FS
MCID: FNG005
MIFTS: 44

Feingold Syndrome (FS) malady

Genetic diseases, Rare diseases, Bone diseases, Fetal diseases categories
Download this MalaCard

Summaries for Feingold Syndrome

About this section
Sources:
21Genetics Home Reference, 65Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard
Genetics Home Reference:21 Feingold syndrome is a disorder that affects many parts of the body. The signs and symptoms of this condition vary among affected individuals, even among members of the same family.

MalaCards: Feingold Syndrome, also known as brunner-winter syndrome, is related to feingold syndrome 2 and feingold syndrome 1, and has symptoms including cleft lip and palate, clinodactyly of fifth finger and blepharophimosis/short palpebral fissures. An important gene associated with Feingold Syndrome is MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog). Affiliated tissues include pancreas, spleen and bone.

Wikipedia:65 Feingold syndrome (also called oculodigitoesophagoduodenal syndrome) is a rare autosomal dominant... more...

Description from OMIM:47 164280,614326

Aliases & Classifications for Feingold Syndrome

About this section
Sources:
43NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 47OMIM, 49Orphanet, 62UMLS, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Fetal diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

49
feingold syndrome:
Inheritance: Autosomal dominant; Prevalence: <1/1000000; Age of onset: Neonatal/infancy
digital anomalies with short palpebral fissures and atresia of esophagus or duodenum type 1:
Inheritance: Autosomal dominant; Prevalence: <1/1000000; Age of onset: Neonatal/infancy; Age of death: Adult


Aliases & Descriptions:

feingold syndrome 43 22 21 47 49 62
brunner-winter syndrome 43 49
oded syndrome 43 49
digital anomalies with short palpebral fissures and atresia of esophagus or duodenum type 1 49
digital anomalies with short palpebral fissures and atresia of esophagus, or duodenum 43
digital anomalies with short palpebral fissures and atresia of esophagus or duodenum 49
microcephaly - intellectual disability - tracheoesophageal fistula type 1 49
microcephaly-mesobrachyphalangy-tracheoesophageal fistula syndrome 21
microcephaly - intellectual disability - tracheoesophageal fistula 49
microcephaly - oculo-digito-esophageal-duodenal syndrome type 1 49
microcephaly-digital anomalies-normal intelligence syndrome 49
microcephaly-digital anomalies-normal intelligence type 1 49
microcephaly - oculo-digito-esophageal-duodenal syndrome 49
microcephaly-oculo-digito-esophageal-duodenal syndrome 21
microcephaly-oculo-digito-esophageal-duodenal syndrome 43
oculo-digito-esophageal-duodenal syndrome type 1 49
oculo-digito-esophageal-duodenal syndrome 49
oculo-digito-esophagoduodental syndrome 21
oculodigitoesophagoduodenal syndrome 43
brunner-winter syndrome type 1 49
feingold syndrome type 1 49
moded syndrome type 1 49
oded syndrome type 1 49
moded syndrome 49
mmt syndrome 43
mmt type 1 49
fglds1 49
fglds 49
mmt 49
fs1 49
fs 49


External Ids:

ICD10 via Orphanet26 Q87.8

Related Diseases for Feingold Syndrome

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Feingold Syndrome family:

Feingold Syndrome 1 Feingold Syndrome 2

Diseases related to Feingold Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 27)
idRelated DiseaseScoreTop Affiliating Genes
1feingold syndrome 210.5
2feingold syndrome 110.4
3lockwood feingold syndrome10.4
4microcephaly10.3
5duodenitis10.2
6duodenal atresia10.2
7rhabdomyosarcoma10.1
8malignant mesenchymal tumor10.1
9intestinal atresia10.1
10esophageal atresia10.1
11imperforate anus10.1
12cerebritis10.1
13esophagitis10.1
14laryngitis10.1
15floating-harbor syndrome10.1
16laryngeal cleft10.1
17obsessive-compulsive disorder10.0
18inclusion body myositis10.0
19pathological gambling10.0
20breast cancer10.0
21dermatomyositis10.0
22myositis10.0
23prostatitis10.0
24sarcoma10.0
25synovial sarcoma10.0
26polymyositis10.0
27drug addiction10.0

Graphical network of the top 20 diseases related to Feingold Syndrome:



Diseases related to feingold syndrome

Symptoms for Feingold Syndrome

About this section
Sources:
47OMIM, 49Orphanet
See all sources

Symptoms by clinical synopsis from OMIM:

164280

Clinical features from OMIM:

164280,614326

Symptoms:

49 (show all 23)
  • cleft lip and palate
  • clinodactyly of fifth finger
  • blepharophimosis/short palpebral fissures
  • hallux valgus
  • structural and functional anomalies of the spleen
  • syndactyly of toes
  • duodenal atresia/stenosis/megaduodenum
  • annular pancreas
  • external ear anomalies
  • insterstitial/subtelomeric microdeletion/deletion
  • tracheo-esophageal fistula/esophageal atresia/stenosis
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • autosomal dominant inheritance
  • depressed nasal bridge
  • abnormal vertebral size/shape
  • anteverted nares/nostrils
  • sensorineural deafness/hearing loss
  • short stature/dwarfism/nanism
  • microcephaly
  • micrognathia/retrognathia/micrognathism/retrognathism
  • short hand/brachydactyly
  • patent ductus arteriosus
  • clinodactyly of fingers 1,2,3,4/overlapping fingers

Drugs & Therapeutics for Feingold Syndrome

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Feingold Syndrome

Search NIH Clinical Center for Feingold Syndrome

Genetic Tests for Feingold Syndrome

About this section
Sources:
22GTR
See all sources

Genetic tests related to Feingold Syndrome:

id Genetic test Affiliating Genes
1 Feingold Syndrome22

Anatomical Context for Feingold Syndrome

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Feingold Syndrome:

33
Pancreas, Spleen, Bone, Brain

Animal Models for Feingold Syndrome or affiliated genes

About this section

Publications for Feingold Syndrome

About this section
Sources:
52PubMed
See all sources

Articles related to Feingold Syndrome:

(show all 19)
idTitleAuthorsYear
1
A de novo 4.4-Mb microdeletion in 2p24.3 a89 p24.2 in a girl with bilateral hearing impairment, microcephaly, digit abnormalities and Feingold syndrome. (22842076)
2012
2
Dissection of the MYCN locus in Feingold syndrome and isolated oesophageal atresia. (21224895)
2011
3
Duodenal atresia: consider Feingold syndrome. (20415994)
2010
4
Cerebral and cerebellar white matter abnormalities with magnetic resonance imaging in a child with Feingold syndrome. (19921653)
2009
5
A Feingold syndrome case with previously undescribed features and a new mutation. (19852433)
2009
6
Genotype-phenotype correlations in MYCN-related Feingold syndrome. (18470948)
2008
7
Feingold syndrome associated with two novel MYCN mutations in sporadic and familial cases including monozygotic twins. (18671284)
2008
8
Expanding the clinical spectrum of MYCN-related Feingold syndrome. (16906565)
2006
9
Vertebral defects in a patient with Feingold syndrome. (16155427)
2005
10
MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome. (15821734)
2005
11
Growth deficiency in oculodigitoesophagoduodenal (Feingold) syndrome--case report and review of the literature. (15930908)
2005
12
Familial syndromic duodenal atresia: Feingold syndrome. (15185158)
2004
13
Feingold syndrome: microcephaly, esophageal atresia, type III laryngeal cleft, malrotation, limb anomalies. (15329739)
2004
14
Feingold syndrome: clinical review and genetic mapping. (14518066)
2003
15
Imperforate anus in Feingold syndrome. (10817649)
2000
16
Feingold syndrome--a cause of profound deafness. (10664710)
1999
17
Feingold syndrome: report of a new family and review. (9375923)
1997
18
Digital anomalies, microcephaly, and normal intelligence: new syndrome or Feingold syndrome? (9096751)
1997
19
Feingold Syndrome 1 (20301770)
1993

Variations for Feingold Syndrome

About this section
Sources:
64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
See all sources

UniProtKB/Swiss-Prot genetic disease variations for Feingold Syndrome:

64
id Symbol AA change Variation ID SNP ID
1MYCNp.Arg393HisVAR_031952
2MYCNp.Arg393SerVAR_031953
3MYCNp.Arg394HisVAR_031954

Clinvar genetic disease variations for Feingold Syndrome:

1
id Gene Name Type Significance SNP ID Assembly Location
1MYCNNM_005378.4(MYCN): c.1178G> A (p.Arg393His)single nucleotide variantPathogenicrs104893646GRCh37Chr 2, 16086002: 16086002
2MYCNNM_005378.4(MYCN): c.1177C> A (p.Arg393Ser)single nucleotide variantPathogenicrs104893647GRCh37Chr 2, 16086001: 16086001
3MYCNNM_005378.4(MYCN): c.1181G> A (p.Arg394His)single nucleotide variantPathogenicrs104893648GRCh37Chr 2, 16086005: 16086005
4MYCNNM_005378.4(MYCN): c.231G> A (p.Trp77Ter)single nucleotide variantPathogenicrs121913667GRCh37Chr 2, 16082417: 16082417
5MYCNNM_005378.4(MYCN): c.217G> T (p.Glu73Ter)single nucleotide variantPathogenicrs113994115GRCh37Chr 2, 16082403: 16082403
6MYCNMYCN, 1-BP DUP, 626CduplicationPathogenic
7MYCNNM_005378.4(MYCN): c.1145G> A (p.Arg382His)single nucleotide variantPathogenicrs121913666GRCh37Chr 2, 16085969: 16085969

Expression for genes affiliated with Feingold Syndrome

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Feingold Syndrome

Search GEO for disease gene expression data for Feingold Syndrome.

Pathways for genes affiliated with Feingold Syndrome

About this section

Compounds for genes affiliated with Feingold Syndrome

About this section

GO Terms for genes affiliated with Feingold Syndrome

About this section

Products for genes affiliated with Feingold Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Feingold Syndrome

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet