FAS
MCID: FTL006
MIFTS: 60

Fetal Alcohol Spectrum Disorder (FAS) malady

Rare diseases, Fetal diseases, Neuronal diseases categories
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Summaries for Fetal Alcohol Spectrum Disorder

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MedlinePlus:33 Alcohol can harm your baby at any stage during a pregnancy. that includes the earliest stages before you even know you are pregnant. drinking alcohol can cause a group of conditions called fetal alcohol spectrum disorders (fasds). effects can include physical and behavioral problems such as trouble with learning and remembering understanding and following directions controlling emotions communicating and socializing daily life skills, such as feeding and bathing fetal alcohol syndrome is the most serious type of fasd. people with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. fasds last a lifetime. there is no cure for fasds. treatments can help. these include medicines to help with some symptoms and behavior therapy. no one treatment is right for every child. centers for disease control and prevention

MalaCards based summary: Fetal Alcohol Spectrum Disorder, also known as fetal alcohol spectrum disorders, is related to neuroblastoma and alcohol abuse, and has symptoms including microcephaly, narrow face and telecanthus/canthal dystopy. An important gene associated with Fetal Alcohol Spectrum Disorder is KCNK9 (potassium channel, subfamily K, member 9), and among its related pathways are FSH signaling pathway and BDNF signaling pathway. The compounds 3-nitropropionic acid and quisqualate have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and brain, and related mouse phenotypes are normal and respiratory system.

Disease Ontology:8 A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.

Wikipedia:65 Fetal (or foetal) alcohol spectrum disorders (FASD) is a continuum of various permanent birth defects... more...

Aliases & Classifications for Fetal Alcohol Spectrum Disorder

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Sources:
10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Fetal Alcohol Spectrum Disorder, Aliases & Descriptions:

Name: Fetal Alcohol Spectrum Disorder 8 10 62
Fetal Alcohol Spectrum Disorders 42 48 33 62
Fetal Alcohol Syndrome 10 44 48 62
Fasd 42 48 62
Alcohol-Related Neurodevelopmental Disorder 10 48
Alcohol-Related Birth Defects 48 62
Arnd 48 62
 
Arbd 48 62
Alcohol-Related Neurodevelopmental Disorder - Type 42
Alcohol Related Neurodevelopmental Disorder 62
Alcohol-Related Birth Defects - Type 42
Fetal Alcohol Syndrome - Type 42
Fas 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
fetal alcohol spectrum disorders:
Inheritance: Sporadic; Age of onset: Neonatal/infancy; Age of death: Any age


External Ids:

Disease Ontology8 DOID:0050696
MESH via Orphanet35 D005310
ICD10 via Orphanet26 Q86.0
UMLS via Orphanet63 C0015923
ICD1025 Q86.0

Related Diseases for Fetal Alcohol Spectrum Disorder

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Diseases in the Fetal Alcohol Spectrum Disorder family:

Fetal Alcohol Syndrome

Diseases related to Fetal Alcohol Spectrum Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 484)
idRelated DiseaseScoreTop Affiliating Genes
1neuroblastoma30.6BDNF
2alcohol abuse30.5CREB1, ALDH9A1
3lung cancer30.5CREB1, ALDH9A1, SRF
4systemic lupus erythematosus30.4SRF, CREB1, BDNF
5memory impairment30.3BDNF, CREB1
6rheumatoid arthritis30.3BDNF, CREB1, SRF
7adenocarcinoma30.2SRF, ALDH9A1, CREB1, BDNF
8alzheimer's disease30.0ALDH9A1, CREB1, BDNF
9huntington's disease29.7BDNF, CREB1
10liver cancer29.0BDNF, CREB1, ALDH9A1, SRF
11leukemia10.8
12hepatitis10.7
13thyroiditis10.7
14fetal alcohol syndrome10.7
15prostatitis10.7
16melanoma10.6
17autoimmune lymphoproliferative syndrome10.6
18breast cancer10.6
19hepatocellular carcinoma10.6
20attention deficit hyperactivity disorder10.6
21prostate cancer10.6
22lupus erythematosus10.5
23colon cancer10.5
24esophagitis10.5
25arthritis10.5
26myeloma10.5
27hepatitis c10.5
28pancreatitis10.5
29renal cell carcinoma10.5
30cervicitis10.5
31osteosarcoma10.5
32autoimmune lymphoproliferative syndrome, type ib10.5
33silicosis10.5
34gastric cancer10.4
35obesity10.4
36myeloid leukemia10.4
37autism spectrum disorder10.4
38hepatitis b10.4
39autoimmune thyroiditis10.4
40colorectal cancer10.4
41hiv-110.4
42alcohol dependence10.4ADH6
43multiple myeloma10.4
44t-cell leukemia10.4
45graft versus host disease10.4
46b-cell lymphomas10.4
47cervical cancer10.4
48ovarian cancer10.4
49cholangiocarcinoma10.3
50cutaneous t cell lymphoma10.3

Graphical network of the top 20 diseases related to Fetal Alcohol Spectrum Disorder:



Diseases related to fetal alcohol spectrum disorder

Symptoms for Fetal Alcohol Spectrum Disorder

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Symptoms:

48 (show all 31)
  • microcephaly
  • narrow face
  • telecanthus/canthal dystopy
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • psychic/behavioural troubles
  • short stature/dwarfism/nanism
  • intrauterine growth retardation
  • antenatal exposure : alcohol
  • narrow forehead
  • micrognathia/retrognathia/micrognathism/retrognathism
  • anophthalmos/anophthalmia/microphthalmos/microphthalmia
  • strabismus/squint
  • ptosis
  • epicanthic folds
  • short/small nose
  • anteverted nares/nostrils
  • thin/retracted lips
  • philtrum flat/large/featureless/absent cupidon bows
  • lateral cleft lip/gingival cleft/paramedian nasal cleft
  • complete/partial microdontia
  • low set ears/posteriorly rotated ears
  • vertebral segmentation anomaly/hemivertebrae
  • abnormal dermatoglyphics
  • atrial septal defect/interauricular communication
  • visceral angiomatosis (excluding skin)
  • restricted joint mobility/joint stiffness/ankylosis
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • cleft palate without cleft lip/submucosal cleft palate/bifid uvula
  • hirsutism/hypertrichosis/increased body hair
  • diaphragmatic hernia/defect/agenesis
  • stillbirth/neonatal death

HPO human phenotypes related to Fetal Alcohol Spectrum Disorder:

(show all 29)
id Description Frequency HPO Source Accession
1 microcephaly hallmark (90%) HP:0000252
2 narrow face hallmark (90%) HP:0000275
3 telecanthus hallmark (90%) HP:0000506
4 behavioral abnormality hallmark (90%) HP:0000708
5 intrauterine growth retardation hallmark (90%) HP:0001511
6 short stature hallmark (90%) HP:0004322
7 cognitive impairment hallmark (90%) HP:0100543
8 thin vermilion border typical (50%) HP:0000233
9 epicanthus typical (50%) HP:0000286
10 abnormality of the philtrum typical (50%) HP:0000288
11 narrow forehead typical (50%) HP:0000341
12 micrognathia typical (50%) HP:0000347
13 low-set, posteriorly rotated ears typical (50%) HP:0000368
14 anteverted nares typical (50%) HP:0000463
15 strabismus typical (50%) HP:0000486
16 ptosis typical (50%) HP:0000508
17 microdontia typical (50%) HP:0000691
18 limitation of joint mobility typical (50%) HP:0001376
19 defect in the atrial septum typical (50%) HP:0001631
20 short nose typical (50%) HP:0003196
21 vertebral segmentation defect typical (50%) HP:0003422
22 abnormal dermatoglyphics typical (50%) HP:0007477
23 aplasia/hypoplasia affecting the eye typical (50%) HP:0008056
24 abnormality of immune system physiology typical (50%) HP:0010978
25 non-midline cleft lip typical (50%) HP:0100335
26 visceral angiomatosis typical (50%) HP:0100761
27 cleft palate occasional (7.5%) HP:0000175
28 congenital diaphragmatic hernia occasional (7.5%) HP:0000776
29 hypertrichosis occasional (7.5%) HP:0000998

Drugs & Therapeutics for Fetal Alcohol Spectrum Disorder

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Drug clinical trials:

Search ClinicalTrials for Fetal Alcohol Spectrum Disorder

Search NIH Clinical Center for Fetal Alcohol Spectrum Disorder

Genetic Tests for Fetal Alcohol Spectrum Disorder

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Anatomical Context for Fetal Alcohol Spectrum Disorder

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MalaCards organs/tissues related to Fetal Alcohol Spectrum Disorder:

32
Eye, Skin, Brain, Cerebellum, Placenta, Testes

Animal Models for Fetal Alcohol Spectrum Disorder or affiliated genes

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MGI Mouse Phenotypes related to Fetal Alcohol Spectrum Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.6BDNF, CREB1, SRF, KCNK9
2MP:00053888.3BDNF, CREB1, SRF, KCNK9

Publications for Fetal Alcohol Spectrum Disorder

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Articles related to Fetal Alcohol Spectrum Disorder:

(show top 50)    (show all 150)
idTitleAuthorsYear
1
Gene-specific disruption of endocannabinoid receptor 1 (cnr1a) by ethanol probably leads to the development of fetal alcohol spectrum disorder (FASD) phenotypes in Japanese rice fish (Oryzias latipes) embryogenesis. (25251458)
2014
2
Cognitive and Adaptive Skill Profile Differences in Children With Attention-Deficit Hyperactivity Disorder With and Without Comorbid Fetal Alcohol Spectrum Disorder. (25318015)
2014
3
Fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorder (FASD)-diagnosis and moral policing; an ethical dilemma for paediatricians. (25005521)
2014
4
Fetal alcohol spectrum disorder--poverty trap? (23458991)
2013
5
Clinical correlates of fetal alcohol spectrum disorder among diagnosed individuals in a rural diagnostic clinic. (24163155)
2013
6
Autism spectrum disorder and fetal alcohol spectrum disorder. Part II: a qualitative comparison of parenting stress. (23672659)
2013
7
Counting fetal alcohol spectrum disorder in Australia: the evidence and the challenges. (23617437)
2013
8
Inappropriate Feeding Behaviors and Dietary Intakes in Children with Fetal Alcohol Spectrum Disorder or Probable Prenatal Alcohol Exposure. (24164456)
2013
9
Altered accuracy of saccadic eye movements in children with fetal alcohol spectrum disorder. (23578065)
2013
10
Adopted children from the former Soviet Union: are they at risk of fetal alcohol spectrum disorder? (24130279)
2013
11
Identifying the neurobehavioral phenotype of fetal alcohol spectrum disorder in young children. (24163185)
2013
12
Diffusion tensor imaging correlates of saccadic reaction time in children with fetal alcohol spectrum disorder. (23551175)
2013
13
Evaluating the Psycholegal Abilities of Young Offenders With Fetal Alcohol Spectrum Disorder. (23834387)
2013
14
Sensory processing and ADHD in children with fetal alcohol spectrum disorder. (22439293)
2012
15
The effectiveness of a community-based intervention program for women at-risk for giving birth to a child with Fetal Alcohol Spectrum Disorder (FASD). (20694802)
2012
16
Glycosylation defects underlying fetal alcohol spectrum disorder: a novel pathogenetic model. "When the wine goes in, strange things come out" - S.T. Coleridge, The Piccolomini. (22134542)
2012
17
Ethical considerations when communicating a diagnosis of a fetal alcohol spectrum disorder to a child. (23077138)
2012
18
Sleep and sensory characteristics in young children with fetal alcohol spectrum disorder. (21654404)
2011
19
Diffusion tensor imaging of the cerebellum and eyeblink conditioning in fetal alcohol spectrum disorder. (21790667)
2011
20
Mental health issues in fetal alcohol spectrum disorder. (21780939)
2011
21
Changes in health professionals' knowledge, attitudes and practice following provision of educational resources about prevention of prenatal alcohol exposure and fetal alcohol spectrum disorder. (21649674)
2011
22
The Canadian guidelines and the interdisciplinary clinical capacity of Canada to diagnose fetal alcohol spectrum disorder. (22124027)
2011
23
Paediatricians' knowledge, attitudes and practice following provision of educational resources about prevention of prenatal alcohol exposure and Fetal Alcohol Spectrum Disorder. (21449899)
2011
24
Differentiating attention deficits in children with fetal alcohol spectrum disorder or attention-deficit-hyperactivity disorder. (19549201)
2010
25
Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disorders. (20164336)
2010
26
Alcohol-induced facial dysmorphology in C57BL/6 mouse models of fetal alcohol spectrum disorder. (20570474)
2010
27
The preventive effect of oral EGCG in a fetal alcohol spectrum disorder mouse model. (20659071)
2010
28
Concordance of three methods for palpebral fissure length measurement in the assessment of fetal alcohol spectrum disorder. (19372601)
2009
29
Fetal alcohol syndrome and fetal alcohol spectrum disorder in Indigenous schoolchildren. (19296803)
2009
30
Costs of fetal alcohol spectrum disorder in Alberta, Canada. (19151424)
2009
31
Fetal alcohol spectrum disorder(FASD. (20012791)
2009
32
Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migration. (19393862)
2009
33
Diagnosing fetal alcohol spectrum disorder: History, challenges and future directions. (20357921)
2009
34
Modulation of glutamatergic transmission by sulfated steroids: role in fetal alcohol spectrum disorder. (17597219)
2008
35
Acid-sensitive channel inhibition prevents fetal alcohol spectrum disorders cerebellar Purkinje cell loss. (18509098)
2008
36
Development of Canadian screening tools for fetal alcohol spectrum disorder. (18840921)
2008
37
Knowledge and attitudes of criminal justice professionals in relation to Fetal Alcohol Spectrum Disorder. (18678920)
2008
38
The effect of rehearsal training on working memory span of children with fetal alcohol spectrum disorder. (17317098)
2008
39
Re-examining the core features of autism: a comparison of autism spectrum disorder and fetal alcohol spectrum disorder. (17995487)
2007
40
Fetal alcohol spectrum disorder prevention approaches among Canadian physicians by proportion of Native/Aboriginal patients: practices during the preconception and prenatal periods. (17243020)
2007
41
Research-based interventions for children and youth with a Fetal Alcohol Spectrum Disorder: revealing the gap. (17584393)
2007
42
Knowledge and attitudes about fetal alcohol syndrome, fetal alcohol spectrum disorders, and alcohol use during pregnancy by occupational therapists in the Midwest. (19759993)
2007
43
Challenges of diagnosis in fetal alcohol syndrome and fetal alcohol spectrum disorder in the adult. (17640043)
2007
44
A state of double jeopardy: impact of prenatal alcohol exposure and adverse environments on the social communicative abilities of school-age children with fetal alcohol spectrum disorder. (17428958)
2007
45
Persistence in high school: experiences of adolescents and young adults with Fetal Alcohol Spectrum Disorder. (17178534)
2006
46
Neurobehavioral functioning in children with fetal alcohol spectrum disorder. (16952890)
2006
47
Alcohol is a potent stimulant of immature neuronal networks: implications for fetal alcohol spectrum disorder. (16000153)
2005
48
Fetal alcohol spectrum disorder. (14638655)
2003
49
Fetal alcohol spectrum disorder - New diagnostic initiatives. (20046284)
2002
50
Clinical implications of a link between fetal alcohol spectrum disorder and attention-deficit hyperactivity disorder. (12025433)
2002

Variations for Fetal Alcohol Spectrum Disorder

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Expression for genes affiliated with Fetal Alcohol Spectrum Disorder

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Expression patterns in normal tissues for genes affiliated with Fetal Alcohol Spectrum Disorder

Search GEO for disease gene expression data for Fetal Alcohol Spectrum Disorder.

Pathways for genes affiliated with Fetal Alcohol Spectrum Disorder

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Pathways related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CREB1, BDNF
29.5CREB1, BDNF
3
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.5BDNF, CREB1
4
Show member pathways
9.5BDNF, CREB1
5
Show member pathways
9.5BDNF, CREB1
6
Show member pathways
9.4CREB1, SRF
7
Show member pathways
9.4CREB1, SRF
89.4CREB1, SRF
99.4CREB1, SRF
109.4CREB1, SRF
11
Show member pathways
9.4CREB1, SRF
129.4CREB1, SRF
13
Show member pathways
9.4SRF, CREB1
149.1CREB1, ALDH9A1
15
Show member pathways
9.1KCNK9, CREB1, BDNF
16
Show member pathways
9.1KCNK9, CREB1, BDNF
17
Show member pathways
mitochondrial L-carnitine shuttle pathway37
Saturated fatty acid biosynthesis60
9.0ALDH9A1, ADH6
18
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
9.0ADH6, ALDH9A1
19
Show member pathways
9.0BDNF, CREB1, SRF
20
Show member pathways
9.0SRF, CREB1, BDNF
21
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0BDNF, CREB1, SRF

Compounds for genes affiliated with Fetal Alcohol Spectrum Disorder

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Compounds related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
13-nitropropionic acid449.9CREB1, BDNF
2quisqualate44 1110.9BDNF, CREB1
3antidepressants509.9BDNF, CREB1
4pilocarpine44 28 1111.9BDNF, SRF
5bisindolylmaleimide449.8BDNF, CREB1
6desipramine44 50 1111.8CREB1, BDNF
7methamphetamine44 50 1111.8CREB1, BDNF
8valproate449.8CREB1, BDNF
9risperidone44 50 28 61 24 1114.7CREB1, BDNF
106-hydroxydopamine449.7BDNF, CREB1
11fluoxetine44 50 28 1112.7BDNF, CREB1
12citalopram44 50 24 1112.6CREB1, BDNF
13dopac449.6BDNF, ALDH9A1
14daidzein449.5ALDH9A1, SRF
15betaine aldehyde44 2410.5ADH6, ALDH9A1
163a,7a-Dihydroxy-5b-cholestan-26-al249.4ADH6, ALDH9A1
17k252a449.4BDNF, CREB1, SRF
18dbc-amp449.4BDNF, CREB1, SRF
19imipramine44 28 50 24 1113.4BDNF, CREB1
20lysine449.4BDNF, SRF, KCNK9
21agar449.4SRF, CREB1, BDNF
22nmda44 2810.3BDNF, CREB1, SRF
23histamine44 28 2411.3BDNF, CREB1, SRF
24acetylcholine44 50 28 24 1113.3BDNF, CREB1, SRF
25estradiol44 24 1111.3BDNF, CREB1, SRF
26forskolin44 50 1111.3BDNF, CREB1, SRF
27acetaldehyde28 44 2411.3ADH6, ALDH9A1
28spermine28 44 24 1112.2ALDH9A1, SRF
29levodopa44 1110.1ALDH9A1, CREB1, BDNF
30gaba449.1BDNF, CREB1, ALDH9A1
31n acetylcysteine449.1ALDH9A1, CREB1, BDNF
324-hydroxynonenal44 2410.0CREB1, ALDH9A1, SRF
33retinoid449.0SRF, ALDH9A1, CREB1
34choline44 24 1111.0BDNF, ALDH9A1, ADH6
35cycloheximide449.0BDNF, CREB1, SRF
36dopamine44 28 24 1112.0BDNF, CREB1, ALDH9A1
37ethanol44 50 24 1111.9ADH6, ALDH9A1, BDNF
38genistein44 28 61 2 24 1113.9SRF, ALDH9A1, CREB1
39zinc44 249.8BDNF, CREB1, SRF, ADH6
40adenylate448.7ALDH9A1, CREB1, BDNF
41cyclic amp44 249.7BDNF, CREB1, SRF
42norepinephrine44 24 1110.6BDNF, CREB1, ALDH9A1, SRF
43lactate448.6SRF, ALDH9A1, CREB1, BDNF
44testosterone44 61 24 1111.6SRF, ALDH9A1, CREB1, BDNF
45retinoic acid44 249.5BDNF, CREB1, ALDH9A1, SRF
46lipid448.5SRF, ALDH9A1, CREB1, BDNF
47nadph44 249.5ADH6, SRF, ALDH9A1, BDNF
48vitamin a44 24 1110.4CREB1, ALDH9A1, SRF, ADH6
49serine448.3BDNF, CREB1, ALDH9A1, SRF
50glutamate448.2KCNK9, SRF, ALDH9A1, CREB1, BDNF

GO Terms for genes affiliated with Fetal Alcohol Spectrum Disorder

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Cellular components related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:0080219.6BDNF, KCNK9

Biological processes related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:0016669.5BDNF, SRF
2response to hormoneGO:0097259.2BDNF, SRF

Molecular functions related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:0037059.4CREB1, SRF
2protein homodimerization activityGO:0428038.4ALDH9A1, SRF, KCNK9

Products for genes affiliated with Fetal Alcohol Spectrum Disorder

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Sources for Fetal Alcohol Spectrum Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet