MCID: FTT001
MIFTS: 39

Fatty Liver Disease malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Fatty Liver Disease

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Disease Ontology:9 A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in liver cells via the process of steatosis.

MalaCards based summary: Fatty Liver Disease, also known as fatty liver, is related to liver disease and obesity. An important gene associated with Fatty Liver Disease is PNPLA3 (patatin-like phospholipase domain containing 3), and among its related pathways is Cardiac muscle contraction. The compound phenobarbital have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and adipocyte.

Wikipedia:63 Fatty liver, also known as fatty liver disease (FLD), is a reversible condition wherein large vacuoles... more...

Aliases & Classifications for Fatty Liver Disease

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Sources:
9Disease Ontology, 11DISEASES, 60UMLS, 43Novoseek, 33MeSH, 55SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Fatty Liver Disease, Aliases & Descriptions:

Name: Fatty Liver Disease 9 11
Fatty Liver 43 60
Fatty Metamorphosis of Viscera 60
Fatty Liver, Alcoholic 60
Fatty Liver Alcoholic 43
 
Alcoholic Fatty Liver 9
Fatty Change of Liver 9
Steatosis of Liver 9
Hepatic Lipidosis 9
Steatohepatitis 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


External Ids:

Disease Ontology9 DOID:9452
ICD9CM27 571.0
ICD1025 K70.0, K76.0

Related Diseases for Fatty Liver Disease

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Graphical network of the top 20 diseases related to Fatty Liver Disease:



Diseases related to fatty liver disease

Symptoms for Fatty Liver Disease

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Drugs & Therapeutics for Fatty Liver Disease

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Drug clinical trials:

Search ClinicalTrials for Fatty Liver Disease

Search NIH Clinical Center for Fatty Liver Disease

Genetic Tests for Fatty Liver Disease

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Anatomical Context for Fatty Liver Disease

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MalaCards organs/tissues related to Fatty Liver Disease:

31
Liver, Heart, Adipocyte, Endothelial, Kidney, Ovary, Testes, Thyroid, Bone, Skeletal muscle, Whole blood, Brain, Pancreas, Prostate

Animal Models for Fatty Liver Disease or affiliated genes

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Publications for Fatty Liver Disease

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Articles related to Fatty Liver Disease:

(show top 50)    (show all 1082)
idTitleAuthorsYear
1
Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice. (25891086)
2015
2
Nonalcoholic Fatty Liver Disease and Hyperuricemia: A Close Relation with Hepatic Insulin Resistance after Nicotinic Acid Treatment? (25350520)
2014
3
Acceleration training for managing nonalcoholic fatty liver disease: a pilot study. (25404857)
2014
4
Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease. (25386055)
2014
5
Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor I' activation. (23605066)
2013
6
Pediatric non-alcoholic fatty liver disease: an increasing public health issue. (24068459)
2013
7
miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. (22902550)
2013
8
Simple noninvasive systems predict long-term outcomes of patients with nonalcoholic fatty liver disease. (23860502)
2013
9
Oral probiotic microcapsule formulation ameliorates non-alcoholic fatty liver disease in Bio F1B Golden Syrian hamsters. (23554890)
2013
10
The prevalence and clinical correlates of nonalcoholic fatty liver disease (NAFLD) in African Americans: the multiethnic study of atherosclerosis (MESA). (23546700)
2013
11
Efficacy of Tumor Necrosis Factor and Interleukin-10 Analysis in the Follow-up of Nonalcoholic Fatty Liver Disease Progression. (24426199)
2013
12
Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent. (23564467)
2013
13
Abnormality of Autophagic Function and Cathepsin Expression in the Liver from Patients with Non-alcoholic fatty liver disease. (24299564)
2013
14
IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice. (24115079)
2013
15
Expression of cytochrome P450 2A5 in a C57BL/6J mouse model of nonalcoholic fatty liver disease. (23867551)
2013
16
Coffee enhances the expression of chaperones and antioxidant proteins in rats with nonalcoholic fatty liver disease. (24365744)
2013
17
Blood urea nitrogen is elevated in patients with non-alcoholic fatty liver disease. (23858556)
2013
18
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease. (23213074)
2013
19
Treatment of non-alcoholic fatty liver disease: can we already face the epidemic? (23898557)
2013
20
Pediatric non alcoholic fatty liver disease: old and new concepts on development, progression, metabolic insight and potential treatment targets. (23530957)
2013
21
Chronic kidney disease and nonalcoholic Fatty liver disease proven by transient elastography. (24029696)
2013
22
Analysis of cytotoxic T-lymphocyte-associated antigen-4 and MMP-9 genes' methylation and their expression profiles with risk of non-alcoholic fatty liver disease. (24019613)
2013
23
Nonalcoholic fatty liver disease is associated with increased GHBP and reduced GH/IGF-I levels. (22077984)
2012
24
Expression of MCP-1 in the patients of chronic hepatitis B complicated with nonalcoholic fatty liver disease]. (22980664)
2012
25
Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study. (20825652)
2010
26
Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. (19523535)
2009
27
Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease. (18713296)
2009
28
The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease. (18839053)
2009
29
Prescribing statins to patients with nonalcoholic fatty liver disease: real cardiovascular benefits outweigh theoretical hepatotoxic risk. (19555426)
2009
30
Efficacy and safety of ezetimibe/simvastatin combination therapy in patients with type 2 diabetes and nonalcoholic fatty liver disease]. (19443308)
2009
31
The multi-hit process and the antagonistic roles of tumor necrosis factor-alpha and adiponectin in non alcoholic fatty liver disease. (19561788)
2009
32
Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. (19524579)
2009
33
The evolution of ideas about nonalcohol fatty liver disease]. (19967814)
2009
34
Abdominal adipose area, serum adiponectin and leptin levels of nonalcoholic fatty liver disease in elderly males.]. (19254460)
2009
35
Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome. (19765850)
2009
36
Gene expression profile associated with superimposed non-alcoholic fatty liver disease and hepatic fibrosis in patients with chronic hepatitis C. (19515216)
2009
37
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. (18242210)
2008
38
Peroxisome proliferator-activated receptor gamma: a common link for non-alcoholic fatty liver disease and colorectal cancer? (17482764)
2007
39
The prevalence of peripheral iron overload and the presence of HFE gene (H63D) mutation among the Korean patients with nonalcoholic fatty liver disease]. (17585191)
2007
40
Methylenetetrahydrofolate reductase C677T mutation and nonalcoholic fatty liver disease. (17356914)
2007
41
Gene expression patterns in hepatic tissue and visceral adipose tissue of patients with non-alcoholic fatty liver disease. (17953248)
2007
42
Non-invasive markers to predict the liver fibrosis in non-alcoholic fatty liver disease. (16911470)
2006
43
Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. (16618517)
2006
44
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. (16799979)
2006
45
Nonalcoholic fatty liver disease in India--is it different? (17542290)
2006
46
Association between tumor necrosis factor-alpha gene polymorphism and insulin resistance in nonalcoholic fatty liver disease]. (16938178)
2006
47
Association of serum leptin and insulin resistance with nonalcoholic fatty liver disease]. (16793619)
2006
48
The role of PPAR alpha in the pathogenesis of fatty liver disease]. (16174475)
2005
49
Management of fatty liver disease with vitamin E and C compared to ursodeoxycholic acid treatment. (16245220)
2005
50
Leptin and fatty liver disease]. (15329225)
2004

Variations for Fatty Liver Disease

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Expression for genes affiliated with Fatty Liver Disease

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Search GEO for disease gene expression data for Fatty Liver Disease.

Pathways for genes affiliated with Fatty Liver Disease

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Pathways related to Fatty Liver Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4UQCRHL, COX8C

Compounds for genes affiliated with Fatty Liver Disease

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Sources:
43Novoseek, 28IUPHAR, 49PharmGKB, 12DrugBank
See all sources

Compounds related to Fatty Liver Disease according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1phenobarbital43 28 49 1212.8GPT, CYP2A

GO Terms for genes affiliated with Fatty Liver Disease

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Products for genes affiliated with Fatty Liver Disease

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  • Antibodies
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  • Proteins
  • Kits and Assays

Sources for Fatty Liver Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet