MCID: FVS001
MIFTS: 48

Favism malady

Metabolic diseases category
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Summaries for Favism

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Disease Ontology:8 A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans.

MalaCards based summary: Favism is related to hemolytic anemia and glucosephosphate dehydrogenase deficiency, and has symptoms including An important gene associated with Favism is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and FoxO family signaling. The compounds 23-diphosphoglycerate and zinc protoporphyrin have been mentioned in the context of this disorder. Affiliated tissues include kidney, breast and liver, and related mouse phenotype mortality/aging.

Wikipedia:65 Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) also known as favism (after the fava... more...

Description from OMIM:46 134700

Aliases & Classifications for Favism

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Sources:
8Disease Ontology, 9diseasecard, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt
See all sources

Favism, Aliases & Descriptions:

Name: Favism 8 9 22 46 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology8 DOID:13628
MeSH34 D005236
NCIt39 C34607

Related Diseases for Favism

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Diseases related to Favism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1hemolytic anemia30.6HP, G6PD
2glucosephosphate dehydrogenase deficiency30.4G6PD, HP
3methemoglobinemia30.4G6PD, HP
4malaria30.1G6PD, ACP1, HP
5blackwater fever10.5G6PD
6thalassemia10.3
7congenital hemolytic anemia10.2G6PD, HP
8hemoglobinuria10.2HP, G6PD
9hemoglobinopathy10.2G6PD, HP
10diabetic cataract10.2CAT, G6PD
11senile cataract10.2G6PD, CAT
12autoimmune hemolytic anemia10.2G6PD, HP
13paroxysmal nocturnal hemoglobinuria, somatic10.2HP, G6PD
14bilirubin metabolic disorder10.2HP, G6PD
15chronic granulomatous disease10.2CAT, G6PD
16cerebral malaria10.2HP, G6PD
17polycythemia vera10.2ACP1, G6PD
18plasmodium falciparum malaria10.2HP, G6PD
19tuberculosis10.2ACP1, HP
20respiratory failure10.2CAT, G6PD
21vitiligo10.1CAT, G6PD
22sickle cell disease10.1HP, G6PD
23rheumatoid arthritis10.1HP, ACP1
24alpha thalassemia10.1G6PD, HBA1
25cataract10.1G6PD, CAT
26galactosemia10.0HP, CAT
27beta thalassemia10.0
28syncope10.0
29acute kidney failure10.0CAT, HP, G6PD
30diabetic nephropathy10.0CAT, HP
31pulmonary tuberculosis10.0ACP1, HP, CAT
32vascular disease10.0G6PD, HP, CAT
33metabolic syndrome x10.0ACP1, G6PD, G6PC
34wilson disease10.0G6PC, G6PD, CAT
35congenital heart disease9.9HP, ACP1
36pre-eclampsia9.9CAT, HP, G6PC
37kidney cancer9.9G6PC, ACP1, HP
38primary hyperoxaluria9.9G6PC, HP, CAT
39deficiency anemia9.9HP, G6PD, HBA1
40ischemia9.8G6PC, HP, CAT
41atherosclerosis9.8CAT, HP, ACP1, G6PD
42hypoglycemia9.8G6PC, HBA1
43malignant glioma9.8G6PC, G6PD, ACP1, CAT
44hyperglycemia9.6CAT, ACP1, G6PC, HBA1
45type 2 diabetes mellitus9.6HBA1, G6PC, ACP1, CAT
46diabetes mellitus9.2HBA1, G6PC, G6PD, ACP1, HP, CAT

Graphical network of the top 20 diseases related to Favism:



Diseases related to favism

Symptoms for Favism

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Symptoms by clinical synopsis from OMIM:

134700

Clinical features from OMIM:

134700

HPO human phenotypes related to Favism:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 fava bean-induced hemolytic anemia HP:0004814

Drugs & Therapeutics for Favism

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Drug clinical trials:

Search ClinicalTrials for Favism

Search NIH Clinical Center for Favism

Genetic Tests for Favism

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Genetic tests related to Favism:

id Genetic test Affiliating Genes
1 Favism, Susceptibility to22

Anatomical Context for Favism

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MalaCards organs/tissues related to Favism:

32
Kidney, Breast, Liver

Animal Models for Favism or affiliated genes

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MGI Mouse Phenotypes related to Favism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.6CAT, HP, G6PD, G6PC, HBA1

Publications for Favism

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Articles related to Favism:

(show top 50)    (show all 156)
idTitleAuthorsYear
1
Acute Favism: Methemoglobinemia May Cause Cyanosis and Low Pulse Oximetry Readings. (23697341)
2013
2
Do favic patients resume fava beans ingestion later in their life, a study for this, and a new hypothesis for favism etiology. (23664599)
2013
3
Evaluation of liver and kidney function in favism patients. (23483616)
2013
4
Favism: effect of divicine on rat erythrocyte sulfhydryl status, hexose monophosphate shunt activity, morphology, and membrane skeletal proteins. (11452148)
2001
5
Favism: divicine hemotoxicity in the rat. (10543033)
1999
6
Active involvement of catalase during hemolytic crises of favism. (8704218)
1996
7
Haptoglobin therapy for acute favism: a Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara. (7873396)
1995
8
Variation of favism-inducing factors (vicine, convicine and L-DOPA) during pod development in Vicia faba L. (7659704)
1995
9
Mechanisms of perturbation of erythrocyte calcium homeostasis in favism. (1337501)
1992
10
Recent advances in the biochemistry of favism. (2201290)
1990
11
Glucose-6-phosphate dehydrogenase (G6PD) deficiency in southern Italy: a case of G6PD A(-) associated with favism. (2498187)
1989
12
Desferrioxamine and favism. (3718878)
1986
13
Favism: disordered erythrocyte calcium homeostasis. (2410063)
1985
14
Deferoxamine and favism. (3990722)
1985
15
Biological activities of broad bean (Vicia faba L.) extracts cultivated in South Anatolia in favism sensitive subjects. (6740693)
1984
16
Lymphocyte changes in favism: in vitro evidence of a modifying effect of bilirubin and hemoglobin on T-lymphocyte receptors. (6402878)
1983
17
Hemoglobin A1 in subjects with G-6-PD deficiency during and after hemolytic crises due to favism. (6401888)
1983
18
A novel method for quantitation of favism-inducing agents in legumes. (6846790)
1983
19
Favism and hemolytic anemia in glucose-6-phosphate dehydrogenase-deficient subjects in North Sardinia. (6408883)
1983
20
Favism--a natural model for the study of hemolytic mechanisms. (6760258)
1982
21
The chemistry of favism-inducing compounds. The properties of isouramil and divicine and their reaction with glutathione. (7140776)
1982
22
Effect of divicine and isouramil on red cell metabolism in normal and G6PD-deficient (Mediterranean variant) subjects. Possible role in the genesis of favism. (7291203)
1981
23
Favism in GdMediterranean heterozygous females. (481952)
1979
24
Malaria, favism and glucose-6-phosphate dehydrogenase deficiency. (1107056)
1975
25
A serum defect in favism. (4816791)
1974
26
Serum concentrations of haptoglobin and hemopexin in favism and thalassemia. (4214606)
1974
27
Investigations on favism-inducing toxins in broad beans (Vicia faba L.). (4794968)
1973
28
The epidemiology of favism. (4541143)
1973
29
Biochemical characterization of a glucose-6-phosphate dehydrogenase variant with favism: G-6-PD ZAohringen. (5011553)
1972
30
Favism in Singapore. (5051872)
1972
31
On the pathogenesis of favism. (5149530)
1971
32
Favism in breast-fed infants. (5555486)
1971
33
Some clinical and biochemical aspects of favism in childhood. (5351939)
1969
34
Glucose-6-phosphate-dehydrogenase deficiency and favism. (4187209)
1969
35
The oxidant effect of isouramil on red cell glutathione and its synergistic enhancement by ascorbic acid or 3,4-dihydroxyphenylalanine. Possible relation to the pathogenesis of favism. (5707783)
1968
36
On the familial predisposition to favism. (5944419)
1966
37
Favism in Britain. (5833616)
1965
38
FAVISM IN ENGLAND--TWO MORE CASES. (14294749)
1965
39
Favism in a white South African child. (13941936)
1963
40
Studies on favism. I. Isolation of an active principle from faba beans (Vicia faba). (13930699)
1962
41
Favism. (20326465)
1960
42
Favism in a Cypriot child. (13828644)
1960
43
Favism--report of a case. (14400102)
1959
44
Nature of favism; case presentation]. (13211128)
1954
45
Favism; report of a case and brief review of the literature. (13053334)
1953
46
Favism in Cyprus; analysis of 67 cases admitted to Nicosia General Hospital during the last 3 years. (14926361)
1952
47
Favism. (14887294)
1951
48
Favism in childhood; a case report. (14884561)
1951
49
Favism in Israel. (14888076)
1951
50
Favism. (18879460)
1948

Variations for Favism

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Expression for genes affiliated with Favism

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Expression patterns in normal tissues for genes affiliated with Favism

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Pathways for genes affiliated with Favism

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Pathways related to Favism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4HP, HBA1
29.1CAT, G6PC
3
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.1CAT, G6PC
4
Show member pathways
thioredoxin pathway37
9.0CAT, HBA1
5
Show member pathways
8.1HBA1, G6PC, G6PD, CAT

Compounds for genes affiliated with Favism

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Favism according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
123-diphosphoglycerate4410.0HP, G6PD
2zinc protoporphyrin449.9G6PD, HP
3dimercaprol44 5010.9G6PD, ACP1
4pentamidine44 1110.9G6PD, G6PC
5beta-hydroxybutyrate449.8G6PC, HP
6diamide449.8G6PD, ACP1
7vanadium449.8G6PC, ACP1
8mefloquine44 50 1111.8HBA1, G6PD
96-phosphogluconate449.8G6PD, ACP1
10sodium azide449.5G6PD, CAT
11dehydroascorbic acid44 1110.5G6PD, CAT
12starch449.5G6PD, ACP1, HP
13cellulose acetate449.5HP, ACP1, G6PD
14con a449.5HP, G6PC
15isoniazid44 50 1111.4CAT, G6PD
16probucol44 1110.4CAT, HP
17trolox449.4ACP1, CAT
18tert-butylhydroperoxide449.4CAT, G6PD
19glycerol44 24 1111.4G6PD, G6PC, ACP1
20epinephrine44 24 1111.4G6PD, ACP1, HP
21gssg449.3G6PD, CAT
22thiobarbituric acid449.2G6PD, HP, CAT
23tocopherol449.2G6PD, CAT, HP
24vitamin-e449.2G6PD, HP, CAT
25citrate449.2HP, CAT, G6PD
26alpha lipoic acid449.1ACP1, CAT, G6PD
27hypoxanthine44 24 1111.1G6PD, CAT, ACP1
28diphenyleneiodonium449.1CAT, ACP1, G6PD
29salicylic acid44 2810.1ACP1, G6PD, CAT
30rapamycin449.1G6PC, ACP1, G6PD
31n-ethylmaleimide44 1110.1ACP1, G6PD, CAT
32sodium nitroprusside449.1ACP1, G6PD, CAT
33mannitol44 1110.1G6PC, G6PD, CAT
34dmso449.1G6PD, CAT, G6PC
35copper44 2410.0CAT, HP, G6PC
36aspartate449.0G6PD, ACP1, G6PC, HP
37adenylate449.0G6PC, HP, ACP1, G6PD
38nadh44 24 1110.9G6PC, G6PD, CAT
39doxorubicin44 50 1110.7CAT, G6PD, ACP1
40malondialdehyde448.7G6PC, HP, CAT, G6PD
41uric acid44 249.7G6PC, G6PD, CAT, HP
42glucose 6-phosphate44 249.7HP, CAT, G6PC, G6PD
43ascorbic acid44 249.7HP, G6PD, ACP1, CAT
44lactate448.7CAT, HP, G6PD, G6PC
45nadph44 249.6CAT, ACP1, G6PD, G6PC
46actinomycin d448.5CAT, HP, G6PD
47iron44 249.5G6PC, HBA1, CAT, HP
48h2o2448.2G6PC, HP, CAT, G6PD, ACP1
49lipid448.2CAT, G6PC, G6PD, HP
50oxygen44 249.0CAT, HBA1, G6PD, G6PC, ACP1

GO Terms for genes affiliated with Favism

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Cellular components related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:0098989.5ACP1, G6PD

Biological processes related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose 6-phosphate metabolic processGO:0511569.2G6PD, G6PC
2triglyceride metabolic processGO:0066419.1CAT, G6PC

Molecular functions related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:0506619.2CAT, G6PD
2antioxidant activityGO:0162098.9CAT, HP

Products for genes affiliated with Favism

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  • Antibodies
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Sources for Favism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet