FAS
MCID: FTL006
MIFTS: 64

Fetal Alcohol Spectrum Disorder (FAS) malady

Rare diseases, Neuronal diseases, Fetal diseases categories
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Summaries for Fetal Alcohol Spectrum Disorder

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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Fully expand this MalaCard
MedlinePlus:34 Alcohol can harm your baby at any stage during a pregnancy. that includes the earliest stages before you even know you are pregnant. drinking alcohol can cause a group of conditions called fetal alcohol spectrum disorders (fasds).effects can include physical and behavioral problems such as trouble with learning and remembering understanding and following directions controlling emotions communicating and socializing daily life skills, such as feeding and bathing fetal alcohol syndrome is the most serious type of fasd. people with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. fasds last a lifetime. there is no cure for fasds. treatments can help. these include medicines to help with some symptoms and behavior therapy. no one treatment is right for every child. centers for disease control and prevention

MalaCards: Fetal Alcohol Spectrum Disorder, also known as fetal alcohol syndrome, is related to lung cancer and colon cancer, and has symptoms including low set ears/posteriorly rotated ears, vertebral segmentation anomaly/hemivertebrae and abnormal dermatoglyphics. An important gene associated with Fetal Alcohol Spectrum Disorder is KCNK9 (potassium channel, subfamily K, member 9), and among its related pathways are FSH signaling pathway and BDNF signaling pathway. The drugs chlordiazepoxide and citalopram and the compounds 3-nitropropionic acid and quisqualate have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and brain, and related mouse phenotypes are normal and respiratory system.

Disease Ontology:8 A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.

Wikipedia:65 Fetal alcohol spectrum disorders (FASD) is a continuum of various permanent birth defects caused by the... more...

Aliases & Classifications for Fetal Alcohol Spectrum Disorder

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
fetal alcohol syndrome:
Inheritance: Sporadic; Age of onset: Neonatal/infancy; Age of death: Any age


Aliases & Descriptions:

fetal alcohol spectrum disorder 8 10 62
fetal alcohol syndrome 10 45 49 62
fetal alcohol spectrum disorders 43 49 34
alcohol-related neurodevelopmental disorder 10 49
fasd 43 49
alcohol-related neurodevelopmental disorder - type 43
alcohol related neurodevelopmental disorder 62
alcohol-related birth defects - type 43
alcoholic intoxication, chronic 62
fetal alcohol syndrome - type 43
alcohol-related birth defects 49
arnd 49
arbd 49
fas 49


External Ids:

Disease Ontology8 DOID:0050696
MESH via Orphanet36 D005310
ICD10 via Orphanet26 Q86.0
SNOMED-CT via Orphanet59 205788004
UMLS via Orphanet63 C0015923
ICD1025 Q86.0

Related Diseases for Fetal Alcohol Spectrum Disorder

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Fetal Alcohol Spectrum Disorder family:

Fetal Alcohol Syndrome

Diseases related to Fetal Alcohol Spectrum Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 473)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.7CREB1, ALDH9A1, SRF
2colon cancer30.7SRF, ALDH9A1, CREB1
3systemic lupus erythematosus30.7SRF, CREB1, BDNF
4hepatocellular carcinoma30.7BDNF, CREB1, ALDH9A1, SRF
5adenocarcinoma30.7SRF, ALDH9A1, CREB1, BDNF
6rheumatoid arthritis30.6BDNF, CREB1, SRF
7neuroblastoma30.5BDNF
8alzheimer's disease30.3ALDH9A1, CREB1, BDNF
9alcohol abuse30.3CREB1, ALDH9A1
10memory impairment30.3BDNF, CREB1
11huntington's disease29.8BDNF, CREB1
12leukemia10.8
13hepatitis10.7
14thyroiditis10.7
15prostatitis10.6
16fetal alcohol syndrome10.6
17melanoma10.6
18autoimmune lymphoproliferative syndrome10.6
19breast cancer10.6
20lupus erythematosus10.5
21prostate cancer10.5
22attention deficit hyperactivity disorder10.5
23esophagitis10.5
24hepatitis c10.5
25myeloma10.5
26arthritis10.5
27pancreatitis10.5
28cervicitis10.5
29renal cell carcinoma10.5
30osteosarcoma10.5
31autoimmune lymphoproliferative syndrome, type ib10.5
32silicosis10.4
33obesity10.4
34autism spectrum disorder10.4
35myeloid leukemia10.4
36autoimmune thyroiditis10.4
37hepatitis b10.4
38colorectal cancer10.4
39multiple myeloma10.4
40hiv-110.4
41t-cell leukemia10.4
42graft versus host disease10.4
43cervical cancer10.4
44ovarian cancer10.4
45b-cell lymphomas10.4
46cholangiocarcinoma10.3
47cutaneous t cell lymphoma10.3
48sarcoma10.3
49viral hepatitis10.3
50neuronitis10.3

Graphical network of the top 20 diseases related to Fetal Alcohol Spectrum Disorder:



Diseases related to fetal alcohol spectrum disorder

Symptoms for Fetal Alcohol Spectrum Disorder

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Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 31)
  • low set ears/posteriorly rotated ears
  • vertebral segmentation anomaly/hemivertebrae
  • abnormal dermatoglyphics
  • atrial septal defect/interauricular communication
  • visceral angiomatosis (excluding skin)
  • restricted joint mobility/joint stiffness/ankylosis
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • cleft palate without cleft lip/submucosal cleft palate/bifid uvula
  • hirsutism/hypertrichosis/increased body hair
  • diaphragmatic hernia/defect/agenesis
  • stillbirth/neonatal death
  • complete/partial microdontia
  • lateral cleft lip/gingival cleft/paramedian nasal cleft
  • philtrum flat/large/featureless/absent cupidon bows
  • narrow face
  • telecanthus/canthal dystopy
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • psychic/behavioural troubles
  • short stature/dwarfism/nanism
  • intrauterine growth retardation
  • antenatal exposure : alcohol
  • narrow forehead
  • micrognathia/retrognathia/micrognathism/retrognathism
  • anophthalmos/anophthalmia/microphthalmos/microphthalmia
  • strabismus/squint
  • ptosis
  • epicanthic folds
  • short/small nose
  • anteverted nares/nostrils
  • thin/retracted lips
  • microcephaly

Drugs & Therapeutics for Fetal Alcohol Spectrum Disorder

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Fetal Alcohol Spectrum Disorder

Search NIH Clinical Center for Fetal Alcohol Spectrum Disorder

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Fetal Alcohol Spectrum Disorder

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Anatomical Context for Fetal Alcohol Spectrum Disorder

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Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Fetal Alcohol Spectrum Disorder:

33
Eye, Skin, Brain, Testes, Cerebellum, Placenta

Animal Models for Fetal Alcohol Spectrum Disorder or affiliated genes

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Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Fetal Alcohol Spectrum Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.6BDNF, CREB1, SRF, KCNK9
2MP:00053888.3BDNF, CREB1, SRF, KCNK9

Publications for Fetal Alcohol Spectrum Disorder

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Sources:
52PubMed
See all sources

Articles related to Fetal Alcohol Spectrum Disorder:

(show top 50)    (show all 131)
idTitleAuthorsYear
1
Fetal alcohol spectrum disorder--poverty trap? (23458991)
2013
2
Clinical correlates of fetal alcohol spectrum disorder among diagnosed individuals in a rural diagnostic clinic. (24163155)
2013
3
Autism spectrum disorder and fetal alcohol spectrum disorder. Part II: a qualitative comparison of parenting stress. (23672659)
2013
4
Counting fetal alcohol spectrum disorder in Australia: the evidence and the challenges. (23617437)
2013
5
Inappropriate Feeding Behaviors and Dietary Intakes in Children with Fetal Alcohol Spectrum Disorder or Probable Prenatal Alcohol Exposure. (24164456)
2013
6
Altered accuracy of saccadic eye movements in children with fetal alcohol spectrum disorder. (23578065)
2013
7
Adopted children from the former Soviet Union: are they at risk of fetal alcohol spectrum disorder? (24130279)
2013
8
Identifying the neurobehavioral phenotype of fetal alcohol spectrum disorder in young children. (24163185)
2013
9
Diffusion tensor imaging correlates of saccadic reaction time in children with fetal alcohol spectrum disorder. (23551175)
2013
10
Evaluating the Psycholegal Abilities of Young Offenders With Fetal Alcohol Spectrum Disorder. (23834387)
2013
11
Fate analysis of adult hippocampal progenitors in a murine model of fetal alcohol spectrum disorder (FASD). (24040071)
2013
12
Sensory processing and ADHD in children with fetal alcohol spectrum disorder. (22439293)
2012
13
The effectiveness of a community-based intervention program for women at-risk for giving birth to a child with Fetal Alcohol Spectrum Disorder (FASD). (20694802)
2012
14
Glycosylation defects underlying fetal alcohol spectrum disorder: a novel pathogenetic model. "When the wine goes in, strange things come out" - S.T. Coleridge, The Piccolomini. (22134542)
2012
15
Ethical considerations when communicating a diagnosis of a fetal alcohol spectrum disorder to a child. (23077138)
2012
16
Sleep and sensory characteristics in young children with fetal alcohol spectrum disorder. (21654404)
2011
17
Diffusion tensor imaging of the cerebellum and eyeblink conditioning in fetal alcohol spectrum disorder. (21790667)
2011
18
Mental health issues in fetal alcohol spectrum disorder. (21780939)
2011
19
Changes in health professionals' knowledge, attitudes and practice following provision of educational resources about prevention of prenatal alcohol exposure and fetal alcohol spectrum disorder. (21649674)
2011
20
The Canadian guidelines and the interdisciplinary clinical capacity of Canada to diagnose fetal alcohol spectrum disorder. (22124027)
2011
21
Paediatricians' knowledge, attitudes and practice following provision of educational resources about prevention of prenatal alcohol exposure and Fetal Alcohol Spectrum Disorder. (21449899)
2011
22
Differentiating attention deficits in children with fetal alcohol spectrum disorder or attention-deficit-hyperactivity disorder. (19549201)
2010
23
Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disorders. (20164336)
2010
24
Alcohol-induced facial dysmorphology in C57BL/6 mouse models of fetal alcohol spectrum disorder. (20570474)
2010
25
The preventive effect of oral EGCG in a fetal alcohol spectrum disorder mouse model. (20659071)
2010
26
Profile of the first 1,400 patients receiving diagnostic evaluations for fetal alcohol spectrum disorder at the Washington State Fetal Alcohol Syndrome Diagnostic & Prevention Network. (20335648)
2010
27
Concordance of three methods for palpebral fissure length measurement in the assessment of fetal alcohol spectrum disorder. (19372601)
2009
28
Fetal alcohol syndrome and fetal alcohol spectrum disorder in Indigenous schoolchildren. (19296803)
2009
29
Costs of fetal alcohol spectrum disorder in Alberta, Canada. (19151424)
2009
30
Fetal alcohol spectrum disorder(FASD. (20012791)
2009
31
Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migration. (19393862)
2009
32
Diagnosing fetal alcohol spectrum disorder: History, challenges and future directions. (20357921)
2009
33
Potential role of the placenta in fetal alcohol spectrum disorder. (19127948)
2009
34
Modulation of glutamatergic transmission by sulfated steroids: role in fetal alcohol spectrum disorder. (17597219)
2008
35
Acid-sensitive channel inhibition prevents fetal alcohol spectrum disorders cerebellar Purkinje cell loss. (18509098)
2008
36
Development of Canadian screening tools for fetal alcohol spectrum disorder. (18840921)
2008
37
Knowledge and attitudes of criminal justice professionals in relation to Fetal Alcohol Spectrum Disorder. (18678920)
2008
38
The effect of rehearsal training on working memory span of children with fetal alcohol spectrum disorder. (17317098)
2008
39
Re-examining the core features of autism: a comparison of autism spectrum disorder and fetal alcohol spectrum disorder. (17995487)
2007
40
Fetal alcohol spectrum disorder prevention approaches among Canadian physicians by proportion of Native/Aboriginal patients: practices during the preconception and prenatal periods. (17243020)
2007
41
Research-based interventions for children and youth with a Fetal Alcohol Spectrum Disorder: revealing the gap. (17584393)
2007
42
Knowledge and attitudes about fetal alcohol syndrome, fetal alcohol spectrum disorders, and alcohol use during pregnancy by occupational therapists in the Midwest. (19759993)
2007
43
Challenges of diagnosis in fetal alcohol syndrome and fetal alcohol spectrum disorder in the adult. (17640043)
2007
44
A state of double jeopardy: impact of prenatal alcohol exposure and adverse environments on the social communicative abilities of school-age children with fetal alcohol spectrum disorder. (17428958)
2007
45
Persistence in high school: experiences of adolescents and young adults with Fetal Alcohol Spectrum Disorder. (17178534)
2006
46
Neurobehavioral functioning in children with fetal alcohol spectrum disorder. (16952890)
2006
47
Alcohol is a potent stimulant of immature neuronal networks: implications for fetal alcohol spectrum disorder. (16000153)
2005
48
Fetal alcohol spectrum disorder. (14638655)
2003
49
Fetal alcohol spectrum disorder - New diagnostic initiatives. (20046284)
2002
50
Clinical implications of a link between fetal alcohol spectrum disorder and attention-deficit hyperactivity disorder. (12025433)
2002

Variations for Fetal Alcohol Spectrum Disorder

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Expression for genes affiliated with Fetal Alcohol Spectrum Disorder

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Fetal Alcohol Spectrum Disorder

Search GEO for disease gene expression data for Fetal Alcohol Spectrum Disorder.

Pathways for genes affiliated with Fetal Alcohol Spectrum Disorder

About this section
Sources:
50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 55Reactome, 30KEGG, 57SinoBiological, 54R&D Systems, 5Cell Signaling Technology
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Pathways related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CREB1, BDNF
29.5CREB1, BDNF
3
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.5BDNF, CREB1
4
Show member pathways
9.5BDNF, CREB1
5
Show member pathways
9.5BDNF, CREB1
6
Show member pathways
9.4CREB1, SRF
7
Show member pathways
9.4CREB1, SRF
89.4CREB1, SRF
99.4CREB1, SRF
109.4CREB1, SRF
11
Show member pathways
9.4CREB1, SRF
129.4CREB1, SRF
13
Show member pathways
9.4SRF, CREB1
149.1CREB1, ALDH9A1
15
Show member pathways
9.1KCNK9, CREB1, BDNF
16
Show member pathways
9.1KCNK9, CREB1, BDNF
17
Show member pathways
mitochondrial L-carnitine shuttle pathway38
Saturated fatty acid biosynthesis60
9.0ALDH9A1, ADH6
18
Show member pathways
glycolysis38
gluconeogenesis38
Glycolysis and Gluconeogenesis38
9.0ADH6, ALDH9A1
19
Show member pathways
9.0BDNF, CREB1, SRF
20
Show member pathways
9.0SRF, CREB1, BDNF
21
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0BDNF, CREB1, SRF

Compounds for genes affiliated with Fetal Alcohol Spectrum Disorder

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 3BitterDB
See all sources

Compounds related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
13-nitropropionic acid459.9CREB1, BDNF
2quisqualate45 1110.9BDNF, CREB1
3antidepressants519.9BDNF, CREB1
4pilocarpine45 29 1111.9BDNF, SRF
5bisindolylmaleimide459.8BDNF, CREB1
6desipramine45 51 1111.8CREB1, BDNF
7methamphetamine45 51 1111.8CREB1, BDNF
8valproate459.8CREB1, BDNF
9risperidone45 51 29 61 24 1114.7CREB1, BDNF
106-hydroxydopamine459.7BDNF, CREB1
11fluoxetine45 51 29 1112.7BDNF, CREB1
12citalopram45 51 24 1112.6CREB1, BDNF
13dopac459.6BDNF, ALDH9A1
14daidzein459.5ALDH9A1, SRF
15betaine aldehyde45 2410.5ADH6, ALDH9A1
163a,7a-Dihydroxy-5b-cholestan-26-al249.4ADH6, ALDH9A1
17k252a459.4BDNF, CREB1, SRF
18dbc-amp459.4BDNF, CREB1, SRF
19imipramine45 29 51 24 1113.4BDNF, CREB1
20lysine459.4BDNF, SRF, KCNK9
21agar459.4SRF, CREB1, BDNF
22nmda45 2910.3BDNF, CREB1, SRF
23histamine45 29 2411.3BDNF, CREB1, SRF
24acetylcholine45 51 29 24 1113.3BDNF, CREB1, SRF
25estradiol45 24 1111.3BDNF, CREB1, SRF
26forskolin45 51 1111.3BDNF, CREB1, SRF
27acetaldehyde29 45 2411.3ADH6, ALDH9A1
28spermine29 45 24 1112.2ALDH9A1, SRF
29levodopa45 1110.1ALDH9A1, CREB1, BDNF
30gaba459.1BDNF, CREB1, ALDH9A1
31n acetylcysteine459.1ALDH9A1, CREB1, BDNF
324-hydroxynonenal45 2410.0CREB1, ALDH9A1, SRF
33retinoid459.0SRF, ALDH9A1, CREB1
34choline45 24 1111.0BDNF, ALDH9A1, ADH6
35cycloheximide459.0BDNF, CREB1, SRF
36dopamine45 29 24 1112.0BDNF, CREB1, ALDH9A1
37ethanol45 51 24 1111.9ADH6, ALDH9A1, BDNF
38genistein45 29 61 3 24 1113.9SRF, ALDH9A1, CREB1
39zinc45 249.8BDNF, CREB1, SRF, ADH6
40adenylate458.7ALDH9A1, CREB1, BDNF
41cyclic amp45 249.7BDNF, CREB1, SRF
42norepinephrine45 24 1110.6BDNF, CREB1, ALDH9A1, SRF
43lactate458.6SRF, ALDH9A1, CREB1, BDNF
44testosterone45 61 24 1111.6SRF, ALDH9A1, CREB1, BDNF
45retinoic acid45 249.5BDNF, CREB1, ALDH9A1, SRF
46lipid458.5SRF, ALDH9A1, CREB1, BDNF
47nadph45 249.5ADH6, SRF, ALDH9A1, BDNF
48vitamin a45 24 1110.4CREB1, ALDH9A1, SRF, ADH6
49serine458.3BDNF, CREB1, ALDH9A1, SRF
50glutamate458.2KCNK9, SRF, ALDH9A1, CREB1, BDNF

GO Terms for genes affiliated with Fetal Alcohol Spectrum Disorder

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Sources:
16Gene Ontology
See all sources

Cellular components related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:0080219.6BDNF, KCNK9

Biological processes related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:0016669.5BDNF, SRF
2response to hormoneGO:0097259.2BDNF, SRF

Molecular functions related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:0037059.4CREB1, SRF
2protein homodimerization activityGO:0428038.4ALDH9A1, SRF, KCNK9

Products for genes affiliated with Fetal Alcohol Spectrum Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fetal Alcohol Spectrum Disorder

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet