Aliases & Classifications for Fecal Incontinence

MalaCards integrated aliases for Fecal Incontinence:

Name: Fecal Incontinence 38 69

Summaries for Fecal Incontinence

MalaCards based summary : Fecal Incontinence is related to meningovascular neurosyphilis and lymphocytic colitis, and has symptoms including abdominal pain, cachexia and constipation. The drugs Glycerol and Loperamide have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Adipose.

Wikipedia : 72 Fecal incontinence (FI), also known as anal incontinence, or in some forms encopresis, is a lack of... more...

Related Diseases for Fecal Incontinence

Diseases related to Fecal Incontinence via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
id Related Disease Score Top Affiliating Genes
1 meningovascular neurosyphilis 10.9
2 lymphocytic colitis 10.9
3 steatorrhea 10.9
4 pudendal neuralgia 10.9
5 constipation 10.5
6 rectal prolapse 10.3
7 obesity 10.1
8 vaginitis 10.1
9 imperforate anus 10.1
10 prostate cancer 10.1
11 prostatitis 10.1
12 inflammatory bowel disease 10.0
13 neuropathy 10.0
14 irritable bowel syndrome 10.0
15 dermatitis 10.0
16 dementia 9.9
17 crohn's disease 9.9
18 morbid obesity 9.7
19 cerebritis 9.7
20 kidney disease 9.7
21 neuronitis 9.7
22 myelomeningocele 9.7
23 autonomic neuropathy 9.7
24 gastroparesis 9.7
25 colorectal cancer 9.7
26 diarrhea 9.7
27 attention deficit-hyperactivity disorder 9.7
28 celiac disease 9.7
29 complex regional pain syndrome 9.7

Comorbidity relations with Fecal Incontinence via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Heart Disease Hypertension, Essential
Parkinson Disease, Late-Onset Protein-Energy Malnutrition
Rectal Prolapse Schizophreniform Disorder

Graphical network of the top 20 diseases related to Fecal Incontinence:



Diseases related to Fecal Incontinence

Symptoms & Phenotypes for Fecal Incontinence

UMLS symptoms related to Fecal Incontinence:


abdominal pain, cachexia, constipation, cyanosis, diarrhea, dyspepsia, dyspnea, edema, fever, flatulence, eructation, and gas pain, headache, heartburn, icterus, nausea and vomiting, seizures, signs and symptoms, signs and symptoms, digestive, syncope, vertigo, symptoms involving digestive system, other symptoms involving digestive system, rectal tenesmus, bowel urgency, gastrointestinal gas, hot flushes, colonic inertia, disturbance in bowel function, symptoms, full incontinence of feces

Drugs & Therapeutics for Fecal Incontinence

Drugs for Fecal Incontinence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 196)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycerol Approved, Investigational Phase 4,Phase 3 56-81-5 753
2
Loperamide Approved Phase 4,Phase 2,Phase 3 53179-11-6 3955
3
Lubiprostone Approved, Investigational Phase 4 136790-76-6 656719
4 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
5 Antidiarrheals Phase 4,Phase 2,Phase 3
6 Calcium polycarbophil Phase 4,Phase 2,Phase 3
7 Calcium, Dietary Phase 4,Phase 2,Phase 3
8 Cathartics Phase 4,Phase 2,Phase 3
9 Laxatives Phase 4,Phase 2,Phase 3
10 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
11 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2
12 Acidophilus Nutraceutical Phase 4,Phase 2
13 Cola Nutraceutical Phase 4
14 Psyllium Nutraceutical Phase 4,Phase 2,Phase 3
15
Menthol Approved Phase 3,Phase 1 2216-51-5 16666
16
Lactulose Approved Phase 3 4618-18-2 11333
17
Metronidazole Approved Phase 3 443-48-1 4173
18
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
19
Gemcitabine Approved Phase 3 95058-81-4 60750
20
Pemetrexed Approved, Investigational Phase 3 150399-23-8, 137281-23-3 446556 60843
21
Clonidine Approved Phase 3,Phase 2 4205-90-7 2803
22
Bisacodyl Approved Phase 3,Phase 2 603-50-9
23
Ephedrine Approved Phase 3,Phase 1,Phase 2 299-42-3 9294
24
Oxymetazoline Approved Phase 3,Phase 1,Phase 2 1491-59-4 4636
25
Phenylephrine Approved Phase 3,Phase 1,Phase 2 59-42-7 6041
26
Pseudoephedrine Approved Phase 3,Phase 1,Phase 2 90-82-4 7028
27
Acetylcholine Approved Phase 3,Phase 2 51-84-3 187
28
Cyproterone Acetate Approved, Investigational Phase 3 427-51-0
29
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
30
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
31
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
32
Docetaxel Approved May 1996, Investigational Phase 3 114977-28-5 148124 9877265
33 Coagulants Phase 3,Phase 1
34 Fibrin Tissue Adhesive Phase 3,Phase 1
35 Hemostatics Phase 3,Phase 1
36 abobotulinumtoxinA Phase 3,Phase 2
37 Botulinum Toxins, Type A Phase 3,Phase 2
38 Neurotransmitter Agents Phase 3,Phase 2,Phase 1
39 onabotulinumtoxinA Phase 3,Phase 2
40 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
41 Autonomic Agents Phase 3,Phase 2,Phase 1
42 Antineoplastic Agents, Hormonal Phase 3
43 Hormone Antagonists Phase 3
44 Hormones Phase 3
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
46 Anesthetics Phase 3,Phase 1,Phase 2
47 Respiratory System Agents Phase 3,Phase 1,Phase 2
48 Anti-Infective Agents Phase 3
49 Antiparasitic Agents Phase 3
50 Antiprotozoal Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 284)

id Name Status NCT ID Phase Drugs
1 Lactobacillus Reuteri in Children With Constipation Unknown status NCT01388712 Phase 4
2 Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury Completed NCT00286520 Phase 4
3 Sacral Nerve Stimulation for Anal Incontinence and Bowel Control Completed NCT00200005 Phase 4
4 Polyacrylamide Hydrogel Injection Treatment for Anal Incontinence Completed NCT02550899 Phase 4
5 A Modified Surgical Approach to Women With Obstetric Anal Sphincter Tears Completed NCT01021722 Phase 4
6 Short Protocol Barostat for Assessment of Anorectal Function Versus Standard Protocol Barostat in Healthy Volunteers Completed NCT01456442 Phase 4
7 Psyllium Fiber Versus Placebo in Early Treatment After STARR for Obstructed Defecation: a Double-blind RCT Completed NCT02136693 Phase 4 Psyllium fiber;Placebo
8 Safety and Efficacy of Lubiprostone in Pediatric Patients With Constipation Completed NCT00452335 Phase 4 Lubiprostone;Lubiprostone;Lubiprostone
9 A Study to Compare the Effect of Transipeg 2.95 g or Forlax Junior 4 g in Children With Constipation Completed NCT01810653 Phase 4 Macrogol (Transipeg, BAY81-8430);Macrogol (Forlax)
10 A Within Subjects Comparison of Two Antegrade Flushing Regimens in Children Recruiting NCT02435069 Phase 4 NS and USP Glycerin - Dose Response;NS and USP Glycerin - Effectiveness
11 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Recruiting NCT02216305 Phase 4
12 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Recruiting NCT01312259 Phase 4
13 Comparison of Esophageal and Anorectal Manometry Catheters Terminated NCT00204763 Phase 4
14 Imodium Syrup Versus Imodium Tablets for Faecal Incontinence Withdrawn NCT00933465 Phase 4 Imodium (Loperamide Hydrochloride) syrup;Imodium (Loperamide hydrochloride) tablets
15 Therapeutic Management of Complex Anal Fistulas by Installing a Closure Clip: Multicentre Randomized Controlled Trial Unknown status NCT02336867 Phase 2, Phase 3
16 Ligation of Intersphincteric Fistula Tract (LIFT) Versus LIFT-plug Procedure for Anal Fistula Repair Unknown status NCT01478139 Phase 3
17 Efficacy and Mechanisms of Pharmacologic Treatment of Fecal Incontinence Completed NCT00727649 Phase 2, Phase 3 Psyllium powder;Loperamide
18 Percutaneous Tibial Nerve Stimulation in the Treatment of Fecal Incontinence Completed NCT00974909 Phase 3
19 UK Trial of Percutaneous Tibial Nerve Stimulation in Patients With Faecal Incontinence Completed NCT02349334 Phase 3
20 Autologous Myoblast Intrasphincteric Injection for Fecal Incontinence Completed NCT01523522 Phase 2, Phase 3
21 Controlling Anal Incontinence by Performing Anal Exercises With Biofeedback or Loperamide (CAPABLe) Completed NCT02008565 Phase 3 Loperamide;Placebo
22 Triple Target Treatment (3T) Which Combines Stimulation With Amplitude Modulated Middle Frequency (AM-MF), Electromyography (EMG)-Triggered Stimulation and EMG-Biofeedback Compared With EMG-Biofeedback in Anal Incontinence Completed NCT00525291 Phase 3
23 Behavioral Therapy Of Obstetric Sphincter Tears Completed NCT01166399 Phase 3
24 To Determine the Effect of Forlax® Treatment in Children With Chronic Constipation Who May Also Suffer From Soiling/ Faecal Incontinence. Completed NCT00255372 Phase 3 PEG 4000 (Forlax®);Lactulose active and Lactulose placebo
25 Does the Negativation of the Glucose Hydrogen Breath Test Come Along With a Reduction of the Symptoms of Gaz Incontinence ? Completed NCT01275560 Phase 3 Metronidazole;CArbosylane
26 Prenatal Pelvic Floor Prevention (3PN) Completed NCT00551551 Phase 3
27 Sacral Neuromodulation (SNM) With InterStimTM for Bowel Dysfunction Following Surgery for Rectal Cancers With Sphincter Preservation Completed NCT02163187 Phase 2, Phase 3
28 Trial Involving Subjects Over 70 Years of Age With Non Small-cell Lung Cancer of Stage IV and Comparing a "Classical" Strategy of Treatment Allocation, With an"Optimized" Strategy Allocating the Same Treatments Completed NCT01257139 Phase 3
29 Efficacy and Safety of Adipose Stem Cells to Treat Complex Perianal Fistulas Not Associated to Crohn´s Disease Completed NCT00475410 Phase 3 ASCs (Cx401, company code);Fibrin adhesive
30 Prucalopride in Pediatric Subjects With Functional Constipation Completed NCT01330381 Phase 3 prucalopride;Placebo;PEG 4000
31 Pelvic Floor Muscle Training and Biofeedback or Standard Therapy in Men Who Have Undergone Radical Prostatectomy or Transurethral Resection of the Prostate Completed NCT00632138 Phase 3
32 Study to Examine the Efficacy and Safety of Movicol in the Treatment of Chronic Constipation in Children Completed NCT00403819 Phase 3 Polyethylene glycol 3350 Na bicarbonate NaCl KCl (Movicol)
33 An Open Single Centre Study To Assess Treatment of Chronic Constipation in Children Completed NCT00403897 Phase 3 Polyethylene glycol 3350 Na bicarbonate NaCl KCl
34 Effect and Tolerance of Botulinum A Toxin Rectal Injections on Fecal Incontinence Recruiting NCT02414425 Phase 3 Botulinum toxin A or physiologic serum injection
35 A Study of Colesevelam in Fecal Incontinence Recruiting NCT02628626 Phase 3 Colesevelam;Clonidine
36 MEdical Versus SUrgical Treatments of Rectal Endometriosis Recruiting NCT01973816 Phase 3 Triptoreline 11.25 i.v.; Estradiol 0.5% percutaneous gel;;Cyproterone acetate 50 mg; estradiol 0.5% percutaneous;Estradiol 0.5% percutaneous gel; Cyproterone acetate 50 mg oral
37 Bulking Agent Versus Electrostimulation Therapy in Anal Incontinence Not yet recruiting NCT03052946 Phase 2, Phase 3
38 Feasibility Study to Assess the Early Use of Porcine Cross-linked Collagen Paste in Cryptoglandular Anorectal Fistulas Not yet recruiting NCT02686580 Phase 3
39 Encopresis & MIE (DoD #2) Not yet recruiting NCT03197922 Phase 3
40 Gore-BioA Fistula Plug to Treat Transsphincteric Fistulas Terminated NCT01584752 Phase 3
41 Seton or Glue for Trans-sphincteric Anal Fistulas Terminated NCT00929630 Phase 3
42 Comparison of PTNS and Biofeedback for Fecal Incontinence Withdrawn NCT01882101 Phase 3
43 A Study to Evaluate Topical Phenylephrine Gel in the Management of Faecal Incontinence Withdrawn NCT00420797 Phase 3 10% Phenylephrine hydrochloride gel
44 Pilot Study of NASHA/Dx Gel for Fecal Incontinence Unknown status NCT00971269 Phase 1, Phase 2
45 Stem Cells Therapy for Fecal Incontinence in Children After Posterior Sagittal Ano-rectoplasty Unknown status NCT02161003 Phase 1, Phase 2
46 Percutaneous Tibial Nerve Stimulation in the Treatment of Anterior Resection Syndrome After Rectal Cancer Surgery Unknown status NCT02177084 Phase 2
47 Percutaneous Tibial Nerve Stimulation for the Treatment of Fecal Incontinence Completed NCT00977652 Phase 2
48 A Placebo-Controlled Study of Clonidine for Fecal Incontinence. Completed NCT00884832 Phase 2 Clonidine;Placebo
49 Evaluation of Outcomes of Restoring Pelvic Floor Support With TOPAS in Women With Moderate Fecal Incontinence Symptoms Completed NCT00565136 Phase 1, Phase 2
50 A Multi-centre, Phase II, Double-blind, Randomised, Placebo-controlled, Parallel Group, Dose-ranging Study in Patients With Faecal Incontinence; to Evaluate the Efficacy, Safety and Tolerability of Locally Applied NRL001 Over an 8 Week Treatment Period Completed NCT01656720 Phase 2 1R, 2S-methoxamine hydrochloride;Placebo

Search NIH Clinical Center for Fecal Incontinence

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Fecal Incontinence cell therapies at LifeMap Discovery.

Genetic Tests for Fecal Incontinence

Anatomical Context for Fecal Incontinence

MalaCards organs/tissues related to Fecal Incontinence:

39
Colon, Spinal Cord, Testes, Bone, Prostate, Lung, Bone Marrow
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Fecal Incontinence:
id Tissue Anatomical CompartmentCell Relevance
1 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Fecal Incontinence

Articles related to Fecal Incontinence:

(show top 50) (show all 618)
id Title Authors Year
1
Sacral nerve stimulation for constipation and fecal incontinence in children: Long-term outcomes, patient benefit, and parent satisfaction. ( 28799195 )
2017
2
What Works to Improve and Manage Fecal Incontinence in Care Home Residents Living With Dementia? A Realist Synthesis of the Evidence. ( 28859818 )
2017
3
Temperature-Controlled Delivery of Radiofrequency Energy in Fecal Incontinence: A Randomized Sham-Controlled Clinical Trial. ( 28682972 )
2017
4
Novel insights into fecal incontinence in men. ( 27881404 )
2017
5
Metabolites and microbial composition of stool of women with fecal incontinence: Study design and methods. ( 28763566 )
2017
6
Fecal incontinence in patients with spina bifida: The target is the rectum. ( 28950040 )
2017
7
Surgical Interventions and the Use of Device-Aided Therapy for the Treatment of Fecal Incontinence and Defecatory Disorders. ( 28838787 )
2017
8
The anal canal is the fine line between "fecal incontinence and colitis" after a pull-through for Hirschsprung disease. ( 28941931 )
2017
9
Validation of Risk Factors for Fecal Incontinence in Patients With Crohn's Disease. ( 28682970 )
2017
10
Analysis of Factors Associated with Patient or Caregiver Regret following Surgery for Fecal Incontinence. ( 28728991 )
2017
11
The relationship between fecal incontinence and vaginal delivery in the postmenopausal stage. ( 28913133 )
2017
12
Sacral Neuromodulation for Fecal Incontinence: A Review of the Central Mechanisms of Action. ( 28723864 )
2017
13
Neurostimulation for fecal incontinence after correction of repair of imperforate anus. ( 28352637 )
2017
14
Continuing Medical Education: September 2017: Fecal Incontinence Is Associated With Mortality Among Older Adults With Complex Needs: An Observational Cohort Study. ( 28874858 )
2017
15
Continuing Medical Education Questions: September 2017: Fecal Incontinence Is Associated With Mortality Among Older Adults With Complex Needs: An Observational Cohort Study. ( 28874872 )
2017
16
Fecal Incontinence Is Associated With Mortality Among Older Adults With Complex Needs: An Observational Cohort Study. ( 28762377 )
2017
17
Examining Sensory Overresponsiveness in Preschool Children With Retentive Fecal Incontinence. ( 28809659 )
2017
18
Contemporary short- and long-term outcomes in patients with unremitting constipation and fecal incontinence treated with an antegrade continence enema. ( 27817835 )
2017
19
Rationale for Investigating Stool Metabolites and Microbiota in Women With Fecal Incontinence. ( 28059923 )
2017
20
Management of Fecal Incontinence in Older People With Dementia Resident in Care Homes: A Realist Synthesis-The FINCH Study. ( 28739491 )
2017
21
Physical Therapy for Fecal Incontinence in Children with Pelvic Floor Dyssynergia. ( 28807359 )
2017
22
Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence. ( 28730720 )
2017
23
Long-term Experience of Magnetic Anal Sphincter Augmentation in Patients With Fecal Incontinence. ( 27926562 )
2017
24
Clinical anatomy of fecal incontinence in women. ( 28699286 )
2017
25
Prospective cohort study of phenotypic variation based on an anal sphincter function in adults with fecal incontinence. ( 27144375 )
2016
26
Sacral nerve stimulation for fecal incontinence in a patient with anti-phospholipid syndrome-related autonomic neuropathy. ( 26670782 )
2016
27
Pathophysiology of fecal incontinence differs between men and women: a case-matched study in 200 patients. ( 27206812 )
2016
28
Validation of the Fecal Incontinence Severity Index in a Turkish Population. ( 26945267 )
2016
29
How to Size the Anal Canal Circumference When Implanting a Magnetic Anal Sphincter for Fecal Incontinence. Evolution and Update of a New Surgical Technique. ( 27505121 )
2016
30
Characteristics Associated With Successful Fitting of a Vaginal Bowel Control System for Fecal Incontinence. ( 27564386 )
2016
31
Efficacy of Biofeedback Therapy before and after Sphincteroplasty for Fecal Incontinence because of Obstetric Injury: A Randomized Controlled Trial. ( 26989283 )
2016
32
The fecal incontinence quality of life scale (FIQL) and fecal incontinence severity index (FISI): Validation of the Dutch versions. ( 27028557 )
2016
33
Fecal incontinence in irritable bowel syndrome: Prevalence and associated factors in Swedish and American patients. ( 27581702 )
2016
34
Characteristics of the Contrast Enema Do Not Predict an Effective Bowel Management Regimen for Patients with Constipation or Fecal Incontinence. ( 27688984 )
2016
35
Re: Prevalence of Fecal Incontinence (FI) and Associated Factors in Institutionalized Older Adults. ( 27628815 )
2016
36
Incontinence-Associated Dermatitis in Nursing Homes: Prevalence, Severity, and Risk Factors in Residents With Urinary and/or Fecal Incontinence. ( 27749788 )
2016
37
Safety and Efficacy of Permacol Injection in the Treatment of Fecal Incontinence. ( 27218098 )
2016
38
Sacral nerve stimulation versus percutaneous posterior tibial nerve stimulation in the treatment of severe fecal incontinence in men. ( 26925981 )
2016
39
Effect of age, patient's sex, and type of trauma on the correlation between size of sphincter defect and anal pressures in posttraumatic fecal incontinence. ( 27392390 )
2016
40
Treating Fecal Incontinence: An Unmet Need in Primary Care Medicine. ( 27154893 )
2016
41
Current Trends in Management of Defecatory Dysfunction, Posterior Compartment Prolapse, and Fecal Incontinence. ( 27547494 )
2016
42
Validating endpoints for therapeutic trials in fecal incontinence. ( 26948292 )
2016
43
Evidence-Based Update on Treatments of Fecal Incontinence in Women. ( 26880511 )
2016
44
Adverse events of sacral neuromodulation for fecal incontinence reported to the federal drug administration. ( 27158546 )
2016
45
Role of diet in fecal incontinence: a systematic review of the literature. ( 26883367 )
2016
46
Health Related Quality of Life and Parental Stress in Children with Fecal Incontinence: A Normative Comparison. ( 27027905 )
2016
47
Prevalence of Fecal Incontinence in the Acute Care Setting. ( 27607748 )
2016
48
On the prevalence of constipation and fecal incontinence, and their co-occurrence, in the Netherlands. ( 27913883 )
2016
49
Role of Permacol Injection in the Treatment of Patients With Fecal Incontinence. ( 27218094 )
2016
50
A Content Incontinent: Report of Liposomal Bupivacaine Induced Fecal Incontinence. ( 27747127 )
2016

Variations for Fecal Incontinence

Expression for Fecal Incontinence

Search GEO for disease gene expression data for Fecal Incontinence.

Pathways for Fecal Incontinence

GO Terms for Fecal Incontinence

Sources for Fecal Incontinence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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