MCID: FML027
MIFTS: 50

Female Breast Carcinoma malady

Cancer diseases category
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Summaries for Female Breast Carcinoma

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Disease Ontology:8 A breast carcinoma that is manifested in the female breast.

MalaCards based summary: Female Breast Carcinoma, also known as mammary carcinoma of female breast, is related to breast cancer and male breast cancer. An important gene associated with Female Breast Carcinoma is CHGB (chromogranin B (secretogranin 1)), and among its related pathways are Doxorubicin Pathway, Pharmacokinetics and Ovarian Infertility Genes. The compounds megestrol acetate and estracyt have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Female Breast Carcinoma

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Female Breast Carcinoma, Aliases & Descriptions:

Name: Female Breast Carcinoma 8 10 62
Mammary Carcinoma of Female Breast 8 62
 
Female Breast Cancer 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:7843, DOID:0050671
NCIt39 C2918

Related Diseases for Female Breast Carcinoma

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Diseases related to Female Breast Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.2BRCA1, PGR, ESR1, ERBB2, CDK4
2male breast cancer30.9ERBB2, ESR1, PGR, BRCA1
3melanoma29.1MLH1, BLZF1, TP53, ENO2, CDKN2A, CDK4
4turcot syndrome10.5MLH1
5somatostatinoma10.5CHGA
6cerebral meningioma10.5PGR
7cerebral primitive neuroectodermal tumor10.5ENO2
8fallopian tube cancer10.5BRCA1
9subependymal giant cell astrocytoma10.5ENO2
10cystadenoma10.4BRCA1
11actinic keratosis10.4TP53
12endocrine gland cancer10.4MLH1, CHGA
13biliary tract neoplasm10.4MLH1, ERBB2
14alveolar soft part sarcoma10.4ENO2, MLH1
15gliosarcoma10.4CDK4
16pineocytoma10.4CHGA, ENO2
17lynch syndrome10.4MLH1, BRCA1
18parathyroid adenoma10.4CHGB, CHGA
19merkel cell carcinoma10.4ENO2, CHGA
20sertoli cell tumor10.4PGR, ENO2
21ganglioglioma10.3CHGA, ENO2
22glucagonoma10.3CHGB, CHGA, ENO2
23paraganglioma10.3ENO2, CHGA, CHGB
24thyroid medullary carcinoma10.3CHGB, CHGA, ENO2
25neuroblastoma10.3TP53, ENO2
26alveolar rhabdomyosarcoma10.3ENO2, CDK4
27neuroendocrine tumor10.3CHGB, CHGA, ENO2
28neurofibromatosis10.3MLH1, BLZF1, ENO2
29meningioma10.3PGR, ESR1
30cribriform carcinoma10.3PGR, ESR1
31carcinoid syndrome10.3CHGB, CHGA, ENO2
32progesterone resistance10.3PGR, ESR1
33malignant mixed mullerian tumor10.3PGR, ESR1
34gastrinoma10.3CHGA, ENO2
35leiomyomatosis10.3PGR, ESR1
36adenosarcoma10.3PGR, ESR1
37gallbladder cancer10.3TP53, MLH1
38myoma10.3PGR, ESR1
39pituitary adenoma10.3CHGB, CHGA, CDK4
40endometrial stromal sarcoma10.3PGR, ESR1
41fanconi's anemia10.2MLH1, BLZF1, BRCA1
42uterine fibroid10.2PGR, ESR1
43stomach cancer10.2TP53, ERBB2
44prolactinoma10.2ESR1, CHGB, CHGA
45lymphangioleiomyomatosis10.2ESR1, PGR
46angiomyolipoma10.2PGR, ESR1
47ganglioneuroblastoma10.2ENO2, CD44
48pituitary tumors10.2ESR1, CHGB, CHGA
49neutropenia10.2BLZF1, ERBB2, KLK3
50pheochromocytoma10.2ENO2, CHGA, CHGB

Graphical network of the top 20 diseases related to Female Breast Carcinoma:



Diseases related to female breast carcinoma

Symptoms for Female Breast Carcinoma

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Drugs & Therapeutics for Female Breast Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Female Breast Carcinoma

Search NIH Clinical Center for Female Breast Carcinoma

Genetic Tests for Female Breast Carcinoma

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Anatomical Context for Female Breast Carcinoma

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MalaCards organs/tissues related to Female Breast Carcinoma:

32
Breast, Lymph node, Prostate

Animal Models for Female Breast Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Female Breast Carcinoma:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4CD44, CDK4, CDKN2A, ESR1, TP53
2MP:00053678.4TP53, BRCA1, ESR1, CHGA, CDK4, CD44
3MP:00053808.1TP53, BRCA1, PGR, ESR1, ERBB2, CDKN2A
4MP:00053817.9MLH1, TP53, BRCA1, ESR1, ERBB2, CDKN2A
5MP:00053697.8TP53, BRCA1, PGR, ESR1, ERBB2, CDKN2A
6MP:00053887.8TP53, BRCA1, ESR1, ERBB2, ENO2, CDKN2A
7MP:00053717.7BLZF1, TP53, BRCA1, PGR, ESR1, ERBB2
8MP:00053977.7TP53, BRCA1, PGR, ESR1, CDKN2A, CDK4
9MP:00020067.6MLH1, TP53, BRCA1, PGR, ESR1, ERBB2
10MP:00107717.6MLH1, TP53, BRCA1, PGR, ESR1, ERBB2
11MP:00053787.6TP53, BRCA1, ESR1, CHGA, ERBB2, CDKN2A
12MP:00053877.5TP53, BRCA1, PGR, ESR1, CDKN2A, CDK4
13MP:00053857.4TP53, BRCA1, PGR, ESR1, CHGA, VASH1
14MP:00053897.4MLH1, TP53, BRCA1, PGR, ESR1, CHGA
15MP:00053907.3BLZF1, TP53, BRCA1, PGR, ESR1, ERBB2
16MP:00036317.2TP53, BRCA1, ESR1, CHGB, ERBB2, ENO2
17MP:00053867.2TP53, BRCA1, PGR, ESR1, ERBB2, ENO2
18MP:00107687.2MLH1, TP53, BRCA1, PGR, ESR1, CHGA
19MP:00053797.2CD44, MLH1, TP53, BRCA1, PGR, ESR1
20MP:00053767.1MLH1, TP53, BRCA1, PGR, ESR1, CHGB
21MP:00053847.1MLH1, TP53, BRCA1, PGR, ESR1, ERBB2

Publications for Female Breast Carcinoma

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Articles related to Female Breast Carcinoma:

(show all 28)
idTitleAuthorsYear
1
Risk factors of female breast carcinoma: a case control study at Puducherry. (23713049)
2013
2
Intratumoral estrogen concentration and expression of estrogen-induced genes in male breast carcinoma: comparison with female breast carcinoma. (23096432)
2013
3
Prevalence of known prognostic factors in female breast carcinoma including oestrogen receptor, progesterone receptor and Her-2/neu status--a study in a tertiary care centre. (23936949)
2012
4
Prostate-specific antigen and hormone receptor expression in male and female breast carcinoma. (20863373)
2010
5
Age related association of Her-2/neu with prognostic markers in female breast carcinoma. (20810050)
2010
6
Inter- and intra-ethnic differences for female breast carcinoma incidence in the continental United States and in the state of Hawaii. (16322891)
2006
7
Correlation of her-2/neu gene amplification with other prognostic and predictive factors in female breast carcinoma. (15982396)
2005
8
The role of CD44v3 expression in female breast carcinomas. (14998292)
2003
9
Status of HER-2 in male and female breast carcinoma. (11720677)
2001
10
Female breast carcinomas: nuclear and cytoplasmic proteins versus steroid receptors. (10756981)
2000
11
Germline BRCA1 and HMLH1 mutations in a family with male and female breast carcinoma. (10709098)
2000
12
Low-stage carcinoma of the male breast. A histologic, immunohistochemical, and flow cytometric comparison with localized female breast carcinoma. (9894455)
1999
13
Time trend of female breast carcinoma in situ by race and histology in Connecticut, USA. (9071907)
1997
14
Allium vegetable consumption, garlic supplement intake, and female breast carcinoma incidence. (7749142)
1995
15
Analysis of MTS1/CDK4 in female breast carcinomas. (7889533)
1995
16
Argyrophilia and granin (chromogranin/secretogranin) expression in female breast carcinomas. Their relationship to survival and other disease parameters. (1376022)
1992
17
Expression of tumour markers CA50, CEA and TPA in female breast carcinoma as related to histopathological findings and survival. (1567186)
1992
18
Hormone receptor status and mitotic activity as risk factors for recurrence and death in female breast carcinoma. (1768039)
1991
19
Regional lymph node reactions related to hormone receptor status in female breast carcinoma. (4004508)
1985
20
Hormone receptor levels related to histological parameters of tumor-host relationships in female breast carcinoma. (6287111)
1982
21
Histochemically demonstrable enzyme activities and their independence of the hormone receptor content in female breast carcinoma. (6298092)
1982
22
Paracortical activity in the lymph nodes draining female breast carcinoma. (311901)
1979
23
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. V. PHENOL,4,4'-(DL-1,2-DIETHYL-ETHYLENE)DI- AND ANDROST-4-EN-3-ONE, 9-CHLORO-11-BETA, 17-BETA-DIHYDROXY-17-METHYL-. (14278041)
1965
24
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. IV. 17-BETA-AMINO-5-ALPHA-ANDROSTAN-11-BETA-OL. (14176991)
1964
25
HORMONAL THERAPY OF METASTATIC FEMALE BREAST CARCINOMA. III. ANDROST-4-EN-3-ONE-2ALPHA,17BETA-DIHYDROXY DIPROPIONATE AND ANDROST-4-EN-3-ONE-16ALPHA, 17BETA-DIHYDROXY DIPROPIONATE. (14050008)
1963
26
Hormonal therapy of metastatic female breast carcinoma. II. 2alpha-Methyl dihydrotestosterone propionate. (13706491)
1961
27
The present controversy in the treatment of female breast carcinoma. (13665202)
1959
28
Hormonal therapy of metastatic female breast carcinoma. I. 9 alpha-Bromo-11-ketoprogesterone. (13663018)
1959

Variations for Female Breast Carcinoma

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Expression for genes affiliated with Female Breast Carcinoma

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Expression patterns in normal tissues for genes affiliated with Female Breast Carcinoma

Search GEO for disease gene expression data for Female Breast Carcinoma.

Pathways for genes affiliated with Female Breast Carcinoma

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Pathways related to Female Breast Carcinoma according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7MLH1, TP53
29.7CDK4, PGR, MLH1
39.6BRCA1, TP53
49.6BRCA1, TP53
59.6BRCA1, TP53
69.6BRCA1, TP53
7
Show member pathways
9.6MLH1, BRCA1, CDK4
8
Show member pathways
9.6CDK4, BRCA1, MLH1
9
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.5CDK4, ESR1, PGR
109.5CDKN2A, TP53
11
Show member pathways
9.5CDKN2A, TP53
12
Show member pathways
Signal transduction PTEN pathway60
9.4ERBB2, TP53, MLH1
13
Show member pathways
FOXA transcription factor networks37
9.4BRCA1, ESR1, KLK3
14
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.4CDK4, CDKN2A, BRCA1
159.4BRCA1, TP53, MLH1
169.4TP53, ERBB2, CDK4
179.3TP53, BRCA1, CDK4
18
Show member pathways
9.3CDK4, BRCA1, TP53
199.3TP53, BRCA1, CDK4
20
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.3ERBB2, ESR1, TP53
21
Show member pathways
9.2TP53, CDKN2A, CDK4
22
Show member pathways
Cell cycle37
9.2TP53, CDKN2A, CDK4
239.2CDK4, CDKN2A, TP53
24
Show member pathways
9.2TP53, CDKN2A, CDK4
259.2TP53, CDKN2A, CDK4
269.2CDK4, CDKN2A, TP53
279.2CDK4, CDKN2A, TP53
289.1CD44, CDKN2A, TP53
29
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.0TP53, BRCA1, KLK3, CDK4
30
Show member pathways
9.0TP53, BRCA1, ESR1, CDK4
319.0TP53, BRCA1, ESR1, CDK4
32
Show member pathways
8.9TP53, ERBB2, CDKN2A, CDK4
338.9TP53, ESR1, ERBB2, CD44
34
Show member pathways
DNA damage response37
8.9CDK4, CDKN2A, BRCA1, TP53
358.9CD44, CDK4, ESR1, TP53
36
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
8.8TP53, ERBB2, CDKN2A, CD44
378.7TP53, BRCA1, ESR1, ERBB2, CDK4
38
Show member pathways
8.6MLH1, TP53, BRCA1, CDKN2A, CDK4
398.5CD44, CDKN2A, ERBB2, BRCA1, TP53
408.3MLH1, TP53, ERBB2, KLK3, CDKN2A, CDK4
41
Show member pathways
Signaling Pathways in Glioblastoma37
8.3CDK4, CDKN2A, KLK3, ERBB2, BRCA1, TP53
42
Show member pathways
8.2CDK4, CDKN2A, ERBB2, ESR1, BRCA1, TP53
43
Show member pathways
8.2TP53, BRCA1, ESR1, ERBB2, CDKN2A, CDK4
44
Show member pathways
8.1BLZF1, TP53, BRCA1, CDKN2A, CDK4

Compounds for genes affiliated with Female Breast Carcinoma

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Compounds related to Female Breast Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 215)
idCompoundScoreTop Affiliating Genes
1megestrol acetate449.5PGR, ERBB2, KLK3, ESR1
2estracyt449.5CHGA, ENO2, KLK3
35-methylcytosine44 2410.2MLH1, CDKN2A, BRCA1, TP53
4p002449.2CHGA, BRCA1, MLH1, ERBB2, CD44
5flutamide44 61 1111.1PGR, ENO2, KLK3, ESR1, CHGA
6taxane449.1ERBB2, KLK3, ESR1, PGR, TP53
7geldanamycin44 50 61 1112.0PGR, ESR1, TP53, CDK4, ERBB2
8biotin44 24 1111.0CD44, CDKN2A, KLK3, MLH1, ERBB2
9indole-3-carbinol449.0KLK3, ESR1, BRCA1, CDK4, TP53
10folate448.9BRCA1, PGR, CDKN2A, ERBB2, MLH1
11bromodeoxyuridine448.9CHGA, MLH1, CDK4, ENO2, CD44
12gnrh448.9PGR, CHGA, ERBB2, CD44, ESR1, KLK3
13resveratrol44 61 24 1111.8BRCA1, PGR, ESR1, ERBB2, CDK4, TP53
14thymidylate448.8CDKN2A, CDK4, ERBB2, BRCA1, TP53, MLH1
15vitamin d448.7KLK3, CD44, CHGA, ESR1, CDK4, ERBB2
16camptothecin44 61 1110.7CDKN2A, BRCA1, CDK4, KLK3, MLH1, TP53
17diethylstilbestrol44 28 1110.7PGR, KLK3, ENO2, ESR1
185-aza-2deoxycytidine448.6MLH1, BRCA1, CDKN2A, ESR1, TP53, PGR
19vincristine44 50 1110.6CDKN2A, TP53, BRCA1, KLK3, CD44
20adriamycin448.6CD44, ERBB2, BRCA1, TP53, CDKN2A, PGR
21guanine44 24 1110.6TP53, CHGA, ERBB2, KLK3, ENO2, BRCA1
22methotrexate50 44 1110.6PGR, ENO2, CDKN2A, ERBB2, ESR1, BRCA1
23cyclophosphamide44 50 1110.5PGR, ERBB2, ESR1, CHGA, BRCA1, TP53
24tamoxifen44 50 28 1111.4PGR, BRCA1, TP53, ESR1, CHGA, CD44
25formaldehyde44 249.2ENO2, KLK3, ERBB2, CD44, CHGA, BLZF1
265fluorouracil448.1MLH1, CDK4, PGR, CDKN2A, ERBB2, TP53
27agarose448.1CDKN2A, MLH1, BLZF1, CD44, BRCA1
28mg 13244 619.0BRCA1, ESR1, CDKN2A, BLZF1, TP53
29etoposide44 50 61 1111.0CD44, MLH1, TP53, BRCA1, KLK3, ERBB2
30genistein44 28 61 2 24 1113.0PGR, CDK4, BLZF1, CDKN2A, BRCA1, ESR1
31butyrate447.9BLZF1, TP53, KLK3, CDKN2A, CDK4, CD44
32dexamethasone44 50 28 1110.8CD44, CDK4, CDKN2A, ENO2, KLK3, CHGA
33docetaxel44 50 61 1110.8ERBB2, CDKN2A, PGR, BRCA1, TP53, ENO2
34carboplatin44 50 119.7CDK4, CD44, ENO2, KLK3, ERBB2, MLH1
35arginine447.5CDKN2A, CHGA, ERBB2, MLH1, CD44, TP53
36doxorubicin44 50 119.4CDK4, CDKN2A, KLK3, ERBB2, ESR1, PGR
37oxygen44 248.4CDKN2A, CD44, CDK4, ENO2, CHGA, MLH1
38alanine447.2ENO2, CDKN2A, PGR, CDK4, CD44, MLH1
39paclitaxel44 50 119.1MLH1, TP53, BRCA1, PGR, ESR1, CHGA
40tyrosine447.1ENO2, ERBB2, BRCA1, BLZF1, CHGA, MLH1
41serine446.9CD44, CHGB, CHGA, BRCA1, ERBB2, KLK3
42steroid446.8CD44, CDK4, CDKN2A, KLK3, ERBB2, CHGA
43paraffin446.6KLK3, CHGA, ESR1, PGR, BRCA1, TP53
44cycloheximide446.6KLK3, CDKN2A, CDK4, ERBB2, CHGA, ESR1
45testosterone44 61 24 119.5CDK4, BRCA1, PGR, CDKN2A, ESR1, CHGA
46cisplatin44 50 61 119.4CHGA, ERBB2, ENO2, CDKN2A, CDK4, CD44
47retinoic acid44 247.4CHGA, MLH1, CDKN2A, CDK4, CD44, ENO2
48progesterone44 28 61 24 1110.1CD44, CDK4, CDKN2A, ENO2, ERBB2, CHGA
49vegf446.0CD44, CDK4, CDKN2A, ENO2, KLK3, ERBB2
50estrogen445.6CD44, CDK4, CDKN2A, ENO2, KLK3, ERBB2

GO Terms for genes affiliated with Female Breast Carcinoma

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Cellular components related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.5CDKN2A, TP53
2nucleoplasmGO:0056547.9CDK4, CDKN2A, ESR1, PGR, BRCA1, TP53

Biological processes related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of immature T cell proliferation in thymusGO:0330889.8CDKN2A, ERBB2
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.5TP53, BRCA1
3replicative senescenceGO:0903999.5CDKN2A, TP53
4positive regulation of cell cycle arrestGO:0711589.3CDKN2A, BRCA1, TP53
5regulation of apoptotic processGO:0429819.3ESR1, BRCA1, TP53
6cell cycle arrestGO:0070508.6CDKN2A, VASH1, TP53

Molecular functions related to Female Breast Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.8ESR1, PGR
2MDM2/MDM4 family protein bindingGO:0973719.4TP53, CDKN2A
3ubiquitin protein ligase bindingGO:0316258.5BRCA1, TP53, BLZF1
4enzyme bindingGO:0198998.2ESR1, PGR, BRCA1, TP53, BLZF1
5protein bindingGO:0055156.7PGR, BRCA1, TP53, MLH1, ESR1, CHGB

Products for genes affiliated with Female Breast Carcinoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Female Breast Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet