MCID: FTL006
MIFTS: 39

Fetal Alcohol Spectrum Disorder malady

Rare diseases, Neuronal diseases, Fetal diseases categories

Summaries for Fetal Alcohol Spectrum Disorder

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MedlinePlus:32 Alcohol can harm your baby at any stage during a pregnancy. that includes the earliest stages before you even know you are pregnant. drinking alcohol can cause a group of conditions called fetal alcohol spectrum disorders (fasds). effects can include physical and behavioral problems such as trouble with learning and remembering understanding and following directions controlling emotions communicating and socializing daily life skills, such as feeding and bathing fetal alcohol syndrome is the most serious type of fasd. people with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. fasds last a lifetime. there is no cure for fasds. treatments can help. these include medicines to help with some symptoms and behavior therapy. no one treatment is right for every child. centers for disease control and prevention

MalaCards based summary: Fetal Alcohol Spectrum Disorder, also known as fetal alcohol spectrum disorders, is related to alcohol abuse and fetal alcohol syndrome. An important gene associated with Fetal Alcohol Spectrum Disorder is KCNK9 (potassium channel, subfamily K, member 9), and among its related pathways are FSH signaling pathway and BDNF signaling pathway. The compounds 3-nitropropionic acid and quisqualate have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotypes are normal and respiratory system.

Disease Ontology:9 A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.

Wikipedia:63 Fetal (or foetal) alcohol spectrum disorders (FASD) is a continuum of various permanent birth defects... more...

Aliases & Classifications for Fetal Alcohol Spectrum Disorder

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Fetal Alcohol Spectrum Disorder, Aliases & Descriptions:

Name: Fetal Alcohol Spectrum Disorder 9 11
Fetal Alcohol Spectrum Disorders 41 32 60
Alcohol-Related Neurodevelopmental Disorder - Type 41
Alcohol-Related Birth Defects - Type 41
 
Fetal Alcohol Syndrome - Type 41
Fetal Alcohol Syndrome 60
Fasd 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:0050696

Related Diseases for Fetal Alcohol Spectrum Disorder

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Graphical network of the top 20 diseases related to Fetal Alcohol Spectrum Disorder:



Diseases related to fetal alcohol spectrum disorder

Symptoms for Fetal Alcohol Spectrum Disorder

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Drugs & Therapeutics for Fetal Alcohol Spectrum Disorder

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Drug clinical trials:

Search ClinicalTrials for Fetal Alcohol Spectrum Disorder

Search NIH Clinical Center for Fetal Alcohol Spectrum Disorder

Genetic Tests for Fetal Alcohol Spectrum Disorder

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Anatomical Context for Fetal Alcohol Spectrum Disorder

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MalaCards organs/tissues related to Fetal Alcohol Spectrum Disorder:

31
Eye, Brain, Testes, Cerebellum, Placenta

Animal Models for Fetal Alcohol Spectrum Disorder or affiliated genes

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MGI Mouse Phenotypes related to Fetal Alcohol Spectrum Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.6BDNF, CREB1, SRF, KCNK9
2MP:00053888.3BDNF, CREB1, SRF, KCNK9

Publications for Fetal Alcohol Spectrum Disorder

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Articles related to Fetal Alcohol Spectrum Disorder:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Verbal learning and memory impairment in children with fetal alcohol spectrum disorders. (25833031)
2015
2
Self-regulation therapy increases frontal gray matter in children with fetal alcohol spectrum disorder: evaluation by voxel-based morphometry. (25788884)
2015
3
The cost of lost productivity due to fetal alcohol spectrum disorder-related premature mortality. (25594934)
2015
4
Gene-specific disruption of endocannabinoid receptor 1 (cnr1a) by ethanol probably leads to the development of fetal alcohol spectrum disorder (FASD) phenotypes in Japanese rice fish (Oryzias latipes) embryogenesis. (25251458)
2014
5
Cognitive and Adaptive Skill Profile Differences in Children With Attention-Deficit Hyperactivity Disorder With and Without Comorbid Fetal Alcohol Spectrum Disorder. (25318015)
2014
6
Fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorder (FASD)-diagnosis and moral policing; an ethical dilemma for paediatricians. (25005521)
2014
7
Looking further upstream to prevent fetal alcohol spectrum disorder in Canada. (25560892)
2014
8
An animal model of fetal alcohol spectrum disorder: Trace conditioning as a window to inform memory deficits and intervention tactics. (25477227)
2014
9
Comparisons of Intelligence and Behavior in Children With Fetal Alcohol Spectrum Disorder and ADHD. (25525157)
2014
10
Costs of health services utilization of people with fetal alcohol spectrum disorder by sex and age group in Alberta, Canada. (25658807)
2014
11
Fetal alcohol spectrum disorder--poverty trap? (23458991)
2013
12
Clinical correlates of fetal alcohol spectrum disorder among diagnosed individuals in a rural diagnostic clinic. (24163155)
2013
13
Autism spectrum disorder and fetal alcohol spectrum disorder. Part II: a qualitative comparison of parenting stress. (23672659)
2013
14
Counting fetal alcohol spectrum disorder in Australia: the evidence and the challenges. (23617437)
2013
15
Inappropriate Feeding Behaviors and Dietary Intakes in Children with Fetal Alcohol Spectrum Disorder or Probable Prenatal Alcohol Exposure. (24164456)
2013
16
Altered accuracy of saccadic eye movements in children with fetal alcohol spectrum disorder. (23578065)
2013
17
Adopted children from the former Soviet Union: are they at risk of fetal alcohol spectrum disorder? (24130279)
2013
18
Identifying the neurobehavioral phenotype of fetal alcohol spectrum disorder in young children. (24163185)
2013
19
Sensory processing and ADHD in children with fetal alcohol spectrum disorder. (22439293)
2012
20
The effectiveness of a community-based intervention program for women at-risk for giving birth to a child with Fetal Alcohol Spectrum Disorder (FASD). (20694802)
2012
21
Glycosylation defects underlying fetal alcohol spectrum disorder: a novel pathogenetic model. "When the wine goes in, strange things come out" - S.T. Coleridge, The Piccolomini. (22134542)
2012
22
Sleep and sensory characteristics in young children with fetal alcohol spectrum disorder. (21654404)
2011
23
Diffusion tensor imaging of the cerebellum and eyeblink conditioning in fetal alcohol spectrum disorder. (21790667)
2011
24
Mental health issues in fetal alcohol spectrum disorder. (21780939)
2011
25
Changes in health professionals' knowledge, attitudes and practice following provision of educational resources about prevention of prenatal alcohol exposure and fetal alcohol spectrum disorder. (21649674)
2011
26
The Canadian guidelines and the interdisciplinary clinical capacity of Canada to diagnose fetal alcohol spectrum disorder. (22124027)
2011
27
Differentiating attention deficits in children with fetal alcohol spectrum disorder or attention-deficit-hyperactivity disorder. (19549201)
2010
28
Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disorders. (20164336)
2010
29
Alcohol-induced facial dysmorphology in C57BL/6 mouse models of fetal alcohol spectrum disorder. (20570474)
2010
30
The preventive effect of oral EGCG in a fetal alcohol spectrum disorder mouse model. (20659071)
2010
31
Concordance of three methods for palpebral fissure length measurement in the assessment of fetal alcohol spectrum disorder. (19372601)
2009
32
Fetal alcohol syndrome and fetal alcohol spectrum disorder in Indigenous schoolchildren. (19296803)
2009
33
Costs of fetal alcohol spectrum disorder in Alberta, Canada. (19151424)
2009
34
Fetal alcohol spectrum disorder(FASD. (20012791)
2009
35
Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migration. (19393862)
2009
36
Modulation of glutamatergic transmission by sulfated steroids: role in fetal alcohol spectrum disorder. (17597219)
2008
37
Acid-sensitive channel inhibition prevents fetal alcohol spectrum disorders cerebellar Purkinje cell loss. (18509098)
2008
38
Development of Canadian screening tools for fetal alcohol spectrum disorder. (18840921)
2008
39
Knowledge and attitudes of criminal justice professionals in relation to Fetal Alcohol Spectrum Disorder. (18678920)
2008
40
The effect of rehearsal training on working memory span of children with fetal alcohol spectrum disorder. (17317098)
2008
41
Re-examining the core features of autism: a comparison of autism spectrum disorder and fetal alcohol spectrum disorder. (17995487)
2007
42
Fetal alcohol spectrum disorder prevention approaches among Canadian physicians by proportion of Native/Aboriginal patients: practices during the preconception and prenatal periods. (17243020)
2007
43
Research-based interventions for children and youth with a Fetal Alcohol Spectrum Disorder: revealing the gap. (17584393)
2007
44
Knowledge and attitudes about fetal alcohol syndrome, fetal alcohol spectrum disorders, and alcohol use during pregnancy by occupational therapists in the Midwest. (19759993)
2007
45
Challenges of diagnosis in fetal alcohol syndrome and fetal alcohol spectrum disorder in the adult. (17640043)
2007
46
Persistence in high school: experiences of adolescents and young adults with Fetal Alcohol Spectrum Disorder. (17178534)
2006
47
Neurobehavioral functioning in children with fetal alcohol spectrum disorder. (16952890)
2006
48
Alcohol is a potent stimulant of immature neuronal networks: implications for fetal alcohol spectrum disorder. (16000153)
2005
49
Fetal alcohol spectrum disorder. (14638655)
2003
50
Fetal alcohol spectrum disorder - New diagnostic initiatives. (20046284)
2002

Variations for Fetal Alcohol Spectrum Disorder

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Expression for genes affiliated with Fetal Alcohol Spectrum Disorder

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Search GEO for disease gene expression data for Fetal Alcohol Spectrum Disorder.

Pathways for genes affiliated with Fetal Alcohol Spectrum Disorder

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Pathways related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CREB1, BDNF
29.5CREB1, BDNF
3
Show member pathways
Development ERBB family signaling58
Development GDNF family signaling58
9.5BDNF, CREB1
4
Show member pathways
9.5BDNF, CREB1
5
Show member pathways
9.5BDNF, CREB1
6
Show member pathways
9.4CREB1, SRF
7
Show member pathways
9.4CREB1, SRF
89.4CREB1, SRF
99.4CREB1, SRF
109.4CREB1, SRF
11
Show member pathways
9.4CREB1, SRF
129.4CREB1, SRF
13
Show member pathways
9.4SRF, CREB1
149.1CREB1, ALDH9A1
15
Show member pathways
9.1KCNK9, CREB1, BDNF
16
Show member pathways
9.1KCNK9, CREB1, BDNF
17
Show member pathways
mitochondrial L-carnitine shuttle pathway36
Saturated fatty acid biosynthesis58
9.0ALDH9A1, ADH6
18
Show member pathways
glycolysis36
gluconeogenesis36
Glycolysis and Gluconeogenesis36
9.0ADH6, ALDH9A1
19
Show member pathways
9.0BDNF, CREB1, SRF
20
Show member pathways
9.0SRF, CREB1, BDNF
21
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.0BDNF, CREB1, SRF

Compounds for genes affiliated with Fetal Alcohol Spectrum Disorder

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Compounds related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
13-nitropropionic acid439.9CREB1, BDNF
2quisqualate43 1210.9BDNF, CREB1
3antidepressants499.9BDNF, CREB1
4pilocarpine43 28 1211.9BDNF, SRF
5bisindolylmaleimide439.8BDNF, CREB1
6desipramine43 49 1211.8CREB1, BDNF
7methamphetamine43 49 1211.8CREB1, BDNF
8valproate439.8CREB1, BDNF
9risperidone43 49 28 59 24 1214.7CREB1, BDNF
106-hydroxydopamine439.7BDNF, CREB1
11fluoxetine43 49 28 1212.7BDNF, CREB1
12citalopram43 49 24 1212.6CREB1, BDNF
13dopac439.6BDNF, ALDH9A1
14daidzein439.5ALDH9A1, SRF
15betaine aldehyde43 2410.5ADH6, ALDH9A1
163a,7a-Dihydroxy-5b-cholestan-26-al249.4ADH6, ALDH9A1
17k252a439.4BDNF, CREB1, SRF
18dbc-amp439.4BDNF, CREB1, SRF
19imipramine43 28 49 24 1213.4BDNF, CREB1
20lysine439.4BDNF, SRF, KCNK9
21agar439.4SRF, CREB1, BDNF
22nmda43 2810.3BDNF, CREB1, SRF
23histamine43 28 2411.3BDNF, CREB1, SRF
24acetylcholine43 49 28 24 1213.3BDNF, CREB1, SRF
25estradiol43 24 1211.3BDNF, CREB1, SRF
26forskolin43 49 1211.3BDNF, CREB1, SRF
27acetaldehyde28 43 2411.3ADH6, ALDH9A1
28spermine28 43 24 1212.2ALDH9A1, SRF
29levodopa43 1210.1ALDH9A1, CREB1, BDNF
30gaba439.1BDNF, CREB1, ALDH9A1
31n acetylcysteine439.1ALDH9A1, CREB1, BDNF
324-hydroxynonenal43 2410.0CREB1, ALDH9A1, SRF
33retinoid439.0SRF, ALDH9A1, CREB1
34choline43 24 1211.0BDNF, ALDH9A1, ADH6
35cycloheximide439.0BDNF, CREB1, SRF
36dopamine43 28 24 1212.0BDNF, CREB1, ALDH9A1
37ethanol43 49 24 1211.9ADH6, ALDH9A1, BDNF
38genistein43 28 59 2 24 1213.9SRF, ALDH9A1, CREB1
39zinc43 249.8BDNF, CREB1, SRF, ADH6
40adenylate438.7ALDH9A1, CREB1, BDNF
41cyclic amp43 249.7BDNF, CREB1, SRF
42norepinephrine43 24 1210.6BDNF, CREB1, ALDH9A1, SRF
43lactate438.6SRF, ALDH9A1, CREB1, BDNF
44testosterone43 59 24 1211.6SRF, ALDH9A1, CREB1, BDNF
45retinoic acid43 249.5BDNF, CREB1, ALDH9A1, SRF
46lipid438.5SRF, ALDH9A1, CREB1, BDNF
47nadph43 249.5ADH6, SRF, ALDH9A1, BDNF
48vitamin a43 24 1210.4CREB1, ALDH9A1, SRF, ADH6
49serine438.3BDNF, CREB1, ALDH9A1, SRF
50glutamate438.2KCNK9, SRF, ALDH9A1, CREB1, BDNF

GO Terms for genes affiliated with Fetal Alcohol Spectrum Disorder

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Cellular components related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:00080219.6BDNF, KCNK9

Biological processes related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:00016669.5BDNF, SRF
2response to hormoneGO:00097259.2BDNF, SRF

Molecular functions related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00037059.4CREB1, SRF
2protein homodimerization activityGO:00428038.4ALDH9A1, SRF, KCNK9

Products for genes affiliated with Fetal Alcohol Spectrum Disorder

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Sources for Fetal Alcohol Spectrum Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet