MCID: FML027
MIFTS: 50

Female Breast Carcinoma malady

Cancer diseases category
Download this MalaCard

Summaries for Female Breast Carcinoma

About this section
Sources:
8Disease Ontology, 33MalaCards
See all sources

Fully expand this MalaCard
Disease Ontology:8 A breast carcinoma that is manifested in the female breast.

MalaCards: Female Breast Carcinoma, also known as mammary carcinoma of female breast, is related to breast cancer and male breast cancer. An important gene associated with Female Breast Carcinoma is CHGB (chromogranin B (secretogranin 1)), and among its related pathways are Doxorubicin Pathway, Pharmacokinetics and Ovarian Infertility Genes. The compounds megestrol acetate and estracyt have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Female Breast Carcinoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

female breast carcinoma 8 10 62
mammary carcinoma of female breast 8
female breast cancer 8


External Ids:

Disease Ontology8 DOID:7843, DOID:0050671
NCIt40 C2918

Related Diseases for Female Breast Carcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Female Breast Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.3BRCA1, PGR, ESR1, ERBB2, CDK4
2male breast cancer30.8ERBB2, ESR1, PGR, BRCA1
3melanoma29.8MLH1, BLZF1, TP53, ENO2, CDKN2A, CDK4
4turcot syndrome10.1MLH1
5somatostatinoma10.1CHGA
6cerebral meningioma10.1PGR
7cerebral primitive neuroectodermal tumor10.1ENO2
8fallopian tube cancer10.1BRCA1
9subependymal giant cell astrocytoma10.1ENO2
10cystadenoma10.1BRCA1
11actinic keratosis10.1TP53
12endocrine gland cancer10.1MLH1, CHGA
13biliary tract neoplasm10.1MLH1, ERBB2
14breast carcinoma in situ10.1
15prostatitis10.1
16alveolar soft part sarcoma10.1ENO2, MLH1
17gliosarcoma10.1CDK4
18pineocytoma10.1CHGA, ENO2
19lynch syndrome10.1MLH1, BRCA1
20parathyroid adenoma10.1CHGB, CHGA
21merkel cell carcinoma10.1ENO2, CHGA
22sertoli cell tumor10.1PGR, ENO2
23ganglioglioma10.1CHGA, ENO2
24glucagonoma10.1CHGB, CHGA, ENO2
25paraganglioma10.1ENO2, CHGA, CHGB
26thyroid medullary carcinoma10.1CHGB, CHGA, ENO2
27neuroblastoma10.1TP53, ENO2
28alveolar rhabdomyosarcoma10.1ENO2, CDK4
29neuroendocrine tumor10.1CHGB, CHGA, ENO2
30neurofibromatosis10.1MLH1, BLZF1, ENO2
31meningioma10.1PGR, ESR1
32cribriform carcinoma10.1PGR, ESR1
33carcinoid syndrome10.1CHGB, CHGA, ENO2
34progesterone resistance10.1PGR, ESR1
35malignant mixed mullerian tumor10.1PGR, ESR1
36gastrinoma10.1CHGA, ENO2
37leiomyomatosis10.1PGR, ESR1
38adenosarcoma10.1PGR, ESR1
39gallbladder cancer10.1TP53, MLH1
40myoma10.1PGR, ESR1
41pituitary adenoma10.1CHGB, CHGA, CDK4
42endometrial stromal sarcoma10.1PGR, ESR1
43fanconi's anemia10.1MLH1, BLZF1, BRCA1
44uterine fibroid10.1PGR, ESR1
45stomach cancer10.1TP53, ERBB2
46prolactinoma10.1ESR1, CHGB, CHGA
47lymphangioleiomyomatosis10.1ESR1, PGR
48angiomyolipoma10.1PGR, ESR1
49ganglioneuroblastoma10.1ENO2, CD44
50pituitary tumors10.0ESR1, CHGB, CHGA

Graphical network of the top 20 diseases related to Female Breast Carcinoma:



Diseases related to female breast carcinoma

Symptoms for Female Breast Carcinoma

About this section

Drugs & Therapeutics for Female Breast Carcinoma

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Female Breast Carcinoma

Search NIH Clinical Center for Female Breast Carcinoma

Genetic Tests for Female Breast Carcinoma

About this section

Anatomical Context for Female Breast Carcinoma

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Female Breast Carcinoma:

33
Breast, Lymph node, Prostate

Animal Models for Female Breast Carcinoma or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Female Breast Carcinoma:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4CD44, CDK4, CDKN2A, ESR1, TP53
2MP:00053678.4TP53, BRCA1, ESR1, CHGA, CDK4, CD44
3MP:00053808.1TP53, BRCA1, PGR, ESR1, ERBB2, CDKN2A
4MP:00053817.9MLH1, TP53, BRCA1, ESR1, ERBB2, CDKN2A
5MP:00053697.8TP53, BRCA1, PGR, ESR1, ERBB2, CDKN2A
6MP:00053887.8TP53, BRCA1, ESR1, ERBB2, ENO2, CDKN2A
7MP:00053717.7BLZF1, TP53, BRCA1, PGR, ESR1, ERBB2
8MP:00053977.7TP53, BRCA1, PGR, ESR1, CDKN2A, CDK4
9MP:00020067.6MLH1, TP53, BRCA1, PGR, ESR1, ERBB2
10MP:00107717.6MLH1, TP53, BRCA1, PGR, ESR1, ERBB2
11MP:00053787.6TP53, BRCA1, ESR1, CHGA, ERBB2, CDKN2A
12MP:00053877.5TP53, BRCA1, PGR, ESR1, CDKN2A, CDK4
13MP:00053857.4TP53, BRCA1, PGR, ESR1, CHGA, VASH1
14MP:00053897.4MLH1, TP53, BRCA1, PGR, ESR1, CHGA
15MP:00053907.3BLZF1, TP53, BRCA1, PGR, ESR1, ERBB2
16MP:00036317.2TP53, BRCA1, ESR1, CHGB, ERBB2, ENO2
17MP:00053867.2TP53, BRCA1, PGR, ESR1, ERBB2, ENO2
18MP:00107687.2MLH1, TP53, BRCA1, PGR, ESR1, CHGA
19MP:00053797.2CD44, MLH1, TP53, BRCA1, PGR, ESR1
20MP:00053767.1MLH1, TP53, BRCA1, PGR, ESR1, CHGB
21MP:00053847.1MLH1, TP53, BRCA1, PGR, ESR1, ERBB2

Publications for Female Breast Carcinoma

About this section
Sources:
52PubMed
See all sources

Articles related to Female Breast Carcinoma:

(show all 28)
idTitleAuthorsYear
1
Risk factors of female breast carcinoma: a case control study at Puducherry. (23713049)
2013
2
Intratumoral estrogen concentration and expression of estrogen-induced genes in male breast carcinoma: comparison with female breast carcinoma. (23096432)
2013
3
Prevalence of known prognostic factors in female breast carcinoma including oestrogen receptor, progesterone receptor and Her-2/neu status--a study in a tertiary care centre. (23936949)
2012
4
Prostate-specific antigen and hormone receptor expression in male and female breast carcinoma. (20863373)
2010
5
Age related association of Her-2/neu with prognostic markers in female breast carcinoma. (20810050)
2010
6
Inter- and intra-ethnic differences for female breast carcinoma incidence in the continental United States and in the state of Hawaii. (16322891)
2006
7
Correlation of her-2/neu gene amplification with other prognostic and predictive factors in female breast carcinoma. (15982396)
2005
8
The role of CD44v3 expression in female breast carcinomas. (14998292)
2003
9
Status of HER-2 in male and female breast carcinoma. (11720677)
2001
10
Female breast carcinomas: nuclear and cytoplasmic proteins versus steroid receptors. (10756981)
2000
11
Germline BRCA1 and HMLH1 mutations in a family with male and female breast carcinoma. (10709098)
2000
12
Low-stage carcinoma of the male breast. A histologic, immunohistochemical, and flow cytometric comparison with localized female breast carcinoma. (9894455)
1999
13
Time trend of female breast carcinoma in situ by race and histology in Connecticut, USA. (9071907)
1997
14
Allium vegetable consumption, garlic supplement intake, and female breast carcinoma incidence. (7749142)
1995
15
Analysis of MTS1/CDK4 in female breast carcinomas. (7889533)
1995
16
Argyrophilia and granin (chromogranin/secretogranin) expression in female breast carcinomas. Their relationship to survival and other disease parameters. (1376022)
1992
17
Expression of tumour markers CA50, CEA and TPA in female breast carcinoma as related to histopathological findings and survival. (1567186)
1992
18
Hormone receptor status and mitotic activity as risk factors for recurrence and death in female breast carcinoma. (1768039)
1991
19
Regional lymph node reactions related to hormone receptor status in female breast carcinoma. (4004508)
1985
20
Hormone receptor levels related to histological parameters of tumor-host relationships in female breast carcinoma. (6287111)
1982
21
Histochemically demonstrable enzyme activities and their independence of the hormone receptor content in female breast carcinoma. (6298092)
1982
22
Paracortical activity in the lymph nodes draining female breast carcinoma. (311901)
1979
23
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. V. PHENOL,4,4'-(DL-1,2-DIETHYL-ETHYLENE)DI- AND ANDROST-4-EN-3-ONE, 9-CHLORO-11-BETA, 17-BETA-DIHYDROXY-17-METHYL-. (14278041)
1965
24
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. IV. 17-BETA-AMINO-5-ALPHA-ANDROSTAN-11-BETA-OL. (14176991)
1964
25
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. III. ANDROST-4-EN-3-ONE-2ALPHA,17BETA-DIHYDROXY DIPROPIONATE AND ANDROST-4-EN-3-ONE-16ALPHA, 17BETA-DIHYDROXY DIPROPIONATE. (14050008)
1963
26
Hormonal therapy of metastatic female breast carcinoma. II. 2alpha-Methyl dihydrotestosterone propionate. (13706491)
1961
27
The present controversy in the treatment of female breast carcinoma. (13665202)
1959
28
Hormonal therapy of metastatic female breast carcinoma. I. 9 alpha-Bromo-11-ketoprogesterone. (13663018)
1959

Variations for Female Breast Carcinoma

About this section

Expression for genes affiliated with Female Breast Carcinoma

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Female Breast Carcinoma

Search GEO for disease gene expression data for Female Breast Carcinoma.

Pathways for genes affiliated with Female Breast Carcinoma

About this section
Sources:
50PathCards, 51PharmGKB, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 12EMD Millipore, 55Reactome, 30KEGG, 54R&D Systems, 57SinoBiological, 5Cell Signaling Technology
See all sources

Pathways related to Female Breast Carcinoma according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7MLH1, TP53
29.7CDK4, PGR, MLH1
39.6TP53, BRCA1
49.6BRCA1, TP53
59.6BRCA1, TP53
69.6BRCA1, TP53
7
Show member pathways
9.6CDK4, BRCA1, MLH1
8
Show member pathways
9.6CDK4, BRCA1, MLH1
9
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.5PGR, CDK4, ESR1
10
Show member pathways
9.5TP53, CDKN2A
119.5TP53, CDKN2A
12
Show member pathways
Signal transduction PTEN pathway60
9.4ERBB2, TP53, MLH1
13
Show member pathways
FOXA transcription factor networks38
9.4ESR1, BRCA1, KLK3
14
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.4CDKN2A, CDK4, BRCA1
159.4BRCA1, MLH1, TP53
169.4CDK4, TP53, ERBB2
179.3BRCA1, TP53, CDK4
18
Show member pathways
9.3CDK4, BRCA1, TP53
199.3BRCA1, TP53, CDK4
20
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.3ERBB2, TP53, ESR1
21
Show member pathways
9.2CDK4, CDKN2A, TP53
22
Show member pathways
Cell cycle38
9.2CDK4, TP53, CDKN2A
239.2CDKN2A, TP53, CDK4
24
Show member pathways
9.2CDKN2A, CDK4, TP53
259.2CDK4, CDKN2A, TP53
269.2TP53, CDKN2A, CDK4
279.2CDK4, TP53, CDKN2A
289.1CD44, TP53, CDKN2A
29
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.0TP53, CDK4, BRCA1, KLK3
309.0TP53, CDK4, ESR1, BRCA1
31
Show member pathways
9.0TP53, BRCA1, ESR1, CDK4
32
Show member pathways
8.9ERBB2, CDKN2A, CDK4, TP53
338.9ERBB2, ESR1, TP53, CD44
34
Show member pathways
DNA damage response38
8.9CDK4, CDKN2A, BRCA1, TP53
358.9TP53, ESR1, CDK4, CD44
36
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
8.8CD44, ERBB2, CDKN2A, TP53
378.7ESR1, BRCA1, TP53, CDK4, ERBB2
38
Show member pathways
8.6CDKN2A, CDK4, BRCA1, TP53, MLH1
398.5TP53, ERBB2, CDKN2A, CD44, BRCA1
408.3CDK4, CDKN2A, KLK3, TP53, ERBB2, MLH1
41
Show member pathways
Signaling Pathways in Glioblastoma38
8.3CDK4, TP53, BRCA1, ERBB2, KLK3, CDKN2A
42
Show member pathways
8.2ERBB2, TP53, CDK4, BRCA1, CDKN2A, ESR1
43
Show member pathways
8.2TP53, BRCA1, ESR1, CDKN2A, ERBB2, CDK4
44
Show member pathways
8.1TP53, CDK4, BLZF1, BRCA1, CDKN2A

Compounds for genes affiliated with Female Breast Carcinoma

About this section
Sources:
45Novoseek, 24HMDB, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 29IUPHAR, 3BitterDB
See all sources

Compounds related to Female Breast Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 215)
idCompoundScoreTop Affiliating Genes
1megestrol acetate459.5PGR, ERBB2, KLK3, ESR1
2estracyt459.5CHGA, ENO2, KLK3
35-methylcytosine45 2410.2MLH1, CDKN2A, BRCA1, TP53
4p002459.2CHGA, BRCA1, MLH1, ERBB2, CD44
5flutamide45 61 1111.1PGR, ENO2, KLK3, ESR1, CHGA
6taxane459.1ERBB2, KLK3, ESR1, PGR, TP53
7geldanamycin45 51 61 1112.0PGR, ESR1, TP53, CDK4, ERBB2
8biotin45 24 1111.0CD44, CDKN2A, KLK3, MLH1, ERBB2
9indole-3-carbinol459.0KLK3, ESR1, BRCA1, CDK4, TP53
10folate458.9BRCA1, PGR, CDKN2A, ERBB2, MLH1
11bromodeoxyuridine458.9CHGA, MLH1, CDK4, ENO2, CD44
12gnrh458.9PGR, CHGA, ERBB2, CD44, ESR1, KLK3
13resveratrol45 61 24 1111.8BRCA1, PGR, ESR1, ERBB2, CDK4, TP53
14thymidylate458.8CDKN2A, CDK4, ERBB2, BRCA1, TP53, MLH1
15vitamin d458.7KLK3, CD44, CHGA, ESR1, CDK4, ERBB2
16camptothecin45 61 1110.7CDKN2A, BRCA1, CDK4, KLK3, MLH1, TP53
17diethylstilbestrol45 29 1110.7PGR, KLK3, ENO2, ESR1
185-aza-2deoxycytidine458.6MLH1, BRCA1, CDKN2A, ESR1, TP53, PGR
19vincristine45 51 1110.6CDKN2A, TP53, BRCA1, KLK3, CD44
20adriamycin458.6CD44, ERBB2, BRCA1, TP53, CDKN2A, PGR
21guanine45 24 1110.6TP53, CHGA, ERBB2, KLK3, ENO2, BRCA1
22methotrexate51 45 1110.6PGR, ENO2, CDKN2A, ERBB2, ESR1, BRCA1
23cyclophosphamide45 51 1110.5PGR, ERBB2, ESR1, CHGA, BRCA1, TP53
24tamoxifen45 51 29 1111.4PGR, BRCA1, TP53, ESR1, CHGA, CD44
25formaldehyde45 249.2ENO2, KLK3, ERBB2, CD44, CHGA, BLZF1
265fluorouracil458.1MLH1, CDK4, PGR, CDKN2A, ERBB2, TP53
27agarose458.1CDKN2A, MLH1, BLZF1, CD44, BRCA1
28mg 13245 619.0BRCA1, ESR1, CDKN2A, BLZF1, TP53
29etoposide45 51 61 1111.0CD44, MLH1, TP53, BRCA1, KLK3, ERBB2
30genistein45 29 61 3 24 1113.0PGR, CDK4, BLZF1, CDKN2A, BRCA1, ESR1
31butyrate457.9BLZF1, TP53, KLK3, CDKN2A, CDK4, CD44
32dexamethasone45 51 29 1110.8CD44, CDK4, CDKN2A, ENO2, KLK3, CHGA
33docetaxel45 51 61 1110.8ERBB2, CDKN2A, PGR, BRCA1, TP53, ENO2
34carboplatin45 51 119.7CDK4, CD44, ENO2, KLK3, ERBB2, MLH1
35arginine457.5CDKN2A, CHGA, ERBB2, MLH1, CD44, TP53
36doxorubicin45 51 119.4CDK4, CDKN2A, KLK3, ERBB2, ESR1, PGR
37oxygen45 248.4CDKN2A, CD44, CDK4, ENO2, CHGA, MLH1
38alanine457.2ENO2, CDKN2A, PGR, CDK4, CD44, MLH1
39paclitaxel45 51 119.1MLH1, TP53, BRCA1, PGR, ESR1, CHGA
40tyrosine457.1ENO2, ERBB2, BRCA1, BLZF1, CHGA, MLH1
41serine456.9CD44, CHGB, CHGA, BRCA1, ERBB2, KLK3
42steroid456.8CD44, CDK4, CDKN2A, KLK3, ERBB2, CHGA
43paraffin456.6KLK3, CHGA, ESR1, PGR, BRCA1, TP53
44cycloheximide456.6KLK3, CDKN2A, CDK4, ERBB2, CHGA, ESR1
45testosterone45 61 24 119.5CDK4, BRCA1, PGR, CDKN2A, ESR1, CHGA
46cisplatin45 51 61 119.4CHGA, ERBB2, ENO2, CDKN2A, CDK4, CD44
47retinoic acid45 247.4CHGA, MLH1, CDKN2A, CDK4, CD44, ENO2
48progesterone45 29 61 24 1110.1CD44, CDK4, CDKN2A, ENO2, ERBB2, CHGA
49vegf456.0CD44, CDK4, CDKN2A, ENO2, KLK3, ERBB2
50estrogen455.6CD44, CDK4, CDKN2A, ENO2, KLK3, ERBB2

GO Terms for genes affiliated with Female Breast Carcinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.5CDKN2A, TP53
2nucleoplasmGO:0056547.9CDK4, CDKN2A, ESR1, PGR, BRCA1, TP53

Biological processes related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of immature T cell proliferation in thymusGO:0330889.8CDKN2A, ERBB2
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.5TP53, BRCA1
3replicative senescenceGO:0903999.5CDKN2A, TP53
4positive regulation of cell cycle arrestGO:0711589.3CDKN2A, BRCA1, TP53
5regulation of apoptotic processGO:0429819.3ESR1, BRCA1, TP53
6cell cycle arrestGO:0070508.6CDKN2A, VASH1, TP53

Molecular functions related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.8ESR1, PGR
2MDM2/MDM4 family protein bindingGO:0973719.4TP53, CDKN2A
3ubiquitin protein ligase bindingGO:0316258.5BRCA1, TP53, BLZF1
4enzyme bindingGO:0198998.2ESR1, PGR, BRCA1, TP53, BLZF1
5protein bindingGO:0055156.7PGR, BRCA1, TP53, MLH1, ESR1, CHGB

Products for genes affiliated with Female Breast Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Female Breast Carcinoma

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet