MCID: FBR031
MIFTS: 35

Febrile Seizures malady

Summaries for Febrile Seizures

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43NINDS, 32MalaCards
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NINDS:43 Febrile seizures are convulsions brought on by a fever in infants or small children. During a febrile seizure, a child often loses consciousness and shakes.

MalaCards: Febrile Seizures, also known as febrile convulsions, is related to generalized epilepsy with febrile seizures plus and epilepsy syndrome. An important gene associated with Febrile Seizures is GABRG2 (gamma-aminobutyric acid (GABA) A receptor, gamma 2), and among its related pathways are Circadian entrainment and Synaptic transmission: ion currents. The drugs phenobarbital and phenobarbital sodium and the compounds Cinolazepam and Halazepam have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Febrile Seizures

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43NINDS, 44Novoseek, 60UMLS, 25ICD10
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Classifications:



Aliases & Descriptions:

febrile seizures 43
febrile convulsions 60
seizures febrile 44


External Ids:

ICD1025 R56.0

Related Diseases for Febrile Seizures

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Familial Febrile Seizures 3b family:

febrile seizures Febrile Seizures, Familial, 3a
Febrile Seizures, Familial, 9 Febrile Seizures, Familial, 10
Febrile Seizures, Familial, 4 Febrile Seizures, Familial, 8
Febrile Seizures, Familial, 5 Febrile Seizures, Familial, 11
Febrile Seizures, Familial, 1 Febrile Seizures, Familial, 6
Febrile Seizures, Familial, 2 Febrile Seizures, Familial, 7

Diseases related to Febrile Seizures via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1generalized epilepsy with febrile seizures plus31.3SCN1B
2epilepsy syndrome30.8KCNQ2, SCN1B, GABRG2, SCN1A
3dravet syndrome30.6SCN1A, SCN8A, GABRD, SCN1B, GABRG2
4focal epilepsy30.2GABRG2, SCN1A
5idiopathic generalized epilepsy30.0SCN1A, KCNQ2, GABRG2
6brugada syndrome30.0SCN8A, SCN1B
7neuronitis10.6
8temporal lobe epilepsy10.6
9influenza10.5
10familial febrile seizures 3b10.5
11epilepsy, generalized, with febrile seizures plus, type 110.5
12epilepsy, generalized, with febrile seizures plus, type 310.4
13epilepsy, generalized, with febrile seizures plus, type 210.4
14meningitis10.3
15measles10.3
16epilepsy, generalized, with febrile seizures plus, type 510.3
17deficiency anemia10.2
18rubella10.2
19childhood absence epilepsy10.2
20iron deficiency anemia10.2
21mumps10.2
22encephalitis10.2
23mental retardation, keratoconus, febrile seizures, and sinoatrial block10.2
24scn1b-related generalized epilepsy with febrile seizures plus10.2
25gabrg2-related generalized epilepsy with febrile seizures plus10.2
26scn9a-related generalized epilepsy with febrile seizures plus10.2
27scn1a- related generalized epilepsy with febrile seizures plus10.2
28febrile seizures, familial, 1110.2
29attention deficit hyperactivity disorder10.1
30status epilepticus10.1
31bacterial meningitis10.1
32pertussis10.1
33schizophrenia10.1
34gabrd-related generalized epilepsy with febrile seizures plus10.1
35scn1a-related simple febrile seizures10.1
36epilepsy, generalized, with febrile seizures plus, type 410.1
37febrile seizures, familial, 3a10.1
38epilepsy, generalized, with febrile seizures plus, type 710.1
39febrile seizures, familial, 910.1
40febrile seizures, familial, 1010.1
41febrile seizures, familial, 410.1
42febrile seizures, familial, 810.1
43epilespy, generalized, with febrile seizures plus, type 810.1
44febrile seizures, familial, 510.1
45epilepsy, generalized, with febrile seizures plus, type 610.1
46febrile seizures, familial, 110.1
47febrile seizures, familial, 610.1
48febrile seizures, familial, 210.1
49febrile seizures, familial, 710.1
50exanthema subitum10.1

Graphical network of the top 20 diseases related to Febrile Seizures:



Diseases related to febrile seizures

Clinical Features for Febrile Seizures

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Drugs & Therapeutics for Febrile Seizures

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Febrile Seizures

Drug clinical trials:

Search ClinicalTrials for Febrile Seizures

Search NIH Clinical Center for Febrile Seizures

Search CenterWatch for Febrile Seizures

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Febrile Seizures

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Anatomical Context for Febrile Seizures

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Animal Models for Febrile Seizures or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Febrile Seizures:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.1ICAM5, SCN1B, SCN8A, SCN9A, SCN1A, GABRD
2MP:00053869.8GPR98, KCNQ2, ICAM5, SCN1B, SCN8A, SCN9A

Publications for Febrile Seizures

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Genetic Variations for Febrile Seizures

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Expression for genes affiliated with Febrile Seizures

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Febrile Seizures

Search GEO for disease gene expression data for Febrile Seizures.

Pathways for genes affiliated with Febrile Seizures

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Sources:
29KEGG, 12EMD Millipore, 51QIAGEN, 53Reactome
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Compounds for genes affiliated with Febrile Seizures

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Sources:
11DrugBank, 44Novoseek, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Febrile Seizures according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1Cinolazepam1110.8GABRG2, GABRD
2Halazepam1110.8GABRG2, GABRD
3lamotrigine44 1111.8SCN1A, SCN2A
4Fludiazepam1110.8GABRG2, GABRD
5(+)-bicuculline5910.8GABRD, GABRG2
6(-)-bicuculline methochloride5910.7GABRD, GABRG2
7nitrazepam44 1111.7GABRG2, GABRD, SCN1A
8(-)-bicuculline methiodide5910.7GABRD, GABRG2
9aft-ii2810.7SCN2A, SCN8A, SCN1A
10bc-iii2810.7SCN2A, SCN8A, SCN1A
11sr 95531 hydrobromide5910.7GABRD, GABRG2
12atx-ii2810.7SCN2A, SCN8A, SCN1A
13Prazepam1110.7GABRD, GABRG2
14estazolam44 1111.7GABRG2, GABRD
15saxitoxin2810.7SCN1A, SCN9A, SCN8A, SCN2A
16batrachotoxin2810.7SCN2A, SCN8A, SCN9A, SCN1A
17Adinazolam1110.7GABRG2, GABRD
18quazepam44 1111.7GABRG2, GABRD
19zonisamide44 1111.7SCN2A, SCN1B, SCN9A, SCN1A
20phrixotoxin 35910.7SCN1A, SCN2A, SCN1B, SCN8A, SCN9A
21Clotiazepam1110.7GABRD, GABRG2
22qx 314 chloride5910.7SCN2A, SCN1B, SCN8A, SCN9A, SCN1A
23tetrodotoxin citrate5910.7SCN2A, SCN1B, SCN8A, SCN9A, SCN1A
24veratridine44 59 2812.7SCN2A, SCN1B, SCN8A, SCN9A, SCN1A
25Clorazepate1110.7GABRG2, GABRD
26tetrodotoxin44 59 2812.7SCN2A, SCN1B, SCN8A, SCN9A, SCN1A
27bromazepam44 1111.7GABRG2, GABRD
28Temazepam1110.6GABRD, GABRG2
29potassium44 11 2412.6KCNQ2, SCN1B, SCN8A, SCN1A, GABRG2
30lorazepam44 49 1112.6GABRD, GABRG2
31flurazepam44 1111.6GABRD, GABRG2
32oxazepam49 1111.6GABRD, GABRG2
33clobazam44 49 1112.6GABRD, GABRG2
34sodium44 2411.5KCNQ2, SCN2A, SCN7A, SCN1B, SCN8A, SCN9A
35chlordiazepoxide44 1111.5GABRD, GABRG2
36tbps44 2811.5GABRD, GABRG2
37clonazepam44 1111.4GABRD, GABRG2
38alprazolam44 1111.4GABRG2, GABRD
39muscimol44 59 2812.3GABRG2, GABRD
40triazolam44 1111.1GABRG2, GABRD

GO Terms for genes affiliated with Febrile Seizures

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16Gene Ontology
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Cellular components related to Febrile Seizures according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intercalated discGO:01470410.4SCN1A, SCN1B, SCN2A
2voltage-gated sodium channel complexGO:00151810.3SCN1A, SCN9A, SCN8A, SCN1B, SCN7A, SCN2A
3node of RanvierGO:03326810.3KCNQ2, SCN2A, SCN1B, SCN8A, SCN1A
4axon initial segmentGO:04319410.2SCN1A, SCN8A, KCNQ2
5T-tubuleGO:03031510.1SCN2A, SCN1B, SCN1A

Biological processes related to Febrile Seizures according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal action potential propagationGO:01922710.5SCN1A, SCN1B
2regulation of action potential in neuronGO:01922810.4SCN9A, SCN1A
3myelinationGO:04255210.4SCN8A, SCN2A
4sodium ion transportGO:00681410.4SCN1A, SCN9A, SCN8A, SCN7A, SCN2A
5synaptic transmissionGO:00726810.2GABRG2, GABRD, SCN1B, KCNQ2
6adult walking behaviorGO:00762810.1SCN1A, SCN8A

Molecular functions related to Febrile Seizures according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular ligand-gated ion channel activityGO:00523010.4GABRG2, GABRD
2GABA-A receptor activityGO:00489010.1GABRG2, GABRD
3voltage-gated sodium channel activityGO:00524810.1SCN1A, SCN2A, SCN7A, SCN1B, SCN8A, SCN9A

Products for genes affiliated with Febrile Seizures

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  • Antibodies
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  • Antibodies

Sources for Febrile Seizures

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet