MCID: FML039
MIFTS: 40

Female Reproductive System Disease

Categories: Reproductive diseases

Aliases & Classifications for Female Reproductive System Disease

MalaCards integrated aliases for Female Reproductive System Disease:

Name: Female Reproductive System Disease 12 14
Female Reproductive System Disorder 69
Genital Diseases, Female 41

Classifications:



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Disease Ontology 12 DOID:229
ICD9CM 34 629.9
MeSH 41 D005831

Summaries for Female Reproductive System Disease

Disease Ontology : 12 A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes.

MalaCards based summary : Female Reproductive System Disease, also known as female reproductive system disorder, is related to endometriosis and uterine anomalies, and has symptoms including discomfort of vulva, mastoscirrhus and burning feeling vagina. An important gene associated with Female Reproductive System Disease is AMH (Anti-Mullerian Hormone), and among its related pathways/superpathways are NF-KappaB Family Pathway and Glucocorticoid receptor regulatory network. The drugs Hormones and insulin have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and ovary, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 72 The female reproductive system (or female genital system) is made up of the internal and external sex... more...

Related Diseases for Female Reproductive System Disease

Diseases related to Female Reproductive System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 endometriosis 31.9 CXCL8 CYP19A1 GNRH1 IL6 PGR
2 uterine anomalies 31.6 CXCL8 CYP19A1 IL6 OXT SERPINH1 TLR9
3 ectopic pregnancy 10.9
4 pituitary infarct 10.7 GNRH1 PRL
5 precocious puberty, male-limited 10.6 CYP19A1 FSHR
6 hypoactive sexual desire disorder 10.6 CYP19A1 SHBG
7 mccune-albright syndrome 10.6 AMH CYP19A1 PRL
8 endometriosis of uterus 10.6 GNRH1 PRL
9 intracystic papillary adenoma 10.6 PGR PRL
10 endometriosis of ovary 10.6 AMH CYP19A1 PGR
11 mammographic density 10.6 CYP19A1 PGR PRL
12 oocyte maturation defect 1 10.6 BMP15 CYP19A1
13 hypogonadotropism 10.6 GNRH1 PRL
14 recurrent corneal erosion 10.6 CXCL8 IL6
15 leiomyoma, uterine 10.6 CYP19A1 GNRH1 PGR
16 androgenic alopecia 10.6 CYP19A1 PRL SHBG
17 musculoskeletal system benign neoplasm 10.6 GNRH1 PGR TLR9
18 bagassosis 10.6 CXCL8 IL6
19 sex cord-gonadal stromal tumor 10.6 CYP19A1 FOXL2 PGR
20 juvenile nasopharyngeal angiofibroma 10.6 CYP19A1 PGR TLR9
21 nasal cavity disease 10.6 CXCL8 TLR9 TRPV1
22 nose disease 10.6 CXCL8 TLR9 TRPV1
23 funisitis 10.6 CXCL8 IL6 SERPINH1
24 vaginal disease 10.5 CXCL8 IL6 SERPINH1
25 upper respiratory tract disease 10.5 CXCL8 TLR9 TRPV1
26 vaginitis 10.5 CXCL8 IL6 SERPINH1
27 preterm premature rupture of the membranes 10.5 CXCL8 IL6 SERPINH1
28 ovarian hyperstimulation syndrome 10.5 AMH CYP19A1 FSHR GNRH1
29 pulpitis 10.5 CXCL8 IL6 TRPV1
30 interstitial cystitis 10.5 CXCL8 IL6 TRPV1
31 cervical incompetence 10.5 IL6 SERPINH1
32 hypersensitivity reaction disease 10.5 IL6 TLR9 TRPV1
33 varicocele 10.5 AMH GNRH1 PRL SHBG
34 mouth disease 10.5 IL6 TLR9 TRPV1
35 eye lymphoma 10.5 IL6 TLR9
36 esophagitis 10.5 CXCL8 IL6 TRPV1
37 cystitis 10.5 CXCL8 IL6 TRPV1
38 cryptorchidism, unilateral or bilateral 10.5 AMH CYP19A1 GNRH1 SHBG
39 breast disease 10.5 PGR PRL SHBG
40 sexual disorder 10.5 OXT PRL SHBG
41 specific developmental disorder 10.5 FMR1 OXT TRPV1
42 urinary system disease 10.5 IL6 TLR9 TRPV1
43 hypothalamic disease 10.5 GNRH1 PRL
44 hyperandrogenism 10.5 CYP19A1 GNRH1 PRL SHBG
45 gonadal disease 10.5 AMH FSHR GNRH1 SHBG
46 overnutrition 10.5 IL6 SHBG TRPV1
47 leiomyoma 10.5 CYP19A1 GNRH1 PGR
48 progesterone-receptor positive breast cancer 10.5 CYP19A1 PGR
49 tonsillitis 10.5 CXCL8 IL6 TLR9
50 gonadal dysgenesis 10.5 AMH BMP15 FOXL2 FSHR

Graphical network of the top 20 diseases related to Female Reproductive System Disease:



Diseases related to Female Reproductive System Disease

Symptoms & Phenotypes for Female Reproductive System Disease

UMLS symptoms related to Female Reproductive System Disease:


discomfort of vulva, mastoscirrhus, burning feeling vagina, vaginal pain, vaginal discomfort, menopausal symptoms, vaginal odor, genitalia external painful, perineal pain female, menometrorrhagia, nipple discharge, breast engorgement, vaginal pruritus, pruritus vulvae, genital itching, mastodynia, leukorrhea

MGI Mouse Phenotypes related to Female Reproductive System Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.2 GNRH1 AREG IL6 BMP15 CYP19A1 NOBOX
2 homeostasis/metabolism MP:0005376 10.07 AMH GNRH1 AREG IL6 CYP19A1 OXT
3 digestive/alimentary MP:0005381 9.91 GNRH1 AREG IL6 CYP19A1 OXT SERPINH1
4 integument MP:0010771 9.85 GNRH1 AREG IL6 CYP19A1 OXT FMR1
5 neoplasm MP:0002006 9.5 AMH GNRH1 IL6 PGR FSHR TRPV1
6 reproductive system MP:0005389 9.5 AREG IL6 BMP15 CYP19A1 NOBOX OXT

Drugs & Therapeutics for Female Reproductive System Disease

Drugs for Female Reproductive System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones
2 insulin
3 Insulin, Globin Zinc

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Modifications of Nutritional Intake Upon Reproductive Hormones in Normal Women Completed NCT02233283

Search NIH Clinical Center for Female Reproductive System Disease

Cochrane evidence based reviews: genital diseases, female

Genetic Tests for Female Reproductive System Disease

Anatomical Context for Female Reproductive System Disease

MalaCards organs/tissues related to Female Reproductive System Disease:

38
Uterus, Cervix, Ovary

Publications for Female Reproductive System Disease

Variations for Female Reproductive System Disease

Expression for Female Reproductive System Disease

Search GEO for disease gene expression data for Female Reproductive System Disease.

Pathways for Female Reproductive System Disease

GO Terms for Female Reproductive System Disease

Cellular components related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 AMH BMP15 CXCL8 GDF9 GNRH1 IL6
2 extracellular space GO:0005615 9.36 AMH AREG BMP15 CXCL8 GDF9 GNRH1

Biological processes related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.72 GNRH1 OXT PRL
2 BMP signaling pathway GO:0030509 9.71 AMH BMP15 GDF9
3 response to organic cyclic compound GO:0014070 9.71 AMH AREG GNRH1 OXT
4 response to glucocorticoid GO:0051384 9.65 AREG IL6 OXT
5 regulation of MAPK cascade GO:0043408 9.61 BMP15 FSHR GDF9
6 response to molecule of bacterial origin GO:0002237 9.52 CXCL8 TLR9
7 gonad development GO:0008406 9.51 AMH FSHR
8 female gonad development GO:0008585 9.5 CYP19A1 FOXL2 FSHR
9 negative regulation of bone resorption GO:0045779 9.49 FSHR IL6
10 response to prostaglandin E GO:0034695 9.46 GNRH1 OXT
11 female gamete generation GO:0007292 9.43 BMP15 FSHR GDF9
12 oocyte growth GO:0001555 9.37 FOXL2 GDF9
13 uterus development GO:0060065 9.33 CYP19A1 FOXL2 FSHR
14 regulation of receptor activity GO:0010469 9.32 AMH AREG BMP15 CXCL8 GDF9 GNRH1
15 response to peptide hormone GO:0043434 9.26 AREG GNRH1 OXT TRPV1

Molecular functions related to Female Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.46 AMH GNRH1 OXT PRL
2 transforming growth factor beta receptor binding GO:0005160 9.43 AMH BMP15 GDF9
3 cytokine activity GO:0005125 9.35 AREG BMP15 CXCL8 GDF9 IL6
4 siRNA binding GO:0035197 9.32 FMR1 TLR9
5 growth factor activity GO:0008083 9.02 AMH AREG BMP15 GDF9 IL6

Sources for Female Reproductive System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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