MMT
MCID: FNG005
MIFTS: 36

Feingold Syndrome (MMT) malady

Respiratory, Bone, Fetal categories

Summaries for Feingold Syndrome

Sources:
21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
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Genetics Home Reference:21 Feingold syndrome is a disorder that affects many parts of the body. The signs and symptoms of this condition vary among affected individuals, even among members of the same family.

MalaCards: Feingold Syndrome, also known as brunner-winter syndrome, is related to feingold syndrome 2 and feingold syndrome 1, and has symptoms including clinodactyly of fingers 1,2,3,4/overlapping fingers, intellectual deficit/mental/psychomotor retardation/learning disability and autosomal dominant inheritance. An important gene associated with Feingold Syndrome is MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog). Affiliated tissues include brain.

Wikipedia:64 Feingold syndrome (also called oculodigitoesophagoduodenal syndrome) is a rare autosomal dominant... more...

Description from OMIM:47 164280,614326

Aliases & Classifications for Feingold Syndrome

Sources:
43NIH Rare Diseases, 49Orphanet, 22GTR, 21Genetics Home Reference, 47OMIM, 61UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal
Anatomical: Respiratory, Bone


Characteristics (Orphanet epidemiological data):

49
feingold syndrome:
Inheritance: Autosomal dominant; Prevalence: <1/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

feingold syndrome 43 22 21 47 49 61
brunner-winter syndrome 43 49
digital anomalies with short palpebral fissures and atresia of esophagus, or duodenum 43
digital anomalies with short palpebral fissures and atresia of esophagus or duodenum 49
microcephaly-mesobrachyphalangy-tracheoesophageal fistula syndrome 21
microcephaly - intellectual deficit - tracheoesophageal fistula 49
microcephaly-oculo-digito-esophageal-duodenal syndrome 21
microcephaly - oculo-digito-esophageal-duodenal syndrome 49
microcephaly-oculo-digito-esophageal-duodenal syndrome 43
oculo-digito-esophageal-duodenal syndrome 49
oculo-digito-esophagoduodental syndrome 21
oculodigitoesophagoduodenal syndrome 43
moded syndrome 49
oded syndrome 49
mmt syndrome 43
mmt 49


External Ids:

ICD10 via Orphanet26 Q87.8

Related Diseases for Feingold Syndrome

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Feingold Syndrome:



Diseases related to feingold syndrome

Clinical Features for Feingold Syndrome

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

164280,614326

Clinical synopsis from OMIM:

164280

Symptoms:

49 (show all 23)
  • clinodactyly of fingers 1,2,3,4/overlapping fingers
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • autosomal dominant inheritance
  • depressed nasal bridge
  • abnormal vertebral size/shape
  • anteverted nares/nostrils
  • sensorineural deafness/hearing loss
  • short stature/dwarfism/nanism
  • microcephaly
  • micrognathia/retrognathia/micrognathism/retrognathism
  • short hand/brachydactyly
  • patent ductus arteriosus
  • tracheo-esophageal fistula/esophageal atresia/stenosis
  • insterstitial/subtelomeric microdeletion/deletion
  • clinodactyly of fifth finger
  • external ear anomalies
  • cleft lip and palate
  • blepharophimosis/short palpebral fissures
  • hallux valgus
  • structural and functional anomalies of the spleen
  • syndactyly of toes
  • duodenal atresia/stenosis/megaduodenum
  • annular pancreas

Drugs & Therapeutics for Feingold Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Feingold Syndrome

Drug clinical trials:

Search ClinicalTrials for Feingold Syndrome

Search NIH Clinical Center for Feingold Syndrome

Search CenterWatch for Feingold Syndrome

Genetic Tests for Feingold Syndrome

Sources:
22GTR
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Genetic tests related to Feingold Syndrome:

id Genetic test Affiliating Genes
1 Feingold Syndrome22

Anatomical Context for Feingold Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Feingold Syndrome:

33
Brain

Animal Models for Feingold Syndrome or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Feingold Syndrome

Sources:
51PubMed
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Articles related to Feingold Syndrome:

(show all 22)
idTitleAuthorsYear
1
De novo 13q31.1-q32.1 interstitial deletion encompassing the miR-17-92 cluster in a patient with Feingold syndrome-2. (23495052)
2013
2
A de novo 4.4-Mb microdeletion in 2p24.3 a89 p24.2 in a girl with bilateral hearing impairment, microcephaly, digit abnormalities and Feingold syndrome. (22842076)
2012
3
Dissection of the MYCN locus in Feingold syndrome and isolated oesophageal atresia. (21224895)
2011
4
Duodenal atresia: consider Feingold syndrome. (20415994)
2010
5
Cerebral and cerebellar white matter abnormalities with magnetic resonance imaging in a child with Feingold syndrome. (19921653)
2009
6
A Feingold syndrome case with previously undescribed features and a new mutation. (19852433)
2009
7
Genotype-phenotype correlations in MYCN-related Feingold syndrome. (18470948)
2008
8
End-stage renal failure, reflux nephropathy and Feingold's syndrome. (17849152)
2008
9
Feingold syndrome associated with two novel MYCN mutations in sporadic and familial cases including monozygotic twins. (18671284)
2008
10
Expanding the clinical spectrum of MYCN-related Feingold syndrome. (16906565)
2006
11
Vertebral defects in a patient with Feingold syndrome. (16155427)
2005
12
MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome. (15821734)
2005
13
Growth deficiency in oculodigitoesophagoduodenal (Feingold) syndrome--case report and review of the literature. (15930908)
2005
14
Familial syndromic duodenal atresia: Feingold syndrome. (15185158)
2004
15
Feingold syndrome: microcephaly, esophageal atresia, type III laryngeal cleft, malrotation, limb anomalies. (15329739)
2004
16
Feingold syndrome: clinical review and genetic mapping. (14518066)
2003
17
Imperforate anus in Feingold syndrome. (10817649)
2000
18
Feingold syndrome--a cause of profound deafness. (10664710)
1999
19
Feingold syndrome: report of a new family and review. (9375923)
1997
20
Digital anomalies, microcephaly, and normal intelligence: new syndrome or Feingold syndrome? (9096751)
1997
21
Feingold Syndrome 1 (20301770)
1993
22
Gellis SS, Feingold M: Picture of the month: Crano-carpo-tarsal dystrophy. (Whistling face syndrome, Freeman-Sheldon Syndrome). (5434592)
1970

Genetic Variations for Feingold Syndrome

Sources:
63UniProtKB/Swiss-Prot
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Genetic disease variations for Feingold Syndrome:

63
id Symbol AA change Variation SNP ID
1MYCNp.Arg393HisVAR_031952
2MYCNp.Arg393SerVAR_031953
3MYCNp.Arg394HisVAR_031954

Expression for genes affiliated with Feingold Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Feingold Syndrome

Search GEO for disease gene expression data for Feingold Syndrome.

Pathways for genes affiliated with Feingold Syndrome

Compounds for genes affiliated with Feingold Syndrome

GO Terms for genes affiliated with Feingold Syndrome

Products for genes affiliated with Feingold Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Feingold Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet