MCID: FTL006
MIFTS: 46

Fetal Alcohol Spectrum Disorder malady

Rare diseases, Neuronal diseases, Fetal diseases categories

Summaries for Fetal Alcohol Spectrum Disorder

About this section


MedlinePlus:34 Alcohol can harm your baby at any stage during a pregnancy. that includes the earliest stages before you even know you are pregnant. drinking alcohol can cause a group of conditions called fetal alcohol spectrum disorders (fasds). effects can include physical and behavioral problems such as trouble with learning and remembering understanding and following directions controlling emotions communicating and socializing daily life skills, such as feeding and bathing fetal alcohol syndrome is the most serious type of fasd. people with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. fasds last a lifetime. there is no cure for fasds. treatments can help. these include medicines to help with some symptoms and behavior therapy. no one treatment is right for every child. centers for disease control and prevention

MalaCards based summary: Fetal Alcohol Spectrum Disorder, also known as fetal alcohol spectrum disorders, is related to alcohol abuse and fetal alcohol syndrome. An important gene associated with Fetal Alcohol Spectrum Disorder is KCNK9 (potassium channel, subfamily K, member 9), and among its related pathways are FSH signaling pathway and BDNF signaling pathway. The compounds 3-nitropropionic acid and quisqualate have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotypes are normal and respiratory system.

Disease Ontology:10 A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.

Wikipedia:65 Fetal (or foetal) alcohol spectrum disorders (FASD) is a continuum of various permanent birth defects... more...

Aliases & Classifications for Fetal Alcohol Spectrum Disorder

About this section

Fetal Alcohol Spectrum Disorder, Aliases & Descriptions:

Name: Fetal Alcohol Spectrum Disorder 10 12 62
Fetal Alcohol Spectrum Disorders 43 34 62
Fasd 43 62
Alcohol-Related Neurodevelopmental Disorder - Type 43
Alcohol Related Neurodevelopmental Disorder 62
Alcohol-Related Birth Defects - Type 43
 
Fetal Alcohol Syndrome - Type 43
Alcohol-Related Birth Defects 62
Fetal Alcohol Syndrome 62
Arnd 62
Arbd 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology10 DOID:0050696

Related Diseases for Fetal Alcohol Spectrum Disorder

About this section

Graphical network of the top 20 diseases related to Fetal Alcohol Spectrum Disorder:



Diseases related to fetal alcohol spectrum disorder

Symptoms for Fetal Alcohol Spectrum Disorder

About this section

Drugs & Therapeutics for Fetal Alcohol Spectrum Disorder

About this section

Drug clinical trials:

Search ClinicalTrials for Fetal Alcohol Spectrum Disorder

Search NIH Clinical Center for Fetal Alcohol Spectrum Disorder

Genetic Tests for Fetal Alcohol Spectrum Disorder

About this section

Anatomical Context for Fetal Alcohol Spectrum Disorder

About this section

MalaCards organs/tissues related to Fetal Alcohol Spectrum Disorder:

33
Eye, Brain, Testes, Cerebellum, Placenta

Animal Models for Fetal Alcohol Spectrum Disorder or affiliated genes

About this section

MGI Mouse Phenotypes related to Fetal Alcohol Spectrum Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.6BDNF, CREB1, SRF, KCNK9
2MP:00053888.3BDNF, CREB1, SRF, KCNK9

Publications for Fetal Alcohol Spectrum Disorder

About this section

Articles related to Fetal Alcohol Spectrum Disorder:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Verbal learning and memory impairment in children with fetal alcohol spectrum disorders. (25833031)
2015
2
Self-regulation therapy increases frontal gray matter in children with fetal alcohol spectrum disorder: evaluation by voxel-based morphometry. (25788884)
2015
3
The cost of lost productivity due to fetal alcohol spectrum disorder-related premature mortality. (25594934)
2015
4
Gene-specific disruption of endocannabinoid receptor 1 (cnr1a) by ethanol probably leads to the development of fetal alcohol spectrum disorder (FASD) phenotypes in Japanese rice fish (Oryzias latipes) embryogenesis. (25251458)
2014
5
Cognitive and Adaptive Skill Profile Differences in Children With Attention-Deficit Hyperactivity Disorder With and Without Comorbid Fetal Alcohol Spectrum Disorder. (25318015)
2014
6
Fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorder (FASD)-diagnosis and moral policing; an ethical dilemma for paediatricians. (25005521)
2014
7
Looking further upstream to prevent fetal alcohol spectrum disorder in Canada. (25560892)
2014
8
An animal model of fetal alcohol spectrum disorder: Trace conditioning as a window to inform memory deficits and intervention tactics. (25477227)
2014
9
Comparisons of Intelligence and Behavior in Children With Fetal Alcohol Spectrum Disorder and ADHD. (25525157)
2014
10
Costs of health services utilization of people with fetal alcohol spectrum disorder by sex and age group in Alberta, Canada. (25658807)
2014
11
Fetal alcohol spectrum disorder--poverty trap? (23458991)
2013
12
Clinical correlates of fetal alcohol spectrum disorder among diagnosed individuals in a rural diagnostic clinic. (24163155)
2013
13
Autism spectrum disorder and fetal alcohol spectrum disorder. Part II: a qualitative comparison of parenting stress. (23672659)
2013
14
Counting fetal alcohol spectrum disorder in Australia: the evidence and the challenges. (23617437)
2013
15
Inappropriate Feeding Behaviors and Dietary Intakes in Children with Fetal Alcohol Spectrum Disorder or Probable Prenatal Alcohol Exposure. (24164456)
2013
16
Altered accuracy of saccadic eye movements in children with fetal alcohol spectrum disorder. (23578065)
2013
17
Adopted children from the former Soviet Union: are they at risk of fetal alcohol spectrum disorder? (24130279)
2013
18
Identifying the neurobehavioral phenotype of fetal alcohol spectrum disorder in young children. (24163185)
2013
19
Sensory processing and ADHD in children with fetal alcohol spectrum disorder. (22439293)
2012
20
The effectiveness of a community-based intervention program for women at-risk for giving birth to a child with Fetal Alcohol Spectrum Disorder (FASD). (20694802)
2012
21
Glycosylation defects underlying fetal alcohol spectrum disorder: a novel pathogenetic model. "When the wine goes in, strange things come out" - S.T. Coleridge, The Piccolomini. (22134542)
2012
22
Sleep and sensory characteristics in young children with fetal alcohol spectrum disorder. (21654404)
2011
23
Diffusion tensor imaging of the cerebellum and eyeblink conditioning in fetal alcohol spectrum disorder. (21790667)
2011
24
Mental health issues in fetal alcohol spectrum disorder. (21780939)
2011
25
Changes in health professionals' knowledge, attitudes and practice following provision of educational resources about prevention of prenatal alcohol exposure and fetal alcohol spectrum disorder. (21649674)
2011
26
The Canadian guidelines and the interdisciplinary clinical capacity of Canada to diagnose fetal alcohol spectrum disorder. (22124027)
2011
27
Differentiating attention deficits in children with fetal alcohol spectrum disorder or attention-deficit-hyperactivity disorder. (19549201)
2010
28
Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disorders. (20164336)
2010
29
Alcohol-induced facial dysmorphology in C57BL/6 mouse models of fetal alcohol spectrum disorder. (20570474)
2010
30
The preventive effect of oral EGCG in a fetal alcohol spectrum disorder mouse model. (20659071)
2010
31
Concordance of three methods for palpebral fissure length measurement in the assessment of fetal alcohol spectrum disorder. (19372601)
2009
32
Fetal alcohol syndrome and fetal alcohol spectrum disorder in Indigenous schoolchildren. (19296803)
2009
33
Costs of fetal alcohol spectrum disorder in Alberta, Canada. (19151424)
2009
34
Fetal alcohol spectrum disorder(FASD. (20012791)
2009
35
Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migration. (19393862)
2009
36
Modulation of glutamatergic transmission by sulfated steroids: role in fetal alcohol spectrum disorder. (17597219)
2008
37
Acid-sensitive channel inhibition prevents fetal alcohol spectrum disorders cerebellar Purkinje cell loss. (18509098)
2008
38
Development of Canadian screening tools for fetal alcohol spectrum disorder. (18840921)
2008
39
Knowledge and attitudes of criminal justice professionals in relation to Fetal Alcohol Spectrum Disorder. (18678920)
2008
40
The effect of rehearsal training on working memory span of children with fetal alcohol spectrum disorder. (17317098)
2008
41
Re-examining the core features of autism: a comparison of autism spectrum disorder and fetal alcohol spectrum disorder. (17995487)
2007
42
Fetal alcohol spectrum disorder prevention approaches among Canadian physicians by proportion of Native/Aboriginal patients: practices during the preconception and prenatal periods. (17243020)
2007
43
Research-based interventions for children and youth with a Fetal Alcohol Spectrum Disorder: revealing the gap. (17584393)
2007
44
Knowledge and attitudes about fetal alcohol syndrome, fetal alcohol spectrum disorders, and alcohol use during pregnancy by occupational therapists in the Midwest. (19759993)
2007
45
Challenges of diagnosis in fetal alcohol syndrome and fetal alcohol spectrum disorder in the adult. (17640043)
2007
46
Persistence in high school: experiences of adolescents and young adults with Fetal Alcohol Spectrum Disorder. (17178534)
2006
47
Neurobehavioral functioning in children with fetal alcohol spectrum disorder. (16952890)
2006
48
Alcohol is a potent stimulant of immature neuronal networks: implications for fetal alcohol spectrum disorder. (16000153)
2005
49
Fetal alcohol spectrum disorder. (14638655)
2003
50
Fetal alcohol spectrum disorder - New diagnostic initiatives. (20046284)
2002

Variations for Fetal Alcohol Spectrum Disorder

About this section

Expression for genes affiliated with Fetal Alcohol Spectrum Disorder

About this section

Search GEO for disease gene expression data for Fetal Alcohol Spectrum Disorder.

Pathways for genes affiliated with Fetal Alcohol Spectrum Disorder

About this section

Pathways related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CREB1, BDNF
29.5CREB1, BDNF
3
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.5BDNF, CREB1
4
Show member pathways
9.5BDNF, CREB1
5
Show member pathways
9.5BDNF, CREB1
6
Show member pathways
9.4CREB1, SRF
7
Show member pathways
9.4CREB1, SRF
89.4CREB1, SRF
99.4CREB1, SRF
109.4CREB1, SRF
11
Show member pathways
9.4CREB1, SRF
129.4CREB1, SRF
13
Show member pathways
9.4SRF, CREB1
149.1CREB1, ALDH9A1
15
Show member pathways
9.1KCNK9, CREB1, BDNF
16
Show member pathways
9.1KCNK9, CREB1, BDNF
17
Show member pathways
mitochondrial L-carnitine shuttle pathway38
Saturated fatty acid biosynthesis60
9.0ALDH9A1, ADH6
18
Show member pathways
glycolysis38
gluconeogenesis38
Glycolysis and Gluconeogenesis38
9.0ADH6, ALDH9A1
19
Show member pathways
9.0BDNF, CREB1, SRF
20
Show member pathways
9.0SRF, CREB1, BDNF
21
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0BDNF, CREB1, SRF

Compounds for genes affiliated with Fetal Alcohol Spectrum Disorder

About this section

Compounds related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
13-nitropropionic acid459.9CREB1, BDNF
2quisqualate45 1310.9BDNF, CREB1
3antidepressants519.9BDNF, CREB1
4pilocarpine45 30 1311.9BDNF, SRF
5bisindolylmaleimide459.8BDNF, CREB1
6desipramine45 51 1311.8CREB1, BDNF
7methamphetamine45 51 1311.8CREB1, BDNF
8valproate459.8CREB1, BDNF
9risperidone45 51 30 61 26 1314.7CREB1, BDNF
106-hydroxydopamine459.7BDNF, CREB1
11fluoxetine45 51 30 1312.7BDNF, CREB1
12citalopram45 51 26 1312.6CREB1, BDNF
13dopac459.6BDNF, ALDH9A1
14daidzein459.5ALDH9A1, SRF
15betaine aldehyde45 2610.5ADH6, ALDH9A1
163a,7a-Dihydroxy-5b-cholestan-26-al269.4ADH6, ALDH9A1
17k252a459.4BDNF, CREB1, SRF
18dbc-amp459.4BDNF, CREB1, SRF
19imipramine45 30 51 26 1313.4BDNF, CREB1
20lysine459.4BDNF, SRF, KCNK9
21agar459.4SRF, CREB1, BDNF
22nmda45 3010.3BDNF, CREB1, SRF
23histamine45 30 2611.3BDNF, CREB1, SRF
24acetylcholine45 51 30 26 1313.3BDNF, CREB1, SRF
25estradiol45 26 1311.3BDNF, CREB1, SRF
26forskolin45 51 1311.3BDNF, CREB1, SRF
27acetaldehyde30 45 2611.3ADH6, ALDH9A1
28spermine30 45 26 1312.2ALDH9A1, SRF
29levodopa45 1310.1ALDH9A1, CREB1, BDNF
30gaba459.1BDNF, CREB1, ALDH9A1
31n acetylcysteine459.1ALDH9A1, CREB1, BDNF
324-hydroxynonenal45 2610.0CREB1, ALDH9A1, SRF
33retinoid459.0SRF, ALDH9A1, CREB1
34choline45 26 1311.0BDNF, ALDH9A1, ADH6
35cycloheximide459.0BDNF, CREB1, SRF
36dopamine45 30 26 1312.0BDNF, CREB1, ALDH9A1
37ethanol45 51 26 1311.9ADH6, ALDH9A1, BDNF
38genistein45 30 61 3 26 1313.9SRF, ALDH9A1, CREB1
39zinc45 269.8BDNF, CREB1, SRF, ADH6
40adenylate458.7ALDH9A1, CREB1, BDNF
41cyclic amp45 269.7BDNF, CREB1, SRF
42norepinephrine45 26 1310.6BDNF, CREB1, ALDH9A1, SRF
43lactate458.6SRF, ALDH9A1, CREB1, BDNF
44testosterone45 61 26 1311.6SRF, ALDH9A1, CREB1, BDNF
45retinoic acid45 269.5BDNF, CREB1, ALDH9A1, SRF
46lipid458.5SRF, ALDH9A1, CREB1, BDNF
47nadph45 269.5ADH6, SRF, ALDH9A1, BDNF
48vitamin a45 26 1310.4CREB1, ALDH9A1, SRF, ADH6
49serine458.3BDNF, CREB1, ALDH9A1, SRF
50glutamate458.2KCNK9, SRF, ALDH9A1, CREB1, BDNF

GO Terms for genes affiliated with Fetal Alcohol Spectrum Disorder

About this section

Cellular components related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:00080219.6BDNF, KCNK9

Biological processes related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:00016669.5BDNF, SRF
2response to hormoneGO:00097259.2BDNF, SRF

Molecular functions related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00037059.4CREB1, SRF
2protein homodimerization activityGO:00428038.4ALDH9A1, SRF, KCNK9

Products for genes affiliated with Fetal Alcohol Spectrum Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Fetal Alcohol Spectrum Disorder

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet