Summaries for Favism

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8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
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Fully expand this MalaCard
Disease Ontology:8 A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans.

MalaCards: Favism is related to glucosephosphate dehydrogenase deficiency and hemolytic anemia. An important gene associated with Favism is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and FoxO family signaling. The compounds 23-diphosphoglycerate and zinc protoporphyrin have been mentioned in the context of this disorder. Affiliated tissues include kidney, breast and liver, and related mouse phenotype mortality/aging.

Wikipedia:65 Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is an X-linked recessive hereditary... more...

Description from OMIM:47 134700

Aliases & Classifications for Favism

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8Disease Ontology, 9diseasecard, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Aliases & Descriptions:

favism 8 9 22 47 10 45 62


External Ids:

Disease Ontology8 DOID:13628
MeSH35 D005236
NCIt40 C34607

Related Diseases for Favism

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Favism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1glucosephosphate dehydrogenase deficiency30.5G6PD, HP
2hemolytic anemia30.4HP, G6PD
3methemoglobinemia30.1G6PD, HP
4malaria30.0G6PD, ACP1, HP
5thalassemia10.3
6blackwater fever10.1G6PD
7sickle cell anemia10.1G6PD, HP
8congenital hemolytic anemia10.1G6PD, HP
9hemoglobinuria10.1HP, G6PD
10hemoglobinopathy10.1G6PD, HP
11diabetic cataract10.1CAT, G6PD
12senile cataract10.1G6PD, CAT
13autoimmune hemolytic anemia10.0G6PD, HP
14paroxysmal nocturnal hemoglobinuria10.0HP, G6PD
15bilirubin metabolic disorder10.0HP, G6PD
16chronic granulomatous disease10.0CAT, G6PD
17cerebral malaria10.0HP, G6PD
18polycythemia vera10.0ACP1, G6PD
19plasmodium falciparum malaria10.0HP, G6PD
20tuberculosis10.0ACP1, HP
21respiratory failure10.0CAT, G6PD
22vitiligo10.0CAT, G6PD
23sickle cell disease10.0HP, G6PD
24beta thalassemia10.0
25syncope10.0
26rheumatoid arthritis10.0HP, ACP1
27alpha thalassemia10.0G6PD, HBA1
28cataract10.0G6PD, CAT
29galactosemia10.0HP, CAT
30acute kidney failure10.0CAT, HP, G6PD
31diabetic nephropathy10.0CAT, HP
32pulmonary tuberculosis10.0ACP1, HP, CAT
33vascular disease10.0G6PD, HP, CAT
34hypertrophy of breast10.0G6PD, ACP1, HP
35metabolic syndrome x10.0ACP1, G6PD, G6PC
36wilson disease10.0G6PC, G6PD, CAT
37congenital heart disease10.0HP, ACP1
38pre-eclampsia10.0CAT, HP, G6PC
39kidney cancer10.0G6PC, ACP1, HP
40deficiency anemia10.0HP, G6PD, HBA1
41primary hyperoxaluria10.0G6PC, HP, CAT
42ischemia10.0G6PC, HP, CAT
43atherosclerosis10.0CAT, HP, ACP1, G6PD
44hypoglycemia9.9G6PC, HBA1
45malignant glioma9.9G6PC, G6PD, ACP1, CAT
46hyperglycemia9.9CAT, ACP1, G6PC, HBA1
47type 2 diabetes mellitus9.9HBA1, G6PC, ACP1, CAT
48diabetes mellitus9.8HBA1, G6PC, G6PD, ACP1, HP, CAT

Graphical network of the top 20 diseases related to Favism:



Diseases related to favism

Symptoms for Favism

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47OMIM
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Symptoms by clinical synopsis from OMIM:

134700

Clinical features from OMIM:

134700

Drugs & Therapeutics for Favism

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Favism

Search NIH Clinical Center for Favism

Genetic Tests for Favism

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22GTR
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Genetic tests related to Favism:

id Genetic test Affiliating Genes
1 Favism, Susceptibility to22

Anatomical Context for Favism

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33MalaCards
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MalaCards organs/tissues related to Favism:

33
Kidney, Breast, Liver

Animal Models for Favism or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Favism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.6CAT, HP, G6PD, G6PC, HBA1

Publications for Favism

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52PubMed
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Articles related to Favism:

(show top 50)    (show all 156)
idTitleAuthorsYear
1
Acute Favism: Methemoglobinemia May Cause Cyanosis and Low Pulse Oximetry Readings. (23697341)
2013
2
Do favic patients resume fava beans ingestion later in their life, a study for this, and a new hypothesis for favism etiology. (23664599)
2013
3
Evaluation of liver and kidney function in favism patients. (23483616)
2013
4
Favism: effect of divicine on rat erythrocyte sulfhydryl status, hexose monophosphate shunt activity, morphology, and membrane skeletal proteins. (11452148)
2001
5
Favism: divicine hemotoxicity in the rat. (10543033)
1999
6
Active involvement of catalase during hemolytic crises of favism. (8704218)
1996
7
Haptoglobin therapy for acute favism: a Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara. (7873396)
1995
8
Variation of favism-inducing factors (vicine, convicine and L-DOPA) during pod development in Vicia faba L. (7659704)
1995
9
Mechanisms of perturbation of erythrocyte calcium homeostasis in favism. (1337501)
1992
10
Recent advances in the biochemistry of favism. (2201290)
1990
11
Glucose-6-phosphate dehydrogenase (G6PD) deficiency in southern Italy: a case of G6PD A(-) associated with favism. (2498187)
1989
12
Pathophysiology of favism. (2481620)
1989
13
Desferrioxamine and favism. (3718878)
1986
14
Favism: disordered erythrocyte calcium homeostasis. (2410063)
1985
15
Deferoxamine and favism. (3990722)
1985
16
Biological activities of broad bean (Vicia faba L.) extracts cultivated in South Anatolia in favism sensitive subjects. (6740693)
1984
17
Lymphocyte changes in favism: in vitro evidence of a modifying effect of bilirubin and hemoglobin on T-lymphocyte receptors. (6402878)
1983
18
Hemoglobin A1 in subjects with G-6-PD deficiency during and after hemolytic crises due to favism. (6401888)
1983
19
A novel method for quantitation of favism-inducing agents in legumes. (6846790)
1983
20
Favism and hemolytic anemia in glucose-6-phosphate dehydrogenase-deficient subjects in North Sardinia. (6408883)
1983
21
Favism--a natural model for the study of hemolytic mechanisms. (6760258)
1982
22
The chemistry of favism-inducing compounds. The properties of isouramil and divicine and their reaction with glutathione. (7140776)
1982
23
Effect of divicine and isouramil on red cell metabolism in normal and G6PD-deficient (Mediterranean variant) subjects. Possible role in the genesis of favism. (7291203)
1981
24
Favism in GdMediterranean heterozygous females. (481952)
1979
25
Malaria, favism and glucose-6-phosphate dehydrogenase deficiency. (1107056)
1975
26
A serum defect in favism. (4816791)
1974
27
Serum concentrations of haptoglobin and hemopexin in favism and thalassemia. (4214606)
1974
28
Investigations on favism-inducing toxins in broad beans (Vicia faba L.). (4794968)
1973
29
The epidemiology of favism. (4541143)
1973
30
Biochemical characterization of a glucose-6-phosphate dehydrogenase variant with favism: G-6-PD ZAohringen. (5011553)
1972
31
Favism in Singapore. (5051872)
1972
32
On the pathogenesis of favism. (5149530)
1971
33
Favism in breast-fed infants. (5555486)
1971
34
Some clinical and biochemical aspects of favism in childhood. (5351939)
1969
35
Glucose-6-phosphate-dehydrogenase deficiency and favism. (4187209)
1969
36
The oxidant effect of isouramil on red cell glutathione and its synergistic enhancement by ascorbic acid or 3,4-dihydroxyphenylalanine. Possible relation to the pathogenesis of favism. (5707783)
1968
37
On the familial predisposition to favism. (5944419)
1966
38
Favism in Britain. (5833616)
1965
39
FAVISM IN ENGLAND--TWO MORE CASES. (14294749)
1965
40
Favism in a white South African child. (13941936)
1963
41
Studies on favism. I. Isolation of an active principle from faba beans (Vicia faba). (13930699)
1962
42
Favism. (20326465)
1960
43
Favism in a Cypriot child. (13828644)
1960
44
Favism--report of a case. (14400102)
1959
45
Nature of favism; case presentation]. (13211128)
1954
46
Favism in Cyprus; analysis of 67 cases admitted to Nicosia General Hospital during the last 3 years. (14926361)
1952
47
Favism. (14887294)
1951
48
Favism in childhood; a case report. (14884561)
1951
49
Favism in Israel. (14888076)
1951
50
Favism. (18879460)
1948

Variations for Favism

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Expression for genes affiliated with Favism

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Favism

Search GEO for disease gene expression data for Favism.

Pathways for genes affiliated with Favism

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Favism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4HP, HBA1
29.1CAT, G6PC
3
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.1CAT, G6PC
4
Show member pathways
thioredoxin pathway38
9.0CAT, HBA1
5
Show member pathways
8.1HBA1, G6PC, G6PD, CAT

Compounds for genes affiliated with Favism

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45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR
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Compounds related to Favism according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
123-diphosphoglycerate4510.0G6PD, HP
2zinc protoporphyrin459.9G6PD, HP
3dimercaprol45 5110.9ACP1, G6PD
4pentamidine45 1110.9G6PC, G6PD
5beta-hydroxybutyrate459.8G6PC, HP
6diamide459.8ACP1, G6PD
7vanadium459.8G6PC, ACP1
8mefloquine45 51 1111.8HBA1, G6PD
96-phosphogluconate459.8G6PD, ACP1
10sodium azide459.5CAT, G6PD
11dehydroascorbic acid45 1110.5G6PD, CAT
12starch459.5HP, ACP1, G6PD
13cellulose acetate459.5G6PD, ACP1, HP
14con a459.5HP, G6PC
15isoniazid45 51 1111.5G6PD, CAT
16trolox459.4ACP1, CAT
17probucol45 1110.4HP, CAT
18tert-butylhydroperoxide459.4G6PD, CAT
19glycerol45 24 1111.4ACP1, G6PD, G6PC
20epinephrine45 24 1111.4HP, ACP1, G6PD
21gssg459.3G6PD, CAT
22thiobarbituric acid459.2G6PD, HP, CAT
23tocopherol459.2CAT, HP, G6PD
24vitamin-e459.2CAT, HP, G6PD
25citrate459.2CAT, HP, G6PD
26alpha lipoic acid459.2G6PD, ACP1, CAT
27hypoxanthine45 24 1111.1CAT, ACP1, G6PD
28diphenyleneiodonium459.1G6PD, ACP1, CAT
29salicylic acid45 2910.1CAT, ACP1, G6PD
30rapamycin459.1ACP1, G6PD, G6PC
31n-ethylmaleimide45 1110.1G6PD, ACP1, CAT
32sodium nitroprusside459.1CAT, ACP1, G6PD
33mannitol45 1110.1G6PC, G6PD, CAT
34dmso459.1G6PC, G6PD, CAT
35copper45 2410.0CAT, HP, G6PC
36aspartate459.0HP, ACP1, G6PD, G6PC
37adenylate459.0G6PC, G6PD, ACP1, HP
38nadh45 24 1110.9CAT, G6PD, G6PC
39doxorubicin45 51 1110.7CAT, ACP1, G6PD
40malondialdehyde458.7CAT, HP, G6PD, G6PC
41uric acid45 249.7CAT, HP, G6PD, G6PC
42glucose 6-phosphate45 249.7CAT, HP, G6PD, G6PC
43ascorbic acid45 249.7CAT, HP, ACP1, G6PD
44lactate458.7G6PC, G6PD, HP, CAT
45nadph45 249.6G6PC, G6PD, ACP1, CAT
46actinomycin d458.5CAT, HP, G6PD
47iron45 249.5HBA1, G6PC, HP, CAT
48h2o2458.2G6PC, G6PD, ACP1, HP, CAT
49lipid458.2G6PC, G6PD, HP, CAT
50oxygen45 249.0HBA1, G6PC, G6PD, ACP1, CAT

GO Terms for genes affiliated with Favism

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16Gene Ontology
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Cellular components related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:0098989.5ACP1, G6PD

Biological processes related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose 6-phosphate metabolic processGO:0511569.2G6PD, G6PC
2triglyceride metabolic processGO:0066419.1CAT, G6PC

Molecular functions related to Favism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:0506619.2CAT, G6PD
2antioxidant activityGO:0162098.9CAT, HP

Products for genes affiliated with Favism

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  • Antibodies
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Sources for Favism

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet