MCID: FTT001
MIFTS: 61

Fatty Liver Disease malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Fatty Liver Disease

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32MalaCards
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MalaCards: Fatty Liver Disease, also known as fatty liver, is related to obesity and hepatitis. An important gene associated with Fatty Liver Disease is PNPLA3 (patatin-like phospholipase domain containing 3), and among its related pathways are Adipogenesis and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The compounds glucose and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and testes, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Aliases & Classifications for Fatty Liver Disease

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

fatty liver disease 8 10
fatty liver 44 60
fatty liver, alcoholic 60
alcoholic fatty liver 8
fatty change of liver 8
fatty liver alcoholic 44
fatty degeneration 60
steatosis of liver 8
hepatic lipidosis 8


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Disease Ontology8 DOID:9452
ICD9CM27 571.0
ICD1025 K70.0, K76.0

Related Diseases for Fatty Liver Disease

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17GeneCards, 18GeneDecks
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Diseases related to Fatty Liver Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1obesity31.6HFE, RETN, AGRP, MTTP, APLN, RBP4
2hepatitis31.4GPT, SLC17A5
3alcoholic hepatitis31.1GPT, GGT1, SLC17A5
4atherosclerosis30.9GGT1, APLN, RBP4, RETN, ADIPOQ, MTTP
5hepatitis c30.9MTTP, GGT1, HFE, GPT, SLC17A5, RBP4
6diabetes mellitus30.8HFE, GGT1, GPT, FGF21, RETN, RBP4
7hypertension30.8LEP, RETN, GGT1
8type 2 diabetes mellitus30.8FGF21, GPT, LEP, SLC17A5, GGT1, ADIPOQ
9liver cirrhosis30.7RBP4, HFE, ADIPOQ, GGT1, SLC17A5, LEP
10hepatocellular carcinoma30.7HFE, RBP4, GPT, RGN, GGT1, SLC17A5
11morbid obesity30.7LEP, RETN, ADIPOQ
12acute liver failure30.6GPT, SLC17A5
13coronary artery disease30.6HFE, APLN, RETN, ADIPOQ
14viral hepatitis30.5SLC17A5, GPT, HFE, GGT1
15hepatitis b30.5SLC17A5, GGT1, GPT
16hellp syndrome30.4GPT, SLC17A5
17portal hypertension30.4GGT1, SLC17A5, RETN, GPT
18polycystic ovary syndrome30.4RBP4, ADIPOQ, LEP, RETN
19hemochromatosis30.4HFE
20hyperuricemia30.4GPT, GGT1
21acute pancreatitis30.3SLC17A5, GPT, RETN
22glucose intolerance30.3RETN, RBP4, GPT, ADIPOQ, LEP
23alcoholic liver cirrhosis30.3GPT, GGT1, HFE, SLC17A5
24lipodystrophy30.3ADIPOQ, LEP, RETN
25cholestasis30.1GGT1, RBP4, GPT, SLC17A5
26hepatitis e30.1GPT
27celiac disease30.1HFE
28familial hyperlipidemia30.0MTTP, RETN, GPT, LEP, GGT1, ADIPOQ
29hypothyroidism30.0ADIPOQ, LEP, RETN
30pancreatitis30.0SLC17A5, GGT1
31hyperglycemia30.0RETN, LEP, ADIPOQ
32cholelithiasis30.0GGT1, GPT
33primary biliary cirrhosis30.0GGT1, SLC17A5, GPT
34alcohol dependence30.0GGT1
35ischemia30.0SLC17A5
36pre-eclampsia29.9ADIPOQ, SLC17A5, RETN, LEP
37hypogonadism29.9ADIPOQ, LEP, HFE
38protein-energy malnutrition29.9RBP4, LEP
39thrombocytopenia29.9GPT, SLC17A5, HFE
40porphyria cutanea tarda29.9HFE
41porphyria29.9HFE
42liver disease11.5
43peroxisomal disease10.6
44hepatitis a10.5
45glucose metabolism disease10.4
46acute fatty liver of pregnancy10.4
47polycystic liver disease10.4
48disseminated intravascular coagulation10.3
49essential hypertension10.3
50kidney disease10.3

Graphical network of the top 20 diseases related to Fatty Liver Disease:



Diseases related to fatty liver disease

Clinical Features for Fatty Liver Disease

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Drugs & Therapeutics for Fatty Liver Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Fatty Liver Disease

Drug clinical trials:

Search ClinicalTrials for Fatty Liver Disease

Search NIH Clinical Center for Fatty Liver Disease

Search CenterWatch for Fatty Liver Disease

Genetic Tests for Fatty Liver Disease

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Anatomical Context for Fatty Liver Disease

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32MalaCards
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MalaCards organs/tissues related to Fatty Liver Disease:

32
Liver, Kidney, Testes, Endothelial, Adipocyte, Heart, Thyroid, Ovary, Skeletal muscle, Bone, Pancreas, Whole blood, Brain, Placenta, Prostate

Animal Models for Fatty Liver Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Fatty Liver Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.9HFE, PNPLA3, RGN, LEP, FGF21, RETN
2MP:000537811.6GGT1, SLC17A5, RGN, LEP, FGF21, HFE
3MP:000537011.2ADIPOQ, LEP, MTTP, HFE, RETN, FGF21
4MP:000537510.9ADIPOQ, RGN, LEP, FGF21, RETN, AGRP

Publications for Fatty Liver Disease

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50PubMed
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Articles related to Fatty Liver Disease:

(show top 50)    (show all 1066)
idTitleAuthorsYear
1
Carotid intima media thickness and echocardiography in risk stratification of obese adolescents with non-alcoholic fatty liver disease: what is the "right" approach? (23843575)
2014
2
The interactions of nonalcoholic fatty liver disease and cardiovascular diseases. (24274877)
2014
3
Clinical and metabolic factors associated with development and regression of nonalcoholic fatty liver disease in nonobese subjects. (24382309)
2014
4
Limited value of plasma cytokeratin-18 as a biomarker for NASH and fibrosis in patients with non-alcoholic fatty liver disease. (23973932)
2014
5
miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. (22902550)
2013
6
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease. (23213074)
2013
7
Testosterone Replacement Ameliorates Non-Alcoholic Fatty Liver Disease in Castrated Rats. (24280056)
2013
8
Dietary anthocyanins as nutritional therapy for nonalcoholic fatty liver disease. (24282628)
2013
9
Increased whole blood viscosity is associated with arterial stiffness in patients with non-alcoholic fatty liver disease. (23981121)
2013
10
Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver disease. (23862644)
2013
11
Coffee and Non-Alcoholic Fatty Liver Disease: Brewing evidence for hepatoprotection? (24199670)
2013
12
Assessment of the relationship between non-alcoholic fatty liver disease and CAD using MSCT. (24263777)
2013
13
The Effect of a Low Fructose and Low Glycemic Index/Load (FRAGILE) Dietary Intervention on Indices of Liver Function, Cardiometabolic Risk Factors, and Body Composition in Children and Adolescents With Nonalcoholic Fatty Liver Disease (NAFLD). (23976771)
2013
14
Novel therapeutic targets for nonalcoholic fatty liver disease. (23600493)
2013
15
The association between serum ferritin level, microalbuminuria and non-alcoholic fatty liver disease in non-diabetic, non-hypertensive men. (24047280)
2013
16
Pathogenesis of hepatic steatosis: the link between hypercortisolism and non-alcoholic fatty liver disease. (24187449)
2013
17
Statins for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. (24374462)
2013
18
Hepatocarcinogenesis in non-alcoholic fatty liver disease in Japan. (24251711)
2013
19
Favorable effect of modest alcohol consumption to fatty liver disease. (23983447)
2013
20
Nonalcoholic fatty liver disease and microvascular complications in type 2 diabetes. (23716995)
2013
21
Adipocyte-fatty acid binding protein and non-alcoholic fatty liver disease in the elderly. (24150574)
2013
22
Liver glycerol permeability and aquaporin-9 are dysregulated in a murine model of non-alcoholic Fatty liver disease. (24205128)
2013
23
Two genetic variants in FABP1 and susceptibility to non-alcohol fatty liver disease in a Chinese population. (22465531)
2012
24
Cardiovascular phenotype of nonalcoholic fatty liver disease: hanging the paradigm about the role of distant toxic fat accumulation on vascular disease. (22505369)
2012
25
Markedly lower follow-up rate after liver biopsy in patients with non-alcoholic fatty liver diseases than those with viral hepatitis in Japan. (21906297)
2011
26
Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease. (20176643)
2010
27
Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease. (19946731)
2010
28
Efficacy and safety of ezetimibe/simvastatin combination therapy in patients with type 2 diabetes and nonalcoholic fatty liver disease]. (19443308)
2009
29
Genetic polymorphisms in non-alcoholic fatty liver disease: interleukin-6-174G/C polymorphism is associated with non-alcoholic steatohepatitis. (19403348)
2009
30
A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity. (19738004)
2009
31
Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: association with insulin resistance. (19474742)
2009
32
Differential expression of lumican and fatty acid binding protein-1: new insights into the histologic spectrum of nonalcoholic fatty liver disease. (19330863)
2009
33
Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD). (18588668)
2008
34
Role of nonalcoholic fatty liver disease in the development of insulin resistance and diabetes. (19072347)
2008
35
Nonalcoholic fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets. (18072723)
2008
36
Expression and action of hepatic sterol regulatory element-binding protein-1c in patients with nonalcoholic fatty liver disease]. (19032865)
2008
37
Association of abnormality of liver enzymes and metabolic syndrome in patients with nonalcoholic fatty liver disease]. (17425870)
2007
38
Predictors reflecting the pathological severity of non-alcoholic fatty liver disease: comprehensive study of clinical and immunohistochemical findings in younger Asian patients. (17376039)
2007
39
Risk for nonalcoholic fatty liver disease in Hispanic youth with BMI > or =95th percentile. (17255837)
2007
40
Plasma levels of interleukin-6 and interleukin-8 in Chinese patients with non-alcoholic fatty liver disease. (18251157)
2007
41
A clinical and pathological study of nonalcoholic fatty liver disease]. (16792871)
2006
42
Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study. (16595594)
2006
43
Nonalcoholic fatty liver disease and HIV infection. (16970837)
2006
44
Urinary liver-type fatty acid binding protein as a useful biomarker in chronic kidney disease. (16532260)
2006
45
The relationship between apolipoprotein E polymorphism, lipoprotein (a) and fatty liver disease. (16334787)
2005
46
Prevalence of HFE mutations and relation to serum iron status in patients with chronic hepatitis C and patients with nonalcoholic fatty liver disease in Taiwan. (15991291)
2005
47
Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease. (15382116)
2004
48
A randomized double-blind study of the short-time treatment of obese patients with nonalcoholic fatty liver disease with ursodeoxycholic acid. (12792701)
2003
49
Nonalcoholic fatty liver disease: relationship to insulin sensitivity and oxidative stress. Treatment approaches using vitamin E, magnesium, and betaine. (12197781)
2002
50
Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease. A case-control study. (11990393)
2002

Genetic Variations for Fatty Liver Disease

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Expression for genes affiliated with Fatty Liver Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fatty Liver Disease

Search GEO for disease gene expression data for Fatty Liver Disease.

Pathways for genes affiliated with Fatty Liver Disease

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Sources:
37NCBI BioSystems Database, 52R&D Systems, 29KEGG
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Pathways related to Fatty Liver Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9ADIPOQ, PNPLA3, LEP, RETN
2
Hide members
10.9RBP4, RETN, LEP, ADIPOQ
310.8ADIPOQ, LEP, AGRP

Compounds for genes affiliated with Fatty Liver Disease

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Fatty Liver Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1glucose4412.4PNPLA3, FGF21, RETN, HFE, AGRP, MTTP
2cholesterol44 28 11 2415.3SLC17A5, GGT1, PNPLA3, ADIPOQ, LEP, GPT
3lipid4412.3ADIPOQ, GGT1, SLC17A5, GPT, FGF19, RETN
4alanine4412.0ADIPOQ, APLN, RBP4, RETN, GGT1, SLC17A5
5nash4411.8ADIPOQ, LEP, RETN, HFE, MTTP, GPT
6fatty acid4411.8ADIPOQ, SLC17A5, LEP, AGRP, RBP4, MTTP
7testosterone44 59 11 2414.8ADIPOQ, RBP4, HFE, CYP3A, RETN, LEP
8pioglitazone44 49 28 1114.7SLC17A5, ADIPOQ, GGT1, LEP, GPT, RETN
9thyroxine44 2412.7ADIPOQ, RBP4, RETN, GPT, SLC17A5, GGT1
10vitamin a44 11 2413.7GGT1, ADIPOQ, RBP4, RETN, LEP, GPT
11ascorbic acid44 2412.7ADIPOQ, SLC17A5, RGN, LEP, HFE, RBP4
12creatinine4411.6RBP4, RETN, GPT, SLC17A5, LEP, GGT1
13aspartate4411.6GPT, RETN, ADIPOQ, GGT1, HFE, RBP4
14metformin44 49 1113.6ADIPOQ, GGT1, SLC17A5, LEP, GPT, RETN
15p0024411.6RETN, RBP4, GPT, LEP, MTTP, ADIPOQ
16rosiglitazone44 49 28 11 2415.6GPT, RBP4, LEP, SLC17A5, ADIPOQ, RETN
17cocaine44 1112.6AGRP, ADIPOQ, GGT1, SLC17A5, LEP, GPT
18fenofibrate44 49 1113.5RETN, LEP, GPT, ADIPOQ, SLC17A5
19triacylglycerol4411.4ADIPOQ, PNPLA3, LEP, MTTP, RBP4
20vitamin-e4411.4GGT1, SLC17A5, GPT, MTTP, RBP4
21atorvastatin44 49 28 11 2415.4GPT, RETN, SLC17A5, MTTP, ADIPOQ
22urea44 11 2413.4SLC17A5, RBP4, GPT, RETN, GGT1
23simvastatin44 49 59 28 11 2416.4MTTP, ADIPOQ, SLC17A5, GPT, RBP4
24tacrolimus44 49 1113.4CYP3A, GPT, SLC17A5, GGT1, ADIPOQ
25methotrexate44 49 1113.3SLC17A5, GPT, LEP, ADIPOQ, GGT1
26ezetimibe44 1112.3MTTP, GPT, SLC17A5, ADIPOQ
27lamivudine44 1112.3SLC17A5, LEP, GPT, ADIPOQ
28bezafibrate44 28 1113.3GPT, GGT1, ADIPOQ, SLC17A5
29phosphorus4411.3GPT, RBP4, SLC17A5, GGT1
30ribavirin44 49 1113.3SLC17A5, GPT, LEP, GGT1
31rifampicin44 28 5913.3GGT1, CYP3A, GPT, SLC17A5
32c-peptide4411.2SLC17A5, ADIPOQ, LEP, RETN
33betacarotene4411.2SLC17A5, LEP, RBP4, GGT1
34phenobarbital44 28 1113.2GGT1, CYP2A, SLC17A5, GPT
35clozapine44 28 49 1114.2LEP, GGT1, ADIPOQ, GPT
36ethanol44 49 11 2414.2SLC17A5, MTTP, HFE, GPT, GGT1
37aminopyrine4411.2GPT, SLC17A5, GGT1
38stavudine44 1112.1LEP, ADIPOQ, GPT
39fibrinogen4411.1ADIPOQ, SLC17A5, RETN, GPT, LEP
40nevirapine44 49 1113.1GGT1, GPT, SLC17A5
41sevoflurane44 1112.1GGT1, GPT, SLC17A5
42uric acid44 2412.0HFE
43oxyntomodulin44 5912.0AGRP, LEP, ADIPOQ
44heparin44 28 11 2414.0ADIPOQ, FGF19, PNPLA3
45troglitazone44 28 59 1113.9GPT, ADIPOQ, SLC17A5, LEP
46verapamil44 49 28 11 2414.9SLC17A5, GGT1, GPT, MTTP
47p0034410.9RETN, HFE
48alpha tocopherol4410.8RBP4
49phospholipid4410.7PNPLA3, ADIPOQ, RBP4, SLC17A5, MTTP
50isoflurane44 1111.7GGT1, GPT, SLC17A5

GO Terms for genes affiliated with Fatty Liver Disease

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16Gene Ontology
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Cellular components related to Fatty Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.2ADIPOQ, LEP, RETN, AGRP, RBP4, APLN
2extracellular regionGO:00557611.1ADIPOQ, APLN, RBP4, RETN, FGF19, FGF21

Biological processes related to Fatty Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of glucose importGO:04632610.8ADIPOQ, FGF21, FGF19
2adult feeding behaviorGO:00834310.7LEP, AGRP
3negative regulation of vasoconstrictionGO:04590610.6LEP, APLN
4response to insulin stimulusGO:03286810.5RBP4, RETN, LEP

Molecular functions related to Fatty Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00510210.9ADIPOQ, HFE, AGRP, APLN
2hormone activityGO:00517910.6ADIPOQ, LEP, RETN, APLN

Products for genes affiliated with Fatty Liver Disease

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  • Antibodies
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Sources for Fatty Liver Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet