MCID: FML027
MIFTS: 43

Female Breast Carcinoma malady

Cancer diseases category

Aliases & Classifications for Female Breast Carcinoma

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Aliases & Descriptions for Female Breast Carcinoma:

Name: Female Breast Carcinoma 8 10 61
Malignant Neoplasm of Female Breast 61
 
Mammary Carcinoma of Female Breast 8
Female Breast Cancer 8


Classifications:



External Ids:

Disease Ontology8 DOID:7843, DOID:0050671
NCIt39 C2918

Summaries for Female Breast Carcinoma

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Disease Ontology:8 A breast carcinoma that is manifested in the female breast.

MalaCards based summary: Female Breast Carcinoma, also known as malignant neoplasm of female breast, is related to breast cancer and melanoma. An important gene associated with Female Breast Carcinoma is CHGB (chromogranin B (secretogranin 1)), and among its related pathways are Doxorubicin Pathway, Pharmacokinetics and Ovarian Infertility Genes. The compounds megestrol acetate and estracyt have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Related Diseases for Female Breast Carcinoma

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Diseases related to Female Breast Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.2BRCA1, PGR, ESR1, ERBB2, CDK4
2melanoma29.1MLH1, BLZF1, TP53, ENO2, CDKN2A, CDK4
3mismatch repair cancer syndrome10.5MLH1
4somatostatinoma10.5CHGA
5cerebral meningioma10.5PGR
6ewing's family of tumors10.5ENO2
7fallopian tube cancer10.5BRCA1
8subependymal giant cell astrocytoma10.5ENO2
9cystadenoma10.4BRCA1
10actinic keratosis10.4TP53
11endocrine gland cancer10.4MLH1, CHGA
12biliary tract neoplasm10.4MLH1, ERBB2
13alveolar soft-part sarcoma10.4ENO2, MLH1
14gliosarcoma10.4CDK4
15pineocytoma10.4CHGA, ENO2
16lynch syndrome10.4MLH1, BRCA1
17parathyroid adenoma10.3CHGB, CHGA
18merkel cell carcinoma10.3ENO2, CHGA
19sertoli cell tumor10.3PGR, ENO2
20ganglioglioma10.3CHGA, ENO2
21glucagonoma10.3CHGB, CHGA, ENO2
22paraganglioma10.3ENO2, CHGA, CHGB
23medullary thyroid carcinoma, familial10.3CHGB, CHGA, ENO2
24neuroblastoma10.3TP53, ENO2
25rhabdomyosarcoma 2, alveolar10.3ENO2, CDK4
26neuroendocrine tumor10.3CHGB, CHGA, ENO2
27neurofibromatosis10.3MLH1, BLZF1, ENO2
28meningioma, familial10.3PGR, ESR1
29cribriform carcinoma10.3PGR, ESR1
30carcinoid syndrome10.3CHGB, CHGA, ENO2
31progesterone resistance10.3PGR, ESR1
32malignant mixed mullerian tumor10.3PGR, ESR1
33gastrinoma10.3CHGA, ENO2
34leiomyomatosis10.3PGR, ESR1
35adenosarcoma10.3PGR, ESR1
36gallbladder cancer10.3TP53, MLH1
37myoma10.2PGR, ESR1
38pituitary adenoma10.2CHGB, CHGA, CDK4
39endometrial stromal sarcoma10.2PGR, ESR1
40fanconi anemia, complementation group a10.2MLH1, BLZF1, BRCA1
41uterine fibroid10.2PGR, ESR1
42stomach cancer10.2TP53, ERBB2
43prolactinoma10.2ESR1, CHGB, CHGA
44lymphangioleiomyomatosis10.2ESR1, PGR
45angiomyolipoma10.2PGR, ESR1
46ganglioneuroblastoma10.2ENO2, CD44
47pituitary tumors10.2ESR1, CHGB, CHGA
48neutropenia10.2BLZF1, ERBB2, KLK3
49pheochromocytoma10.2ENO2, CHGA, CHGB
50breast disease10.2ERBB2, ESR1, PGR

Graphical network of the top 20 diseases related to Female Breast Carcinoma:



Diseases related to female breast carcinoma

Symptoms for Female Breast Carcinoma

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Drugs & Therapeutics for Female Breast Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Female Breast Carcinoma

Search NIH Clinical Center for Female Breast Carcinoma

Genetic Tests for Female Breast Carcinoma

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Anatomical Context for Female Breast Carcinoma

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MalaCards organs/tissues related to Female Breast Carcinoma:

31
Breast, Lymph node, Prostate

Animal Models for Female Breast Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Female Breast Carcinoma:

35 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4CD44, CDK4, CDKN2A, ESR1, TP53
2MP:00053678.4CDK4, TP53, BRCA1, ESR1, CHGA, CD44
3MP:00053808.1PGR, ESR1, CDK4, CDKN2A, BRCA1, TP53
4MP:00053817.9CDKN2A, CDK4, MLH1, TP53, BRCA1, ESR1
5MP:00053697.8ESR1, TP53, BRCA1, CD44, CDK4, CDKN2A
6MP:00053887.8ESR1, CD44, CDKN2A, ENO2, ERBB2, TP53
7MP:00053717.7TP53, PGR, ERBB2, BLZF1, CD44, ESR1
8MP:00053977.7CD44, CDK4, CDKN2A, ESR1, PGR, BRCA1
9MP:00020067.6CD44, CDK4, CDKN2A, ERBB2, ESR1, PGR
10MP:00107717.6ERBB2, CD44, MLH1, CDK4, CDKN2A, ESR1
11MP:00053787.6CHGA, TP53, ERBB2, CDKN2A, CDK4, CD44
12MP:00053877.5CD44, CDKN2A, ESR1, PGR, BRCA1, TP53
13MP:00053857.4CDK4, PGR, CD44, VASH1, CHGA, ESR1
14MP:00053897.4CHGA, ERBB2, CDKN2A, CDK4, ESR1, PGR
15MP:00053907.3CDKN2A, CD44, ERBB2, ESR1, BRCA1, BLZF1
16MP:00036317.2CD44, CDK4, BRCA1, ESR1, CHGB, ERBB2
17MP:00053867.2CD44, CDK4, ENO2, ERBB2, ESR1, PGR
18MP:00107687.2CD44, CDKN2A, CDK4, CHGA, ESR1, PGR
19MP:00053797.2CHGA, MLH1, TP53, BRCA1, PGR, CHGB
20MP:00053767.1ESR1, PGR, BRCA1, TP53, CHGB, CHGA
21MP:00053847.1ENO2, MLH1, TP53, CDK4, BRCA1, ESR1

Publications for Female Breast Carcinoma

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Articles related to Female Breast Carcinoma:

(show all 28)
idTitleAuthorsYear
1
Risk factors of female breast carcinoma: a case control study at Puducherry. (23713049)
2013
2
Intratumoral estrogen concentration and expression of estrogen-induced genes in male breast carcinoma: comparison with female breast carcinoma. (23096432)
2013
3
Prevalence of known prognostic factors in female breast carcinoma including oestrogen receptor, progesterone receptor and Her-2/neu status--a study in a tertiary care centre. (23936949)
2012
4
Prostate-specific antigen and hormone receptor expression in male and female breast carcinoma. (20863373)
2010
5
Age related association of Her-2/neu with prognostic markers in female breast carcinoma. (20810050)
2010
6
Inter- and intra-ethnic differences for female breast carcinoma incidence in the continental United States and in the state of Hawaii. (16322891)
2006
7
Correlation of her-2/neu gene amplification with other prognostic and predictive factors in female breast carcinoma. (15982396)
2005
8
The role of CD44v3 expression in female breast carcinomas. (14998292)
2003
9
Status of HER-2 in male and female breast carcinoma. (11720677)
2001
10
Female breast carcinomas: nuclear and cytoplasmic proteins versus steroid receptors. (10756981)
2000
11
Germline BRCA1 and HMLH1 mutations in a family with male and female breast carcinoma. (10709098)
2000
12
Low-stage carcinoma of the male breast. A histologic, immunohistochemical, and flow cytometric comparison with localized female breast carcinoma. (9894455)
1999
13
Time trend of female breast carcinoma in situ by race and histology in Connecticut, USA. (9071907)
1997
14
Allium vegetable consumption, garlic supplement intake, and female breast carcinoma incidence. (7749142)
1995
15
Analysis of MTS1/CDK4 in female breast carcinomas. (7889533)
1995
16
Argyrophilia and granin (chromogranin/secretogranin) expression in female breast carcinomas. Their relationship to survival and other disease parameters. (1376022)
1992
17
Expression of tumour markers CA50, CEA and TPA in female breast carcinoma as related to histopathological findings and survival. (1567186)
1992
18
Hormone receptor status and mitotic activity as risk factors for recurrence and death in female breast carcinoma. (1768039)
1991
19
Regional lymph node reactions related to hormone receptor status in female breast carcinoma. (4004508)
1985
20
Hormone receptor levels related to histological parameters of tumor-host relationships in female breast carcinoma. (6287111)
1982
21
Histochemically demonstrable enzyme activities and their independence of the hormone receptor content in female breast carcinoma. (6298092)
1982
22
Paracortical activity in the lymph nodes draining female breast carcinoma. (311901)
1979
23
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. V. PHENOL,4,4'-(DL-1,2-DIETHYL-ETHYLENE)DI- AND ANDROST-4-EN-3-ONE, 9-CHLORO-11-BETA, 17-BETA-DIHYDROXY-17-METHYL-. (14278041)
1965
24
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. IV. 17-BETA-AMINO-5-ALPHA-ANDROSTAN-11-BETA-OL. (14176991)
1964
25
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. III. ANDROST-4-EN-3-ONE-2ALPHA,17BETA-DIHYDROXY DIPROPIONATE AND ANDROST-4-EN-3-ONE-16ALPHA, 17BETA-DIHYDROXY DIPROPIONATE. (14050008)
1963
26
Hormonal therapy of metastatic female breast carcinoma. II. 2alpha-Methyl dihydrotestosterone propionate. (13706491)
1961
27
The present controversy in the treatment of female breast carcinoma. (13665202)
1959
28
Hormonal therapy of metastatic female breast carcinoma. I. 9 alpha-Bromo-11-ketoprogesterone. (13663018)
1959

Variations for Female Breast Carcinoma

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Expression for genes affiliated with Female Breast Carcinoma

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Search GEO for disease gene expression data for Female Breast Carcinoma.

Pathways for genes affiliated with Female Breast Carcinoma

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Pathways related to Female Breast Carcinoma according to GeneCards Suite gene sharing:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7MLH1, TP53
29.7CDK4, PGR, MLH1
39.6TP53, BRCA1
49.6BRCA1, TP53
59.6BRCA1, TP53
69.6BRCA1, TP53
7
Show member pathways
9.6CDK4, BRCA1, MLH1
8
Show member pathways
Cell cycle ESR1 regulation of G1 S transition59
Immune response MIF JAB1 signaling59
Cell cycle Cell cycle generic schema 59
9.5PGR, CDK4, ESR1
9
Show member pathways
9.5TP53, CDKN2A
109.5TP53, CDKN2A
11
Show member pathways
Signal transduction PTEN pathway59
9.4ERBB2, TP53, MLH1
12
Show member pathways
FOXA transcription factor networks36
9.4ESR1, BRCA1, KLK3
13
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation59
9.4CDKN2A, CDK4, BRCA1
149.4BRCA1, MLH1, TP53
159.4CDK4, TP53, ERBB2
169.3BRCA1, TP53, CDK4
17
Show member pathways
9.3CDK4, BRCA1, TP53
189.3BRCA1, TP53, CDK4
19
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
9.3ERBB2, TP53, ESR1
20
Show member pathways
9.2CDK4, CDKN2A, TP53
21
Show member pathways
Cell cycle36
9.2CDK4, TP53, CDKN2A
229.2CDKN2A, TP53, CDK4
23
Show member pathways
9.2CDKN2A, CDK4, TP53
249.2CDK4, CDKN2A, TP53
259.2TP53, CDKN2A, CDK4
269.2CDK4, TP53, CDKN2A
279.1CD44, TP53, CDKN2A
28
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.0TP53, CDK4, BRCA1, KLK3
299.0TP53, CDK4, ESR1, BRCA1
30
Show member pathways
9.0TP53, BRCA1, ESR1, CDK4
31
Show member pathways
8.9ERBB2, CDKN2A, CDK4, TP53
328.9ERBB2, ESR1, TP53, CD44
33
Show member pathways
DNA damage response36
8.9CDK4, CDKN2A, BRCA1, TP53
348.9TP53, ESR1, CDK4, CD44
35
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
8.8CD44, ERBB2, CDKN2A, TP53
368.7ESR1, BRCA1, TP53, CDK4, ERBB2
37
Show member pathways
8.6CDKN2A, CDK4, BRCA1, TP53, MLH1
388.5TP53, ERBB2, CDKN2A, CD44, BRCA1
398.3CDK4, CDKN2A, KLK3, TP53, ERBB2, MLH1
40
Show member pathways
Signaling Pathways in Glioblastoma36
8.3CDK4, TP53, BRCA1, ERBB2, KLK3, CDKN2A
41
Show member pathways
8.2ERBB2, TP53, CDK4, BRCA1, CDKN2A, ESR1
42
Show member pathways
8.2TP53, BRCA1, ESR1, CDKN2A, ERBB2, CDK4
43
Show member pathways
8.1TP53, CDK4, BLZF1, BRCA1, CDKN2A

Compounds for genes affiliated with Female Breast Carcinoma

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Compounds related to Female Breast Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 215)
idCompoundScoreTop Affiliating Genes
1megestrol acetate449.5PGR, ERBB2, KLK3, ESR1
2estracyt449.5CHGA, ENO2, KLK3
35-methylcytosine44 2410.2MLH1, CDKN2A, BRCA1, TP53
4p002449.2CHGA, BRCA1, MLH1, ERBB2, CD44
5flutamide44 60 1111.1PGR, ENO2, KLK3, ESR1, CHGA
6taxane449.1ERBB2, KLK3, ESR1, PGR, TP53
7geldanamycin44 50 60 1112.0PGR, ESR1, TP53, CDK4, ERBB2
8biotin44 24 1111.0CD44, CDKN2A, KLK3, MLH1, ERBB2
9indole-3-carbinol449.0KLK3, ESR1, BRCA1, CDK4, TP53
10folate448.9BRCA1, PGR, CDKN2A, ERBB2, MLH1
11bromodeoxyuridine448.9CHGA, MLH1, CDK4, ENO2, CD44
12gnrh448.9PGR, CHGA, ERBB2, CD44, ESR1, KLK3
13resveratrol44 60 24 1111.8BRCA1, PGR, ESR1, ERBB2, CDK4, TP53
14thymidylate448.8CDKN2A, CDK4, ERBB2, BRCA1, TP53, MLH1
15vitamin d448.7KLK3, CD44, CHGA, ESR1, CDK4, ERBB2
16camptothecin44 60 1110.7CDKN2A, BRCA1, CDK4, KLK3, MLH1, TP53
17diethylstilbestrol44 28 1110.7PGR, KLK3, ENO2, ESR1
185-aza-2deoxycytidine448.6MLH1, BRCA1, CDKN2A, ESR1, TP53, PGR
19vincristine44 50 1110.6CDKN2A, TP53, BRCA1, KLK3, CD44
20adriamycin448.6CD44, ERBB2, BRCA1, TP53, CDKN2A, PGR
21guanine44 24 1110.6TP53, CHGA, ERBB2, KLK3, ENO2, BRCA1
22methotrexate50 44 1110.6PGR, ENO2, CDKN2A, ERBB2, ESR1, BRCA1
23cyclophosphamide44 50 1110.5PGR, ERBB2, ESR1, CHGA, BRCA1, TP53
24tamoxifen44 50 28 1111.4PGR, BRCA1, TP53, ESR1, CHGA, CD44
25formaldehyde44 249.2ENO2, KLK3, ERBB2, CD44, CHGA, BLZF1
265fluorouracil448.1MLH1, CDK4, PGR, CDKN2A, ERBB2, TP53
27agarose448.1CDKN2A, MLH1, BLZF1, CD44, BRCA1
28mg 13244 609.0BRCA1, ESR1, CDKN2A, BLZF1, TP53
29etoposide44 50 60 1111.0CD44, MLH1, TP53, BRCA1, KLK3, ERBB2
30genistein44 28 60 1 24 1113.0PGR, CDK4, BLZF1, CDKN2A, BRCA1, ESR1
31butyrate447.9BLZF1, TP53, KLK3, CDKN2A, CDK4, CD44
32dexamethasone44 50 28 1110.8CD44, CDK4, CDKN2A, ENO2, KLK3, CHGA
33docetaxel44 50 60 1110.8ERBB2, CDKN2A, PGR, BRCA1, TP53, ENO2
34carboplatin44 50 119.7CDK4, CD44, ENO2, KLK3, ERBB2, MLH1
35arginine447.5CDKN2A, CHGA, ERBB2, MLH1, CD44, TP53
36doxorubicin44 50 119.4CDK4, CDKN2A, KLK3, ERBB2, ESR1, PGR
37oxygen44 248.4CDKN2A, CD44, CDK4, ENO2, CHGA, MLH1
38alanine447.2ENO2, CDKN2A, PGR, CDK4, CD44, MLH1
39paclitaxel44 50 119.1MLH1, TP53, BRCA1, PGR, ESR1, CHGA
40tyrosine447.1ENO2, ERBB2, BRCA1, BLZF1, CHGA, MLH1
41serine446.9CD44, CHGB, CHGA, BRCA1, ERBB2, KLK3
42steroid446.8CD44, CDK4, CDKN2A, KLK3, ERBB2, CHGA
43paraffin446.6KLK3, CHGA, ESR1, PGR, BRCA1, TP53
44cycloheximide446.6KLK3, CDKN2A, CDK4, ERBB2, CHGA, ESR1
45testosterone44 60 24 119.5CDK4, BRCA1, PGR, CDKN2A, ESR1, CHGA
46cisplatin44 50 60 119.4CHGA, ERBB2, ENO2, CDKN2A, CDK4, CD44
47retinoic acid44 247.4CHGA, MLH1, CDKN2A, CDK4, CD44, ENO2
48progesterone44 28 60 24 1110.1CD44, CDK4, CDKN2A, ENO2, ERBB2, CHGA
49vegf446.0CD44, CDK4, CDKN2A, ENO2, KLK3, ERBB2
50estrogen445.6CD44, CDK4, CDKN2A, ENO2, KLK3, ERBB2

GO Terms for genes affiliated with Female Breast Carcinoma

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Cellular components related to Female Breast Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166049.5CDKN2A, TP53
2nucleoplasmGO:00056547.9CDK4, CDKN2A, ESR1, PGR, BRCA1, TP53

Biological processes related to Female Breast Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of immature T cell proliferation in thymusGO:00330889.8CDKN2A, ERBB2
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.5TP53, BRCA1
3replicative senescenceGO:00903999.5CDKN2A, TP53
4positive regulation of cell cycle arrestGO:00711589.3CDKN2A, BRCA1, TP53
5regulation of apoptotic processGO:00429819.3ESR1, BRCA1, TP53
6cell cycle arrestGO:00070508.6CDKN2A, VASH1, TP53

Molecular functions related to Female Breast Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:00054969.8ESR1, PGR
2MDM2/MDM4 family protein bindingGO:00973719.4TP53, CDKN2A
3ubiquitin protein ligase bindingGO:00316258.5BRCA1, TP53, BLZF1
4enzyme bindingGO:00198998.2ESR1, PGR, BRCA1, TP53, BLZF1
5protein bindingGO:00055156.7PGR, BRCA1, TP53, MLH1, ESR1, CHGB

Sources for Female Breast Carcinoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet