MCID: FTL001
MIFTS: 45

Fetal Alcohol Syndrome malady

Fetal diseases, Rare diseases, Neuronal diseases categories

Summaries for Fetal Alcohol Syndrome

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. the presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.

MalaCards: Fetal Alcohol Syndrome is related to fetal alcohol spectrum disorder and partial fetal alcohol syndrome. An important gene associated with Fetal Alcohol Syndrome is PFAS (phosphoribosylformylglycinamidine synthase), and among its related pathways are Glycerolipid metabolism and Abacavir Pathway, Pharmacokinetics/Pharmacodynamics. The compounds n-benzylformamide and propionaldehyde have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotype behavior/neurological.

Aliases & Classifications for Fetal Alcohol Syndrome

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Sources:
9Disease Ontology, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

fetal alcohol syndrome 9 63


External Ids:

Disease Ontology9 DOID:0050665

Related Diseases for Fetal Alcohol Syndrome

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Fetal Alcohol Spectrum Disorder family:

fetal alcohol syndrome

Diseases related to Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1fetal alcohol spectrum disorder30.9ACSS3, PVALB, AKR1A1, ADH1B, PFAS
2partial fetal alcohol syndrome30.9ACER3, PFAS
3substance abuse30.4ADH1B, ALDH2
4neuronitis10.3
5optic nerve hypoplasia10.3
6alcohol-related neurodevelopmental disorder10.2
7memory impairment10.2
8hirschsprung's disease10.1VIP
9alcohol abuse10.1ALDH2, AKR1A1
10alcoholic pancreatitis10.1ADH1B, AKR1A1, ALDH2
11alcoholic liver cirrhosis10.1ADH1B, AKR1A1, ALDH2
12pancreatitis, chronic10.0ADH1B, AKR1A1, ALDH2
13multiple system atrophy10.0PVALB, GFAP
14renal clear cell carcinoma10.0CALB2, PVALB
15liver cirrhosis10.0ALDH2, AKR1A1, ADH1B
16alcohol dependence10.0ALDH2, ADH1B, ADH1A
17viral hepatitis10.0AKR1A1, ADH1B
18adrenocortical carcinoma10.0VIP, CALB2
19ganglioneuroma10.0VIP, GFAP
20esophageal cancer10.0ALDH2, ADH1B
21galactosemia10.0ALDH2, AKR1A1, ADH1B
22temporal lobe epilepsy10.0PVALB, GFAP
23attention deficit hyperactivity disorder10.0
24burns10.0
25rett syndrome10.0
26phenylketonuria10.0
27cleft lip10.0
28microcephaly10.0
29cleft palate10.0
30prader-willi syndrome10.0
31cerebritis10.0
32digeorge syndrome10.0
33alcohol-related birth defect10.0
34sudden infant death syndrome10.0
35adrenal carcinoma10.0
36fragile x syndrome10.0
37down syndrome10.0
38ischemia10.0
39keratoconus10.0
40learning disability10.0
41pyloric stenosis10.0
42retinoschisis10.0
43synostosis10.0
44polymicrogyria10.0
45chiari malformation10.0
46ring chromosome 610.0
47schizencephaly10.0
48spondylocarpotarsal synostosis syndrome10.0
49mental retardation10.0
50head injury10.0

Graphical network of the top 20 diseases related to Fetal Alcohol Syndrome:



Diseases related to fetal alcohol syndrome

Symptoms for Fetal Alcohol Syndrome

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Drugs & Therapeutics for Fetal Alcohol Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Fetal Alcohol Syndrome

Drug clinical trials:

Search ClinicalTrials for Fetal Alcohol Syndrome

Search NIH Clinical Center for Fetal Alcohol Syndrome

Search CenterWatch for Fetal Alcohol Syndrome

Genetic Tests for Fetal Alcohol Syndrome

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Anatomical Context for Fetal Alcohol Syndrome

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Sources:
34MalaCards
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MalaCards organs/tissues related to Fetal Alcohol Syndrome:

34
Eye, Brain, Testes, Liver, Bone, Thymus, Heart, Endothelial

Animal Models for Fetal Alcohol Syndrome or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Fetal Alcohol Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.9ALDH2, CALB2, PVALB, CHRM3, VIP, GFAP

Publications for Fetal Alcohol Syndrome

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Sources:
53PubMed
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Articles related to Fetal Alcohol Syndrome:

(show top 50)    (show all 493)
idTitleAuthorsYear
1
Health care burden and cost associated with fetal alcohol syndrome: based on official Canadian data. (22900084)
2012
2
Teaching NeuroImages: Schizencephaly in fetal alcohol syndrome. (22025464)
2011
3
Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice. (21383198)
2011
4
Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate. (20451895)
2010
5
Fetal alcohol syndrome and fetal alcohol spectrum disorder in Indigenous schoolchildren. (19296803)
2009
6
Maternal risk factors for fetal alcohol syndrome and partial fetal alcohol syndrome in South Africa: a third study. (18336634)
2008
7
Automated diagnosis of fetal alcohol syndrome using 3D facial image analysis. (18713153)
2008
8
Identification of transcription factor and microRNA binding sites in responsible to fetal alcohol syndrome. (18366608)
2008
9
Impaired eyeblink conditioning in children with fetal alcohol syndrome. (18162064)
2008
10
Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome. (17200951)
2007
11
Stereo image matching for facial feature measurement to aid in fetal alcohol syndrome screening. (16904364)
2007
12
Ethanol impairs Rho GTPase signaling and differentiation of cerebellar granule neurons in a rodent model of fetal alcohol syndrome. (17109064)
2006
13
Using the past to step forward: fetal alcohol syndrome in the Western Cape Province of South Africa. (15983266)
2005
14
Fetal alcohol syndrome. Introduction. (15223535)
2004
15
Increased sibling mortality in children with fetal alcohol syndrome. (15223547)
2004
16
A comparison of fetal alcohol syndrome surveillance network and birth defects surveillance methodology in determining prevalence rates of fetal alcohol syndrome. (14703793)
2003
17
Recognition and management of fetal alcohol syndrome. (14624967)
2003
18
From the Centers for Disease Control and Prevention. Fetal alcohol syndrome--Alaska, Arizona, Colorado, and New York, 1995-1997. (12099269)
2002
19
Fetal alcohol syndrome. (20046289)
2002
20
Fetal alcohol syndrome: What you should know about drinking during pregnancy. (20046290)
2002
21
Application of the fetal alcohol syndrome facial photographic screening tool in a foster care population. (12410204)
2002
22
Midaortic syndrome associated with fetal alcohol syndrome. (12427818)
2002
23
Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome. (11303069)
2001
24
Gin Lane: did Hogarth know about fetal alcohol syndrome? (11259209)
2001
25
Physician awareness and screening for fetal alcohol syndrome. (11010122)
2000
26
Fetal alcohol syndrome in SALo Paulo, Brazil. (10563369)
1999
27
Neuropsychological comparison of alcohol-exposed children with or without physical features of fetal alcohol syndrome. (9460742)
1998
28
Bone age and growth in fetal alcohol syndrome. (9756047)
1998
29
Contribution to first-pass metabolism of ethanol and inhibition by ethanol for retinol oxidation in human alcohol dehydrogenase family--implications for etiology of fetal alcohol syndrome and alcohol-related diseases. (9652389)
1998
30
Fetal alcohol syndrome update. (9323398)
1997
31
Fetal alcohol syndrome epidemic on Manitoba reserve. (9220946)
1997
32
Fetal alcohol syndrome. (9113456)
1997
33
Variation in induction of human placental CYP2E1: possible role in susceptibility to fetal alcohol syndrome? (9194424)
1997
34
Optic nerve hypoplasia in fetal alcohol syndrome: an update. (9352281)
1997
35
Ethanol inhibition of retinoic acid synthesis as a potential mechanism for fetal alcohol syndrome. (8801166)
1996
36
A multiple-level, comprehensive approach to the prevention of fetal alcohol syndrome (FAS) and other alcohol-related birth defects (ARBD). (8557409)
1995
37
Neonatal diagnosis of fetal alcohol syndrome: not necessarily a hopeless prognosis. (8749826)
1995
38
Epidemiology of fetal alcohol syndrome in American Indians, Alaskan Natives, and Canadian Aboriginal peoples: a review of the literature. (7938391)
1994
39
Fetal alcohol syndrome: review of the literature with implications for physical therapists. (7689232)
1993
40
Fetal alcohol syndrome--United States, 1979-1992. (8479418)
1993
41
The role of alcohol dehydrogenase in retinoic acid homeostasis and fetal alcohol syndrome. (7748347)
1993
42
Corneal endothelial anomalies in the fetal alcohol syndrome. (1497528)
1992
43
Fetal alcohol syndrome: a case report of neuropsychological, MRI and EEG assessment of two children. (1443415)
1992
44
Fetal alcohol syndrome: misplaced emphasis. (2058598)
1991
45
Fetal alcohol syndrome in adolescents and adults. (2008025)
1991
46
Fetal alcohol syndrome: a description of oral motor, articulatory, short-term memory, grammatical, and semantic abilities. (2341602)
1990
47
Neuropsychological deficits in fetal alcohol syndrome and fetal alcohol effects. (2264592)
1990
48
Fetal alcohol syndrome: report of one case. (2260467)
1990
49
A cephalometric assessment of children with fetal alcohol syndrome. (2705412)
1989
50
Fetal alcohol syndrome. (3048231)
1988

Variations for Fetal Alcohol Syndrome

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Expression for genes affiliated with Fetal Alcohol Syndrome

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Fetal Alcohol Syndrome.

Pathways for genes affiliated with Fetal Alcohol Syndrome

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Sources:
51PathCards, 31KEGG, 56Reactome, 52PharmGKB, 39NCBI BioSystems Database, 61Thomson Reuters
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Pathways related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8ALDH2, AKR1A1
29.6ADH1B, ADH1A
3
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)39
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA39
tryptophan degradation39
glutaryl-CoA degradation39
serotonin degradation39
NAD de novo biosynthesis39
superpathway of melatonin degradation39
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde39
tryptophan utilization I39
melatonin degradation I39
9.5ADH1B, AKR1A1, ALDH2
4
Show member pathways
acetate conversion to acetyl-CoA39
oxidative ethanol degradation III39
ethanol degradation IV39
9.4ALDH2, ACSS3, ADH1B
5
Show member pathways
9.3ALDH2, ADH1B, ADH1A
6
Show member pathways
mitochondrial L-carnitine shuttle pathway39
Saturated fatty acid biosynthesis61
9.3ADH1A, ADH1B, ALDH2
7
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
9.3ALDH2, ADH1B, ADH1A
8
Show member pathways
glycolysis39
gluconeogenesis39
Glycolysis and Gluconeogenesis39
8.9ADH1A, ADH1B, AKR1A1, ALDH2
9
Show member pathways
8.9ALDH2, AKR1A1, ADH1B, ADH1A
10
Show member pathways
8.9ALDH2, AKR1A1, ADH1B, ADH1A
11
Show member pathways
7.2PFAS, ADH1A, ADH1B, CHRM3, AKR1A1, ACER3

Compounds for genes affiliated with Fetal Alcohol Syndrome

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 3BitterDB
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Compounds related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1n-benzylformamide46 1211.2ADH1B, AKR1A1
2propionaldehyde4610.1AKR1A1, ALDH2
3benzaldehyde46 2511.1ALDH2, AKR1A1
4glyceraldehyde46 2511.0AKR1A1, ALDH2
5rsai469.9AKR1A1, ALDH2, ADH1B
63,4-Dihydroxyphenylglycol259.9ADH1A, ADH1B
78-bromo-cyclic amp469.9VIP, GFAP
89-cis-Retinal259.8ADH1A, ADH1B
9guanylate469.8PFAS, ALDH2, VIP
10Retinal259.8ADH1B, ADH1A
11tetrodotoxin46 62 3011.7VIP, PVALB, GFAP
12betaine aldehyde46 2510.7ADH1B, ADH1A, ALDH2
133a,7a-Dihydroxy-5b-cholestan-26-al259.7ALDH2, ADH1B, ADH1A
143,4-Dihydroxymandelaldehyde259.7ADH1A, ADH1B
15nad+469.6AKR1A1, ALDH2, PVALB
161-Pentanol259.6ADH1B, AKR1A1, ADH1A
17haloperidol46 52 30 3 1213.6PVALB, VIP, AKR1A1
18Isopropyl alcohol259.6ADH1A, ADH1B, AKR1A1
191-Hexanol259.6ADH1A, AKR1A1, ADH1B
20Isobutanol259.6ADH1A, ADH1B, AKR1A1
21Propyl alcohol259.6AKR1A1, ADH1B, ADH1A
22cyanine469.6PVALB, CALB2
231-Butanol259.6ADH1B, AKR1A1, ADH1A
24verapamil46 30 52 25 1213.4AKR1A1, VIP, GFAP
25formaldehyde46 2510.4PVALB, GFAP, AKR1A1, ALDH2
26glutamine469.4ALDH2, AKR1A1, VIP, GFAP
27histamine46 30 2511.4ALDH2, VIP, AKR1A1, PVALB
28acetaldehyde30 46 2511.3ALDH2, AKR1A1, ADH1B, ADH1A
29quinolinic acid46 2510.3GFAP, CALB2, PVALB
30NADP259.3ALDH2, AKR1A1, ADH1A, ADH1B
31vitamin a46 25 1211.3AKR1A1, ADH1B, ADH1A, ALDH2
32nad30 2510.2ALDH2, AKR1A1, ADH1A, ADH1B
33nadh46 25 1211.2ADH1A, AKR1A1, ALDH2, ADH1B
34silver469.2CALB2, GFAP, PVALB
35polyacrylamide469.2ALDH2, PVALB, AKR1A1, ADH1B, GFAP
36carbachol46 30 1211.2KCNJ2, VIP, CHRM3
37arginine469.1AKR1A1, ALDH2, VIP, GFAP, KCNJ2
385-hydroxytryptamine469.0CALB2, AKR1A1, VIP, GFAP
39aspartate468.8VIP, AKR1A1, ALDH2, PVALB, GFAP, CHRM3
40cysteine468.7AKR1A1, CHRM3, ALDH2, GFAP, VIP
41acetylcholine46 52 30 25 1212.7GFAP, CALB2, PVALB, CHRM3, VIP
42gaba468.6PVALB, AKR1A1, VIP, CALB2, GFAP
43estrogen468.3AKR1A1, VIP, PVALB, GFAP, CALB2
44glutamate468.3AKR1A1, ALDH2, GFAP, VIP, PVALB, CALB2
45dopamine46 30 25 1211.1AKR1A1, GFAP, CALB2, ALDH2, PVALB, VIP
46nadph46 259.1ADH1A, CALB2, ADH1B, AKR1A1, PVALB, ALDH2
47zinc46 259.0ADH1B, PVALB, AKR1A1, GFAP, ADH1A, CALB2
48tyrosine467.9VIP, GFAP, KCNJ2, CALB2, CHRM3, PVALB
49choline46 25 129.8GFAP, CALB2, ADH1B, PVALB, CHRM3, VIP
50ethanol46 52 25 1210.4PVALB, CHRM3, ADH1B, ADH1A, GFAP, CALB2

GO Terms for genes affiliated with Fetal Alcohol Syndrome

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Sources:
17Gene Ontology
See all sources

Biological processes related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alcohol metabolic processGO:0060669.6ALDH2, ADH1A
2ethanol oxidationGO:0060699.4ALDH2, ADH1B, ADH1A
3cytosolic calcium ion homeostasisGO:0514809.2CALB2, PVALB
4xenobiotic metabolic processGO:0068059.0ALDH2, ADH1B, ADH1A
5small molecule metabolic processGO:0442818.1PFAS, ADH1A, ADH1B, CHRM3, ACER3, ALDH2

Molecular functions related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alcohol dehydrogenase activity, zinc-dependentGO:0040249.6ADH1B, ADH1A

Products for genes affiliated with Fetal Alcohol Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fetal Alcohol Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet