MCID: FBR031
MIFTS: 47

Febrile Seizures malady

Genetic diseases (common) category

Summaries for Febrile Seizures

About this section


NINDS:42 Febrile seizures are convulsions brought on by a fever in infants or small children. During a febrile seizure, a child often loses consciousness and shakes.

MalaCards based summary: Febrile Seizures, also known as seizures febrile, is related to epilepsy, generalized, with febrile seizures plus, type 5 and dravet syndrome. An important gene associated with Febrile Seizures is GABRG2 (gamma-aminobutyric acid (GABA) A receptor, gamma 2), and among its related pathways are Nicotine addiction and GABA signaling in brain. The drugs phenobarbital and phenobarbital sodium and the compounds (+)-bicuculline and (-)-bicuculline methochloride have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and cortex, and related mouse phenotypes are mortality/aging and behavior/neurological.

Wikipedia:63 A febrile seizure, also known as a fever fit or febrile convulsion, is an epileptic seizure associated... more...

Aliases & Classifications for Febrile Seizures

About this section
Sources:
42NINDS, 43Novoseek, 22GTR, 60UMLS, 25ICD10
See all sources

Febrile Seizures, Aliases & Descriptions:

Name: Febrile Seizures 42
Seizures Febrile 43 22
 
Febrile Convulsions 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


External Ids:

ICD1025 R56.0

Related Diseases for Febrile Seizures

About this section

Diseases in the Febrile Seizures family:

Febrile Seizures, Familial, 9 Febrile Seizures, Familial, 10
Febrile Seizures, Familial, 4 Febrile Seizures, Familial, 5
Febrile Seizures, Familial, 11 Febrile Seizures, Familial, 1
Febrile Seizures, Familial, 6 Febrile Seizures, Familial, 2
Febrile Seizures, Familial, 7 Febrile Seizures, Familial, 3b

Diseases related to Febrile Seizures via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1epilepsy, generalized, with febrile seizures plus, type 530.9GABRG2, SCN1A
2dravet syndrome30.6GABRG2, GABRD, SCN1B, SCN1A
3focal epilepsy30.5SCN1B
4epilepsy syndrome30.5SCN1A, SCN1B, GABRG2
5generalized epilepsy with febrile seizures plus10.9
6neuronitis10.6
7febrile seizures, familial, 3b10.6
8epilepsy, generalized, with febrile seizures plus, type 110.6
9epilepsy, generalized, with febrile seizures plus, type 210.6
10temporal lobe epilepsy10.6
11epilepsy, generalized, with febrile seizures plus, type 310.6
12influenza10.6
13febrile seizures, familial, 110.5
14febrile seizures, familial, 1110.5
15febrile seizures, familial, 410.4
16febrile seizures, familial, 610.4
17meningitis10.4
18febrile seizures, familial, 910.4
19febrile seizures, familial, 510.4
20febrile seizures, familial, 210.4
21mental retardation, keratoconus, febrile seizures, and sinoatrial block10.4
22scn1a-related seizure disorders10.3SCN1A
23febrile seizures, familial, 1010.3
24generalized epilepsy with febrile seizures plus, type 910.3
25febrile seizures, familial, 710.3
26measles10.3
27attention deficit-hyperactivity disorder10.3
28deficiency anemia10.3
29childhood absence epilepsy10.3
30rubella10.3
31iron deficiency anemia10.3
32mumps10.3
33encephalitis10.3
34scn1b-related generalized epilepsy with febrile seizures plus10.3
35gabrg2-related generalized epilepsy with febrile seizures plus10.3
36gabrd-related generalized epilepsy with febrile seizures plus10.3
37scn9a-related generalized epilepsy with febrile seizures plus10.3
38scn1a- related generalized epilepsy with febrile seizures plus10.3
39scn1a-related simple febrile seizures10.3
40familial mesial temporal lobe epilepsy with febrile seizures10.3
41schizophrenia10.2
42myoclonic epilepsy, infantile, familial10.2
43status epilepticus10.2
44pertussis10.2
45epilepsy, idiopathic generalized10.0SCN1A, GABRG2
46convulsions benign familial neonatal dominant form10.0GABRG2, SCN1B, SCN1A
47frontal lobe epilepsy10.0SCN1A, SCN1B, GABRG2
48insensitivity to pain, congenital, with anhidrosis10.0
49epileptic encephalopathy, early infantile, 2410.0
50epilepsy, childhood absence 210.0

Graphical network of the top 20 diseases related to Febrile Seizures:



Diseases related to febrile seizures

Symptoms for Febrile Seizures

About this section

Drugs & Therapeutics for Febrile Seizures

About this section

Drug clinical trials:

Search ClinicalTrials for Febrile Seizures

Search NIH Clinical Center for Febrile Seizures

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Febrile Seizures

About this section

Genetic tests related to Febrile Seizures:

id Genetic test Affiliating Genes
1 Febrile Seizures22

Anatomical Context for Febrile Seizures

About this section

MalaCards organs/tissues related to Febrile Seizures:

31
Temporal lobe, Brain, Cortex, Testes

Animal Models for Febrile Seizures or affiliated genes

About this section

MGI Mouse Phenotypes related to Febrile Seizures:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.0GABRG2, GABRD, SCN9A, SCN1B, SCN1A, GPR98
2MP:00053867.9GABRG2, GABRD, SCN9A, SCN1B, SCN1A, GPR98
3MP:00036317.7GPR98, SCN1A, SCN1B, SCN9A, GABRD, GABRG2

Publications for Febrile Seizures

About this section

Articles related to Febrile Seizures:

(show top 50)    (show all 553)
idTitleAuthorsYear
1
Erratum to: Recent Advances in Febrile Seizures. (25776001)
2015
2
Febrile seizures in one-five aged infants in tropical practice: Frequency, etiology and outcome of hospitalization. (25878734)
2015
3
Homozygous mutations in the SCN1A gene associated with genetic epilepsy with febrile seizures plus and Dravet syndrome in 2 families. (25795284)
2015
4
Association of IL4 Single-Nucleotide Polymorphisms With Febrile Seizures. (25330798)
2014
5
SCN1A rs3812718 polymorphism and susceptibility to epilepsy with febrile seizures: a meta-analysis. (24076350)
2014
6
Broad Phenotypic Heterogeneity due to a Novel SCN1A Mutation in a Family With Genetic Epilepsy With Febrile Seizures Plus. (24257433)
2014
7
Visualization of different characteristics of cerebrospinal fluid with acute encephalopathy and febrile seizures using pattern recognition analysis of (1)H NMR. (25268146)
2014
8
Prognostic factors for subsequent epilepsy in children with febrile seizures. (24304433)
2013
9
Measles-containing vaccines and febrile seizures in children age 4 to 6 years. (22473362)
2012
10
Febrile seizures after 2010-2011 influenza vaccine in young children, United States: a vaccine safety signal from the vaccine adverse event reporting system. (22361303)
2012
11
Inheritance of febrile seizures in sudden unexplained death in toddlers. (22490769)
2012
12
GABRG2 gene polymorphisms in Egyptian children with simple febrile seizures. (21983990)
2012
13
Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus. (21156207)
2011
14
Top 10 facts you need to know about febrile seizures. (22372159)
2011
15
Replication of association between a SCN1A splice variant and febrile seizures. (21762453)
2011
16
Epileptogenesis after prolonged febrile seizures: mechanisms, biomarkers and therapeutic opportunities. (21356275)
2011
17
Evaluation and management of pediatric febrile seizures in the emergency department. (21109105)
2011
18
Functional variant in complement C3 gene promoter and genetic susceptibility to temporal lobe epilepsy and febrile seizures. (20862287)
2010
19
Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures. (20587679)
2010
20
Novel human pathological mutations. Gene symbol: SCN1A. Disease: generalized epilepsy with febrile seizures plus. (21488303)
2010
21
Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. (20628201)
2010
22
Iron deficiency anaemia--a risk factor for febrile seizures in children. (22338422)
2010
23
The relationship between febrile seizures and epilepsy. (20331712)
2010
24
Altered EEG spectral activity and attentional behavioral deficits following prolonged febrile seizures: a pilot study. (19286493)
2009
25
Febrile seizures: mechanisms and relationship to epilepsy. (19232478)
2009
26
Does a SCN1A gene mutation confer earlier age of onset of febrile seizures in GEFS+? (19292758)
2009
27
Febrile seizures: interleukin 1beta and interleukin-1 receptor antagonist polymorphisms. (19135625)
2009
28
Current explanations regarding febrile seizures provided by pediatricians in Tokyo. (19459906)
2009
29
Interleukin-10 is associated with resistance to febrile seizures: genetic association and experimental animal studies. (19055487)
2009
30
Phenomenology of prolonged febrile seizures: results of the FEBSTAT study. (18525033)
2008
31
Analysis of the GABRG2 gene mutation in a Chinese family with generalized epilepsy with febrile seizures plus]. (19065515)
2008
32
Gene symbol: SCN1A. Disease: Generalized epilepsy with febrile seizures plus. (18846618)
2008
33
Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function. (17629415)
2007
34
Molecular genetics of febrile seizures. (16887333)
2006
35
A novel GABRG2 mutation associated with febrile seizures. (16924025)
2006
36
Febrile seizure, but not hyperthermia alone, induces the expression of heme oxygenase-1 in rat cortex. (16537003)
2006
37
Myoclonic seizures in the context of generalized epilepsy with febrile seizures plus (GEFS+). (15508917)
2005
38
Interleukin-1alpha, interleukin-1beta, and interleukin-1Ra polymorphisms in febrile seizures. (16159520)
2005
39
Febrile seizures. (16333484)
2005
40
Unconsciousness and delirious behavior in children with febrile seizures. (15165632)
2004
41
Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population. (15342122)
2004
42
Febrile seizures and mesial temporal sclerosis. (15021243)
2004
43
The genetics of febrile seizures and related epilepsy syndromes. (12850508)
2003
44
Interleukin-4 intron 3 polymorphism is not related to susceptibility to febrile seizures. (12435565)
2002
45
First place winner. Recurrent febrile seizures: an unusual presentation of nutritional rickets. (12480016)
2002
46
Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. (12040066)
2002
47
Intranasal midazolam effectively treats febrile seizures in children (10884278)
2000
48
Generalized epilepsy with febrile seizures plus: a common childhood-onset genetic epilepsy syndrome. (9894880)
1999
49
Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 in cerebrospinal fluid from children with prolonged febrile seizures. Comparison with acute encephalitis/encephalopathy. (9484363)
1998
50
Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes. (9126059)
1997

Variations for Febrile Seizures

About this section

Expression for genes affiliated with Febrile Seizures

About this section
Search GEO for disease gene expression data for Febrile Seizures.

Pathways for genes affiliated with Febrile Seizures

About this section

Compounds for genes affiliated with Febrile Seizures

About this section

Compounds related to Febrile Seizures according to GeneCards Suite gene sharing:

(show all 38)
idCompoundScoreTop Affiliating Genes
1(+)-bicuculline5910.1GABRD, GABRG2
2(-)-bicuculline methochloride5910.1GABRD, GABRG2
3(-)-bicuculline methiodide5910.1GABRD, GABRG2
4sr 95531 hydrobromide5910.1GABRD, GABRG2
5estazolam43 1211.1GABRD, GABRG2
6quazepam43 1211.1GABRG2, GABRD
7bromazepam43 1211.1GABRD, GABRG2
8lorazepam43 49 1212.1GABRG2, GABRD
9flurazepam43 1211.1GABRG2, GABRD
10oxazepam49 1211.1GABRD, GABRG2
11chlordiazepoxide43 1211.1GABRD, GABRG2
12clonazepam43 1211.0GABRD, GABRG2
13tbps43 2811.0GABRD, GABRG2
14muscimol43 59 2812.0GABRG2, GABRD
15triazolam43 1211.0GABRD, GABRG2
16alprazolam43 1211.0GABRG2, GABRD
17clobazam43 49 1211.9GABRG2, GABRD
18Gamma-Aminobutyric acid249.9GABRD, GABRG2
19midazolam43 49 1211.8GABRG2, GABRD
20diazepam43 28 49 1212.7GABRD, GABRG2
21nitrazepam43 1210.7SCN1A, GABRD, GABRG2
22bc-iii289.5SCN1A, SCN2A
23atx-ii289.5SCN1A, SCN2A
24aft-ii289.5SCN1A, SCN2A
25lamotrigine43 49 1211.5SCN2A, SCN1A
26topiramate43 49 24 1212.5SCN2A, SCN1A
27potassium43 24 1211.4GABRG2, SCN1B, SCN1A
28carbamazepine43 49 1211.1SCN2A, SCN1A
29saxitoxin289.1SCN2A, SCN9A, SCN1A
30batrachotoxin289.1SCN1A, SCN9A, SCN2A
31phenytoin43 49 28 1211.8SCN2A, SCN1A
32phrixotoxin 3598.8SCN2A, SCN1A, SCN1B, SCN9A
33qx 314 chloride598.7SCN1A, SCN1B, SCN9A, SCN2A
34tetrodotoxin citrate598.7SCN1A, SCN1B, SCN9A, SCN2A
35veratridine43 59 2810.7SCN1A, SCN1B, SCN9A, SCN2A
36zonisamide43 49 1210.7SCN1A, SCN1B, SCN9A, SCN2A
37tetrodotoxin43 59 2810.7SCN2A, SCN9A, SCN1B, SCN1A
38sodium43 249.4SCN1A, SCN1B, SCN9A, SCN2A, GABRG2

GO Terms for genes affiliated with Febrile Seizures

About this section

Cellular components related to Febrile Seizures according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chloride channel complexGO:00347079.8GABRG2, GABRD
2node of RanvierGO:00332688.8SCN1A, SCN1B, SCN2A
3T-tubuleGO:00303158.7SCN1A, SCN1B, SCN2A
4intercalated discGO:00147048.5SCN1A, SCN1B, SCN2A
5voltage-gated sodium channel complexGO:00015188.4SCN2A, SCN9A, SCN1B, SCN1A

Biological processes related to Febrile Seizures according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1post-embryonic developmentGO:00097919.7GABRG2, SCN9A
2neuronal action potential propagationGO:00192279.6SCN1A, SCN1B
3neuronal action potentialGO:00192289.4SCN9A, SCN1A
4synaptic transmissionGO:00072689.1GABRG2, GABRD, SCN1B
5sodium ion transportGO:00068148.7SCN2A, SCN9A, SCN1A
6sodium ion transmembrane transportGO:00357258.4SCN2A, SCN9A, SCN1B, SCN1A

Molecular functions related to Febrile Seizures according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chloride channel activityGO:00052549.8GABRG2, GABRD
2GABA-A receptor activityGO:00048909.7GABRD, GABRG2
3extracellular ligand-gated ion channel activityGO:00052309.5GABRG2, GABRD
4voltage-gated sodium channel activityGO:00052488.3SCN2A, SCN9A, SCN1B, SCN1A

Products for genes affiliated with Febrile Seizures

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Febrile Seizures

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet