MCID: FTL006
MIFTS: 39

Fetal Alcohol Spectrum Disorder malady

Rare diseases, Neuronal diseases, Fetal diseases categories

Aliases & Classifications for Fetal Alcohol Spectrum Disorder

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Aliases & Descriptions for Fetal Alcohol Spectrum Disorder:

Name: Fetal Alcohol Spectrum Disorder 8 10
Fetal Alcohol Spectrum Disorders 42 32 61
Alcohol-Related Neurodevelopmental Disorder - Type 42
Alcohol-Related Birth Defects - Type 42
 
Fetal Alcohol Syndrome - Type 42
Fetal Alcohol Syndrome 61
Fasd 42


Classifications:



External Ids:

Disease Ontology8 DOID:0050696

Summaries for Fetal Alcohol Spectrum Disorder

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MedlinePlus:32 Alcohol can harm your baby at any stage during a pregnancy. that includes the earliest stages before you even know you are pregnant. drinking alcohol can cause a group of conditions called fetal alcohol spectrum disorders (fasds). effects can include physical and behavioral problems such as trouble with learning and remembering understanding and following directions controlling emotions communicating and socializing daily life skills, such as feeding and bathing fetal alcohol syndrome is the most serious type of fasd. people with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. fasds last a lifetime. there is no cure for fasds. treatments can help. these include medicines to help with some symptoms and behavior therapy. no one treatment is right for every child. centers for disease control and prevention

MalaCards based summary: Fetal Alcohol Spectrum Disorder, also known as fetal alcohol spectrum disorders, is related to alcohol abuse and fetal alcohol syndrome. An important gene associated with Fetal Alcohol Spectrum Disorder is KCNK9 (potassium channel, subfamily K, member 9), and among its related pathways are FSH signaling pathway and BDNF signaling pathway. The compounds 3-nitropropionic acid and antidepressants have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotypes are normal and respiratory system.

Disease Ontology:8 A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.

Wikipedia:64 Fetal (or foetal) alcohol spectrum disorders (FASD) is a continuum of various permanent birth defects... more...

Related Diseases for Fetal Alcohol Spectrum Disorder

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Graphical network of the top 20 diseases related to Fetal Alcohol Spectrum Disorder:



Diseases related to fetal alcohol spectrum disorder

Symptoms for Fetal Alcohol Spectrum Disorder

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Drugs & Therapeutics for Fetal Alcohol Spectrum Disorder

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Drug clinical trials:

Search ClinicalTrials for Fetal Alcohol Spectrum Disorder

Search NIH Clinical Center for Fetal Alcohol Spectrum Disorder

Genetic Tests for Fetal Alcohol Spectrum Disorder

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Anatomical Context for Fetal Alcohol Spectrum Disorder

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MalaCards organs/tissues related to Fetal Alcohol Spectrum Disorder:

31
Eye, Brain, Testes, Cerebellum, Placenta

Animal Models for Fetal Alcohol Spectrum Disorder or affiliated genes

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MGI Mouse Phenotypes related to Fetal Alcohol Spectrum Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.6BDNF, CREB1, SRF, KCNK9
2MP:00053888.3BDNF, CREB1, SRF, KCNK9

Publications for Fetal Alcohol Spectrum Disorder

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Articles related to Fetal Alcohol Spectrum Disorder:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Verbal learning and memory impairment in children with fetal alcohol spectrum disorders. (25833031)
2015
2
Self-regulation therapy increases frontal gray matter in children with fetal alcohol spectrum disorder: evaluation by voxel-based morphometry. (25788884)
2015
3
The cost of lost productivity due to fetal alcohol spectrum disorder-related premature mortality. (25594934)
2015
4
Gene-specific disruption of endocannabinoid receptor 1 (cnr1a) by ethanol probably leads to the development of fetal alcohol spectrum disorder (FASD) phenotypes in Japanese rice fish (Oryzias latipes) embryogenesis. (25251458)
2014
5
Cognitive and Adaptive Skill Profile Differences in Children With Attention-Deficit Hyperactivity Disorder With and Without Comorbid Fetal Alcohol Spectrum Disorder. (25318015)
2014
6
Fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorder (FASD)-diagnosis and moral policing; an ethical dilemma for paediatricians. (25005521)
2014
7
Looking further upstream to prevent fetal alcohol spectrum disorder in Canada. (25560892)
2014
8
An animal model of fetal alcohol spectrum disorder: Trace conditioning as a window to inform memory deficits and intervention tactics. (25477227)
2014
9
Comparisons of Intelligence and Behavior in Children With Fetal Alcohol Spectrum Disorder and ADHD. (25525157)
2014
10
Costs of health services utilization of people with fetal alcohol spectrum disorder by sex and age group in Alberta, Canada. (25658807)
2014
11
Fetal alcohol spectrum disorder--poverty trap? (23458991)
2013
12
Clinical correlates of fetal alcohol spectrum disorder among diagnosed individuals in a rural diagnostic clinic. (24163155)
2013
13
Autism spectrum disorder and fetal alcohol spectrum disorder. Part II: a qualitative comparison of parenting stress. (23672659)
2013
14
Counting fetal alcohol spectrum disorder in Australia: the evidence and the challenges. (23617437)
2013
15
Inappropriate Feeding Behaviors and Dietary Intakes in Children with Fetal Alcohol Spectrum Disorder or Probable Prenatal Alcohol Exposure. (24164456)
2013
16
Altered accuracy of saccadic eye movements in children with fetal alcohol spectrum disorder. (23578065)
2013
17
Adopted children from the former Soviet Union: are they at risk of fetal alcohol spectrum disorder? (24130279)
2013
18
Identifying the neurobehavioral phenotype of fetal alcohol spectrum disorder in young children. (24163185)
2013
19
Sensory processing and ADHD in children with fetal alcohol spectrum disorder. (22439293)
2012
20
The effectiveness of a community-based intervention program for women at-risk for giving birth to a child with Fetal Alcohol Spectrum Disorder (FASD). (20694802)
2012
21
Glycosylation defects underlying fetal alcohol spectrum disorder: a novel pathogenetic model. "When the wine goes in, strange things come out" - S.T. Coleridge, The Piccolomini. (22134542)
2012
22
Sleep and sensory characteristics in young children with fetal alcohol spectrum disorder. (21654404)
2011
23
Diffusion tensor imaging of the cerebellum and eyeblink conditioning in fetal alcohol spectrum disorder. (21790667)
2011
24
Mental health issues in fetal alcohol spectrum disorder. (21780939)
2011
25
Changes in health professionals' knowledge, attitudes and practice following provision of educational resources about prevention of prenatal alcohol exposure and fetal alcohol spectrum disorder. (21649674)
2011
26
The Canadian guidelines and the interdisciplinary clinical capacity of Canada to diagnose fetal alcohol spectrum disorder. (22124027)
2011
27
Differentiating attention deficits in children with fetal alcohol spectrum disorder or attention-deficit-hyperactivity disorder. (19549201)
2010
28
Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disorders. (20164336)
2010
29
Alcohol-induced facial dysmorphology in C57BL/6 mouse models of fetal alcohol spectrum disorder. (20570474)
2010
30
The preventive effect of oral EGCG in a fetal alcohol spectrum disorder mouse model. (20659071)
2010
31
Concordance of three methods for palpebral fissure length measurement in the assessment of fetal alcohol spectrum disorder. (19372601)
2009
32
Fetal alcohol syndrome and fetal alcohol spectrum disorder in Indigenous schoolchildren. (19296803)
2009
33
Costs of fetal alcohol spectrum disorder in Alberta, Canada. (19151424)
2009
34
Fetal alcohol spectrum disorder(FASD. (20012791)
2009
35
Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migration. (19393862)
2009
36
Modulation of glutamatergic transmission by sulfated steroids: role in fetal alcohol spectrum disorder. (17597219)
2008
37
Acid-sensitive channel inhibition prevents fetal alcohol spectrum disorders cerebellar Purkinje cell loss. (18509098)
2008
38
Development of Canadian screening tools for fetal alcohol spectrum disorder. (18840921)
2008
39
Knowledge and attitudes of criminal justice professionals in relation to Fetal Alcohol Spectrum Disorder. (18678920)
2008
40
The effect of rehearsal training on working memory span of children with fetal alcohol spectrum disorder. (17317098)
2008
41
Re-examining the core features of autism: a comparison of autism spectrum disorder and fetal alcohol spectrum disorder. (17995487)
2007
42
Fetal alcohol spectrum disorder prevention approaches among Canadian physicians by proportion of Native/Aboriginal patients: practices during the preconception and prenatal periods. (17243020)
2007
43
Research-based interventions for children and youth with a Fetal Alcohol Spectrum Disorder: revealing the gap. (17584393)
2007
44
Knowledge and attitudes about fetal alcohol syndrome, fetal alcohol spectrum disorders, and alcohol use during pregnancy by occupational therapists in the Midwest. (19759993)
2007
45
Challenges of diagnosis in fetal alcohol syndrome and fetal alcohol spectrum disorder in the adult. (17640043)
2007
46
Persistence in high school: experiences of adolescents and young adults with Fetal Alcohol Spectrum Disorder. (17178534)
2006
47
Neurobehavioral functioning in children with fetal alcohol spectrum disorder. (16952890)
2006
48
Alcohol is a potent stimulant of immature neuronal networks: implications for fetal alcohol spectrum disorder. (16000153)
2005
49
Fetal alcohol spectrum disorder. (14638655)
2003
50
Fetal alcohol spectrum disorder - New diagnostic initiatives. (20046284)
2002

Variations for Fetal Alcohol Spectrum Disorder

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Expression for genes affiliated with Fetal Alcohol Spectrum Disorder

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Search GEO for disease gene expression data for Fetal Alcohol Spectrum Disorder.

Pathways for genes affiliated with Fetal Alcohol Spectrum Disorder

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Pathways related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CREB1, BDNF
29.5CREB1, BDNF
3
Show member pathways
Development ERBB family signaling59
Development GDNF family signaling59
9.5BDNF, CREB1
4
Show member pathways
9.5BDNF, CREB1
5
Show member pathways
9.5BDNF, CREB1
6
Show member pathways
9.4CREB1, SRF
7
Show member pathways
9.4CREB1, SRF
89.4CREB1, SRF
99.4CREB1, SRF
109.4CREB1, SRF
11
Show member pathways
9.4CREB1, SRF
129.4CREB1, SRF
13
Show member pathways
9.4SRF, CREB1
149.1CREB1, ALDH9A1
15
Show member pathways
9.1KCNK9, CREB1, BDNF
16
Show member pathways
9.1KCNK9, CREB1, BDNF
17
Show member pathways
mitochondrial L-carnitine shuttle pathway36
Saturated fatty acid biosynthesis59
9.0ALDH9A1, ADH6
18
Show member pathways
glycolysis36
gluconeogenesis36
Glycolysis and Gluconeogenesis36
9.0ADH6, ALDH9A1
19
Show member pathways
9.0BDNF, CREB1, SRF
20
Show member pathways
9.0SRF, CREB1, BDNF
21
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
9.0BDNF, CREB1, SRF

Compounds for genes affiliated with Fetal Alcohol Spectrum Disorder

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Compounds related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
13-nitropropionic acid449.9CREB1, BDNF
2antidepressants509.9CREB1, BDNF
3quisqualate44 1110.9BDNF, CREB1
4pilocarpine44 28 1111.9BDNF, SRF
5bisindolylmaleimide449.8CREB1, BDNF
6desipramine44 50 1111.8BDNF, CREB1
7methamphetamine44 50 1111.8BDNF, CREB1
8valproate449.8CREB1, BDNF
9risperidone44 50 28 60 24 1114.7BDNF, CREB1
106-hydroxydopamine449.7CREB1, BDNF
11fluoxetine44 50 28 1112.7CREB1, BDNF
12citalopram44 50 24 1112.6CREB1, BDNF
13dopac449.6BDNF, ALDH9A1
14daidzein449.5SRF, ALDH9A1
15betaine aldehyde44 2410.5ALDH9A1, ADH6
163a,7a-Dihydroxy-5b-cholestan-26-al249.4ALDH9A1, ADH6
17k252a449.4SRF, BDNF, CREB1
18dbc-amp449.4CREB1, SRF, BDNF
19lysine449.4KCNK9, BDNF, SRF
20agar449.4SRF, BDNF, CREB1
21nmda44 2810.3BDNF, CREB1, SRF
22histamine44 28 2411.3SRF, CREB1, BDNF
23acetylcholine44 50 28 24 1113.3CREB1, SRF, BDNF
24estradiol44 24 1111.3SRF, CREB1, BDNF
25forskolin44 50 1111.3SRF, BDNF, CREB1
26acetaldehyde28 44 2411.3ALDH9A1, ADH6
27imipramine44 28 50 24 1113.2BDNF, CREB1
28spermine28 44 24 1112.2SRF, ALDH9A1
29levodopa44 1110.1BDNF, CREB1, ALDH9A1
30gaba449.1BDNF, ALDH9A1, CREB1
31n acetylcysteine449.1BDNF, CREB1, ALDH9A1
324-hydroxynonenal44 2410.0ALDH9A1, CREB1, SRF
33retinoid449.0SRF, ALDH9A1, CREB1
34choline44 24 1111.0BDNF, ALDH9A1, ADH6
35cycloheximide449.0BDNF, CREB1, SRF
36dopamine44 28 24 1112.0BDNF, CREB1, ALDH9A1
37ethanol44 50 24 1111.9BDNF, ALDH9A1, ADH6
38genistein44 28 60 1 24 1113.9SRF, ALDH9A1, CREB1
39cyclic amp44 249.9BDNF, CREB1, SRF
40zinc44 249.8SRF, ADH6, BDNF, CREB1
41adenylate448.7CREB1, BDNF, ALDH9A1
42norepinephrine44 24 1110.6BDNF, SRF, ALDH9A1, CREB1
43lactate448.6CREB1, ALDH9A1, SRF, BDNF
44testosterone44 60 24 1111.6CREB1, BDNF, ALDH9A1, SRF
45retinoic acid44 249.5CREB1, ALDH9A1, BDNF, SRF
46lipid448.5CREB1, BDNF, ALDH9A1, SRF
47nadph44 249.5SRF, ADH6, BDNF, ALDH9A1
48vitamin a44 24 1110.4SRF, ALDH9A1, ADH6, CREB1
49serine448.3ALDH9A1, CREB1, BDNF, SRF
50glutamate448.2ALDH9A1, SRF, KCNK9, BDNF, CREB1

GO Terms for genes affiliated with Fetal Alcohol Spectrum Disorder

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Cellular components related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:00080219.6BDNF, KCNK9

Biological processes related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:00016669.5BDNF, SRF
2response to hormoneGO:00097259.2BDNF, SRF

Molecular functions related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00037059.4CREB1, SRF
2protein homodimerization activityGO:00428038.4ALDH9A1, SRF, KCNK9

Sources for Fetal Alcohol Spectrum Disorder

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet