MCID: FLT001
MIFTS: 53

Felty's Syndrome malady

Categories: Genetic diseases, Rare diseases, Bone diseases, Blood diseases

Aliases & Classifications for Felty's Syndrome

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet, 61The Human Phenotype Ontology
See all MalaCards sources

Aliases & Descriptions for Felty's Syndrome:

Name: Felty's Syndrome 10 45 12
Felty Syndrome 10 45 51 36 65
Familial Felty's Syndrome 45 65
Rheumatoid Arthritis with Splenoadenomegaly and Leukopenia 10
 
Splenomegaly-Neutropenia-Rheumatoid Arthritis Syndrome 51
Rheumatoid Arthritis, Splenomegaly and Neutropenia 45
Feltys Syndrome 47

Characteristics:

Orphanet epidemiological data:

51
felty syndrome:
Age of onset: Adult; Age of death: elderly


Classifications:



External Ids:

Disease Ontology10 DOID:11042
ICD1027 M05.0, M05.00
ICD9CM29 714.1
MeSH36 D005258
NCIt42 C84712
SNOMED-CT59 156482001, 57160007
Orphanet51 47612
UMLS via Orphanet66 C0015773
ICD10 via Orphanet28 M05.0
MESH via Orphanet37 D005258
UMLS65 C0015773, C2936659

Summaries for Felty's Syndrome

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NIH Rare Diseases:45 Felty's syndrome is a rare, potentially serious disorder that is defined by the presence of three conditions: rheumatoid arthritis (ra), an enlarged spleen (splenomegaly) and a decreased white blood cell count (neutropenia), which causes repeated infections. although some individuals with felty's syndrome are asymptomatic, others can develop serious and life-threatening infections. symptoms of felty's syndrome, in addition to those associated with the three conditions stated above, may include fatigue, fever, weight loss, discoloration of patches of skin, mild hepatomegaly (enlarged liver), lymphadenopathy (swelling of lymph nodes), sjögren syndrome, vasculitis, lower-extremity ulcers, and other findings. the exact cause is unknown, but several risk factors have been proposed, including autoimmunity. a few familial cases of the condition have been reported. treatment typically focuses on controlling the underlying ra; immunosuppressive therapy for ra may improve neutropenia and splenomegaly. last updated: 2/21/2016

MalaCards based summary: Felty's Syndrome, also known as felty syndrome, is related to parasitic ichthyosporea infectious disease and laryngeal abductor paralysis mental retardation, and has symptoms including autoimmunity, arthralgia and osteolysis. An important gene associated with Felty's Syndrome is C4A (Complement Component 4A (Rodgers Blood Group)), and among its related pathways are Cytokines and Inflammatory Response and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. Affiliated tissues include skin, liver and bone.

Disease Ontology:10 A syndrome that results in rheumatoid arthritis, splenomegaly and neutropenia.

Wikipedia:68 Felty\'s syndrome, also called Felty syndrome, is characterized by the combination of rheumatoid... more...

Related Diseases for Felty's Syndrome

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Diseases related to Felty's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1parasitic ichthyosporea infectious disease10.4CSF2, CSF3
2laryngeal abductor paralysis mental retardation10.3CSF2, CSF3
3gastroparesis10.3CSF2, CSF3
4critical illness polyneuropathy10.3C4A, CSF2
5corneal dystrophy10.3CSF2, CSF3
6lattice corneal dystrophy10.3CSF2, IL3
7trichosporonosis10.2CSF2, CSF3
8loeffler syndrome10.2CSF2, IL3
9papillary adenoma10.2CSF2, IL3
10chorea gravidarum10.2C4A, TNFRSF10A
11al gazali aziz salem syndrome10.1CSF3, IL3
12retroperitoneal germ cell neoplasm10.1CSF2, IL3
13sulfhemoglobinemia10.0CSF2, CSF3
14chronic inflammatory demyelinating polyneuropathy10.0CSF2, CSF3
15hemochromatosis10.0C4A, C4B
16alopecia antibody deficiency10.0C4A, C4B
17siderosis of eye10.0C4A, C4B
18aapoai amyloidosis10.0C4A, C4B
19hereditary sensory neuropathy10.0C4A, C4B
20epidemic pleurodynia10.0C4A, C4B
21melanoma metastasis10.0CSF2, IL3
22granulomas, congenital cerebral9.9CSF2, CSF3, IL3
23neutropenia, severe congenital 1, autosomal dominant9.9CSF2, CSF3, IL3
24neonatal anemia9.9CSF2, CSF3, IL3
25chronic eosinophilic pneumonia9.9CSF2, CSF3, IL3
26cell type benign neoplasm9.9CSF2, CSF3, IL3
27silicosis9.9CSF2, CSF3, IL3
28pericardial tuberculosis9.9CSF2, CSF3, IL3
29agammaglobulinemia 29.9CSF2, CSF3, IL3
30hematopoietic stem cell transplantation9.9CSF2, CSF3, IL3
31vitreous detachment9.9C4A, C4B
32newborn respiratory distress syndrome9.9CSF2, CSF3, IL3
33trichorhinophalangeal syndrome, type iii9.9C4A, C4B
34smoking as a quantitative trait locus 19.9CSF2, CSF3, IL3
35rheumatoid arthritis9.9
36arthritis9.9
37leukemia9.9
38juvenile rheumatoid arthritis9.9
39large granular lymphocyte leukemia9.9
40hypocalciuric hypercalcemia, type i9.8CSF2, CSF3, IL3
41choroiditis9.8CSF2, IL3
42acute monocytic leukemia9.7CSF2, CSF3
43neutropenia9.7
44histoplasmosis9.7
45leukemia, acute myeloid9.7CSF2, CSF3, IL3
46myelodysplastic syndrome9.6CSF2, CSF3, IL3
47gastroschisis7.7B3GAT1, C4A, C4B, CSF2, CSF3, IL3

Comorbidity relations with Felty's Syndrome via Phenotypic Disease Network (PDN):


Rheumatoid ArthritisDeficiency Anemia
NeutropeniaHeart Disease
Acute Cystitis

Graphical network of the top 20 diseases related to Felty's Syndrome:



Diseases related to felty's syndrome

Symptoms for Felty's Syndrome

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Symptoms:

 51 (show all 35)
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • repeat respiratory infections
  • osteolysis/osteoclasia/bone destruction/erosions
  • articular/joint pain/arthralgia
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • joint/articular deformation
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • autoimmunity/autoimmune reaction/autoantibodies
  • polynuclear cells/neutrophils anomalies/neutropenia
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • chronic/relapsing otitis
  • pharyngitis
  • splenomegaly
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • lymphadenopathy/polyadenopathies
  • anaemia
  • lymphocytes anomalies
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue
  • chronic skin infection/ulcerations/ulcers/cancrum
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • irregular/in bands/reticular skin hyperpigmentation
  • hepatomegaly/liver enlargement (excluding storage disease)
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • lung fibrosis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • recurrent urinary infections
  • peripheral neuropathy
  • bone marrow failure/pancytopenia
  • thrombocytopenia/thrombopenia
  • lymphoma
  • early death/lethality
  • sepsis severe/septicemia

HPO human phenotypes related to Felty's Syndrome:

(show all 32)
id Description Frequency HPO Source Accession
1 autoimmunity hallmark (90%) HP:0002960
2 arthralgia hallmark (90%) HP:0002829
3 osteolysis hallmark (90%) HP:0002797
4 abnormality of neutrophils hallmark (90%) HP:0001874
5 limitation of joint mobility hallmark (90%) HP:0001376
6 arthritis hallmark (90%) HP:0001369
7 recurrent pharyngitis typical (50%) HP:0100776
8 abnormality of lymphocytes typical (50%) HP:0004332
9 lymphadenopathy typical (50%) HP:0002716
10 anemia typical (50%) HP:0001903
11 weight loss typical (50%) HP:0001824
12 splenomegaly typical (50%) HP:0001744
13 otitis media typical (50%) HP:0000388
14 sinusitis typical (50%) HP:0000246
15 skin ulcer occasional (7.5%) HP:0200042
16 sepsis occasional (7.5%) HP:0100806
17 cellulitis occasional (7.5%) HP:0100658
18 inflammatory abnormality of the eye occasional (7.5%) HP:0100533
19 peripheral neuropathy occasional (7.5%) HP:0009830
20 generalized hyperpigmentation occasional (7.5%) HP:0007440
21 irregular hyperpigmentation occasional (7.5%) HP:0007400
22 bone marrow hypocellularity occasional (7.5%) HP:0005528
23 lymphoma occasional (7.5%) HP:0002665
24 hepatomegaly occasional (7.5%) HP:0002240
25 pulmonary fibrosis occasional (7.5%) HP:0002206
26 abnormality of the pleura occasional (7.5%) HP:0002103
27 thrombocytopenia occasional (7.5%) HP:0001873
28 abnormality of the pericardium occasional (7.5%) HP:0001697
29 recurrent urinary tract infections occasional (7.5%) HP:0000010
30 neutropenia HP:0001875
31 splenomegaly HP:0001744
32 rheumatoid arthritis HP:0001370

Drugs & Therapeutics for Felty's Syndrome

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Drugs for Felty's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Cyclophosphamideapproved, investigationalPhase 2264350-18-0, 6055-19-22907
Synonyms:
(+-)-Cyclophosphamide
(-)-Cyclophosphamide
(RS)-Cyclophosphamide
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
4-Hydroxy-cyclophosphan-mamophosphatide
50-18-0
60007-95-6
6055-19-2 (monohydrate)
75526-90-8
AC1L1EQQ
AI3-26198
ASTA
ASTA B518
Asta B 518
B 518
B-518
BRN 0011744
BSPBio_002099
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
C 0768
C07888
C7H15Cl2N2O2P
CB 4564
CB-4564
CCRIS 188
CHEBI:4027
CHEMBL32520
CHEMBL88
CID2907
CP
CPA
CTX
CY
Ciclofosfamida
Ciclofosfamida [INN-Spanish]
Ciclofosfamide
Ciclophosphamide
Ciclophosphamide [INN]
Clafen
Claphene
Cycloblastin
Cyclophosphamid
Cyclophosphamide
Cyclophosphamide (INN)
Cyclophosphamide (TN)
Cyclophosphamide (anhydrous form)
Cyclophosphamide (anhydrous)
Cyclophosphamide Monohydrate
Cyclophosphamide Sterile
Cyclophosphamide anhydrous
Cyclophosphamide, (+-)-Isomer
Cyclophosphamides
Cyclophosphamidum
Cyclophosphamidum [INN-Latin]
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclophosphoramide
Cyclostin
Cyklofosfamid
Cyklofosfamid [Czech]
Cytophosphan
Cytophosphane
Cytoxan
Cytoxan (TN)
Cytoxan Lyoph
D,L-Cyclophosphamide
D07760
DB00531
 
DivK1c_000246
EINECS 200-015-4
EU-0100238
Endoxan
Endoxan R
Endoxan-Asta
Endoxana
Endoxanal
Endoxane
Enduxan
Genoxal
HMS2090A12
HSDB 3047
Hexadrin
IDI1_000246
KBio1_000246
KBio2_001338
KBio2_003906
KBio2_006474
KBio3_001319
KBioGR_000888
KBioSS_001338
LS-1302
LS-99787
Ledoxina
Lopac-C-0768
Lopac0_000238
Lyophilized Cytoxan
Mitoxan
MolPort-001-783-420
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
NCGC00015209-01
NCGC00015209-03
NCGC00015209-06
NCGC00091741-02
NCGC00091741-03
NCI-C04900
NCI60_002097
NINDS_000246
NSC 26271
NSC-26271
NSC26271
NSC273033
NSC273034
Neosar
Occupation, cyclophosphamide exposure
Procytox
RCRA waste no. U058
Rcra Waste Number U058
Rcra waste number U058
Revimmune
S1217_Selleck
SK 20501
SPBio_001071
STK177249
STOCK2S-91217
Semdoxan
Sendoxan
Senduxan
Spectrum2_001146
Spectrum3_000370
Spectrum4_000304
Spectrum5_000795
Spectrum_000858
UNII-6UXW23996M
WLN: T6MPOTJ BO BN2G2G
Zyklophosphamid
Zyklophosphamid [German]
bis(2-Chloroethyl)phosphami de cyclic propanolamide
bis(2-Chloroethyl)phosphamide cyclic propanolamide ester
cyclophosphamide
2Immunosuppressive AgentsPhase 2, Phase 110422
3Alkylating AgentsPhase 23582
4Immunologic FactorsPhase 2, Phase 118483
5lenograstimPhase 21134
6Antirheumatic AgentsPhase 2, Phase 18496
7Antineoplastic Agents, AlkylatingPhase 23406
8
TetracyclineapprovedPhase 18960-54-85280962, 5353990
Synonyms:
(-)-Tetracycline
(4S,4AS,5as,12as)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
6-Methyl-1,11-dioxy-2-naphthacenecarboxamide
60-54-8
64-75-5 (mono-hydrochloride)
6591-49-7
87128_FLUKA
87128_SIGMA
AC-13151
AC1L1KAT
AC1NQXT7
AC1NRDAM
AC1NS4RQ
AC1NSDX8
AC1NTUT2
AC1NUZHL
AC1O52HS
Abramycin
Abricycline
Achromycin
Achromycin (naphthacene derivative)
Achromycin V
Achromycin, naphthacene derivative
Agromicina
Ambramicina
Ambramycin
Amycin
Anhydrotetracycline
BIDD:GT0653
BPBio1_000242
BSPBio_000220
BSPBio_001950
Bio-tetra
Biocycline
Bristaciclin
Bristaciclin .alpha.
Bristaciclina
Bristacycline
C06570
CHEBI:27902
CHEMBL1440
CID12309720
CID5280962
CID5289435
CID5353990
CID5359245
CID5388997
CID5412
CID5497101
CID6426717
Cefracycline
Cefracycline suspension
Centet (base)
Ciclibion
Copharlan
Criseociclina
Cyclomycin
Cyclopar
Cytome
D00201
DB00759
Democracin
Deschlorobiomycin
DivK1c_000827
Dumocyclin
EINECS 200-481-9
Enterocycline
HMS2090B04
HSDB 3188
Hostacyclin
IDI1_000827
KBio1_000827
KBio2_001514
KBio2_004082
KBio2_006650
KBio3_001450
KBioGR_000783
KBioSS_001514
LS-187078
LS-93869
Lemtrex (base)
Lexacycline
Limecycline
Liquamycin
Liquamycin (Veterinary)
Liquamycin, veterinary
MLS000069728
 
Medocycline
Mericycline
Micycline
MolPort-001-794-633
MolPort-003-983-460
MolPort-005-934-198
NCGC00161665-01
NINDS_000827
NSC 108579
NSC108579
Neocycline
Omegamycin
Orlycycline
Panmycin
Piracaps (base)
Polycycline
Polycycline (VAN)
Polycycline (antibiotic)
Polycycline, antibiotic
Polyotic
Prestwick0_000140
Prestwick1_000140
Prestwick2_000140
Prestwick3_000140
Purocyclina
Resteclin
Robitet
Roviciclina
SK-Tetracycline
SMR000058220
SPBio_001457
SPBio_002159
STOCK1N-42738
Sanclomycine
Solvocin
Spectrum2_001329
Spectrum3_000565
Spectrum4_000352
Spectrum5_001112
Spectrum_001034
Sumycin
Sumycin (TN)
Sumycin syrup
T-125
T3258_SIGMA
TETRACYCLINE
Tetra-Co
Tetrabon
Tetrachel
Tetraciclina
Tetraciclina [INN-Spanish]
Tetracycl
Tetracyclin
Tetracycline
Tetracycline & VRC3375
Tetracycline (JAN/USP/INN)
Tetracycline (internal use)
Tetracycline Free Base
Tetracycline HCl
Tetracycline Hydrochloride
Tetracycline I
Tetracycline II
Tetracycline Monohydrochloride
Tetracycline [USAN:INN:BAN:JAN]
Tetracycline hydrochloride
Tetracyclinum
Tetracyclinum [INN-Latin]
Tetracyn
Tetradecin
Tetrafil
Tetraverine
Tetrazyklin
Topicycline
Tsiklomistsin
Tsiklomitsin
UNII-F8VB5M810T
UPCMLD-DP127
UPCMLD-DP127:001
UPCMLD-DP127:002
Veracin
Vetacyclinum
Vetquamycin-324 (free base)
WLN: L E6 C666 BV FV CU GUTTT&J DQ EQ GVZ HQ IN1&1 MQ M1 RQ
component of Tetrastatin
methyl-1,11-dioxo-2-naphthacenecarboxamide
nchembio.273-comp1
nchembio.289-comp1
tetracycline
9
MethotrexateapprovedPhase 114441959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
Methopterin
Methotextrate
 
Methotrate
Methotrexat
Methotrexate
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metoject
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Otrexup
Rasuvo
Rheumatrex
Rheumatrex Dose Pack
Trexall
10
Etanerceptapproved, investigationalPhase 1383185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
11
Cholecalciferolapproved, nutraceuticalPhase 179967-97-06221, 10883523, 5280795
Synonyms:
()-Vitamin D3
(+)-Vitamin D3
(+)-vitamin D3
(1S,3Z)-3-[(2e)-2-[(1R,3AR,7as)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(3beta,5Z,7e)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
(3beta,Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
(5E,7E)-9,10-Secocholesta-5,7,10-trien-3-ol
(5Z,7E)-(3S)-9,10-seco-5,7,10(19)-cholestatrien-3-ol
(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(5Z,7e)-(3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
1406-16-2
25(OH)D
3-beta,Z,7E-9,10-Secocholestr-5,7,10(19)-trien-3-ol
47763_SUPELCO
57651-82-8
67-97-0
7-Dehydrocholesterol activated
7-Dehydrocholesterol, Activated
7-Dehydrocholesterol, irradiated
7-Dehydrocholestrol, activated
8024-19-9
8050-67-7
89193_FLUKA
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3-ol
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3beta-ol
9,10-Secocholesta-5(Z),7(E),10(19)-trien-3(.beta.)-ol
9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol
9,10-Secocholesta-5,7,10(19)-trien-3-ol
9,10-Secocholesta-5,7,10-trien-3-ol
AB1002422
AC-11697
AC1L1ECK
AC1L1M23
AC1LU7IZ
AC1NQXLN
AC1NR2UO
AC1NR2UR
AC1NR2UU
AC1NS4AJ
AC1NSHJX
AC1O5EOF
AC1O7GAV
AC1O7GQ3
AC1O8FEU
AC1O8PWJ
AC1OF2GI
AC1OF2GL
AC1OIEW5
AC1OIEWB
ACon1_001997
Activated 7-dehydrocholesterol
Arachitol
BPBio1_000460
BSPBio_000418
BSPBio_002408
Bio-0845
C05443
C1357_SIAL
C27H44O
C9756_SIGMA
C9774_SIAL
CAS-67-97-0
CC
CCRIS 5813
CCRIS 6286
CHEBI:283119
CHEBI:28940
CHEMBL1042
CHEMBL432780
CID10000117
CID10045875
CID10340013
CID10883523
CID10894379
CID11014566
CID11025493
CID11058152
CID11463269
CID1548921
CID2735
CID5280795
CID5283710
CID5283711
CID5283712
CID5353527
CID5363362
CID6221
CID6432644
CID6604201
CID6604662
CID6708595
CID6713938
CID6992015
CID6992016
CID7067439
CID7067440
CID7251172
CID7251174
CID9821465
Calciol
Cholecalciferol
Cholecalciferol (D3)
Cholecalciferol (JP15/USP)
Cholecalciferol D3
Cholecalciferol [USAN:BAN:JAN]
Cholecalciferol, D3
Cholecalciferolum
 
Colecalciferol
Colecalciferol (INN)
Colecalciferolo
Colecalciferolo [DCIT]
Colecalciferolum
Colecalciferolum [INN-Latin]
Colecalcipherol
D00188
D3-Vicotrat
D3-Vigantol
DB00169
Delsterol
Delta-D
Delta-D (TN)
Deparal
Devaron
DivK1c_006276
Duphafral D3 1000
EINECS 200-673-2
EINECS 215-797-2
EPA Pesticide Chemical Code 202901
Ebivit
FeraCol
Granuvit D3
HMS1569E20
HMS2092M12
HSDB 820
I05-0041
Irradiated 7-dehydrocholesterol
KBio1_001220
KBio2_001643
KBio2_004211
KBio2_006779
KBio3_001628
KBioGR_001602
KBioSS_001643
LMST03020001
LMST03020219
LMST03020220
LMST03020221
LS-1570
LS-825
LT00244775
MEGxm0_000458
Micro-dee
MolPort-001-740-051
MolPort-001-785-972
MolPort-003-666-021
MolPort-004-946-964
NCGC00016301-01
NCGC00017328-01
NCGC00091072-01
NCGC00142511-01
NCGC00159331-02
NCGC00159331-04
NCGC00178668-01
NCGC00179565-01
NCGC00179565-02
NEO Dohyfral D3
NSC 375571
NSC-375571
NSC375571
Oleovitamin D3
Prestwick0_000429
Prestwick1_000429
Prestwick2_000429
Prestwick3_000429
Prestwick_63
Provitamine
Provitina
Quintox
Rampage
Ricketon
SMP1_000068
SPBio_001298
SPBio_002357
SR-05000001559
SR-05000001559-3
ST057172
SpecPlus_000180
Spectrum2_001369
Spectrum3_000764
Spectrum4_001201
Spectrum_001163
TNP00266
Trivitan
UNII-1C6V77QF41
UPCMLD-DP152
UPCMLD-DP152:001
VITAMIN D
VITAMIN D3 POWDER
VITAMIN_D3
Vi-De3
Vi-de-3-hydrosol
VidDe-3-hydrosol
Videkhol
Vigantol
Vigorsan
Vitamin D3
Vitamin D3 emulsifiable
Vitinc Dan-Dee-3
ZINC04474460
ZINC04492874
ZINC04492875
ZINC04492876
ZINC04492878
bmse000507
calciol
cholecalciferol
delta-D
vitamin d-3
12
Folic Acidapproved, nutraceuticalPhase 1292459-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
13Gastrointestinal AgentsPhase 16401
14Folic Acid AntagonistsPhase 11643
15Trace ElementsPhase 13900
16vitamin dPhase 11524
17VitaminsPhase 13857
18Vitamin B ComplexPhase 12847
19Peripheral Nervous System AgentsPhase 118510
20Nucleic Acid Synthesis InhibitorsPhase 13836
21MicronutrientsPhase 13901
22Bone Density Conservation AgentsPhase 12600
23Anti-Infective AgentsPhase 117220
24Anti-Inflammatory AgentsPhase 18478
25Anti-Bacterial AgentsPhase 19140
26Analgesics, Non-NarcoticPhase 15184
27AcyclovirPhase 1153
28AnalgesicsPhase 19358
29Anti-Inflammatory Agents, Non-SteroidalPhase 13549
30AntimetabolitesPhase 19454
31Atorvastatin CalciumPhase 1714134523-03-8
32Dermatologic AgentsPhase 14555
33Antiviral AgentsPhase 18071
34Antimetabolites, AntineoplasticPhase 15770
35FolateNutraceuticalPhase 12924
36CalciferolNutraceuticalPhase 11074
37Folinic AcidNutraceuticalPhase 12604
38Vitamin B9NutraceuticalPhase 12924

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phase II Study of High-Dose Cyclophosphamide in Patients With Severe Autoimmune Hematologic DiseaseCompletedNCT00010387Phase 2
2Use of Well Known Drugs for New Destination - RA Improvement (RANT)CompletedNCT02633332Phase 1

Search NIH Clinical Center for Felty's Syndrome


Cochrane evidence based reviews: felty syndrome

Genetic Tests for Felty's Syndrome

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Anatomical Context for Felty's Syndrome

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MalaCards organs/tissues related to Felty's Syndrome:

33
Skin, Liver, Bone, Spleen, Neutrophil, Lymph node, Bone marrow

Animal Models for Felty's Syndrome or affiliated genes

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Publications for Felty's Syndrome

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Articles related to Felty's Syndrome:

(show top 50)    (show all 339)
idTitleAuthorsYear
1
Felty's syndrome with hyperthyroidism: a case report and literature review. (24472276)
2014
2
Neutrophil activation and B-cell stimulation in the pathogenesis of Felty's syndrome. (22814518)
2012
3
Felty's syndrome as an initial presentation of rheumatoid arthritis: a case report. (19946450)
2009
4
Efficacy of rituximab in Felty's syndrome. (18697782)
2008
5
Felty's syndrome with chronic hepatitis and compatible autoimmune hepatitis: a case presentation. (15897648)
2005
6
Felty's syndrome. (15454123)
2004
7
Autoantibodies against granulocyte-macrophage colony stimulating factor and interleukin-3 are rare in patients with Felty's syndrome. (15194585)
2004
8
Autoantibodies against granulocyte colony-stimulating factor in Felty's syndrome and neutropenic systemic lupus erythematosus. (12355486)
2002
9
Major histocompatility complex haplotypic associations in Felty's syndrome and large granular lymphocyte syndrome are secondary to allelic association with HLA-DRB1 *0401. (10817772)
2000
10
Pulmonary veno-occlusive disease complicating Felty's syndrome. (9893784)
1998
11
Treatment of Felty's syndrome with the haemopoietic growth factor granulocyte colony-stimulating factor (G-CSF). (9519212)
1998
12
Interleukin-10 promoter polymorphisms in rheumatoid arthritis and Felty's syndrome. (9783765)
1998
13
Prolonged treatment with granulocyte colony-stimulating factor in a patient with Felty's syndrome and chronic renal failure from secondary amyloidosis. (9269662)
1997
14
Successful treatment of agranulocytosis and sepsis with granulocyte colony stimulating factor in a case of Felty's syndrome. (8523369)
1995
15
Felty's syndrome treated with rhG-CSF associated with flare of arthritis and skin rash. (7540527)
1995
16
Indication for and caution in the use of granulocyte colony-stimulating factor for the treatment of Felty's syndrome: comment on the report by Yasuda et al. (7524509)
1994
17
Orbital lymphoma in a patient with Felty's syndrome. (1540565)
1992
18
DR-DQ variants in rheumatoid arthritis and Felty's syndrome: comment on the article by Wallin et al. (1622429)
1992
19
Digital vasculitis after splenectomy in a patient with Felty's syndrome. (1632669)
1992
20
Analysis of lymphocyte phenotype and T cell receptor genotype in Felty's syndrome. (1380988)
1992
21
Effect of corticosteroid treatment on hemopoiesis in vivo and in vitro in a patient with Felty's syndrome. (1786345)
1991
22
Ectopic splenomegaly in Felty's syndrome. (2032427)
1991
23
Worsening of Felty's syndrome with methotrexate. (1929594)
1991
24
Is there a place for splenectomy in the treatment of Felty's syndrome? (2306569)
1990
25
Resolution of Felty's syndrome with cyclophosphamide. (2754676)
1989
26
Felty's syndrome: a therapeutic dilemma? (2769662)
1989
27
Neutropenia and infections in Felty's syndrome. (3378123)
1988
28
Felty's syndrome in black Americans: a case report. (3594967)
1987
29
Simultaneous presentation of rheumatoid arthritis and acute myeloid leukaemia masquerading as Felty's syndrome. (3465419)
1986
30
Radiocolloid scintigraphy in Felty's syndrome. (3487213)
1986
31
Treatment of Felty's syndrome with low-dose oral methotrexate. (3741502)
1986
32
HLA-DR4 in Felty's syndrome. (3876440)
1985
33
Felty's syndrome in an Asian. (4016489)
1985
34
D-penicillamine in Felty's syndrome. (4057191)
1985
35
Felty's syndrome in a child. (6520839)
1984
36
Kingella kingae causing septic arthritis in Felty's syndrome. (6622347)
1983
37
High-dose immunoglobulin in Felty's syndrome. (6882047)
1983
38
HLA-DRw4 in Felty's syndrome. (6934775)
1980
39
Felty's syndrome: granulocyte-bound immunoglobulin G and splenectomy. (970768)
1976
40
Letter: Lithium in Felty's syndrome. (1259276)
1976
41
Familial Felty's syndrome. (984910)
1976
42
Spontaneous remission of Felty's syndrome. (1191353)
1975
43
Splenectomy and Felty's syndrome. (1146350)
1975
44
The mechanism of neutropenia in Felty's syndrome. (4416356)
1974
45
Symptomatic porphyria in a case of Felty's syndrome. I. Clinical and routine biochemcial studies. (5019121)
1972
46
Symptomatic porphyria in a case of Felty's syndrome. II. Biochemical investigations. (5019122)
1972
47
Leucocyte-specific anti-nuclear factors in patients with felty's syndrome, rheumatoid arthritis, systemic lupus erythematosus and other diseases. (5325973)
1966
48
Felty's syndrome; response to splenectomy after cortisone failure. (13227656)
1955
49
Neutropenia associated with splenomegaly and atrophic arthritis (Felty's syndrome); report of a case in which splenectomy was performed. (15411128)
1950
50
Primary splenic neutropenia with rheumatoid arthritis. (Felty's syndrome). (15427053)
1950

Variations for Felty's Syndrome

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Expression for genes affiliated with Felty's Syndrome

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Search GEO for disease gene expression data for Felty's Syndrome.

Pathways for genes affiliated with Felty's Syndrome

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GO Terms for genes affiliated with Felty's Syndrome

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Biological processes related to Felty's Syndrome according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.1CSF2, IL3
2positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.0CSF3, IL3
3positive regulation of DNA replicationGO:00457409.8CSF2, IL3
4regulation of complement activationGO:00304499.7C4A, C4B
5complement activationGO:00069569.6C4A, C4B
6negative regulation of endopeptidase activityGO:00109519.6C4A, C4B
7immune responseGO:00069559.0CSF2, CSF3, IL3
8positive regulation of cell proliferationGO:00082848.8CSF2, CSF3, IL3
9innate immune responseGO:00450878.3C4A, C4B, CSF2, IL3

Molecular functions related to Felty's Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00048669.3C4A, C4B

Sources for Felty's Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet