MCID: FML027
MIFTS: 43

Female Breast Carcinoma malady

Cancer diseases category

Aliases & Classifications for Female Breast Carcinoma

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Female Breast Carcinoma, Aliases & Descriptions:

Name: Female Breast Carcinoma 9 11 60
Malignant Neoplasm of Female Breast 60
 
Mammary Carcinoma of Female Breast 9
Female Breast Cancer 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:7843, DOID:0050671
NCIt38 C2918

Summaries for Female Breast Carcinoma

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Disease Ontology:9 A breast carcinoma that is manifested in the female breast.

MalaCards based summary: Female Breast Carcinoma, also known as malignant neoplasm of female breast, is related to breast cancer and melanoma. An important gene associated with Female Breast Carcinoma is CHGB (chromogranin B (secretogranin 1)), and among its related pathways are Doxorubicin Pathway, Pharmacokinetics and Ovarian Infertility Genes. The compounds megestrol acetate and estracyt have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Related Diseases for Female Breast Carcinoma

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Diseases related to Female Breast Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.2BRCA1, PGR, ESR1, ERBB2, CDK4
2melanoma29.1MLH1, BLZF1, TP53, ENO2, CDKN2A, CDK4
3mismatch repair cancer syndrome10.5MLH1
4somatostatinoma10.5CHGA
5cerebral meningioma10.5PGR
6ewing's family of tumors10.5ENO2
7fallopian tube cancer10.5BRCA1
8subependymal giant cell astrocytoma10.5ENO2
9cystadenoma10.4BRCA1
10actinic keratosis10.4TP53
11endocrine gland cancer10.4MLH1, CHGA
12biliary tract neoplasm10.4MLH1, ERBB2
13alveolar soft-part sarcoma10.4ENO2, MLH1
14gliosarcoma10.4CDK4
15pineocytoma10.4CHGA, ENO2
16lynch syndrome10.4MLH1, BRCA1
17parathyroid adenoma10.3CHGB, CHGA
18merkel cell carcinoma10.3ENO2, CHGA
19sertoli cell tumor10.3PGR, ENO2
20ganglioglioma10.3CHGA, ENO2
21glucagonoma10.3CHGB, CHGA, ENO2
22paraganglioma10.3ENO2, CHGA, CHGB
23medullary thyroid carcinoma, familial10.3CHGB, CHGA, ENO2
24neuroblastoma10.3TP53, ENO2
25rhabdomyosarcoma 2, alveolar10.3ENO2, CDK4
26neuroendocrine tumor10.3CHGB, CHGA, ENO2
27neurofibromatosis10.3MLH1, BLZF1, ENO2
28meningioma, familial10.3PGR, ESR1
29cribriform carcinoma10.3PGR, ESR1
30carcinoid syndrome10.3CHGB, CHGA, ENO2
31progesterone resistance10.3PGR, ESR1
32malignant mixed mullerian tumor10.3PGR, ESR1
33gastrinoma10.3CHGA, ENO2
34leiomyomatosis10.3PGR, ESR1
35adenosarcoma10.3PGR, ESR1
36gallbladder cancer10.3TP53, MLH1
37myoma10.2PGR, ESR1
38pituitary adenoma10.2CHGB, CHGA, CDK4
39endometrial stromal sarcoma10.2PGR, ESR1
40fanconi anemia, complementation group a10.2MLH1, BLZF1, BRCA1
41uterine fibroid10.2PGR, ESR1
42stomach cancer10.2TP53, ERBB2
43prolactinoma10.2ESR1, CHGB, CHGA
44lymphangioleiomyomatosis10.2ESR1, PGR
45angiomyolipoma10.2PGR, ESR1
46ganglioneuroblastoma10.2ENO2, CD44
47pituitary tumors10.2ESR1, CHGB, CHGA
48neutropenia10.2BLZF1, ERBB2, KLK3
49pheochromocytoma10.2ENO2, CHGA, CHGB
50breast disease10.2ERBB2, ESR1, PGR

Graphical network of the top 20 diseases related to Female Breast Carcinoma:



Diseases related to female breast carcinoma

Symptoms for Female Breast Carcinoma

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Drugs & Therapeutics for Female Breast Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Female Breast Carcinoma

Search NIH Clinical Center for Female Breast Carcinoma

Genetic Tests for Female Breast Carcinoma

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Anatomical Context for Female Breast Carcinoma

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MalaCards organs/tissues related to Female Breast Carcinoma:

31
Breast, Lymph node, Prostate

Animal Models for Female Breast Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Female Breast Carcinoma:

35 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4CD44, CDK4, CDKN2A, ESR1, TP53
2MP:00053678.4TP53, BRCA1, ESR1, CHGA, CDK4, CD44
3MP:00053808.1TP53, BRCA1, PGR, ESR1, ERBB2, CDKN2A
4MP:00053817.9MLH1, TP53, BRCA1, ESR1, ERBB2, CDKN2A
5MP:00053697.8TP53, BRCA1, PGR, ESR1, ERBB2, CDKN2A
6MP:00053887.8TP53, BRCA1, ESR1, ERBB2, ENO2, CDKN2A
7MP:00053717.7BLZF1, TP53, BRCA1, PGR, ESR1, ERBB2
8MP:00053977.7TP53, BRCA1, PGR, ESR1, CDKN2A, CDK4
9MP:00020067.6MLH1, TP53, BRCA1, PGR, ESR1, ERBB2
10MP:00107717.6MLH1, TP53, BRCA1, PGR, ESR1, ERBB2
11MP:00053787.6TP53, BRCA1, ESR1, CHGA, ERBB2, CDKN2A
12MP:00053877.5TP53, BRCA1, PGR, ESR1, CDKN2A, CDK4
13MP:00053857.4TP53, BRCA1, PGR, ESR1, CHGA, VASH1
14MP:00053897.4MLH1, TP53, BRCA1, PGR, ESR1, CHGA
15MP:00053907.3BLZF1, TP53, BRCA1, PGR, ESR1, ERBB2
16MP:00036317.2TP53, BRCA1, ESR1, CHGB, ERBB2, ENO2
17MP:00053867.2TP53, BRCA1, PGR, ESR1, ERBB2, ENO2
18MP:00107687.2MLH1, TP53, BRCA1, PGR, ESR1, CHGA
19MP:00053797.2CD44, MLH1, TP53, BRCA1, PGR, ESR1
20MP:00053767.1MLH1, TP53, BRCA1, PGR, ESR1, CHGB
21MP:00053847.1MLH1, TP53, BRCA1, PGR, ESR1, ERBB2

Publications for Female Breast Carcinoma

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Articles related to Female Breast Carcinoma:

(show all 28)
idTitleAuthorsYear
1
Risk factors of female breast carcinoma: a case control study at Puducherry. (23713049)
2013
2
Intratumoral estrogen concentration and expression of estrogen-induced genes in male breast carcinoma: comparison with female breast carcinoma. (23096432)
2013
3
Prevalence of known prognostic factors in female breast carcinoma including oestrogen receptor, progesterone receptor and Her-2/neu status--a study in a tertiary care centre. (23936949)
2012
4
Prostate-specific antigen and hormone receptor expression in male and female breast carcinoma. (20863373)
2010
5
Age related association of Her-2/neu with prognostic markers in female breast carcinoma. (20810050)
2010
6
Inter- and intra-ethnic differences for female breast carcinoma incidence in the continental United States and in the state of Hawaii. (16322891)
2006
7
Correlation of her-2/neu gene amplification with other prognostic and predictive factors in female breast carcinoma. (15982396)
2005
8
The role of CD44v3 expression in female breast carcinomas. (14998292)
2003
9
Status of HER-2 in male and female breast carcinoma. (11720677)
2001
10
Female breast carcinomas: nuclear and cytoplasmic proteins versus steroid receptors. (10756981)
2000
11
Germline BRCA1 and HMLH1 mutations in a family with male and female breast carcinoma. (10709098)
2000
12
Low-stage carcinoma of the male breast. A histologic, immunohistochemical, and flow cytometric comparison with localized female breast carcinoma. (9894455)
1999
13
Time trend of female breast carcinoma in situ by race and histology in Connecticut, USA. (9071907)
1997
14
Allium vegetable consumption, garlic supplement intake, and female breast carcinoma incidence. (7749142)
1995
15
Analysis of MTS1/CDK4 in female breast carcinomas. (7889533)
1995
16
Argyrophilia and granin (chromogranin/secretogranin) expression in female breast carcinomas. Their relationship to survival and other disease parameters. (1376022)
1992
17
Expression of tumour markers CA50, CEA and TPA in female breast carcinoma as related to histopathological findings and survival. (1567186)
1992
18
Hormone receptor status and mitotic activity as risk factors for recurrence and death in female breast carcinoma. (1768039)
1991
19
Regional lymph node reactions related to hormone receptor status in female breast carcinoma. (4004508)
1985
20
Hormone receptor levels related to histological parameters of tumor-host relationships in female breast carcinoma. (6287111)
1982
21
Histochemically demonstrable enzyme activities and their independence of the hormone receptor content in female breast carcinoma. (6298092)
1982
22
Paracortical activity in the lymph nodes draining female breast carcinoma. (311901)
1979
23
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. V. PHENOL,4,4'-(DL-1,2-DIETHYL-ETHYLENE)DI- AND ANDROST-4-EN-3-ONE, 9-CHLORO-11-BETA, 17-BETA-DIHYDROXY-17-METHYL-. (14278041)
1965
24
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. IV. 17-BETA-AMINO-5-ALPHA-ANDROSTAN-11-BETA-OL. (14176991)
1964
25
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. III. ANDROST-4-EN-3-ONE-2ALPHA,17BETA-DIHYDROXY DIPROPIONATE AND ANDROST-4-EN-3-ONE-16ALPHA, 17BETA-DIHYDROXY DIPROPIONATE. (14050008)
1963
26
Hormonal therapy of metastatic female breast carcinoma. II. 2alpha-Methyl dihydrotestosterone propionate. (13706491)
1961
27
The present controversy in the treatment of female breast carcinoma. (13665202)
1959
28
Hormonal therapy of metastatic female breast carcinoma. I. 9 alpha-Bromo-11-ketoprogesterone. (13663018)
1959

Variations for Female Breast Carcinoma

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Expression for genes affiliated with Female Breast Carcinoma

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Search GEO for disease gene expression data for Female Breast Carcinoma.

Pathways for genes affiliated with Female Breast Carcinoma

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Pathways related to Female Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7MLH1, TP53
29.7CDK4, PGR, MLH1
39.6BRCA1, TP53
49.6BRCA1, TP53
59.6BRCA1, TP53
69.6BRCA1, TP53
7
Show member pathways
9.6CDK4, BRCA1, MLH1
8
Show member pathways
Cell cycle ESR1 regulation of G1 S transition58
Immune response MIF JAB1 signaling58
Cell cycle Cell cycle generic schema 58
9.5CDK4, ESR1, PGR
99.5CDKN2A, TP53
10
Show member pathways
9.5CDKN2A, TP53
11
Show member pathways
Signal transduction PTEN pathway58
9.4ERBB2, TP53, MLH1
12
Show member pathways
FOXA transcription factor networks36
9.4BRCA1, ESR1, KLK3
13
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation58
9.4CDK4, CDKN2A, BRCA1
149.4BRCA1, TP53, MLH1
159.4TP53, ERBB2, CDK4
169.3TP53, BRCA1, CDK4
17
Show member pathways
9.3CDK4, BRCA1, TP53
189.3TP53, BRCA1, CDK4
19
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.3ERBB2, ESR1, TP53
20
Show member pathways
9.2TP53, CDKN2A, CDK4
21
Show member pathways
Cell cycle36
9.2TP53, CDKN2A, CDK4
229.2CDK4, CDKN2A, TP53
23
Show member pathways
9.2TP53, CDKN2A, CDK4
249.2TP53, CDKN2A, CDK4
259.2CDK4, CDKN2A, TP53
269.2CDK4, CDKN2A, TP53
279.1CD44, CDKN2A, TP53
28
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.0TP53, BRCA1, KLK3, CDK4
29
Show member pathways
9.0TP53, BRCA1, ESR1, CDK4
309.0TP53, BRCA1, ESR1, CDK4
31
Show member pathways
8.9TP53, ERBB2, CDKN2A, CDK4
328.9TP53, ESR1, ERBB2, CD44
33
Show member pathways
DNA damage response36
8.9CDK4, CDKN2A, BRCA1, TP53
348.9CD44, CDK4, ESR1, TP53
35
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
8.8TP53, ERBB2, CDKN2A, CD44
368.7TP53, BRCA1, ESR1, ERBB2, CDK4
37
Show member pathways
8.6MLH1, TP53, BRCA1, CDKN2A, CDK4
388.5CD44, CDKN2A, ERBB2, BRCA1, TP53
398.3MLH1, TP53, ERBB2, KLK3, CDKN2A, CDK4
40
Show member pathways
Signaling Pathways in Glioblastoma36
8.3CDK4, CDKN2A, KLK3, ERBB2, BRCA1, TP53
41
Show member pathways
8.2CDK4, CDKN2A, ERBB2, ESR1, BRCA1, TP53
42
Show member pathways
8.2TP53, BRCA1, ESR1, ERBB2, CDKN2A, CDK4
43
Show member pathways
8.1BLZF1, TP53, BRCA1, CDKN2A, CDK4

Compounds for genes affiliated with Female Breast Carcinoma

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Compounds related to Female Breast Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 215)
idCompoundScoreTop Affiliating Genes
1megestrol acetate439.5PGR, ERBB2, KLK3, ESR1
2estracyt439.5CHGA, ENO2, KLK3
35-methylcytosine43 2410.2MLH1, CDKN2A, BRCA1, TP53
4p002439.2CHGA, BRCA1, MLH1, ERBB2, CD44
5flutamide43 59 1211.1PGR, ENO2, KLK3, ESR1, CHGA
6taxane439.1ERBB2, KLK3, ESR1, PGR, TP53
7geldanamycin43 49 59 1212.0PGR, ESR1, TP53, CDK4, ERBB2
8biotin43 24 1211.0CD44, CDKN2A, KLK3, MLH1, ERBB2
9indole-3-carbinol439.0KLK3, ESR1, BRCA1, CDK4, TP53
10folate438.9BRCA1, PGR, CDKN2A, ERBB2, MLH1
11bromodeoxyuridine438.9CHGA, MLH1, CDK4, ENO2, CD44
12gnrh438.9PGR, CHGA, ERBB2, CD44, ESR1, KLK3
13resveratrol43 59 24 1211.8BRCA1, PGR, ESR1, ERBB2, CDK4, TP53
14thymidylate438.8CDKN2A, CDK4, ERBB2, BRCA1, TP53, MLH1
15vitamin d438.7KLK3, CD44, CHGA, ESR1, CDK4, ERBB2
16camptothecin43 59 1210.7CDKN2A, BRCA1, CDK4, KLK3, MLH1, TP53
17diethylstilbestrol43 28 1210.7PGR, KLK3, ENO2, ESR1
185-aza-2deoxycytidine438.6MLH1, BRCA1, CDKN2A, ESR1, TP53, PGR
19vincristine43 49 1210.6CDKN2A, TP53, BRCA1, KLK3, CD44
20adriamycin438.6CD44, ERBB2, BRCA1, TP53, CDKN2A, PGR
21guanine43 24 1210.6TP53, CHGA, ERBB2, KLK3, ENO2, BRCA1
22methotrexate49 43 1210.6PGR, ENO2, CDKN2A, ERBB2, ESR1, BRCA1
23cyclophosphamide43 49 1210.5PGR, ERBB2, ESR1, CHGA, BRCA1, TP53
24tamoxifen43 49 28 1211.4PGR, BRCA1, TP53, ESR1, CHGA, CD44
25formaldehyde43 249.2ENO2, KLK3, ERBB2, CD44, CHGA, BLZF1
265fluorouracil438.1MLH1, CDK4, PGR, CDKN2A, ERBB2, TP53
27agarose438.1CDKN2A, MLH1, BLZF1, CD44, BRCA1
28mg 13243 599.0BRCA1, ESR1, CDKN2A, BLZF1, TP53
29etoposide43 49 59 1211.0CD44, MLH1, TP53, BRCA1, KLK3, ERBB2
30genistein43 28 59 2 24 1213.0PGR, CDK4, BLZF1, CDKN2A, BRCA1, ESR1
31butyrate437.9BLZF1, TP53, KLK3, CDKN2A, CDK4, CD44
32dexamethasone43 49 28 1210.8CD44, CDK4, CDKN2A, ENO2, KLK3, CHGA
33docetaxel43 49 59 1210.8ERBB2, CDKN2A, PGR, BRCA1, TP53, ENO2
34carboplatin43 49 129.7CDK4, CD44, ENO2, KLK3, ERBB2, MLH1
35arginine437.5CDKN2A, CHGA, ERBB2, MLH1, CD44, TP53
36doxorubicin43 49 129.4CDK4, CDKN2A, KLK3, ERBB2, ESR1, PGR
37oxygen43 248.4CDKN2A, CD44, CDK4, ENO2, CHGA, MLH1
38alanine437.2ENO2, CDKN2A, PGR, CDK4, CD44, MLH1
39paclitaxel43 49 129.1MLH1, TP53, BRCA1, PGR, ESR1, CHGA
40tyrosine437.1ENO2, ERBB2, BRCA1, BLZF1, CHGA, MLH1
41serine436.9CD44, CHGB, CHGA, BRCA1, ERBB2, KLK3
42steroid436.8CD44, CDK4, CDKN2A, KLK3, ERBB2, CHGA
43paraffin436.6KLK3, CHGA, ESR1, PGR, BRCA1, TP53
44cycloheximide436.6KLK3, CDKN2A, CDK4, ERBB2, CHGA, ESR1
45testosterone43 59 24 129.5CDK4, BRCA1, PGR, CDKN2A, ESR1, CHGA
46cisplatin43 49 59 129.4CHGA, ERBB2, ENO2, CDKN2A, CDK4, CD44
47retinoic acid43 247.4CHGA, MLH1, CDKN2A, CDK4, CD44, ENO2
48progesterone43 28 59 24 1210.1CD44, CDK4, CDKN2A, ENO2, ERBB2, CHGA
49vegf436.0CD44, CDK4, CDKN2A, ENO2, KLK3, ERBB2
50estrogen435.6CD44, CDK4, CDKN2A, ENO2, KLK3, ERBB2

GO Terms for genes affiliated with Female Breast Carcinoma

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Cellular components related to Female Breast Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166049.5CDKN2A, TP53
2nucleoplasmGO:00056547.9CDK4, CDKN2A, ESR1, PGR, BRCA1, TP53

Biological processes related to Female Breast Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of immature T cell proliferation in thymusGO:00330889.8CDKN2A, ERBB2
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.5TP53, BRCA1
3replicative senescenceGO:00903999.5CDKN2A, TP53
4positive regulation of cell cycle arrestGO:00711589.3CDKN2A, BRCA1, TP53
5regulation of apoptotic processGO:00429819.3ESR1, BRCA1, TP53
6cell cycle arrestGO:00070508.6CDKN2A, VASH1, TP53

Molecular functions related to Female Breast Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:00054969.8ESR1, PGR
2MDM2/MDM4 family protein bindingGO:00973719.4TP53, CDKN2A
3ubiquitin protein ligase bindingGO:00316258.5BRCA1, TP53, BLZF1
4enzyme bindingGO:00198998.2ESR1, PGR, BRCA1, TP53, BLZF1
5protein bindingGO:00055156.7PGR, BRCA1, TP53, MLH1, ESR1, CHGB

Products for genes affiliated with Female Breast Carcinoma

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  • Antibodies
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  • Kits and Assays

Sources for Female Breast Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet