MCID: FVS001
MIFTS: 43

Favism malady

Summaries for Favism

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans.

MalaCards: Favism is related to thalassemia and methemoglobinemia. An important gene associated with Favism is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are FoxO family signaling and Folate Metabolism. The compounds 23-diphosphoglycerate and nadph have been mentioned in the context of this disorder. Affiliated tissues include whole blood, kidney and liver, and related mouse phenotype tumorigenesis.

Wikipedia:64 Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is an X-linked recessive hereditary... more...

Description from OMIM:47 134700

Aliases & Classifications for Favism

Sources:
8Disease Ontology, 9diseasecard, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

favism 8 9 22 47 10 45 61


External Ids:

Disease Ontology8 DOID:13628
MeSH35 D005236
NCIt40 C34607

Related Diseases for Favism

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Favism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1thalassemia30.3HBA1, G6PD
2methemoglobinemia30.0HP, G6PD
3beta thalassemia10.0
4noma10.0
5thalassemia minor10.0
6syncope10.0
7neonatal jaundice10.0G6PD
8blackwater fever10.0G6PD
9liver cirrhosis10.0HP
10obesity10.0ACP1
11viral hepatitis10.0G6PD
12polycythemia10.0G6PD
13microcytic anemia10.0G6PD
14leishmaniasis10.0ACP1
15iron deficiency anemia10.0G6PD
16nephrotic syndrome10.0HP
17hyperuricemia10.0G6PC
18sickle cell anemia10.0G6PD, HP
19congenital hemolytic anemia10.0G6PD, HP
20glucosephosphate dehydrogenase deficiency10.0G6PD, HP
21hemoglobinopathy10.0HP, G6PD
22paroxysmal nocturnal hemoglobinuria10.0HP, G6PD
23congenital hypothyroidism10.0G6PD
24sickle cell disease10.0HP, G6PD
25bilirubin metabolic disorder10.0HP, G6PD
26cerebral malaria10.0HP, G6PD
27meningitis10.0CAT
28plasmodium falciparum malaria10.0G6PD, HP
29keshan disease10.0GPX8, GPX6
30diabetic cataract10.0G6PD, CAT
31senile cataract10.0G6PD, CAT
32chronic granulomatous disease10.0G6PD, CAT
33malaria10.0ACP1, HP, G6PD
34hemolytic anemia10.0HP, G6PD
35hepatocellular carcinoma10.0ACP1, G6PC
36glioblastoma multiforme10.0ACP1, G6PC
37respiratory failure10.0G6PD, CAT
38alpha thalassemia10.0HBA1, G6PD
39insulin resistance10.0ACP1, G6PC
40acute kidney failure10.0CAT, G6PD, HP
41autoimmune hemolytic anemia10.0HP, G6PD
42pulmonary tuberculosis10.0ACP1, HP, CAT
43vascular disease10.0CAT, G6PD, HP
44hypertrophy of breast10.0ACP1, HP, G6PD
45metabolic syndrome x10.0ACP1, G6PD, G6PC
46wilson disease10.0G6PD, G6PC, CAT
47ischemia10.0HP, G6PC, CAT
48deficiency anemia10.0HP, HBA1, G6PD
49atherosclerosis10.0CAT, G6PD, HP, ACP1
50pre-eclampsia10.0HP, G6PC, CAT

Graphical network of the top 20 diseases related to Favism:



Diseases related to favism

Clinical Features for Favism

Sources:
47OMIM
See all sources

Clinical features from OMIM:

134700

Clinical synopsis from OMIM:

134700

Drugs & Therapeutics for Favism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Favism

Drug clinical trials:

Search ClinicalTrials for Favism

Search NIH Clinical Center for Favism

Search CenterWatch for Favism

Genetic Tests for Favism

Sources:
22GTR
See all sources

Genetic tests related to Favism:

id Genetic test Affiliating Genes
1 Favism, Susceptibility To22

Anatomical Context for Favism

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Favism:

33
Whole blood, Kidney, Liver, Breast, T cells

Animal Models for Favism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Favism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5GPX7, HP, G6PC, CAT

Publications for Favism

Sources:
51PubMed
See all sources

Articles related to Favism:

(show top 50)    (show all 156)
idTitleAuthorsYear
1
Oxidative stress and antioxidant defense in Egyptian favism patients. (23690191)
2013
2
Favism in a 15-month-old baby. (24312948)
2013
3
Acute renal failure in favism revealing familial glucose-6-phosphate dehydrogenase deficiency. (22279353)
2012
4
Molecular mediators of favism-induced acute kidney injury. (23006341)
2012
5
Molecular identification of mutations in G6PD gene in patients with favism in Iran. (15957246)
2004
6
Favism: effect of divicine on rat erythrocyte sulfhydryl status, hexose monophosphate shunt activity, morphology, and membrane skeletal proteins. (11452148)
2001
7
Favism]. (11155491)
2000
8
Favism: divicine hemotoxicity in the rat. (10543033)
1999
9
Favism by proxy in nursing glucose-6-phosphate dehydrogenase-deficient neonates. (9848766)
1998
10
Haptoglobin therapy for acute favism: a Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara. (7873396)
1995
11
Variation of favism-inducing factors (vicine, convicine and L-DOPA) during pod development in Vicia faba L. (7659704)
1995
12
Marked decline of favism after neonatal glucose-6-phosphate dehydrogenase screening and health education: the northern Sardinian experience. (1585769)
1992
13
Favism in the African type of glucose-6-phosphate dehydrogenase deficiency (A-). (2106932)
1990
14
Glucose-6-phosphate dehydrogenase (G6PD) deficiency in southern Italy: a case of G6PD A(-) associated with favism. (2498187)
1989
15
Favism: impairment of proteolytic systems in red blood cells. (3034353)
1987
16
Ahaptoglobinemia in Favism patients from Iran. (3870884)
1985
17
Favism in two British women. (2865483)
1985
18
The effects of isouramil on erythrocyte mechanics: implications for favism. (6546147)
1984
19
A novel method for quantitation of favism-inducing agents in legumes. (6846790)
1983
20
Effect of factors of favism on the protein and lipid components of rat erythrocyte membrane. (6849913)
1983
21
Mechanisms of red cell clearance in favism. (6675699)
1983
22
Favism--a natural model for the study of hemolytic mechanisms. (6760258)
1982
23
The chemistry of favism-inducing compounds. The properties of isouramil and divicine and their reaction with glutathione. (7140776)
1982
24
Heterogeneity of "Mediterranean type" glucose-6-phosphate dehydrogenase (G6PD) deficiency in Spain and description of two new variants associated with favism. (7106752)
1982
25
The pattern of bean consumption, laboratory findings in patients with favism, G-6-P-D deficient, and a control group. (7230311)
1981
26
Favism: erythrocyte metabolism during haemolysis and reticulocytosis. (41565)
1979
27
Tf, Gc and Cp phenotypes in favism and G-6-PD deficiency. (750450)
1978
28
The prelevance of immune reactions in acute favism. (4136243)
1974
29
Urinary D-glucaric acid excretion in normal and G-6-PD-deficient children with favism. (4826626)
1974
30
Favism in Singapore. (5051872)
1972
31
Abnormal glucose tolerance in favism. (5452391)
1970
32
Plasma magnesium during hemolytic crisis in children with favism. (5417236)
1970
33
Glucose-6-phosphate-dehydrogenase deficiency and favism. (4187209)
1969
34
Favism: clinical and biochemical data. (5771221)
1969
35
Favism in a 4-year-old boy. (5903167)
1966
36
THE MECHANISM OF HAEMOLYSIS IN FAVISM. SOME ANALOGY IN THE ACTIVITY OF PRIMAQUINE AND FAVA JUICE. (14326932)
1965
37
Favism in a white South African child. (13941936)
1963
38
Favism. (13886569)
1962
39
Studies on favism. 3. Studies on the physiological activites of vicine in vitro. (13930697)
1962
40
Favism: A Family Study [Abstract]. (19994164)
1962
41
Favism--report of a case. (14400102)
1959
42
Favism in Western Australia. (13589360)
1958
43
A case of favism. (14368862)
1955
44
Favism; a case report. (14365222)
1955
45
Favism; report of a case and brief review of the literature. (13053334)
1953
46
Favism in London. (13105385)
1953
47
Favism in Cyprus; analysis of 67 cases admitted to Nicosia General Hospital during the last 3 years. (14926361)
1952
48
Favism. (14887294)
1951
49
Favism in childhood; a case report. (14884561)
1951
50
Favism; a short review and report of a case. (20248434)
1947

Genetic Variations for Favism

Expression for genes affiliated with Favism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Favism

Search GEO for disease gene expression data for Favism.

Pathways for genes affiliated with Favism

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Favism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6G6PC, CAT
29.5GPX6, CAT
39.1CAT, HBA1, GPX6
48.5GPX6, GPX8, GPX7
5
Hide members
8.5GPX6, GPX7, GPX8
6
Hide members
8.5GPX6, GPX7, GPX8
7
Glutathione metabolism
Hide members
8.2G6PD, GPX8, GPX7, GPX6

Compounds for genes affiliated with Favism

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Favism according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
123-diphosphoglycerate4510.2HP, G6PD
2nadph45 2411.2G6PD, G6PC
3zinc protoporphyrin4510.1G6PD, HP
4pentamidine45 1111.1G6PC, G6PD
5mefloquine45 1111.1G6PD, HBA1
6oxygen45 2411.1G6PC, HBA1
7beta-hydroxybutyrate4510.1G6PC, HP
8sodium azide4510.0G6PD, CAT
9dehydroascorbic acid45 1111.0G6PD, CAT
10vanadium4510.0ACP1, G6PC
11isoniazid50 45 1111.9G6PD, CAT
12probucol45 1110.9CAT, HP
13diamide459.9ACP1, G6PD
14tert-butylhydroperoxide459.8G6PD, CAT
156-phosphogluconate459.8G6PD, ACP1
16thiobarbituric acid459.8HP, G6PD, CAT
17tocopherol459.8CAT, G6PD, HP
18glucose 6-phosphate45 2410.8G6PD, G6PC, CAT
19gssg459.8CAT, G6PD
20vitamin-e459.8CAT, G6PD, HP
21con a459.8HP, G6PC
22trolox459.8ACP1, CAT
23starch459.7ACP1, HP, G6PD
24cellulose acetate459.7ACP1, HP, G6PD
25citrate459.7HP, G6PD, CAT
26mannitol45 1110.7G6PD, G6PC, CAT
278-isoprostane459.7HP, CAT
28alpha lipoic acid459.6ACP1, G6PD, CAT
29hypoxanthine45 11 2411.6ACP1, G6PD, CAT
30copper45 2410.6CAT, G6PC, HP
31diphenyleneiodonium459.6ACP1, G6PD, CAT
32formate459.6G6PD, CAT
33dmso459.6CAT, G6PC, G6PD
34salicylic acid45 2910.6ACP1, G6PD, CAT
35n-ethylmaleimide45 1110.6ACP1, G6PD, CAT
36sodium nitroprusside459.6CAT, G6PD, ACP1
37glycerol45 11 2411.5ACP1, G6PD, G6PC
385-hpete45 2410.5GPX6, GPX7
39sulfasalazine45 29 50 1112.5HP, G6PD
40malondialdehyde459.4HP, G6PD, G6PC, CAT
41uric acid45 2410.4CAT, G6PC, G6PD, HP
42epinephrine45 11 2411.4ACP1, HP, G6PD
43lactate459.4CAT, G6PC, G6PD, HP
44iron45 2410.3HP, HBA1, G6PC, CAT
45aspartate459.3G6PC, G6PD, HP, ACP1
46ascorbic acid45 2410.3CAT, G6PD, HP, ACP1
47adenylate459.2G6PC, G6PD, HP, ACP1
48selenium45 2410.1GPX6, GPX7, CAT
49Glutathione11 249.9GPX8, GPX7, GPX6
50h2o2458.9CAT, G6PC, G6PD, HP, ACP1

GO Terms for genes affiliated with Favism

Sources:
16Gene Ontology
See all sources

Cellular components related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1internal side of plasma membraneGO:0098989.6ACP1, G6PD

Biological processes related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1triglyceride metabolic processGO:0066419.6G6PC, CAT
2glucose 6-phosphate metabolic processGO:0511569.5G6PD, G6PC
3response to oxidative stressGO:0069798.4GPX6, GPX7, GPX8

Molecular functions related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:0506619.7G6PD, CAT
2antioxidant activityGO:0162099.4HP, CAT
3glutathione peroxidase activityGO:0046028.4GPX6, GPX7, GPX8

Products for genes affiliated with Favism

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Favism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet