MCID: FTL006
MIFTS: 48

Fetal Alcohol Spectrum Disorder

Categories: Rare diseases, Fetal diseases, Neuronal diseases, Mental diseases

Aliases & Classifications for Fetal Alcohol Spectrum Disorder

MalaCards integrated aliases for Fetal Alcohol Spectrum Disorder:

Name: Fetal Alcohol Spectrum Disorder 12 3 14
Fetal Alcohol Spectrum Disorders 49 40 69
Alcohol-Related Neurodevelopmental Disorder - Type 49
Alcohol-Related Birth Defects - Type 49
Fetal Alcohol Syndrome - Type 49
Fetal Alcohol Syndrome 69
Fasd 49

Classifications:



External Ids:

Disease Ontology 12 DOID:0050696

Summaries for Fetal Alcohol Spectrum Disorder

MedlinePlus : 40 Alcohol can harm your baby at any stage during a pregnancy. That includes the earliest stages, before you even know you are pregnant. Drinking during pregnancy can cause a group of conditions called fetal alcohol spectrum disorders (FASDs). Children who are born with FASD can have a mix of problems, such as medical, behavioral, educational, and social problems. The kinds of problems they have depend on which type of FASD they have. The problems could include Abnormal facial features, such as a smooth ridge between the nose and upper lip Small head size Shorter-than-average height Low body weight Poor coordination Hyperactive behavior Difficulty with attention and memory Learning disabilities and difficulty in school Speech and language delays Intellectual disability or low IQ Poor reasoning and judgment skills Sleep and sucking problems as a baby Vision or hearing problems Problems with the heart, kidneys, or bones Fetal alcohol syndrome (FAS) is the most serious type of FASD. People with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. Diagnosing FASD can be hard because there is no medical test for it. The health care provider will make a diagnosis by looking at the child's signs and symptoms, and will ask whether the mother drank alcohol during pregnancy. FASDs last a lifetime. There is no cure for FASDs, but treatments can help. These include medicines to help with some symptoms, medical care for health problems, behavior and education therapy, and parent training. A good treatment plan is specific to the child's problems. It should include close monitoring, follow-ups, and changes when needed. Certain "protective factors" can help reduce the effects of FASDs and help people who have them reach their full potential. They include Diagnosis before 6 years of age Loving, nurturing, and stable home environment during the school years Absence of violence around them Involvement in special education and social services There is no known safe amount of alcohol during pregnancy. To prevent FASDs, you should not drink alcohol while you are pregnant, or when you might get pregnant. Centers for Disease Control and Prevention

MalaCards based summary : Fetal Alcohol Spectrum Disorder, also known as fetal alcohol spectrum disorders, is related to fetal alcohol syndrome and ocular dominance. An important gene associated with Fetal Alcohol Spectrum Disorder is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are Ras signaling pathway and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. The drugs Ethanol and Epigallocatechin gallate have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and kidney, and related phenotypes are Decreased caspase 3/7 activity and Decreased shRNA abundance

Disease Ontology : 12 A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.

CDC : 3 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose mother drank alcohol during pregnancy. FASDs are completely preventable if a woman does not drink alcohol during pregnancy.

Wikipedia : 72 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose... more...

Related Diseases for Fetal Alcohol Spectrum Disorder

Diseases in the Fetal Alcohol Syndrome family:

Fetal Alcohol Spectrum Disorder

Diseases related to Fetal Alcohol Spectrum Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 fetal alcohol syndrome 32.1 ADH7 GRIN2A GRIN2B MIR496 PFAS RBP1
2 ocular dominance 29.8 BDNF GRIN2A GRIN2B
3 autism spectrum disorder 29.5 ADNP BDNF GRIN2A GRIN2B
4 partial fetal alcohol syndrome 11.0
5 alcohol-related neurodevelopmental disorder 11.0
6 alcohol-related birth defect 11.0
7 attention deficit-hyperactivity disorder 10.2
8 autism 10.1
9 aging 10.1
10 neuronitis 10.0
11 valproate embryopathy 9.9 BDNF GRIN2A GRIN2B SHH
12 down syndrome 9.8
13 alcohol abuse 9.8
14 amblyopia 9.8
15 cornelia de lange syndrome 9.8
16 cerebritis 9.8
17 disease of mental health 9.8 BDNF GRIN2A GRIN2B
18 status epilepticus 9.5 BDNF CASP3 GRIN2B
19 toxic encephalopathy 9.5 BDNF CASP3 GRIN2A GRIN2B
20 alcohol dependence 9.5 ADH6 ADH7 ALDH9A1 BDNF GRIN2A GRIN2B
21 huntington disease 9.4 BDNF CASP3 GRIN2A GRIN2B

Graphical network of the top 20 diseases related to Fetal Alcohol Spectrum Disorder:



Diseases related to Fetal Alcohol Spectrum Disorder

Symptoms & Phenotypes for Fetal Alcohol Spectrum Disorder

GenomeRNAi Phenotypes related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased caspase 3/7 activity GR00318-A 9.13 CASP3 GRIN2A GRIN2B
2 Decreased shRNA abundance GR00251-A-1 9.1 ALDH9A1
3 Decreased shRNA abundance GR00251-A-2 9.1 ALDH9A1
4 Decreased shRNA abundance GR00297-A 9.1 ADH6 ALDH9A1 DIO3 SV2C

MGI Mouse Phenotypes related to Fetal Alcohol Spectrum Disorder:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.96 ADH7 ASPH BDNF CASP3 DIO3 GRIN2B
2 craniofacial MP:0005382 9.8 CASP3 IGF2 PFAS SHH ASPH BDNF
3 integument MP:0010771 9.7 ALDH9A1 BDNF CASP3 GRIN2A IGF2 PFAS
4 nervous system MP:0003631 9.61 ADH7 ADNP BDNF CASP3 GRIN2A GRIN2B
5 taste/olfaction MP:0005394 8.92 ADH7 BDNF CASP3 SHH

Drugs & Therapeutics for Fetal Alcohol Spectrum Disorder

Drugs for Fetal Alcohol Spectrum Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 2, Phase 3, Phase 1, Early Phase 1 64-17-5 702
2
Epigallocatechin gallate Investigational Phase 2, Phase 3 989-51-5 65064
3 Anti-Infective Agents Phase 2, Phase 3,Phase 1,Early Phase 1
4 Anti-Infective Agents, Local Phase 2, Phase 3,Phase 1,Early Phase 1
5 Antioxidants Phase 2, Phase 3
6 Central Nervous System Depressants Phase 2, Phase 3,Phase 1,Early Phase 1
7 Neuroprotective Agents Phase 2, Phase 3
8 Protective Agents Phase 2, Phase 3
9 Adrenergic Agents Phase 3,Phase 1
10 Atomoxetine Hydrochloride Phase 3,Phase 1
11 Neurotransmitter Agents Phase 3,Phase 1
12 Neurotransmitter Uptake Inhibitors Phase 3,Phase 1
13
Epigallocatechin Experimental, Investigational, Nutraceutical Phase 2, Phase 3 970-74-1 72277
14
Choline Approved, Nutraceutical Phase 2,Phase 1 62-49-7 305
15 Antimetabolites Phase 2,Phase 1
16 Gastrointestinal Agents Phase 2,Phase 1
17 Hypolipidemic Agents Phase 2,Phase 1
18 Lipid Regulating Agents Phase 2,Phase 1
19 Nootropic Agents Phase 2,Phase 1
20
Nicotine Approved 54-11-5 89594 942
21
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
22 tannic acid Approved, Nutraceutical

Interventional clinical trials:

(show all 33)

# Name Status NCT ID Phase Drugs
1 Epigallocatechin Gallate (EGCG) to Improve Cognitive Performance in Foetal Alcohol Syndrome (FAS) Children Unknown status NCT02558933 Phase 2, Phase 3
2 Open-Label Study of the Long Term Tolerability and Safety of Atomoxetine in Children With FASD and ADD/ADHD Completed NCT00418262 Phase 3 Atomoxetine
3 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
4 Fetal Alcohol Syndrome/ARND Research Consortion Completed NCT00164554 Phase 1, Phase 2
5 Fetal Alcohol Syndrome: Socio-Cognitive Habilitation Completed NCT00164229 Phase 1, Phase 2
6 Neurocognitive Habilitation for Children With Fetal Alcohol Syndrome (FAS)/Alcohol-Related Neurodevelopmental Disorder (ARND) Completed NCT00164346 Phase 1, Phase 2
7 A Media Based Motivational Intervention to Prevent Alcohol Exposed Pregnancies (AEPs) Completed NCT00219336 Phase 2
8 Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Completed NCT01149538 Phase 1, Phase 2 Choline bitartrate
9 Project CHOICES Efficacy Study Completed NCT00153478 Phase 2
10 Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Recruiting NCT02735473 Phase 2 Choline bitartrate;Placebo
11 Neighborhood Alcohol & HIV Prevention in South African Townships (Philani) Active, not recruiting NCT00996528 Phase 2
12 Assess the Effectiveness of Atomoxetine in Children With Fetal Alcohol Syndrome and ADD/ADHD Completed NCT00417794 Phase 1 Strattera;Placebo
13 Parenting Training for Children With FASD Unknown status NCT02210455
14 Evaluating the Effectiveness of an Attachment-Focused Intervention in Preschool Children With FASD Completed NCT01536184
15 Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention Completed NCT02457676
16 Contraception and Alcohol Risk Reduction Internet Intervention Randomized Trial Completed NCT02128880
17 Development of Education Materials for Prevention of FAS in Russia Completed NCT01971398
18 Preventing FAS/ARND in Russian Children Completed NCT01961050
19 Fetal Alcohol Damage Prevention Study Completed NCT00696085
20 Expansion to Interdisciplinary HIV Prevention in Women Completed NCT01994603
21 Healthy Moms Alcohol Intervention Completed NCT00244062
22 Comprehensive Program for Youth Mental Health Completed NCT02169960
23 Modeling and Testing Change in Mental Abilities in Childhood Completed NCT02459873
24 Effects of Hyperbaric Oxygen Therapy in Autistic Children: A Pilot Study Completed NCT00324909 Hyperbaric Oxygen Therapy
25 Reducing Alcohol Exposed Pregnancy Risk: EARLY Randomized Controlled Trial Completed NCT01446653
26 Cognitive Training and tDCS for Children With FASD Recruiting NCT03361293
27 Self-Regulation in Adolescents With FASD: The Efficacy of a Targeted Intervention Recruiting NCT02912962
28 In Utero Alcoholic Exposure: PlGF, Biomarker of Fetal Brain Lesions Recruiting NCT03371641
29 Prenatal Alcohol Biomarker Study in Uruguay Recruiting NCT02600624
30 Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial Recruiting NCT03342495
31 Prevention of Fetal Alcohol Spectrum Disorder (FASD) by the Use of Technology Enrolling by invitation NCT02759874
32 Better Nights, Better Days for Children With Neurodevelopment Disorders Not yet recruiting NCT02694003
33 Evaluating the Efficacy of a Video Based Intervention to Educate Teen Moms About Fetal Alcohol Syndrome (FAS) Terminated NCT00747630 Early Phase 1

Search NIH Clinical Center for Fetal Alcohol Spectrum Disorder

Genetic Tests for Fetal Alcohol Spectrum Disorder

Anatomical Context for Fetal Alcohol Spectrum Disorder

MalaCards organs/tissues related to Fetal Alcohol Spectrum Disorder:

38
Testes, Eye, Kidney, Heart, Bone, Brain, Fetal Brain

Publications for Fetal Alcohol Spectrum Disorder

Articles related to Fetal Alcohol Spectrum Disorder:

(show top 50) (show all 235)
# Title Authors Year
1
Ethical aspects of diagnosis and interventions for children with fetal alcohol Spectrum disorder (FASD) and their families. ( 29304784 )
2018
2
DNA methylation as a predictor of fetal alcohol spectrum disorder. ( 29344313 )
2018
3
Deferred diagnosis in children assessed for fetal alcohol spectrum disorder. ( 29432031 )
2018
4
Fetal alcohol spectrum disorder and youth justice: a prevalence study among young people sentenced to detention in Western Australia. ( 29440216 )
2018
5
Utility of Genetic Testing in Fetal Alcohol Spectrum Disorder. ( 29398060 )
2018
6
Educational Opportunities for Fetal Alcohol Spectrum Disorder Prevention. ( 28582350 )
2017
7
A Critique of the New Canadian Fetal Alcohol Spectrum Disorder Guideline. ( 29056979 )
2017
8
Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review. ( 28645298 )
2017
9
Acute oligodendrocyte loss with persistent white matter injury in a third trimester equivalent mouse model of fetal alcohol spectrum disorder. ( 28518477 )
2017
10
Fine motor skills in a population of children in remote Australia with high levels of prenatal alcohol exposure and Fetal Alcohol Spectrum Disorder. ( 29157212 )
2017
11
Suicide and suicide attempts among women in the Manitoba Mothers and Fetal Alcohol Spectrum Disorder cohort: a retrospective matched analysis using linked administrative data. ( 28830865 )
2017
12
Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder. ( 28723918 )
2017
13
Metabolomics and fetal alcohol spectrum disorder: A Mini-Review. ( 28686845 )
2017
14
Oral narrative of individuals with Fetal Alcohol Spectrum Disorder. ( 28813074 )
2017
15
Preliminary Findings that a Targeted Intervention Leads to Altered Brain Function in Children with Fetal Alcohol Spectrum Disorder. ( 29283403 )
2017
16
The Psychiatric Morbidity of Women Who Give Birth to Children with Fetal Alcohol Spectrum Disorder (FASD): Results of the Manitoba Mothers and FASD Study. ( 28548001 )
2017
17
Fetal Alcohol Spectrum Disorder Diagnosis: Current Practices and Future Considerations. ( 28746809 )
2017
18
Turmeric Extract Rescues Ethanol-Induced Developmental Defect in the Zebrafish Model for Fetal Alcohol Spectrum Disorder (FASD). ( 28796310 )
2017
19
Human Brain Abnormalities Associated With Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder. ( 28859338 )
2017
20
Advances in developmental neuropsychiatry: autism spectrum disorder, Cornelia De Lange syndrome, self-injurious behavior, Down syndrome, fetal alcohol spectrum disorder, and borderline intellectual functioning. ( 28067728 )
2017
21
Global Prevalence of Alcohol Use and Binge Drinking During Pregnancy and Fetal Alcohol Spectrum Disorder. ( 28834683 )
2017
22
Skeletal muscle and fetal alcohol spectrum disorder. ( 29091741 )
2017
23
What the Spectrum of Microglial Functions Can Teach us About Fetal Alcohol Spectrum Disorder. ( 28674490 )
2017
24
Prevalence of Externalizing Disorders and Autism Spectrum Disorder among Children with Fetal Alcohol Spectrum Disorder: Systematic Review and Meta-analysis. ( 28521112 )
2017
25
Fetal Alcohol Spectrum Disorder-High Rates, High Needs, High Time for Action. ( 28828475 )
2017
26
New Opportunities for Evidence in Fetal Alcohol Spectrum Disorder. ( 28586845 )
2017
27
Age-Related Differences in Neuropsychological Assessment of Fetal Alcohol Spectrum Disorder: A Cross-sectional Study. ( 28796950 )
2017
28
Global Prevalence of Fetal Alcohol Spectrum Disorder Among Children and Youth: A Systematic Review and Meta-analysis. ( 28828483 )
2017
29
The Marulu Strategy 2008-2012: overcoming Fetal Alcohol Spectrum Disorder (FASD) in the Fitzroy Valley. ( 28749590 )
2017
30
Fetal Alcohol Syndrome and Fetal Alcohol Spectrum Disorders. ( 29094891 )
2017
31
Altered neural oscillations during multisensory integration in adolescents with fetal alcohol spectrum disorder. ( 28944474 )
2017
32
Visual-motor integration, visual perception, and fine motor coordination in a population of children with high levels of Fetal Alcohol Spectrum Disorder. ( 27228005 )
2016
33
Productivity losses associated with Fetal Alcohol Spectrum Disorder in New Zealand. ( 27538041 )
2016
34
Social perception in children with fetal alcohol spectrum disorder. ( 27829119 )
2016
35
Fetal alcohol spectrum disorder: reconsidering blame. ( 26811363 )
2016
36
Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis. ( 26777270 )
2016
37
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. ( 26608087 )
2016
38
Graphomotor skills in children with prenatal alcohol exposure and fetal alcohol spectrum disorder: A population-based study in remote Australia. ( 27646500 )
2016
39
Prevention of Fetal Alcohol Spectrum Disorder: Current Canadian Efforts and Analysis of Gaps. ( 27199560 )
2016
40
Immediate Neural Plasticity Involving Reaction Time in a Saccadic Eye Movement Task is Intact in Children With Fetal Alcohol Spectrum Disorder. ( 27716964 )
2016
41
DNA methylation signature of human fetal alcohol spectrum disorder. ( 27358653 )
2016
42
Fetal alcohol spectrum disorder: a guideline for diagnosis across the lifespan. ( 26668194 )
2016
43
Caregiver needs and stress in caring for individuals with fetal alcohol spectrum disorder. ( 27058320 )
2016
44
Usability Testing of Guided Internet-based Parent Training for Challenging Behavior in Children with Fetal Alcohol Spectrum Disorder (Strongest Families FASD). ( 27115205 )
2016
45
Fetal alcohol spectrum disorder: complexity from comorbidity. ( 26777271 )
2016
46
Adults with Fetal Alcohol Spectrum Disorder: Factors Associated with Positive Outcomes and Contact with the Criminal Justice System. ( 26962847 )
2016
47
Dysregulation of TrkB phosphorylation and proBDNF protein in adenylyl cyclase 1 and 8 knockout mice in a model of fetal alcohol spectrum disorder. ( 26992697 )
2016
48
1 in 100 babies: the fetal alcohol spectrum disorder pathway. ( 27892236 )
2016
49
Developmental and behavioral consequences of early life maternal separation stress in a mouse model of fetal alcohol spectrum disorder. ( 27102339 )
2016
50
Special Education of Children with Fetal Alcohol Spectrum Disorder. ( 27695197 )
2016

Variations for Fetal Alcohol Spectrum Disorder

Expression for Fetal Alcohol Spectrum Disorder

Search GEO for disease gene expression data for Fetal Alcohol Spectrum Disorder.

Pathways for Fetal Alcohol Spectrum Disorder

GO Terms for Fetal Alcohol Spectrum Disorder

Cellular components related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NMDA selective glutamate receptor complex GO:0017146 8.62 GRIN2A GRIN2B

Biological processes related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.8 ADH6 ADH7 ALDH9A1 ASPH DIO3
2 ionotropic glutamate receptor signaling pathway GO:0035235 9.43 GRIN2A GRIN2B
3 retinoic acid metabolic process GO:0042573 9.37 ADH7 RBP1
4 glutamate receptor signaling pathway GO:0007215 9.32 GRIN2A GRIN2B
5 ethanol oxidation GO:0006069 9.26 ADH6 ADH7
6 calcium ion transmembrane import into cytosol GO:0097553 9.16 GRIN2A GRIN2B
7 learning or memory GO:0007611 9.13 CASP3 GRIN2A GRIN2B
8 response to ethanol GO:0045471 8.92 ADH6 ADH7 GRIN2A GRIN2B

Molecular functions related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.85 ADH6 ADH7 GRIN2A GRIN2B SHH
2 oxidoreductase activity GO:0016491 9.72 ADH6 ADH7 ALDH9A1 ASPH DIO3
3 extracellularly glutamate-gated ion channel activity GO:0005234 9.43 GRIN2A GRIN2B
4 ionotropic glutamate receptor activity GO:0004970 9.4 GRIN2A GRIN2B
5 retinol binding GO:0019841 9.37 ADH7 RBP1
6 alcohol dehydrogenase (NAD) activity GO:0004022 9.26 ADH6 ADH7
7 NMDA glutamate receptor activity GO:0004972 9.16 GRIN2A GRIN2B
8 alcohol dehydrogenase activity, zinc-dependent GO:0004024 8.96 ADH6 ADH7
9 glutamate-gated calcium ion channel activity GO:0022849 8.62 GRIN2A GRIN2B

Sources for Fetal Alcohol Spectrum Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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