MCID: FBR031
MIFTS: 51

Febrile Seizures malady

Genetic diseases (common) category
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Summaries for Febrile Seizures

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44NINDS, 33MalaCards
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NINDS:44 Febrile seizures are convulsions brought on by a fever in infants or small children. During a febrile seizure, a child often loses consciousness and shakes.

MalaCards: Febrile Seizures, also known as febrile convulsions, is related to dravet syndrome and epilepsy syndrome. An important gene associated with Febrile Seizures is GABRG2 (gamma-aminobutyric acid (GABA) A receptor, gamma 2), and among its related pathways are Nicotine addiction and GABA signaling in brain. The drugs phenobarbital and phenobarbital sodium and the compounds (+)-bicuculline and (-)-bicuculline methochloride have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and cortex, and related mouse phenotypes are mortality/aging and behavior/neurological.

Aliases & Classifications for Febrile Seizures

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Sources:
44NINDS, 45Novoseek, 62UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

febrile seizures 44
febrile convulsions 62
seizures febrile 45


External Ids:

ICD1025 R56.0

Related Diseases for Febrile Seizures

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Familial Febrile Seizures 3b family:

febrile seizures Febrile Seizures, Familial, 3a
Febrile Seizures, Familial, 9 Febrile Seizures, Familial, 10
Febrile Seizures, Familial, 4 Febrile Seizures, Familial, 8
Febrile Seizures, Familial, 5 Febrile Seizures, Familial, 11
Febrile Seizures, Familial, 1 Febrile Seizures, Familial, 6
Febrile Seizures, Familial, 2 Febrile Seizures, Familial, 7

Diseases related to Febrile Seizures via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1dravet syndrome30.7GABRG2, GABRD, SCN1B, SCN1A
2epilepsy syndrome30.5SCN1A, SCN1B, GABRG2
3focal epilepsy30.3SCN1B
4idiopathic generalized epilepsy30.1SCN1A, GABRG2
5generalized epilepsy with febrile seizures plus10.9
6neuronitis10.6
7temporal lobe epilepsy10.6
8influenza10.6
9familial febrile seizures 3b10.5
10epilepsy, generalized, with febrile seizures plus, type 310.5
11epilepsy, generalized, with febrile seizures plus, type 110.5
12epilepsy, generalized, with febrile seizures plus, type 210.4
13meningitis10.4
14measles10.3
15mental retardation, keratoconus, febrile seizures, and sinoatrial block10.3
16epilepsy, generalized, with febrile seizures plus, type 510.3
17deficiency anemia10.3
18rubella10.3
19childhood absence epilepsy10.3
20iron deficiency anemia10.3
21mumps10.3
22encephalitis10.3
23scn1b-related generalized epilepsy with febrile seizures plus10.3
24gabrg2-related generalized epilepsy with febrile seizures plus10.3
25scn9a-related generalized epilepsy with febrile seizures plus10.3
26scn1a- related generalized epilepsy with febrile seizures plus10.3
27febrile seizures, familial, 1110.3
28attention deficit hyperactivity disorder10.2
29status epilepticus10.2
30pertussis10.2
31schizophrenia10.2
32gabrd-related generalized epilepsy with febrile seizures plus10.2
33scn1a-related simple febrile seizures10.2
34epilepsy, generalized, with febrile seizures plus, type 410.2
35febrile seizures, familial, 3a10.2
36epilepsy, generalized, with febrile seizures plus, type 710.2
37febrile seizures, familial, 910.2
38febrile seizures, familial, 1010.2
39febrile seizures, familial, 410.2
40febrile seizures, familial, 810.2
41epilespy, generalized, with febrile seizures plus, type 810.2
42febrile seizures, familial, 510.2
43epilepsy, generalized, with febrile seizures plus, type 610.2
44febrile seizures, familial, 110.2
45febrile seizures, familial, 610.2
46febrile seizures, familial, 210.2
47febrile seizures, familial, 710.2
48scn1a-related seizure disorders10.1SCN1A
49juvenile myoclonic epilepsy10.0GABRG2, SCN1A
50familial hemiplegic migraine10.0

Graphical network of the top 20 diseases related to Febrile Seizures:



Diseases related to febrile seizures

Symptoms for Febrile Seizures

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Drugs & Therapeutics for Febrile Seizures

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Febrile Seizures

Search NIH Clinical Center for Febrile Seizures

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Febrile Seizures

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Anatomical Context for Febrile Seizures

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33MalaCards
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MalaCards organs/tissues related to Febrile Seizures:

33
Temporal lobe, Brain, Cortex, Testes

Animal Models for Febrile Seizures or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Febrile Seizures:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.0GPR98, SCN1A, SCN1B, SCN9A, GABRD, GABRG2
2MP:00053867.9SCN1B, GPR98, SCN9A, GABRD, GABRG2, SCN1A
3MP:00036317.7GABRD, SCN9A, SCN1B, SCN1A, GABRG2, GPR98

Publications for Febrile Seizures

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Sources:
52PubMed
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Articles related to Febrile Seizures:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
SCN1A rs3812718 polymorphism and susceptibility to epilepsy with febrile seizures: a meta-analysis. (24076350)
2014
2
Broad Phenotypic Heterogeneity due to a Novel SCN1A Mutation in a Family With Genetic Epilepsy With Febrile Seizures Plus. (24257433)
2014
3
Prognostic factors for subsequent epilepsy in children with febrile seizures. (24304433)
2013
4
Measles-containing vaccines and febrile seizures in children age 4 to 6 years. (22473362)
2012
5
Febrile seizures after 2010-2011 influenza vaccine in young children, United States: a vaccine safety signal from the vaccine adverse event reporting system. (22361303)
2012
6
Inheritance of febrile seizures in sudden unexplained death in toddlers. (22490769)
2012
7
GABRG2 gene polymorphisms in Egyptian children with simple febrile seizures. (21983990)
2012
8
IL-1I^: an important cytokine associated with febrile seizures? (22622830)
2012
9
Neuronal injury and cytogenesis after simple febrile seizures in the hippocampal dentate gyrus of juvenile rat. (22661146)
2012
10
Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus. (21156207)
2011
11
Top 10 facts you need to know about febrile seizures. (22372159)
2011
12
Replication of association between a SCN1A splice variant and febrile seizures. (21762453)
2011
13
Epileptogenesis after prolonged febrile seizures: mechanisms, biomarkers and therapeutic opportunities. (21356275)
2011
14
Evaluation and management of pediatric febrile seizures in the emergency department. (21109105)
2011
15
Functional variant in complement C3 gene promoter and genetic susceptibility to temporal lobe epilepsy and febrile seizures. (20862287)
2010
16
Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures. (20587679)
2010
17
Novel human pathological mutations. Gene symbol: SCN1A. Disease: generalized epilepsy with febrile seizures plus. (21488303)
2010
18
Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. (20628201)
2010
19
Iron deficiency anaemia--a risk factor for febrile seizures in children. (22338422)
2010
20
The relationship between febrile seizures and epilepsy. (20331712)
2010
21
Altered EEG spectral activity and attentional behavioral deficits following prolonged febrile seizures: a pilot study. (19286493)
2009
22
Febrile seizures: mechanisms and relationship to epilepsy. (19232478)
2009
23
Does a SCN1A gene mutation confer earlier age of onset of febrile seizures in GEFS+? (19292758)
2009
24
Febrile seizures: interleukin 1beta and interleukin-1 receptor antagonist polymorphisms. (19135625)
2009
25
Current explanations regarding febrile seizures provided by pediatricians in Tokyo. (19459906)
2009
26
Phenomenology of prolonged febrile seizures: results of the FEBSTAT study. (18525033)
2008
27
Analysis of the GABRG2 gene mutation in a Chinese family with generalized epilepsy with febrile seizures plus]. (19065515)
2008
28
Gene symbol: SCN1A. Disease: Generalized epilepsy with febrile seizures plus. (18846618)
2008
29
Characterization of febrile seizures and febrile seizure susceptibility in mouse inbred strains. (18363854)
2008
30
Death in children with febrile seizures: a population-based cohort study. (18692714)
2008
31
Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function. (17629415)
2007
32
Molecular genetics of febrile seizures. (16887333)
2006
33
A novel GABRG2 mutation associated with febrile seizures. (16924025)
2006
34
Febrile seizure, but not hyperthermia alone, induces the expression of heme oxygenase-1 in rat cortex. (16537003)
2006
35
Genetic influence on the clinical characteristics and outcome of febrile seizures--a retrospective study. (15979359)
2005
36
Myoclonic seizures in the context of generalized epilepsy with febrile seizures plus (GEFS+). (15508917)
2005
37
Interleukin-1alpha, interleukin-1beta, and interleukin-1Ra polymorphisms in febrile seizures. (16159520)
2005
38
Febrile seizures. (16333484)
2005
39
Unconsciousness and delirious behavior in children with febrile seizures. (15165632)
2004
40
Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population. (15342122)
2004
41
Febrile seizures and mesial temporal sclerosis. (15021243)
2004
42
Interaction between endogenous nitric oxide and carbon monoxide in the pathogenesis of recurrent febrile seizures. (14766214)
2004
43
The genetics of febrile seizures and related epilepsy syndromes. (12850508)
2003
44
Interleukin-4 intron 3 polymorphism is not related to susceptibility to febrile seizures. (12435565)
2002
45
First place winner. Recurrent febrile seizures: an unusual presentation of nutritional rickets. (12480016)
2002
46
Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. (12040066)
2002
47
Intranasal midazolam effectively treats febrile seizures in children (10884278)
2000
48
Generalized epilepsy with febrile seizures plus: a common childhood-onset genetic epilepsy syndrome. (9894880)
1999
49
Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 in cerebrospinal fluid from children with prolonged febrile seizures. Comparison with acute encephalitis/encephalopathy. (9484363)
1998
50
Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes. (9126059)
1997

Variations for Febrile Seizures

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Expression for genes affiliated with Febrile Seizures

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Febrile Seizures

Search GEO for disease gene expression data for Febrile Seizures.

Pathways for genes affiliated with Febrile Seizures

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Sources:
50PathCards, 30KEGG, 12EMD Millipore, 54R&D Systems, 53QIAGEN, 55Reactome
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Compounds for genes affiliated with Febrile Seizures

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Sources:
61Tocris Bioscience, 45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB
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Compounds related to Febrile Seizures according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1(+)-bicuculline6110.1GABRD, GABRG2
2(-)-bicuculline methochloride6110.1GABRD, GABRG2
3(-)-bicuculline methiodide6110.1GABRD, GABRG2
4sr 95531 hydrobromide6110.1GABRD, GABRG2
5estazolam45 1111.1GABRD, GABRG2
6quazepam45 1111.1GABRG2, GABRD
7bromazepam45 1111.1GABRD, GABRG2
8lorazepam45 51 1112.1GABRG2, GABRD
9flurazepam45 1111.1GABRG2, GABRD
10oxazepam51 1111.1GABRD, GABRG2
11chlordiazepoxide45 1111.1GABRD, GABRG2
12clonazepam45 1111.0GABRD, GABRG2
13tbps45 2911.0GABRD, GABRG2
14muscimol45 61 2912.0GABRG2, GABRD
15triazolam45 1111.0GABRD, GABRG2
16alprazolam45 1111.0GABRG2, GABRD
17clobazam45 51 1111.9GABRG2, GABRD
18Gamma-Aminobutyric acid249.9GABRD, GABRG2
19midazolam45 51 1111.8GABRG2, GABRD
20diazepam45 29 51 1112.7GABRD, GABRG2
21nitrazepam45 1110.7SCN1A, GABRD, GABRG2
22bc-iii299.5SCN1A, SCN2A
23atx-ii299.5SCN1A, SCN2A
24aft-ii299.5SCN1A, SCN2A
25lamotrigine45 51 1111.5SCN2A, SCN1A
26topiramate45 51 24 1112.5SCN2A, SCN1A
27potassium45 24 1111.4GABRG2, SCN1B, SCN1A
28carbamazepine45 51 1111.1SCN2A, SCN1A
29saxitoxin299.1SCN2A, SCN9A, SCN1A
30batrachotoxin299.1SCN1A, SCN9A, SCN2A
31phenytoin45 51 29 1111.8SCN2A, SCN1A
32phrixotoxin 3618.8SCN2A, SCN1A, SCN1B, SCN9A
33qx 314 chloride618.7SCN1A, SCN1B, SCN9A, SCN2A
34tetrodotoxin citrate618.7SCN1A, SCN1B, SCN9A, SCN2A
35veratridine45 61 2910.7SCN1A, SCN1B, SCN9A, SCN2A
36zonisamide45 51 1110.7SCN1A, SCN1B, SCN9A, SCN2A
37tetrodotoxin45 61 2910.7SCN2A, SCN9A, SCN1B, SCN1A
38sodium45 249.4SCN1A, SCN1B, SCN9A, SCN2A, GABRG2

GO Terms for genes affiliated with Febrile Seizures

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16Gene Ontology
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Cellular components related to Febrile Seizures according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chloride channel complexGO:0347079.8GABRG2, GABRD
2node of RanvierGO:0332688.8SCN1A, SCN1B, SCN2A
3T-tubuleGO:0303158.7SCN1A, SCN1B, SCN2A
4intercalated discGO:0147048.5SCN1A, SCN1B, SCN2A
5voltage-gated sodium channel complexGO:0015188.4SCN2A, SCN9A, SCN1B, SCN1A

Biological processes related to Febrile Seizures according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1post-embryonic developmentGO:0097919.7GABRG2, SCN9A
2neuronal action potential propagationGO:0192279.6SCN1A, SCN1B
3neuronal action potentialGO:0192289.4SCN9A, SCN1A
4synaptic transmissionGO:0072689.1GABRG2, GABRD, SCN1B
5sodium ion transportGO:0068148.7SCN2A, SCN9A, SCN1A
6sodium ion transmembrane transportGO:0357258.4SCN2A, SCN9A, SCN1B, SCN1A

Molecular functions related to Febrile Seizures according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chloride channel activityGO:0052549.8GABRG2, GABRD
2GABA-A receptor activityGO:0048909.7GABRD, GABRG2
3extracellular ligand-gated ion channel activityGO:0052309.5GABRG2, GABRD
4voltage-gated sodium channel activityGO:0052488.3SCN2A, SCN9A, SCN1B, SCN1A

Products for genes affiliated with Febrile Seizures

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Sources for Febrile Seizures

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet