FASD
MCID: FTL006
MIFTS: 58

Fetal Alcohol Spectrum Disorder (FASD) malady

Fetal diseases, Neuronal diseases categories

Summaries for Fetal Alcohol Spectrum Disorder

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Alcohol can harm your baby at any stage during a pregnancy. that includes the earliest stages before you even know you are pregnant. drinking alcohol can cause a group of conditions called fetal alcohol spectrum disorders (fasds).effects can include physical and behavioral problems such as trouble with learning and remembering understanding and following directions controlling emotions communicating and socializing daily life skills, such as feeding and bathing fetal alcohol syndrome is the most serious type of fasd. people with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. fasds last a lifetime. there is no cure for fasds. treatments can help. these include medicines to help with some symptoms and behavior therapy. no one treatment is right for every child. centers for disease control and prevention

MalaCards: Fetal Alcohol Spectrum Disorder, also known as fetal alcohol syndrome, is related to alcohol abuse and alcohol dependence, and has symptoms including low set ears/posteriorly rotated ears, vertebral segmentation anomaly/hemivertebrae and abnormal dermatoglyphics. An important gene associated with Fetal Alcohol Spectrum Disorder is KCNK9 (potassium channel, subfamily K, member 9), and among its related pathways are FSH signaling pathway and Validated targets of C-MYC transcriptional repression. The drugs chlordiazepoxide and citalopram and the compounds 3-nitropropionic acid and antidepressants have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and brain, and related mouse phenotypes are normal and respiratory system.

Disease Ontology:8 A physical disorder that involves physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.

Wikipedia:63 Fetal alcohol spectrum disorders (FASD) is an umbrella term which describes a continuum of permanent... more...

Aliases & Classifications for Fetal Alcohol Spectrum Disorder

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Sources:
10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
fetal alcohol syndrome:
Inheritance: Sporadic; Age of onset: Neonatal/infancy; Age of death: Any age


Aliases & Descriptions:

fetal alcohol spectrum disorder 8 10 60
fetal alcohol syndrome 10 44 48 60
fetal alcohol spectrum disorders 42 33
alcohol-related neurodevelopmental disorder - type 42
alcohol-related neurodevelopmental disorder 10
alcohol related neurodevelopmental disorder 60
alcohol-related birth defects - type 42
fetal alcohol syndrome - type 42
alcoholic intoxication, chronic 60
alcohol antenatal infection 48
fasd 42


External Ids:

Disease Ontology8 DOID:0050696
MESH via Orphanet35 D005310
ICD10 via Orphanet26 Q86.0
SNOMED-CT via Orphanet57 205788004
UMLS via Orphanet61 C0015923
ICD1025 Q86.0

Related Diseases for Fetal Alcohol Spectrum Disorder

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Fetal Alcohol Spectrum Disorder family:

Fetal Alcohol Syndrome

Diseases related to Fetal Alcohol Spectrum Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol abuse30.4CREB1, ALDH9A1
2alcohol dependence30.2ADH6
3down syndrome30.2CREB1
4fetal alcohol syndrome10.6
5attention deficit hyperactivity disorder10.5
6image syndrome10.4
7autism spectrum disorder10.4
8neuronitis10.3
9adult syndrome10.3
10speech disorder10.2
11substance abuse10.2
12wernicke-korsakoff syndrome10.1
13acute neonatal citrullinemia type i10.1
14arts syndrome10.1
15alcohol-related birth defect10.1
16alcohol-related neurodevelopmental disorder10.1
17partial fetal alcohol syndrome10.1
18amblyopia10.1
19sleep disorder10.1
20developmental disabilities10.1
21cleft palate10.1
22burns10.0
23rett syndrome10.0
24cerebritis10.0
25digeorge syndrome10.0
26sudden infant death syndrome10.0
27west syndrome10.0
28microcephaly10.0
29cleft lip10.0
30phenylketonuria10.0
31prader-willi syndrome10.0
32klippel-feil syndrome10.0
33fragile x syndrome10.0
34adrenal carcinoma10.0
35ischemia10.0
36keratoconus10.0
37learning disability10.0
38pyloric stenosis10.0
39retinoschisis10.0
40synostosis10.0
41polymicrogyria10.0
42neuroblastoma10.0BDNF
43medulloblastoma10.0ALDH9A1
44bipolar disorder10.0BDNF, CREB1
45drug addiction10.0BDNF, CREB1
46memory impairment10.0CREB1, BDNF
47mood disorder10.0BDNF, CREB1
48prion disease10.0BDNF, CREB1
49tuberculosis10.0CREB1, SRF
50systemic lupus erythematosus10.0BDNF, CREB1, SRF

Graphical network of the top 20 diseases related to Fetal Alcohol Spectrum Disorder:



Diseases related to fetal alcohol spectrum disorder

Clinical Features for Fetal Alcohol Spectrum Disorder

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Sources:
48Orphanet
See all sources


Symptoms:

48 (show all 31)
  • low set ears/posteriorly rotated ears
  • vertebral segmentation anomaly/hemivertebrae
  • abnormal dermatoglyphics
  • atrial septal defect/interauricular communication
  • visceral angiomatosis (excluding skin)
  • restricted joint mobility/joint stiffness/ankylosis
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • cleft palate without cleft lip/submucosal cleft palate/bifid uvula
  • hirsutism/hypertrichosis/increased body hair
  • diaphragmatic hernia/defect/agenesis
  • stillbirth/neonatal death
  • complete/partial microdontia
  • lateral cleft lip/gingival cleft/paramedian nasal cleft
  • philtrum flat/large/featureless/absent cupidon bows
  • narrow face
  • telecanthus/canthal dystopy
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • psychic/behavioural troubles
  • short stature/dwarfism/nanism
  • intrauterine growth retardation
  • antenatal exposure : alcohol
  • narrow forehead
  • micrognathia/retrognathia/micrognathism/retrognathism
  • anophthalmos/anophthalmia/microphthalmos/microphthalmia
  • strabismus/squint
  • ptosis
  • epicanthic folds
  • short/small nose
  • anteverted nares/nostrils
  • thin/retracted lips
  • microcephaly

Drugs & Therapeutics for Fetal Alcohol Spectrum Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Fetal Alcohol Spectrum Disorder

Drug clinical trials:

Search ClinicalTrials for Fetal Alcohol Spectrum Disorder

Search NIH Clinical Center for Fetal Alcohol Spectrum Disorder

Search CenterWatch for Fetal Alcohol Spectrum Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Fetal Alcohol Spectrum Disorder

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Anatomical Context for Fetal Alcohol Spectrum Disorder

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Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Fetal Alcohol Spectrum Disorder:

32
Eye, Skin, Brain, Testes, Cerebellum, Placenta

Animal Models for Fetal Alcohol Spectrum Disorder or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Fetal Alcohol Spectrum Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.3SRF, CREB1, BDNF, KCNK9
2MP:00053888.0SRF, CREB1, BDNF, KCNK9

Publications for Fetal Alcohol Spectrum Disorder

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Sources:
50PubMed
See all sources

Articles related to Fetal Alcohol Spectrum Disorder:

(show top 50)    (show all 132)
idTitleAuthorsYear
1
Developmental regulation of neuroligin genes in Japanese ricefish (Oryzias latipes) embryogenesis maintains the rhythm during ethanol-induced fetal alcohol spectrum disorder. (24126235)
2014
2
The importance of measurement precision and behavioral homologies in evaluating the behavioral consequences of fetal-ethanol exposure: commentary on williams and colleagues ("sensory-motor deficits in children with fetal alcohol spectrum disorder assessed using a robotic virtual reality platform"). (24299062)
2014
3
Identifying the neurobehavioral phenotype of fetal alcohol spectrum disorder in young children. (24163185)
2013
4
Diffusion tensor imaging correlates of saccadic reaction time in children with fetal alcohol spectrum disorder. (23551175)
2013
5
Evaluating the Psycholegal Abilities of Young Offenders With Fetal Alcohol Spectrum Disorder. (23834387)
2013
6
Potential impacts of the Alberta fetal alcohol spectrum disorder service networks on secondary disabilities: a cost-benefit analysis. (23880478)
2013
7
Fetal alcohol spectrum disorder: can diminished responsibility diminish criminal behaviour? (23228502)
2013
8
Transcendental phenomenology and classic grounded theory as mixed data collection methods in a study exploring fetal alcohol spectrum disorder in New Zealand. (23648310)
2013
9
Cost of specialized addiction treatment of clients with fetal alcohol spectrum disorder in Canada. (23758674)
2013
10
The effectiveness of a community-based intervention program for women at-risk for giving birth to a child with Fetal Alcohol Spectrum Disorder (FASD). (20694802)
2012
11
Ethical considerations when communicating a diagnosis of a fetal alcohol spectrum disorder to a child. (23077138)
2012
12
An exploration of the experiences and perspectives of New Zealanders with fetal alcohol spectrum disorder. (22394603)
2012
13
Aboriginal women, alcohol and the road to fetal alcohol spectrum disorder. (22762220)
2012
14
Children with fetal alcohol spectrum disorder show an amblyopia-like pattern of vision deficit. (22574626)
2012
15
Sleep and sensory characteristics in young children with fetal alcohol spectrum disorder. (21654404)
2011
16
Mental health issues in fetal alcohol spectrum disorder. (21780939)
2011
17
Changes in health professionals' knowledge, attitudes and practice following provision of educational resources about prevention of prenatal alcohol exposure and fetal alcohol spectrum disorder. (21649674)
2011
18
Paediatricians' knowledge, attitudes and practice following provision of educational resources about prevention of prenatal alcohol exposure and Fetal Alcohol Spectrum Disorder. (21449899)
2011
19
Ethical, legal and policy issues in management of fetal alcohol spectrum disorder. (23252025)
2011
20
Developmental delay of infants and young children with and without fetal alcohol spectrum disorder in the Northern Cape Province, South Africa. (22038428)
2011
21
Executive function and memory in children with Fetal Alcohol Spectrum Disorder. (21718218)
2011
22
Fetal alcohol spectrum disorder prevalence estimates in correctional systems: a systematic literature review. (22032097)
2011
23
Differentiating attention deficits in children with fetal alcohol spectrum disorder or attention-deficit-hyperactivity disorder. (19549201)
2010
24
Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disorders. (20164336)
2010
25
Profile of the first 1,400 patients receiving diagnostic evaluations for fetal alcohol spectrum disorder at the Washington State Fetal Alcohol Syndrome Diagnostic & Prevention Network. (20335648)
2010
26
Communicating the risks of fetal alcohol spectrum disorder: effects of message framing and exemplification. (21153985)
2010
27
Results of a nurse-led workshop designed to prevent fetal alcohol spectrum disorder. (20525095)
2010
28
Fetal alcohol syndrome and fetal alcohol spectrum disorder in Indigenous schoolchildren. (19296803)
2009
29
Potential role of the placenta in fetal alcohol spectrum disorder. (19127948)
2009
30
Were our forebears aware of prenatal alcohol exposure and its effects? A review of the history of fetal alcohol spectrum disorder. (19439773)
2009
31
Modulation of GABAergic and glutamatergic transmission by ethanol in the developing neocortex: an in vitro test of the excessive inhibition hypothesis of fetal alcohol spectrum disorder. (19027758)
2009
32
Problems expressed by caregivers of children with fetal alcohol spectrum disorder. (19883455)
2009
33
Fetal alcohol spectrum disorder in Israel. (20077950)
2009
34
Modulation of glutamatergic transmission by sulfated steroids: role in fetal alcohol spectrum disorder. (17597219)
2008
35
Knowledge and attitudes of criminal justice professionals in relation to Fetal Alcohol Spectrum Disorder. (18678920)
2008
36
Disruption of circulation by ethanol promotes fetal alcohol spectrum disorder (FASD) in medaka (Oryzias latipes) embryogenesis. (18621148)
2008
37
Fetal alcohol spectrum disorder. (19129565)
2008
38
Fetal alcohol spectrum disorder prevention approaches among Canadian physicians by proportion of Native/Aboriginal patients: practices during the preconception and prenatal periods. (17243020)
2007
39
Knowledge and attitudes about fetal alcohol syndrome, fetal alcohol spectrum disorders, and alcohol use during pregnancy by occupational therapists in the Midwest. (19759993)
2007
40
Rural FASD diagnostic services model: Lakeland Centre for fetal alcohol spectrum disorder. (18025547)
2007
41
Hearing in children with fetal alcohol spectrum disorder (FASD). (18025546)
2007
42
National Institute on Alcohol Abuse and Alcoholism and the study of fetal alcohol spectrum disorders. The International Consortium. (16801719)
2006
43
Evidence-based review of nursing interventions to prevent secondary disabilities in fetal alcohol spectrum disorder. (16719426)
2006
44
Alcohol is a potent stimulant of immature neuronal networks: implications for fetal alcohol spectrum disorder. (16000153)
2005
45
Screening for fetal alcohol spectrum disorder. (15732218)
2005
46
Identifying fetal alcohol spectrum disorder in primary care. (15738484)
2005
47
Fetal alcohol spectrum disorder. (15898848)
2005
48
Fetal alcohol spectrum disorder. (14665662)
2003
49
Fetal alcohol spectrum disorder and ADHD: diagnostic implications and therapeutic consequences. (19810932)
2003
50
Fetal alcohol spectrum disorder - New diagnostic initiatives. (20046284)
2002

Genetic Variations for Fetal Alcohol Spectrum Disorder

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Expression for genes affiliated with Fetal Alcohol Spectrum Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Fetal Alcohol Spectrum Disorder

Search GEO for disease gene expression data for Fetal Alcohol Spectrum Disorder.

Pathways for genes affiliated with Fetal Alcohol Spectrum Disorder

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Fetal Alcohol Spectrum Disorder

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
13-nitropropionic acid449.9CREB1, BDNF
2antidepressants499.9CREB1, BDNF
3quisqualate44 1110.9CREB1, BDNF
4dopac449.9BDNF, ALDH9A1
5bisindolylmaleimide449.8CREB1, BDNF
6risperidone28 44 49 59 11 2414.8CREB1, BDNF
7desipramine44 49 1111.8CREB1, BDNF
8methamphetamine44 49 1111.8CREB1, BDNF
9fluoxetine49 44 28 1112.8BDNF, CREB1
10citalopram49 44 11 2412.8BDNF, CREB1
11betaine aldehyde44 2410.8ADH6, ALDH9A1
12valproate449.8BDNF, CREB1
136-hydroxydopamine449.7CREB1, BDNF
14imipramine44 49 28 11 2413.6CREB1, BDNF
15acetaldehyde44 28 2411.6ADH6, ALDH9A1
16pilocarpine44 28 1111.5BDNF, SRF
17daidzein449.5ALDH9A1, SRF
18lithium44 49 11 2412.5CREB1, BDNF
19melatonin44 59 28 11 2413.5BDNF, CREB1
20levodopa44 1110.4ALDH9A1, CREB1, BDNF
21gaba449.4BDNF, CREB1, ALDH9A1
22n acetylcysteine449.4ALDH9A1, CREB1, BDNF
23spermine44 28 11 2412.3ALDH9A1, SRF
24choline44 11 2411.2BDNF, ALDH9A1, ADH6
25ethanol44 49 11 2412.2BDNF, ALDH9A1, ADH6
26dopamine44 28 11 2412.2BDNF, CREB1, ALDH9A1
27k252a449.1BDNF, CREB1, SRF
28dbc-amp449.1BDNF, CREB1, SRF
294-hydroxynonenal44 2410.1ALDH9A1, CREB1, SRF
30agar449.1SRF, CREB1, BDNF
31retinoid449.1ALDH9A1, CREB1, SRF
32nmda44 2810.0CREB1, SRF, BDNF
33adenylate449.0CREB1, BDNF, ALDH9A1
34histamine44 28 2411.0SRF, BDNF, CREB1
35acetylcholine44 49 28 11 2413.0SRF, BDNF, CREB1
36estradiol44 11 2411.0CREB1, BDNF, SRF
37forskolin44 49 1111.0BDNF, CREB1, SRF
38genistein44 28 59 2 11 2414.0ALDH9A1, CREB1, SRF
39lysine448.9SRF, KCNK9, BDNF
40norepinephrine44 11 2410.6CREB1, SRF, ALDH9A1, BDNF
41lactate448.6BDNF, CREB1, SRF, ALDH9A1
42cyclic amp44 249.6BDNF, CREB1, SRF
43testosterone44 59 11 2411.6SRF, CREB1, BDNF, ALDH9A1
44retinoic acid44 249.5ALDH9A1, BDNF, SRF, CREB1
45vitamin a44 11 2410.5CREB1, SRF, ALDH9A1, ADH6
46zinc44 249.5ADH6, SRF, CREB1, BDNF
47lipid448.5SRF, BDNF, CREB1, ALDH9A1
48nadph44 249.4ALDH9A1, ADH6, SRF, BDNF
49glutamate448.2CREB1, KCNK9, BDNF, SRF, ALDH9A1
50serine447.9BDNF, SRF, CREB1, ALDH9A1

GO Terms for genes affiliated with Fetal Alcohol Spectrum Disorder

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Sources:
16Gene Ontology
See all sources

Cellular components related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:0080219.5BDNF, KCNK9

Biological processes related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hormone stimulusGO:0097259.1SRF, BDNF

Molecular functions related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:0037059.2SRF, CREB1

Products for genes affiliated with Fetal Alcohol Spectrum Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fetal Alcohol Spectrum Disorder

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet