MCID: FML031
MIFTS: 40

Female Stress Incontinence malady

Categories: Nephrological diseases

Aliases & Classifications for Female Stress Incontinence

Aliases & Descriptions for Female Stress Incontinence:

Name: Female Stress Incontinence 38 12 14 69
Female Urinary Stress Incontinence 12
Stress Incontinence - Female 12

Classifications:



External Ids:

Disease Ontology 12 DOID:724
ICD9CM 35 625.6
NCIt 47 C35042
UMLS 69 C0038437

Summaries for Female Stress Incontinence

MalaCards based summary : Female Stress Incontinence, also known as female urinary stress incontinence, is related to vaginitis and tinea pedis, and has symptoms including unspecified symptom associated with female genital organs, mittelschmerz and pain and other symptoms associated with female genital organs. An important gene associated with Female Stress Incontinence is MEOX2 (Mesenchyme Homeobox 2), and among its related pathways/superpathways are Paroxetine Pathway, Pharmacokinetics and Phenytoin Pathway, Pharmacokinetics. The drugs Dopamine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone and testes, and related phenotype is taste/olfaction.

Related Diseases for Female Stress Incontinence

Diseases related to Female Stress Incontinence via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 vaginitis 10.2
2 tinea pedis 10.1 CYP1A2 CYP2D6
3 urethritis 10.0
4 trichomegaly 10.0 CYP1A2 CYP2D6
5 teratoma with malignant transformation 10.0 CYP1A2 CYP2D6
6 gas gangrene 8.3 ANG CREM CYP1A2 CYP2D6 LAX1 MEOX2

Comorbidity relations with Female Stress Incontinence via Phenotypic Disease Network (PDN):


Endometriosis of Uterus Hypothyroidism
Leukoplakia of Vagina Postmenopausal Atrophic Vaginitis
Submucous Uterine Fibroid Subserous Uterine Fibroid
Trigonitis Urethral Intrinsic Sphincter Deficiency
Uterine Fibroid

Graphical network of the top 20 diseases related to Female Stress Incontinence:



Diseases related to Female Stress Incontinence

Symptoms & Phenotypes for Female Stress Incontinence

UMLS symptoms related to Female Stress Incontinence:


unspecified symptom associated with female genital organs, mittelschmerz, pain and other symptoms associated with female genital organs, other specified symptoms associated with female genital organs, female genital pain and other symptoms

MGI Mouse Phenotypes related to Female Stress Incontinence:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.8 MEOX2 SLC6A1 TERT

Drugs & Therapeutics for Female Stress Incontinence

Drugs for Female Stress Incontinence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
2
Norepinephrine Approved Phase 4,Phase 3,Phase 2 51-41-2 439260
3
Benzocaine Approved Phase 4,Phase 2,Phase 3 1994-09-7, 94-09-7 2337
4
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
5
Oxybutynin Approved, Investigational Phase 4 5633-20-5 4634
6
Acetylcholine Approved Phase 4 51-84-3 187
7
Menthol Approved Phase 4,Phase 1,Phase 2 2216-51-5 16666
8 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3
9 Calcium, Dietary Phase 4
10 Analgesics Phase 4,Phase 3,Phase 2
11 Antidepressive Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Dopamine Agents Phase 4,Phase 3,Phase 2
13 Duloxetine Hydrochloride Phase 4,Phase 3,Phase 2
14 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
16 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
17 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1
18
Serotonin Phase 4,Phase 3,Phase 2 50-67-9 5202
19 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4,Phase 3,Phase 2
20 Cholinergic Agents Phase 4
21 Cholinergic Antagonists Phase 4
22 Muscarinic Antagonists Phase 4
23 Solifenacin succinate Phase 4 242478-38-2
24
Imidacloprid Phase 4 105827-78-9 86418
25 Anti-Infective Agents Phase 4
26 Renal Agents Phase 4
27 Tolterodine tartrate Phase 4 124937-52-6
28 Autonomic Agents Phase 4
29 Mandelic Acids Phase 4
30 Parasympatholytics Phase 4
31 Cariostatic Agents Phase 4
32 Fluorides Phase 4
33 Protective Agents Phase 4
34 abobotulinumtoxinA Phase 4
35 Botulinum Toxins Phase 4
36 Botulinum Toxins, Type A Phase 4
37 incobotulinumtoxinA Phase 4
38 Neuromuscular Agents Phase 4
39 onabotulinumtoxinA Phase 4
40
Glycerol Approved, Experimental Phase 2, Phase 3 56-81-5 753
41 Anesthetics Phase 3,Phase 2
42 Pharmaceutical Solutions Phase 3
43
Reboxetine Approved, Investigational Phase 2 98769-81-4, 71620-89-8 123628 65856
44
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
45
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
46
Lorazepam Approved Phase 2 846-49-1 3958
47
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
48
Morphine Approved, Investigational Phase 2 57-27-2 5288826
49 Anesthetics, Local Phase 2
50 Anti-Arrhythmia Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 255)
id Name Status NCT ID Phase
1 Treatment of Female Stress Urinary Incontinence: Study Comparing Two Suburethral Slings, Retropubic Approach (TVT) and Trans-Obturator (TVT-O) Approach Unknown status NCT00135616 Phase 4
2 TVTO™ X TVTS ™ for Treatment of Stress Urinary Incontinence Unknown status NCT01095159 Phase 4
3 A Comparative Study Minisling Versus Transobturator (TOT)Sling Unknown status NCT01094353 Phase 4
4 MiniArc Study: Long-Term Effectiveness Trial for AMS Sling Systems Unknown status NCT00541151 Phase 4
5 Assessment of the Effectiveness of a Program of Preparation to Pregnancy and Delivery Unknown status NCT01155804 Phase 4
6 Autologous Versus Synthetic Versus Biological Sling for Trans-obturator Correction of Urinary Stress Incontinence Unknown status NCT00744198 Phase 4
7 Interest of Intravaginal Electro-stimulation at Home by GYNEFFIK® Compared to Usual Care in Incontinent Patients With Prior Perineal Reeducation Unknown status NCT02029027 Phase 4
8 Surgical Treatment To Greater Anterior Vaginal Prolapse Unknown status NCT00676325 Phase 4
9 A Randomized Controlled Study Comparing Three Single-incision Devices for Female Urinary Stress Incontinence Completed NCT00751088 Phase 4
10 Clinical and Urodynamic Effects of Minimally Laser (IncontiLaseTM) Procedure for Female Stress Urinary Incontinence Completed NCT02130375 Phase 4
11 Post Approval Study of Coaptite® in the Treatment of Female Urinary Incontinence Completed NCT00996489 Phase 4
12 Safety and Effectiveness Study of Duloxetine HCl in Women of Different Backgrounds With Stress Urinary Incontinence Who May Also Have Other Various Medical Conditions. Completed NCT00190905 Phase 4
13 A Study to Estimate the Efficacy and Safety of Solifenacin in Female With Stress Urinary Incontinence and Urgency Urinary Incontinence Completed NCT01505439 Phase 4
14 To Determine How Effective Duloxetine is in Treating Women 65 Years and Older With Symptoms of Stress Urinary Incontinence, or With a Combination of Stress Urinary Incontinence and Urge Urinary Incontinence Symptoms Completed NCT00244296 Phase 4
15 Evaluating the Change of Overactive Bladder Symptoms in Women Post Pubovaginal Sling Procedure for Stress Incontinence Completed NCT01194999 Phase 4
16 Retropubic Single Incision Minisling Versus Tension Free Vaginal Tape for Management of Stress Urinary Incontinence Completed NCT02263534 Phase 4
17 A 3 Year Follow-up Prospective Open Randomized Trial of TVT Versus Colposuspension for Primary Stress Incontinence Completed NCT00782990 Phase 4
18 Post Market Clinical Study to Evaluate a Mid-Urethral Vaginal Tape Procedure With a Pre-Pubic Delivery Approach, for the Treatment of Stress Urinary Incontinence Completed NCT00688298 Phase 4
19 Does Treatment With Macrobid Reduce Urinary Tract Infections in Patients Receiving a Sub-Urethral Sling for Incontinence Completed NCT00734968 Phase 4
20 Value of Urodynamic Evaluation Completed NCT00803959 Phase 4
21 Athena Pelvic Muscle Trainer - DUETS Trial Completed NCT01073878 Phase 4
22 TOMUS-Trial Of Mid-Urethral Slings Completed NCT00325039 Phase 4
23 Comparison of Burch Urethropexy and Mid-urethral Sling Performed Concomitantly With a Sacral Colpopexy Completed NCT00934999 Phase 4
24 Over Active Bladder Patients Having Sling Surgery Completed NCT00852696 Phase 4
25 Clinical Outcomes and Urodynamic Effects After Vaginal Tailored Mesh Surgery for Pelvic Organ Prolapse Completed NCT02178735 Phase 4
26 Efficacy of a Combined Surgical and Pharmacological Therapy to Treat Mixed Urinary Incontinence. Completed NCT01899794 Phase 4
27 Comparative Study of PDVF and Polypropylene Transobturator Suburethral Tapes Recruiting NCT02886520 Phase 4
28 The SLIM Study: Sling and Botox® Injection for Mixed Urinary Incontinence Recruiting NCT02678377 Phase 4
29 TVT-ABBREVO Versus SERASIS for the Treatment of Female Urinary Stress Incontinence: 1 Year Outcomes of a Comparative Study With 2 Trans-obturator Sub Mid Urethral Slings Not yet recruiting NCT02867748 Phase 4
30 Weighted Vaginal Cones Versus Biofeedback in the Treatment of Urodynamic Stress Incontinence: a Randomized Trial. Terminated NCT00247286 Phase 4
31 Incontinence Ring on Stress Urinary Incontinence Terminated NCT00427778 Phase 4
32 Anterior Defect Correction With Mesh Plus Treatment of Stress Incontinence With Transobturator or Transvaginal Approach Terminated NCT00743535 Phase 4
33 Mixed Incontinence: Medical Or Surgical Approach? Terminated NCT00803270 Phase 4
34 A Comparison of Tolterodine and Placebo Treatments on Nocturnal Frequency and Sleep Quality in Women After Menopause. Terminated NCT00323635 Phase 4
35 Laparoscopic Burch Colposuspension Versus Transobturatory Tape for the Treatment of Female Urinary Stress Incontinence Withdrawn NCT00573703 Phase 4
36 Treatment of Urinary Stress Incontinence During or Following Correction of Pelvic Organ Prolapse Withdrawn NCT00697489 Phase 4
37 Randomized, Multicenter Trial Comparing TVT With TVT-O for Treatment of Female Urinary Incontinence Unknown status NCT00379314 Phase 3
38 Bulkamid Treatment of Stress Incontinence in Women With Urinary Stress Incontinence and Not Suitable to TVT-procedure Unknown status NCT00984958 Phase 3
39 Safety and Efficacy Study of Regen Sling to Treatment SUI Unknown status NCT02106299 Phase 3
40 Mechanical Nerve Stimulation in the Treatment of Post Prostatectomy Incontinence Unknown status NCT01540656 Phase 3
41 Autologous Muscle-derived Cells Female Stress Urinary Incontinence Clinical Study Completed NCT01382602 Phase 3
42 Adjustable Continence Therapy (ACT) Device for the Treatment of Female Stress Urinary Incontinence Completed NCT00113555 Phase 2, Phase 3
43 The AttenueX IntraVesical System for the Treatment of Female Stress Urinary Incontinence Completed NCT00492596 Phase 3
44 A Study to Evaluate the Effectiveness of the Induced Reflex Cough Test Plus Urodynamics to Identify Stress Urinary Incontinence in Female Subjects With a History of Stress Urinary Incontinence Completed NCT00801203 Phase 2, Phase 3
45 Biomechanical and Electrophysiological Effects of Duloxetine in the Treatment of Women With Urinary Stress Incontinence Completed NCT00190853 Phase 3
46 Effectiveness of Circular Muscle Exercise (Paula Method) Versus Kegel Exercise for Urinary Stress Incontinence Completed NCT00197314 Phase 3
47 Randomised Controlled Trial Comparing Tension-Free Vaginal Tape (TVT), Pelvicol & Autologous Slings for Stress Urinary Incontinence(SUI) Completed NCT01057550 Phase 3
48 Comparison of Surgical Procedures to Reduce Urinary Stress Incontinence Completed NCT00064662 Phase 2, Phase 3
49 Behavioral Intervention Program and Vaginal Cones on SUI Completed NCT01628991 Phase 2, Phase 3
50 ATLAS: Ambulatory Treatments for Leakage Associated With Stress Completed NCT00270998 Phase 3

Search NIH Clinical Center for Female Stress Incontinence

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Female Stress Incontinence cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Female Stress Incontinence:
AMDC, autologous muscle-derived cells for urinary incontinence
ICES13, autologous myoblasts for stress urinary incontinence
Embryonic/Adult Cultured Cells Related to Female Stress Incontinence:
Autologous muscle-derived cells PMIDs: 23260547
Muscle-derived myoblasts

Genetic Tests for Female Stress Incontinence

Anatomical Context for Female Stress Incontinence

MalaCards organs/tissues related to Female Stress Incontinence:

39
Bone, Testes

Publications for Female Stress Incontinence

Articles related to Female Stress Incontinence:

(show top 50) (show all 82)
id Title Authors Year
1
Is the adjustable TVA mesh effective for the long-term treatment of female stress incontinence? ( 27496772 )
2016
2
Efficacy of Electrical Pudendal Nerve Stimulation in Treating Female Stress Incontinence. ( 26921645 )
2016
3
Adjustable vs. ordinary transobturator tape for female stress incontinence. Is there a difference? ( 26413335 )
2015
4
Re: efficacy and safety of polyacrylamide hydrogel for the treatment of female stress incontinence: a randomized, prospective, multicenter north american study: e. R. Sokol, m. M. Karram and R. Dmochowski j urol 2014; 192: 843-849. ( 25481730 )
2015
5
The first Iraqi experience with the rectus fascia sling and transobturator tape for female stress incontinence: A randomised trial. ( 26019950 )
2014
6
Efficacy and safety of polyacrylamide hydrogel for the treatment of female stress incontinence: a randomized, prospective, multicenter North American study. ( 24704117 )
2014
7
Long-term follow-up after urethral injection with polyacrylamide hydrogel for female stress incontinence. ( 24372312 )
2013
8
Is antibiotic prophylaxis necessary before midurethral sling procedures for female stress incontinence? A decision analysis. ( 23903818 )
2013
9
The autologous fascia pubovaginal sling for complicated female stress incontinence. ( 22396366 )
2012
10
Simultaneous perineal ultrasound and vaginal pressure measurement prove the action of electrical pudendal nerve stimulation in treating female stress incontinence. ( 22417077 )
2012
11
Transobturator tape for female stress incontinence: follow-up after 24 months. ( 20165575 )
2010
12
Are urodynamics needed before surgery for straightforward female stress incontinence? ( 20961583 )
2010
13
Are urodynamics needed before surgery for straightforward female stress incontinence? ( 20965521 )
2010
14
Transobturator tape in the management of female stress incontinence: clinical outcomes at medium term follow-up. ( 18480630 )
2008
15
Urodynamics in the management of female stress incontinence--which test and when? ( 18520755 )
2008
16
Trans-obturator suburethral tape for female stress incontinence: a cohort of 254 women with 1-year to 2-year follow-up. ( 18231894 )
2008
17
Autologous myoblasts and fibroblasts for female stress incontinence: a 1-year follow-up in 123 patients. ( 17760890 )
2007
18
Transobturator surgery for female stress incontinence: a comparative anatomical study of outside-in vs inside-out techniques. ( 17868425 )
2007
19
MRI urethrovesical junction mobility is associated with global pelvic floor laxity in female stress incontinence. ( 17851825 )
2007
20
A safety and quality of life analysis of intravaginal slingplasty in female stress incontinence: a prospective, open label, multicenter, and observational study. ( 17333435 )
2007
21
Quality of life after tension-free vaginal tape surgery for female stress incontinence. ( 16608811 )
2006
22
Transobturator tape sling for female stress incontinence with polypropylene tape and outside-in procedure: prospective study with 1 year of minimal follow-up and review of transobturator tape sling. ( 17070348 )
2006
23
Dilemmas in the management of female stress incontinence: the role of pelvic floor muscle training. ( 17136582 )
2006
24
A cost-effectiveness analysis of tension-free vaginal tape versus laparoscopic mesh colposuspension for primary female stress incontinence. ( 17260226 )
2006
25
Urethral injections for female stress incontinence. ( 16911598 )
2006
26
Trans-obturator vaginal tape (TOT) for female stress incontinence: one year follow-up in 120 patients. ( 16182440 )
2005
27
Pubovaginal bone anchor fixation with polyethylene versus fascia lata slings in the treatment of female stress incontinence: sling material and processing are predominant factors in success. ( 15877939 )
2005
28
Cost effectiveness of tension-free vaginal tape for the surgical management of female stress incontinence. ( 15609795 )
2004
29
Tension-free vaginal tape and female stress incontinence: further evidence of effectiveness. ( 15153731 )
2004
30
A costed profile audit of the surgical management of female stress incontinence. ( 15648705 )
2004
31
Anterior urethropexy according to lapides: how effective is it in the treatment of genuine female stress incontinence? ( 12701489 )
2003
32
Clinical outcome of fascial slings for female stress incontinence. ( 12142854 )
2002
33
Female stress incontinence. ( 11342928 )
2001
34
Vesicosuspension for female stress incontinence and cystocele using pubic bone anchors. ( 11820144 )
2001
35
Inguinovaginal sling procedure for female stress incontinence: introduction of a minimally invasive technique. ( 11383987 )
2001
36
The thimble: a useful adjunct to needle suspension procedures for female stress incontinence. ( 11113759 )
2000
37
Effectiveness of the conveen continence guard (a disposable vaginal device) in the treatment of complicated female stress incontinence. ( 11130086 )
2000
38
Tension-free vaginal tape (TVT) - a new surgical procedure for female stress incontinence. ( 15512507 )
2000
39
A urinary control device for management of female stress incontinence. ( 10711555 )
2000
40
beta(2)-adrenergic agonists and pelvic floor exercises for female stress incontinence. ( 11044540 )
2000
41
Outcome results of transurethral collagen injection for female stress incontinence: assessment by urinary incontinence score. ( 11061903 )
2000
42
Transurethral collagen injection for female stress incontinence. ( 9657173 )
1998
43
Minimally invasive pervaginam procedures for the treatment of female stress incontinence using a new pubic bone anchoring system. ( 9790087 )
1998
44
Bladder neck suspension using bone anchors for the treatment of female stress incontinence. ( 9152492 )
1997
45
Incisionless per vaginal bone anchor cystourethropexy for the treatment of female stress incontinence: experience with the first 50 patients. ( 9334591 )
1997
46
Long-term efficacy and safety of a disposable vaginal device (continence guard) in the treatment of female stress incontinence. ( 9449583 )
1997
47
Clinical value of vaginal cones for the management of female stress incontinence. ( 9557998 )
1997
48
New disposable vaginal device (continence guard) in the treatment of female stress incontinence. Design, efficacy and short term safety. ( 8604606 )
1996
49
Polytetrafluoroethylene sling for failure in female stress incontinence surgery. ( 8738411 )
1996
50
Female stress incontinence in the 1990s--changing concepts. ( 8863554 )
1996

Variations for Female Stress Incontinence

Expression for Female Stress Incontinence

Search GEO for disease gene expression data for Female Stress Incontinence.

Pathways for Female Stress Incontinence

GO Terms for Female Stress Incontinence

Biological processes related to Female Stress Incontinence according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 drug metabolic process GO:0017144 9.37 CYP1A2 CYP2D6
2 oxidative demethylation GO:0070989 9.32 CYP1A2 CYP2D6
3 drug catabolic process GO:0042737 9.26 CYP1A2 CYP2D6
4 heterocycle metabolic process GO:0046483 9.16 CYP1A2 CYP2D6
5 monoterpenoid metabolic process GO:0016098 8.96 CYP1A2 CYP2D6
6 alkaloid metabolic process GO:0009820 8.62 CYP1A2 CYP2D6

Molecular functions related to Female Stress Incontinence according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.5 CYP1A2 CYP2D6 PTGIS
2 oxygen binding GO:0019825 9.4 CYP1A2 CYP2D6
3 aromatase activity GO:0070330 9.37 CYP1A2 CYP2D6
4 heme binding GO:0020037 9.33 CYP1A2 CYP2D6 PTGIS
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.26 CYP1A2 CYP2D6
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.13 CYP1A2 CYP2D6 PTGIS
7 monooxygenase activity GO:0004497 8.8 CYP1A2 CYP2D6 PTGIS

Sources for Female Stress Incontinence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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