MCID: FLT001
MIFTS: 62

Felty's Syndrome malady

Bone diseases, Blood diseases, Genetic diseases categories

Summaries for Felty's Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Felty's syndrome is a rare, potentially serious disorder that is defined by the presence of three conditions: rheumatoid arthritis (ra), an enlarged spleen (splenomegaly) and a decreased white blood cell count (neutropenia), which causes repeated infections. although some individuals with felty's syndrome are asymptomatic, others can develop serious and life-threatening infections. symptoms of felty's syndrome, in addition to those associated with the three conditions stated above, may include fatigue, fever, weight loss, discoloration of patches of skin, mild hepatomegaly (enlarged liver), lymphadenopathy (swelling of lymph nodes), sjögren syndrome, vasculitis, lower-extremity ulcers, and other findings. the exact cause is unknown, but several risk factors have been proposed, including autoimmunity. a few familial cases of the condition have been reported. treatment typically focuses on controlling the underlying ra; immunosuppressive therapy for ra may improve neutropenia and splenomegaly. last updated: 1/6/2011

MalaCards: Felty's Syndrome, also known as felty syndrome, is related to arthritis and leukemia, and has symptoms including restricted joint mobility/joint stiffness/ankylosis, abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax and lung fibrosis. An important gene associated with Felty's Syndrome is C4A (complement component 4A (Rodgers blood group)), and among its related pathways are Rho Family GTPases and Cytokines and Inflammatory Response. The compounds gm-csf and hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spleen, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A syndrome that results in rheumatoid arthritis, splenomegaly and neutropenia.

Wikipedia:63 Felty\'s syndrome, also called Felty syndrome, is characterized by the combination of rheumatoid... more...

Description from OMIM:46 134750

Aliases & Classifications for Felty's Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 48Orphanet, 46OMIM, 10DISEASES, 44Novoseek, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Bone diseases, Blood diseases


Characteristics (Orphanet epidemiological data):

48
felty syndrome:
Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

felty's syndrome 8 42 60
felty syndrome 42 48 46
familial felty's syndrome 42 60
feltys syndrome 10 44
rheumatoid arthritis with splenoadenomegaly and leukopenia 8
splenomegaly-neutropenia-rheumatoid arthritis syndrome 48
rheumatoid arthritis, splenomegaly and neutropenia 42


External Ids:

Disease Ontology8 DOID:11042
NCIt39 C84712
ICD9CM27 714.1
MeSH34 D005258
OMIM46 134750
SNOMED-CT56 156482001, 57160007
MESH via Orphanet35 D005258
ICD10 via Orphanet26 M05.0
SNOMED-CT via Orphanet57 57160007
UMLS via Orphanet61 C0015773
ICD1025 M05.0

Related Diseases for Felty's Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Felty's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.2IL8, IL10, CSF2
2leukemia30.1CSF2, CSF3, TRA, IL3, B3GAT1, EEF1A1
3rheumatoid arthritis30.1CSF2, TRA, IL10, IL8, B3GAT1
4neutropenia29.9CSF2, CSF3, IL3, B3GAT1
5juvenile rheumatoid arthritis10.1
6natural killer cell leukemia10.0
7adult syndrome10.0
8histoplasmosis10.0
9hepatitis10.0EEF1A1
10capillary leak syndrome10.0CSF2
11prostate cancer10.0EEF1A1
12lupus erythematosus10.0C4A
13multiple myeloma10.0CSF3
14hypereosinophilic syndrome10.0CSF2
15glycogen storage disease10.0CSF3
16dermatitis10.0CSF2
17severe combined immunodeficiency10.0IL3
18sarcoma10.0B3GAT1
19human immunodeficiency virus infectious disease10.0B3GAT1
20astrocytoma10.0B3GAT1
21kidney cancer10.0CSF2
22polycythemia vera10.0IL3
23polycythemia10.0IL3
24periodontitis10.0IL8
25bronchiolitis10.0IL8
26rhinitis10.0IL8
27pulmonary fibrosis10.0IL8
28pulmonary eosinophilia10.0IL8
29cystic fibrosis10.0IL8
30gastritis10.0IL8
31chorioamnionitis10.0IL8
32meningitis10.0IL8
33stomatitis10.0CSF2, CSF3
34endometriosis10.0IL8
35malaria10.0IL10
36lung cancer10.0CSF3, CSF2
37hypersensitivity reaction type ii disease10.0IL10
38pulmonary alveolar proteinosis10.0CSF2, IL3
39hepatitis c10.0IL10
40atopy10.0IL10
41myelofibrosis10.0IL3, CSF3
42galactosemia10.0IL10
43common variable immune deficiency10.0IL10
44chronic myelomonocytic leukemia10.0CSF3, CSF2
45pancreatic cancer10.0IL8
46germ cell cancer10.0B3GAT1
47megakaryocytic leukemia10.0IL3, CSF2
48tuberculosis10.0EEF1A1, IL10
49monocytic leukemia10.0IL8, CSF2
50factor vii deficiency10.0CSF3, CSF2

Graphical network of the top 20 diseases related to Felty's Syndrome:



Diseases related to felty's syndrome

Clinical Features for Felty's Syndrome

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46OMIM, 48Orphanet
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Clinical features from OMIM:

134750

Clinical synopsis from OMIM:

134750

Symptoms:

48 (show all 35)
  • restricted joint mobility/joint stiffness/ankylosis
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • lung fibrosis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • recurrent urinary infections
  • peripheral neuropathy
  • bone marrow failure/pancytopenia
  • thrombocytopenia/thrombopenia
  • lymphoma
  • early death/lethality
  • sepsis severe/septicemia
  • hepatomegaly/liver enlargement (excluding storage disease)
  • irregular/in bands/reticular skin hyperpigmentation
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • polynuclear cells/neutrophils anomalies/neutropenia
  • autoimmunity/autoimmune reaction/autoantibodies
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • joint/articular deformation
  • arthritis/synovitis/synovial proliferation
  • articular/joint pain/arthralgia
  • osteolysis/osteoclasia/bone destruction/erosions
  • repeat respiratory infections
  • chronic/relapsing otitis
  • pharyngitis
  • chronic skin infection/ulcerations/ulcers/cancrum
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • lymphocytes anomalies
  • anaemia
  • lymphadenopathy/polyadenopathies
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • splenomegaly
  • subcutaneous nodules/lipomas/tumefaction/swelling

Drugs & Therapeutics for Felty's Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Felty's Syndrome

Drug clinical trials:

Search ClinicalTrials for Felty's Syndrome

Search NIH Clinical Center for Felty's Syndrome

Search CenterWatch for Felty's Syndrome

Genetic Tests for Felty's Syndrome

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Anatomical Context for Felty's Syndrome

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Sources:
32MalaCards
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MalaCards organs/tissues related to Felty's Syndrome:

32
Skin, Liver, Spleen, Lymph node, Bone, Bone marrow, Lung, T cells, Myeloid, Endothelial, B cells

Animal Models for Felty's Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Felty's Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.3CSF3, IL3, IL10, IL8, EEF1A1, CSF2
2MP:00053977.0EEF1A1, IL8, IL10, IL3, CSF3, CSF2

Publications for Felty's Syndrome

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Sources:
50PubMed
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Articles related to Felty's Syndrome:

(show top 50)    (show all 334)
idTitleAuthorsYear
1
Neutrophil activation and B-cell stimulation in the pathogenesis of Felty's syndrome. (22814518)
2012
2
Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps. (22034172)
2012
3
Felty's syndrome. (15454123)
2004
4
Salazosulfapyridine-induced remission of Felty's syndrome along with significant reduction in neutrophil-bound immunoglobulin G. (12563703)
2003
5
No serological evidence to implicate a role for cytomegalovirus infection in the aetiology of Felty's syndrome. (9851287)
1998
6
Methotrexate treatment in Felty's syndrome. (9734684)
1998
7
Prolonged treatment with granulocyte colony-stimulating factor in a patient with Felty's syndrome and chronic renal failure from secondary amyloidosis. (9269662)
1997
8
Flare of arthritis with successful treatment of Felty's syndrome with granulocyte colony stimulating factor (GCSF). (7540528)
1995
9
Granulocyte colony-stimulating factor induction of improved leukocytopenia with inflammatory flare in a Felty's syndrome patient. (7510482)
1994
10
Primary T cell lymphoma of the liver in a patient with Felty's syndrome. (8162482)
1994
11
Digital vasculitis after splenectomy in a patient with Felty's syndrome. (1632669)
1992
12
Methotrexate treatment of Felty's syndrome. (2322031)
1990
13
Sinusoidal lymphocytosis of the liver in Felty's syndrome with a review of the liver involvement in Felty's syndrome. (2646362)
1989
14
Small cell lung cancer in a patient with neutropenia due to Felty's syndrome. (2554513)
1989
15
The spleen in Felty's syndrome: a histological, morphometrical, and immunohistochemical study. (3277856)
1988
16
Nodular regenerative hyperplasia of the liver and esophageal varices in Felty's syndrome: a clinicopathologic case report with review of the literature. (3284264)
1988
17
Suppression of superoxide generation by normal polymorphonuclear leukocytes preincubated in plasma from patients with Felty's syndrome. (3037685)
1987
18
Felty's syndrome responding to chrysotherapy. (3118022)
1987
19
Spontaneous pyomyositis in a patient with Felty's syndrome: diagnosis using computerized tomography. (3738584)
1986
20
HLA-DR4 in Felty's syndrome. (3876440)
1985
21
Felty's syndrome in an Asian. (4016489)
1985
22
Phagocytosis and intracellular killing by polymorphonuclear cells from patients with rheumatoid arthritis and Felty's syndrome. (3986006)
1985
23
Felty's syndrome associated with high levels of IgA rheumatoid factor. (6742912)
1984
24
Kingella kingae causing septic arthritis in Felty's syndrome. (6622347)
1983
25
Granulocyte colony formation and a short term isotopic assay of myeloid precursors in Felty's syndrome. (6653067)
1983
26
Felty's syndrome: report of a case and review of the literature. (6643150)
1983
27
Felty's syndrome: response to parenteral gold. (7328565)
1981
28
Inhibition of human bone marrow-granulocyte precursors by serum from patients with Felty's syndrome. (7190612)
1980
29
Portal hypertension in Felty's syndrome. (7416125)
1980
30
Gastric volvulus and Felty's syndrome. (7362678)
1980
31
Comparison of the presence of immune complexes in Felty's syndrome and rheumatoid arthritis. (417729)
1978
32
Presence of leucocyte inclusions in spleen and bone marrow of patients with Felty's syndrome. (205650)
1978
33
Felty's syndrome: granulocyte-bound immunoglobulin G and splenectomy. (970768)
1976
34
Corticosteroid therapy in Felty's syndrome and its effect on hypersplenic rats. (4843739)
1974
35
Recurrent Felty's syndrome associated with splenosis and probable splenic regeneration. (4424016)
1974
36
White-cell antibodies and the aetiology of Felty's syndrome. (4546979)
1974
37
Remission of Felty's syndrome with long-term testosterone therapy. (4739194)
1973
38
Cirrhosis of the liver in Felty's syndrome. (4753065)
1973
39
Refractory skin ulcers in Felty's syndrome. Healing following splenectomy. (5256989)
1969
40
Leucocyte-specific anti-nuclear factors in patients with felty's syndrome, rheumatoid arthritis, systemic lupus erythematosus and other diseases. (5325973)
1966
41
Listeria as a cause of splenic granulomas in a patient with Felty's syndrome. (13852880)
1960
42
The spontaneous rupture of the spleen in Felty's syndrome. (13504497)
1958
43
Felty's syndrome; response to splenectomy after cortisone failure. (13227656)
1955
44
The bone-marrow in Felty's syndrome. (13273832)
1955
45
Felty's syndrome; report of a case. (13151968)
1954
46
Two cases of Felty's syndrome with features of SjAPgren's syndrome. (14941824)
1952
47
Felty's syndrome treated with ACTH. (14877458)
1951
48
Primary splenic neutropenia with rheumatoid arthritis. (Felty's syndrome). (15427053)
1950
49
Felty's syndrome: clinical and therapeutic remarks. (14787136)
1950
50
Dysphagia in Felty's syndrome. (15403073)
1950

Genetic Variations for Felty's Syndrome

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Expression for genes affiliated with Felty's Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Felty's Syndrome

Search GEO for disease gene expression data for Felty's Syndrome.

Pathways for genes affiliated with Felty's Syndrome

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51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG
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Pathways related to Felty's Syndrome according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1CSF2
210.0TRA
39.7IL8, CSF2
4
Hide members
9.6IL10, CSF2
5
Hide members
9.3CSF2, IL3, IL8
69.3IL8, IL3, CSF2
79.2IL8, IL10, C4A
89.2C4A, IL10, IL8
99.2IL8, IL10, CSF2
109.1IL3, IL10, IL8
11
Hide members
9.1CSF2, TRA, IL10
128.9CSF2, CSF3, IL3
13
Cytokine production by Th17 cells in CF (Mouse model)
8.9CSF2, CSF3, IL8
148.4IL10, IL3, CSF3, CSF2
15
Hide members
8.0CSF2, CSF3, IL3, IL10, IL8
16
Hide members
8.0CSF2, CSF3, IL3, IL10, IL8
17
Hide members
8.0CSF2, CSF3, IL3, IL10, IL8

Compounds for genes affiliated with Felty's Syndrome

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Sources:
44Novoseek, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Felty's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.4IL10
2hydrocortisone44 2 59 1113.4IL8
3bmmp4410.1IL3, CSF2
4endotoxin449.8C4A, CSF3
5as 10159 4410.6CSF2, IL10, IL3
6lenograstim449.6IL3, CSF3
7romurtide449.6CSF3, CSF2
8poly(i-c)449.6CSF2, IL8, IL3
9azithromycin44 1110.5IL8, IL10, CSF2
10il-12449.5IL10, CSF2, IL8
11imiquimod44 28 59 1112.5CSF2, IL10, IL8
12groalpha449.5IL8, IL10, CSF2
13daniplestim449.4IL3, CSF3
14anaphylatoxin449.4IL3, CSF2, C4A, IL8
15molgramostim449.4IL3, CSF3, CSF2
16pegfilgrastim44 1110.4CSF2, CSF3, IL3
17mesna449.4IL3, CSF2, CSF3
18thiotepa44 49 1111.4CSF3, CSF2, IL3
19ara-ctp449.4CSF2, CSF3, IL3
20mafosfamide449.4CSF3, IL3, CSF2
21rantes449.4IL3, CSF3, CSF2
22ivig449.3CSF2, IL10, IL3
234-hydroperoxycyclophosphamide449.3CSF3, CSF2, IL3
24pixy321449.3IL3, CSF3, CSF2
25amifostine44 1110.3CSF2, IL3, CSF3
26tarc449.3IL10, IL8, CSF2
27idarubicin44 49 1111.3CSF3, CSF2, IL3
28filgrastim44 1110.3CSF2, CSF3, IL3
29quinine44 28 2 1112.3IL10, CSF2, IL3
30mip 1alpha449.2IL3, IL8, CSF2, IL10
31ifosfamide44 1110.2CSF3, IL3, CSF2
32leucovorin44 49 1111.2IL3, CSF2, CSF3
33il 10449.2IL3, IL8, IL10, CSF2
34neopterin449.2IL3, IL8, CSF2, IL10
35mitoxantrone44 49 1111.2CSF3, CSF2, IL3
36methylcellulose449.1CSF2, CSF3, IL3
37pentoxifylline44 1110.1IL10, CSF2, IL8
38ionomycin449.0CSF2, IL3, TRA, IL10
39mycophenolate mofetil44 49 1111.0IL10, IL3, CSF3
40melphalan44 119.9CSF3, CSF2, IL3
41n-formylmethionyl-leucylphenylalanine448.9IL8, CSF2, CSF3, IL3
42ribavirin44 49 1110.8CSF2, CSF3, IL10, IL3
43zidovudine44 119.8IL10, IL3, CSF3, CSF2
44fmlp448.8IL8, CSF2, CSF3, IL3
45hydroxyurea44 49 1110.8CSF2, CSF3, IL3, IL10
46histamine44 28 2410.8CSF2, IL3, B3GAT1, IL8, IL10
47cyclophosphamide44 49 1110.8IL10, CSF3, CSF2, IL3
48ccl344 289.7IL8, IL10, CSF3
49cyclosporin a44 28 5910.3CSF2, IL10, IL8, CSF3, IL3
50dexamethasone44 49 28 1110.7IL10, IL3, IL8, CSF3, CSF2

GO Terms for genes affiliated with Felty's Syndrome

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16Gene Ontology
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Cellular components related to Felty's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.6IL8, IL10, IL3, C4A, CSF3, CSF2

Biological processes related to Felty's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of DNA replicationGO:0457409.8IL3, CSF2
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.5IL3, CSF2
3response to molecule of bacterial originGO:0022379.4IL8, IL10
4immune responseGO:0069558.5CSF2, CSF3, IL3, IL8
5cellular response to lipopolysaccharideGO:0712228.4IL8, IL10, CSF3, CSF2

Molecular functions related to Felty's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.4IL10, IL3, CSF3, CSF2
2growth factor activityGO:0080838.1IL10, IL3, CSF3, CSF2

Products for genes affiliated with Felty's Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Felty's Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet