MCID: FBR031
MIFTS: 49

Febrile Seizures

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Febrile Seizures

MalaCards integrated aliases for Febrile Seizures:

Name: Febrile Seizures 51 29
Febrile Convulsions 69
Seizures Febrile 52

Classifications:



Summaries for Febrile Seizures

NINDS : 51 Febrile seizures are convulsions or seizures  in infants or small children that are brought on by a fever. Most often during a febrile seizure, a child loses consciousness and shakes uncontrollably.  Less commonly, a child becomes rigid or has twitches in only a portion of the body. Most febrile seizures last a minute or two; some can be as brief as a few seconds, while others may last for more than 15 minutes. Approximately one in every 25 children will have at least one febrile seizure.  Febrile seizures usually occur in children between the ages of 6 months and 5 years, with the risk peaking in the second year of life. The older a child is when the first febrile seizure occurs, the less likely that child is to have more.  A few factors appear to boost a child's risk of having recurrent febrile seizures, including young age (less than 18 months) during the first seizures and having immediate family members with a history of febrile seizures.

MalaCards based summary : Febrile Seizures, also known as febrile convulsions, is related to epilepsy, generalized, with febrile seizures plus, type 5 and headache, and has symptoms including fever, seizures and other convulsions. An important gene associated with Febrile Seizures is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways/superpathways are Neuroscience and L1CAM interactions. The drugs Acetaminophen and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and testes, and related phenotypes are behavior/neurological and mortality/aging

Wikipedia : 72 A febrile seizure, also known as a fever fit or febrile convulsion, is a seizure associated with a high... more...

Related Diseases for Febrile Seizures

Diseases in the Febrile Seizures family:

Febrile Seizures, Familial, 3b Febrile Seizures, Familial, 9
Febrile Seizures, Familial, 10 Febrile Seizures, Familial, 4
Febrile Seizures, Familial, 5 Febrile Seizures, Familial, 11
Febrile Seizures, Familial, 1 Febrile Seizures, Familial, 6
Febrile Seizures, Familial, 2 Febrile Seizures, Familial, 7

Diseases related to Febrile Seizures via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
id Related Disease Score Top Affiliating Genes
1 epilepsy, generalized, with febrile seizures plus, type 5 32.1 CHRNA4 CPA6 GABRD GABRG2 SCN1A
2 headache 24.1 ADGRV1 CHRNA4 CPA6 GABRD GABRG2 SCN1A
3 febrile seizures, familial, 3b 12.4
4 epilepsy, generalized, with febrile seizures plus, type 2 12.4
5 epilepsy, generalized, with febrile seizures plus, type 3 12.4
6 generalized epilepsy with febrile seizures plus 12.3
7 epilepsy, generalized, with febrile seizures plus, type 1 12.3
8 febrile seizures, familial, 11 12.3
9 genetic epilepsy with febrile seizures plus 12.3
10 febrile seizures, familial, 4 12.3
11 generalized epilepsy with febrile seizures plus, type 9 12.2
12 febrile seizures, familial, 1 12.2
13 mental retardation, keratoconus, febrile seizures, and sinoatrial block 12.0
14 febrile seizures, familial, 9 11.9
15 febrile seizures, familial, 10 11.9
16 febrile seizures, familial, 5 11.9
17 febrile seizures, familial, 6 11.9
18 febrile seizures, familial, 2 11.9
19 febrile seizures, familial, 7 11.9
20 stx1b-related generalized epilepsy with febrile seizures plus 11.9
21 gabrd-related generalized epilepsy with febrile seizures plus 11.9
22 gabrg2-related generalized epilepsy with febrile seizures plus 11.9
23 scn1b-related generalized epilepsy with febrile seizures plus 11.9
24 scn9a-related generalized epilepsy with febrile seizures plus 11.9
25 scn1a- related generalized epilepsy with febrile seizures plus 11.9
26 scn1a-related simple febrile seizures 11.9
27 epilepsy 11.3
28 epileptic encephalopathy, early infantile, 6 11.2
29 scn1a-related seizure disorders 10.9
30 myoclonic astatic epilepsy 10.9
31 insensitivity to pain, congenital, with anhidrosis 10.7
32 epilepsy idiopathic generalized 8 10.7
33 epilepsy, childhood absence 2 10.7
34 epilepsy, familial temporal lobe, 2 10.7
35 benign familial neonatal epilepsy 10.7
36 chd2 myoclonic encephalopathy 10.7
37 seizure disorder 10.7
38 brugada syndrome 5 10.3 SCN1A SCN1B
39 neuronitis 10.2
40 hereditary xanthinuria 10.2 SCN1A SCN9A
41 temporal lobe epilepsy 10.2
42 influenza 10.2
43 mesomelia-synostoses syndrome 10.2 CPA6 SCN1A
44 encephalopathy 10.1
45 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 10.1 GABRG2 SCN1A
46 familial hypocalciuric hypercalcemia 10.1 GABRG2 SCN9A
47 meningitis 10.1
48 adolescence-adult electroclinical syndrome 10.1 GABRG2 SCN1A SCN1B
49 measles 9.9
50 3-methylcrotonyl-coa carboxylase deficiency 9.9 GABRD GABRG2 SCN1A

Graphical network of the top 20 diseases related to Febrile Seizures:



Diseases related to Febrile Seizures

Symptoms & Phenotypes for Febrile Seizures

UMLS symptoms related to Febrile Seizures:


fever, seizures, other convulsions, seizures, focal, symptomatic seizures

MGI Mouse Phenotypes related to Febrile Seizures:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.81 SCN1A SCN1B SCN9A SEZ6 STX1B ADGRV1
2 mortality/aging MP:0010768 9.56 SCN1A SCN1B SCN9A STX1B ADGRV1 CHRNA4
3 nervous system MP:0003631 9.28 SCN1A SCN1B SCN9A SEZ6 STX1B ADGRV1

Drugs & Therapeutics for Febrile Seizures

Drugs for Febrile Seizures (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
3
Ibuprofen Approved Phase 4 15687-27-1 3672
4
BCG vaccine Investigational Phase 4
5 Analgesics Phase 4
6 Analgesics, Non-Narcotic Phase 4
7 Anti-Inflammatory Agents Phase 4
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4
9 Antipyretics Phase 4
10 Antirheumatic Agents Phase 4
11 Cyclooxygenase Inhibitors Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Vaccines Phase 4,Phase 3,Phase 2
14 Adjuvants, Immunologic Phase 4
15 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2
16
Altretamine Approved Phase 3 645-05-6 2123
17 Antibodies Phase 2
18 Immunoglobulins Phase 2
19 Arginine Vasopressin

Interventional clinical trials:

(show all 20)

id Name Status NCT ID Phase Drugs
1 Antipyretics for Preventing Recurrences of Febrile Seizures Completed NCT00568217 Phase 4 Diclofenac, Paracetamol, Ibuprofen
2 Clinical Immunization Safety Assessment (CISA) Project: Pilot Study to Assess the Effect of Prophylactic Antipyretics on Immune Responses and Fever After IIV Completed NCT01946594 Phase 4
3 The Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine Completed NCT02212990 Phase 4 Acetaminophen Arm;Placebo Arm;Ibuprofen Arm
4 Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children. Completed NCT01694108 Phase 4
5 Fever After Simultaneous Versus Sequential Vaccination in Young Children Recruiting NCT03165981 Phase 4
6 Safety, Tolerability, and Immunogenicity of V419 Given Concomitantly With Prevnar 13™ and RotaTeq™ (V419-005) Completed NCT01337167 Phase 3
7 A Safety and Immune Study of 2 Types of GlaxoSmithKline's Varicella Vaccines Given as a 2-doses Course to Healthy Children 12-23 Months of Age. Completed NCT02570126 Phase 3
8 Safety and Immunogenicity of GSK Biologicals' HPV-16/18 L1 VLP AS04 Vaccine (GSK-580299) in Healthy Female Children 4-6 Years Old Completed NCT01627561 Phase 3
9 Carbon Dioxide (Carbogen) for the Treatment of Febrile Seizures Terminated NCT01370044 Phase 2, Phase 3 Carbogen;Placebo
10 Immunogenicity of GSKs' MMR Vaccine (209762) vs. M-M-R® II, When Given With Routine Vaccines at 12-15 Months of Age Completed NCT00861744 Phase 2
11 Cohorts and Collections: Clinical and Genetic Study of Parkinson's Disease and Epilepsies Terminated NCT00142363 Phase 1
12 Respiratory Physiology in Children With Febrile Seizures. Unknown status NCT01906619
13 Viral Respiratory and Gastrointestinal Infections in Children Under 6 Years of Age Unknown status NCT00987519
14 Nervous System Infections Among Patients With Febrile Seizure Completed NCT01694524
15 The Relevance of Performing Lumbar Puncture in Infants Aged 3 to 12 Months With First Episode of Febrile Convulsion Completed NCT01443611
16 METHORIVAC - Vaccinal Pharmacoepidemiologic Completed NCT01931813
17 Copeptin in Childhood Epilepsy Completed NCT01884766
18 Utility of Laboratory Testing for Children With Seizure in Emergency Department Completed NCT01123746
19 A Surveillance Study of Diseases Specified as Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Children in Africa Prior to Implementation of the RTS,S/AS01E Candidate Vaccine Recruiting NCT02374450
20 Safety Study of Measles-Mumps-Rubella-Varicella (MMRV) Vaccine, Priorix-Tetra™ in Children Living in the Philippines Withdrawn NCT01738841

Search NIH Clinical Center for Febrile Seizures

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Febrile Seizures

Genetic tests related to Febrile Seizures:

id Genetic test Affiliating Genes
1 Febrile Seizures 29

Anatomical Context for Febrile Seizures

MalaCards organs/tissues related to Febrile Seizures:

39
Temporal Lobe, Brain, Testes, Cortex, Kidney

Publications for Febrile Seizures

Articles related to Febrile Seizures:

(show top 50) (show all 649)
id Title Authors Year
1
R-SCAN: Imaging for Pediatric Simple Febrile Seizures. ( 28551342 )
2017
2
The Effect of Quercetin on Pro- and Anti-Inflammatory Cytokines in a Prenatally Stressed Rat Model of Febrile Seizures. ( 28579828 )
2017
3
The assessment of laboratory parameters in children with fever and febrile seizures. ( 28729928 )
2017
4
Identification of two mutations in cis in the SCN1A gene in a family showing genetic epilepsy with febrile seizures plus (GEFS+) and idiopathic generalized epilepsy (IGE). ( 28951233 )
2017
5
The semiology of febrile seizures: Focal features are frequent. ( 28622546 )
2017
6
High Rate of Febrile Seizures in Japanese Children With Occult Bacteremia. ( 28953097 )
2017
7
Early-life febrile seizures worsen adult phenotypes in Scn1a mutants. ( 28373025 )
2017
8
Differences in Mean Platelet Volume and Platelet Count between Children with Simple and Complex Febrile Seizures. ( 28698727 )
2017
9
Long-term white matter tract reorganization following prolonged febrile seizures. ( 28332711 )
2017
10
Evaluation of hippocampal infolding angle and incomplete hippocampal inversion in pediatric patients with epilepsy and febrile seizures. ( 28509667 )
2017
11
Thiol/disulfide homeostasis as a novel indicator of oxidative stress in children with simple febrile seizures. ( 28808794 )
2017
12
DPP4 regulates the inflammatory response in a rat model of febrile seizures. ( 28372289 )
2017
13
Febrile Seizures and Epilepsy: Association With Autism and Other Neurodevelopmental Disorders in the Child and Adolescent Twin Study in Sweden. ( 28754226 )
2017
14
The phenotypic spectrum of ARHGEF9 includes intellectual disability, focal epilepsy and febrile seizures. ( 28620718 )
2017
15
Febrile seizures in children: benefits and risks of prophylactic drug management. ( 28566318 )
2017
16
Genetic epilepsy with febrile seizures plus: Refining the spectrum. ( 28842445 )
2017
17
Mutations in GABRB3: From febrile seizures to epileptic encephalopathies. ( 28053010 )
2017
18
Interleukin-1I^ and interleukin-1receptor antagonist polymorphisms in Egyptian children with febrile seizures: A case-control study. ( 28296777 )
2017
19
Frequency of acute bacterial meningitis in children with first episode of febrile seizures. ( 28770886 )
2017
20
Iron Deficiency Anaemia As Risk Factor For Simple Febrile Seizures: A Case Control Study. ( 28718256 )
2017
21
The assessment of risk factors for febrile seizures in children. ( 28803641 )
2017
22
Vagus nerve stimulation for genetic epilepsy with febrile seizures plus (GEFS(+)) accompanying seizures with impaired consciousness. ( 28070485 )
2017
23
Q10R mutation in SCN9A gene is associated with generalized epilepsy with febrile seizures plus. ( 28704742 )
2017
24
The Role of Human Coronaviruses in Children Hospitalized for Acute Bronchiolitis, Acute Gastroenteritis, and Febrile Seizures: A 2-Year Prospective Study. ( 27171141 )
2016
25
Postnatal steroids and febrile seizures. ( 27435741 )
2016
26
Age of onset of mesial temporal lobe epilepsy with hippocampal sclerosis: the effect of apolipoprotein E and febrile seizures. ( 27875923 )
2016
27
Epilepsy in children with a history of febrile seizures. ( 26958066 )
2016
28
The Effects of Amiloride on Seizure Activity, Cognitive Deficits and Seizure-Induced Neurogenesis in a Novel Rat Model of Febrile Seizures. ( 26700432 )
2016
29
Evaluation of Plasma Melatonin Levels in Children With Afebrile and Febrile Seizures. ( 26851993 )
2016
30
Experimental febrile seizures impair interastrocytic gap junction coupling in juvenile mice. ( 26931373 )
2016
31
Is FGF13 a major contributor to genetic epilepsy with febrile seizures plus? ( 27810516 )
2016
32
Interleukin-6 gene polymorphisms in Egyptian children with febrile seizures: a case-control study. ( 26960986 )
2016
33
Febrile Seizures. ( 26844730 )
2016
34
Serum and CSF adiponectin, leptin, and interleukin 6 levels as adipocytokines in Egyptian children with febrile seizures: a cross-sectional study. ( 27068222 )
2016
35
Generation of Febrile Seizures and Subsequent Epileptogenesis. ( 27562688 )
2016
36
Intermittent Diazepam versus Continuous Phenobarbital to Prevent Recurrence of Febrile Seizures: A Randomized Controlled Trial. ( 27057183 )
2016
37
Childhood Epilepsy, Febrile Seizures, and Subsequent Risk of ADHD. ( 27412639 )
2016
38
New guidelines for management of febrile seizures in Japan. ( 27613077 )
2016
39
Experimental febrile seizures induce age-dependent structural plasticity and improve memory in mice. ( 26794590 )
2016
40
Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures. ( 26875662 )
2016
41
Febrile Seizures in the Era of Rotavirus Vaccine. ( 27199471 )
2016
42
Neonatal hyperbilirubinemia and the risk of febrile seizures and childhood epilepsy. ( 27259071 )
2016
43
The Association Between Plasma Ferritin Level and Simple Febrile Seizures in Children. ( 27467370 )
2016
44
Role of multiplex PCR analysis in children with febrile seizures. ( 27324512 )
2016
45
Urinary kidney injury molecules in children with febrile seizures. ( 27557879 )
2016
46
Zinc supplementation prolongs the latency of hyperthermia-induced febrile seizures in rats. ( 27030634 )
2016
47
Prevalence of Febrile Seizures, Epilepsy, and Other Paroxysmal Attacks in a Swedish Cohort of 4-Year-Old Children. ( 27522228 )
2016
48
Blocking GluN2B subunits reverses the enhanced seizure susceptibility after prolonged febrile seizures with a wide therapeutic time-window. ( 27240522 )
2016
49
Multiplex polymerase chain reaction testing in pediatric inpatients with febrile seizures. ( 27562920 )
2016
50
Neurogenic pulmonary edema combined with febrile seizures in early childhood-A report of two cases. ( 27833858 )
2016

Variations for Febrile Seizures

ClinVar genetic disease variations for Febrile Seizures:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 SCN1A NM_001202435.2(SCN1A): c.327C> G (p.Tyr109Ter) single nucleotide variant Pathogenic GRCh37 Chromosome 2, 166915136: 166915136

Expression for Febrile Seizures

Search GEO for disease gene expression data for Febrile Seizures.

Pathways for Febrile Seizures

Pathways related to Febrile Seizures according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 12.05 SCN1A SCN1B SCN9A
2
Show member pathways
11.53 SCN1A SCN1B SCN9A
3
Show member pathways
11.21 SCN1A SCN1B SCN9A
4 10.73 CHRNA4 GABRD GABRG2
5 10.55 GABRD GABRG2
6 10.28 SCN1A SCN1B SCN9A

GO Terms for Febrile Seizures

Cellular components related to Febrile Seizures according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.97 ADGRV1 CHRNA4 GABRD GABRG2 SCN1A SCN1B
2 plasma membrane GO:0005886 9.81 ADGRV1 CHRNA4 GABRD GABRG2 SCN1A SCN1B
3 neuronal cell body GO:0043025 9.71 CHRNA4 SCN1A SEZ6
4 synapse GO:0045202 9.71 ADGRV1 CHRNA4 GABRD GABRG2
5 postsynaptic membrane GO:0045211 9.61 CHRNA4 GABRD GABRG2
6 axon GO:0030424 9.51 GABRG2 SCN1A
7 chloride channel complex GO:0034707 9.49 GABRD GABRG2
8 intercalated disc GO:0014704 9.48 SCN1A SCN1B
9 T-tubule GO:0030315 9.46 SCN1A SCN1B
10 GABA-A receptor complex GO:1902711 9.37 GABRD GABRG2
11 node of Ranvier GO:0033268 9.26 SCN1A SCN1B
12 sodium channel complex GO:0034706 8.96 SCN1A SCN1B
13 voltage-gated sodium channel complex GO:0001518 8.8 SCN1A SCN1B SCN9A
14 membrane GO:0016020 10.18 ADGRV1 CHRNA4 GABRD GABRG2 SCN1A SCN1B

Biological processes related to Febrile Seizures according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 transport GO:0006810 9.87 CHRNA4 GABRD GABRG2 SCN1A SCN1B SCN9A
2 regulation of ion transmembrane transport GO:0034765 9.67 SCN1A SCN1B SCN9A
3 sodium ion transport GO:0006814 9.65 SCN1A SCN1B SCN9A
4 ion transport GO:0006811 9.63 CHRNA4 GABRD GABRG2 SCN1A SCN1B SCN9A
5 sodium ion transmembrane transport GO:0035725 9.58 SCN1A SCN1B SCN9A
6 excitatory postsynaptic potential GO:0060079 9.56 CHRNA4 SEZ6
7 chemical synaptic transmission GO:0007268 9.56 CHRNA4 GABRD GABRG2 SCN1B
8 sensory perception of pain GO:0019233 9.55 CHRNA4 SCN9A
9 neuronal action potential GO:0019228 9.54 SCN1A SCN9A
10 membrane depolarization during action potential GO:0086010 9.52 SCN1A SCN9A
11 membrane depolarization GO:0051899 9.51 CHRNA4 SCN1B
12 cardiac muscle cell action potential involved in contraction GO:0086002 9.46 SCN1A SCN1B
13 neurological system process GO:0050877 9.43 ADGRV1 CHRNA4
14 neuronal action potential propagation GO:0019227 9.37 SCN1A SCN1B
15 ion transmembrane transport GO:0034220 9.35 CHRNA4 GABRD GABRG2 SCN1A SCN9A
16 regulation of postsynaptic membrane potential GO:0060078 8.92 CHRNA4 SCN1A SCN1B SCN9A

Molecular functions related to Febrile Seizures according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.5 SCN1A SCN1B SCN9A
2 extracellular ligand-gated ion channel activity GO:0005230 9.43 CHRNA4 GABRD GABRG2
3 chloride channel activity GO:0005254 9.4 GABRD GABRG2
4 GABA-A receptor activity GO:0004890 9.37 GABRD GABRG2
5 sodium channel activity GO:0005272 9.33 SCN1A SCN1B SCN9A
6 voltage-gated sodium channel activity GO:0005248 9.13 SCN1A SCN1B SCN9A
7 ion channel activity GO:0005216 8.8 CHRNA4 SCN1A SCN9A

Sources for Febrile Seizures

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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