MCID: FVS001
MIFTS: 46

Favism malady

Summaries for Favism

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans.

MalaCards: Favism is related to glucosephosphate dehydrogenase deficiency and hemolytic anemia. An important gene associated with Favism is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are FoxO family signaling and Folate Metabolism. The compounds 23-diphosphoglycerate and nadph have been mentioned in the context of this disorder. Affiliated tissues include kidney, breast and liver, and related mouse phenotype tumorigenesis.

Wikipedia:63 Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is an X-linked recessive hereditary... more...

Description from OMIM:46 134700

Aliases & Classifications for Favism

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8Disease Ontology, 9diseasecard, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

favism 8 9 22 46 10 44 60


External Ids:

Disease Ontology8 DOID:13628
MeSH34 D005236
NCIt39 C34607

Related Diseases for Favism

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17GeneCards, 18GeneDecks
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Diseases related to Favism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1glucosephosphate dehydrogenase deficiency30.3G6PD, HP
2hemolytic anemia30.3HP, G6PD
3deficiency anemia30.1HP, HBA1, G6PD
4methemoglobinemia29.9HP, G6PD
5malaria29.9ACP1, HP, G6PD
6thalassemia10.2
7neonatal jaundice10.0G6PD
8blackwater fever10.0G6PD
9liver cirrhosis10.0HP
10obesity10.0ACP1
11viral hepatitis10.0G6PD
12polycythemia10.0G6PD
13microcytic anemia10.0G6PD
14leishmaniasis10.0ACP1
15iron deficiency anemia10.0G6PD
16nephrotic syndrome10.0HP
17hyperuricemia10.0G6PC
18sickle cell anemia10.0G6PD, HP
19congenital hemolytic anemia10.0G6PD, HP
20hemoglobinopathy10.0HP, G6PD
21paroxysmal nocturnal hemoglobinuria10.0HP, G6PD
22congenital hypothyroidism10.0G6PD
23sickle cell disease10.0HP, G6PD
24bilirubin metabolic disorder10.0HP, G6PD
25cerebral malaria10.0HP, G6PD
26meningitis10.0CAT
27beta thalassemia10.0
28plasmodium falciparum malaria10.0G6PD, HP
29keshan disease10.0GPX8, GPX6
30diabetic cataract10.0G6PD, CAT
31senile cataract10.0G6PD, CAT
32chronic granulomatous disease10.0G6PD, CAT
33hepatocellular carcinoma10.0ACP1, G6PC
34glioblastoma multiforme10.0ACP1, G6PC
35respiratory failure10.0G6PD, CAT
36alpha thalassemia10.0HBA1, G6PD
37insulin resistance10.0ACP1, G6PC
38acute kidney failure10.0CAT, G6PD, HP
39autoimmune hemolytic anemia10.0HP, G6PD
40pulmonary tuberculosis10.0ACP1, HP, CAT
41vascular disease10.0CAT, G6PD, HP
42hypertrophy of breast10.0ACP1, HP, G6PD
43metabolic syndrome x10.0ACP1, G6PD, G6PC
44wilson disease10.0G6PD, G6PC, CAT
45ischemia10.0HP, G6PC, CAT
46atherosclerosis10.0CAT, G6PD, HP, ACP1
47pre-eclampsia10.0HP, G6PC, CAT
48breast cancer10.0G6PD, HBA1, ACP1
49congenital heart defect10.0CAT, HBA1, HP
50primary hyperoxaluria10.0CAT, G6PC, HP

Graphical network of the top 20 diseases related to Favism:



Diseases related to favism

Clinical Features for Favism

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46OMIM
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Clinical features from OMIM:

134700

Clinical synopsis from OMIM:

134700

Drugs & Therapeutics for Favism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Favism

Drug clinical trials:

Search ClinicalTrials for Favism

Search NIH Clinical Center for Favism

Search CenterWatch for Favism

Genetic Tests for Favism

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22GTR
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Genetic tests related to Favism:

id Genetic test Affiliating Genes
1 Favism, Susceptibility to22

Anatomical Context for Favism

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32MalaCards
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MalaCards organs/tissues related to Favism:

32
Kidney, Breast, Liver

Animal Models for Favism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Favism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5GPX7, HP, G6PC, CAT

Publications for Favism

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50PubMed
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Articles related to Favism:

(show top 50)    (show all 156)
idTitleAuthorsYear
1
Acute Favism: Methemoglobinemia May Cause Cyanosis and Low Pulse Oximetry Readings. (23697341)
2013
2
Do favic patients resume fava beans ingestion later in their life, a study for this, and a new hypothesis for favism etiology. (23664599)
2013
3
Evaluation of liver and kidney function in favism patients. (23483616)
2013
4
An unusual syncope cause in the ED: favism. (20930025)
2011
5
Association between ACP(1) genetic polymorphism and favism. (21644204)
2011
6
Drug-eluting stents in a patient with favism: is the aspirin administration safe? (18852594)
2008
7
Glucose-6-phosphate dehydrogenase variants associated with favism in Thai children. (16513531)
2006
8
Several mutations including two novel mutations of the glucose-6-phosphate dehydrogenase gene in Polish G6PD deficient subjects with chronic nonspherocytic hemolytic anemia, acute hemolytic anemia, and favism. (10571945)
1999
9
Active involvement of catalase during hemolytic crises of favism. (8704218)
1996
10
Glucose-6-phosphate: a key compound in glycogenosis I and favism leading to hyper- or hypolipidaemia. (8319730)
1993
11
G6PD Aures: a new mutation (48 Ile-->Thr) causing mild G6PD deficiency is associated with favism. (8490627)
1993
12
Mechanisms of perturbation of erythrocyte calcium homeostasis in favism. (1337501)
1992
13
Recent advances in the biochemistry of favism. (2201290)
1990
14
Alterations of red blood cell proteolysis in favism. (3036108)
1987
15
Contributions of superoxide, hydrogen peroxide, and transition metal ions to auto-oxidation of the favism-inducing pyrimidine aglycone, divicine, and its reactions with haemoglobin. (3013207)
1986
16
Favism: disordered erythrocyte calcium homeostasis. (2410063)
1985
17
Biological activities of broad bean (Vicia faba L.) extracts cultivated in South Anatolia in favism sensitive subjects. (6740693)
1984
18
Lymphocyte changes in favism: in vitro evidence of a modifying effect of bilirubin and hemoglobin on T-lymphocyte receptors. (6402878)
1983
19
Effect of divicine and isouramil on red cell metabolism in normal and G6PD-deficient (Mediterranean variant) subjects. Possible role in the genesis of favism. (7291203)
1981
20
Favism in GdMediterranean heterozygous females. (481952)
1979
21
Haemopexin behaviour in an acute hyperhaemolytic crisis secondary to favism (erythrocyte glucose-6-phosphate dehydrogenase deficiency). (866908)
1977
22
Investigations on favism-inducing toxins in broad beans (Vicia faba L.). (4794968)
1973
23
The epidemiology of favism. (4541143)
1973
24
Favism: current problems and investigations. (4714581)
1973
25
Biochemical characterization of a glucose-6-phosphate dehydrogenase variant with favism: G-6-PD ZAohringen. (5011553)
1972
26
On the pathogenesis of favism. (5149530)
1971
27
Favism in breast-fed infants. (5555486)
1971
28
Favism in breast-fed infants. (5118085)
1971
29
Favism in the Caspian littoral area of Iran. (5568540)
1971
30
Favism, with special reference to Iran. (5306718)
1969
31
On the familial predisposition to favism. (5944419)
1966
32
The kidney in haemoglobinuric favism. (5911187)
1966
33
FAVISM IN ENGLAND--TWO MORE CASES. (14294749)
1965
34
Studies on favism in Kwangtung Province. (5873774)
1965
35
FAVISM IN AUSTRALIA. (14321235)
1965
36
Favism and thalassemia minor in a pregnant woman. (13875561)
1962
37
Favism: a family study. (13883850)
1962
38
Studies on favism. 2. Studies on the physiological activities of vicine in vivo. (13930698)
1962
39
OPHTHALMOLOGICAL COMPLICATIONS OF FAVISM. (18170640)
1960
40
Severe opthalmologic complications following favism. (13810004)
1960
41
Serologic studies on favism. (13630642)
1959
42
A deficiency of glucose-6-phosphate dehydrogenase activity in erythrocytes from patients with favism. (13523280)
1958
43
Favism; case report showing heredofamilial tendency. (13476327)
1957
44
Studies on erthrocytes in cases with past history of favism and drug-induced acute hemolytic anemia. (13436516)
1957
45
Bilateral cortical necrosis of the kidneys in an infant with favism. (13292383)
1956
46
A case of favism]. (13244689)
1955
47
Favism; report of a case occurring in Johannesburg. (13290928)
1955
48
Treatment of favism with cortisone. (13174371)
1954
49
Favism in two children in California. (15430105)
1950
50
Favism. (18879460)
1948

Genetic Variations for Favism

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Expression for genes affiliated with Favism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Favism

Search GEO for disease gene expression data for Favism.

Pathways for genes affiliated with Favism

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37NCBI BioSystems Database, 53Reactome, 29KEGG, 12EMD Millipore
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Pathways related to Favism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6G6PC, CAT
29.5GPX6, CAT
39.1CAT, HBA1, GPX6
48.5GPX6, GPX8, GPX7
5
Hide members
8.5GPX6, GPX7, GPX8
6
Hide members
8.5GPX6, GPX7, GPX8
7
Glutathione metabolism
Hide members
8.2G6PD, GPX8, GPX7, GPX6

Compounds for genes affiliated with Favism

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR
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Compounds related to Favism according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
123-diphosphoglycerate4410.2HP, G6PD
2nadph44 2411.2G6PD, G6PC
3zinc protoporphyrin4410.1G6PD, HP
4pentamidine44 1111.1G6PC, G6PD
5mefloquine44 1111.1G6PD, HBA1
6oxygen44 2411.1G6PC, HBA1
7beta-hydroxybutyrate4410.1G6PC, HP
8sodium azide4410.0CAT, G6PD
9dehydroascorbic acid44 1111.0G6PD, CAT
10vanadium4410.0ACP1, G6PC
11isoniazid49 44 1111.9G6PD, CAT
12probucol44 1110.9CAT, HP
13diamide449.9ACP1, G6PD
14tert-butylhydroperoxide449.8G6PD, CAT
156-phosphogluconate449.8G6PD, ACP1
16thiobarbituric acid449.8G6PD, CAT, HP
17tocopherol449.8HP, G6PD, CAT
18glucose 6-phosphate44 2410.8G6PC, G6PD, CAT
19gssg449.8G6PD, CAT
20vitamin-e449.8CAT, G6PD, HP
21con a449.8G6PC, HP
22trolox449.8ACP1, CAT
23starch449.7G6PD, HP, ACP1
24cellulose acetate449.7ACP1, HP, G6PD
25citrate449.7G6PD, CAT, HP
26mannitol44 1110.7G6PD, G6PC, CAT
278-isoprostane449.7CAT, HP
28alpha lipoic acid449.6ACP1, G6PD, CAT
29hypoxanthine44 11 2411.6ACP1, CAT, G6PD
30copper44 2410.6G6PC, HP, CAT
31diphenyleneiodonium449.6G6PD, ACP1, CAT
32formate449.6G6PD, CAT
33dmso449.6G6PD, G6PC, CAT
34salicylic acid44 2810.6ACP1, G6PD, CAT
35n-ethylmaleimide44 1110.6CAT, ACP1, G6PD
36sodium nitroprusside449.6G6PD, ACP1, CAT
37glycerol44 11 2411.5G6PD, ACP1, G6PC
385-hpete44 2410.5GPX7, GPX6
39sulfasalazine44 28 49 1112.5HP, G6PD
40malondialdehyde449.4HP, G6PD, G6PC, CAT
41uric acid44 2410.4HP, CAT, G6PC, G6PD
42epinephrine44 11 2411.4ACP1, HP, G6PD
43lactate449.4CAT, G6PC, HP, G6PD
44iron44 2410.3CAT, G6PC, HBA1, HP
45aspartate449.3G6PD, ACP1, HP, G6PC
46ascorbic acid44 2410.3ACP1, HP, G6PD, CAT
47adenylate449.2G6PC, HP, ACP1, G6PD
48selenium44 2410.1CAT, GPX7, GPX6
49Glutathione11 249.9GPX7, GPX6, GPX8
50h2o2448.9CAT, G6PC, G6PD, HP, ACP1

GO Terms for genes affiliated with Favism

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16Gene Ontology
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Cellular components related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1internal side of plasma membraneGO:0098989.6ACP1, G6PD

Biological processes related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1triglyceride metabolic processGO:0066419.6G6PC, CAT
2glucose 6-phosphate metabolic processGO:0511569.5G6PD, G6PC
3response to oxidative stressGO:0069798.4GPX6, GPX7, GPX8

Molecular functions related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:0506619.7G6PD, CAT
2antioxidant activityGO:0162099.4HP, CAT
3glutathione peroxidase activityGO:0046028.4GPX6, GPX7, GPX8

Products for genes affiliated with Favism

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  • Antibodies
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Sources for Favism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet