Summaries for Favism

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OMIM:46 Hemolytic anemia following ingestion of the bean of Vicia faba or exposure to its pollen is conditioned primarily by a...134700 more...

MalaCards based summary: Favism is related to hemolytic anemia and glucosephosphate dehydrogenase deficiency, and has symptoms including autosomal dominant inheritanceand fava bean-induced hemolytic anemia. An important gene associated with Favism is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and FoxO family signaling. The compounds 23-diphosphoglycerate and zinc protoporphyrin have been mentioned in the context of this disorder. Affiliated tissues include kidney, breast and liver, and related mouse phenotype mortality/aging.

Disease Ontology:9 A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans.

Wikipedia:64 Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) also known as favism (after the fava... more...

Aliases & Classifications for Favism

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Sources:
9Disease Ontology, 10diseasecard, 23GTR, 46OMIM, 11DISEASES, 44Novoseek, 61UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
See all sources

Favism, Aliases & Descriptions:

Name: Favism 9 10 23 46 11 44 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology9 DOID:13628
MeSH34 D005236
NCIt39 C34607

Related Diseases for Favism

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Diseases related to Favism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1hemolytic anemia30.6HP, G6PD
2glucosephosphate dehydrogenase deficiency30.4HP, G6PD
3methemoglobinemia30.4HP, G6PD
4malaria30.1ACP1, HP, G6PD
5blackwater fever10.5G6PD
6thalassemia10.3
7congenital hemolytic anemia10.2G6PD, HP
8hemoglobinuria10.2HP, G6PD
9hemoglobinopathy10.2HP, G6PD
10diabetic cataract10.2CAT, G6PD
11senile cataract10.2CAT, G6PD
12autoimmune hemolytic anemia10.2HP, G6PD
13paroxysmal nocturnal hemoglobinuria, somatic10.2G6PD, HP
14bilirubin metabolic disorder10.2HP, G6PD
15cerebral malaria10.2HP, G6PD
16chronic granulomatous disease10.2G6PD, CAT
17polycythemia vera10.2G6PD, ACP1
18plasmodium falciparum malaria10.2HP, G6PD
19tuberculosis10.2HP, ACP1
20respiratory failure10.2G6PD, CAT
21vitiligo10.1CAT, G6PD
22sickle cell disease10.1HP, G6PD
23rheumatoid arthritis10.1HP, ACP1
24alpha thalassemia10.1HBA1, G6PD
25cataract10.1CAT, G6PD
26galactosemia10.0CAT, HP
27beta thalassemia10.0
28syncope10.0
29acute kidney failure10.0G6PD, CAT, HP
30diabetic nephropathy10.0CAT, HP
31pulmonary tuberculosis10.0HP, CAT, ACP1
32vascular disease10.0HP, CAT, G6PD
33metabolic syndrome x10.0G6PD, ACP1, G6PC
34wilson disease10.0CAT, G6PD, G6PC
35congenital heart disease9.9HP, ACP1
36pre-eclampsia9.9HP, G6PC, CAT
37kidney cancer9.9HP, ACP1, G6PC
38primary hyperoxaluria9.9CAT, G6PC, HP
39deficiency anemia9.9HBA1, G6PD, HP
40ischemia9.8HP, G6PC, CAT
41atherosclerosis9.8CAT, G6PD, HP, ACP1
42hypoglycemia9.8G6PC, HBA1
43malignant glioma9.8ACP1, G6PD, G6PC, CAT
44hyperglycemia9.6CAT, HBA1, ACP1, G6PC
45type 2 diabetes mellitus9.6ACP1, HBA1, G6PC, CAT
46diabetes mellitus9.2G6PC, HBA1, G6PD, ACP1, HP, CAT

Graphical network of the top 20 diseases related to Favism:



Diseases related to favism

Symptoms for Favism

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Symptoms by clinical synopsis from OMIM:

134700

Clinical features from OMIM:

134700

HPO human phenotypes related to Favism:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 fava bean-induced hemolytic anemia HP:0004814

Drugs & Therapeutics for Favism

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Drug clinical trials:

Search ClinicalTrials for Favism

Search NIH Clinical Center for Favism

Genetic Tests for Favism

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Genetic tests related to Favism:

id Genetic test Affiliating Genes
1 Favism, Susceptibility to23

Anatomical Context for Favism

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MalaCards organs/tissues related to Favism:

32
Kidney, Breast, Liver

Animal Models for Favism or affiliated genes

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MGI Mouse Phenotypes related to Favism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.6CAT, HP, G6PD, G6PC, HBA1

Publications for Favism

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Articles related to Favism:

(show top 50)    (show all 156)
idTitleAuthorsYear
1
Acute Favism: Methemoglobinemia May Cause Cyanosis and Low Pulse Oximetry Readings. (23697341)
2013
2
Do favic patients resume fava beans ingestion later in their life, a study for this, and a new hypothesis for favism etiology. (23664599)
2013
3
Evaluation of liver and kidney function in favism patients. (23483616)
2013
4
Favism: effect of divicine on rat erythrocyte sulfhydryl status, hexose monophosphate shunt activity, morphology, and membrane skeletal proteins. (11452148)
2001
5
Favism: divicine hemotoxicity in the rat. (10543033)
1999
6
Active involvement of catalase during hemolytic crises of favism. (8704218)
1996
7
Haptoglobin therapy for acute favism: a Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara. (7873396)
1995
8
Variation of favism-inducing factors (vicine, convicine and L-DOPA) during pod development in Vicia faba L. (7659704)
1995
9
Mechanisms of perturbation of erythrocyte calcium homeostasis in favism. (1337501)
1992
10
Recent advances in the biochemistry of favism. (2201290)
1990
11
Glucose-6-phosphate dehydrogenase (G6PD) deficiency in southern Italy: a case of G6PD A(-) associated with favism. (2498187)
1989
12
Desferrioxamine and favism. (3718878)
1986
13
Favism: disordered erythrocyte calcium homeostasis. (2410063)
1985
14
Deferoxamine and favism. (3990722)
1985
15
Biological activities of broad bean (Vicia faba L.) extracts cultivated in South Anatolia in favism sensitive subjects. (6740693)
1984
16
Lymphocyte changes in favism: in vitro evidence of a modifying effect of bilirubin and hemoglobin on T-lymphocyte receptors. (6402878)
1983
17
Hemoglobin A1 in subjects with G-6-PD deficiency during and after hemolytic crises due to favism. (6401888)
1983
18
A novel method for quantitation of favism-inducing agents in legumes. (6846790)
1983
19
Favism and hemolytic anemia in glucose-6-phosphate dehydrogenase-deficient subjects in North Sardinia. (6408883)
1983
20
Favism--a natural model for the study of hemolytic mechanisms. (6760258)
1982
21
The chemistry of favism-inducing compounds. The properties of isouramil and divicine and their reaction with glutathione. (7140776)
1982
22
Effect of divicine and isouramil on red cell metabolism in normal and G6PD-deficient (Mediterranean variant) subjects. Possible role in the genesis of favism. (7291203)
1981
23
Favism in GdMediterranean heterozygous females. (481952)
1979
24
Malaria, favism and glucose-6-phosphate dehydrogenase deficiency. (1107056)
1975
25
A serum defect in favism. (4816791)
1974
26
Serum concentrations of haptoglobin and hemopexin in favism and thalassemia. (4214606)
1974
27
Investigations on favism-inducing toxins in broad beans (Vicia faba L.). (4794968)
1973
28
The epidemiology of favism. (4541143)
1973
29
Biochemical characterization of a glucose-6-phosphate dehydrogenase variant with favism: G-6-PD ZAohringen. (5011553)
1972
30
Favism in Singapore. (5051872)
1972
31
On the pathogenesis of favism. (5149530)
1971
32
Favism in breast-fed infants. (5555486)
1971
33
Some clinical and biochemical aspects of favism in childhood. (5351939)
1969
34
Glucose-6-phosphate-dehydrogenase deficiency and favism. (4187209)
1969
35
The oxidant effect of isouramil on red cell glutathione and its synergistic enhancement by ascorbic acid or 3,4-dihydroxyphenylalanine. Possible relation to the pathogenesis of favism. (5707783)
1968
36
On the familial predisposition to favism. (5944419)
1966
37
Favism in Britain. (5833616)
1965
38
FAVISM IN ENGLAND--TWO MORE CASES. (14294749)
1965
39
Favism in a white South African child. (13941936)
1963
40
Studies on favism. I. Isolation of an active principle from faba beans (Vicia faba). (13930699)
1962
41
Favism. (20326465)
1960
42
Favism in a Cypriot child. (13828644)
1960
43
Favism--report of a case. (14400102)
1959
44
Nature of favism; case presentation]. (13211128)
1954
45
Favism; report of a case and brief review of the literature. (13053334)
1953
46
Favism in Cyprus; analysis of 67 cases admitted to Nicosia General Hospital during the last 3 years. (14926361)
1952
47
Favism. (14887294)
1951
48
Favism in childhood; a case report. (14884561)
1951
49
Favism in Israel. (14888076)
1951
50
Favism. (18879460)
1948

Variations for Favism

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Expression for genes affiliated with Favism

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Expression patterns in normal tissues for genes affiliated with Favism

Search GEO for disease gene expression data for Favism.

Pathways for genes affiliated with Favism

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Pathways related to Favism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4HP, HBA1
29.1CAT, G6PC
3
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.1CAT, G6PC
4
Show member pathways
thioredoxin pathway37
9.0CAT, HBA1
5
Show member pathways
8.1HBA1, G6PC, G6PD, CAT

Compounds for genes affiliated with Favism

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Sources:
44Novoseek, 50PharmGKB, 12DrugBank, 25HMDB, 29IUPHAR
See all sources

Compounds related to Favism according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
123-diphosphoglycerate4410.0G6PD, HP
2zinc protoporphyrin449.9G6PD, HP
3dimercaprol44 5010.9ACP1, G6PD
4pentamidine44 1210.9G6PC, G6PD
5beta-hydroxybutyrate449.8G6PC, HP
6diamide449.8ACP1, G6PD
7vanadium449.8G6PC, ACP1
8mefloquine44 50 1211.8HBA1, G6PD
96-phosphogluconate449.8G6PD, ACP1
10sodium azide449.5CAT, G6PD
11dehydroascorbic acid44 1210.5G6PD, CAT
12starch449.5HP, ACP1, G6PD
13cellulose acetate449.5G6PD, ACP1, HP
14con a449.5HP, G6PC
15isoniazid44 50 1211.5G6PD, CAT
16trolox449.4ACP1, CAT
17probucol44 1210.4HP, CAT
18tert-butylhydroperoxide449.4G6PD, CAT
19glycerol44 25 1211.4ACP1, G6PD, G6PC
20epinephrine44 25 1211.4HP, ACP1, G6PD
21gssg449.3G6PD, CAT
22thiobarbituric acid449.2G6PD, HP, CAT
23tocopherol449.2CAT, HP, G6PD
24vitamin-e449.2CAT, HP, G6PD
25citrate449.2CAT, HP, G6PD
26alpha lipoic acid449.2G6PD, ACP1, CAT
27hypoxanthine44 25 1211.1CAT, ACP1, G6PD
28diphenyleneiodonium449.1G6PD, ACP1, CAT
29salicylic acid44 2910.1CAT, ACP1, G6PD
30rapamycin449.1ACP1, G6PD, G6PC
31n-ethylmaleimide44 1210.1G6PD, ACP1, CAT
32sodium nitroprusside449.1CAT, ACP1, G6PD
33mannitol44 1210.1G6PC, G6PD, CAT
34dmso449.1G6PC, G6PD, CAT
35copper44 2510.0CAT, HP, G6PC
36aspartate449.0HP, ACP1, G6PD, G6PC
37adenylate449.0G6PC, G6PD, ACP1, HP
38nadh44 25 1210.9CAT, G6PD, G6PC
39doxorubicin44 50 1210.7CAT, ACP1, G6PD
40malondialdehyde448.7CAT, HP, G6PD, G6PC
41uric acid44 259.7CAT, HP, G6PD, G6PC
42glucose 6-phosphate44 259.7CAT, HP, G6PD, G6PC
43ascorbic acid44 259.7CAT, HP, ACP1, G6PD
44lactate448.7G6PC, G6PD, HP, CAT
45nadph44 259.6G6PC, G6PD, ACP1, CAT
46actinomycin d448.5CAT, HP, G6PD
47iron44 259.5HBA1, G6PC, HP, CAT
48h2o2448.2G6PC, G6PD, ACP1, HP, CAT
49lipid448.2G6PC, G6PD, HP, CAT
50oxygen44 259.0HBA1, G6PC, G6PD, ACP1, CAT

GO Terms for genes affiliated with Favism

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Cellular components related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:0098989.5ACP1, G6PD

Biological processes related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose 6-phosphate metabolic processGO:0511569.2G6PD, G6PC
2triglyceride metabolic processGO:0066419.1CAT, G6PC

Molecular functions related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:0506619.2CAT, G6PD
2antioxidant activityGO:0162098.9CAT, HP

Products for genes affiliated with Favism

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Sources for Favism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet