MCID: FTT001
MIFTS: 43

Fatty Liver Disease malady

Gastrointestinal diseases, Liver diseases categories
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Summaries for Fatty Liver Disease

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33MalaCards
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MalaCards: Fatty Liver Disease, also known as fatty liver, is related to liver disease and acute fatty liver of pregnancy. An important gene associated with Fatty Liver Disease is PNPLA3 (patatin-like phospholipase domain containing 3), and among its related pathways is Cardiac muscle contraction. The compound phenobarbital have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and adipocyte.

Aliases & Classifications for Fatty Liver Disease

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

fatty liver disease 8 10
fatty liver 45 62
fatty liver, alcoholic 62
fatty change of liver 8
alcoholic fatty liver 8
fatty liver alcoholic 45
fatty degeneration 62
steatosis of liver 8
hepatic lipidosis 8


External Ids:

Disease Ontology8 DOID:9452
ICD9CM27 571.0
ICD1025 K70.0, K76.0

Related Diseases for Fatty Liver Disease

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Fatty Liver Disease:



Diseases related to fatty liver disease

Symptoms for Fatty Liver Disease

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Drugs & Therapeutics for Fatty Liver Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Fatty Liver Disease

Search NIH Clinical Center for Fatty Liver Disease

Genetic Tests for Fatty Liver Disease

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Anatomical Context for Fatty Liver Disease

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33MalaCards
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MalaCards organs/tissues related to Fatty Liver Disease:

33
Liver, Endothelial, Adipocyte, Heart, Kidney, Testes, Thyroid, Ovary, Bone, Skeletal muscle, Whole blood, Brain, Pancreas, Prostate

Animal Models for Fatty Liver Disease or affiliated genes

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Publications for Fatty Liver Disease

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52PubMed
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Articles related to Fatty Liver Disease:

(show top 50)    (show all 1025)
idTitleAuthorsYear
1
Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor I' activation. (23605066)
2013
2
Pediatric non-alcoholic fatty liver disease: an increasing public health issue. (24068459)
2013
3
miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. (22902550)
2013
4
Simple noninvasive systems predict long-term outcomes of patients with nonalcoholic fatty liver disease. (23860502)
2013
5
Oral probiotic microcapsule formulation ameliorates non-alcoholic fatty liver disease in Bio F1B Golden Syrian hamsters. (23554890)
2013
6
The prevalence and clinical correlates of nonalcoholic fatty liver disease (NAFLD) in African Americans: the multiethnic study of atherosclerosis (MESA). (23546700)
2013
7
Efficacy of Tumor Necrosis Factor and Interleukin-10 Analysis in the Follow-up of Nonalcoholic Fatty Liver Disease Progression. (24426199)
2013
8
Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent. (23564467)
2013
9
Abnormality of Autophagic Function and Cathepsin Expression in the Liver from Patients with Non-alcoholic fatty liver disease. (24299564)
2013
10
IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice. (24115079)
2013
11
Expression of cytochrome P450 2A5 in a C57BL/6J mouse model of nonalcoholic fatty liver disease. (23867551)
2013
12
Coffee enhances the expression of chaperones and antioxidant proteins in rats with nonalcoholic fatty liver disease. (24365744)
2013
13
Blood urea nitrogen is elevated in patients with non-alcoholic fatty liver disease. (23858556)
2013
14
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease. (23213074)
2013
15
Treatment of non-alcoholic fatty liver disease: can we already face the epidemic? (23898557)
2013
16
Pediatric non alcoholic fatty liver disease: old and new concepts on development, progression, metabolic insight and potential treatment targets. (23530957)
2013
17
Chronic kidney disease and nonalcoholic Fatty liver disease proven by transient elastography. (24029696)
2013
18
Analysis of cytotoxic T-lymphocyte-associated antigen-4 and MMP-9 genes' methylation and their expression profiles with risk of non-alcoholic fatty liver disease. (24019613)
2013
19
Non-alcoholic fatty liver disease is not associated with vitamin D deficiency in essential hypertension. (23584921)
2013
20
Nonalcoholic fatty liver disease is associated with increased GHBP and reduced GH/IGF-I levels. (22077984)
2012
21
Expression of MCP-1 in the patients of chronic hepatitis B complicated with nonalcoholic fatty liver disease]. (22980664)
2012
22
Concentrations of connective tissue growth factor in patients with nonalcoholic fatty liver disease: association with liver fibrosis. (22846210)
2012
23
Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study. (20825652)
2010
24
Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. (19523535)
2009
25
Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease. (18713296)
2009
26
The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease. (18839053)
2009
27
Prescribing statins to patients with nonalcoholic fatty liver disease: real cardiovascular benefits outweigh theoretical hepatotoxic risk. (19555426)
2009
28
Efficacy and safety of ezetimibe/simvastatin combination therapy in patients with type 2 diabetes and nonalcoholic fatty liver disease]. (19443308)
2009
29
The multi-hit process and the antagonistic roles of tumor necrosis factor-alpha and adiponectin in non alcoholic fatty liver disease. (19561788)
2009
30
Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. (19524579)
2009
31
The evolution of ideas about nonalcohol fatty liver disease]. (19967814)
2009
32
Abdominal adipose area, serum adiponectin and leptin levels of nonalcoholic fatty liver disease in elderly males.]. (19254460)
2009
33
Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome. (19765850)
2009
34
Gene expression profile associated with superimposed non-alcoholic fatty liver disease and hepatic fibrosis in patients with chronic hepatitis C. (19515216)
2009
35
A complex role of activin A in non-alcoholic fatty liver disease. (19532130)
2009
36
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. (18242210)
2008
37
Leptin in nonalcoholic fatty liver disease. (18753993)
2008
38
Peroxisome proliferator-activated receptor gamma: a common link for non-alcoholic fatty liver disease and colorectal cancer? (17482764)
2007
39
The prevalence of peripheral iron overload and the presence of HFE gene (H63D) mutation among the Korean patients with nonalcoholic fatty liver disease]. (17585191)
2007
40
Methylenetetrahydrofolate reductase C677T mutation and nonalcoholic fatty liver disease. (17356914)
2007
41
Gene expression patterns in hepatic tissue and visceral adipose tissue of patients with non-alcoholic fatty liver disease. (17953248)
2007
42
Non-invasive markers to predict the liver fibrosis in non-alcoholic fatty liver disease. (16911470)
2006
43
Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. (16618517)
2006
44
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. (16799979)
2006
45
Nonalcoholic fatty liver disease in India--is it different? (17542290)
2006
46
Association between tumor necrosis factor-alpha gene polymorphism and insulin resistance in nonalcoholic fatty liver disease]. (16938178)
2006
47
Association of serum leptin and insulin resistance with nonalcoholic fatty liver disease]. (16793619)
2006
48
The role of PPAR alpha in the pathogenesis of fatty liver disease]. (16174475)
2005
49
Management of fatty liver disease with vitamin E and C compared to ursodeoxycholic acid treatment. (16245220)
2005
50
Leptin and fatty liver disease]. (15329225)
2004

Variations for Fatty Liver Disease

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Expression for genes affiliated with Fatty Liver Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fatty Liver Disease

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Pathways for genes affiliated with Fatty Liver Disease

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50PathCards, 30KEGG
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Pathways related to Fatty Liver Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4UQCRHL, COX8C

Compounds for genes affiliated with Fatty Liver Disease

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45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank
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Compounds related to Fatty Liver Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1phenobarbital45 29 51 1112.8GPT, CYP2A

GO Terms for genes affiliated with Fatty Liver Disease

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Products for genes affiliated with Fatty Liver Disease

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  • Antibodies
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Sources for Fatty Liver Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet