Febrile Seizures malady

NINDS: Febrile seizures are convulsions brought on by a fever in infants or small children. During a febrile seizure, a child often loses consciousness and shakes.³¹

MalaCards: Febrile Seizures, also known as febrile convulsions, is related to generalized epilepsy with febrile seizures plus and convulsions. An important gene associated with Febrile Seizures is GABRD (gamma-aminobutyric acid (GABA) A receptor, delta), and among its related pathways are Bacterial infections in CF airways and RAR-Gamma-RXR-Alpha Degradation. The drugs phenobarbital and phenobarbital sodium and the compounds ivig and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and temporal lobe, and related mouse phenotypes are respiratory system and hematopoietic system.

febrile seizures 31 febrile convulsions 43

seizures febrile 32

Diseases related to febrile seizures by text searches and GeneDecks gene sharing:

(show top 50)    (show all 649)

id	Related Disease	Score	Top Affiliating Genes
1	generalized epilepsy with febrile seizures plus	37.0	KCNQ2, SCN1B, SCN1A, LGI1, CHRNB2, GABRG2
2	convulsions	33.8	BDNF, KCNQ2, SCN1B, SCN2A, SCN9A, SCN1A
3	dravet syndrome	33.3	SCN1B, SCN2A, SCN9A, SCN1A, GABRG2
4	temporal lobe epilepsy	32.1	BDNF, SCN1B, LGI1, CALB1, GLUL, GJA1
5	absence epilepsy	32.0	SGCZ, SCN1B, MTMR9, GABBR1, GABRG2, GABRA5
6	severe myoclonic epilepsy of infancy (smei)	31.6	SCN1B, SCN2A, SCN1A, GABRG2
7	seizure disorder	30.0	KCNQ2, SCN2A, SCN1A
8	focal epilepsy	29.9	SCN1A, LGI1, GABRG2
9	epilepsy syndrome	29.9	KCNQ2, SCN1B, SCN1A, CASR
10	convulsions, familial febrile, 4	29.8	FEB4, GPR98
11	febrile convulsions	29.3	KCNQ2, SCN9A, SCN1A, IL1B, IL1R1, GPR98
12	bipolar disorder	27.3	CNR1, BDNF, KCNQ2, SCN8A, CHRNB2, IMPA1
13	seizures	26.2	SGCZ, CNR1, SEZ6, VIM, BDNF, KCNQ2
14	encephalitis	26.0	CNR1, BDNF, SCN1A, LGI1, IL10, IL1B
15	influenza	25.6	IL10, IL1A, IL1B, IL1RN, IL4, IL6
16	schizophrenia	22.8	CNR1, VIM, BDNF, KCNQ2, CHRNB2, MMP9
17	obesity	22.7	CNR1, BDNF, SCN2A, MTMR9, MMP9, IL10
18	neuronitis	22.2	CNR1, SEZ6, VIM, BDNF, KCNQ2, SCN7A
19	benign familial neonatal-infantile seizures	13.9	KCNQ2, SCN1B, SCN1A, GABRG2
20	autosomal dominant nocturnal frontal lobe epilepsy	13.8	KCNQ2, SCN1B, SCN1A, CHRNB2, GABRG2
21	merrf syndrome	13.8	SCN1B, SCN1A, GABRG2
22	juvenile myoclonic epilepsy	13.8	SCN1A, GABBR1, GABRG2
23	idiopathic generalized epilepsy	13.8	KCNQ2, SCN1A, LGI1, GABBR1, GABRG2
24	erythromelalgia	13.8	SCN7A, SCN9A, SCN8A
25	epilepsies, partial	13.7	SCN1A, LGI1, GABRG2
26	epilepsy with generalized tonic-clonic seizures	13.7	SCN2A, SCN1A
27	erythermalgia	13.7	SCN7A, SCN9A
28	familial cold autoinflammatory syndrome	13.5	IL1B, IL1R1, CASP1
29	gastric cancer risk after h. pylori infection	13.4	IL1B, IL1RN
30	stachybotrys chartarum	13.4	IL1A, IL1B, CCL4
31	post-traumatic stress disorder	13.4	CNR1, BDNF, NPY
32	lung giant cell carcinoma	13.4	VIM, GJA1, TIMP1
33	somatoform disorder	13.4	IL1A, IL1B, IL1RN
34	neisseria meningitidis infection	13.4	IL1R1, IL1RN, TLR4, C3
35	subependymal giant cell astrocytoma	13.3	VIM, CALB1, NPY
36	meningococcemia	13.3	IL1A, IL1B, IL1RN
37	labyrinthitis	13.3	IL10, CALB1, NPY
38	malignant histiocytosis	13.3	IL1A, IL1B, IL1R1
39	usher syndrome, type iic	13.3	FEB4, GPR98
40	cinca syndrome	13.3	IL1B, IL1R1, IL1RAPL2, CASP1
41	mood disorder	13.3	CNR1, BDNF, IMPA1, IMPA2, NPY, GABBR1
42	anxiety disorder	13.2	CNR1, BDNF, NPY, GABBR1
43	multiple sclerosis	13.2	IL1A, IL1B, IL1RN, IL26, GABBR1
44	alcoholism	13.2	CNR1, IL1RN, NPY, C3, GABBR1
45	ventricular fibrillation	13.2	SCN1B, MMP9, ENO2, TLR4, SLC9A1
46	adult-onset still's disease	13.2	IL1R1, IL1RAPL2, IL6
47	huntington's disease	13.2	CNR1, BDNF, CBS, CALB1, NPY
48	diabetic neuropathy	13.1	CNR1, SCN9A, IL1B, IL1RN, TLR4
49	central nervous system leukemia	13.1	IL1B, TNF
50	autonomic dysfunction	13.1	BDNF, SCN9A, IL6, NPY

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 phenobarbital, phenobarbital sodium

MalaCards organs/tissues related to febrile seizures:

²²

MGI Mouse Phenotypes related to febrile seizures:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.1	SCN8A, KCNQ2, BDNF, SLC4A3, CHRNB2, CBS
2	hematopoietic system phenotype	MP:0005397	10.0	CHRNB2, GJA1, CASR
3	renal/urinary system phenotype	MP:0005367	9.9	SLC9A3, CASR, CBS, CHRNB2, C3
4	digestive/alimentary phenotype	MP:0005381	9.2	BDNF, CHRNB2, MMP9, CASP1, CASR, NPY
5	hearing/vestibular/ear phenotype	MP:0005377	9.1	GABRD, TLR4, GJA1, CALB1, GPR98, CHRNB2
6	skeleton phenotype	MP:0005390	9.0	C3, CNR1, SCN8A, IL1R1, IL6, GJA1
7	integument phenotype	MP:0010771	8.7	SLC4A3, HCN2, CNR1, BDNF, SCN9A, LGI1
8	immune system phenotype	MP:0005387	8.6	GJA1, CASP1, CBS, IL6, TNF, VIM
9	growth/size phenotype	MP:0005378	8.4	HCN2, LGI1, GABBR1, SLC17A7, SLC9A1, KCNQ2
10	nervous system phenotype	MP:0003631	8.3	GPR98, ICAM5, CALB1, CASP1, GLUL, HCN2
11	homeostasis/metabolism phenotype	MP:0005376	7.7	GABRG2, CASR, C3, SLC9A1, SLC9A3, SLC4A3
12	muscle phenotype	MP:0005369	7.4	GJA1, C3, VIM, SCN8A, CHRNB2, MMP9
13	reproductive system phenotype	MP:0005389	7.0	C3, SCN1A, IL6, KCNQ2, SCN8A, MMP9
14	vision/eye phenotype	MP:0005391	7.0	CHRNB2, GJA1, TNF, SLC17A7, SLC4A3, CASR
15	cardiovascular system phenotype	MP:0005385	6.4	IL6, IL1RN, IL1R1, IL1A, IL10, MMP9
16	cellular phenotype	MP:0005384	6.0	SCN8A, TNF, CNR1, CBS, CASP1, CASR
17	behavior/neurological phenotype	MP:0005386	5.5	CNR1, SCN8A, SCN9A, SCN1B, SCN7A, KCNQ2
18	mortality/aging	MP:0010768	5.1	MMP9, IMPA1, IL10, IL1B, IL1R1, GABRG2

Articles related to febrile seizures:

(show top 50)    (show all 102)

id	Title	Authors	Year	Affiliating Genes
1	IL-8 in cerebrospinal fluid from children with acute encephalopathy is higher than in that from children with febrile seizure. (20500697)	Asano T.... Fukunaga Y.	2010	CCL4
2	Generalized epilepsy with febrile seizures plus: nove l SCN1A mutation. (20117752)	Dimova P.S.... Kremenski I.	2010	SCN1A
3	Generalized epilepsy with febrile seizures plus (GEFS +) spectrum: clinical manifestations and SCN1A mutations in Indonesian patients . (20452746)	Herini E.S.... Nishio H.	2010	SCN1A
4	Interleukin (IL)-1beta, IL-1 receptor antagonist, IL- 6, IL-8, IL-10, and tumor necrosis factor alpha gene polymorphisms in patients with febrile seizures. (20486195)	Chou I.C.... Tsai F.J.	2010	TNF, IL6, IL1B
5	Functional variant in complement C3 gene promoter and genetic susceptibility to temporal lobe epilepsy and febrile seizures. (20862287)	Jamali S.... Szepetowski P.	2010	C3
6	Novel mutation of SCN1A in familial generalized epilepsy with febrile seizures plus. (20600615)	Li N.... Tang B.S.	2010	SCN1A
7	A splice site variant in the sodium channel gene SCN1A confers risk of febrile seizures. (19289736)	Schlachter K.... Zimprich F.	2009	SCN1A
8	A novel inherited mutation in the voltage sensor region of SCN1A is associated with Panayiotopoulos syndrome in siblings and generalized epilepsy with febrile seizures plus. (19339291)	Livingston J.H.... Zuberi S.M.	2009	SCN1A
9	Clinical analysis and screening for SCN1A gene mutat ion in two pedigrees of generalized epilepsies with febrile seizures plus (19951487)	Wang X.H.... Sun D.K.	2009	SCN1A
10	Lack of replication of association between scn1a SNP and febrile seizures. (19949041)	Petrovski S.... Berkovic S.F.	2009	SCN1A
11	Progress in searching for the febrile seizure susceptibility genes. (19201561)	Nakayama J.	2009	GABRG2, SCN1A, SCN1B
12	Interleukin-10 is associated with resistance to febrile seizures: Genetic association and experimental animal studies. (19055487)	Ishizaki Y.... Hara T.	2008	TNF, IL6, IL8
13	Linkage location and mutation analysis of generalized epilepsy with febrile seizures plus (19171087)	Lin H.... Wu L.W.	2008	GABRG2, SCN1A, SCN1B
14	A novel locus for generalized epilepsy with febrile seizures plus in French families. (18625863)	Baulac S.... Nabbout R.	2008	GABRG2, SCN1A, SCN1B
15	Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients. (17388992)	Blair M.A.... Hedera P.	2007	IMPA2
16	Neuropeptide Y gene polymorphism and plasma neuropeptide Y level in febrile seizure patients in Taiwan. (18055304)	Lin L.C.... Yang R.C.	2007	NPY
17	Association analysis of gamma2 subunit of gamma-aminobutyric acid (GABA) type A receptor and voltage-gated sodium channel type II alpha-polypeptide gene mutation in southern Chinese children with febrile seizures. (17641256)	Xiumin Wang .... Lizhong Du .	2007	GABRG2, SCN2A
18	Electroclinical features of a family with simple febrile seizures and temporal lobe epilepsy associated with SCN1A loss-of-function mutation. (17565594)	Colosimo E.... Quattrone A.	2007	SCN1A
19	Febrile seizures are associated with mutation of seizure-related (SEZ) 6, a brain-specific gene. (17086543)	Yu Z.L.... Bao G.S.	2007	SEZ6
20	Mutations in GABRA1, GABRA5, GABRG2 and GABRD receptor genes are not a major factor in the pathogenesis of familial focal epilepsy preceded by febrile seizures. (16256272)	Ma S.... Hedera P.	2006	GABRG2, GABRA5, GABRD
21	Phenotypes and genotypes in epilepsy with febrile seizures plus. (16884893)	Ito M.... Kaneko S.	2006	GABRG2, SCN1A, SCN1B
22	Familial occurrence of febrile seizures and epilepsy in severe myoclonic epilepsy of infancy (SMEI) patients with SCN1A mutations. (17054684)	Mancardi M.M.... Zara F.	2006	SCN1A
23	Identification of a novel locus for febrile seizures and epilepsy on chromosome 21q22. (17054683)	Hedera P.... Haines J.L.	2006	FEB7
24	Increased IL-1beta production from dsRNA-stimulated leukocytes in febrile seizures. (16876005)	Matsuo M.... Hamasaki Y.	2006	IL1R1
25	Genome-wide linkage of febrile seizures and epilepsy to the FEB4 locus at 5q14.3-q23.1 and no MASS1 mutation. (16273391)	Deprez L.... De Jonghe P.	2006	GABRG2, SCN1B
26	A family of generalized epilepsy with febrile seizures plus type 2-a new missense mutation of SCN1A found in the pedigree of several patients with complex febrile seizures. (15715999)	Nagao Y.... Yamakawa K.	2005	SCN1A
27	Endogenous neuropeptide Y prevents recurrence of expe rimental febrile seizures by increasing seizure threshold. (15800380)	DubAc C.... Baram T.Z.	2005	NPY
28	The GABBR1 locus and the G1465A variant is not associated with temporal lobe epilepsy preceded by febrile seizures. (15799783)	Ma S.... Hedera P.	2005	GABBR1
29	Identification of an Nav1.1 sodium channel (SCN1A) loss-of-function mutation associated with familial simple febrile seizures. (16326807)	Mantegazza M.... Quattrone A.	2005	SCN1A
30	Generalized epilepsy with febrile seizures plus: clinical and genetic analysis of three Serbian families (16053169)	Ristic A.J.... Sokic D.	2005	GABRG2, SCN1A, SCN1B
31	Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18. (15557493)	Nakayama J.... Arinami T.	2004	IMPA2, IMPA1, FEB6
32	Increased neuronal firing in computer simulations of sodium channel mutations that cause generalized epilepsy with febrile seizures plus. (14702334)	Spampanato J.... Goldin A.L.	2004	SCN1A, SCN1B
33	The GABAA receptor gamma2 subunit R43Q mutation linked to childhood absence epilepsy and febrile seizures causes retention of alpha1beta2gamma2S receptors in the endoplasmic reticulum. (15470132)	Kang J.Q.... Macdonald R.L.	2004	GABRG2
34	Association of the nicotinic receptor beta 2 subunit and febrile seizures. (15033200)	Peng C.T.... Tsai F.J.	2004	CHRNB2
35	Novel locus on chromosome 12q22-q23.3 responsible for familial temporal lobe epilepsy associated with febrile seizures. (15342703)	Claes L.... De Jonghe P.	2004	ETL2
36	Serum neuron-specific enolase in children with febrile seizures: time profile and prognostic implications. (12767459)	Borusiak P.... Herbold S.	2003	ENO2
37	Two novel SCN1A missense mutations in generalized epilepsy with febrile seizures plus. (12919402)	Annesi G.... Quattrone A.	2003	SCN1A
38	Mutation analysis of the leucine-rich, glioma inactivated 1 gene (LGI1) in Japanese febrile seizure patients. (14598228)	Nakayama J.... Arinami T.	2003	LGI1
39	Functional characterization of the D188V mutation in neuronal voltage-gated sodium channel causing generalized epilepsy with febrile seizures plus (GEFS). (12576172)	Cossette P.... Rouleau G.A.	2003	SCN1A
40	Association analysis of gamma 2 subunit of gamma- aminobutyric acid type A receptor polymorphisms with febrile seizures. (12672902)	Chou I.C.... Tsai C.H.	2003	GABRG2
41	Interleukin-4 intron 3 polymorphism is not related to susceptibility to febrile seizures. (12435565)	Tsai F.J.... Tsai C.H.	2002	IL4
42	Lack of SCN1A mutations in familial febrile seizures. (12027919)	Malacarne M.... Zara F.	2002	SCN1A
43	Possible contribution of interferon-alpha to febrile seizures in influenza. (12435568)	Masuyama T.... Hamasaki Y.	2002	IFNA1
44	Increased frequency of interleukin-1beta (-511) allele 2 in febrile seizures. (11955925)	Virta M.... Helminen M.	2002	IL1B
45	Generalized epilepsy with febrile seizures plus: mutation of the sodium channel subunit SCN1B. (12011299)	Wallace R.H.... Mulley J.C.	2002	SCN1B
46	Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. (11326275)	Wallace R.H.... Berkovic S.F.	2001	GABRG2
47	Cerebrospinal fluid and serum neuron-specific enolase levels after febrile seizures. (11440345)	Tanabe T.... Tamai H.	2001	ENO2
48	Cerebrospinal fluid purine metabolite and neuron-specific enolase concentrations after febrile seizures. (11102727)	RodrA-guez-NA_A+ez A.... Castro-Gago M.	2000	ENO2
49	A locus for febrile seizures (FEB3) maps to chromosome 2q23-24. (10514109)	Peiffer A.... Leppert M.	1999	SCN1A
50	Febrile seizures and generalized epilepsy associated with a mutation in the Na(+)-channel beta-1 subunit gene SCN1B. (9697698)	Wallace R.H.... Mulley J.C.	1998	SCN1B

Genes related to febrile seizures according to GeneCards:

(show top 50)    (show all 69)

id	Symbol	Description	Score	GeneCards Section Context
1	GABRD	gamma-aminobutyric acid (GABA) A receptor, delta	11.1	Summaries, Publications
2	GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	11.1	Publications, Summaries
3	GEFSP6	Generalized epilepsy with febrile seizures plus, type 6	11.1	Aliases & Descriptions
4	SCN1B	sodium channel, voltage-gated, type I, beta subunit	11.1	Publications, Summaries
5	GEFSP4	Epilepsy, generalized, with febrile seizures plus, type 4	11.1	Aliases & Descriptions
6	GPR98	G protein-coupled receptor 98	11.1	Summaries, Publications
7	GEFSP8	Generalized epilepsy with febrile seizures plus, type 8	11.1	Aliases & Descriptions
8	SCN1A	sodium channel, voltage-gated, type I, alpha subunit	11.0	Publications
9	MTMR9	myotubularin related protein 9	11.0	Publications
10	SCN7A	sodium channel, voltage-gated, type VII, alpha subunit	11.0	Publications
11	SCN2A	sodium channel, voltage-gated, type II, alpha subunit	11.0	Publications
12	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit	11.0
13	SCN8A	sodium channel, voltage gated, type VIII, alpha subunit	11.0	Publications
14	KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	11.0	Publications
15	SGCZ	sarcoglycan, zeta	11.0	Publications
16	ETL2	epilepsy, familial temporal lobe	11.0	Publications
17	TAAR3	trace amine associated receptor 3 (gene/pseudogene)	11.0	Publications
18	ICAM5	intercellular adhesion molecule 5, telencephalin	11.0	Publications
19	TAAR2	trace amine associated receptor 2	11.0	Publications
20	GABRE	gamma-aminobutyric acid (GABA) A receptor, epsilon	11.0	Publications
21	IL26	interleukin 26	11.0	Publications
22	SLC4A3	solute carrier family 4, anion exchanger, member 3	11.0	Publications
23	SEZ6	seizure related 6 homolog (mouse)	11.0	Publications
24	IMPA2	inositol(myo)-1(or 4)-monophosphatase 2	11.0	Publications
25	SLC17A7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	11.0	Publications
26	STX7	syntaxin 7	11.0	Publications
27	CSNK1G2	casein kinase 1, gamma 2	11.0	Publications
28	CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	11.0	Publications
29	IMPA1	inositol(myo)-1(or 4)-monophosphatase 1	11.0	Publications
30	LGI1	leucine-rich, glioma inactivated 1	11.0	Publications
31	HCN2	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	11.0	Publications
32	SLC9A3	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	11.0	Publications
33	SLC9A1	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	11.0	Publications
34	AKAP7	A kinase (PRKA) anchor protein 7	11.0	Publications
35	GLUL	glutamate-ammonia ligase	11.0	Publications
36	GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	11.0	Publications
37	GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	11.0	Publications
38	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
39	CPA6	carboxypeptidase A6	11.0	Publications
40	CALB1	calbindin 1, 28kDa	11.0	Publications
41	CBS	cystathionine-beta-synthase	11.0	Publications
42	CNR1	cannabinoid receptor 1 (brain)	11.0	Publications
43	C3	complement component 3	11.0	Publications
44	NPY	neuropeptide Y	11.0	Publications
45	GJA1	gap junction protein, alpha 1, 43kDa	11.0	Publications
46	CASP1	caspase 1, apoptosis-related cysteine peptidase	11.0	Publications
47	CCL4	chemokine (C-C motif) ligand 4	11.0	Publications
48	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
49	IL1R1	interleukin 1 receptor, type I	11.0	Publications
50	CASR	calcium-sensing receptor	11.0

Pathways related to febrile seizures according to GeneDecks:

(show top 50)    (show all 74)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.7	IL1R1
2	RAR-Gamma-RXR-Alpha Degradation36	10.6	IL26, CCL4
3	Sodium channels and transporters- inward current10	10.4	SCN9A, SCN2A, SCN8A, SCN1A, HCN2
4	GABA signaling in brain10	10.3	GABBR1, GABRA5, GABRD, GABRE, GABRG2
5	Immune response_Bacterial infections in normal airways41	10.2	IL1B, IL1R1
6	NFAT Signaling and Lymphocyte Interactions36	10.1	IL1A, CCL4, IL26, IL4
7	Regulation of eIF4 and p70S6K36	9.6	IL6, CCL4, IL26, IL1A, IL4
8	Th17 Differentiation37	9.4	IL1B, IL1R1, IL26, IL6, TLR4
9	14-3-3 Induced Apoptosis36	9.3	IL1B, CASP1, TNF, IL1R1, TLR4, IL1A
10	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.2	TNF, CALB1, IL1B, IL6, IL1A
11	Endothelin-1 Signaling Pathway36	9.1	IL10, IL1A, IL26, IL1B, CASP1, IL4
12	Immune response MIF in innate immunity response10	9.1	IL6, IL8, IL1B, TNF, TLR4
13	HMGB1 Pathway36	9.1	IL1A, IL1B, IL1R1, TNF, TLR4
14	Immune response_MIF in innate immunity response41	9.1	TNF, IL8, IL6, IL1B, TLR4
15	Leishmaniasis20	8.9	IL10, IL1A, TLR4, TNF, IL4, IL1B
16	Malaria20	8.9	IL6, IL8, IL1B, TNF, TLR4, IL10
17	Immune response IL-1 signaling pathway10	8.9	IL1B, IL6, TNF, IL8, IL1R1, IL1A
18	Akt Signaling36	8.9	GABRE, GABRG2, GABRA5, TNF, CCL4, IL6
19	Immune response_IL-1 signaling pathway41	8.9	TNF, HMOX1, IL8, IL6, IL1R1, IL1B
20	Hematopoietic cell lineage20	8.8	IL1B, IL1R1, IL4, TNF, IL6, IL1A
21	IL-10 Pathway36	8.8	IL1A, IL1B, IL6, HMOX1, TNF, IL10
22	SOCS Pathway36	8.8	CCL4, IL10, IL1A, IL1B, IL26, IL6
23	Toll-like receptor signaling pathway20	8.8	IL8, CCL4, IFNA1, TNF, TLR4, IL6
24	Chagas disease (American trypanosomiasis)20	8.7	TNF, IL6, IL8, C3, TLR4, IL10
25	PGC1Alpha Pathway36	8.7	IL26, IL1B, CCL4, IL8, IL6, IL1R1
26	Amoebiasis20	8.7	IL6, IL1R1, IL10, IL8, TNF, TLR4
27	Rheumatoid arthritis20	8.7	TLR4, IL1A, IL1B, IL6, IL8, TNF
28	Tec Kinases Signaling36	8.7	IL8, IL6, CCL4, TIMP1, BDNF, TLR4
29	NF-KappaB (p50-p65) Pathway36	8.7	IL1A, IL6, TNF, TLR4, TIMP1, IL1R1
30	Glucocorticoid Receptor Signaling36	8.6	IL4, IL26, IL10, IL1R1, IL1A, IL1B
31	NF-KappaB Family Pathway36	8.6	TNF, BDNF, TIMP1, TLR4, IL6, IL1R1
32	Influenza A20	8.6	IL1A, IL1B, IL8, IFNA1, TNF, TLR4
33	Tuberculosis20	8.5	IL10, IL6, IL1A, IL1B, IFNA1, TNF
34	Pertussis20	8.5	C3, IL1A, TNF, IL6, IL8, CASP1
35	Cytokine Network36	8.4	IL4, IL10, IL1A, IL1B, IL6, IL8
36	all-trans-Retinoic Acid Signaling in Brain36	8.4	IL10, TNF, CCL4, IL8, IL6, IL4
37	ERK Signaling36	8.4	IL26, IL1A, TIMP1, IL6, IL4, IL10
38	TGF-Beta Pathway36	8.3	BDNF, IL10, IL1B, IL1R1, IL4, IL26
39	PEDF Induced Signaling36	8.3	IL1A, IL10, TNF, CCL4, BDNF, IL1B
40	STAT3 Pathway36	8.2	CCL4, IL8, IL6, IL4, IL26, IL1R1
41	MIF Mediated Glucocorticoid Regulation36	8.2	IL1B, TLR4, TNF, CCL4, IL8, IL6
42	MIF Regulation of Innate Immune Cells36	8.2	CCL4, IL6, IL8, IL1A, IL10, IL4
43	IL-6 Pathway36	8.2	IL10, IL1A, IL1B, IL26, IL4, TIMP1
44	JAK-STAT Pathway36	8.0	BDNF, IL10, IL1A, IL1B, IL1R1, IL26
45	Cytokine-cytokine receptor interaction20	8.0	IL1R1, IL1B, IL10, IL26, IL1A, IL6
46	PAK Pathway36	7.9	IL26, IL4, IL6, IL8, CCL4, CASP1
47	MAPK Family Pathway36	7.8	IL10, BDNF, IL1A, IL1R1, IL26, IL4
48	Antioxidant Action of Vitamin-C36	7.8	IL1R1, IL6, TNF, BDNF, IL10, IL1A
49	p38 Signaling36	7.8	IL1R1, IL1B, IL1A, IL10, BDNF, IL26
50	Rho Family GTPases36	7.6	IL1A, IL1B, IL8, CCL4, TNF, TIMP1

Compounds related to febrile seizures according to GeneDecks:

(show top 50)    (show all 239)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.4	IL1RAPL2, CCL4
2	endotoxin32	9.9	CASP1, IL1R1, IL1RAPL2, CCL4
3	muscimol32 42	10.8	BDNF, GABRA5, GABRG2, GABRE, GABRD, GABBR1
4	n acetylcysteine32	9.6	TLR4, BDNF, MMP9, TIMP1, IL1R1
5	cysteine32	9.0	CASR, HMOX1, HCN2, SLC9A3, C3, GABBR1
6	pge232	9.0	GJA1, HMOX1, TLR4, CASR, CCL4, IL1RN
7	polyinosinic-polycytidylic acid32	8.9	TLR4, IFNA1, IL8, IL6, IL10, IL4
8	potassium32 9 18 9	11.9	GABRG2, GABBR1, SLC9A1, SLC9A3, HCN2, GJA1
9	gaba32 42	9.9	GABRA5, GABRG2, GABBR1, GLUL, CNR1, VIM
10	anakinra32 9 9	10.9	IL1B, IL1R1, TNF, IL1RAPL2, IL6, CASP1
11	sodium32 18	9.9	LGI1, SCN1A, SCN8A, SCN9A, SCN2A, SCN1B
12	h2o232	8.8	TLR4, GJA1, GLUL, CASP1, CBS, IL1RAPL2
13	taurine chloramine32	8.7	IL1B, TNF, TIMP1, IL6, IL8, HMOX1
14	mip 1alpha32	8.6	IL8, CCL4, IL6, IL4, IL1B, IL10
15	lipoteichoic acid32	8.4	IL1B, IL1R1, IL1RN, IL10, IL8, TNF
16	sb 20358032 42	9.4	CCL4, CASP1, GJA1, HMOX1, TNF, TIMP1
17	il-1232	8.4	IFNA1, TNF, IL1B, IL1R1, IL8, IL6
18	nmda32 42	9.3	CALB1, CBS, ENO2, IL1RN, CASP1, IL1R1
19	vegf32	8.3	MMP9, IL1RN, HMOX1, GJA1, CCL4, ENO2
20	acetylcholine32 9 18 9	11.3	CNR1, VIM, GJA1, HMOX1, TLR4, NPY
21	poly(i-c)32	8.3	TLR4, TNF, CASP1, IFNA1, IL8, IL6
22	imiquimod32 42 9 9	11.2	TLR4, IL1RAPL2, TNF, IL6, IL8, IFNA1
23	peptidoglycan32	8.2	IL1RN, IL1R1, IL1B, IL8, IL10, CCL4
24	polymyxin b32	8.2	TLR4, TNF, IL8, IL10, IL1A, IL1B
25	rantes32	8.2	IL1R1, MMP9, IFNA1, IL1A, IL1RAPL2, IL4
26	etanercept32 9 9	10.2	TNF, IL8, IL1RN, TIMP1, IL1RAPL2, IL1B
27	creatinine32	8.2	BDNF, NPY, C3, SLC9A3, GLUL, CASR
28	glutamate32	8.1	TIMP1, CASR, GLUL, SLC17A7, CASP1, SLC9A1
29	histamine32 18	9.1	CASP1, CCL4, IL4, IL1RN, IL1RAPL2, KCNQ2
30	pdtc32	8.0	TNF, IL6, TLR4, MMP9, IL1A, HMOX1
31	infliximab32 9 9	9.9	IL6, TIMP1, TLR4, IL4, TNF, IL10
32	ccl332	7.8	TLR4, MMP9, IL10, TNF, IFNA1, CCL4
33	hydrocortisone32 9 9	9.8	IL1R1, IL8, GLUL, TNF, VIM, SLC9A3
34	pentoxifylline32 9 9	9.8	TNF, CASP1, IL8, IL6, IL4, IL1RAPL2
35	norepinephrine32 9 18 9	10.7	CALB1, GLUL, HMOX1, TIMP1, NPY, SLC9A1
36	prostaglandin32	7.6	IL1RN, TIMP1, TNF, GJA1, IL1A, CCL4
37	adenylate32	7.6	GLUL, GJA1, TIMP1, NPY, CNR1, GABBR1
38	il 1032	7.6	IL10, IL1RN, IL1A, TLR4, TNF, CCL4
39	neopterin32	7.5	IL1A, IL10, IL1B, IL1R1, C3, TNF
40	methotrexate32 34 42 9 9	11.5	IL1RN, IL10, IL1B, IL1R1, IL1RAPL2, IL6
41	simvastatin32 34 42 9 18 9	12.3	IL10, TLR4, TNF, IL1RN, IL4, IL6
42	indomethacin32 9 9	9.1	IL1RN, IL1RAPL2, IL1R1, IL1B, IL1A, BDNF
43	lactate32	6.7	CASP1, ENO2, IL8, IL6, IL1RN, IL1RAPL2
44	cyclosporin a32 42	7.3	IL1RAPL2, IL8, IL6, MMP9, IL10, IL1R1
45	actinomycin d32	6.2	IL1B, SLC9A3, TIMP1, TLR4, TNF, HMOX1
46	nitric oxide32 9 18 9	9.1	SLC9A3, NPY, CASR, IL1RN, CALB1, GLUL
47	retinoic acid32 42 18	8.0	TNF, CASP1, NPY, IFNA1, CALB1, GJA1
48	serine32	5.9	CASR, CASP1, CBS, GLUL, CNR1, GJA1
49	cycloheximide32	5.5	VIM, IL8, CCL4, IFNA1, CASP1, GLUL
50	dexamethasone32 42 34 9 9	9.4	CASP1, IL1R1, HMOX1, TNF, TLR4, TIMP1

Cellular components related to febrile seizures according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	voltage-gated sodium channel complex	GO:001518	10.4	SCN7A, SCN1B, SCN2A, SCN9A, SCN8A, SCN1A
2	node of Ranvier	GO:033268	10.3	KCNQ2, SCN2A, SCN8A
3	chloride channel complex	GO:034707	10.2	GABRG2, GABRE, GABRD, GABRA5
4	cell junction	GO:030054	9.9	LGI1, GABRA5, GABRG2, GABRE, GABRD, GABBR1
5	postsynaptic membrane	GO:045211	9.7	GABRG2, GABRE, GABRD, GABRA5, CHRNB2, GABBR1
6	integral to plasma membrane	GO:005887	8.7	SCN2A, CNR1, GABRE, GABRG2, IL1R1, ICAM5
7	extracellular region	GO:005576	7.5	GABBR1, IL1R1, C3, NPY, TIMP1, CASP1
8	plasma membrane	GO:005886	7.3	GJA1, C3, GABBR1, GABRG2, GABRA5, CASR
9	extracellular space	GO:005615	7.0	IL26, IL1RN, IL1A, MMP9, LGI1, IL4

Biological processes related to febrile seizures according to GeneDecks:

(show all 32)

id	Name	GO ID	Score	Top Affiliating Genes
1	sodium ion transport	GO:006814	10.5	SCN7A, SCN2A, SCN9A, SCN8A, SCN1A
2	gamma-aminobutyric acid signaling pathway	GO:007214	10.5	GABBR1, GABRA5, GABRG2, GABRE
3	ion transport	GO:006811	10.2	SLC9A1, CHRNB2, AKAP7, SLC17A7, SLC9A3, SLC4A3
4	memory	GO:007613	10.1	CNR1, CHRNB2, IL1RN, IL1B, CASP1
5	chronic inflammatory response to antigenic stimulus	GO:002439	10.0	IL1RN, IL1B, TNF
6	interleukin-1 beta production	GO:032611	10.0	CASP1, IL1B
7	positive regulation of fever generation	GO:031622	10.0	CNR1, IL1B, TNF
8	response to nicotine	GO:035094	10.0	MMP9, HMOX1, CHRNB2, GABBR1, CNR1
9	synaptic transmission	GO:007268	9.9	CHRNB2, KCNQ2, HCN2, SLC17A7, NPY, SCN1B
10	positive regulation of MHC class II biosynthetic process	GO:045348	9.9	TLR4, IL10, IL4
11	regulation of isotype switching	GO:045191	9.8	IL4, IL10
12	response to organic cyclic compound	GO:014070	9.7	SLC9A1, ENO2, IL4, IL1RN, CASP1, IL1A
13	positive regulation of cytokine secretion	GO:050715	9.7	TNF, IL26, IL1A, IL10
14	positive regulation of NF-kappaB import into nucleus	GO:042346	9.7	TLR4, TNF, IL1B
15	response to ethanol	GO:045471	9.6	GABBR1, TLR4, IL4, MMP9, CHRNB2, CNR1
16	positive regulation of chemokine biosynthetic process	GO:045080	9.6	IL1B, TNF, HMOX1, IL4
17	negative regulation of interleukin-6 production	GO:032715	9.6	IL10, TNF, TLR4
18	positive regulation of angiogenesis	GO:045766	9.6	MMP9, IL1A, C3, IL1B, HMOX1
19	positive regulation of JNK cascade	GO:046330	9.6	IL1A, IL1B, TLR4, TNF
20	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.5	TNF, IL1B, IL26, IL1A, TLR4
21	positive regulation of chemokine production	GO:032722	9.5	IL6, TNF, TLR4
22	positive regulation of interleukin-6 production	GO:032755	9.3	IL1A, IL6, IL1B, TNF, TLR4
23	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.2	IL1A, TNF, CASP1, GJA1, HMOX1, IL1B
24	response to glucocorticoid stimulus	GO:051384	9.2	TNF, SLC9A3, IL6, IL10, IL1B, IL1RN
25	response to hypoxia	GO:001666	9.2	CASP1, TLR4, TNF, CHRNB2, IL1B, IL1A
26	response to lipopolysaccharide	GO:032496	9.1	TLR4, MMP9, IL1A, CASP1, CNR1
27	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.0	TNF, IL1B, IL6, IL10, IL4
28	immune response	GO:006955	9.0	CCL4, C3, IL8, TLR4, IL1A, IL4
29	signal transduction	GO:007165	8.9	GABRD, CASP1, CHRNB2, IMPA1, IMPA2, IL1B
30	anti-apoptosis	GO:006916	8.8	TNF, HMOX1, IL1B, IL1A, IL10, BDNF
31	response to drug	GO:042493	8.6	CASP1, SLC9A1, HCN2, BDNF, MMP9, IL10
32	inflammatory response	GO:006954	8.6	C3, TNF, IL8, IL6, IL10, SCN9A

Molecular functions related to febrile seizures according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	voltage-gated sodium channel activity	GO:005248	10.3	SCN1A, SCN7A, SCN2A, SCN9A, SCN8A
2	GABA-A receptor activity	GO:004890	10.1	GABRE, GABRG2, GABRD, GABRA5
3	extracellular ligand-gated ion channel activity	GO:005230	9.9	GABRA5, GABRD, GABRE, GABRG2
4	interleukin-1 receptor binding	GO:005149	9.9	IL1B, IL1RN, IL1A
5	cytokine activity	GO:005125	8.3	TNF, CCL4, IL6, IL4, IL26, IL1A