MCID: FVS001
MIFTS: 46

Favism malady

Summaries for Favism

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans.

MalaCards: Favism is related to glucosephosphate dehydrogenase deficiency and hemolytic anemia. An important gene associated with Favism is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are FoxO family signaling and Folate Metabolism. The compounds 23-diphosphoglycerate and nadph have been mentioned in the context of this disorder. Affiliated tissues include kidney, breast and liver, and related mouse phenotype tumorigenesis.

Wikipedia:63 Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is an X-linked recessive hereditary... more...

Description from OMIM:46 134700

Aliases & Classifications for Favism

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8Disease Ontology, 9diseasecard, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

favism 8 9 22 46 10 44 60


External Ids:

Disease Ontology8 DOID:13628
MeSH34 D005236
NCIt39 C34607

Related Diseases for Favism

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17GeneCards, 18GeneDecks
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Diseases related to Favism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1glucosephosphate dehydrogenase deficiency30.3G6PD, HP
2hemolytic anemia30.3HP, G6PD
3deficiency anemia30.1HP, HBA1, G6PD
4methemoglobinemia29.9HP, G6PD
5malaria29.9ACP1, HP, G6PD
6thalassemia10.2
7neonatal jaundice10.0G6PD
8blackwater fever10.0G6PD
9liver cirrhosis10.0HP
10obesity10.0ACP1
11viral hepatitis10.0G6PD
12polycythemia10.0G6PD
13microcytic anemia10.0G6PD
14leishmaniasis10.0ACP1
15iron deficiency anemia10.0G6PD
16nephrotic syndrome10.0HP
17hyperuricemia10.0G6PC
18sickle cell anemia10.0G6PD, HP
19congenital hemolytic anemia10.0G6PD, HP
20hemoglobinopathy10.0HP, G6PD
21paroxysmal nocturnal hemoglobinuria10.0HP, G6PD
22congenital hypothyroidism10.0G6PD
23sickle cell disease10.0HP, G6PD
24bilirubin metabolic disorder10.0HP, G6PD
25cerebral malaria10.0HP, G6PD
26meningitis10.0CAT
27beta thalassemia10.0
28plasmodium falciparum malaria10.0G6PD, HP
29keshan disease10.0GPX8, GPX6
30diabetic cataract10.0G6PD, CAT
31senile cataract10.0G6PD, CAT
32chronic granulomatous disease10.0G6PD, CAT
33hepatocellular carcinoma10.0ACP1, G6PC
34glioblastoma multiforme10.0ACP1, G6PC
35respiratory failure10.0G6PD, CAT
36alpha thalassemia10.0HBA1, G6PD
37insulin resistance10.0ACP1, G6PC
38acute kidney failure10.0CAT, G6PD, HP
39autoimmune hemolytic anemia10.0HP, G6PD
40pulmonary tuberculosis10.0ACP1, HP, CAT
41vascular disease10.0CAT, G6PD, HP
42hypertrophy of breast10.0ACP1, HP, G6PD
43metabolic syndrome x10.0ACP1, G6PD, G6PC
44wilson disease10.0G6PD, G6PC, CAT
45ischemia10.0HP, G6PC, CAT
46atherosclerosis10.0CAT, G6PD, HP, ACP1
47pre-eclampsia10.0HP, G6PC, CAT
48breast cancer10.0G6PD, HBA1, ACP1
49congenital heart defect10.0CAT, HBA1, HP
50primary hyperoxaluria10.0CAT, G6PC, HP

Graphical network of the top 20 diseases related to Favism:



Diseases related to favism

Clinical Features for Favism

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46OMIM
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Clinical features from OMIM:

134700

Clinical synopsis from OMIM:

134700

Drugs & Therapeutics for Favism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Favism

Drug clinical trials:

Search ClinicalTrials for Favism

Search NIH Clinical Center for Favism

Search CenterWatch for Favism

Genetic Tests for Favism

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22GTR
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Genetic tests related to Favism:

id Genetic test Affiliating Genes
1 Favism, Susceptibility to22

Anatomical Context for Favism

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32MalaCards
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MalaCards organs/tissues related to Favism:

32
Kidney, Breast, Liver

Animal Models for Favism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Favism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5GPX7, HP, G6PC, CAT

Publications for Favism

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50PubMed
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Articles related to Favism:

(show top 50)    (show all 156)
idTitleAuthorsYear
1
Oxidative stress and antioxidant defense in Egyptian favism patients. (23690191)
2013
2
Favism in a 15-month-old baby. (24312948)
2013
3
Diospyros lotus L. fruit extract protects G6PD-deficient erythrocytes from hemolytic injury in vitro and in vivo: prevention of favism disorder. (22195359)
2011
4
An Ashkenazi Jewish woman presenting with favism. (15735168)
2005
5
Molecular identification of mutations in G6PD gene in patients with favism in Iran. (15957246)
2004
6
Favism: effect of divicine on rat erythrocyte sulfhydryl status, hexose monophosphate shunt activity, morphology, and membrane skeletal proteins. (11452148)
2001
7
Favism by proxy in nursing glucose-6-phosphate dehydrogenase-deficient neonates. (9848766)
1998
8
Lactose absorption in patients with glucose 6-phosphate dehydrogenase deficiency with and without favism. (8991858)
1996
9
Haptoglobin therapy for acute favism: a Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara. (7873396)
1995
10
Marked decline of favism after neonatal glucose-6-phosphate dehydrogenase screening and health education: the northern Sardinian experience. (1585769)
1992
11
Epidemiologic study of acute favism cases (G6PD deficiency) in the Autonomous Community of Murcia during 1983-1987. Report of a case]. (2131603)
1990
12
Pathophysiology of favism. (2481620)
1989
13
Desferrioxamine and favism. (3718878)
1986
14
Activity of divicine in Plasmodium vinckei-infected mice has implications for treatment of favism and epidemiology of G-6-PD deficiency. (6743567)
1984
15
Favism: a hemolytic disease associated with increased superoxide dismutase and decreased glutathione peroxidase activities in red blood cells. (6698000)
1984
16
Hemoglobin A1 in subjects with G-6-PD deficiency during and after hemolytic crises due to favism. (6401888)
1983
17
A novel method for quantitation of favism-inducing agents in legumes. (6846790)
1983
18
Mechanisms of red cell clearance in favism. (6675699)
1983
19
Favism--a natural model for the study of hemolytic mechanisms. (6760258)
1982
20
Hingh-performance reversed-phase liquid chromatography (HPLC) of favism-inducing factors in Vicia faba L. (7106247)
1982
21
Hemoglobin Koelliker (alpha 2 minus 141 arg beta 2) in favism. (6805217)
1982
22
Favism: erythrocyte metabolism during haemolysis and reticulocytosis. (41565)
1979
23
Serum glutamic oxalacetic transaminase, glutamic pyruvic transaminase, gamma-glutamyl transpeptidase and glutamic dehydrogenase levels in favism. (43648)
1979
24
Salicylamide-Glucuronide formation in children with favism and in their parents. (821294)
1976
25
A serum defect in favism. (4816791)
1974
26
Urinary D-glucaric acid excretion in normal and G-6-PD-deficient children with favism. (4826626)
1974
27
The interaction between beta-thalassemia, G-6-PD deficiency, and favism. (4528788)
1974
28
L-dopa and favism. (5162316)
1971
29
Favism: association with erythrocyte acid phosphatase phenotype. (5538937)
1971
30
Plasma magnesium during hemolytic crisis in children with favism. (5417236)
1970
31
Family investigations of erythrocyte glucose-6-phosphate dehydrogenase in favism. (5510280)
1970
32
Some clinical and biochemical aspects of favism in childhood. (5351939)
1969
33
G6PD deficiency and favism in the island of Rhodes (Greece). (5345101)
1969
34
The oxidant effect of isouramil on red cell glutathione and its synergistic enhancement by ascorbic acid or 3,4-dihydroxyphenylalanine. Possible relation to the pathogenesis of favism. (5707783)
1968
35
Does 3,4-dihydroxyphenylalanine play a part in favism? (6059514)
1967
36
THE MECHANISM OF HAEMOLYSIS IN FAVISM. SOME ANALOGY IN THE ACTIVITY OF PRIMAQUINE AND FAVA JUICE. (14326932)
1965
37
Immunologic studies in a case of favism. (14453671)
1962
38
Studies on favism. 3. Studies on the physiological activites of vicine in vitro. (13930697)
1962
39
Favism. (13720117)
1961
40
Favism. (20326465)
1960
41
Favism in a Cypriot child. (13828644)
1960
42
Favism--report of a case. (14400102)
1959
43
A suspected case of favism. (13612464)
1958
44
Favism in an English-born child. (13304416)
1956
45
A case of favism. (14368862)
1955
46
Two cases of favism in Israel. (13219366)
1955
47
Nature of favism; case presentation]. (13211128)
1954
48
Favism in London. (13105385)
1953
49
Favism in childhood; a case report. (14884561)
1951
50
Favism; a short review and report of a case. (20248434)
1947

Genetic Variations for Favism

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Expression for genes affiliated with Favism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Favism

Search GEO for disease gene expression data for Favism.

Pathways for genes affiliated with Favism

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37NCBI BioSystems Database, 53Reactome, 29KEGG, 12EMD Millipore
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Pathways related to Favism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6G6PC, CAT
29.5GPX6, CAT
39.1CAT, HBA1, GPX6
48.5GPX6, GPX8, GPX7
5
Hide members
8.5GPX6, GPX7, GPX8
6
Hide members
8.5GPX6, GPX7, GPX8
7
Glutathione metabolism
Hide members
8.2G6PD, GPX8, GPX7, GPX6

Compounds for genes affiliated with Favism

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR
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Compounds related to Favism according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
123-diphosphoglycerate4410.2HP, G6PD
2nadph44 2411.2G6PD, G6PC
3zinc protoporphyrin4410.1G6PD, HP
4pentamidine44 1111.1G6PC, G6PD
5mefloquine44 1111.1G6PD, HBA1
6oxygen44 2411.1G6PC, HBA1
7beta-hydroxybutyrate4410.1G6PC, HP
8sodium azide4410.0G6PD, CAT
9dehydroascorbic acid44 1111.0G6PD, CAT
10vanadium4410.0ACP1, G6PC
11isoniazid49 44 1111.9G6PD, CAT
12probucol44 1110.9CAT, HP
13diamide449.9ACP1, G6PD
14tert-butylhydroperoxide449.8G6PD, CAT
156-phosphogluconate449.8G6PD, ACP1
16thiobarbituric acid449.8HP, G6PD, CAT
17tocopherol449.8CAT, G6PD, HP
18glucose 6-phosphate44 2410.8G6PD, G6PC, CAT
19gssg449.8CAT, G6PD
20vitamin-e449.8CAT, G6PD, HP
21con a449.8HP, G6PC
22trolox449.8ACP1, CAT
23starch449.7ACP1, HP, G6PD
24cellulose acetate449.7ACP1, HP, G6PD
25citrate449.7HP, G6PD, CAT
26mannitol44 1110.7G6PD, G6PC, CAT
278-isoprostane449.7HP, CAT
28alpha lipoic acid449.6ACP1, G6PD, CAT
29hypoxanthine44 11 2411.6ACP1, G6PD, CAT
30copper44 2410.6CAT, G6PC, HP
31diphenyleneiodonium449.6ACP1, G6PD, CAT
32formate449.6G6PD, CAT
33dmso449.6CAT, G6PC, G6PD
34salicylic acid44 2810.6ACP1, G6PD, CAT
35n-ethylmaleimide44 1110.6ACP1, G6PD, CAT
36sodium nitroprusside449.6CAT, G6PD, ACP1
37glycerol44 11 2411.5ACP1, G6PD, G6PC
385-hpete44 2410.5GPX6, GPX7
39sulfasalazine44 28 49 1112.5HP, G6PD
40malondialdehyde449.4HP, G6PD, G6PC, CAT
41uric acid44 2410.4CAT, G6PC, G6PD, HP
42epinephrine44 11 2411.4ACP1, HP, G6PD
43lactate449.4CAT, G6PC, G6PD, HP
44iron44 2410.3HP, HBA1, G6PC, CAT
45aspartate449.3G6PC, G6PD, HP, ACP1
46ascorbic acid44 2410.3CAT, G6PD, HP, ACP1
47adenylate449.2G6PC, G6PD, HP, ACP1
48selenium44 2410.1GPX6, GPX7, CAT
49Glutathione11 249.9GPX8, GPX7, GPX6
50h2o2448.9CAT, G6PC, G6PD, HP, ACP1

GO Terms for genes affiliated with Favism

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16Gene Ontology
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Cellular components related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1internal side of plasma membraneGO:0098989.6ACP1, G6PD

Biological processes related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1triglyceride metabolic processGO:0066419.6G6PC, CAT
2glucose 6-phosphate metabolic processGO:0511569.5G6PD, G6PC
3response to oxidative stressGO:0069798.4GPX6, GPX7, GPX8

Molecular functions related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:0506619.7G6PD, CAT
2antioxidant activityGO:0162099.4HP, CAT
3glutathione peroxidase activityGO:0046028.4GPX6, GPX7, GPX8

Products for genes affiliated with Favism

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Sources for Favism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet