FASD
MCID: FTL006
MIFTS: 43

Fetal Alcohol Spectrum Disorder (FASD) malady

Categories: Rare diseases, Mental diseases, Neuronal diseases, Fetal diseases

Aliases & Classifications for Fetal Alcohol Spectrum Disorder

Aliases & Descriptions for Fetal Alcohol Spectrum Disorder:

Name: Fetal Alcohol Spectrum Disorder 12 3 14
Fetal Alcohol Spectrum Disorders 50 41 69
Alcohol-Related Neurodevelopmental Disorder - Type 50
Alcohol-Related Birth Defects - Type 50
Fetal Alcohol Syndrome - Type 50
Fetal Alcohol Syndrome 69
Fasd 50

Classifications:



External Ids:

Disease Ontology 12 DOID:0050696

Summaries for Fetal Alcohol Spectrum Disorder

MedlinePlus : 41 alcohol can harm your baby at any stage during a pregnancy. that includes the earliest stages before you even know you are pregnant. drinking alcohol can cause a group of conditions called fetal alcohol spectrum disorders (fasds). effects can include physical and behavioral problems such as trouble with learning and remembering understanding and following directions controlling emotions communicating and socializing daily life skills, such as feeding and bathing fetal alcohol syndrome is the most serious type of fasd. people with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. fasds last a lifetime. there is no cure for fasds. treatments can help. these include medicines to help with some symptoms and behavior therapy. no one treatment is right for every child. centers for disease control and prevention

MalaCards based summary : Fetal Alcohol Spectrum Disorder, also known as fetal alcohol spectrum disorders, is related to alcohol-related birth defect and fetal alcohol syndrome. An important gene associated with Fetal Alcohol Spectrum Disorder is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are Glucose metabolism and superpathway of tryptophan utilization. The drugs Ethanol and Adrenergic Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related phenotypes are Decreased shRNA abundance and growth/size/body region

Disease Ontology : 12 A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.

CDC : 3 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose mother drank alcohol during pregnancy. FASDs are completely preventable if a woman does not drink alcohol during pregnancy.

Wikipedia : 71 Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose... more...

Related Diseases for Fetal Alcohol Spectrum Disorder

Graphical network of the top 20 diseases related to Fetal Alcohol Spectrum Disorder:



Diseases related to Fetal Alcohol Spectrum Disorder

Symptoms & Phenotypes for Fetal Alcohol Spectrum Disorder

GenomeRNAi Phenotypes related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00251-A-1 9.17 ALDH9A1
2 Decreased shRNA abundance GR00251-A-2 9.17 ALDH9A1
3 Decreased shRNA abundance GR00297-A 9.17 ADH6 AKR1A1 ALDH9A1 DIO3 SV2C

MGI Mouse Phenotypes related to Fetal Alcohol Spectrum Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.96 ADH7 AKR1A1 BDNF DIO3 GRIN2B IGF2
2 nervous system MP:0003631 9.81 SHH SOX3 ADH7 ADNP BDNF GRIN2A
3 craniofacial MP:0005382 9.8 AKR1A1 BDNF IGF2 PFAS SHH SOX3
4 reproductive system MP:0005389 9.5 AKR1A1 BDNF DIO3 IGF2 RBP1 SHH
5 taste/olfaction MP:0005394 8.8 ADH7 BDNF SHH

Drugs & Therapeutics for Fetal Alcohol Spectrum Disorder

Drugs for Fetal Alcohol Spectrum Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 3,Phase 2,Phase 1,Early Phase 1 64-17-5 702
2 Adrenergic Agents Phase 3,Phase 1
3 Atomoxetine Hydrochloride Phase 3,Phase 1
4 Neurotransmitter Agents Phase 3,Phase 1
5 Neurotransmitter Uptake Inhibitors Phase 3,Phase 1
6 Anti-Infective Agents Phase 2, Phase 3,Phase 1,Early Phase 1
7 Anti-Infective Agents, Local Phase 2, Phase 3,Phase 1,Early Phase 1
8 Central Nervous System Depressants Phase 2, Phase 3,Phase 1,Early Phase 1
9 Antioxidants Phase 2, Phase 3
10
Epigallocatechin gallate Phase 2, Phase 3 989-51-5 65064
11 Neuroprotective Agents Phase 2, Phase 3
12 Protective Agents Phase 2, Phase 3
13
Epigallocatechin Experimental, Nutraceutical Phase 2, Phase 3 970-74-1 72277
14
Glycerol Approved, Experimental Phase 2 56-81-5 753
15
Choline Approved, Nutraceutical Phase 2,Phase 1 62-49-7 305
16 Antimetabolites Phase 2,Phase 1
17 Gastrointestinal Agents Phase 2,Phase 1
18 Hypolipidemic Agents Phase 2,Phase 1
19 Lipid Regulating Agents Phase 2,Phase 1
20 Nootropic Agents Phase 2,Phase 1
21
Nicotine Approved 54-11-5 942 89594
22
Benzocaine Approved 1994-09-7, 94-09-7 2337
23 tannic acid Approved, Nutraceutical

Interventional clinical trials:

(show all 30)
id Name Status NCT ID Phase
1 Open-Label Study of the Long Term Tolerability and Safety of Atomoxetine in Children With FASD and ADD/ADHD Unknown status NCT00418262 Phase 3
2 Epigallocatechin Gallate (EGCG) to Improve Cognitive Performance in Foetal Alcohol Syndrome (FAS) Children Recruiting NCT02558933 Phase 2, Phase 3
3 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
4 Fetal Alcohol Syndrome/ARND Research Consortion Completed NCT00164554 Phase 1, Phase 2
5 Fetal Alcohol Syndrome: Socio-Cognitive Habilitation Completed NCT00164229 Phase 1, Phase 2
6 Neurocognitive Habilitation for Children With Fetal Alcohol Syndrome (FAS)/Alcohol-Related Neurodevelopmental Disorder (ARND) Completed NCT00164346 Phase 1, Phase 2
7 A Media Based Motivational Intervention to Prevent Alcohol Exposed Pregnancies (AEPs) Completed NCT00219336 Phase 2
8 Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Completed NCT01149538 Phase 1, Phase 2
9 Project CHOICES Efficacy Study Completed NCT00153478 Phase 2
10 Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Recruiting NCT02735473 Phase 2
11 Neighborhood Alcohol & HIV Prevention in South African Townships (Philani) Active, not recruiting NCT00996528 Phase 2
12 Assess the Effectiveness of Atomoxetine in Children With Fetal Alcohol Syndrome and ADD/ADHD Completed NCT00417794 Phase 1
13 Evaluating the Effectiveness of an Attachment-Focused Intervention in Preschool Children With FASD Completed NCT01536184
14 Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention Completed NCT02457676
15 Contraception and Alcohol Risk Reduction Internet Intervention Randomized Trial Completed NCT02128880
16 Development of Education Materials for Prevention of FAS in Russia Completed NCT01971398
17 Preventing FAS/ARND in Russian Children Completed NCT01961050
18 Fetal Alcohol Damage Prevention Study Completed NCT00696085
19 Healthy Moms Alcohol Intervention Completed NCT00244062
20 Expansion to Interdisciplinary HIV Prevention in Women Completed NCT01994603
21 Comprehensive Program for Youth Mental Health Completed NCT02169960
22 Modeling and Testing Change in Mental Abilities in Childhood Completed NCT02459873
23 Effects of Hyperbaric Oxygen Therapy in Autistic Children: A Pilot Study Completed NCT00324909
24 Reducing Alcohol Exposed Pregnancy Risk: EARLY Randomized Controlled Trial Completed NCT01446653
25 Parenting Training for Children With FASD Recruiting NCT02210455
26 Prenatal Alcohol Biomarker Study in Uruguay Recruiting NCT02600624
27 Prevention of Fetal Alcohol Spectrum Disorder (FASD) by the Use of Technology Enrolling by invitation NCT02759874
28 Self-Regulation in Adolescents With FASD: The Efficacy of a Targeted Intervention Not yet recruiting NCT02912962
29 Better Nights, Better Days for Children With Neurodevelopment Disorders Not yet recruiting NCT02694003
30 Evaluating the Efficacy of a Video Based Intervention to Educate Teen Moms About Fetal Alcohol Syndrome (FAS) Terminated NCT00747630 Early Phase 1

Search NIH Clinical Center for Fetal Alcohol Spectrum Disorder

Genetic Tests for Fetal Alcohol Spectrum Disorder

Anatomical Context for Fetal Alcohol Spectrum Disorder

MalaCards organs/tissues related to Fetal Alcohol Spectrum Disorder:

39
Eye, Testes, Brain, Placenta, Cortex, Cerebellum

Publications for Fetal Alcohol Spectrum Disorder

Articles related to Fetal Alcohol Spectrum Disorder:

(show top 50) (show all 205)
id Title Authors Year
1
Advances in developmental neuropsychiatry: autism spectrum disorder, Cornelia De Lange syndrome, self-injurious behavior, Down syndrome, fetal alcohol spectrum disorder, and borderline intellectual functioning. ( 28067728 )
2017
2
DNA methylation signature of human fetal alcohol spectrum disorder. ( 27358653 )
2016
3
Fetal alcohol spectrum disorder: complexity from comorbidity. ( 26777271 )
2016
4
Parent rating of executive function in fetal alcohol spectrum disorder: A review of the literature and new data on Aboriginal Canadian children. ( 27282764 )
2016
5
Caregiver needs and stress in caring for individuals with fetal alcohol spectrum disorder. ( 27058320 )
2016
6
Fetal alcohol spectrum disorder: a guideline for diagnosis across the lifespan. ( 26668194 )
2016
7
Factors predictive of a fetal alcohol spectrum disorder: Neuropsychological assessment. ( 27830992 )
2016
8
Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis. ( 26777270 )
2016
9
Productivity losses associated with Fetal Alcohol Spectrum Disorder in New Zealand. ( 27538041 )
2016
10
Visual-motor integration, visual perception, and fine motor coordination in a population of children with high levels of Fetal Alcohol Spectrum Disorder. ( 27228005 )
2016
11
Usability Testing of Guided Internet-based Parent Training for Challenging Behavior in Children with Fetal Alcohol Spectrum Disorder (Strongest Families FASD). ( 27115205 )
2016
12
Guidelines for identification and treatment of individuals with attention deficit/hyperactivity disorder and associated fetal alcohol spectrum disorders based upon expert consensus. ( 27655132 )
2016
13
Special Education of Children with Fetal Alcohol Spectrum Disorder. ( 27695197 )
2016
14
Dysregulation of TrkB phosphorylation and proBDNF protein in adenylyl cyclase 1 and 8 knockout mice in a model of fetal alcohol spectrum disorder. ( 26992697 )
2016
15
Fetal alcohol spectrum disorder: reconsidering blame. ( 26811363 )
2016
16
Modeling Fetal Alcohol Spectrum Disorder: Validating an Ex Vivo Primary Hippocampal Cell Culture System. ( 27162054 )
2016
17
Hippocampal hyperexcitability in fetal alcohol spectrum disorder: Pathological sharp waves and excitatory/inhibitory synaptic imbalance. ( 26996134 )
2016
18
Prevention of Fetal Alcohol Spectrum Disorder: Current Canadian Efforts and Analysis of Gaps. ( 27199560 )
2016
19
Social perception in children with fetal alcohol spectrum disorder. ( 27829119 )
2016
20
Immediate Neural Plasticity Involving Reaction Time in a Saccadic Eye Movement Task is Intact in Children With Fetal Alcohol Spectrum Disorder. ( 27716964 )
2016
21
1 in 100 babies: the fetal alcohol spectrum disorder pathway. ( 27892236 )
2016
22
Developmental and behavioral consequences of early life maternal separation stress in a mouse model of fetal alcohol spectrum disorder. ( 27102339 )
2016
23
Adults with Fetal Alcohol Spectrum Disorder: Factors Associated with Positive Outcomes and Contact with the Criminal Justice System. ( 26962847 )
2016
24
Graphomotor skills in children with prenatal alcohol exposure and fetal alcohol spectrum disorder: A population-based study in remote Australia. ( 27646500 )
2016
25
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. ( 26608087 )
2016
26
Cost attributable to Fetal Alcohol Spectrum Disorder in the Canadian correctional system. ( 25846557 )
2015
27
Selective reduction of cerebral cortex GABA neurons in a late gestation model of fetal alcohol spectrum disorder. ( 26252988 )
2015
28
DNA methylation changes in fetal alcohol spectrum disorder. ( 26531658 )
2015
29
Verbal learning and memory impairment in children with fetal alcohol spectrum disorders. ( 25833031 )
2015
30
Fetal alcohol spectrum disorder: molecular insights into neural damage reduction. ( 26807109 )
2015
31
Sex-related differences in auditory processing in adolescents with fetal alcohol spectrum disorder: A magnetoencephalographic study. ( 26082886 )
2015
32
The Medical Symptom Validity Test Measures Effort Not Ability in Children: A Comparison Between Mild TBI and Fetal Alcohol Spectrum Disorder Samples. ( 25787156 )
2015
33
Systematic Review of Fetal Alcohol Spectrum Disorder Interventions Across the Life Span. ( 26578111 )
2015
34
The Economic Burden of Fetal Alcohol Spectrum Disorder in Canada in 2013. ( 26493100 )
2015
35
Self-regulation therapy increases frontal gray matter in children with fetal alcohol spectrum disorder: evaluation by voxel-based morphometry. ( 25788884 )
2015
36
Performance- and questionnaire-based tools for the evaluation of executive function in children and adolescents with fetal alcohol spectrum disorder. ( 26531491 )
2015
37
Canadian media discourse about Fetal Alcohol Spectrum Disorder. ( 26531619 )
2015
38
Pharmacological Treatment of Disruptive Behavior in Children with Fetal Alcohol Spectrum Disorder. ( 25634057 )
2015
39
Costs of Fetal Alcohol Spectrum Disorder in the Canadian Criminal Justice System. ( 26072470 )
2015
40
Eye movements reveal sexually dimorphic deficits in children with fetal alcohol spectrum disorder. ( 25814922 )
2015
41
Anticipatory guidance for children and adolescents with Fetal Alcohol Spectrum Disorder (FASD): practice points for primary health care providers. ( 25599159 )
2015
42
Studying public knowledge of risk of prenatal alcohol exposure is not the same as knowledge of fetal alcohol spectrum disorder (FASD). ( 26079419 )
2015
43
The cost of lost productivity due to fetal alcohol spectrum disorder-related premature mortality. ( 25594934 )
2015
44
Fetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids Signaling. ( 26529026 )
2015
45
Guided Internet-Based Parent Training for Challenging Behavior in Children With Fetal Alcohol Spectrum Disorder (Strongest Families FASD): Study Protocol for a Randomized Controlled Trial. ( 26462968 )
2015
46
Pathological sharp waves and hyperexcitability in a mouse model of Fetal Alcohol Spectrum Disorder (FASD). ( 26531371 )
2015
47
Central nervous system deficits in fetal alcohol spectrum disorder. ( 25774812 )
2015
48
An in-depth analysis of saccade metrics in children with fetal alcohol spectrum disorder (FASD). ( 26531483 )
2015
49
Deficits in response inhibition correlate with oculomotor control in children with fetal alcohol spectrum disorder and prenatal alcohol exposure. ( 24185031 )
2014
50
Productivity losses because of morbidity attributable to fetal alcohol spectrum disorder in Canada: a demographic approach. ( 25343659 )
2014

Variations for Fetal Alcohol Spectrum Disorder

Expression for Fetal Alcohol Spectrum Disorder

Search GEO for disease gene expression data for Fetal Alcohol Spectrum Disorder.

Pathways for Fetal Alcohol Spectrum Disorder

Pathways related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.25 ADH6 ADH7 AKR1A1 ALDH9A1
2
Show member pathways
11.88 ADH6 AKR1A1 ALDH9A1
3
Show member pathways
11.5 BDNF GRIN2A GRIN2B
4
Show member pathways
11.3 ADH6 ADH7 ALDH9A1
5
Show member pathways
11.01 ADH6 ADH7 ALDH9A1
6 10.9 GRIN2A GRIN2B
7 10.87 GRIN2A GRIN2B
8 10.64 GRIN2A GRIN2B
9
Show member pathways
10.29 ADH6 ADH7 AKR1A1

GO Terms for Fetal Alcohol Spectrum Disorder

Cellular components related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 NMDA selective glutamate receptor complex GO:0017146 8.62 GRIN2A GRIN2B

Biological processes related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.77 ADH6 ADH7 AKR1A1 ALDH9A1 DIO3
2 retinol metabolic process GO:0042572 9.43 ADH7 RBP1
3 ionotropic glutamate receptor signaling pathway GO:0035235 9.4 GRIN2A GRIN2B
4 retinoic acid metabolic process GO:0042573 9.32 ADH7 RBP1
5 glutamate receptor signaling pathway GO:0007215 9.26 GRIN2A GRIN2B
6 ethanol oxidation GO:0006069 9.16 ADH6 ADH7
7 cellular aldehyde metabolic process GO:0006081 8.96 AKR1A1 ALDH9A1
8 response to ethanol GO:0045471 8.92 ADH6 ADH7 GRIN2A GRIN2B

Molecular functions related to Fetal Alcohol Spectrum Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.72 ADH6 ADH7 AKR1A1 ALDH9A1 DIO3
2 ionotropic glutamate receptor activity GO:0004970 9.4 GRIN2A GRIN2B
3 extracellular-glutamate-gated ion channel activity GO:0005234 9.37 GRIN2A GRIN2B
4 retinol binding GO:0019841 9.26 ADH7 RBP1
5 alcohol dehydrogenase (NAD) activity GO:0004022 9.16 ADH6 ADH7
6 NMDA glutamate receptor activity GO:0004972 8.96 GRIN2A GRIN2B
7 alcohol dehydrogenase activity, zinc-dependent GO:0004024 8.62 ADH6 ADH7

Sources for Fetal Alcohol Spectrum Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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