Favism malady

Disease Ontology: A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans.⁶

MalaCards: Favism is related to glucosephosphate dehydrogenase deficiency and hemolytic anemia. An important gene associated with Favism is G6PD (glucose-6-phosphate dehydrogenase). The compounds n-ethylmaleimide and nadph have been mentioned in the context of this disorder. Affiliated tissues include whole blood.

Wikipedia: Glucose-6-phosphate dehydrogenase deficiency is an X-linked recessive hereditary disease characterised...⁴⁴ more...

Aliases & Descriptions:

favism 6 7 8 33 32 43

Diseases related to favism by text searches and GeneDecks gene sharing:

(show top 50)    (show all 106)

id	Related Disease	Score	Top Affiliating Genes
1	glucosephosphate dehydrogenase deficiency	29.6	HP, G6PD
2	hemolytic anemia	28.0	G6PD, HP
3	anemia	25.5	HP, CAT, G6PD, ACP1, HBA1
4	blackwater fever	13.1	G6PD, HP
5	congenital hemolytic anemia	13.1	G6PD, HP
6	hemoglobinopathy	13.0	G6PD, HP
7	diabetic cataract	13.0	CAT, G6PD
8	aseptic meningitis	13.0	G6PD, CAT
9	paroxysmal nocturnal hemoglobinuria	13.0	HP, G6PD
10	hereditary elliptocytosis	13.0	G6PD, HP
11	bilirubin metabolic disorder	13.0	HP, G6PD
12	priapism	13.0	HP, G6PD
13	hyperphenylalaninemia	13.0	CAT, G6PD
14	elliptocytosis	13.0	G6PD, HP
15	senile cataract	13.0	G6PD, CAT
16	cerebral malaria	13.0	G6PD, HP
17	asbestosis	13.0	CAT, G6PD
18	hereditary spherocytosis	13.0	G6PD, HP
19	spherocytosis	13.0	HP, G6PD
20	respiratory failure	13.0	CAT, G6PD
21	multinodular goiter	13.0	CAT, G6PD
22	iron deficiency anemia	12.9	G6PD, CAT
23	congenital hypothyroidism	12.9	G6PD, HP
24	autoimmune hemolytic anemia	12.9	G6PD, HP
25	galactosemia	12.9	G6PD, G6PC
26	guillain-barre syndrome	12.8	ACP1, HP
27	chronic granulomatous disease	12.8	G6PD, CAT
28	glycogen storage disease type ia	12.8	G6PC, CAT
29	cholelithiasis	12.8	HP, G6PD
30	phenylketonuria	12.8	CAT, G6PD
31	cholecystitis	12.8	HP, CAT
32	hemoglobinuria	12.8	HP, G6PD
33	alpha thalassemia	12.7	G6PD, HBA1
34	hydrops fetalis	12.7	HBA1, G6PD
35	cutaneous leishmaniasis	12.7	G6PD, CAT
36	neonatal jaundice	12.6	ACP1, G6PD, HP
37	insomnia	12.6	HBA1, CAT
38	leishmaniasis	12.6	ACP1, G6PD, CAT
39	plasmodium falciparum malaria	12.5	G6PD, HP
40	rheumatic fever	12.5	HP, G6PD, CAT
41	dyserythropoietic anemia with thrombocytopenia	12.5	HBA1, HP
42	acne	12.5	G6PD, HP, CAT
43	viral hepatitis	12.5	CAT, HP, G6PD
44	hypertrophy of breast	12.5	HP, G6PD, ACP1
45	vascular disease	12.5	G6PD, HP, CAT
46	pulmonary tuberculosis	12.5	HP, ACP1, CAT
47	alcohol abuse	12.5	ACP1, HP, CAT
48	convulsions	12.5	CAT, HP, ACP1
49	age related macular degeneration	12.5	HP, G6PD, CAT
50	spontaneous abortion	12.5	HP, ACP1, CAT

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to favism:

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Articles related to favism:

(show all 18)

id	Title	Authors	Year	Affiliating Genes
1	Drug-eluting stents in a patient with favism: is the aspirin administration safe? (18852594)	Rigattieri S.... Loschiavo P.	2008	G6PD
2	Glucose-6-phosphate dehydrogenase variants associated with favism in Thai children. (16513531)	Laosombat V.... Wongchanchailert M.	2006	G6PD
3	Molecular identification of mutations in G6PD gene in patients with favism in Iran. (15957246)	Noori-Daloii M.R.... Sanati M.H.	2004	G6PD
4	Favism (11155491)	Oliveira S.... Castro A.S.	2000	G6PD
5	Several mutations including two novel mutations of the glucose-6-phosphate dehydrogenase gene in Polish G6PD deficient subjects with chronic nonspherocytic hemolytic anemia, acute hemolytic anemia, and favism. (10571945)	Jablonska-Skwiecinska E.... Burzynska B.	1999	G6PD
6	Favism by proxy in nursing glucose-6-phosphate dehydrogenase-deficient neonates. (9848766)	Kaplan M.... Stevenson D.K.	1998	G6PD
7	Association between ACP1 and favism: a possible bioch emical mechanism. (9116311)	Bottini E.... Businco L.	1997	ACP1
8	Active involvement of catalase during hemolytic crises of favism. (8704218)	Gaetani G.F.... Ferraris A.M.	1996	CAT, G6PD
9	Lactose absorption in patients with glucose 6-phosphate dehydrogenase deficiency with and without favism. (8991858)	Meloni T.... Meloni G.F.	1996	G6PD
10	Favism in a female newborn infant whose mother ingested fava beans before delivery. (7472841)	Corchia C.... Meloni T.	1995	G6PD
11	Haptoglobin therapy for acute favism: a Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara. (7873396)	Ohga S.... Ueda K.	1995	G6PD, HP
12	Glucose-6-phosphate: a key compound in glycogenosis I and favism leading to hyper- or hypolipidaemia. (8319730)	Schmitz G.... Ullrich K.	1993	G6PC, G6PD
13	G6PD Aures: a new mutation (48 Ile-->Thr) causing mild G6PD deficiency is associated with favism. (8490627)	Nafa K.... Luzzatto L.	1993	G6PD
14	Mechanisms of perturbation of erythrocyte calcium homeostasis in favism. (1337501)	Damonte G.... De Flora A.	1992	G6PD
15	Marked decline of favism after neonatal glucose-6-phosphate dehydrogenase screening and health education: the northern Sardinian experience. (1585769)	Meloni T.... Meloni G.F.	1992	G6PD
16	Favism in the African type of glucose-6-phosphate dehydrogenase deficiency (A-). (2106932)	Galiano S.... Luzzatto L.	1990	G6PD
17	Epidemiologic study of acute favism cases (G6PD defi ciency) in the Autonomous Community of Murcia during 1983-1987. Report of a cas e (2131603)	PereA+iguez Barranco J.E.... UreA+a Adrover P.	1990	G6PD
18	Hemoglobin Koelliker (alpha 2 minus 141 arg beta 2) in favism. (6805217)	Schiliro G.... Azzia N.	1982	HBA1

Genes related to favism according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
2	HP	haptoglobin	11.0	Publications
3	ACP1	acid phosphatase 1, soluble	11.0	Publications
4	G6PC	glucose-6-phosphatase, catalytic subunit	11.0	Publications
5	HBA1	hemoglobin, alpha 1	11.0	Publications
6	CAT	catalase	11.0	Publications

Compounds related to favism according to GeneDecks:

(show top 50)    (show all 63)

id	Compound	Score	Top Affiliating Genes
1	n-ethylmaleimide32 9 9	12.5	G6PD
2	nadph32 18	11.3	G6PC
3	23-diphosphoglycerate32	10.0	G6PD, HP
4	zinc protoporphyrin32	9.9	G6PD, HP
5	sodium azide32	9.9	CAT, G6PD
6	citrate32	9.9	HP, CAT
7	dehydroascorbic acid32	9.8	CAT, G6PD
8	isoniazid32 34 9 9	12.8	CAT, G6PD
9	diamide32	9.8	ACP1, G6PD
10	6-phosphogluconate32	9.8	G6PD, ACP1
11	pentamidine32 9 9	11.8	G6PD, G6PC
12	aspartate32	9.8	HP, G6PC
13	tert-butylhydroperoxide32	9.7	G6PD, CAT
14	beta-hydroxybutyrate32	9.7	G6PC, HP
15	probucol32 9 9	11.7	HP, CAT
16	trolox32	9.7	ACP1, CAT
17	gssg32	9.7	CAT, G6PD
18	vanadium32	9.7	G6PC, ACP1
19	formate32	9.6	CAT, G6PD
20	mefloquine32 9 9	11.6	G6PD, HBA1
21	thiobarbituric acid32	9.5	CAT, HP, G6PD
22	tocopherol32	9.5	G6PD, HP, CAT
23	starch32	9.5	HP, ACP1, G6PD
24	cellulose acetate32	9.5	HP, ACP1, G6PD
25	con a32	9.5	HP, G6PC
26	vitamin-e32	9.5	G6PD, HP, CAT
27	alpha lipoic acid32	9.5	G6PD, ACP1, CAT
28	hypoxanthine32 9 18 9	12.4	CAT, ACP1, G6PD
29	diphenyleneiodonium32	9.4	G6PD, ACP1, CAT
30	salicylic acid32	9.4	G6PD, ACP1, CAT
31	sodium nitroprusside32	9.4	CAT, ACP1, G6PD
32	8-isoprostane32	9.4	CAT, HP
33	epinephrine32 9 18 9	12.3	HP, ACP1, G6PD
34	mannitol32 9 9	11.3	G6PD, G6PC, CAT
35	glycerol32 9 18 9	12.2	G6PD, G6PC, ACP1
36	copper32 18	10.2	CAT, HP, G6PC
37	dmso32	9.2	CAT, G6PC, G6PD
38	s-nitroso-n-acetylpenicillamine32	9.1	CAT, ACP1
39	nadh32 9 18 9	12.1	G6PD, G6PC, CAT
40	doxorubicin32 34 9 9	12.0	CAT, ACP1, G6PD
41	ascorbic acid32 18	10.0	G6PD, ACP1, HP, CAT
42	rapamycin32 42	9.9	G6PD, G6PC, ACP1
43	malondialdehyde32	8.9	CAT, HP, G6PC, G6PD
44	uric acid32 18	9.9	G6PD, G6PC, HP, CAT
45	glucose 6-phosphate32 18	9.9	CAT, HP, G6PC, G6PD
46	lactate32	8.9	G6PD, G6PC, HP, CAT
47	adenylate32	8.8	HP, ACP1, G6PC, G6PD
48	iron32 18	9.5	CAT, HP, G6PC, HBA1
49	h2o232	8.4	G6PD, G6PC, ACP1, HP, CAT
50	oxygen32 18	9.0	HBA1, G6PD, G6PC, ACP1, CAT

Cellular components related to favism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	internal side of plasma membrane	GO:009898	9.5	ACP1, G6PD

Biological processes related to favism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	triglyceride metabolic process	GO:006641	9.3	CAT, G6PC
2	glucose 6-phosphate metabolic process	GO:051156	9.1	G6PC, G6PD

Molecular functions related to favism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	NADP binding	GO:050661	9.5	CAT, G6PD