MCID: FML027
MIFTS: 50

Female Breast Carcinoma malady

Cancer diseases category

Summaries for Female Breast Carcinoma

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A breast carcinoma that is manifested in the female breast.

MalaCards: Female Breast Carcinoma, also known as mammary carcinoma of female breast, is related to breast cancer and male breast cancer. An important gene associated with Female Breast Carcinoma is CHGB (chromogranin B (secretogranin 1)), and among its related pathways are Doxorubicin Pathway, Pharmacokinetics and Ovarian Infertility Genes. The compounds megestrol acetate and estracyt have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Female Breast Carcinoma

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

female breast carcinoma 9 11 63
mammary carcinoma of female breast 9
female breast cancer 9


External Ids:

Disease Ontology9 DOID:7843, DOID:0050671
NCIt41 C2918

Related Diseases for Female Breast Carcinoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Female Breast Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.3BRCA1, PGR, ESR1, ERBB2, CDK4
2male breast cancer30.8ERBB2, ESR1, PGR, BRCA1
3melanoma29.8MLH1, BLZF1, TP53, ENO2, CDKN2A, CDK4
4turcot syndrome10.1MLH1
5somatostatinoma10.1CHGA
6cerebral meningioma10.1PGR
7cerebral primitive neuroectodermal tumor10.1ENO2
8fallopian tube cancer10.1BRCA1
9subependymal giant cell astrocytoma10.1ENO2
10cystadenoma10.1BRCA1
11actinic keratosis10.1TP53
12endocrine gland cancer10.1MLH1, CHGA
13biliary tract neoplasm10.1MLH1, ERBB2
14breast carcinoma in situ10.1
15prostatitis10.1
16alveolar soft part sarcoma10.1ENO2, MLH1
17gliosarcoma10.1CDK4
18pineocytoma10.1CHGA, ENO2
19lynch syndrome10.1MLH1, BRCA1
20parathyroid adenoma10.1CHGB, CHGA
21merkel cell carcinoma10.1ENO2, CHGA
22sertoli cell tumor10.1PGR, ENO2
23ganglioglioma10.1CHGA, ENO2
24glucagonoma10.1CHGB, CHGA, ENO2
25paraganglioma10.1ENO2, CHGA, CHGB
26thyroid medullary carcinoma10.1CHGB, CHGA, ENO2
27neuroblastoma10.1TP53, ENO2
28alveolar rhabdomyosarcoma10.1ENO2, CDK4
29neuroendocrine tumor10.1CHGB, CHGA, ENO2
30neurofibromatosis10.1MLH1, BLZF1, ENO2
31meningioma10.1PGR, ESR1
32cribriform carcinoma10.1PGR, ESR1
33carcinoid syndrome10.1CHGB, CHGA, ENO2
34progesterone resistance10.1PGR, ESR1
35malignant mixed mullerian tumor10.1PGR, ESR1
36gastrinoma10.1CHGA, ENO2
37leiomyomatosis10.1PGR, ESR1
38adenosarcoma10.1PGR, ESR1
39gallbladder cancer10.1TP53, MLH1
40myoma10.1PGR, ESR1
41pituitary adenoma10.1CHGB, CHGA, CDK4
42endometrial stromal sarcoma10.1PGR, ESR1
43fanconi's anemia10.1MLH1, BLZF1, BRCA1
44uterine fibroid10.1PGR, ESR1
45stomach cancer10.1TP53, ERBB2
46prolactinoma10.1ESR1, CHGB, CHGA
47lymphangioleiomyomatosis10.1ESR1, PGR
48angiomyolipoma10.1PGR, ESR1
49ganglioneuroblastoma10.1ENO2, CD44
50pituitary tumors10.0ESR1, CHGB, CHGA

Graphical network of the top 20 diseases related to Female Breast Carcinoma:



Diseases related to female breast carcinoma

Symptoms for Female Breast Carcinoma

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Drugs & Therapeutics for Female Breast Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Female Breast Carcinoma

Drug clinical trials:

Search ClinicalTrials for Female Breast Carcinoma

Search NIH Clinical Center for Female Breast Carcinoma

Search CenterWatch for Female Breast Carcinoma

Genetic Tests for Female Breast Carcinoma

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Anatomical Context for Female Breast Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Female Breast Carcinoma:

34
Breast, Lymph node, Prostate

Animal Models for Female Breast Carcinoma or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Female Breast Carcinoma:

38 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4CD44, CDK4, CDKN2A, ESR1, TP53
2MP:00053678.4TP53, BRCA1, ESR1, CHGA, CDK4, CD44
3MP:00053808.1TP53, BRCA1, PGR, ESR1, ERBB2, CDKN2A
4MP:00053817.9MLH1, TP53, BRCA1, ESR1, ERBB2, CDKN2A
5MP:00053697.8TP53, BRCA1, PGR, ESR1, ERBB2, CDKN2A
6MP:00053887.8TP53, BRCA1, ESR1, ERBB2, ENO2, CDKN2A
7MP:00053717.7BLZF1, TP53, BRCA1, PGR, ESR1, ERBB2
8MP:00053977.7TP53, BRCA1, PGR, ESR1, CDKN2A, CDK4
9MP:00020067.6MLH1, TP53, BRCA1, PGR, ESR1, ERBB2
10MP:00107717.6MLH1, TP53, BRCA1, PGR, ESR1, ERBB2
11MP:00053787.6TP53, BRCA1, ESR1, CHGA, ERBB2, CDKN2A
12MP:00053877.5TP53, BRCA1, PGR, ESR1, CDKN2A, CDK4
13MP:00053857.4TP53, BRCA1, PGR, ESR1, CHGA, VASH1
14MP:00053897.4MLH1, TP53, BRCA1, PGR, ESR1, CHGA
15MP:00053907.3BLZF1, TP53, BRCA1, PGR, ESR1, ERBB2
16MP:00036317.2TP53, BRCA1, ESR1, CHGB, ERBB2, ENO2
17MP:00053867.2TP53, BRCA1, PGR, ESR1, ERBB2, ENO2
18MP:00107687.2MLH1, TP53, BRCA1, PGR, ESR1, CHGA
19MP:00053797.2CD44, MLH1, TP53, BRCA1, PGR, ESR1
20MP:00053767.1MLH1, TP53, BRCA1, PGR, ESR1, CHGB
21MP:00053847.1MLH1, TP53, BRCA1, PGR, ESR1, ERBB2

Publications for Female Breast Carcinoma

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Sources:
53PubMed
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Articles related to Female Breast Carcinoma:

(show all 28)
idTitleAuthorsYear
1
Risk factors of female breast carcinoma: a case control study at Puducherry. (23713049)
2013
2
Intratumoral estrogen concentration and expression of estrogen-induced genes in male breast carcinoma: comparison with female breast carcinoma. (23096432)
2013
3
Prevalence of known prognostic factors in female breast carcinoma including oestrogen receptor, progesterone receptor and Her-2/neu status--a study in a tertiary care centre. (23936949)
2012
4
Prostate-specific antigen and hormone receptor expression in male and female breast carcinoma. (20863373)
2010
5
Age related association of Her-2/neu with prognostic markers in female breast carcinoma. (20810050)
2010
6
Inter- and intra-ethnic differences for female breast carcinoma incidence in the continental United States and in the state of Hawaii. (16322891)
2006
7
Correlation of her-2/neu gene amplification with other prognostic and predictive factors in female breast carcinoma. (15982396)
2005
8
The role of CD44v3 expression in female breast carcinomas. (14998292)
2003
9
Status of HER-2 in male and female breast carcinoma. (11720677)
2001
10
Female breast carcinomas: nuclear and cytoplasmic proteins versus steroid receptors. (10756981)
2000
11
Germline BRCA1 and HMLH1 mutations in a family with male and female breast carcinoma. (10709098)
2000
12
Low-stage carcinoma of the male breast. A histologic, immunohistochemical, and flow cytometric comparison with localized female breast carcinoma. (9894455)
1999
13
Time trend of female breast carcinoma in situ by race and histology in Connecticut, USA. (9071907)
1997
14
Allium vegetable consumption, garlic supplement intake, and female breast carcinoma incidence. (7749142)
1995
15
Analysis of MTS1/CDK4 in female breast carcinomas. (7889533)
1995
16
Argyrophilia and granin (chromogranin/secretogranin) expression in female breast carcinomas. Their relationship to survival and other disease parameters. (1376022)
1992
17
Expression of tumour markers CA50, CEA and TPA in female breast carcinoma as related to histopathological findings and survival. (1567186)
1992
18
Hormone receptor status and mitotic activity as risk factors for recurrence and death in female breast carcinoma. (1768039)
1991
19
Regional lymph node reactions related to hormone receptor status in female breast carcinoma. (4004508)
1985
20
Hormone receptor levels related to histological parameters of tumor-host relationships in female breast carcinoma. (6287111)
1982
21
Histochemically demonstrable enzyme activities and their independence of the hormone receptor content in female breast carcinoma. (6298092)
1982
22
Paracortical activity in the lymph nodes draining female breast carcinoma. (311901)
1979
23
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. V. PHENOL,4,4'-(DL-1,2-DIETHYL-ETHYLENE)DI- AND ANDROST-4-EN-3-ONE, 9-CHLORO-11-BETA, 17-BETA-DIHYDROXY-17-METHYL-. (14278041)
1965
24
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. IV. 17-BETA-AMINO-5-ALPHA-ANDROSTAN-11-BETA-OL. (14176991)
1964
25
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. III. ANDROST-4-EN-3-ONE-2ALPHA,17BETA-DIHYDROXY DIPROPIONATE AND ANDROST-4-EN-3-ONE-16ALPHA, 17BETA-DIHYDROXY DIPROPIONATE. (14050008)
1963
26
Hormonal therapy of metastatic female breast carcinoma. II. 2alpha-Methyl dihydrotestosterone propionate. (13706491)
1961
27
The present controversy in the treatment of female breast carcinoma. (13665202)
1959
28
Hormonal therapy of metastatic female breast carcinoma. I. 9 alpha-Bromo-11-ketoprogesterone. (13663018)
1959

Variations for Female Breast Carcinoma

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Expression for genes affiliated with Female Breast Carcinoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Female Breast Carcinoma

Search GEO for disease gene expression data for Female Breast Carcinoma.

Pathways for genes affiliated with Female Breast Carcinoma

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Sources:
51PathCards, 52PharmGKB, 39NCBI BioSystems Database, 61Thomson Reuters, 54QIAGEN, 13EMD Millipore, 56Reactome, 31KEGG, 55R&D Systems, 58SinoBiological, 5Cell Signaling Technology
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Pathways related to Female Breast Carcinoma according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7MLH1, TP53
29.7CDK4, PGR, MLH1
39.6TP53, BRCA1
49.6BRCA1, TP53
59.6BRCA1, TP53
69.6BRCA1, TP53
7
Show member pathways
9.6CDK4, BRCA1, MLH1
8
Show member pathways
9.6CDK4, BRCA1, MLH1
9
Show member pathways
Cell cycle ESR1 regulation of G1 S transition61
Immune response MIF JAB1 signaling61
Cell cycle Cell cycle generic schema 61
9.5PGR, CDK4, ESR1
10
Show member pathways
9.5TP53, CDKN2A
119.5TP53, CDKN2A
12
Show member pathways
Signal transduction PTEN pathway61
9.4ERBB2, TP53, MLH1
13
Show member pathways
FOXA transcription factor networks39
9.4ESR1, BRCA1, KLK3
14
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation61
9.4CDKN2A, CDK4, BRCA1
159.4BRCA1, MLH1, TP53
169.4CDK4, TP53, ERBB2
179.3BRCA1, TP53, CDK4
18
Show member pathways
9.3CDK4, BRCA1, TP53
199.3BRCA1, TP53, CDK4
20
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.3ERBB2, TP53, ESR1
21
Show member pathways
9.2CDK4, CDKN2A, TP53
22
Show member pathways
Cell cycle39
9.2CDK4, TP53, CDKN2A
239.2CDKN2A, TP53, CDK4
24
Show member pathways
9.2CDKN2A, CDK4, TP53
259.2CDK4, CDKN2A, TP53
269.2TP53, CDKN2A, CDK4
279.2CDK4, TP53, CDKN2A
289.1CD44, TP53, CDKN2A
29
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.0TP53, CDK4, BRCA1, KLK3
309.0TP53, CDK4, ESR1, BRCA1
31
Show member pathways
9.0TP53, BRCA1, ESR1, CDK4
32
Show member pathways
8.9ERBB2, CDKN2A, CDK4, TP53
338.9ERBB2, ESR1, TP53, CD44
34
Show member pathways
DNA damage response39
8.9CDK4, CDKN2A, BRCA1, TP53
358.9TP53, ESR1, CDK4, CD44
36
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
8.8CD44, ERBB2, CDKN2A, TP53
378.7ESR1, BRCA1, TP53, CDK4, ERBB2
38
Show member pathways
8.6CDKN2A, CDK4, BRCA1, TP53, MLH1
398.5TP53, ERBB2, CDKN2A, CD44, BRCA1
408.3CDK4, CDKN2A, KLK3, TP53, ERBB2, MLH1
41
Show member pathways
Signaling Pathways in Glioblastoma39
8.3CDK4, TP53, BRCA1, ERBB2, KLK3, CDKN2A
42
Show member pathways
8.2ERBB2, TP53, CDK4, BRCA1, CDKN2A, ESR1
43
Show member pathways
8.2TP53, BRCA1, ESR1, CDKN2A, ERBB2, CDK4
44
Show member pathways
8.1TP53, CDK4, BLZF1, BRCA1, CDKN2A

Compounds for genes affiliated with Female Breast Carcinoma

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Sources:
46Novoseek, 25HMDB, 62Tocris Bioscience, 12DrugBank, 52PharmGKB, 30IUPHAR, 3BitterDB
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Compounds related to Female Breast Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 215)
idCompoundScoreTop Affiliating Genes
1megestrol acetate469.5PGR, ERBB2, KLK3, ESR1
2estracyt469.5CHGA, ENO2, KLK3
35-methylcytosine46 2510.2MLH1, CDKN2A, BRCA1, TP53
4p002469.2CHGA, BRCA1, MLH1, ERBB2, CD44
5flutamide46 62 1211.1PGR, ENO2, KLK3, ESR1, CHGA
6taxane469.1ERBB2, KLK3, ESR1, PGR, TP53
7geldanamycin46 52 62 1212.0PGR, ESR1, TP53, CDK4, ERBB2
8biotin46 25 1211.0CD44, CDKN2A, KLK3, MLH1, ERBB2
9indole-3-carbinol469.0KLK3, ESR1, BRCA1, CDK4, TP53
10folate468.9BRCA1, PGR, CDKN2A, ERBB2, MLH1
11bromodeoxyuridine468.9CHGA, MLH1, CDK4, ENO2, CD44
12gnrh468.9PGR, CHGA, ERBB2, CD44, ESR1, KLK3
13resveratrol46 62 25 1211.8BRCA1, PGR, ESR1, ERBB2, CDK4, TP53
14thymidylate468.8CDKN2A, CDK4, ERBB2, BRCA1, TP53, MLH1
15vitamin d468.7KLK3, CD44, CHGA, ESR1, CDK4, ERBB2
16camptothecin46 62 1210.7CDKN2A, BRCA1, CDK4, KLK3, MLH1, TP53
17diethylstilbestrol46 30 1210.7PGR, KLK3, ENO2, ESR1
185-aza-2deoxycytidine468.6MLH1, BRCA1, CDKN2A, ESR1, TP53, PGR
19vincristine46 52 1210.6CDKN2A, TP53, BRCA1, KLK3, CD44
20adriamycin468.6CD44, ERBB2, BRCA1, TP53, CDKN2A, PGR
21guanine46 25 1210.6TP53, CHGA, ERBB2, KLK3, ENO2, BRCA1
22methotrexate52 46 1210.6PGR, ENO2, CDKN2A, ERBB2, ESR1, BRCA1
23cyclophosphamide46 52 1210.5PGR, ERBB2, ESR1, CHGA, BRCA1, TP53
24tamoxifen46 52 30 1211.4PGR, BRCA1, TP53, ESR1, CHGA, CD44
25formaldehyde46 259.2ENO2, KLK3, ERBB2, CD44, CHGA, BLZF1
265fluorouracil468.1MLH1, CDK4, PGR, CDKN2A, ERBB2, TP53
27agarose468.1CDKN2A, MLH1, BLZF1, CD44, BRCA1
28mg 13246 629.0BRCA1, ESR1, CDKN2A, BLZF1, TP53
29etoposide46 52 62 1211.0CD44, MLH1, TP53, BRCA1, KLK3, ERBB2
30genistein46 30 62 3 25 1213.0PGR, CDK4, BLZF1, CDKN2A, BRCA1, ESR1
31butyrate467.9BLZF1, TP53, KLK3, CDKN2A, CDK4, CD44
32dexamethasone46 52 30 1210.8CD44, CDK4, CDKN2A, ENO2, KLK3, CHGA
33docetaxel46 52 62 1210.8ERBB2, CDKN2A, PGR, BRCA1, TP53, ENO2
34carboplatin46 52 129.7CDK4, CD44, ENO2, KLK3, ERBB2, MLH1
35arginine467.5CDKN2A, CHGA, ERBB2, MLH1, CD44, TP53
36doxorubicin46 52 129.4CDK4, CDKN2A, KLK3, ERBB2, ESR1, PGR
37oxygen46 258.4CDKN2A, CD44, CDK4, ENO2, CHGA, MLH1
38alanine467.2ENO2, CDKN2A, PGR, CDK4, CD44, MLH1
39paclitaxel46 52 129.1MLH1, TP53, BRCA1, PGR, ESR1, CHGA
40tyrosine467.1ENO2, ERBB2, BRCA1, BLZF1, CHGA, MLH1
41serine466.9CD44, CHGB, CHGA, BRCA1, ERBB2, KLK3
42steroid466.8CD44, CDK4, CDKN2A, KLK3, ERBB2, CHGA
43paraffin466.6KLK3, CHGA, ESR1, PGR, BRCA1, TP53
44cycloheximide466.6KLK3, CDKN2A, CDK4, ERBB2, CHGA, ESR1
45testosterone46 62 25 129.5CDK4, BRCA1, PGR, CDKN2A, ESR1, CHGA
46cisplatin46 52 62 129.4CHGA, ERBB2, ENO2, CDKN2A, CDK4, CD44
47retinoic acid46 257.4CHGA, MLH1, CDKN2A, CDK4, CD44, ENO2
48progesterone46 30 62 25 1210.1CD44, CDK4, CDKN2A, ENO2, ERBB2, CHGA
49vegf466.0CD44, CDK4, CDKN2A, ENO2, KLK3, ERBB2
50estrogen465.6CD44, CDK4, CDKN2A, ENO2, KLK3, ERBB2

GO Terms for genes affiliated with Female Breast Carcinoma

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Sources:
17Gene Ontology
See all sources

Cellular components related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.5CDKN2A, TP53
2nucleoplasmGO:0056547.9CDK4, CDKN2A, ESR1, PGR, BRCA1, TP53

Biological processes related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of immature T cell proliferation in thymusGO:0330889.8CDKN2A, ERBB2
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.5TP53, BRCA1
3replicative senescenceGO:0903999.5CDKN2A, TP53
4positive regulation of cell cycle arrestGO:0711589.3CDKN2A, BRCA1, TP53
5regulation of apoptotic processGO:0429819.3ESR1, BRCA1, TP53
6cell cycle arrestGO:0070508.6CDKN2A, VASH1, TP53

Molecular functions related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.8ESR1, PGR
2MDM2/MDM4 family protein bindingGO:0973719.4TP53, CDKN2A
3ubiquitin protein ligase bindingGO:0316258.5BRCA1, TP53, BLZF1
4enzyme bindingGO:0198998.2ESR1, PGR, BRCA1, TP53, BLZF1
5protein bindingGO:0055156.7PGR, BRCA1, TP53, MLH1, ESR1, CHGB

Products for genes affiliated with Female Breast Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Female Breast Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet