MCID: FTL032
MIFTS: 15

Fatal Infantile Lactic Acidosis malady

Summaries for Fatal Infantile Lactic Acidosis

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Fatal Infantile Lactic Acidosis is related to lactic acidosis and mitochondrial disorders. An important gene associated with Fatal Infantile Lactic Acidosis is SUCLG1 (succinate-CoA ligase, alpha subunit), and among its related pathways is Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The compounds inosine triphosphate and rotenone have been mentioned in the context of this disorder.

Aliases & Classifications for Fatal Infantile Lactic Acidosis

About this section
Sources:
20GeneTests
See all sources

Aliases & Descriptions:

fatal infantile lactic acidosis 20


Related Diseases for Fatal Infantile Lactic Acidosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Fatal Infantile Lactic Acidosis family:

Lactic Acidosis Congenital Infantile

Diseases related to Fatal Infantile Lactic Acidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1lactic acidosis30.9NDUFS4, MT-ND1
2mitochondrial disorders30.4MT-ND1
3complement deficiency10.3
4myopathy10.3
5mitochondrial dna depletion syndrome 910.3
6mitochondrial complex i deficiency10.0NDUFS4
7mitochondrial dna-associated leigh syndrome and narp10.0MT-ND1
8leber hereditary optic neuropathy10.0MT-ND1
9parkinson's disease10.0NDUFS4, MT-ND1

Graphical network of diseases related to Fatal Infantile Lactic Acidosis:



Diseases related to fatal infantile lactic acidosis

Clinical Features for Fatal Infantile Lactic Acidosis

About this section

Drugs & Therapeutics for Fatal Infantile Lactic Acidosis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Fatal Infantile Lactic Acidosis

Drug clinical trials:

Search ClinicalTrials for Fatal Infantile Lactic Acidosis

Search NIH Clinical Center for Fatal Infantile Lactic Acidosis

Search CenterWatch for Fatal Infantile Lactic Acidosis

Genetic Tests for Fatal Infantile Lactic Acidosis

About this section
Sources:
20GeneTests
See all sources

Genetic tests related to Fatal Infantile Lactic Acidosis:

id Genetic test Affiliating Genes
1 Fatal Infantile Lactic Acidosis20 SUCLG1

Anatomical Context for Fatal Infantile Lactic Acidosis

About this section

Animal Models for Fatal Infantile Lactic Acidosis or affiliated genes

About this section

Publications for Fatal Infantile Lactic Acidosis

About this section

Genetic Variations for Fatal Infantile Lactic Acidosis

About this section

Expression for genes affiliated with Fatal Infantile Lactic Acidosis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Fatal Infantile Lactic Acidosis

Search GEO for disease gene expression data for Fatal Infantile Lactic Acidosis.

Pathways for genes affiliated with Fatal Infantile Lactic Acidosis

About this section
Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Fatal Infantile Lactic Acidosis

About this section
Sources:
44Novoseek, 24HMDB, 28IUPHAR
See all sources

Compounds related to Fatal Infantile Lactic Acidosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1inosine triphosphate44 2410.5SUCLG1, NME4
2rotenone449.0MT-ND1, NDUFS4
3nad28 2410.0MT-ND1, NDUFS4
4pyruvate448.7MT-ND1, NDUFS4
5atp44 289.4NDUFS4, MT-ND1, NME4

GO Terms for genes affiliated with Fatal Infantile Lactic Acidosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Fatal Infantile Lactic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:0057398.6SUCLG1, NME4, NDUFS4
2mitochondrial inner membraneGO:0057438.3SUCLG1, NME4, NDUFS4

Biological processes related to Fatal Infantile Lactic Acidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular metabolic processGO:0442378.8SUCLG1, NDUFS4
2small molecule metabolic processGO:0442818.6SUCLG1, NME4, NDUFS4

Products for genes affiliated with Fatal Infantile Lactic Acidosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fatal Infantile Lactic Acidosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet