FASD
MCID: FTL006
MIFTS: 58

Fetal Alcohol Spectrum Disorder (FASD) malady

Fetal diseases, Neuronal diseases categories

Summaries for Fetal Alcohol Spectrum Disorder

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Alcohol can harm your baby at any stage during a pregnancy. that includes the earliest stages before you even know you are pregnant. drinking alcohol can cause a group of conditions called fetal alcohol spectrum disorders (fasds).effects can include physical and behavioral problems such as trouble with learning and remembering understanding and following directions controlling emotions communicating and socializing daily life skills, such as feeding and bathing fetal alcohol syndrome is the most serious type of fasd. people with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. fasds last a lifetime. there is no cure for fasds. treatments can help. these include medicines to help with some symptoms and behavior therapy. no one treatment is right for every child. centers for disease control and prevention

MalaCards: Fetal Alcohol Spectrum Disorder, also known as fetal alcohol syndrome, is related to alcohol abuse and alcohol dependence, and has symptoms including stillbirth/neonatal death, telecanthus/canthal dystopy and lateral cleft lip/gingival cleft/paramedian nasal cleft. An important gene associated with Fetal Alcohol Spectrum Disorder is KCNK9 (potassium channel, subfamily K, member 9), and among its related pathways are FSH signaling pathway and Validated targets of C-MYC transcriptional repression. The drugs chlordiazepoxide and citalopram and the compounds 3-nitropropionic acid and antidepressants have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and brain, and related mouse phenotypes are normal and respiratory system.

Disease Ontology:8 A physical disorder that involves physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.

Wikipedia:63 Fetal alcohol spectrum disorders (FASD) is an umbrella term which describes a continuum of permanent... more...

Aliases & Classifications for Fetal Alcohol Spectrum Disorder

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Sources:
10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
fetal alcohol syndrome:
Inheritance: Sporadic; Age of onset: Neonatal/infancy; Age of death: Any age


Aliases & Descriptions:

fetal alcohol spectrum disorder 8 10 60
fetal alcohol syndrome 10 44 48 60
fetal alcohol spectrum disorders 42 33
alcohol-related neurodevelopmental disorder - type 42
alcohol-related neurodevelopmental disorder 10
alcohol related neurodevelopmental disorder 60
alcohol-related birth defects - type 42
fetal alcohol syndrome - type 42
alcoholic intoxication, chronic 60
alcohol antenatal infection 48
fasd 42


External Ids:

Disease Ontology8 DOID:0050696
MESH via Orphanet35 D005310
ICD10 via Orphanet26 Q86.0
SNOMED-CT via Orphanet57 205788004
UMLS via Orphanet61 C0015923
ICD1025 Q86.0

Related Diseases for Fetal Alcohol Spectrum Disorder

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Fetal Alcohol Spectrum Disorder family:

Fetal Alcohol Syndrome

Diseases related to Fetal Alcohol Spectrum Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol abuse30.4CREB1, ALDH9A1
2alcohol dependence30.2ADH6
3down syndrome30.2CREB1
4fetal alcohol syndrome10.6
5attention deficit hyperactivity disorder10.5
6image syndrome10.4
7autism spectrum disorder10.4
8neuronitis10.3
9adult syndrome10.3
10speech disorder10.2
11substance abuse10.2
12wernicke-korsakoff syndrome10.1
13acute neonatal citrullinemia type i10.1
14arts syndrome10.1
15alcohol-related birth defect10.1
16alcohol-related neurodevelopmental disorder10.1
17partial fetal alcohol syndrome10.1
18amblyopia10.1
19sleep disorder10.1
20developmental disabilities10.1
21cleft palate10.1
22burns10.0
23rett syndrome10.0
24cerebritis10.0
25digeorge syndrome10.0
26sudden infant death syndrome10.0
27west syndrome10.0
28microcephaly10.0
29cleft lip10.0
30phenylketonuria10.0
31prader-willi syndrome10.0
32klippel-feil syndrome10.0
33fragile x syndrome10.0
34adrenal carcinoma10.0
35ischemia10.0
36keratoconus10.0
37learning disability10.0
38pyloric stenosis10.0
39retinoschisis10.0
40synostosis10.0
41polymicrogyria10.0
42neuroblastoma10.0BDNF
43medulloblastoma10.0ALDH9A1
44bipolar disorder10.0BDNF, CREB1
45drug addiction10.0BDNF, CREB1
46memory impairment10.0CREB1, BDNF
47mood disorder10.0BDNF, CREB1
48prion disease10.0BDNF, CREB1
49tuberculosis10.0CREB1, SRF
50systemic lupus erythematosus10.0BDNF, CREB1, SRF

Graphical network of the top 20 diseases related to Fetal Alcohol Spectrum Disorder:



Diseases related to fetal alcohol spectrum disorder

Clinical Features for Fetal Alcohol Spectrum Disorder

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Sources:
48Orphanet
See all sources


Symptoms:

48 (show all 31)
  • stillbirth/neonatal death
  • telecanthus/canthal dystopy
  • lateral cleft lip/gingival cleft/paramedian nasal cleft
  • anophthalmos/anophthalmia/microphthalmos/microphthalmia
  • intrauterine growth retardation
  • visceral angiomatosis (excluding skin)
  • narrow face
  • vertebral segmentation anomaly/hemivertebrae
  • thin/retracted lips
  • diaphragmatic hernia/defect/agenesis
  • antenatal exposure : alcohol
  • atrial septal defect/interauricular communication
  • abnormal dermatoglyphics
  • complete/partial microdontia
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • ptosis
  • psychic/behavioural troubles
  • short/small nose
  • restricted joint mobility/joint stiffness/ankylosis
  • anteverted nares/nostrils
  • philtrum flat/large/featureless/absent cupidon bows
  • short stature/dwarfism/nanism
  • microcephaly
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • cleft palate without cleft lip/submucosal cleft palate/bifid uvula
  • micrognathia/retrognathia/micrognathism/retrognathism
  • hirsutism/hypertrichosis/increased body hair
  • epicanthic folds
  • strabismus/squint
  • narrow forehead
  • low set ears/posteriorly rotated ears

Drugs & Therapeutics for Fetal Alcohol Spectrum Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Fetal Alcohol Spectrum Disorder

Drug clinical trials:

Search ClinicalTrials for Fetal Alcohol Spectrum Disorder

Search NIH Clinical Center for Fetal Alcohol Spectrum Disorder

Search CenterWatch for Fetal Alcohol Spectrum Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Fetal Alcohol Spectrum Disorder

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Anatomical Context for Fetal Alcohol Spectrum Disorder

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Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Fetal Alcohol Spectrum Disorder:

32
Eye, Skin, Brain, Placenta, Testes, Cerebellum

Animal Models for Fetal Alcohol Spectrum Disorder or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Fetal Alcohol Spectrum Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.3SRF, CREB1, BDNF, KCNK9
2MP:00053888.0SRF, CREB1, BDNF, KCNK9

Publications for Fetal Alcohol Spectrum Disorder

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Sources:
50PubMed
See all sources

Articles related to Fetal Alcohol Spectrum Disorder:

(show top 50)    (show all 132)
idTitleAuthorsYear
1
Fetal alcohol spectrum disorder--poverty trap? (23458991)
2013
2
Clinical correlates of fetal alcohol spectrum disorder among diagnosed individuals in a rural diagnostic clinic. (24163155)
2013
3
Altered accuracy of saccadic eye movements in children with fetal alcohol spectrum disorder. (23578065)
2013
4
Adopted children from the former Soviet Union: are they at risk of fetal alcohol spectrum disorder? (24130279)
2013
5
Validation of the fetal alcohol spectrum disorder (FASD) 4-Digit Diagnostic Code. (24323701)
2013
6
Fetal alcohol spectrum disorder and the law in Australia: the need for awareness and concern to translate into urgent action. (23600183)
2013
7
Use of health, education, and social services by individuals with fetal alcohol spectrum disorder. (23648378)
2013
8
Cost of fetal alcohol spectrum disorder diagnosis in Canada. (23593216)
2013
9
Sensory processing and ADHD in children with fetal alcohol spectrum disorder. (22439293)
2012
10
The effectiveness of a community-based intervention program for women at-risk for giving birth to a child with Fetal Alcohol Spectrum Disorder (FASD). (20694802)
2012
11
Neuroimmune mechanisms in fetal alcohol spectrum disorder. (22623427)
2012
12
What do we know about the economic impact of fetal alcohol spectrum disorder? A systematic literature review. (21515625)
2011
13
Feeling different: the experience of living with fetal alcohol spectrum disorder. (22042791)
2011
14
Evaluating the cost of fetal alcohol spectrum disorder. (21138723)
2011
15
Comparing Attentional Networks in fetal alcohol spectrum disorder and the inattentive and combined subtypes of attention deficit hyperactivity disorder. (21667361)
2011
16
si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorder. (21443795)
2011
17
Alcohol-induced facial dysmorphology in C57BL/6 mouse models of fetal alcohol spectrum disorder. (20570474)
2010
18
Using telehealth for assessment of fetal alcohol spectrum disorder: the experience of two Canadian rural and remote communities. (20925569)
2010
19
Brain microstructure is related to math ability in children with fetal alcohol spectrum disorder. (19930234)
2010
20
Paternal genetic contribution influences fetal vulnerability to maternal alcohol consumption in a rat model of fetal alcohol spectrum disorder. (20383339)
2010
21
Correlation between drugs of abuse and alcohol by hair analysis: parents at risk for having children with fetal alcohol spectrum disorder. (20580184)
2010
22
Managing fetal alcohol spectrum disorder in the public school system: a needs assessment pilot. (20160330)
2010
23
Concordance of three methods for palpebral fissure length measurement in the assessment of fetal alcohol spectrum disorder. (19372601)
2009
24
Costs of fetal alcohol spectrum disorder in Alberta, Canada. (19151424)
2009
25
Fetal alcohol spectrum disorder(FASD. (20012791)
2009
26
Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migration. (19393862)
2009
27
Diagnosing fetal alcohol spectrum disorder: History, challenges and future directions. (20357921)
2009
28
Voxelwise and skeleton-based region of interest analysis of fetal alcohol syndrome and fetal alcohol spectrum disorders in young adults. (19278010)
2009
29
Can attention deficit hyperactivity disorder and fetal alcohol spectrum disorder be differentiated by motor and balance deficits? (19345435)
2009
30
Three national programs address fetal alcohol spectrum disorder. (19327218)
2009
31
Development of Canadian screening tools for fetal alcohol spectrum disorder. (18840921)
2008
32
The effect of rehearsal training on working memory span of children with fetal alcohol spectrum disorder. (17317098)
2008
33
Fetal alcohol spectrum disorder-associated depression: evidence for reductions in the levels of brain-derived neurotrophic factor in a mouse model. (18558427)
2008
34
Fetal alcohol spectrum disorder: New Zealand birth mothers' experiences. (18515921)
2008
35
Brief report: lie-telling in children with fetal alcohol spectrum disorder. (17728303)
2008
36
Fetal alcohol spectrum disorder: report of one case. (18581726)
2008
37
Building clinical capacity for fetal alcohol spectrum disorder diagnoses in western and northern Canada. (18544794)
2008
38
Research-based interventions for children and youth with a Fetal Alcohol Spectrum Disorder: revealing the gap. (17584393)
2007
39
Knowledge and attitudes about fetal alcohol syndrome, fetal alcohol spectrum disorders, and alcohol use during pregnancy by occupational therapists in the Midwest. (19759993)
2007
40
A state of double jeopardy: impact of prenatal alcohol exposure and adverse environments on the social communicative abilities of school-age children with fetal alcohol spectrum disorder. (17428958)
2007
41
Novel approaches to the diagnosis of fetal alcohol spectrum disorder. (16934870)
2007
42
Cost of fetal alcohol spectrum disorder in Canada. (17872844)
2007
43
Neurobehavioral functioning in children with fetal alcohol spectrum disorder. (16952890)
2006
44
Fetal alcohol spectrum disorder: an overview. (16738372)
2006
45
Preventing fetal alcohol spectrum disorder in Aboriginal communities: a methods development project. (16398571)
2006
46
Diagnosis of fetal alcohol spectrum disorder (FASD): fatty acid ethyl esters and neonatal hair analysis. (16801724)
2006
47
Executive functioning and working memory in fetal alcohol spectrum disorder. (16131842)
2005
48
Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis. (15738468)
2005
49
Fetal alcohol spectrum disorder. (14638655)
2003
50
Clinical implications of a link between fetal alcohol spectrum disorder and attention-deficit hyperactivity disorder. (12025433)
2002

Genetic Variations for Fetal Alcohol Spectrum Disorder

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Expression for genes affiliated with Fetal Alcohol Spectrum Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Fetal Alcohol Spectrum Disorder

Search GEO for disease gene expression data for Fetal Alcohol Spectrum Disorder.

Pathways for genes affiliated with Fetal Alcohol Spectrum Disorder

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN
See all sources

Compounds for genes affiliated with Fetal Alcohol Spectrum Disorder

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
13-nitropropionic acid449.9BDNF, CREB1
2antidepressants499.9BDNF, CREB1
3quisqualate44 1110.9CREB1, BDNF
4dopac449.9BDNF, ALDH9A1
5bisindolylmaleimide449.8CREB1, BDNF
6desipramine44 49 1111.8BDNF, CREB1
7risperidone28 44 49 59 11 2414.8BDNF, CREB1
8methamphetamine44 49 1111.8BDNF, CREB1
9fluoxetine49 44 28 1112.8BDNF, CREB1
10citalopram49 44 11 2412.8BDNF, CREB1
11betaine aldehyde44 2410.8ALDH9A1, ADH6
12valproate449.8BDNF, CREB1
136-hydroxydopamine449.7CREB1, BDNF
14imipramine44 49 28 11 2413.6BDNF, CREB1
15acetaldehyde44 28 2411.6ADH6, ALDH9A1
16pilocarpine44 28 1111.5SRF, BDNF
17daidzein449.5ALDH9A1, SRF
18lithium44 49 11 2412.5CREB1, BDNF
19melatonin44 59 28 11 2413.5CREB1, BDNF
20levodopa44 1110.4BDNF, CREB1, ALDH9A1
21gaba449.4ALDH9A1, CREB1, BDNF
22n acetylcysteine449.4ALDH9A1, CREB1, BDNF
23spermine44 28 11 2412.3ALDH9A1, SRF
24choline44 11 2411.2ADH6, ALDH9A1, BDNF
25ethanol44 49 11 2412.2ADH6, ALDH9A1, BDNF
26dopamine44 28 11 2412.2ALDH9A1, CREB1, BDNF
27k252a449.1SRF, CREB1, BDNF
28dbc-amp449.1BDNF, CREB1, SRF
294-hydroxynonenal44 2410.1ALDH9A1, SRF, CREB1
30agar449.1BDNF, CREB1, SRF
31retinoid449.1CREB1, SRF, ALDH9A1
32nmda44 2810.0SRF, CREB1, BDNF
33adenylate449.0ALDH9A1, CREB1, BDNF
34histamine44 28 2411.0BDNF, CREB1, SRF
35acetylcholine44 49 28 11 2413.0SRF, CREB1, BDNF
36estradiol44 11 2411.0BDNF, CREB1, SRF
37forskolin44 49 1111.0SRF, CREB1, BDNF
38genistein44 28 59 2 11 2414.0ALDH9A1, SRF, CREB1
39lysine448.9KCNK9, BDNF, SRF
40norepinephrine44 11 2410.6ALDH9A1, SRF, CREB1, BDNF
41lactate448.6ALDH9A1, SRF, CREB1, BDNF
42cyclic amp44 249.6BDNF, CREB1, SRF
43testosterone44 59 11 2411.6BDNF, CREB1, SRF, ALDH9A1
44retinoic acid44 249.5BDNF, CREB1, SRF, ALDH9A1
45vitamin a44 11 2410.5ADH6, ALDH9A1, SRF, CREB1
46zinc44 249.5BDNF, CREB1, SRF, ADH6
47lipid448.5BDNF, CREB1, SRF, ALDH9A1
48nadph44 249.4ADH6, ALDH9A1, SRF, BDNF
49glutamate448.2KCNK9, BDNF, CREB1, SRF, ALDH9A1
50serine447.9ALDH9A1, SRF, CREB1, BDNF

GO Terms for genes affiliated with Fetal Alcohol Spectrum Disorder

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Sources:
16Gene Ontology
See all sources

Cellular components related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:0080219.5BDNF, KCNK9

Biological processes related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hormone stimulusGO:0097259.1SRF, BDNF

Molecular functions related to Fetal Alcohol Spectrum Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:0037059.2SRF, CREB1

Products for genes affiliated with Fetal Alcohol Spectrum Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fetal Alcohol Spectrum Disorder

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet