MCID: FBR031
MIFTS: 53

Febrile Seizures malady

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Febrile Seizures

Aliases & Descriptions for Febrile Seizures:

Name: Febrile Seizures 51 29
Febrile Convulsions 69
Seizures Febrile 52

Classifications:



External Ids:

ICD10 33 R56.0

Summaries for Febrile Seizures

NINDS : 51 Febrile seizures are convulsions or seizures  in infants or small children that are brought on by a fever. Most often during a febrile seizure, a child loses consciousness and shakes uncontrollably.  Less commonly, a child becomes rigid or has twitches in only a portion of the body. Most febrile seizures last a minute or two; some can be as brief as a few seconds, while others may last for more than 15 minutes. Approximately one in every 25 children will have at least one febrile seizure.  Febrile seizures usually occur in children between the ages of 6 months and 5 years, with the risk peaking in the second year of life. The older a child is when the first febrile seizure occurs, the less likely that child is to have more.  A few factors appear to boost a child's risk of having recurrent febrile seizures, including young age (less than 18 months) during the first seizures and having immediate family members with a history of febrile seizures.

MalaCards based summary : Febrile Seizures, also known as febrile convulsions, is related to epilepsy, generalized, with febrile seizures plus, type 5 and early onset absence epilepsy, and has symptoms including fever, seizures and other convulsions. An important gene associated with Febrile Seizures is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways/superpathways are Developmental Biology and G-Beta Gamma Signaling. The drugs Diclofenac and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and cortex, and related phenotypes are behavior/neurological and mortality/aging

Wikipedia : 71 A febrile seizure, also known as a fever fit or febrile convulsion, is a seizure associated with a high... more...

Related Diseases for Febrile Seizures

Diseases in the Febrile Seizures family:

Febrile Seizures, Familial, 3b Febrile Seizures, Familial, 9
Febrile Seizures, Familial, 10 Febrile Seizures, Familial, 4
Febrile Seizures, Familial, 5 Febrile Seizures, Familial, 11
Febrile Seizures, Familial, 1 Febrile Seizures, Familial, 6
Febrile Seizures, Familial, 2 Febrile Seizures, Familial, 7

Diseases related to Febrile Seizures via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
id Related Disease Score Top Affiliating Genes
1 epilepsy, generalized, with febrile seizures plus, type 5 32.8 CHRNA4 CPA6 GABRD GABRG2 SCN1A SCN2A
2 early onset absence epilepsy 28.8 GABRG2 KCNQ2 SCN1A SCN1B SCN2A
3 febrile seizures, familial, 3b 12.4
4 epilepsy, generalized, with febrile seizures plus, type 3 12.4
5 epilepsy, generalized, with febrile seizures plus, type 2 12.4
6 generalized epilepsy with febrile seizures plus 12.4
7 epilepsy, generalized, with febrile seizures plus, type 1 12.3
8 febrile seizures, familial, 11 12.3
9 febrile seizures, familial, 4 12.3
10 generalized epilepsy with febrile seizures plus, type 9 12.2
11 febrile seizures, familial, 1 12.2
12 mental retardation, keratoconus, febrile seizures, and sinoatrial block 12.0
13 febrile seizures, familial, 9 11.9
14 stx1b-related generalized epilepsy with febrile seizures plus 11.9
15 febrile seizures, familial, 7 11.9
16 scn1a- related generalized epilepsy with febrile seizures plus 11.9
17 febrile seizures, familial, 10 11.9
18 febrile seizures, familial, 5 11.9
19 febrile seizures, familial, 6 11.9
20 febrile seizures, familial, 2 11.9
21 scn9a-related generalized epilepsy with febrile seizures plus 11.9
22 scn1a-related simple febrile seizures 11.9
23 gabrd-related generalized epilepsy with febrile seizures plus 11.9
24 gabrg2-related generalized epilepsy with febrile seizures plus 11.9
25 scn1b-related generalized epilepsy with febrile seizures plus 11.9
26 dravet syndrome 11.5
27 epilepsy 11.3
28 scn1a-related seizure disorders 10.9
29 epilepsy idiopathic generalized 8 10.7
30 chd2 myoclonic encephalopathy 10.7
31 seizure disorder 10.7
32 epilepsy, childhood absence 2 10.7
33 epilepsy, familial temporal lobe, 2 10.7
34 insensitivity to pain, congenital, with anhidrosis 10.7
35 neuronitis 10.2
36 atrial fibrillation, familial, 13 10.2 SCN1A SCN1B
37 familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis 10.2 GABRG2 SCN1A
38 temporal lobe epilepsy 10.2
39 influenza 10.2
40 scn5a-related brugada syndrome 10.2 SCN1B SCN9A
41 gingivitis 10.1 GABRG2 SCN1A SCN1B
42 aceruloplasminemia 10.1 GABRD GABRG2 SCN1A
43 encephalopathy 10.1
44 syne1-related autosomal recessive cerebellar ataxia 10.1 SCN1A SCN1B SCN9A
45 adult brain ependymoma 10.1 SCN1A SCN2A
46 meningitis 10.0
47 urethral stricture 10.0 CHRNA4 GABRG2 SCN1B
48 wagro syndrome 9.9 GABRG2 KCNQ2
49 autosomal recessive nonsyndromic deafness 9.9 GABRG2 KCNQ2 SCN1A
50 3-methylcrotonyl-coa carboxylase deficiency 9.9 GABRG2 KCNQ2

Graphical network of the top 20 diseases related to Febrile Seizures:



Diseases related to Febrile Seizures

Symptoms & Phenotypes for Febrile Seizures

UMLS symptoms related to Febrile Seizures:


fever, seizures, other convulsions, seizures, focal, symptomatic seizures

MGI Mouse Phenotypes related to Febrile Seizures:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.9 KCNQ2 SCN1A SCN1B SCN2A SCN9A SEZ6
2 mortality/aging MP:0010768 9.65 GABRG2 KCNQ2 SCN1A SCN1B SCN2A SCN9A
3 nervous system MP:0003631 9.36 KCNQ2 SCN1A SCN1B SCN2A SCN9A SEZ6

Drugs & Therapeutics for Febrile Seizures

Drugs for Febrile Seizures (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 109)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
2
Acetaminophen Approved Phase 4,Phase 3,Phase 2 103-90-2 1983
3
Ibuprofen Approved Phase 4 15687-27-1 3672
4
Sulfadiazine Approved, Vet_approved Phase 4 68-35-9 5215
5
Sulfamethoxazole Approved Phase 4 723-46-6 5329
6
Pyrimethamine Approved, Vet_approved Phase 4 58-14-0 4993
7
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
8
Lumefantrine Approved Phase 4 82186-77-4 6437380
9
leucovorin Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-05-9 54575, 6560146 143
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Analgesics Phase 4,Phase 3,Phase 2
13 Adjuvants, Immunologic Phase 4,Phase 1,Phase 2
14 Folic Acid Antagonists Phase 4,Phase 1,Phase 2
15 Cyclooxygenase Inhibitors Phase 4
16 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2
17 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
18 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
19 Vaccines Phase 4,Phase 3,Phase 2
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
21 Vitamin B Complex Phase 4,Phase 1,Phase 2
22 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
23 Anti-Inflammatory Agents Phase 4
24 Antimalarials Phase 4
25 Anti-Inflammatory Agents, Non-Steroidal Phase 4
26 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
27 Antipyretics Phase 4,Phase 3,Phase 2
28 Antirheumatic Agents Phase 4,Phase 1,Phase 2
29 BCG Vaccine Phase 4
30 Antiparasitic Agents Phase 4
31 Antiprotozoal Agents Phase 4
32 Folate Nutraceutical Phase 4,Phase 1,Phase 2
33 Vitamin B9 Nutraceutical Phase 4,Phase 1,Phase 2
34
Glycerol Approved, Experimental Phase 3 56-81-5 753
35
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
36
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354
37 Trace Elements Phase 3
38 Vitamins Phase 3
39 Immunoglobulins Phase 3,Phase 1,Phase 2
40 gamma-Globulins Phase 3,Phase 1,Phase 2
41 Immunoglobulins, Intravenous Phase 3,Phase 1,Phase 2
42 Rho(D) Immune Globulin Phase 3,Phase 1,Phase 2
43 Antibodies Phase 3,Phase 1,Phase 2
44 Micronutrients Phase 3
45 Sodium Channel Blockers Phase 2, Phase 3,Phase 1
46 Diuretics, Potassium Sparing Phase 2, Phase 3,Phase 1
47 Protective Agents Phase 3
48 Retinol palmitate Phase 3
49 Antioxidants Phase 3
50 Immunoglobulin G Phase 3

Interventional clinical trials:

(show top 50) (show all 51)
id Name Status NCT ID Phase
1 Antipyretics for Preventing Recurrences of Febrile Seizures Completed NCT00568217 Phase 4
2 Clinical Immunization Safety Assessment (CISA) Project: Pilot Study to Assess the Effect of Prophylactic Antipyretics on Immune Responses and Fever After IIV Completed NCT01946594 Phase 4
3 The Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine Completed NCT02212990 Phase 4
4 Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children. Completed NCT01694108 Phase 4
5 Introduction of Hypo-osmolar ORS for Routine Use Completed NCT00244777 Phase 4
6 Home Management of Malaria and Pneumonia Completed NCT02151578 Phase 4
7 Treatment of Cerebral Toxoplasmosis in HIV/AIDS Completed NCT00367081 Phase 4
8 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
9 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
10 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part II Recruiting NCT01604421 Phase 4
11 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part I Recruiting NCT01604317 Phase 4
12 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part III Recruiting NCT01604434 Phase 4
13 Fever After Simultaneous Versus Sequential Vaccination in Young Children Not yet recruiting NCT03165981 Phase 4
14 Safety, Tolerability, and Immunogenicity of V419 Given Concomitantly With Prevnar 13™ and RotaTeq™ (V419-005) Completed NCT01337167 Phase 3
15 Safety and Immunogenicity of GSK Biologicals' HPV-16/18 L1 VLP AS04 Vaccine (GSK-580299) in Healthy Female Children 4-6 Years Old Completed NCT01627561 Phase 3
16 Indiaclen Short Course Amoxycillin Therapy for Pneumonia With Wheeze Completed NCT00407394 Phase 3
17 Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis Completed NCT00619203 Phase 3
18 Immunogenicity and Safety of GSK Biologicals' Combined Measles-mumps-rubella Vaccine in Volunteers, Seven Years of Age and Older Completed NCT02058563 Phase 3
19 Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Given at 6, 7.5 and 9 Months of Age in Co-administration With Measles, Rubella and Yellow Fever (YF) Vaccines Followed by a Booster of the Malaria Vaccine. Recruiting NCT02699099 Phase 3
20 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Recruiting NCT01376778 Phase 3
21 Carbon Dioxide (Carbogen) for the Treatment of Febrile Seizures Terminated NCT01370044 Phase 2, Phase 3
22 Clinical Study to Assess Efficacy and Safety of Amiodarone in Treating Patients With Ebola. Virus Disease (EVD) in Sierra Leone. EASE (EMERGENCY Amiodarone Study Against Ebola) Withdrawn NCT02307591 Phase 2, Phase 3
23 Treatment of Japanese Encephalitis Unknown status NCT00216268 Phase 2
24 Clinical Evaluation of Anti-CHIKV Hyperimmune Intravenous Immunoglobulins Unknown status NCT02230163 Phase 1, Phase 2
25 Immunogenicity of GSKs' MMR Vaccine (209762) vs. M-M-R® II, When Given With Routine Vaccines at 12-15 Months of Age Completed NCT00861744 Phase 2
26 Sirolimus in Treating Patients With Glioblastoma Multiforme Completed NCT00047073 Phase 1, Phase 2
27 Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer Completed NCT00245037 Phase 1, Phase 2
28 Reduction of Intrapartum Fever With Intravenous Acetaminophen Recruiting NCT02625454 Phase 2
29 Safety of Autologous MSC Infusion to Treat Epilepsy Suspended NCT02497443 Phase 1, Phase 2
30 Cohorts and Collections: Clinical and Genetic Study of Parkinson's Disease and Epilepsies Terminated NCT00142363 Phase 1
31 Respiratory Physiology in Children With Febrile Seizures. Unknown status NCT01906619
32 Viral Respiratory and Gastrointestinal Infections in Children Under 6 Years of Age Unknown status NCT00987519
33 Treatment of Iron Deficiency Anemia in Malaria Endemic Ghana Unknown status NCT01001871
34 Nervous System Infections Among Patients With Febrile Seizure Completed NCT01694524
35 The Relevance of Performing Lumbar Puncture in Infants Aged 3 to 12 Months With First Episode of Febrile Convulsion Completed NCT01443611
36 METHORIVAC - Vaccinal Pharmacoepidemiologic Completed NCT01931813
37 Utility of Laboratory Testing for Children With Seizure in Emergency Department Completed NCT01123746
38 Post-marketing Safety Study of GSK Biological's Pediarix™ Vaccine Completed NCT00146835
39 Efficacy of Newborn Vitamin A Supplementation Versus Placebo in Improving Child Survival (NeoVitA Trial) Completed NCT01138449
40 A Surveillance Study of Diseases Specified as Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Children in Africa Prior to Implementation of the RTS,S/AS01E Candidate Vaccine Recruiting NCT02374450
41 Acute Phase Reactions and Thrombophilia in Pediatric Patients With Migraine Recruiting NCT01905748
42 A Perspective Study of Cancer-related Fatigue in Gynecologic Cancer Patients Under Chemotherapy Recruiting NCT03089892
43 Targeted Temperature Management After In-Hospital Cardiac Arrest Recruiting NCT02578823
44 A Pilot Study to Identify Biomarkers Associated With Chronic Traumatic Brain Injury Recruiting NCT01171131
45 Kangaroo Mother Care to Prevent Hypothermia in Preterm Infants Recruiting NCT02189746
46 Kangaroo Mother Care With Plastic Bag (Trials 2A & 2B) Recruiting NCT03141723
47 Kangaroo Mother Care With Plastic Bag (Trials 1A & 1B) Recruiting NCT03141736
48 Copeptin in Childhood Epilepsy Active, not recruiting NCT01884766
49 Kangaroo Mother Care to Prevent Hypothermia in Term Infants Active, not recruiting NCT02189759
50 Primary Prevention of Peristomial Hernias Via Parietal Prostheses Active, not recruiting NCT01380860

Search NIH Clinical Center for Febrile Seizures

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Febrile Seizures

Genetic tests related to Febrile Seizures:

id Genetic test Affiliating Genes
1 Febrile Seizures 29

Anatomical Context for Febrile Seizures

MalaCards organs/tissues related to Febrile Seizures:

39
Temporal Lobe, Brain, Cortex, Testes, Kidney

Publications for Febrile Seizures

Articles related to Febrile Seizures:

(show top 50) (show all 626)
id Title Authors Year
1
Interleukin-1I^ and interleukin-1receptor antagonist polymorphisms in Egyptian children with febrile seizures: A case-control study. ( 28296777 )
2017
2
Interleukin-6 gene polymorphisms in Egyptian children with febrile seizures: a case-control study. ( 26960986 )
2016
3
Experimental febrile seizures increase dendritic complexity of newborn dentate granule cells. ( 27020476 )
2016
4
Experimental febrile seizures impair interastrocytic gap junction coupling in juvenile mice. ( 26931373 )
2016
5
Prevalence of Febrile Seizures, Epilepsy, and Other Paroxysmal Attacks in a Swedish Cohort of 4-Year-Old Children. ( 27522228 )
2016
6
Role of multiplex PCR analysis in children with febrile seizures. ( 27324512 )
2016
7
Generation of Febrile Seizures and Subsequent Epileptogenesis. ( 27562688 )
2016
8
Serum and CSF adiponectin, leptin, and interleukin 6 levels as adipocytokines in Egyptian children with febrile seizures: a cross-sectional study. ( 27068222 )
2016
9
New guidelines for management of febrile seizures in Japan. ( 27613077 )
2016
10
The Effects of Amiloride on Seizure Activity, Cognitive Deficits and Seizure-Induced Neurogenesis in a Novel Rat Model of Febrile Seizures. ( 26700432 )
2016
11
Intermittent Diazepam versus Continuous Phenobarbital to Prevent Recurrence of Febrile Seizures: A Randomized Controlled Trial. ( 27057183 )
2016
12
Transient increase of interleukin-1I^ after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling. ( 26902320 )
2016
13
Childhood Epilepsy, Febrile Seizures, and Subsequent Risk of ADHD. ( 27412639 )
2016
14
Risk factors for subsequent febrile seizures in the FEBSTAT study. ( 27265870 )
2016
15
Febrile Seizures in the Era of Rotavirus Vaccine. ( 27199471 )
2016
16
Distinguishing Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion from Prolonged Febrile Seizures by Acute Phase EEG Spectrum Analysis. ( 27046946 )
2016
17
Neonatal hyperbilirubinemia and the risk of febrile seizures and childhood epilepsy. ( 27259071 )
2016
18
Epilepsy in children with a history of febrile seizures. ( 26958066 )
2016
19
Urinary kidney injury molecules in children with febrile seizures. ( 27557879 )
2016
20
Multiplex polymerase chain reaction testing in pediatric inpatients with febrile seizures. ( 27562920 )
2016
21
Evaluation of Plasma Melatonin Levels in Children With Afebrile and Febrile Seizures. ( 26851993 )
2016
22
Experimental febrile seizures induce age-dependent structural plasticity and improve memory in mice. ( 26794590 )
2016
23
Postnatal steroids and febrile seizures. ( 27435741 )
2016
24
Blocking GluN2B subunits reverses the enhanced seizure susceptibility after prolonged febrile seizures with a wide therapeutic time-window. ( 27240522 )
2016
25
Vaccines and Febrile Seizures: Quantifying the Risk. ( 27273713 )
2016
26
Neurogenic pulmonary edema combined with febrile seizures in early childhood-A report of two cases. ( 27833858 )
2016
27
Febrile Seizures. ( 26844730 )
2016
28
Zinc supplementation prolongs the latency of hyperthermia-induced febrile seizures in rats. ( 27030634 )
2016
29
Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures. ( 26875662 )
2016
30
The Role of Human Coronaviruses in Children Hospitalized for Acute Bronchiolitis, Acute Gastroenteritis, and Febrile Seizures: A 2-Year Prospective Study. ( 27171141 )
2016
31
The Association Between Plasma Ferritin Level and Simple Febrile Seizures in Children. ( 27467370 )
2016
32
Age of onset of mesial temporal lobe epilepsy with hippocampal sclerosis: the effect of apolipoprotein E and febrile seizures. ( 27875923 )
2016
33
Febrile seizures in 1-5 aged infants in tropical practice: Frequency, etiology and outcome of hospitalization. ( 26962364 )
2015
34
Single nucleotide polymorphisms of TNF-I9 gene in febrile seizures. ( 26119396 )
2015
35
Cortical alterations in a model for absence epilepsy and febrile seizures: In vivo findings in mice carrying a human GABA(A)R gamma2 subunit mutation. ( 25731747 )
2015
36
Homozygous mutations in the SCN1A gene associated with genetic epilepsy with febrile seizures plus and Dravet syndrome in 2 families. ( 25795284 )
2015
37
Long-term neurocognitive outcome and auditory event-related potentials after complex febrile seizures in children. ( 26043164 )
2015
38
Possible role of trace elements in epilepsy and febrile seizures: a meta-analysis. ( 26433016 )
2015
39
Febrile seizures in children with familial Mediterranean fever: Coincidence or association? ( 26028444 )
2015
40
The Genetics of Febrile Seizures. ( 26933546 )
2015
41
Febrile Seizures After 2010-2011 Trivalent Inactivated Influenza Vaccine. ( 26371192 )
2015
42
Emergency Department Evaluation and Management of Children With Simple Febrile Seizures. ( 25667312 )
2015
43
Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures. ( 26311622 )
2015
44
Community-based prevalence and clinical characteristics of febrile seizures in Tanzania. ( 25580743 )
2015
45
Risk of Bacterial Meningitis in Children 6 to 11 Months of Age With a First Simple Febrile Seizure: A Retrospective, Cross-sectional, Observational Study. ( 26468690 )
2015
46
Searsia chirindensis reverses the potentiating effect of prenatal stress on the development of febrile seizures and decreased plasma interleukin-1I^ levels. ( 26320878 )
2015
47
Protective effect of carnosine on febrile seizures in immature mice. ( 25562630 )
2015
48
Hippocampal Malrotation Is Associated With Prolonged Febrile Seizures: Results of the FEBSTAT Study. ( 26496555 )
2015
49
TRPV1 promotes repetitive febrile seizures by pro-inflammatory cytokines in immature brain. ( 25801060 )
2015
50
Association between iron deficiency and febrile seizures. ( 26112262 )
2015

Variations for Febrile Seizures

Expression for Febrile Seizures

Search GEO for disease gene expression data for Febrile Seizures.

Pathways for Febrile Seizures

Pathways related to Febrile Seizures according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 KCNQ2 SCN1A SCN1B SCN2A SCN9A STX1B
2
Show member pathways
12.54 SCN1A SCN1B SCN2A SCN9A
3
Show member pathways
12.49 SCN1A SCN1B SCN2A SCN9A
4
Show member pathways
12.3 SCN1A SCN1B SCN2A SCN9A
5 12.17 KCNQ2 SCN1A SCN1B SCN2A SCN9A
6
Show member pathways
11.45 KCNQ2 SCN1A SCN1B SCN2A SCN9A
7
Show member pathways
11.33 SCN1A SCN1B SCN2A SCN9A
8 11.1 CHRNA4 GABRD GABRG2
9 10.6 GABRD GABRG2
10 10.5 KCNQ2 SCN1A SCN1B SCN2A SCN9A

GO Terms for Febrile Seizures

Cellular components related to Febrile Seizures according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 9.8 ADGRV1 CHRNA4 GABRD GABRG2
2 postsynaptic membrane GO:0045211 9.69 CHRNA4 GABRD GABRG2
3 intercalated disc GO:0014704 9.58 SCN1A SCN1B SCN2A
4 chloride channel complex GO:0034707 9.52 GABRD GABRG2
5 T-tubule GO:0030315 9.5 SCN1A SCN1B SCN2A
6 GABA-A receptor complex GO:1902711 9.46 GABRD GABRG2
7 axon initial segment GO:0043194 9.43 KCNQ2 SCN1A
8 sodium channel complex GO:0034706 9.33 SCN1A SCN1B SCN2A
9 node of Ranvier GO:0033268 9.26 KCNQ2 SCN1A SCN1B SCN2A
10 voltage-gated sodium channel complex GO:0001518 8.92 SCN1A SCN1B SCN2A SCN9A
11 membrane GO:0016020 10.22 ADGRV1 CHRNA4 GABRD GABRG2 KCNQ2 SCN1A
12 integral component of membrane GO:0016021 10.11 ADGRV1 CHRNA4 GABRD GABRG2 KCNQ2 SCN1A
13 plasma membrane GO:0005886 10 ADGRV1 CHRNA4 GABRD GABRG2 KCNQ2 SCN1A

Biological processes related to Febrile Seizures according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 transport GO:0006810 9.97 CHRNA4 GABRD GABRG2 KCNQ2 SCN1A SCN1B
2 transmembrane transport GO:0055085 9.85 KCNQ2 SCN1A SCN2A SCN9A
3 sodium ion transport GO:0006814 9.78 SCN1A SCN1B SCN2A SCN9A
4 chemical synaptic transmission GO:0007268 9.77 CHRNA4 GABRD GABRG2 KCNQ2 SCN1B
5 ion transport GO:0006811 9.76 CHRNA4 GABRD GABRG2 KCNQ2 SCN1A SCN1B
6 sodium ion transmembrane transport GO:0035725 9.71 SCN1A SCN1B SCN2A SCN9A
7 regulation of ion transmembrane transport GO:0034765 9.65 KCNQ2 SCN1A SCN1B SCN2A SCN9A
8 neuronal action potential GO:0019228 9.63 SCN1A SCN2A SCN9A
9 membrane depolarization during action potential GO:0086010 9.61 SCN1A SCN2A SCN9A
10 membrane depolarization GO:0051899 9.54 CHRNA4 SCN1B
11 cardiac muscle cell action potential involved in contraction GO:0086002 9.52 SCN1A SCN1B
12 neurological system process GO:0050877 9.51 ADGRV1 CHRNA4
13 neuronal action potential propagation GO:0019227 9.49 SCN1A SCN1B
14 regulation of postsynaptic membrane potential GO:0060078 9.35 CHRNA4 SCN1A SCN1B SCN2A SCN9A
15 ion transmembrane transport GO:0034220 9.17 CHRNA4 GABRD GABRG2 KCNQ2 SCN1A SCN2A

Molecular functions related to Febrile Seizures according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.56 CHRNA4 SCN1A SCN2A SCN9A
2 voltage-gated ion channel activity GO:0005244 9.55 KCNQ2 SCN1A SCN1B SCN2A SCN9A
3 extracellular ligand-gated ion channel activity GO:0005230 9.5 CHRNA4 GABRD GABRG2
4 GABA-A receptor activity GO:0004890 9.37 GABRD GABRG2
5 sodium channel activity GO:0005272 9.26 SCN1A SCN1B SCN2A SCN9A
6 voltage-gated sodium channel activity GO:0005248 8.92 SCN1A SCN1B SCN2A SCN9A

Sources for Febrile Seizures

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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