FS
MCID: FNG005
MIFTS: 40

Feingold Syndrome (FS) malady

Bone diseases, Fetal diseases categories

Summaries for Feingold Syndrome

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21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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Genetics Home Reference:21 Feingold syndrome is a disorder that affects many parts of the body. The signs and symptoms of this condition vary among affected individuals, even among members of the same family.

MalaCards: Feingold Syndrome, also known as brunner-winter syndrome, is related to rhabdomyosarcoma and feingold syndrome 1, and has symptoms including cleft lip and palate, sensorineural deafness/hearing loss and abnormal vertebral size/shape. An important gene associated with Feingold Syndrome is MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog). Affiliated tissues include pancreas, spleen and bone.

Wikipedia:63 Feingold syndrome (also called oculodigitoesophagoduodenal syndrome) is a rare autosomal dominant... more...

Description from OMIM:46 164280,614326

Aliases & Classifications for Feingold Syndrome

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Sources:
42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 46OMIM, 48Orphanet, 60UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

48
feingold syndrome:
Inheritance: Autosomal dominant; Prevalence: <1/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

feingold syndrome 42 22 21 46 48 60
brunner-winter syndrome 42 48
digital anomalies with short palpebral fissures and atresia of esophagus or duodenum type 1 48
digital anomalies with short palpebral fissures and atresia of esophagus, or duodenum 42
digital anomalies with short palpebral fissures and atresia of esophagus or duodenum 48
microcephaly - intellectual deficit - tracheoesophageal fistula type 1 48
microcephaly-mesobrachyphalangy-tracheoesophageal fistula syndrome 21
microcephaly - intellectual deficit - tracheoesophageal fistula 48
microcephaly - oculo-digito-esophageal-duodenal syndrome type 1 48
microcephaly-digital anomalies-normal intelligence syndrome 48
microcephaly-digital anomalies-normal intelligence type 1 48
microcephaly-oculo-digito-esophageal-duodenal syndrome 21
microcephaly - oculo-digito-esophageal-duodenal syndrome 48
microcephaly-oculo-digito-esophageal-duodenal syndrome 42
oculo-digito-esophageal-duodenal syndrome type 1 48
oculo-digito-esophagoduodental syndrome 21
oculo-digito-esophageal-duodenal syndrome 48
oculodigitoesophagoduodenal syndrome 42
brunner-winter syndrome type 1 48
feingold syndrome type 1 48
moded syndrome type 1 48
oded syndrome type 1 48
moded syndrome 48
oded syndrome 48
mmt syndrome 42
mmt type 1 48
fglds1 48
fglds 48
fs1 48
mmt 48
fs 48


External Ids:

ICD10 via Orphanet26 Q87.8

Related Diseases for Feingold Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Feingold Syndrome:



Diseases related to feingold syndrome

Clinical Features for Feingold Syndrome

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

164280,614326

Clinical synopsis from OMIM:

164280

Symptoms:

48 (show all 23)
  • cleft lip and palate
  • sensorineural deafness/hearing loss
  • abnormal vertebral size/shape
  • tracheo-esophageal fistula/esophageal atresia/stenosis
  • duodenal atresia/stenosis/megaduodenum
  • annular pancreas
  • structural and functional anomalies of the spleen
  • patent ductus arteriosus
  • insterstitial/subtelomeric microdeletion/deletion
  • short stature/dwarfism/nanism
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • blepharophimosis/short palpebral fissures
  • short hand/brachydactyly
  • clinodactyly of fifth finger
  • clinodactyly of fingers 1,2,3,4/overlapping fingers
  • autosomal dominant inheritance
  • micrognathia/retrognathia/micrognathism/retrognathism
  • depressed nasal bridge
  • anteverted nares/nostrils
  • external ear anomalies
  • syndactyly of toes
  • hallux valgus
  • microcephaly

Drugs & Therapeutics for Feingold Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Feingold Syndrome

Genetic Tests for Feingold Syndrome

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22GTR
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Genetic tests related to Feingold Syndrome:

id Genetic test Affiliating Genes
1 Feingold Syndrome22

Anatomical Context for Feingold Syndrome

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32MalaCards
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MalaCards organs/tissues related to Feingold Syndrome:

32
Pancreas, Spleen, Bone

Animal Models for Feingold Syndrome or affiliated genes

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Publications for Feingold Syndrome

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Genetic Variations for Feingold Syndrome

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Feingold Syndrome:

62
id Symbol AA change Variation ID SNP ID
1MYCNp.Arg393HisVAR_031952
2MYCNp.Arg393SerVAR_031953
3MYCNp.Arg394HisVAR_031954

Expression for genes affiliated with Feingold Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Feingold Syndrome

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Pathways for genes affiliated with Feingold Syndrome

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Compounds for genes affiliated with Feingold Syndrome

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GO Terms for genes affiliated with Feingold Syndrome

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Products for genes affiliated with Feingold Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Feingold Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet