MCID: FBR031
MIFTS: 52

Febrile Seizures

Categories: Rare diseases, Neuronal diseases, Genetic diseases

Aliases & Classifications for Febrile Seizures

MalaCards integrated aliases for Febrile Seizures:

Name: Febrile Seizures 50 36 28
Febrile Convulsions 69
Seizures Febrile 51

Classifications:



External Ids:

KEGG 36 H00783
ICD10 32 R56.0
UMLS 69 C0009952

Summaries for Febrile Seizures

NINDS : 50 Febrile seizures are convulsions or seizures  in infants or small children that are brought on by a fever. Most often during a febrile seizure, a child loses consciousness and shakes uncontrollably.  Less commonly, a child becomes rigid or has twitches in only a portion of the body. Most febrile seizures last a minute or two; some can be as brief as a few seconds, while others may last for more than 15 minutes. Approximately one in every 25 children will have at least one febrile seizure.  Febrile seizures usually occur in children between the ages of 6 months and 5 years, with the risk peaking in the second year of life. The older a child is when the first febrile seizure occurs, the less likely that child is to have more.  A few factors appear to boost a child's risk of having recurrent febrile seizures, including young age (less than 18 months) during the first seizures and having immediate family members with a history of febrile seizures.

MalaCards based summary : Febrile Seizures, also known as febrile convulsions, is related to febrile seizures, familial, 11 and genetic epilepsy with febrile seizures plus, and has symptoms including symptomatic seizures, other convulsions and seizures. An important gene associated with Febrile Seizures is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways/superpathways are Dopaminergic synapse and Neuroactive ligand-receptor interaction. The drugs Diclofenac and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and cortex, and related phenotypes are behavior/neurological and mortality/aging

Related Diseases for Febrile Seizures

Diseases in the Febrile Seizures family:

Febrile Seizures, Familial, 1 Febrile Seizures, Familial, 2
Febrile Seizures, Familial, 4 Febrile Seizures, Familial, 6
Febrile Seizures, Familial, 5 Febrile Seizures, Familial, 7
Febrile Seizures, Familial, 9 Febrile Seizures, Familial, 10
Febrile Seizures, Familial, 11

Diseases related to Febrile Seizures via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 febrile seizures, familial, 11 34.0 CPA6 SCN1A
2 genetic epilepsy with febrile seizures plus 33.9 SCN1A SCN9A
3 generalized epilepsy with febrile seizures plus, type 1 33.9 SCN1A SCN1B
4 epilepsy, idiopathic generalized 10 32.1 CHRNA4 CPA6 GABRD GABRG2 SCN1A
5 generalized epilepsy with febrile seizures plus 31.6 ADGRV1 GABRD GABRG2 SCN1A SCN1B SCN9A
6 epileptic encephalopathy, early infantile, 6 31.6 GABRD GABRG2 SCN1A SCN1B SCN9A
7 epilepsy 30.1 CHRNA4 CPA6 GABRD GABRG2 SCN1A SCN1B
8 myoclonic epilepsy of infancy 29.9 GABRG2 SCN1A
9 childhood absence epilepsy 29.5 CHRNA4 GABRG2 SCN1B
10 focal epilepsy 28.9 CHRNA4 CPA6 GABRD GABRG2 SCN1A
11 epilepsy, idiopathic generalized 28.7 CHRNA4 GABRD GABRG2 SCN1A SCN1B
12 generalized epilepsy with febrile seizures plus, type 2 12.6
13 generalized epilepsy with febrile seizures plus, type 7 12.5
14 generalized epilepsy with febrile seizures plus, type 3 12.5
15 febrile seizures, familial, 4 12.5
16 febrile seizures, familial, 1 12.4
17 generalized epilepsy with febrile seizures plus, type 9 12.3
18 generalized epilepsy with febrile seizures plus, type 8 12.3
19 mental retardation, keratoconus, febrile seizures, and sinoatrial block 12.2
20 generalized epilepsy with febrile seizures plus, type 6 12.1
21 generalized epilepsy with febrile seizures plus, type 4 12.1
22 febrile seizures, familial, 7 12.1
23 febrile seizures, familial, 2 12.1
24 febrile seizures, familial, 9 12.1
25 febrile seizures, familial, 10 12.1
26 febrile seizures, familial, 6 12.1
27 febrile seizures, familial, 5 12.1
28 epilepsy, familial temporal lobe, 2 11.2
29 scn1a-related seizure disorders 11.0
30 myoclonic astatic epilepsy 11.0
31 seizure disorder 10.8
32 epilepsy, idiopathic generalized 8 10.8
33 benign familial neonatal epilepsy 10.8
34 exanthema subitum 10.8
35 epilepsy, childhood absence 2 10.8
36 chd2 myoclonic encephalopathy 10.8
37 insensitivity to pain, congenital, with anhidrosis 10.8
38 skraban-deardorff syndrome 10.8
39 neuronitis 10.3
40 temporal lobe epilepsy 10.3
41 influenza 10.3
42 encephalopathy 10.2
43 aging 10.2
44 iron metabolism disease 10.2
45 meningitis 10.1
46 ring chromosome y syndrome 10.1
47 infancy electroclinical syndrome 10.0 GABRG2 SCN1A SCN1B
48 deficiency anemia 10.0
49 measles 10.0
50 iron deficiency anemia 10.0

Graphical network of the top 20 diseases related to Febrile Seizures:



Diseases related to Febrile Seizures

Symptoms & Phenotypes for Febrile Seizures

UMLS symptoms related to Febrile Seizures:


symptomatic seizures, other convulsions, seizures, fever

MGI Mouse Phenotypes related to Febrile Seizures:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.81 ADGRV1 CHRNA4 GABRD GABRG2 SCN1A SCN1B
2 mortality/aging MP:0010768 9.56 ADGRV1 CHRNA4 GABRD GABRG2 SCN1A SCN1B
3 nervous system MP:0003631 9.28 GABRG2 SCN1A SCN1B SCN9A SEZ6 STX1B

Drugs & Therapeutics for Febrile Seizures

Drugs for Febrile Seizures (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Ibuprofen Approved Phase 4 15687-27-1 3672
4
BCG vaccine Investigational Phase 4
5 Analgesics Phase 4
6 Adjuvants, Immunologic Phase 4
7 Cyclooxygenase Inhibitors Phase 4
8 Analgesics, Non-Narcotic Phase 4
9 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2
10 Vaccines Phase 4,Phase 3,Phase 2
11 Peripheral Nervous System Agents Phase 4
12 Anti-Inflammatory Agents Phase 4
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4
14 Antipyretics Phase 4
15 Antirheumatic Agents Phase 4
16
Altretamine Approved Phase 3 645-05-6 2123
17 Immunoglobulins Phase 2
18 Antibodies Phase 2
19 Arginine Vasopressin

Interventional clinical trials:

(show all 19)

# Name Status NCT ID Phase Drugs
1 Antipyretics for Preventing Recurrences of Febrile Seizures Completed NCT00568217 Phase 4 Diclofenac, Paracetamol, Ibuprofen
2 Clinical Immunization Safety Assessment (CISA) Project: Pilot Study to Assess the Effect of Prophylactic Antipyretics on Immune Responses and Fever After IIV Completed NCT01946594 Phase 4
3 Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children. Completed NCT01694108 Phase 4
4 Fever After Simultaneous Versus Sequential Vaccination in Young Children Recruiting NCT03165981 Phase 4
5 Safety, Tolerability, and Immunogenicity of V419 Given Concomitantly With Prevnar 13™ and RotaTeq™ (V419-005) Completed NCT01337167 Phase 3
6 A Safety and Immune Study of 2 Types of GlaxoSmithKline's Varicella Vaccines Given as a 2-doses Course to Healthy Children 12-23 Months of Age. Completed NCT02570126 Phase 3
7 Safety and Immunogenicity of GSK Biologicals' HPV-16/18 L1 VLP AS04 Vaccine (GSK-580299) in Healthy Female Children 4-6 Years Old Completed NCT01627561 Phase 3
8 Carbon Dioxide (Carbogen) for the Treatment of Febrile Seizures Terminated NCT01370044 Phase 2, Phase 3 Carbogen;Placebo
9 Immunogenicity of GSKs' MMR Vaccine (209762) vs. M-M-R® II, When Given With Routine Vaccines at 12-15 Months of Age Completed NCT00861744 Phase 2
10 Cohorts and Collections: Clinical and Genetic Study of Parkinson's Disease and Epilepsies Terminated NCT00142363 Phase 1
11 Respiratory Physiology in Children With Febrile Seizures. Unknown status NCT01906619
12 Viral Respiratory and Gastrointestinal Infections in Children Under 6 Years of Age Unknown status NCT00987519
13 Nervous System Infections Among Patients With Febrile Seizure Completed NCT01694524
14 The Relevance of Performing Lumbar Puncture in Infants Aged 3 to 12 Months With First Episode of Febrile Convulsion Completed NCT01443611
15 METHORIVAC - Vaccinal Pharmacoepidemiologic Completed NCT01931813
16 Copeptin in Childhood Epilepsy Completed NCT01884766
17 The Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine Completed NCT02212990
18 A Surveillance Study of Diseases Specified as Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Children in Africa Prior to Implementation of the RTS,S/AS01E Candidate Recruiting NCT02374450
19 Safety Study of Measles-Mumps-Rubella-Varicella (MMRV) Vaccine, Priorix-Tetra™ in Children Living in the Philippines Withdrawn NCT01738841

Search NIH Clinical Center for Febrile Seizures

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Febrile Seizures

Genetic tests related to Febrile Seizures:

# Genetic test Affiliating Genes
1 Febrile Seizures 28

Anatomical Context for Febrile Seizures

MalaCards organs/tissues related to Febrile Seizures:

38
Temporal Lobe, Brain, Cortex, Testes, Kidney

Publications for Febrile Seizures

Articles related to Febrile Seizures:

(show top 50) (show all 667)
# Title Authors Year
1
Differential roles of Na<sub>V</sub>1.2 and Na<sub>V</sub>1.6 in regulating neuronal excitability at febrile temperature and distinct contributions to febrile seizures. ( 29335582 )
2018
2
Yonder: Sleep quality, febrile seizures, interpreters, and doulas. ( 29371306 )
2018
3
DYRK1A-haploinsufficiency in mice causes autistic-like features and febrile seizures. ( 29223763 )
2018
4
Parent's Experiences of Their Children Suffering Febrile Seizures. ( 29167084 )
2018
5
Serum IL-6 Levels in Children with Febrile Seizures. ( 29428914 )
2018
6
Temporal analysis of hippocampal CA3 gene coexpression networks in a rat model of febrile seizures. ( 29196444 )
2018
7
Stress and Corticosteroids Aggravate Morphological Changes in the Dentate Gyrus after Early-Life Experimental Febrile Seizures in Mice. ( 29434572 )
2018
8
GABRG2 C588T gene polymorphisms might be a predictive genetic marker of febrile seizures and generalized recurrent seizures: a case-control study in a Romanian pediatric population. ( 29379546 )
2018
9
Correction to: Analysis of plasma multiplex cytokines and increased level of IL-10 and IL-1Ra cytokines in febrile seizures. ( 29149888 )
2017
10
Chiari 1 Malformation in a Child with Febrile Seizures, Parasomnias, and Sleep Apnea Syndrome. ( 29391961 )
2017
11
High Rate of Febrile Seizures in Japanese Children With Occult Bacteremia. ( 28953097 )
2017
12
The phenotypic spectrum of ARHGEF9 includes intellectual disability, focal epilepsy and febrile seizures. ( 28620718 )
2017
13
Q10R mutation in SCN9A gene is associated with generalized epilepsy with febrile seizures plus. ( 28704742 )
2017
14
Correction to: Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures. ( 29185186 )
2017
15
Mutations in GABRB3: From febrile seizures to epileptic encephalopathies. ( 28053010 )
2017
16
Interleukin-1I^ and interleukin-1receptor antagonist polymorphisms in Egyptian children with febrile seizures: A case-control study. ( 28296777 )
2017
17
Iron Deficiency Anaemia As Risk Factor For Simple Febrile Seizures: A Case Control Study. ( 28718256 )
2017
18
Febrile seizures in children: benefits and risks of prophylactic drug management. ( 28566318 )
2017
19
Motor cortex excitability in seizure-free STX1B mutation carriers with a history of epilepsy and febrile seizures. ( 29101845 )
2017
20
R-SCAN: Imaging for Pediatric Simple Febrile Seizures. ( 28551342 )
2017
21
Association of a novel GABRG2 splicing variation and a PTGS2/COX-2 single nucleotide polymorphism with Taiwanese febrile seizures. ( 27871023 )
2017
22
Novel Inflammatory Neuropathology in Immature Brain: (1) Fetal Tuberous Sclerosis, (2) Febrile Seizures, (3) I+-B-crystallin, and (4) Role of Astrocytes. ( 29103422 )
2017
23
The Effect of Quercetin on Pro- and Anti-Inflammatory Cytokines in a Prenatally Stressed Rat Model of Febrile Seizures. ( 28579828 )
2017
24
DPP4 regulates the inflammatory response in a rat model of febrile seizures. ( 28372289 )
2017
25
Febrile Seizures and Epilepsy: Association With Autism and Other Neurodevelopmental Disorders in the Child and Adolescent Twin Study in Sweden. ( 28754226 )
2017
26
Relationship between iron deficiency anemia and febrile seizures in children: A systematic review and meta-analysis. ( 28957722 )
2017
27
Frequency of acute bacterial meningitis in children with first episode of febrile seizures. ( 28770886 )
2017
28
Differences in Mean Platelet Volume and Platelet Count between Children with Simple and Complex Febrile Seizures. ( 28698727 )
2017
29
Identification of two mutations in cis in the SCN1A gene in a family showing genetic epilepsy with febrile seizures plus (GEFS+) and idiopathic generalized epilepsy (IGE). ( 28951233 )
2017
30
Long-term white matter tract reorganization following prolonged febrile seizures. ( 28332711 )
2017
31
The assessment of risk factors for febrile seizures in children. ( 28803641 )
2017
32
Evaluation of hippocampal infolding angle and incomplete hippocampal inversion in pediatric patients with epilepsy and febrile seizures. ( 28509667 )
2017
33
Vagus nerve stimulation for genetic epilepsy with febrile seizures plus (GEFS(+)) accompanying seizures with impaired consciousness. ( 28070485 )
2017
34
The semiology of febrile seizures: Focal features are frequent. ( 28622546 )
2017
35
Early-life febrile seizures worsen adult phenotypes in Scn1a mutants. ( 28373025 )
2017
36
Febrile seizures prior to sudden cardiac death: a Danish nationwide study. ( 29186479 )
2017
37
Analysis of plasma multiplex cytokines and increased level of IL-10 and IL-1Ra cytokines in febrile seizures. ( 29017522 )
2017
38
The assessment of laboratory parameters in children with fever and febrile seizures. ( 28729928 )
2017
39
Genetic epilepsy with febrile seizures plus: Refining the spectrum. ( 28842445 )
2017
40
Thiol/disulfide homeostasis as a novel indicator of oxidative stress in children with simple febrile seizures. ( 28808794 )
2017
41
EEG for children with complex febrile seizures. ( 28986982 )
2017
42
The Role of Human Coronaviruses in Children Hospitalized for Acute Bronchiolitis, Acute Gastroenteritis, and Febrile Seizures: A 2-Year Prospective Study. ( 27171141 )
2016
43
Urinary kidney injury molecules in children with febrile seizures. ( 27557879 )
2016
44
Role of multiplex PCR analysis in children with febrile seizures. ( 27324512 )
2016
45
Transient increase of interleukin-1I^ after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling. ( 26902320 )
2016
46
Prevalence of Febrile Seizures, Epilepsy, and Other Paroxysmal Attacks in a Swedish Cohort of 4-Year-Old Children. ( 27522228 )
2016
47
The Association Between Plasma Ferritin Level and Simple Febrile Seizures in Children. ( 27467370 )
2016
48
Neonatal hyperbilirubinemia and the risk of febrile seizures and childhood epilepsy. ( 27259071 )
2016
49
Distinguishing Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion from Prolonged Febrile Seizures by Acute Phase EEG Spectrum Analysis. ( 27046946 )
2016
50
Serum and CSF adiponectin, leptin, and interleukin 6 levels as adipocytokines in Egyptian children with febrile seizures: a cross-sectional study. ( 27068222 )
2016

Variations for Febrile Seizures

ClinVar genetic disease variations for Febrile Seizures:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SCN1A NM_001202435.2(SCN1A): c.327C> G (p.Tyr109Ter) single nucleotide variant Pathogenic GRCh37 Chromosome 2, 166915136: 166915136

Expression for Febrile Seizures

Search GEO for disease gene expression data for Febrile Seizures.

Pathways for Febrile Seizures

Pathways related to Febrile Seizures according to KEGG:

36
# Name Kegg Source Accession
1 Dopaminergic synapse hsa04728
2 Neuroactive ligand-receptor interaction hsa04080
3 GABAergic synapse hsa04727

Pathways related to Febrile Seizures according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.08 SCN1A SCN1B SCN9A
2
Show member pathways
11.53 SCN1A SCN1B SCN9A
3
Show member pathways
11.21 SCN1A SCN1B SCN9A
4 10.73 CHRNA4 GABRD GABRG2
5 10.55 GABRD GABRG2
6 10.28 SCN1A SCN1B SCN9A

GO Terms for Febrile Seizures

Cellular components related to Febrile Seizures according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.97 ADGRV1 CHRNA4 GABRD GABRG2 SCN1A SCN1B
2 plasma membrane GO:0005886 9.81 ADGRV1 CHRNA4 GABRD GABRG2 SCN1A SCN1B
3 neuronal cell body GO:0043025 9.71 CHRNA4 SCN1A SEZ6
4 synapse GO:0045202 9.71 ADGRV1 CHRNA4 GABRD GABRG2
5 axon GO:0030424 9.69 GABRG2 SCN1A STX1B
6 postsynaptic membrane GO:0045211 9.61 CHRNA4 GABRD GABRG2
7 chloride channel complex GO:0034707 9.49 GABRD GABRG2
8 intercalated disc GO:0014704 9.48 SCN1A SCN1B
9 T-tubule GO:0030315 9.46 SCN1A SCN1B
10 GABA-A receptor complex GO:1902711 9.37 GABRD GABRG2
11 node of Ranvier GO:0033268 9.26 SCN1A SCN1B
12 sodium channel complex GO:0034706 8.96 SCN1A SCN1B
13 voltage-gated sodium channel complex GO:0001518 8.8 SCN1A SCN1B SCN9A
14 membrane GO:0016020 10.18 ADGRV1 CHRNA4 GABRD GABRG2 SCN1A SCN1B

Biological processes related to Febrile Seizures according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 transport GO:0006810 9.8 CHRNA4 GABRD GABRG2 SCN1A SCN1B SCN9A
2 transmembrane transport GO:0055085 9.77 CHRNA4 GABRD GABRG2 SCN1A SCN9A
3 regulation of ion transmembrane transport GO:0034765 9.7 SCN1A SCN1B SCN9A
4 sodium ion transport GO:0006814 9.67 SCN1A SCN1B SCN9A
5 ion transport GO:0006811 9.63 CHRNA4 GABRD GABRG2 SCN1A SCN1B SCN9A
6 chemical synaptic transmission GO:0007268 9.62 CHRNA4 GABRD GABRG2 SCN1B
7 sodium ion transmembrane transport GO:0035725 9.61 SCN1A SCN1B SCN9A
8 sensory perception of pain GO:0019233 9.56 CHRNA4 SCN9A
9 neuronal action potential GO:0019228 9.55 SCN1A SCN9A
10 membrane depolarization during action potential GO:0086010 9.54 SCN1A SCN9A
11 membrane depolarization GO:0051899 9.51 CHRNA4 SCN1B
12 cardiac muscle cell action potential involved in contraction GO:0086002 9.48 SCN1A SCN1B
13 nervous system process GO:0050877 9.46 ADGRV1 CHRNA4
14 neuronal action potential propagation GO:0019227 9.4 SCN1A SCN1B
15 ion transmembrane transport GO:0034220 9.35 CHRNA4 GABRD GABRG2 SCN1A SCN9A
16 regulation of postsynaptic membrane potential GO:0060078 8.92 CHRNA4 SCN1A SCN1B SCN9A

Molecular functions related to Febrile Seizures according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.5 SCN1A SCN1B SCN9A
2 extracellular ligand-gated ion channel activity GO:0005230 9.43 CHRNA4 GABRD GABRG2
3 chloride channel activity GO:0005254 9.4 GABRD GABRG2
4 GABA-A receptor activity GO:0004890 9.37 GABRD GABRG2
5 sodium channel activity GO:0005272 9.33 SCN1A SCN1B SCN9A
6 voltage-gated sodium channel activity GO:0005248 9.13 SCN1A SCN1B SCN9A
7 ion channel activity GO:0005216 9.02 CHRNA4 GABRD GABRG2 SCN1A SCN9A

Sources for Febrile Seizures

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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