic fascioliasis in the Americas: A new challenge for therapeutic endoscopy. (12145622)
2002
27
Evaluation of two serological tests in diagnosis of human cases of biliary and ectopic fascioliasis. (12049272)
2002
28
Soluble adhesion molecules as a marker of disease severity in human fascioliasis. (10946501)
2000
29
Serum pretreatment with Schistosoma mansoni antigens for serological diagnosis of fascioliasis. (10786027)
2000
30
Detection of Fasciola-specific excretory/ secretory (E/S) protein fraction band (49.5 kDa) and its utilization in diagnosis of early fascioliasis using different diagnostic techniques. (12561930)
1999
31
Studies on the molluscicidal actvity of Calendula micrantha officinalis (Compositae) on fascioliasis transmitting snails. (12561898)
1999
32
Analysis of climatic data and forecast indices for human fascioliasis at very high altitude. (10715678)
1999
33
Necrotic granuloma of the liver by human fascioliasis: imaging findings. (10475928)
1999
34
Biliary aspiration after administration of intravenous cholecystokinin for the diagnosis of hepatobiliary fascioliasis. (9564503)
1998
35
Human fascioliasis: clinical features and diagnostic difficulties in Egyptian children. (9231637)
1997
36
Detection of circulating antigens in blood to evaluate treatment of fascioliasis. (9257975)
1997
37
Fascioliasis in a pregnant woman. (8916587)
1996
38
Vaccination against schistosomiasis and fascioliasis with the new recombinant antigen Sm14: potential basis of a multi-valent anti-helminth vaccine? (8531667)
1995
39
Fascioliasis: case reports and review. (8218685)
1993
40
A case of human fascioliasis in Qualyobia Governorate. (8376878)
1993
41
Hepatic fascioliasis and biliary surgery. (1399359)
1992
42
Ultrasonographic findings in the gall bladder in human fascioliasis. (1431301)
1992
43
Sensitivity of crude and purified Fasciola antigens in immunological diagnosis of human fascioliasis. (2768848)
1989
44
Sonography in diagnosis of fascioliasis. (2566815)
1989
45
Partial purification of somatic and excretory-secretory products of adult Fasciola hepatica and their application for the serodiagnosis of experimental and natural fascioliasis using an ELISA. (6473914)
1984
46
Fascioliasis in Jamaica: epidemiologic and economic aspects of a snail-borne parasitic zoonosis. (6652318)
1983
47
Chronic subclinical fascioliasis in sheep: effects on food intake, food utilisation and blood constituents. (7375735)
1980
48
Bovine fascioliasis in Nigeria. II. Blood chemistry and its correlation with worm burdens in chronicc fascioliasis. (7468004)
1980
49
Bovine fascioliasis in Nigeria. I. Haematological indices and their correlation with worm burden in chronic fascioliasis. (7225773)
1980
50
The hypoalbuminaemia of ovine fascioliasis: the influence of protein intake on the albumin metabolism of infected and of pair-fed control sheep. (447441)
1979

Genetic Variations for Fascioliasis

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Expression for genes affiliated with Fascioliasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fascioliasis

Search GEO for disease gene expression data for Fascioliasis.

Pathways for genes affiliated with Fascioliasis

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37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 12EMD Millipore, 53Reactome
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Pathways related to Fascioliasis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2CYP2D7P1, CYP2B6
2
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10.2CYP2A6, CYP3A5
3
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10.2CYP2A6, CYP2B6
4
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10.1CYP2A6, CYP4X1
5
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10.1CYP2A6, CYP4X1
610.1CYP3A43, CYP3A5, CYP2J2
7
Retinol metabolism
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10.0CYP2B6, CYP2A6, CYP3A5
8
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10.0CYP3A5, CYP2A6, CYP2B6
9
Hide members
10.0GGT1, CYP2J2, CYP2B6
10
Hide members
10.0CYP2B6, CYP3A5, UGT2B11
11
Hide members
10.0CYP4X1, CYP2A6, CYP2B6
12
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9.8CYP3A43, CYP3A5, CYP2A6, CYP2B6, CYP2J2
13
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9.6CYP2J2, CYP2B6, CYP2A6, CYP4X1, CYP3A5, CYP3A43
14
Hide members
9.5GUSB, UGT2A3, UGT2A1, UGT2B11, CYP3A43, CYP3A5
15
Hide members
9.5UGT2A3, UGT2A1, UGT2B11, CYP3A43, CYP3A5, CYP2A6
16
Hide members
9.2GUSB, UGT2A3, UGT2A1, UGT2B11, CYP3A43, CYP3A5
17
Hide members
9.0GGT1, UGT2A3, UGT2A1, UGT2B11, CYP3A43, CYP3A5

Compounds for genes affiliated with Fascioliasis

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Fascioliasis according to GeneCards/GeneDecks:

(show top 50)    (show all 179)
idCompoundScoreTop Affiliating Genes
1troleandomycin44 1111.3CYP2A6, CYP3A43, CYP3A5, CYP2B6
2aminopyrine4410.3GGT1, SLC17A5, CYP2B6, CYP2A6
3praziquantel44 1111.3CYP3A5, GGT1, RNASE3, CYP3A43
4bilirubin diglucuronide44 2411.3UGT2A1, UGT2B11, UGT2A3, GUSB
5(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)2410.3UGT2A3, UGT2A1, GUSB, UGT2B11
6aldosterone 18-glucuronide44 2411.2UGT2A1, UGT2A3, GUSB, UGT2B11
7androsterone glucuronide44 2411.2UGT2A1, UGT2B11, GUSB, UGT2A3
8buprenorphine44 28 1112.2SLC17A5, CYP2A6, GUSB, CYP3A5
9azelastine44 1111.2CYP2B6, CYP3A5, CYP2A6, RNASE3
103-alpha-androstanediol glucuronide44 2411.2UGT2A1, UGT2B11, UGT2A3, GUSB
11aflatoxin b144 2411.2CYP2B6, CYP3A5, CYP2A6, SLC17A5
12chlorzoxazone44 28 1112.2GUSB, CYP2A6, CYP3A5, SLC17A5, CYP2B6
13rifampin49 1111.2CYP2A6, CYP3A5, CYP3A43, CYP2B6
14antipyrine44 1111.2CYP2B6, GUSB, CYP2A6, SLC17A5, GGT1
15nevirapine44 49 1112.2CYP2A6, CYP2B6, SLC17A5, GGT1, CYP3A5
16sevoflurane44 1111.1SLC17A5, GGT1, CYP2A6, CYP2B6, ALPP
17rifampicin44 28 5912.1CYP2B6, SLC17A5, GGT1, CYP3A5, CYP2A6
18isoflurane44 1111.1ALPP, GGT1, CYP2B6, SLC17A5
19lidocaine44 28 1112.1CYP3A5, CYP2A6, CYP2B6, SLC17A5
20carbamazepine44 49 1112.1CYP2B6, CYP3A5, ALPP, GGT1, SLC17A5
21erythromycin44 49 2 1113.1CYP3A5, CYP2A6, CYP2B6, GUSB, ALPP
22phenytoin44 49 28 1113.0CYP2A6, CYP3A5, CYP2B6, SLC17A5, GGT1, ALPP
236-hydroxymelatonin44 28 2412.0CYP3A5, CYP2J2, CYP2B6, CYP2A6, CYP4X1, CYP3A43
24paraxanthine44 2411.0CYP2B6, CYP2J2, CYP3A43, CYP3A5, CYP4X1, CYP2A6
25Formic Acid11 2411.0CYP3A43, CYP3A5, CYP2A6, CYP2B6, CYP4X1, CYP2J2
26parathion44 2411.0CYP3A43, CYP2A6, CYP4X1, CYP2B6, CYP2J2, CYP3A5
27citalopram49 44 11 2413.0CYP3A5, CYP2A6, CYP2J2, CYP2B6, CYP4X1, CYP3A43
28disulfiram44 59 1112.0GGT1, CYP2A6, SLC17A5, CYP3A5
29androstenedione44 2411.0CYP2A6, CYP3A5, CYP3A43, CYP2B6, CYP2J2, CYP4X1
30linoleic acid44 28 2412.0CYP4X1, CYP2J2, CYP2B6, CYP2A6, CYP3A5, CYP3A43
31caffeine44 49 28 2 11 2414.9CYP2A6, CYP3A43, CYP3A5, CYP2B6, CYP2J2, CYP4X1
32benzphetamine44 1110.9GUSB, CYP2B6, CYP2A6
33vitamin b12449.9GUSB, SLC17A5, GGT1, ALPP
34verapamil44 49 28 11 2413.9ALPP, CYP3A5, CYP2B6, SLC17A5, GGT1
35phenobarbital44 28 1111.9ALPP, GUSB, CYP3A5, CYP2A6, CYP2B6, SLC17A5
36heme28 11 2411.9CYP3A43, CYP2A6, CYP3A5, CYP4X1, CYP2B6, CYP2J2
37quercetin44 59 11 2412.9ALPP, GUSB, CYP2B6, GGT1, CYP2A6, UGT3A1
38formaldehyde44 2410.8CYP3A5, CYP3A43, CYP2A6, RNASE3, CYP2J2, CYP4X1
39phenacetin44 1110.7CYP2B6, CYP2A6, CYP3A5
40valproic acid44 49 11 2412.7GGT1, CYP2J2, CYP2B6, CYP2A6, CYP4X1, CYP3A5
41tamoxifen44 49 28 1112.7CYP2B6, CYP3A5, ALPP, GGT1, CYP2A6, SLC17A5
42arachidonic acid44 28 11 2412.6CYP2A6, CYP3A43, CYP3A5, CYP4X1, CYP2B6, CYP2J2
43creatinine449.6GUSB, FABP12, ALPP, GGT1, SLC17A5, CYP3A5
44estrone44 28 11 2412.6UGT2B11, UGT2A1, UGT2A3, CYP3A43, CYP3A5, CYP2J2
45nadph44 2410.6CYP3A5, CYP4X1, CYP2A6, CYP2J2, CYP2B6, CYP3A43
46estradiol44 11 2411.6UGT2B11, CYP2J2, CYP2B6, CYP2A6, CYP4X1, CYP3A5
47dexamethasone44 49 28 1112.5ALPP, GGT1, RNASE3, CYP2B6, CYP2A6, CYP3A43
48codeine44 49 28 11 2413.4CYP2A6, UGT2A1, UGT2A3, CYP2B6, GUSB, CYP4X1
49testosterone44 59 11 2412.1CYP3A5, CYP4X1, GGT1, SLC17A5, CYP2B6, CYP2A6
50retinoic acid44 2410.1ALPP, RNASE3, CYP2J2, CYP2B6, CYP3A43, CYP2A6

GO Terms for genes affiliated with Fascioliasis

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16Gene Ontology
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Cellular components related to Fascioliasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:0057899.4CYP2J2, CYP2B6, CYP2A6, CYP4X1, CYP3A5, CYP3A43

Biological processes related to Fascioliasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular glucuronidationGO:05269510.2UGT2A1, UGT2A3
2steroid metabolic processGO:0082029.9CYP2A6, CYP2B6, CYP3A5
3exogenous drug catabolic processGO:0427389.9CYP2A6, CYP2B6
4xenobiotic metabolic processGO:0068059.5GGT1, UGT2B11, CYP3A43, CYP3A5, CYP2A6, CYP2B6
5small molecule metabolic processGO:0442819.2CYP2A6, CYP2B6, CYP2J2, GGT1, GOT2, CYP3A43

Molecular functions related to Fascioliasis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:01671210.2CYP2A6, CYP2B6
2monooxygenase activityGO:00449710.0CYP3A43, CYP3A5, CYP2B6
3aromatase activityGO:0703309.9CYP2J2, CYP4X1, CYP3A5, CYP3A43
4glucuronosyltransferase activityGO:0150209.8UGT2B11, UGT2A1, UGT2A3, UGT3A2, UGT3A1
5UDP-glycosyltransferase activityGO:0081949.8UGT3A1, UGT3A2
6heme bindingGO:0200379.7CYP4X1, CYP2A6, CYP2J2, CYP3A5, CYP2B6, CYP3A43
7iron ion bindingGO:0055069.7CYP3A5, CYP2J2, CYP2B6, CYP2A6, CYP4X1, CYP3A43
8electron carrier activityGO:0090559.6CYP2J2, CYP3A43, CYP3A5, CYP4X1, CYP2B6, CYP2A6

Products for genes affiliated with Fascioliasis

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  • Antibodies
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Sources for Fascioliasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet