MCID: FML027
MIFTS: 42

Female Breast Carcinoma malady

Cancer category

Summaries for Female Breast Carcinoma

Sources:
8Disease Ontology, 33MalaCards
See all sources

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Disease Ontology:8 A breast carcinoma that is manifested in the female breast.

MalaCards: Female Breast Carcinoma, also known as mammary carcinoma of female breast, is related to male breast cancer and sporadic breast cancer. An important gene associated with Female Breast Carcinoma is CHGB (chromogranin B (secretogranin 1)), and among its related pathways are TGF-beta Receptor Signaling Pathway and Toll-like Receptor Pathway. The compounds estrogen and resveratrol have been mentioned in the context of this disorder. Affiliated tissues include lymph node, breast and prostate, and related mouse phenotypes are renal/urinary system and embryogenesis.

Aliases & Classifications for Female Breast Carcinoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

female breast carcinoma 8 10 61
mammary carcinoma of female breast 8
female breast cancer 8


External Ids:

Disease Ontology8 DOID:7843, DOID:0050671
NCIt40 C2918

Related Diseases for Female Breast Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Female Breast Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1male breast cancer31.0BRCA1, PGR, ERBB2, ESR1
2sporadic breast cancer10.2
3radiation induced cancer10.1
4breast cancer, somatic10.1
5phaeochromocytoma10.0CHGA
6gastrointestinal stromal tumor10.0ENO2
7wilms tumor10.0ENO2
8cerebral primitive neuroectodermal tumor10.0ENO2
9colon adenocarcinoma10.0MLH1
10ependymoma10.0ENO2
11acute leukemia10.0BLZF1
12gliosarcoma10.0CDK4
13myeloid leukemia10.0CDK4
14myocardial infarction10.0BLZF1
15uterine carcinosarcoma10.0ERBB2
16insulinoma10.0CHGA
17anaplastic large cell lymphoma10.0ENO2
18peritoneal carcinoma10.0BRCA1
19cystadenoma10.0BRCA1
20schizophrenia10.0CHGB
21hemangioblastoma10.0ENO2
22ischemia10.0BLZF1
23keratoacanthoma10.0MLH1
24sertoli-leydig cell tumor10.0PGR
25lipoma10.0CDK4
26prion disease10.0ENO2
27lichen sclerosus10.0CD44
28arthritis10.0CD44
29fallopian tube cancer10.0BRCA1
30pilocytic astrocytoma10.0CDK4
31multiple endocrine neoplasia10.0CHGA, CHGB
32alzheimer's disease10.0BLZF1, CHGB
33prostatitis10.0KLK3
34ulcerative colitis10.0TP53
35somatostatinoma10.0CHGA
36gastrinoma10.0ENO2, CHGA
37fibromatosis10.0PGR
38kidney cancer10.0TP53
39laryngeal carcinoma10.0TP53
40bloom syndrome10.0BRCA1
41deficiency anemia10.0BRCA1
42cerebral meningioma10.0PGR
43rheumatoid arthritis10.0CD44
44prostatic hypertrophy10.0KLK3
45parathyroid adenoma10.0CHGA, CHGB
46ganglioglioma10.0CHGA, ENO2
47chondrosarcoma10.0ENO2, CDK4
48turcot syndrome10.0MLH1
49biliary tract cancer10.0MLH1, ERBB2
50teratoma10.0ENO2

Graphical network of the top 20 diseases related to Female Breast Carcinoma:



Diseases related to female breast carcinoma

Clinical Features for Female Breast Carcinoma

Drugs & Therapeutics for Female Breast Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Female Breast Carcinoma

Drug clinical trials:

Search ClinicalTrials for Female Breast Carcinoma

Search NIH Clinical Center for Female Breast Carcinoma

Search CenterWatch for Female Breast Carcinoma

Genetic Tests for Female Breast Carcinoma

Anatomical Context for Female Breast Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Female Breast Carcinoma:

33
Lymph node, Breast, Prostate

Animal Models for Female Breast Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Female Breast Carcinoma

Sources:
51PubMed
See all sources

Articles related to Female Breast Carcinoma:

(show all 46)
idTitleAuthorsYear
1
Risk factors of female breast carcinoma: a case control study at Puducherry. (23713049)
2013
2
Adenoid cystic carcinoma of female breast: A case report. (23562896)
2013
3
Intratumoral estrogen concentration and expression of estrogen-induced genes in male breast carcinoma: comparison with female breast carcinoma. (23096432)
2013
4
Prevalence of known prognostic factors in female breast carcinoma including oestrogen receptor, progesterone receptor and Her-2/neu status--a study in a tertiary care centre. (23936949)
2012
5
Prostate-specific antigen and hormone receptor expression in male and female breast carcinoma. (20863373)
2010
6
Age related association of Her-2/neu with prognostic markers in female breast carcinoma. (20810050)
2010
7
Serous papillary adenocarcinoma of the female genital organs and invasive micropapillary carcinoma of the breast. Are WT1, CA125, and GCDFP-15 useful in differential diagnosis? (18339419)
2008
8
Inter- and intra-ethnic differences for female breast carcinoma incidence in the continental United States and in the state of Hawaii. (16322891)
2006
9
Correlation of her-2/neu gene amplification with other prognostic and predictive factors in female breast carcinoma. (15982396)
2005
10
Continuous low-dose GM-CSF as salvage therapy in refractory recurrent breast or female genital tract carcinoma. (15934497)
2005
11
The incidence of malignant non-carcinomas of the female breast. (15090726)
2004
12
The role of CD44v3 expression in female breast carcinomas. (14998292)
2003
13
Carcinoma in situ of the female breast. A clinico-pathological, immunohistological, and DNA ploidy study. (12874968)
2003
14
Soluble adhesion molecules in female patients with breast carcinoma]. (12920795)
2003
15
Acute phase proteins in female patients with breast carcinoma]. (14577123)
2003
16
Status of HER-2 in male and female breast carcinoma. (11720677)
2001
17
Expression of oestrogen and progesterone receptors, Ki-67, p53 and BCL-2 proteins, cathepsin D, urokinase plasminogen activator and urokinase plasminogen activator-receptors in carcinomas of the female breast in an African population. (11957260)
2001
18
Flow cytometric DNA analysis using cytokeratin labeling for identification of tumor cells in carcinomas of the breast and the female genital tract. (11455036)
2001
19
Female breast carcinomas: nuclear and cytoplasmic proteins versus steroid receptors. (10756981)
2000
20
Comparative study of two androgen-induced markers (apolipoprotein D and pepsinogen C) in female and male breast carcinoma. (12678518)
2000
21
Biopsy confirmed benign breast disease, postmenopausal use of exogenous female hormones, and breast carcinoma risk. (11066044)
2000
22
Germline BRCA1 and HMLH1 mutations in a family with male and female breast carcinoma. (10709098)
2000
23
Low-stage carcinoma of the male breast. A histologic, immunohistochemical, and flow cytometric comparison with localized female breast carcinoma. (9894455)
1999
24
Verrucous carcinoma of the female breast. (10621880)
1999
25
Time trend of female breast carcinoma in situ by race and histology in Connecticut, USA. (9071907)
1997
26
CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract. (8981366)
1997
27
Allium vegetable consumption, garlic supplement intake, and female breast carcinoma incidence. (7749142)
1995
28
Analysis of MTS1/CDK4 in female breast carcinomas. (7889533)
1995
29
Surgeon's dilemma: in situ carcinoma of the female breast with special reference to limited surgery. (8435184)
1993
30
c-myc oncogene expression: a marker for females at risk of breast carcinoma. (8255078)
1993
31
Argyrophilia and granin (chromogranin/secretogranin) expression in female breast carcinomas. Their relationship to survival and other disease parameters. (1376022)
1992
32
Expression of tumour markers CA50, CEA and TPA in female breast carcinoma as related to histopathological findings and survival. (1567186)
1992
33
Hormone receptor status and mitotic activity as risk factors for recurrence and death in female breast carcinoma. (1768039)
1991
34
Steroid-hormone receptors in nonpalpable and more advanced stages of breast cancer. A contribution to the biology and natural history of carcinoma of the female breast. (2400967)
1990
35
The growth pattern of in situ carcinoma in the female breast. (2851304)
1988
36
Regional lymph node reactions related to hormone receptor status in female breast carcinoma. (4004508)
1985
37
Hormone receptor levels related to histological parameters of tumor-host relationships in female breast carcinoma. (6287111)
1982
38
Histochemically demonstrable enzyme activities and their independence of the hormone receptor content in female breast carcinoma. (6298092)
1982
39
Paracortical activity in the lymph nodes draining female breast carcinoma. (311901)
1979
40
X-chromatin (Barr bodies) correlated with the DNA content of lobular neoplasia and invasive lobular carcinoma in the female breast. (294765)
1979
41
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. V. PHENOL,4,4'-(DL-1,2-DIETHYL-ETHYLENE)DI- AND ANDROST-4-EN-3-ONE, 9-CHLORO-11-BETA, 17-BETA-DIHYDROXY-17-METHYL-. (14278041)
1965
42
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. IV. 17-BETA-AMINO-5-ALPHA-ANDROSTAN-11-BETA-OL. (14176991)
1964
43
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. III. ANDROST-4-EN-3-ONE-2ALPHA,17BETA-DIHYDROXY DIPROPIONATE AND ANDROST-4-EN-3-ONE-16ALPHA, 17BETA-DIHYDROXY DIPROPIONATE. (14050008)
1963
44
Hormonal therapy of metastatic female breast carcinoma. II. 2alpha-Methyl dihydrotestosterone propionate. (13706491)
1961
45
The present controversy in the treatment of female breast carcinoma. (13665202)
1959
46
Hormonal therapy of metastatic female breast carcinoma. I. 9 alpha-Bromo-11-ketoprogesterone. (13663018)
1959

Genetic Variations for Female Breast Carcinoma

Expression for genes affiliated with Female Breast Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Female Breast Carcinoma

Search GEO for disease gene expression data for Female Breast Carcinoma.

Pathways for genes affiliated with Female Breast Carcinoma

Sources:
38NCBI BioSystems Database, 60Tocris Bioscience, 12EMD Millipore, 52QIAGEN, 54Reactome, 53R&D Systems, 30KEGG, 4Cell Signaling Technology
See all sources

Pathways related to Female Breast Carcinoma according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CD44, ESR1
2
Hide members
9.7ERBB2, TP53
39.7MLH1, CDK4, PGR
49.6BRCA1, TP53
59.6TP53, BRCA1
6
Hide members
9.6CDK4, MLH1, BRCA1
79.5TP53, CDKN2A
89.5TP53, CDKN2A
99.4TP53, ERBB2, CDK4
10
Hide members
9.4MLH1, ERBB2, TP53
119.4TP53, CDK4, BRCA1
129.4TP53, CDK4, BRCA1
13
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
9.4TP53, MLH1, BRCA1
14
Hide members
9.3BLZF1, BRCA1
159.3KLK3, BRCA1, ESR1
169.3TP53, CDK4, CDKN2A
17
Hide members
9.3TP53, CDK4, CDKN2A
18
Transcription P53 signaling pathway
Hide members
9.3CDKN2A, CDK4, TP53
19
Hide members
9.3TP53, BRCA1, KLK3
20
Hide members
9.2BRCA1, MLH1, CDKN2A, CDK4
219.2CDKN2A, CD44, TP53
22
Hide members
9.0CDKN2A, CDK4, ERBB2, TP53
23
Hide members
9.0TP53, CDK4, BRCA1, KLK3
24
Hide members
9.0TP53, CDK4, CDKN2A, BRCA1
258.9BRCA1, CDK4, ESR1, TP53
26
Hide members
8.9CDKN2A, CD44, ERBB2, TP53
278.9TP53, ESR1, ERBB2, CD44
28
Cell cycle Cell cycle (generic schema)
Hide members
8.7BRCA1, CDKN2A, CDK4, PGR, ESR1
298.6BRCA1, CDK4, ERBB2, ESR1, TP53
30
Hide members
8.6BRCA1, CDK4, ERBB2, ESR1, TP53
318.6BRCA1, CDKN2A, CD44, ERBB2, TP53
328.4KLK3, MLH1, CDKN2A, CDK4, ERBB2, TP53
33
Hide members
8.2BRCA1, CDKN2A, CDK4, ERBB2, ESR1, TP53

Compounds for genes affiliated with Female Breast Carcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Female Breast Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 179)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6KLK3
2resveratrol45 60 11 2413.3ERBB2, PGR
3cycloheximide4510.2BRCA1, KLK3
4tamoxifen45 50 29 1113.0CHGA, PGR, ERBB2
5vincristine45 50 1112.0KLK3, BRCA1
6guanine45 11 2411.8ERBB2, BRCA1, KLK3
7adriamycin459.8CDKN2A, CD44, PGR
8estracyt459.6ENO2, KLK3, CHGA
9butyrate459.5BLZF1, KLK3
10megestrol acetate459.4PGR, ERBB2, ESR1, KLK3
115-methylcytosine45 2410.3MLH1, BRCA1, CDKN2A, TP53
12serine459.2KLK3, ERBB2, CD44, CHGB, BRCA1
13gnrh459.2CHGA, CD44, PGR, KLK3, ERBB2
14p002459.2ERBB2, CD44, CHGA, BRCA1, MLH1
15dexamethasone45 50 29 1112.1ENO2, CDK4, CHGB, KLK3, CDKN2A
16biotin45 11 2411.1CDKN2A, ERBB2, CD44, MLH1, KLK3
17etoposide45 50 60 1112.1ERBB2, BRCA1, MLH1, CHGA, KLK3, CD44
18flutamide45 60 1111.0PGR, KLK3, CHGA, ESR1, ENO2
19bromodeoxyuridine459.0ENO2, CDK4, CD44, CHGA, MLH1
20taxane458.9KLK3, ERBB2, ESR1, TP53, PGR
21geldanamycin45 50 60 1111.9TP53, CDK4, ERBB2, PGR, ESR1
22indole-3-carbinol458.9KLK3, CDK4, ESR1, TP53, BRCA1
23folate458.9ERBB2, PGR, CDKN2A, MLH1, BRCA1
24thymidylate458.8CDKN2A, TP53, BRCA1, MLH1, ERBB2, CDK4
25diethylstilbestrol45 29 1110.7KLK3, PGR, ENO2, ESR1
26vitamin d458.7CD44, KLK3, CHGA, CDK4, ERBB2, ESR1
27camptothecin45 60 1110.7KLK3, BRCA1, CDKN2A, MLH1, CDK4, TP53
28n-(4-hydroxyphenyl)retinamide458.7ERBB2, TP53, CDK4, ESR1
295-aza-2deoxycytidine458.5BRCA1, ESR1, MLH1, CDKN2A, PGR, TP53
30methotrexate45 50 1110.5CDKN2A, PGR, BRCA1, ESR1, ENO2, ERBB2
31cyclophosphamide45 50 1110.4CHGA, CD44, PGR, ERBB2, ESR1, BRCA1
32agarose458.3CD44, BLZF1, BRCA1, MLH1, CDKN2A
33formaldehyde45 249.2KLK3, CHGA, CD44, ERBB2, ENO2, BLZF1
345fluorouracil458.1ERBB2, CDK4, BRCA1, MLH1, CDKN2A, PGR
35mg 13245 609.0TP53, ESR1, CDKN2A, BLZF1, BRCA1
36genistein45 29 60 2 11 2413.0CDK4, ERBB2, CDKN2A, PGR, ESR1, BLZF1
37carboplatin45 50 119.8CD44, CDK4, ERBB2, ENO2, TP53, CHGA
38docetaxel45 50 60 1110.7ESR1, TP53, KLK3, BRCA1, CDKN2A, PGR
39steroid457.6BRCA1, CDKN2A, CD44, CDK4, ERBB2, ESR1
40arginine457.6CHGA, CD44, ERBB2, TP53, CDK4, CDKN2A
41paraffin457.6ERBB2, ENO2, ESR1, CDK4, CD44, CHGA
42paclitaxel45 50 119.5TP53, CD44, CDKN2A, CHGA, MLH1, BRCA1
43oxygen45 248.4CHGA, MLH1, ENO2, CDK4, CD44, CDKN2A
44doxorubicin45 50 119.4CD44, CDK4, PGR, ESR1, TP53, ERBB2
45alanine457.3CDK4, ERBB2, CD44, BRCA1, MLH1, CDKN2A
46cisplatin45 50 60 119.9CDK4, CDKN2A, MLH1, BRCA1, ERBB2, ENO2
47testosterone45 60 11 249.6ESR1, ERBB2, PGR, CDK4, CD44, CDKN2A
48retinoic acid45 247.4ENO2, CHGA, PGR, TP53, ESR1, CDK4
49progesterone45 60 29 11 2410.2CDK4, PGR, ERBB2, ENO2, ESR1, TP53
50vegf456.0KLK3, BRCA1, MLH1, CDKN2A, CD44, CDK4

GO Terms for genes affiliated with Female Breast Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.2TP53, ESR1, PGR, CDK4, CDKN2A, BRCA1

Biological processes related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of immature T cell proliferation in thymusGO:0330889.8ERBB2, CDKN2A
2replicative senescenceGO:0903999.4CDKN2A, TP53
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.3TP53, BRCA1
4positive regulation of cell cycle arrestGO:0711589.3TP53, CDKN2A, BRCA1
5cell cycle arrestGO:0070508.9TP53, VASH1, CDKN2A

Molecular functions related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.2CDKN2A, TP53
2enzyme bindingGO:0198998.0TP53, ESR1, PGR, BLZF1, BRCA1
3protein bindingGO:0055156.7BRCA1, MLH1, CHGB, CDKN2A, CD44, CDK4

Products for genes affiliated with Female Breast Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Female Breast Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet