Aliases & Classifications for Favism

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Sources:
45OMIM, 10diseasecard, 11DISEASES, 43Novoseek, 22GTR, 60UMLS
See all sources

Favism, Aliases & Descriptions:

Name: Favism 45 10 11 43 22 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


External Ids:

OMIM45 134700

Summaries for Favism

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OMIM:45 Hemolytic anemia following ingestion of the bean of Vicia faba or exposure to its pollen is conditioned primarily by a... (134700) more...

MalaCards based summary: Favism is related to glucose-6-phosphate dehydrogenase deficiency and hemolytic anemia, and has symptoms including autosomal dominant inheritanceand fava bean-induced hemolytic anemia. An important gene associated with Favism is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and FoxO family signaling. The compounds 23-diphosphoglycerate and zinc protoporphyrin have been mentioned in the context of this disorder. Affiliated tissues include kidney, breast and liver, and related mouse phenotype mortality/aging.

Wikipedia:63 Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) also known as favism (after the fava... more...

Related Diseases for Favism

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Diseases related to Favism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1glucose-6-phosphate dehydrogenase deficiency31.2G6PD, HP
2hemolytic anemia30.6HP, G6PD
3thalassemia30.5G6PD, HBA1
4methemoglobinemia30.4G6PD, HP
5malaria30.3HP, G6PD
6blackwater fever10.5G6PD
7sickle cell anemia10.2G6PD, HP
8congenital hemolytic anemia10.2G6PD, HP
9glucosephosphate dehydrogenase deficiency10.2G6PD, HP
10hemoglobinuria10.2HP, G6PD
11hemoglobinopathy10.2G6PD, HP
12diabetic cataract10.2CAT, G6PD
13senile cataract10.2G6PD, CAT
14autoimmune hemolytic anemia10.2G6PD, HP
15paroxysmal nocturnal hemoglobinuria10.2HP, G6PD
16bilirubin metabolic disorder10.2HP, G6PD
17chronic granulomatous disease10.2CAT, G6PD
18polycythemia vera10.2ACP1, G6PD
19plasmodium falciparum malaria10.2HP, G6PD
20tuberculosis10.2ACP1, HP
21respiratory failure10.2CAT, G6PD
22vitiligo-associated multiple autoimmune disease susceptibility 110.1CAT, G6PD
23sickle cell disease10.1HP, G6PD
24thalassemias, alpha-10.1HBA1, G6PD
25rheumatoid arthritis10.1HP, ACP1
26cataract10.1G6PD, CAT
27syncope10.0
28liver disease10.0HP, CAT
29acute kidney failure10.0CAT, HP, G6PD
30microvascular complications of diabetes 310.0CAT, HP
31pulmonary tuberculosis10.0ACP1, HP, CAT
32vascular disease10.0G6PD, HP, CAT
33metabolic syndrome x10.0ACP1, G6PD, G6PC
34wilson disease10.0G6PC, G6PD, CAT
35congenital heart disease9.9HP, ACP1
36preeclampsia/eclampsia 19.9CAT, HP, G6PC
37kidney cancer9.9G6PC, ACP1, HP
38primary hyperoxaluria9.9G6PC, HP, CAT
39deficiency anemia9.9HP, G6PD, HBA1
40ischemia9.8G6PC, HP, CAT
41atherosclerosis9.8CAT, HP, ACP1, G6PD
42hypoglycemia9.8G6PC, HBA1
43malignant glioma9.8G6PC, G6PD, ACP1, CAT
44hyperglycemia9.6CAT, ACP1, G6PC, HBA1
45diabetes mellitus, noninsulin-dependent9.6HBA1, G6PC, ACP1, CAT
46diabetes mellitus, insulin-dependent9.2HBA1, G6PC, G6PD, ACP1, HP, CAT

Graphical network of the top 20 diseases related to Favism:



Diseases related to favism

Symptoms for Favism

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Symptoms by clinical synopsis from OMIM:

134700

Clinical features from OMIM:

134700

HPO human phenotypes related to Favism:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 fava bean-induced hemolytic anemia HP:0004814

Drugs & Therapeutics for Favism

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Drug clinical trials:

Search ClinicalTrials for Favism

Search NIH Clinical Center for Favism

Genetic Tests for Favism

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Genetic tests related to Favism:

id Genetic test Affiliating Genes
1 Favism, Susceptibility to22

Anatomical Context for Favism

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MalaCards organs/tissues related to Favism:

31
Kidney, Breast, Liver

Animal Models for Favism or affiliated genes

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MGI Mouse Phenotypes related to Favism:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.6CAT, HP, G6PD, G6PC, HBA1

Publications for Favism

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Articles related to Favism:

(show top 50)    (show all 158)
idTitleAuthorsYear
1
Acute Favism: Methemoglobinemia May Cause Cyanosis and Low Pulse Oximetry Readings. (23697341)
2013
2
Do favic patients resume fava beans ingestion later in their life, a study for this, and a new hypothesis for favism etiology. (23664599)
2013
3
Evaluation of liver and kidney function in favism patients. (23483616)
2013
4
Favism: effect of divicine on rat erythrocyte sulfhydryl status, hexose monophosphate shunt activity, morphology, and membrane skeletal proteins. (11452148)
2001
5
Favism: divicine hemotoxicity in the rat. (10543033)
1999
6
Active involvement of catalase during hemolytic crises of favism. (8704218)
1996
7
Haptoglobin therapy for acute favism: a Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara. (7873396)
1995
8
Variation of favism-inducing factors (vicine, convicine and L-DOPA) during pod development in Vicia faba L. (7659704)
1995
9
Mechanisms of perturbation of erythrocyte calcium homeostasis in favism. (1337501)
1992
10
Recent advances in the biochemistry of favism. (2201290)
1990
11
Glucose-6-phosphate dehydrogenase (G6PD) deficiency in southern Italy: a case of G6PD A(-) associated with favism. (2498187)
1989
12
Pathophysiology of favism. (2481620)
1989
13
Desferrioxamine and favism. (3718878)
1986
14
Favism: disordered erythrocyte calcium homeostasis. (2410063)
1985
15
Deferoxamine and favism. (3990722)
1985
16
Biological activities of broad bean (Vicia faba L.) extracts cultivated in South Anatolia in favism sensitive subjects. (6740693)
1984
17
Lymphocyte changes in favism: in vitro evidence of a modifying effect of bilirubin and hemoglobin on T-lymphocyte receptors. (6402878)
1983
18
Hemoglobin A1 in subjects with G-6-PD deficiency during and after hemolytic crises due to favism. (6401888)
1983
19
A novel method for quantitation of favism-inducing agents in legumes. (6846790)
1983
20
Favism and hemolytic anemia in glucose-6-phosphate dehydrogenase-deficient subjects in North Sardinia. (6408883)
1983
21
Favism--a natural model for the study of hemolytic mechanisms. (6760258)
1982
22
The chemistry of favism-inducing compounds. The properties of isouramil and divicine and their reaction with glutathione. (7140776)
1982
23
Effect of divicine and isouramil on red cell metabolism in normal and G6PD-deficient (Mediterranean variant) subjects. Possible role in the genesis of favism. (7291203)
1981
24
Favism in GdMediterranean heterozygous females. (481952)
1979
25
Malaria, favism and glucose-6-phosphate dehydrogenase deficiency. (1107056)
1975
26
A serum defect in favism. (4816791)
1974
27
Serum concentrations of haptoglobin and hemopexin in favism and thalassemia. (4214606)
1974
28
Investigations on favism-inducing toxins in broad beans (Vicia faba L.). (4794968)
1973
29
The epidemiology of favism. (4541143)
1973
30
Biochemical characterization of a glucose-6-phosphate dehydrogenase variant with favism: G-6-PD ZAohringen. (5011553)
1972
31
Favism in Singapore. (5051872)
1972
32
On the pathogenesis of favism. (5149530)
1971
33
Favism in breast-fed infants. (5555486)
1971
34
Some clinical and biochemical aspects of favism in childhood. (5351939)
1969
35
Glucose-6-phosphate-dehydrogenase deficiency and favism. (4187209)
1969
36
The oxidant effect of isouramil on red cell glutathione and its synergistic enhancement by ascorbic acid or 3,4-dihydroxyphenylalanine. Possible relation to the pathogenesis of favism. (5707783)
1968
37
On the familial predisposition to favism. (5944419)
1966
38
Favism in Britain. (5833616)
1965
39
FAVISM IN ENGLAND--TWO MORE CASES. (14294749)
1965
40
Favism in a white South African child. (13941936)
1963
41
Studies on favism. I. Isolation of an active principle from faba beans (Vicia faba). (13930699)
1962
42
Favism. (20326465)
1960
43
Favism in a Cypriot child. (13828644)
1960
44
Favism--report of a case. (14400102)
1959
45
Nature of favism; case presentation]. (13211128)
1954
46
Favism in Cyprus; analysis of 67 cases admitted to Nicosia General Hospital during the last 3 years. (14926361)
1952
47
Favism. (14887294)
1951
48
Favism in childhood; a case report. (14884561)
1951
49
Favism in Israel. (14888076)
1951
50
Favism. (18879460)
1948

Variations for Favism

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Expression for genes affiliated with Favism

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Search GEO for disease gene expression data for Favism.

Pathways for genes affiliated with Favism

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Pathways related to Favism according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4HP, HBA1
29.1CAT, G6PC
3
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
9.1CAT, G6PC
4
Show member pathways
thioredoxin pathway36
9.0CAT, HBA1
5
Show member pathways
8.1HBA1, G6PC, G6PD, CAT

Compounds for genes affiliated with Favism

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Sources:
43Novoseek, 49PharmGKB, 12DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Favism according to GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
123-diphosphoglycerate4310.0HP, G6PD
2zinc protoporphyrin439.9G6PD, HP
3dimercaprol43 4910.9G6PD, ACP1
4pentamidine43 1210.9G6PD, G6PC
5beta-hydroxybutyrate439.8G6PC, HP
6diamide439.8G6PD, ACP1
7vanadium439.8G6PC, ACP1
8mefloquine43 49 1211.8HBA1, G6PD
96-phosphogluconate439.8G6PD, ACP1
10sodium azide439.5G6PD, CAT
11dehydroascorbic acid43 1210.5G6PD, CAT
12starch439.5G6PD, ACP1, HP
13cellulose acetate439.5HP, ACP1, G6PD
14con a439.5HP, G6PC
15isoniazid43 49 1211.4CAT, G6PD
16probucol43 1210.4CAT, HP
17trolox439.4ACP1, CAT
18tert-butylhydroperoxide439.4CAT, G6PD
19glycerol43 24 1211.4G6PD, G6PC, ACP1
20epinephrine43 24 1211.4G6PD, ACP1, HP
21gssg439.3G6PD, CAT
22thiobarbituric acid439.2G6PD, HP, CAT
23tocopherol439.2G6PD, CAT, HP
24vitamin-e439.2G6PD, HP, CAT
25citrate439.2HP, CAT, G6PD
26alpha lipoic acid439.1ACP1, CAT, G6PD
27hypoxanthine43 24 1211.1G6PD, CAT, ACP1
28diphenyleneiodonium439.1CAT, ACP1, G6PD
29salicylic acid43 2810.1ACP1, G6PD, CAT
30rapamycin439.1G6PC, ACP1, G6PD
31n-ethylmaleimide43 1210.1ACP1, G6PD, CAT
32sodium nitroprusside439.1ACP1, G6PD, CAT
33mannitol43 1210.1G6PC, G6PD, CAT
34dmso439.1G6PD, CAT, G6PC
35copper43 2410.0CAT, HP, G6PC
36aspartate439.0G6PD, ACP1, G6PC, HP
37adenylate439.0G6PC, HP, ACP1, G6PD
38nadh43 24 1210.9G6PC, G6PD, CAT
39doxorubicin43 49 1210.7CAT, G6PD, ACP1
40malondialdehyde438.7G6PC, HP, CAT, G6PD
41uric acid43 249.7G6PC, G6PD, CAT, HP
42glucose 6-phosphate43 249.7HP, CAT, G6PC, G6PD
43ascorbic acid43 249.7HP, G6PD, ACP1, CAT
44lactate438.7CAT, HP, G6PD, G6PC
45nadph43 249.6CAT, ACP1, G6PD, G6PC
46actinomycin d438.5CAT, HP, G6PD
47iron43 249.5G6PC, HBA1, CAT, HP
48h2o2438.2G6PC, HP, CAT, G6PD, ACP1
49lipid438.2CAT, G6PC, G6PD, HP
50oxygen43 249.0CAT, HBA1, G6PD, G6PC, ACP1

GO Terms for genes affiliated with Favism

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Cellular components related to Favism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:00098989.5ACP1, G6PD

Biological processes related to Favism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glucose 6-phosphate metabolic processGO:00511569.2G6PD, G6PC
2triglyceride metabolic processGO:00066419.1CAT, G6PC

Molecular functions related to Favism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:00506619.2CAT, G6PD
2antioxidant activityGO:00162098.9CAT, HP

Products for genes affiliated with Favism

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  • Antibodies
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Sources for Favism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet