MCID: FLT001
MIFTS: 63

Felty's Syndrome malady

Genetic diseases, Rare diseases, Bone diseases, Blood diseases categories

Summaries for Felty's Syndrome

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9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Felty's syndrome is a rare, potentially serious disorder that is defined by the presence of three conditions: rheumatoid arthritis (ra), an enlarged spleen (splenomegaly) and a decreased white blood cell count (neutropenia), which causes repeated infections. although some individuals with felty's syndrome are asymptomatic, others can develop serious and life-threatening infections. symptoms of felty's syndrome, in addition to those associated with the three conditions stated above, may include fatigue, fever, weight loss, discoloration of patches of skin, mild hepatomegaly (enlarged liver), lymphadenopathy (swelling of lymph nodes), sjögren syndrome, vasculitis, lower-extremity ulcers, and other findings. the exact cause is unknown, but several risk factors have been proposed, including autoimmunity. a few familial cases of the condition have been reported. treatment typically focuses on controlling the underlying ra; immunosuppressive therapy for ra may improve neutropenia and splenomegaly. last updated: 1/6/2011

MalaCards: Felty's Syndrome, also known as felty syndrome, is related to arthritis and leukemia, and has symptoms including restricted joint mobility/joint stiffness/ankylosis, abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax and lung fibrosis. An important gene associated with Felty's Syndrome is CSF2 (colony stimulating factor 2 (granulocyte-macrophage)), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Staphylococcus aureus infection. The compounds bmmp and as 101 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spleen, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Disease Ontology:9 A syndrome that results in rheumatoid arthritis, splenomegaly and neutropenia.

Wikipedia:66 Felty\'s syndrome, also called Felty syndrome, is characterized by the combination of rheumatoid... more...

Description from OMIM:48 134750

Aliases & Classifications for Felty's Syndrome

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9Disease Ontology, 44NIH Rare Diseases, 63UMLS, 50Orphanet, 48OMIM, 11DISEASES, 46Novoseek, 28ICD9CM, 41NCIt, 59SNOMED-CT, 36MeSH, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Bone diseases, Blood diseases


Characteristics (Orphanet epidemiological data):

50
felty syndrome:
Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

felty's syndrome 9 44 63
felty syndrome 9 44 50 48
familial felty's syndrome 44 63
feltys syndrome 11 46
rheumatoid arthritis with splenoadenomegaly and leukopenia 9
splenomegaly-neutropenia-rheumatoid arthritis syndrome 50
rheumatoid arthritis, splenomegaly and neutropenia 44


External Ids:

Disease Ontology9 DOID:11042
OMIM48 134750
ICD9CM28 714.1
NCIt41 C84712
MeSH36 D005258
SNOMED-CT59 57160007, 156482001
MESH via Orphanet37 D005258
ICD10 via Orphanet27 M05.0
SNOMED-CT via Orphanet60 57160007
UMLS via Orphanet64 C0015773
ICD1026 M05.0

Related Diseases for Felty's Syndrome

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Felty's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.2IL10, CSF2, IL8
2leukemia30.1EEF1A1, IL3, CSF2, CSF3, TRA
3rheumatoid arthritis30.1CSF2, TRA, IL10, IL8
4neutropenia30.0CSF3, IL3, CSF2
5juvenile rheumatoid arthritis10.2
6large granular lymphocyte leukemia10.2
7capillary leak syndrome10.1CSF2
8meningitis10.1IL8
9chronic myelomonocytic leukemia10.1CSF3, CSF2
10lung cancer10.1CSF3, CSF2
11stomatitis10.1CSF3, CSF2
12myelofibrosis10.0IL3, CSF3
13factor vii deficiency10.0CSF3, CSF2
14pulmonary alveolar proteinosis10.0IL3, CSF2
15megakaryocytic leukemia10.0IL3, CSF2
16vernal keratoconjunctivitis10.0IL8, IL3
17histoplasmosis10.0
18acute graft versus host disease10.0IL10, CSF3
19monocytic leukemia10.0IL8, CSF2
20alcoholic hepatitis10.0IL10, IL8
21diphtheria10.0CSF2, IL3
22severe congenital neutropenia autosomal recessive 310.0CSF3, CSF2, IL3
23cyclic hematopoiesis10.0CSF3, IL3, CSF2
24leukemoid reaction10.0IL3, CSF2, CSF3
25severe congenital neutropenia10.0CSF2, IL3, CSF3
26pancytopenia10.0IL3, CSF2, CSF3
27refractory anemia10.0IL3, CSF3, CSF2
28thrombocytosis10.0CSF2, CSF3, IL3
29aplastic anemia10.0IL3, CSF2, CSF3
30leukopenia10.0IL3, CSF3, CSF2
31myeloproliferative disorder10.0CSF3, CSF2, IL3
32lupus nephritis10.0IL10, TRA
33thrombocytopenia10.0IL3, CSF2, CSF3
34hematologic cancer10.0IL3, CSF3, CSF2
35hodgkin's lymphoma10.0IL3, CSF3, CSF2
36chronic myeloid leukemia10.0CSF2, IL3, CSF3
37deficiency anemia10.0IL3, CSF2, CSF3
38non-hodgkin lymphoma10.0IL3, CSF2, CSF3
39acute leukemia10.0CSF3, CSF2, IL3
40acute lymphocytic leukemia10.0IL3, CSF2, CSF3
41myeloid leukemia10.0CSF3, CSF2, IL3
42myeloma10.0CSF2, IL3, CSF3
43periodontitis10.0IL8, IL10
44tetanus10.0IL10, CSF2
45septic shock10.0CSF3, IL10, IL8
46acute promyelocytic leukemia10.0CSF3, IL3
47non-small cell lung carcinoma10.0CSF2, IL3, CSF3
48acute pancreatitis10.0IL8, IL10
49allergic rhinitis10.0IL8, IL10, CSF2
50ulcerative colitis10.0IL8, IL10, TRA

Graphical network of the top 20 diseases related to Felty's Syndrome:



Diseases related to felty's syndrome

Symptoms for Felty's Syndrome

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48OMIM, 50Orphanet
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Symptoms by clinical synopsis from OMIM:

134750

Clinical features from OMIM:

134750

Symptoms:

50 (show all 35)
  • restricted joint mobility/joint stiffness/ankylosis
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • lung fibrosis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • recurrent urinary infections
  • peripheral neuropathy
  • bone marrow failure/pancytopenia
  • thrombocytopenia/thrombopenia
  • lymphoma
  • early death/lethality
  • sepsis severe/septicemia
  • hepatomegaly/liver enlargement (excluding storage disease)
  • irregular/in bands/reticular skin hyperpigmentation
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • polynuclear cells/neutrophils anomalies/neutropenia
  • autoimmunity/autoimmune reaction/autoantibodies
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • joint/articular deformation
  • arthritis/synovitis/synovial proliferation
  • articular/joint pain/arthralgia
  • osteolysis/osteoclasia/bone destruction/erosions
  • repeat respiratory infections
  • chronic/relapsing otitis
  • pharyngitis
  • chronic skin infection/ulcerations/ulcers/cancrum
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • lymphocytes anomalies
  • anaemia
  • lymphadenopathy/polyadenopathies
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • splenomegaly
  • subcutaneous nodules/lipomas/tumefaction/swelling

Drugs & Therapeutics for Felty's Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Felty's Syndrome

Drug clinical trials:

Search ClinicalTrials for Felty's Syndrome

Search NIH Clinical Center for Felty's Syndrome

Search CenterWatch for Felty's Syndrome

Genetic Tests for Felty's Syndrome

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Anatomical Context for Felty's Syndrome

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Sources:
34MalaCards
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MalaCards organs/tissues related to Felty's Syndrome:

34
Skin, Liver, Spleen, Lymph node, Bone, Bone marrow, Lung, T cells, Myeloid, Endothelial, B cells

Animal Models for Felty's Syndrome or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Felty's Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6CSF2, IL10, IL3, EEF1A1
2MP:00053977.2CSF3, CSF2, IL8, IL10, IL3, EEF1A1
3MP:00053877.0EEF1A1, IL3, IL10, IL8, CSF2, CSF3

Publications for Felty's Syndrome

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Sources:
53PubMed
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Articles related to Felty's Syndrome:

(show top 50)    (show all 328)
idTitleAuthorsYear
1
Neutrophil activation and B-cell stimulation in the pathogenesis of Felty's syndrome. (22814518)
2012
2
Felty's syndrome as an initial presentation of rheumatoid arthritis: a case report. (19946450)
2009
3
Efficacy of rituximab in Felty's syndrome. (18697782)
2008
4
Felty's syndrome with chronic hepatitis and compatible autoimmune hepatitis: a case presentation. (15897648)
2005
5
Felty's syndrome. (15454123)
2004
6
Autoantibodies against granulocyte-macrophage colony stimulating factor and interleukin-3 are rare in patients with Felty's syndrome. (15194585)
2004
7
Autoantibodies against granulocyte colony-stimulating factor in Felty's syndrome and neutropenic systemic lupus erythematosus. (12355486)
2002
8
Neutrophil phagocytosis in Felty's syndrome. (11705439)
2001
9
Major histocompatility complex haplotypic associations in Felty's syndrome and large granular lymphocyte syndrome are secondary to allelic association with HLA-DRB1 *0401. (10817772)
2000
10
Pulmonary veno-occlusive disease complicating Felty's syndrome. (9893784)
1998
11
Treatment of Felty's syndrome with the haemopoietic growth factor granulocyte colony-stimulating factor (G-CSF). (9519212)
1998
12
Interleukin-10 promoter polymorphisms in rheumatoid arthritis and Felty's syndrome. (9783765)
1998
13
Prolonged treatment with granulocyte colony-stimulating factor in a patient with Felty's syndrome and chronic renal failure from secondary amyloidosis. (9269662)
1997
14
Successful treatment of agranulocytosis and sepsis with granulocyte colony stimulating factor in a case of Felty's syndrome. (8523369)
1995
15
Felty's syndrome treated with rhG-CSF associated with flare of arthritis and skin rash. (7540527)
1995
16
Indication for and caution in the use of granulocyte colony-stimulating factor for the treatment of Felty's syndrome: comment on the report by Yasuda et al. (7524509)
1994
17
Orbital lymphoma in a patient with Felty's syndrome. (1540565)
1992
18
DR-DQ variants in rheumatoid arthritis and Felty's syndrome: comment on the article by Wallin et al. (1622429)
1992
19
Digital vasculitis after splenectomy in a patient with Felty's syndrome. (1632669)
1992
20
Analysis of lymphocyte phenotype and T cell receptor genotype in Felty's syndrome. (1380988)
1992
21
Effect of corticosteroid treatment on hemopoiesis in vivo and in vitro in a patient with Felty's syndrome. (1786345)
1991
22
Ectopic splenomegaly in Felty's syndrome. (2032427)
1991
23
Worsening of Felty's syndrome with methotrexate. (1929594)
1991
24
Is there a place for splenectomy in the treatment of Felty's syndrome? (2306569)
1990
25
Resolution of Felty's syndrome with cyclophosphamide. (2754676)
1989
26
Felty's syndrome: a therapeutic dilemma? (2769662)
1989
27
Neutropenia and infections in Felty's syndrome. (3378123)
1988
28
Felty's syndrome in black Americans: a case report. (3594967)
1987
29
Simultaneous presentation of rheumatoid arthritis and acute myeloid leukaemia masquerading as Felty's syndrome. (3465419)
1986
30
Radiocolloid scintigraphy in Felty's syndrome. (3487213)
1986
31
Treatment of Felty's syndrome with low-dose oral methotrexate. (3741502)
1986
32
HLA-DR4 in Felty's syndrome. (3876440)
1985
33
Felty's syndrome in an Asian. (4016489)
1985
34
D-penicillamine in Felty's syndrome. (4057191)
1985
35
Felty's syndrome in a child. (6520839)
1984
36
Kingella kingae causing septic arthritis in Felty's syndrome. (6622347)
1983
37
High-dose immunoglobulin in Felty's syndrome. (6882047)
1983
38
HLA-DRw4 in Felty's syndrome. (6934775)
1980
39
Felty's syndrome: granulocyte-bound immunoglobulin G and splenectomy. (970768)
1976
40
Letter: Lithium in Felty's syndrome. (1259276)
1976
41
Familial Felty's syndrome. (984910)
1976
42
Spontaneous remission of Felty's syndrome. (1191353)
1975
43
Splenectomy and Felty's syndrome. (1146350)
1975
44
The mechanism of neutropenia in Felty's syndrome. (4416356)
1974
45
Symptomatic porphyria in a case of Felty's syndrome. I. Clinical and routine biochemcial studies. (5019121)
1972
46
Symptomatic porphyria in a case of Felty's syndrome. II. Biochemical investigations. (5019122)
1972
47
Leucocyte-specific anti-nuclear factors in patients with felty's syndrome, rheumatoid arthritis, systemic lupus erythematosus and other diseases. (5325973)
1966
48
Felty's syndrome; response to splenectomy after cortisone failure. (13227656)
1955
49
Neutropenia associated with splenomegaly and atrophic arthritis (Felty's syndrome); report of a case in which splenectomy was performed. (15411128)
1950
50
Primary splenic neutropenia with rheumatoid arthritis. (Felty's syndrome). (15427053)
1950

Variations for Felty's Syndrome

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Expression for genes affiliated with Felty's Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Felty's Syndrome

Search GEO for disease gene expression data for Felty's Syndrome.

Pathways for genes affiliated with Felty's Syndrome

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Sources:
51PathCards, 55R&D Systems, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 56Reactome
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Pathways related to Felty's Syndrome according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7IL10, CSF2
29.6C4A, IL10
39.6CSF2, IL8
49.6CSF2, IL8
59.3IL8, EEF1A1
6
Show member pathways
9.2C4A, IL10, IL3
79.2IL3, IL8, CSF2
8
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.2CSF2, IL8, IL3
99.2CSF2, IL8, IL10
10
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.2TRA, CSF2, IL10
119.1IL10, IL8, C4A
129.1C4A, IL8, IL10
139.1IL3, IL10, IL8
148.9CSF3, CSF2, IL3
15
Show member pathways
8.8CSF3, CSF2, IL8
168.7IL10, IL8, CSF3
17
Show member pathways
Type III interferon signaling39
8.4CSF3, CSF2, IL10, IL3
188.3TRA, CSF3, CSF2, IL10
19
Show member pathways
7.9IL3, IL10, IL8, CSF2, CSF3
20
Show member pathways
7.9IL3, IL10, IL8, CSF2, CSF3
21
Show member pathways
7.9IL3, IL10, IL8, CSF2, CSF3
22
Show member pathways
7.9IL3, IL10, IL8, CSF2, CSF3

Compounds for genes affiliated with Felty's Syndrome

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Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank, 30IUPHAR, 3BitterDB, 52PharmGKB, 25HMDB
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Compounds related to Felty's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1bmmp4610.0IL3, CSF2
2as 10146 6210.6IL10, IL3, CSF2
3azithromycin46 1210.5IL8, CSF2, IL10
4lenograstim469.5CSF3, IL3
5il-12469.5CSF2, IL10, IL8
6imiquimod46 62 30 1212.5CSF2, IL8, IL10
7groalpha469.5CSF2, IL8, IL10
8romurtide469.5CSF3, CSF2
9poly(i-c)469.5IL3, IL8, CSF2
10ivig469.4CSF2, IL10, IL3
11molgramostim469.3CSF3, CSF2, IL3
12pegfilgrastim46 1210.3IL3, CSF2, CSF3
13mesna469.3CSF2, CSF3, IL3
14quinine46 30 3 52 1213.3IL10, CSF2, IL3
15tarc469.3CSF2, IL8, IL10
16thiotepa46 52 1211.3IL3, CSF2, CSF3
17ara-ctp469.3CSF3, CSF2, IL3
18mafosfamide469.3CSF3, IL3, CSF2
194-hydroperoxycyclophosphamide469.3CSF3, CSF2, IL3
20pixy321469.3CSF2, IL3, CSF3
21amifostine46 1210.3IL3, CSF3, CSF2
22filgrastim46 1210.3CSF3, IL3, CSF2
23anaphylatoxin469.3CSF2, IL3, IL8, C4A
24idarubicin52 46 1211.3IL3, CSF3, CSF2
25ifosfamide46 1210.2CSF2, IL3, CSF3
26mip 1alpha469.2CSF2, IL8, IL10, IL3
27il 10469.2IL8, CSF2, IL3, IL10
28mitoxantrone46 52 1211.2IL3, CSF2, CSF3
29neopterin469.2CSF2, IL3, IL8, IL10
30methylcellulose469.1CSF2, IL3, CSF3
31hydrocortisone46 3 62 1212.1CSF2, IL10, IL3, IL8
32leucovorin46 52 1211.1CSF2, IL3, CSF3
33ionomycin469.1TRA, IL10, IL3, CSF2
34pentoxifylline46 1210.1CSF2, IL8, IL10
35mycophenolate mofetil46 52 1211.0IL3, IL10, CSF3
36melphalan46 52 1210.9CSF3, CSF2, IL3
37ribavirin46 52 1210.9IL3, IL10, CSF2, CSF3
38zidovudine46 52 1210.8IL10, CSF2, CSF3, IL3
39hydroxyurea46 52 1210.8IL10, IL3, CSF2, CSF3
40n-formylmethionyl-leucylphenylalanine468.8CSF2, CSF3, IL3, IL8
41cyclophosphamide46 52 1210.8CSF2, CSF3, IL3, IL10
42fmlp468.7CSF3, IL3, CSF2, IL8
43ccl346 309.7CSF3, IL8, IL10
44histamine46 30 2510.4IL3, IL10, IL8, CSF2
45endotoxin468.4CSF3, CSF2, C4A, IL10, IL8
46gm-csf46 309.4IL10, IL8, IL3, CSF2, CSF3
47rantes468.4IL10, IL8, CSF2, CSF3, IL3
48cyclosporin a46 30 6210.3IL10, IL8, CSF2, CSF3, IL3
49cycloheximide468.3IL8, IL10, IL3, CSF3, CSF2
50dexamethasone46 52 30 1211.2IL8, IL10, CSF3, IL3, CSF2

GO Terms for genes affiliated with Felty's Syndrome

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17Gene Ontology
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Cellular components related to Felty's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.8C4A, CSF2, IL8, IL3
2extracellular spaceGO:0056157.0CSF3, EEF1A1, IL3, IL10, IL8, CSF2

Biological processes related to Felty's Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8IL3, CSF2
2positive regulation of DNA replicationGO:0457409.6IL3, CSF2
3response to molecule of bacterial originGO:0022379.6IL8, IL10
4positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2CSF3, IL3
5inflammatory responseGO:0069549.1C4A, IL8, IL10
6positive regulation of cell proliferationGO:0082848.6CSF3, CSF2, IL3
7immune responseGO:0069558.5IL3, IL8, CSF2, CSF3
8cellular response to lipopolysaccharideGO:0712228.5CSF3, CSF2, IL8, IL10

Molecular functions related to Felty's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.4CSF3, CSF2, IL10, IL3
2growth factor activityGO:0080838.1CSF3, CSF2, IL10, IL3

Products for genes affiliated with Felty's Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Felty's Syndrome

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet