MCID: FBR031
MIFTS: 48

Febrile Seizures malady

Summaries for Febrile Seizures

Sources:
44NINDS, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NINDS:44 Febrile seizures are convulsions brought on by a fever in infants or small children. During a febrile seizure, a child often loses consciousness and shakes.

MalaCards: Febrile Seizures, also known as febrile convulsions, is related to dravet syndrome and generalized epilepsy with febrile seizures plus. An important gene associated with Febrile Seizures is GABRG2 (gamma-aminobutyric acid (GABA) A receptor, gamma 2), and among its related pathways are Circadian entrainment and Synaptic transmission: ion currents. The drugs phenobarbital and phenobarbital sodium and the compounds Cinolazepam and Halazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and t cells, and related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Febrile Seizures

Sources:
44NINDS, 45Novoseek, 61UMLS, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

febrile seizures 44
febrile convulsions 61
seizures febrile 45


External Ids:

ICD1025 R56.0

Related Diseases for Febrile Seizures

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the familial febrile seizures 3b family:

febrile seizures febrile seizures, familial, 3a
febrile seizures, familial, 9 febrile seizures, familial, 10
febrile seizures, familial, 4 febrile seizures, familial, 8
febrile seizures, familial, 5 febrile seizures, familial, 11
febrile seizures, familial, 1 febrile seizures, familial, 6
febrile seizures, familial, 2 febrile seizures, familial, 7

Diseases related to Febrile Seizures via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1dravet syndrome30.8SCN1A, SCN8A, GABRD, SCN1B, GABRG2
2generalized epilepsy with febrile seizures plus30.5SCN1B
3brugada syndrome30.0SCN8A, SCN1B
4temporal lobe epilepsy10.6
5familial febrile seizures 3b10.5
6epilepsy, generalized, with febrile seizures plus, type 110.5
7epilepsy, generalized, with febrile seizures plus, type 310.5
8seizure disorder10.4
9epilepsy, generalized, with febrile seizures plus, type 210.4
10measles10.3
11epilepsy, generalized, with febrile seizures plus, type 510.3
12deficiency anemia10.2
13rubella10.2
14childhood absence epilepsy10.2
15iron deficiency anemia10.2
16mumps10.2
17temporal epilepsy, familial10.2
18mental retardation, keratoconus, febrile seizures, and sinoatrial block10.2
19scn1b-related generalized epilepsy with febrile seizures plus10.2
20gabrg2-related generalized epilepsy with febrile seizures plus10.2
21scn9a-related generalized epilepsy with febrile seizures plus10.2
22scn1a- related generalized epilepsy with febrile seizures plus10.2
23febrile seizures, familial, 1110.2
24febrile seizures, familial, 110.2
25febrile seizures, familial, 210.2
26attention deficit hyperactivity disorder10.2
27status epilepticus10.2
28bacterial meningitis10.2
29gabrd-related generalized epilepsy with febrile seizures plus10.2
30scn1a-related simple febrile seizures10.2
31epilepsy, generalized, with febrile seizures plus, type 410.2
32febrile seizures, familial, 3a10.2
33epilepsy, generalized, with febrile seizures plus, type 710.2
34febrile seizures, familial, 910.2
35febrile seizures, familial, 1010.2
36febrile seizures, familial, 410.2
37febrile seizures, familial, 810.2
38epilespy, generalized, with febrile seizures plus, type 810.2
39febrile seizures, familial, 510.2
40epilepsy, generalized, with febrile seizures plus, type 610.2
41febrile seizures, familial, 610.2
42febrile seizures, familial, 710.2
43exanthema subitum10.1
44ataxia10.1
45encephalopathy, acute, infection-induced, 410.1
46audiogenic seizures10.1
47diphtheria10.0
48familial hemiplegic migraine10.0
49periodic limb movement disorder10.0
50celiac disease10.0

Graphical network of the top 20 diseases related to Febrile Seizures:



Diseases related to febrile seizures

Clinical Features for Febrile Seizures

Drugs & Therapeutics for Febrile Seizures

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Febrile Seizures

Drug clinical trials:

Search ClinicalTrials for Febrile Seizures

Search NIH Clinical Center for Febrile Seizures

Search CenterWatch for Febrile Seizures

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Febrile Seizures

Anatomical Context for Febrile Seizures

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Febrile Seizures:

33
Brain, Cortex, T cells, B cells, Fetal brain, Temporal lobe

Animal Models for Febrile Seizures or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Febrile Seizures:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.1ICAM5, SCN1B, SCN8A, SCN9A, SCN1A, GABRD
2MP:00053869.8GPR98, KCNQ2, ICAM5, SCN1B, SCN8A, SCN9A

Publications for Febrile Seizures

Sources:
51PubMed
See all sources

Articles related to Febrile Seizures:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
Genetic background of febrile seizures. (24399675)
2014
2
Prognostic factors for subsequent epilepsy in children with febrile seizures. (24304433)
2013
3
Maternal use of antibiotics and the risk of childhood febrile seizures: a Danish population-based cohort. (23613800)
2013
4
Febrile seizures in rural Tanzania: hospital-based incidence and clinical characteristics. (23619600)
2013
5
"Simple febrile seizures plus (SFS+)": more than one febrile seizure within 24 hours is usually okay. (23624109)
2013
6
Facial emotion recognition in childhood: the effects of febrile seizures in the developing brain. (23994831)
2013
7
Prolonged febrile seizures cause reversible reductions in white matter integrity. (24273734)
2013
8
Fishing for the mechanisms causing febrile seizures: employing a novel model to uncover the physiological generators of seizures with fever. (23178581)
2013
9
Measles-containing vaccines and febrile seizures in children age 4 to 6 years. (22473362)
2012
10
GABRG2 gene polymorphisms in Egyptian children with simple febrile seizures. (21983990)
2012
11
Validation of reference genes for quantitative real-time PCR studies in the dentate gyrus after experimental febrile seizures. (23237195)
2012
12
Mosaic SCN1A mutations in familial partial epilepsy with antecedent febrile seizures. (22151702)
2012
13
Failure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis. (22578703)
2012
14
Experimental early-life febrile seizures induce changes in GABA(A) R-mediated neurotransmission in the dentate gyrus. (23030508)
2012
15
Restless leg syndrome, periodic limb movements, febrile seizures and Attention deficit hyperactivity disorder in an Indian family. (22412272)
2012
16
Top 10 facts you need to know about febrile seizures. (22372159)
2011
17
Epileptogenesis after prolonged febrile seizures: mechanisms, biomarkers and therapeutic opportunities. (21356275)
2011
18
Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures. (21989210)
2011
19
Academic and social success in adolescents with previous febrile seizures. (21269845)
2011
20
Febrile seizures are a syndrome of secondarily generalized hippocampal epilepsy. (20722664)
2010
21
Novel mutation of SCN1A in familial generalized epilepsy with febrile seizures plus. (20600615)
2010
22
Febrile seizures: four steps algorithmic clinical approach. (23056677)
2010
23
Febrile seizures - semiology in humans and animal models: evidence of focality and heterogeneity. (19836910)
2010
24
Seizure susceptibility due to antihistamines in febrile seizures. (20837317)
2010
25
Long-lasting modulation of synaptic plasticity in rat hippocampus after early-life complex febrile seizures. (20646062)
2010
26
Prenatal stress and risk of febrile seizures in children: a nationwide longitudinal study in Denmark. (19291382)
2009
27
Advice for patients. Febrile seizures in children. (19736347)
2009
28
Progress in molecular genetics of generalized epilepsy with febrile seizures plus]. (18458705)
2008
29
Nitric oxide-mediated neuronal apoptosis in rats with recurrent febrile seizures through endoplasmic reticulum stress pathway. (18675883)
2008
30
Upregulated H-current in hyperexcitable CA1 dendrites after febrile seizures. (18946517)
2008
31
Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures. (17340635)
2007
32
Mutations in GABRA1, GABRA5, GABRG2 and GABRD receptor genes are not a major factor in the pathogenesis of familial focal epilepsy preceded by febrile seizures. (16256272)
2006
33
The Danish National Hospital Register is a valuable study base for epidemiologic research in febrile seizures. (16360562)
2006
34
Hydrogen sulfide and carbon monoxide are in synergy with each other in the pathogenesis of recurrent febrile seizures. (16633905)
2006
35
Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis. (16819552)
2006
36
Role of viral infections in the etiology of febrile seizures. (16939854)
2006
37
Information from your family doctor. Febrile seizures: what you should know. (16734053)
2006
38
Familial occurrence of febrile seizures and epilepsy in severe myoclonic epilepsy of infancy (SMEI) patients with SCN1A mutations. (17054684)
2006
39
Soluble Telencephalin in the serum of children after febrile seizures. (15726263)
2005
40
Adult-onset epilepsy and history of childhood febrile seizures: a retrospective study. (15626834)
2004
41
Clinical correlations of mutations in the SCN1A gene: from febrile seizures to severe myoclonic epilepsy in infancy. (15087100)
2004
42
. . . about febrile seizures. (12035662)
2002
43
Generalized epilepsy with febrile seizures plus: mutation of the sodium channel subunit SCN1B. (12011299)
2002
44
Interleukin-1beta, tumor necrosis factor-alpha, and nitrite levels in febrile seizures. (12546429)
2002
45
Children with onset of febrile seizures after the age of 5 years. (12269738)
2002
46
Clinical and genetic analysis of a new multigenerational pedigree with GEFS+ (Generalized Epilepsy with Febrile Seizures Plus). (12060016)
2002
47
Febrile seizures. (12356222)
2002
48
Febrile seizures. (11463960)
2001
49
Intranasal midazolam for treating febrile seizures in children. Buccal midazolam for childhood seizures at home preferred to rectal diazepam. (11203721)
2001
50
Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 in cerebrospinal fluid from children with prolonged febrile seizures. Comparison with acute encephalitis/encephalopathy. (9484363)
1998

Genetic Variations for Febrile Seizures

Expression for genes affiliated with Febrile Seizures

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Febrile Seizures

Search GEO for disease gene expression data for Febrile Seizures.

Pathways for genes affiliated with Febrile Seizures

Sources:
30KEGG, 12EMD Millipore, 52QIAGEN, 54Reactome
See all sources

Compounds for genes affiliated with Febrile Seizures

Sources:
11DrugBank, 45Novoseek, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 50PharmGKB
See all sources

Compounds related to Febrile Seizures according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1Cinolazepam1110.8GABRG2, GABRD
2Halazepam1110.8GABRG2, GABRD
3lamotrigine45 1111.8SCN1A, SCN2A
4Fludiazepam1110.8GABRG2, GABRD
5(+)-bicuculline6010.8GABRD, GABRG2
6(-)-bicuculline methochloride6010.7GABRD, GABRG2
7nitrazepam45 1111.7GABRG2, GABRD, SCN1A
8(-)-bicuculline methiodide6010.7GABRD, GABRG2
9aft-ii2910.7SCN2A, SCN8A, SCN1A
10bc-iii2910.7SCN2A, SCN8A, SCN1A
11sr 95531 hydrobromide6010.7GABRD, GABRG2
12atx-ii2910.7SCN2A, SCN8A, SCN1A
13Prazepam1110.7GABRD, GABRG2
14estazolam45 1111.7GABRG2, GABRD
15saxitoxin2910.7SCN1A, SCN9A, SCN8A, SCN2A
16batrachotoxin2910.7SCN2A, SCN8A, SCN9A, SCN1A
17Adinazolam1110.7GABRG2, GABRD
18quazepam45 1111.7GABRG2, GABRD
19zonisamide45 1111.7SCN2A, SCN1B, SCN9A, SCN1A
20phrixotoxin 36010.7SCN1A, SCN2A, SCN1B, SCN8A, SCN9A
21Clotiazepam1110.7GABRD, GABRG2
22qx 314 chloride6010.7SCN2A, SCN1B, SCN8A, SCN9A, SCN1A
23tetrodotoxin citrate6010.7SCN2A, SCN1B, SCN8A, SCN9A, SCN1A
24veratridine45 60 2912.7SCN2A, SCN1B, SCN8A, SCN9A, SCN1A
25Clorazepate1110.7GABRG2, GABRD
26tetrodotoxin45 60 2912.7SCN2A, SCN1B, SCN8A, SCN9A, SCN1A
27bromazepam45 1111.7GABRG2, GABRD
28Temazepam1110.6GABRD, GABRG2
29potassium45 11 2412.6KCNQ2, SCN1B, SCN8A, SCN1A, GABRG2
30lorazepam45 50 1112.6GABRD, GABRG2
31flurazepam45 1111.6GABRD, GABRG2
32oxazepam50 1111.6GABRD, GABRG2
33clobazam45 50 1112.6GABRD, GABRG2
34sodium45 2411.5KCNQ2, SCN2A, SCN7A, SCN1B, SCN8A, SCN9A
35chlordiazepoxide45 1111.5GABRD, GABRG2
36tbps45 2911.5GABRD, GABRG2
37clonazepam45 1111.4GABRD, GABRG2
38alprazolam45 1111.4GABRG2, GABRD
39muscimol45 60 2912.3GABRG2, GABRD
40triazolam45 1111.1GABRG2, GABRD

GO Terms for genes affiliated with Febrile Seizures

Sources:
16Gene Ontology
See all sources

Cellular components related to Febrile Seizures according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intercalated discGO:01470410.4SCN1A, SCN1B, SCN2A
2voltage-gated sodium channel complexGO:00151810.3SCN1A, SCN9A, SCN8A, SCN1B, SCN7A, SCN2A
3node of RanvierGO:03326810.3KCNQ2, SCN2A, SCN1B, SCN8A, SCN1A
4axon initial segmentGO:04319410.2SCN1A, SCN8A, KCNQ2
5T-tubuleGO:03031510.1SCN2A, SCN1B, SCN1A

Biological processes related to Febrile Seizures according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal action potential propagationGO:01922710.5SCN1A, SCN1B
2regulation of action potential in neuronGO:01922810.4SCN9A, SCN1A
3myelinationGO:04255210.4SCN8A, SCN2A
4sodium ion transportGO:00681410.4SCN1A, SCN9A, SCN8A, SCN7A, SCN2A
5synaptic transmissionGO:00726810.2GABRG2, GABRD, SCN1B, KCNQ2
6adult walking behaviorGO:00762810.1SCN1A, SCN8A

Molecular functions related to Febrile Seizures according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular ligand-gated ion channel activityGO:00523010.4GABRG2, GABRD
2GABA-A receptor activityGO:00489010.1GABRG2, GABRD
3voltage-gated sodium channel activityGO:00524810.1SCN1A, SCN2A, SCN7A, SCN1B, SCN8A, SCN9A

Products for genes affiliated with Febrile Seizures

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Febrile Seizures

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet