MCID: FML027
MIFTS: 48

Female Breast Carcinoma malady

Cancer diseases category

Summaries for Female Breast Carcinoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A breast carcinoma that is manifested in the female breast.

MalaCards: Female Breast Carcinoma, also known as mammary carcinoma of female breast, is related to breast cancer and male breast cancer. An important gene associated with Female Breast Carcinoma is CHGB (chromogranin B (secretogranin 1)), and among its related pathways are TGF-beta Receptor Signaling Pathway and Toll-like Receptor Pathway. The compounds estrogen and resveratrol have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related mouse phenotypes are renal/urinary system and embryogenesis.

Aliases & Classifications for Female Breast Carcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

female breast carcinoma 8 10 60
mammary carcinoma of female breast 8
female breast cancer 8


External Ids:

Disease Ontology8 DOID:7843, DOID:0050671
NCIt39 C2918

Related Diseases for Female Breast Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Female Breast Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.3ESR1, ERBB2, PGR, CDK4, BRCA1
2male breast cancer30.9BRCA1, PGR, ERBB2, ESR1
3prostate cancer30.4KLK3, BRCA1, CHGA, BLZF1, CD44, CDK4
4prostatitis30.1KLK3
5melanoma30.0MLH1, BLZF1, CDKN2A, CD44, CDK4, ENO2
6sporadic breast cancer10.2
7breast carcinoma in situ10.1
8breast disease10.1
9in situ carcinoma10.1
10progesterone-receptor positive breast cancer10.1
11phaeochromocytoma10.0CHGA
12gastrointestinal stromal tumor10.0ENO2
13wilms tumor10.0ENO2
14cerebral primitive neuroectodermal tumor10.0ENO2
15colon adenocarcinoma10.0MLH1
16ependymoma10.0ENO2
17acute leukemia10.0BLZF1
18gliosarcoma10.0CDK4
19myeloid leukemia10.0CDK4
20myocardial infarction10.0BLZF1
21uterine carcinosarcoma10.0ERBB2
22insulinoma10.0CHGA
23anaplastic large cell lymphoma10.0ENO2
24peritoneal carcinoma10.0BRCA1
25cystadenoma10.0BRCA1
26schizophrenia10.0CHGB
27hemangioblastoma10.0ENO2
28ischemia10.0BLZF1
29keratoacanthoma10.0MLH1
30sertoli-leydig cell tumor10.0PGR
31lipoma10.0CDK4
32prion disease10.0ENO2
33lichen sclerosus10.0CD44
34fallopian tube cancer10.0BRCA1
35arthritis10.0CD44
36pilocytic astrocytoma10.0CDK4
37multiple endocrine neoplasia10.0CHGA, CHGB
38alzheimer's disease10.0BLZF1, CHGB
39ulcerative colitis10.0TP53
40somatostatinoma10.0CHGA
41gastrinoma10.0ENO2, CHGA
42fibromatosis10.0PGR
43kidney cancer10.0TP53
44laryngeal benign neoplasm10.0TP53
45bloom syndrome10.0BRCA1
46deficiency anemia10.0BRCA1
47cerebral meningioma10.0PGR
48rheumatoid arthritis10.0CD44
49prostatic hypertrophy10.0KLK3
50parathyroid adenoma10.0CHGA, CHGB

Graphical network of the top 20 diseases related to Female Breast Carcinoma:



Diseases related to female breast carcinoma

Clinical Features for Female Breast Carcinoma

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Drugs & Therapeutics for Female Breast Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Female Breast Carcinoma

Drug clinical trials:

Search ClinicalTrials for Female Breast Carcinoma

Search NIH Clinical Center for Female Breast Carcinoma

Search CenterWatch for Female Breast Carcinoma

Genetic Tests for Female Breast Carcinoma

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Anatomical Context for Female Breast Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Female Breast Carcinoma:

32
Breast, Lymph node, Prostate

Animal Models for Female Breast Carcinoma or affiliated genes

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Sources:
36MGI
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Publications for Female Breast Carcinoma

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50PubMed
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Articles related to Female Breast Carcinoma:

(show all 46)
idTitleAuthorsYear
1
Risk factors of female breast carcinoma: a case control study at Puducherry. (23713049)
2013
2
Adenoid cystic carcinoma of female breast: A case report. (23562896)
2013
3
Intratumoral estrogen concentration and expression of estrogen-induced genes in male breast carcinoma: comparison with female breast carcinoma. (23096432)
2013
4
Prevalence of known prognostic factors in female breast carcinoma including oestrogen receptor, progesterone receptor and Her-2/neu status--a study in a tertiary care centre. (23936949)
2012
5
Prostate-specific antigen and hormone receptor expression in male and female breast carcinoma. (20863373)
2010
6
Age related association of Her-2/neu with prognostic markers in female breast carcinoma. (20810050)
2010
7
Serous papillary adenocarcinoma of the female genital organs and invasive micropapillary carcinoma of the breast. Are WT1, CA125, and GCDFP-15 useful in differential diagnosis? (18339419)
2008
8
Inter- and intra-ethnic differences for female breast carcinoma incidence in the continental United States and in the state of Hawaii. (16322891)
2006
9
Correlation of her-2/neu gene amplification with other prognostic and predictive factors in female breast carcinoma. (15982396)
2005
10
Continuous low-dose GM-CSF as salvage therapy in refractory recurrent breast or female genital tract carcinoma. (15934497)
2005
11
The incidence of malignant non-carcinomas of the female breast. (15090726)
2004
12
The role of CD44v3 expression in female breast carcinomas. (14998292)
2003
13
Carcinoma in situ of the female breast. A clinico-pathological, immunohistological, and DNA ploidy study. (12874968)
2003
14
Soluble adhesion molecules in female patients with breast carcinoma]. (12920795)
2003
15
Acute phase proteins in female patients with breast carcinoma]. (14577123)
2003
16
Status of HER-2 in male and female breast carcinoma. (11720677)
2001
17
Expression of oestrogen and progesterone receptors, Ki-67, p53 and BCL-2 proteins, cathepsin D, urokinase plasminogen activator and urokinase plasminogen activator-receptors in carcinomas of the female breast in an African population. (11957260)
2001
18
Flow cytometric DNA analysis using cytokeratin labeling for identification of tumor cells in carcinomas of the breast and the female genital tract. (11455036)
2001
19
Female breast carcinomas: nuclear and cytoplasmic proteins versus steroid receptors. (10756981)
2000
20
Comparative study of two androgen-induced markers (apolipoprotein D and pepsinogen C) in female and male breast carcinoma. (12678518)
2000
21
Biopsy confirmed benign breast disease, postmenopausal use of exogenous female hormones, and breast carcinoma risk. (11066044)
2000
22
Germline BRCA1 and HMLH1 mutations in a family with male and female breast carcinoma. (10709098)
2000
23
Low-stage carcinoma of the male breast. A histologic, immunohistochemical, and flow cytometric comparison with localized female breast carcinoma. (9894455)
1999
24
Verrucous carcinoma of the female breast. (10621880)
1999
25
Time trend of female breast carcinoma in situ by race and histology in Connecticut, USA. (9071907)
1997
26
CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract. (8981366)
1997
27
Allium vegetable consumption, garlic supplement intake, and female breast carcinoma incidence. (7749142)
1995
28
Analysis of MTS1/CDK4 in female breast carcinomas. (7889533)
1995
29
Surgeon's dilemma: in situ carcinoma of the female breast with special reference to limited surgery. (8435184)
1993
30
c-myc oncogene expression: a marker for females at risk of breast carcinoma. (8255078)
1993
31
Argyrophilia and granin (chromogranin/secretogranin) expression in female breast carcinomas. Their relationship to survival and other disease parameters. (1376022)
1992
32
Expression of tumour markers CA50, CEA and TPA in female breast carcinoma as related to histopathological findings and survival. (1567186)
1992
33
Hormone receptor status and mitotic activity as risk factors for recurrence and death in female breast carcinoma. (1768039)
1991
34
Steroid-hormone receptors in nonpalpable and more advanced stages of breast cancer. A contribution to the biology and natural history of carcinoma of the female breast. (2400967)
1990
35
The growth pattern of in situ carcinoma in the female breast. (2851304)
1988
36
Regional lymph node reactions related to hormone receptor status in female breast carcinoma. (4004508)
1985
37
Hormone receptor levels related to histological parameters of tumor-host relationships in female breast carcinoma. (6287111)
1982
38
Histochemically demonstrable enzyme activities and their independence of the hormone receptor content in female breast carcinoma. (6298092)
1982
39
Paracortical activity in the lymph nodes draining female breast carcinoma. (311901)
1979
40
X-chromatin (Barr bodies) correlated with the DNA content of lobular neoplasia and invasive lobular carcinoma in the female breast. (294765)
1979
41
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. V. PHENOL,4,4'-(DL-1,2-DIETHYL-ETHYLENE)DI- AND ANDROST-4-EN-3-ONE, 9-CHLORO-11-BETA, 17-BETA-DIHYDROXY-17-METHYL-. (14278041)
1965
42
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. IV. 17-BETA-AMINO-5-ALPHA-ANDROSTAN-11-BETA-OL. (14176991)
1964
43
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. III. ANDROST-4-EN-3-ONE-2ALPHA,17BETA-DIHYDROXY DIPROPIONATE AND ANDROST-4-EN-3-ONE-16ALPHA, 17BETA-DIHYDROXY DIPROPIONATE. (14050008)
1963
44
Hormonal therapy of metastatic female breast carcinoma. II. 2alpha-Methyl dihydrotestosterone propionate. (13706491)
1961
45
The present controversy in the treatment of female breast carcinoma. (13665202)
1959
46
Hormonal therapy of metastatic female breast carcinoma. I. 9 alpha-Bromo-11-ketoprogesterone. (13663018)
1959

Genetic Variations for Female Breast Carcinoma

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Expression for genes affiliated with Female Breast Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Female Breast Carcinoma

Search GEO for disease gene expression data for Female Breast Carcinoma.

Pathways for genes affiliated with Female Breast Carcinoma

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Sources:
37NCBI BioSystems Database, 59Tocris Bioscience, 12EMD Millipore, 51QIAGEN, 53Reactome, 52R&D Systems, 29KEGG, 4Cell Signaling Technology
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Pathways related to Female Breast Carcinoma according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CD44, ESR1
2
Hide members
9.7ERBB2, TP53
39.7MLH1, CDK4, PGR
49.6BRCA1, TP53
59.6TP53, BRCA1
6
Hide members
9.6CDK4, MLH1, BRCA1
79.5TP53, CDKN2A
89.5TP53, CDKN2A
99.4TP53, ERBB2, CDK4
10
Hide members
9.4MLH1, ERBB2, TP53
119.4TP53, CDK4, BRCA1
129.4TP53, CDK4, BRCA1
13
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.4TP53, MLH1, BRCA1
14
Hide members
9.3BLZF1, BRCA1
159.3KLK3, BRCA1, ESR1
169.3TP53, CDK4, CDKN2A
17
Hide members
9.3TP53, CDK4, CDKN2A
18
Transcription P53 signaling pathway
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9.3CDKN2A, CDK4, TP53
19
Hide members
9.3TP53, BRCA1, KLK3
20
Hide members
9.2BRCA1, MLH1, CDKN2A, CDK4
219.2CDKN2A, CD44, TP53
22
Hide members
9.0CDKN2A, CDK4, ERBB2, TP53
23
Hide members
9.0TP53, CDK4, BRCA1, KLK3
24
Hide members
9.0TP53, CDK4, CDKN2A, BRCA1
258.9BRCA1, CDK4, ESR1, TP53
26
Hide members
8.9CDKN2A, CD44, ERBB2, TP53
278.9TP53, ESR1, ERBB2, CD44
28
Cell cycle Cell cycle (generic schema)
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8.7BRCA1, CDKN2A, CDK4, PGR, ESR1
298.6BRCA1, CDK4, ERBB2, ESR1, TP53
30
Hide members
8.6BRCA1, CDK4, ERBB2, ESR1, TP53
318.6BRCA1, CDKN2A, CD44, ERBB2, TP53
328.4KLK3, MLH1, CDKN2A, CDK4, ERBB2, TP53
33
Hide members
8.2BRCA1, CDKN2A, CDK4, ERBB2, ESR1, TP53

Compounds for genes affiliated with Female Breast Carcinoma

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Female Breast Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 179)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6KLK3
2resveratrol44 59 11 2413.3ERBB2, PGR
3cycloheximide4410.2BRCA1, KLK3
4tamoxifen44 49 28 1113.0CHGA, PGR, ERBB2
5vincristine44 49 1112.0KLK3, BRCA1
6guanine44 11 2411.8ERBB2, BRCA1, KLK3
7adriamycin449.8CDKN2A, CD44, PGR
8estracyt449.6ENO2, KLK3, CHGA
9butyrate449.5BLZF1, KLK3
10megestrol acetate449.4PGR, ERBB2, ESR1, KLK3
115-methylcytosine44 2410.3MLH1, BRCA1, CDKN2A, TP53
12serine449.2KLK3, ERBB2, CD44, CHGB, BRCA1
13gnrh449.2CHGA, CD44, PGR, KLK3, ERBB2
14p002449.2ERBB2, CD44, CHGA, BRCA1, MLH1
15dexamethasone44 49 28 1112.1ENO2, CDK4, CHGB, KLK3, CDKN2A
16biotin44 11 2411.1CDKN2A, ERBB2, CD44, MLH1, KLK3
17etoposide44 49 59 1112.1ERBB2, BRCA1, MLH1, CHGA, KLK3, CD44
18flutamide44 59 1111.0PGR, KLK3, CHGA, ESR1, ENO2
19bromodeoxyuridine449.0ENO2, CDK4, CD44, CHGA, MLH1
20taxane448.9KLK3, ERBB2, ESR1, TP53, PGR
21geldanamycin44 49 59 1111.9TP53, CDK4, ERBB2, PGR, ESR1
22indole-3-carbinol448.9KLK3, CDK4, ESR1, TP53, BRCA1
23folate448.9ERBB2, PGR, CDKN2A, MLH1, BRCA1
24thymidylate448.8CDKN2A, TP53, BRCA1, MLH1, ERBB2, CDK4
25diethylstilbestrol44 28 1110.7KLK3, PGR, ENO2, ESR1
26vitamin d448.7CD44, KLK3, CHGA, CDK4, ERBB2, ESR1
27camptothecin44 59 1110.7KLK3, BRCA1, CDKN2A, MLH1, CDK4, TP53
28n-(4-hydroxyphenyl)retinamide448.7ERBB2, TP53, CDK4, ESR1
295-aza-2deoxycytidine448.5BRCA1, ESR1, MLH1, CDKN2A, PGR, TP53
30methotrexate44 49 1110.5CDKN2A, PGR, BRCA1, ESR1, ENO2, ERBB2
31cyclophosphamide44 49 1110.4CHGA, CD44, PGR, ERBB2, ESR1, BRCA1
32agarose448.3CD44, BLZF1, BRCA1, MLH1, CDKN2A
33formaldehyde44 249.2KLK3, CHGA, CD44, ERBB2, ENO2, BLZF1
345fluorouracil448.1ERBB2, CDK4, BRCA1, MLH1, CDKN2A, PGR
35mg 13244 599.0TP53, ESR1, CDKN2A, BLZF1, BRCA1
36genistein44 28 59 2 11 2413.0CDK4, ERBB2, CDKN2A, PGR, ESR1, BLZF1
37carboplatin44 49 119.8CD44, CDK4, ERBB2, ENO2, TP53, CHGA
38docetaxel44 49 59 1110.7ESR1, TP53, KLK3, BRCA1, CDKN2A, PGR
39steroid447.6BRCA1, CDKN2A, CD44, CDK4, ERBB2, ESR1
40arginine447.6CHGA, CD44, ERBB2, TP53, CDK4, CDKN2A
41paraffin447.6ERBB2, ENO2, ESR1, CDK4, CD44, CHGA
42paclitaxel44 49 119.5TP53, CD44, CDKN2A, CHGA, MLH1, BRCA1
43oxygen44 248.4CHGA, MLH1, ENO2, CDK4, CD44, CDKN2A
44doxorubicin44 49 119.4CD44, CDK4, PGR, ESR1, TP53, ERBB2
45alanine447.3CDK4, ERBB2, CD44, BRCA1, MLH1, CDKN2A
46cisplatin44 49 59 119.9CDK4, CDKN2A, MLH1, BRCA1, ERBB2, ENO2
47testosterone44 59 11 249.6ESR1, ERBB2, PGR, CDK4, CD44, CDKN2A
48retinoic acid44 247.4ENO2, CHGA, PGR, TP53, ESR1, CDK4
49progesterone44 59 28 11 2410.2CDK4, PGR, ERBB2, ENO2, ESR1, TP53
50vegf446.0KLK3, BRCA1, MLH1, CDKN2A, CD44, CDK4

GO Terms for genes affiliated with Female Breast Carcinoma

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Sources:
16Gene Ontology
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Cellular components related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.2TP53, ESR1, PGR, CDK4, CDKN2A, BRCA1

Biological processes related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of immature T cell proliferation in thymusGO:0330889.8ERBB2, CDKN2A
2replicative senescenceGO:0903999.4CDKN2A, TP53
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.3TP53, BRCA1
4positive regulation of cell cycle arrestGO:0711589.3TP53, CDKN2A, BRCA1
5cell cycle arrestGO:0070508.9TP53, VASH1, CDKN2A

Molecular functions related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.2CDKN2A, TP53
2enzyme bindingGO:0198998.0TP53, ESR1, PGR, BLZF1, BRCA1
3protein bindingGO:0055156.7BRCA1, MLH1, CHGB, CDKN2A, CD44, CDK4

Products for genes affiliated with Female Breast Carcinoma

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  • Antibodies
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Sources for Female Breast Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet