MCID: FTT001
MIFTS: 58

Fatty Liver Disease malady

Gastrointestinal, Liver categories

Summaries for Fatty Liver Disease

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33MalaCards
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MalaCards: Fatty Liver Disease, also known as fatty liver, is related to insulin resistance and atherosclerosis. An important gene associated with Fatty Liver Disease is PNPLA3 (patatin-like phospholipase domain containing 3), and among its related pathways are Adipogenesis and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The compounds glucose and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and brain, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Aliases & Classifications for Fatty Liver Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Liver


Aliases & Descriptions:

fatty liver disease 8 10
fatty liver 45 61
fatty liver, alcoholic 61
alcoholic fatty liver 8
fatty change of liver 8
fatty liver alcoholic 45
fatty degeneration 61
steatosis of liver 8
hepatic lipidosis 8


External Ids:

Disease Ontology8 DOID:9452
ICD9CM27 571.0
ICD1025 K70.0, K76.0

Related Diseases for Fatty Liver Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Fatty Liver Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance31.5HFE, MTTP, RBP4, APLN, RETN, GPT
2atherosclerosis31.0APLN, RBP4, MTTP, RETN, LEP, GGT1
3hepatitis c31.0RBP4, MTTP, HFE, GPT, SLC17A5, GGT1
4alcoholic hepatitis30.8GPT, SLC17A5, GGT1
5morbid obesity30.7RETN, LEP, ADIPOQ
6coronary artery disease,30.7APLN, HFE, RETN, ADIPOQ
7acute liver failure30.7SLC17A5, GPT
8hepatitis e30.7GPT
9viral hepatitis30.5HFE, GPT, SLC17A5, GGT1
10portal hypertension30.4RETN, GPT, SLC17A5, GGT1
11polycystic ovary syndrome30.4ADIPOQ, LEP, RETN, RBP4
12hellp syndrome30.4GPT, SLC17A5
13hepatitis b30.4GPT, SLC17A5, GGT1
14hemochromatosis30.4HFE
15hyperuricemia30.4GGT1, GPT
16coronary heart disease30.3MTTP, HFE, RETN, LEP, GGT1, ADIPOQ
17glucose intolerance30.3RBP4, RETN, GPT, LEP, ADIPOQ
18alcoholic liver cirrhosis30.3HFE, GPT, SLC17A5, GGT1
19hypercholesterolemia30.3RBP4, MTTP, RETN, GPT, SLC17A5, GGT1
20acute pancreatitis30.3RETN, GPT, SLC17A5
21celiac disease30.1HFE
22type 2 diabetes mellitus30.1RBP4, MTTP, RETN, FGF21, GPT, LEP
23hypertriglyceridemia30.1ADIPOQ, GGT1, LEP, GPT, MTTP
24cholelithiasis30.1GGT1, GPT
25primary biliary cirrhosis30.1GGT1, SLC17A5, GPT
26wilson disease29.9HFE, GPT, SLC17A5
27thrombocytopenia29.9HFE, GPT, SLC17A5
28porphyria cutanea tarda29.9HFE
29nonalcoholic steatohepatitis10.9
30lip disease10.8
31n syndrome10.8
32hepatitis d10.7
33hepatitis a10.6
34nutrition disease10.5
35cardiovascular disease risk factor10.5
36acute fatty liver of pregnancy10.5
37polycystic liver disease10.4
38hepatitis c virus10.4
39vascular disease10.4
40sleep apnea10.4
41fatty liver disease, nonalcoholic 110.4
42hypobetalipoproteinemia10.3
43fatty liver disease, nonalcoholic 210.3
44familial mediterranean fever10.2
45duchenne muscular dystrophy10.2
46adenoma10.2
47thrombophilia10.2
48colorectal cancer10.2
49pnpla3-related susceptibility to nonalchoholic fatty liver disease10.2
50hypoxia10.2

Graphical network of the top 20 diseases related to Fatty Liver Disease:



Diseases related to fatty liver disease

Clinical Features for Fatty Liver Disease

Drugs & Therapeutics for Fatty Liver Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Fatty Liver Disease

Drug clinical trials:

Search ClinicalTrials for Fatty Liver Disease

Search NIH Clinical Center for Fatty Liver Disease

Search CenterWatch for Fatty Liver Disease

Genetic Tests for Fatty Liver Disease

Anatomical Context for Fatty Liver Disease

Sources:
33MalaCards
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MalaCards organs/tissues related to Fatty Liver Disease:

33
Ovary, Liver, Brain, Kidney, Whole blood, Heart, Skeletal muscle, Small intestine, Adipocyte, Pancreas, Thyroid, Placenta, Prostate, T cells, B cells, Endothelial, Fetal brain, Fetal liver, Fetal thyroid, Pancreatic islet

Animal Models for Fatty Liver Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Fatty Liver Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.9ADIPOQ, APLN, RBP4, MTTP, AGRP, HFE
2MP:000537811.6MTTP, AGRP, HFE, FGF21, LEP, RGN
3MP:000537011.2MTTP, HFE, RETN, FGF21, LEP, RGN
4MP:000537510.9AGRP, RETN, FGF21, LEP, RGN, ADIPOQ

Publications for Fatty Liver Disease

Sources:
51PubMed
See all sources

Articles related to Fatty Liver Disease:

(show top 50)    (show all 1068)
idTitleAuthorsYear
1
Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease. (24419221)
2014
2
Statin use is not associated with presence of and severity of nonalcoholic Fatty liver disease. (24333254)
2014
3
Free radical biology for medicine: learning from nonalcoholic fatty liver disease. (23994574)
2013
4
Association between nonalcoholic fatty liver disease and the incidence of cardiovascular and renal events. (24198448)
2013
5
Patients with non-alcoholic fatty liver disease (NAFLD) have an increased risk of atherosclerosis and cardiovascular disease. (24377153)
2013
6
Review article: coffee consumption, the metabolic syndrome and non-alcoholic fatty liver disease. (24024834)
2013
7
Independent associations of low 25 hydroxy vitamin D and high parathyroid hormonal levels with nonalcoholic fatty liver disease in Asian Indians residing in north India. (23958268)
2013
8
Relationship between hepatocellular carcinoma, metabolic syndrome and non-alcoholic fatty liver disease: which clinical arguments? (23597944)
2013
9
Body composition and body fat distribution are related to cardiac autonomic control in non-alcoholic fatty liver disease patients. (24300906)
2013
10
A Study of Carotid Atherosclerosis in Patients with Non-alcoholic Fatty Liver Disease. (24381427)
2013
11
Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice. (23560443)
2013
12
Clinicopathological characteristics and metabolic profiles of non-alcoholic fatty liver disease in Indian patients with normal body mass index: Do they differ from obese or overweight non-alcoholic fatty liver disease? (23961483)
2013
13
Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: design and rationale of randomized controlled trial. (23702094)
2013
14
Functional impairment in alcoholic liver disease and non-alcoholic fatty liver disease is significant and persists over 3 years of follow-up. (23609794)
2013
15
Characterization of Hepatocellular Carcinoma Related Genes and Metabolites in Human Nonalcoholic Fatty Liver Disease. (24048683)
2013
16
Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients. (24277052)
2013
17
Rosiglitazone and bezafibrate modulate gene expression in a rat model of non-alcoholic fatty liver disease--a historical prospective. (23531105)
2013
18
Association of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease. (23633195)
2013
19
Nonalcoholic steatohepatitis in nonalcoholic fatty liver disease patients of Bangladesh. (23717739)
2013
20
Nonalcoholic fatty liver disease in severely obese adolescent and adult patients. (23592668)
2013
21
Dynamics of oxidative/nitrosative stress in mice with methionine-choline-deficient diet-induced nonalcoholic fatty liver disease. (24130212)
2013
22
Multi-SNP analysis of GWAS data identifies pathways associated with nonalcoholic fatty liver disease. (23894275)
2013
23
Zerumbone, a Natural Cyclic Sesquiterpene of Zingiber zerumbet Smith, Attenuates Nonalcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet. (24223615)
2013
24
The effect of helicobacter pylori eradication on liver fat content in subjects with non-alcoholic Fatty liver disease: a randomized open-label clinical trial. (24358044)
2013
25
Does PPARI^2 gene Pro12Ala polymorphism affect nonalcoholic fatty liver disease risk? Evidence from a meta-analysis. (23448101)
2013
26
Adipokines and C-reactive protein in relation to bone mineralization in pediatric nonalcoholic fatty liver disease. (23840146)
2013
27
Expression of MCP-1 in the patients of chronic hepatitis B complicated with nonalcoholic fatty liver disease]. (22980664)
2012
28
Real-time tissue elastography for evaluation of hepatic fibrosis and portal hypertension in nonalcoholic fatty liver diseases. (22488593)
2012
29
Decreased immunoexpression of survivin could be a potential marker in human non-alcoholic fatty liver disease progression? (21108736)
2011
30
Serum FGF21 levels are increased in newly diagnosed type 2 diabetes with nonalcoholic fatty liver disease and associated with hsCRP levels independently. (21596453)
2011
31
Serum fetuin A/I+2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: relation with liver fibrosis. (20926473)
2010
32
Involvement and mechanism of DGAT2 upregulation in the pathogenesis of alcoholic fatty liver disease. (20739640)
2010
33
Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. (20675007)
2010
34
Influence of genipin and vitamin E on UCP2 and other correlation factors in non-alcoholic fatty liver disease]. (21374988)
2010
35
Alcoholic fatty liver disease and alcoholic liver cirrhosis may be differentiated with mean platelet volume and platelet distribution width. (20672909)
2010
36
Losartan reduces liver expression of plasminogen activator inhibitor-1 (PAI-1) in a high fat-induced rat nonalcoholic fatty liver disease model. (19230890)
2009
37
Current status of liver disease in Korea: nonalcoholic fatty liver disease. (20037278)
2009
38
Prevalence of and risk factors for fatty liver disease in a professional population of Wuhan, China. (19674763)
2009
39
Variants in the UGT1A1 gene and the risk of pediatric nonalcoholic fatty liver disease. (19948621)
2009
40
Leptin in nonalcoholic fatty liver disease. (18753993)
2008
41
The significance of resistin expression in livers of patients with nonalcoholic fatty liver disease]. (18752757)
2008
42
A Val227Ala substitution in the peroxisome proliferator activated receptor alpha (PPAR alpha) gene associated with non-alcoholic fatty liver disease and decreased waist circumference and waist-to-hip ratio. (18853997)
2008
43
Hepatic cytochrome P450 2E1 activity in nonalcoholic fatty liver disease. (18672640)
2008
44
Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss. (18728159)
2008
45
Peroxisome proliferator-activated receptor gamma: a common link for non-alcoholic fatty liver disease and colorectal cancer? (17482764)
2007
46
Post-load insulin resistance is an independent predictor of hepatic fibrosis in virus C chronic hepatitis and in non-alcoholic fatty liver disease. (17392334)
2007
47
Association between tumor necrosis factor-alpha gene polymorphism and insulin resistance in nonalcoholic fatty liver disease]. (16938178)
2006
48
Nonalcoholic fatty liver disease: from steatosis to cirrhosis. (16447287)
2006
49
Statins for non-alcoholic fatty liver disease: a new indication? (16907904)
2006
50
Acute fatty liver of pregnancy and the microvesicular fat diseases. (6832621)
1983

Genetic Variations for Fatty Liver Disease

Expression for genes affiliated with Fatty Liver Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Fatty Liver Disease

Search GEO for disease gene expression data for Fatty Liver Disease.

Pathways for genes affiliated with Fatty Liver Disease

Sources:
38NCBI BioSystems Database, 53R&D Systems, 30KEGG
See all sources

Pathways related to Fatty Liver Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9ADIPOQ, PNPLA3, LEP, RETN
2
Hide members
10.9RBP4, RETN, LEP, ADIPOQ
310.8ADIPOQ, LEP, AGRP

Compounds for genes affiliated with Fatty Liver Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB
See all sources

Compounds related to Fatty Liver Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1glucose4512.4HFE, AGRP, MTTP, RBP4, APLN, RETN
2cholesterol45 29 11 2415.3RETN, HFE, MTTP, RBP4, APLN, FGF19
3lipid4512.3RBP4, MTTP, HFE, RETN, FGF19, FGF21
4alanine4512.0APLN, RBP4, MTTP, HFE, RETN, GPT
5nash4511.8ADIPOQ, MTTP, HFE, RETN, GPT, LEP
6fatty acid4511.8RBP4, MTTP, AGRP, RETN, LEP, PNPLA3
7testosterone45 60 11 2414.8RBP4, HFE, CYP3A, RETN, LEP, SLC17A5
8pioglitazone45 50 29 1114.7RBP4, RETN, GPT, LEP, SLC17A5, GGT1
9thyroxine45 2412.7RBP4, RETN, GPT, LEP, SLC17A5, GGT1
10vitamin a45 11 2413.7RBP4, RETN, GPT, LEP, SLC17A5, GGT1
11ascorbic acid45 2412.7RBP4, HFE, LEP, RGN, SLC17A5, GGT1
12creatinine4511.6RBP4, RETN, GPT, LEP, SLC17A5, GGT1
13aspartate4511.6RBP4, HFE, RETN, GPT, SLC17A5, GGT1
14metformin45 50 1113.6RETN, GPT, LEP, SLC17A5, GGT1, ADIPOQ
15p0024511.6RBP4, MTTP, RETN, GPT, LEP, ADIPOQ
16rosiglitazone45 50 29 11 2415.6RBP4, RETN, GPT, LEP, SLC17A5, ADIPOQ
17cocaine45 1112.6AGRP, GPT, LEP, SLC17A5, GGT1, ADIPOQ
18fenofibrate45 50 1113.5RETN, GPT, LEP, SLC17A5, ADIPOQ
19triacylglycerol4511.4RBP4, MTTP, LEP, PNPLA3, ADIPOQ
20vitamin-e4511.4RBP4, MTTP, GPT, SLC17A5, GGT1
21atorvastatin45 50 29 11 2415.4MTTP, RETN, GPT, SLC17A5, ADIPOQ
22urea45 11 2413.4RBP4, RETN, GPT, SLC17A5, GGT1
23simvastatin45 50 60 29 11 2416.4RBP4, MTTP, GPT, SLC17A5, ADIPOQ
24tacrolimus45 50 1113.4CYP3A, GPT, SLC17A5, GGT1, ADIPOQ
25methotrexate45 50 1113.3GPT, LEP, SLC17A5, GGT1, ADIPOQ
26ezetimibe45 1112.3ADIPOQ, SLC17A5, GPT, MTTP
27lamivudine45 1112.3GPT, LEP, SLC17A5, ADIPOQ
28bezafibrate45 29 1113.3GPT, SLC17A5, GGT1, ADIPOQ
29phosphorus4511.3GGT1, SLC17A5, GPT, RBP4
30ribavirin45 50 1113.3GGT1, SLC17A5, LEP, GPT
31rifampicin45 29 6013.3CYP3A, GPT, SLC17A5, GGT1
32c-peptide4511.2RETN, LEP, SLC17A5, ADIPOQ
33betacarotene4511.2GGT1, SLC17A5, LEP, RBP4
34phenobarbital45 29 1113.2GGT1, SLC17A5, GPT, CYP2A
35clozapine45 29 50 1114.2ADIPOQ, GGT1, LEP, GPT
36ethanol45 50 11 2414.2GGT1, SLC17A5, GPT, HFE, MTTP
37aminopyrine4511.2GGT1, SLC17A5, GPT
38stavudine45 1112.1ADIPOQ, LEP, GPT
39fibrinogen4511.1RETN, GPT, LEP, SLC17A5, ADIPOQ
40nevirapine45 50 1113.1GPT, SLC17A5, GGT1
41sevoflurane45 1112.1GPT, SLC17A5, GGT1
42uric acid45 2412.0HFE
43oxyntomodulin45 6012.0AGRP, LEP, ADIPOQ
44heparin45 29 11 2414.0ADIPOQ, PNPLA3, FGF19
45troglitazone45 29 60 1113.9ADIPOQ, SLC17A5, LEP, GPT
46verapamil45 50 29 11 2414.9MTTP, GPT, SLC17A5, GGT1
47p0034510.9HFE, RETN
48alpha tocopherol4510.8RBP4
49phospholipid4510.7RBP4, MTTP, PNPLA3, SLC17A5, ADIPOQ
50isoflurane45 1111.7GGT1, SLC17A5, GPT

GO Terms for genes affiliated with Fatty Liver Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Fatty Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.2ADIPOQ, LEP, RETN, AGRP, RBP4, APLN
2extracellular regionGO:00557611.1ADIPOQ, APLN, RBP4, RETN, FGF19, FGF21

Biological processes related to Fatty Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of glucose importGO:04632610.8ADIPOQ, FGF21, FGF19
2adult feeding behaviorGO:00834310.7LEP, AGRP
3negative regulation of vasoconstrictionGO:04590610.6LEP, APLN
4response to insulin stimulusGO:03286810.5RBP4, RETN, LEP

Molecular functions related to Fatty Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00510210.9ADIPOQ, HFE, AGRP, APLN
2hormone activityGO:00517910.6ADIPOQ, LEP, RETN, APLN

Products for genes affiliated with Fatty Liver Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fatty Liver Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet