MCID: FTL001
MIFTS: 45

Fetal Alcohol Syndrome malady

Fetal diseases, Rare diseases, Neuronal diseases categories
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Summaries for Fetal Alcohol Syndrome

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Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. the presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.

MalaCards: Fetal Alcohol Syndrome is related to fetal alcohol spectrum disorder and partial fetal alcohol syndrome. An important gene associated with Fetal Alcohol Syndrome is PFAS (phosphoribosylformylglycinamidine synthase), and among its related pathways are Glycerolipid metabolism and Abacavir Pathway, Pharmacokinetics/Pharmacodynamics. The compounds n-benzylformamide and propionaldehyde have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotype behavior/neurological.

Aliases & Classifications for Fetal Alcohol Syndrome

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Sources:
8Disease Ontology, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

fetal alcohol syndrome 8 62


External Ids:

Disease Ontology8 DOID:0050665

Related Diseases for Fetal Alcohol Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Fetal Alcohol Spectrum Disorder family:

fetal alcohol syndrome

Diseases related to Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1fetal alcohol spectrum disorder30.9ACSS3, PVALB, AKR1A1, ADH1B, PFAS
2partial fetal alcohol syndrome30.9ACER3, PFAS
3substance abuse30.4ADH1B, ALDH2
4neuronitis10.3
5optic nerve hypoplasia10.3
6alcohol-related neurodevelopmental disorder10.2
7memory impairment10.2
8hirschsprung's disease10.1VIP
9alcohol abuse10.1ALDH2, AKR1A1
10alcoholic pancreatitis10.1ADH1B, AKR1A1, ALDH2
11alcoholic liver cirrhosis10.1ADH1B, AKR1A1, ALDH2
12pancreatitis, chronic10.0ADH1B, AKR1A1, ALDH2
13multiple system atrophy10.0PVALB, GFAP
14renal clear cell carcinoma10.0CALB2, PVALB
15liver cirrhosis10.0ALDH2, AKR1A1, ADH1B
16alcohol dependence10.0ALDH2, ADH1B, ADH1A
17viral hepatitis10.0AKR1A1, ADH1B
18adrenocortical carcinoma10.0VIP, CALB2
19ganglioneuroma10.0VIP, GFAP
20esophageal cancer10.0ALDH2, ADH1B
21galactosemia10.0ALDH2, AKR1A1, ADH1B
22temporal lobe epilepsy10.0PVALB, GFAP
23attention deficit hyperactivity disorder10.0
24burns10.0
25rett syndrome10.0
26phenylketonuria10.0
27cleft lip10.0
28microcephaly10.0
29cleft palate10.0
30prader-willi syndrome10.0
31cerebritis10.0
32digeorge syndrome10.0
33alcohol-related birth defect10.0
34sudden infant death syndrome10.0
35adrenal carcinoma10.0
36fragile x syndrome10.0
37down syndrome10.0
38ischemia10.0
39keratoconus10.0
40learning disability10.0
41pyloric stenosis10.0
42retinoschisis10.0
43synostosis10.0
44polymicrogyria10.0
45chiari malformation10.0
46ring chromosome 610.0
47schizencephaly10.0
48spondylocarpotarsal synostosis syndrome10.0
49mental retardation10.0
50head injury10.0

Graphical network of the top 20 diseases related to Fetal Alcohol Syndrome:



Diseases related to fetal alcohol syndrome

Symptoms for Fetal Alcohol Syndrome

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Drugs & Therapeutics for Fetal Alcohol Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Fetal Alcohol Syndrome

Search NIH Clinical Center for Fetal Alcohol Syndrome

Genetic Tests for Fetal Alcohol Syndrome

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Anatomical Context for Fetal Alcohol Syndrome

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Sources:
33MalaCards
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MalaCards organs/tissues related to Fetal Alcohol Syndrome:

33
Eye, Brain, Testes, Liver, Bone, Thymus, Heart, Endothelial

Animal Models for Fetal Alcohol Syndrome or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Fetal Alcohol Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.9ALDH2, CALB2, PVALB, CHRM3, VIP, GFAP

Publications for Fetal Alcohol Syndrome

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Sources:
52PubMed
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Articles related to Fetal Alcohol Syndrome:

(show top 50)    (show all 493)
idTitleAuthorsYear
1
Health care burden and cost associated with fetal alcohol syndrome: based on official Canadian data. (22900084)
2012
2
Teaching NeuroImages: Schizencephaly in fetal alcohol syndrome. (22025464)
2011
3
Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice. (21383198)
2011
4
Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate. (20451895)
2010
5
Fetal alcohol syndrome and fetal alcohol spectrum disorder in Indigenous schoolchildren. (19296803)
2009
6
Maternal risk factors for fetal alcohol syndrome and partial fetal alcohol syndrome in South Africa: a third study. (18336634)
2008
7
Automated diagnosis of fetal alcohol syndrome using 3D facial image analysis. (18713153)
2008
8
Identification of transcription factor and microRNA binding sites in responsible to fetal alcohol syndrome. (18366608)
2008
9
Impaired eyeblink conditioning in children with fetal alcohol syndrome. (18162064)
2008
10
Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome. (17200951)
2007
11
Stereo image matching for facial feature measurement to aid in fetal alcohol syndrome screening. (16904364)
2007
12
Ethanol impairs Rho GTPase signaling and differentiation of cerebellar granule neurons in a rodent model of fetal alcohol syndrome. (17109064)
2006
13
Using the past to step forward: fetal alcohol syndrome in the Western Cape Province of South Africa. (15983266)
2005
14
Fetal alcohol syndrome. Introduction. (15223535)
2004
15
Increased sibling mortality in children with fetal alcohol syndrome. (15223547)
2004
16
A comparison of fetal alcohol syndrome surveillance network and birth defects surveillance methodology in determining prevalence rates of fetal alcohol syndrome. (14703793)
2003
17
Recognition and management of fetal alcohol syndrome. (14624967)
2003
18
From the Centers for Disease Control and Prevention. Fetal alcohol syndrome--Alaska, Arizona, Colorado, and New York, 1995-1997. (12099269)
2002
19
Fetal alcohol syndrome. (20046289)
2002
20
Fetal alcohol syndrome: What you should know about drinking during pregnancy. (20046290)
2002
21
Application of the fetal alcohol syndrome facial photographic screening tool in a foster care population. (12410204)
2002
22
Midaortic syndrome associated with fetal alcohol syndrome. (12427818)
2002
23
Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome. (11303069)
2001
24
Gin Lane: did Hogarth know about fetal alcohol syndrome? (11259209)
2001
25
Physician awareness and screening for fetal alcohol syndrome. (11010122)
2000
26
Fetal alcohol syndrome in SALo Paulo, Brazil. (10563369)
1999
27
Neuropsychological comparison of alcohol-exposed children with or without physical features of fetal alcohol syndrome. (9460742)
1998
28
Bone age and growth in fetal alcohol syndrome. (9756047)
1998
29
Contribution to first-pass metabolism of ethanol and inhibition by ethanol for retinol oxidation in human alcohol dehydrogenase family--implications for etiology of fetal alcohol syndrome and alcohol-related diseases. (9652389)
1998
30
Fetal alcohol syndrome update. (9323398)
1997
31
Fetal alcohol syndrome epidemic on Manitoba reserve. (9220946)
1997
32
Fetal alcohol syndrome. (9113456)
1997
33
Variation in induction of human placental CYP2E1: possible role in susceptibility to fetal alcohol syndrome? (9194424)
1997
34
Optic nerve hypoplasia in fetal alcohol syndrome: an update. (9352281)
1997
35
Ethanol inhibition of retinoic acid synthesis as a potential mechanism for fetal alcohol syndrome. (8801166)
1996
36
A multiple-level, comprehensive approach to the prevention of fetal alcohol syndrome (FAS) and other alcohol-related birth defects (ARBD). (8557409)
1995
37
Neonatal diagnosis of fetal alcohol syndrome: not necessarily a hopeless prognosis. (8749826)
1995
38
Epidemiology of fetal alcohol syndrome in American Indians, Alaskan Natives, and Canadian Aboriginal peoples: a review of the literature. (7938391)
1994
39
Fetal alcohol syndrome: review of the literature with implications for physical therapists. (7689232)
1993
40
Fetal alcohol syndrome--United States, 1979-1992. (8479418)
1993
41
The role of alcohol dehydrogenase in retinoic acid homeostasis and fetal alcohol syndrome. (7748347)
1993
42
Corneal endothelial anomalies in the fetal alcohol syndrome. (1497528)
1992
43
Fetal alcohol syndrome: a case report of neuropsychological, MRI and EEG assessment of two children. (1443415)
1992
44
Fetal alcohol syndrome: misplaced emphasis. (2058598)
1991
45
Fetal alcohol syndrome in adolescents and adults. (2008025)
1991
46
Fetal alcohol syndrome: a description of oral motor, articulatory, short-term memory, grammatical, and semantic abilities. (2341602)
1990
47
Neuropsychological deficits in fetal alcohol syndrome and fetal alcohol effects. (2264592)
1990
48
Fetal alcohol syndrome: report of one case. (2260467)
1990
49
A cephalometric assessment of children with fetal alcohol syndrome. (2705412)
1989
50
Fetal alcohol syndrome. (3048231)
1988

Variations for Fetal Alcohol Syndrome

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Expression for genes affiliated with Fetal Alcohol Syndrome

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Fetal Alcohol Syndrome.

Pathways for genes affiliated with Fetal Alcohol Syndrome

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Sources:
50PathCards, 30KEGG, 55Reactome, 51PharmGKB, 38NCBI BioSystems Database, 60Thomson Reuters
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Pathways related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8ALDH2, AKR1A1
29.6ADH1B, ADH1A
3
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)38
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA38
tryptophan degradation38
glutaryl-CoA degradation38
serotonin degradation38
NAD de novo biosynthesis38
superpathway of melatonin degradation38
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde38
tryptophan utilization I38
melatonin degradation I38
9.5ADH1B, AKR1A1, ALDH2
4
Show member pathways
acetate conversion to acetyl-CoA38
oxidative ethanol degradation III38
ethanol degradation IV38
9.4ALDH2, ACSS3, ADH1B
5
Show member pathways
9.3ALDH2, ADH1B, ADH1A
6
Show member pathways
mitochondrial L-carnitine shuttle pathway38
Saturated fatty acid biosynthesis60
9.3ADH1A, ADH1B, ALDH2
7
Show member pathways
phenylalanine utilization38
noradrenaline and adrenaline degradation38
phenylalanine degradation IV38
9.3ALDH2, ADH1B, ADH1A
8
Show member pathways
glycolysis38
gluconeogenesis38
Glycolysis and Gluconeogenesis38
8.9ADH1A, ADH1B, AKR1A1, ALDH2
9
Show member pathways
8.9ALDH2, AKR1A1, ADH1B, ADH1A
10
Show member pathways
8.9ALDH2, AKR1A1, ADH1B, ADH1A
11
Show member pathways
7.2PFAS, ADH1A, ADH1B, CHRM3, AKR1A1, ACER3

Compounds for genes affiliated with Fetal Alcohol Syndrome

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 3BitterDB
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Compounds related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1n-benzylformamide45 1111.2ADH1B, AKR1A1
2propionaldehyde4510.1AKR1A1, ALDH2
3benzaldehyde45 2411.1ALDH2, AKR1A1
4glyceraldehyde45 2411.0AKR1A1, ALDH2
5rsai459.9AKR1A1, ALDH2, ADH1B
63,4-Dihydroxyphenylglycol249.9ADH1A, ADH1B
78-bromo-cyclic amp459.9VIP, GFAP
89-cis-Retinal249.8ADH1A, ADH1B
9guanylate459.8PFAS, ALDH2, VIP
10Retinal249.8ADH1B, ADH1A
11tetrodotoxin45 61 2911.7VIP, PVALB, GFAP
12betaine aldehyde45 2410.7ADH1B, ADH1A, ALDH2
133a,7a-Dihydroxy-5b-cholestan-26-al249.7ALDH2, ADH1B, ADH1A
143,4-Dihydroxymandelaldehyde249.7ADH1A, ADH1B
15nad+459.6AKR1A1, ALDH2, PVALB
161-Pentanol249.6ADH1B, AKR1A1, ADH1A
17haloperidol45 51 29 3 1113.6PVALB, VIP, AKR1A1
18Isopropyl alcohol249.6ADH1A, ADH1B, AKR1A1
191-Hexanol249.6ADH1A, AKR1A1, ADH1B
20Isobutanol249.6ADH1A, ADH1B, AKR1A1
21Propyl alcohol249.6AKR1A1, ADH1B, ADH1A
22cyanine459.6PVALB, CALB2
231-Butanol249.6ADH1B, AKR1A1, ADH1A
24verapamil45 29 51 24 1113.4AKR1A1, VIP, GFAP
25formaldehyde45 2410.4PVALB, GFAP, AKR1A1, ALDH2
26glutamine459.4ALDH2, AKR1A1, VIP, GFAP
27histamine45 29 2411.4ALDH2, VIP, AKR1A1, PVALB
28acetaldehyde29 45 2411.3ALDH2, AKR1A1, ADH1B, ADH1A
29quinolinic acid45 2410.3GFAP, CALB2, PVALB
30NADP249.3ALDH2, AKR1A1, ADH1A, ADH1B
31vitamin a45 24 1111.3AKR1A1, ADH1B, ADH1A, ALDH2
32nad29 2410.2ALDH2, AKR1A1, ADH1A, ADH1B
33nadh45 24 1111.2ADH1A, AKR1A1, ALDH2, ADH1B
34silver459.2CALB2, GFAP, PVALB
35polyacrylamide459.2ALDH2, PVALB, AKR1A1, ADH1B, GFAP
36carbachol45 29 1111.2KCNJ2, VIP, CHRM3
37arginine459.1AKR1A1, ALDH2, VIP, GFAP, KCNJ2
385-hydroxytryptamine459.0CALB2, AKR1A1, VIP, GFAP
39aspartate458.8VIP, AKR1A1, ALDH2, PVALB, GFAP, CHRM3
40cysteine458.7AKR1A1, CHRM3, ALDH2, GFAP, VIP
41acetylcholine45 51 29 24 1112.7GFAP, CALB2, PVALB, CHRM3, VIP
42gaba458.6PVALB, AKR1A1, VIP, CALB2, GFAP
43estrogen458.3AKR1A1, VIP, PVALB, GFAP, CALB2
44glutamate458.3AKR1A1, ALDH2, GFAP, VIP, PVALB, CALB2
45dopamine45 29 24 1111.1AKR1A1, GFAP, CALB2, ALDH2, PVALB, VIP
46nadph45 249.1ADH1A, CALB2, ADH1B, AKR1A1, PVALB, ALDH2
47zinc45 249.0ADH1B, PVALB, AKR1A1, GFAP, ADH1A, CALB2
48tyrosine457.9VIP, GFAP, KCNJ2, CALB2, CHRM3, PVALB
49choline45 24 119.8GFAP, CALB2, ADH1B, PVALB, CHRM3, VIP
50ethanol45 51 24 1110.4PVALB, CHRM3, ADH1B, ADH1A, GFAP, CALB2

GO Terms for genes affiliated with Fetal Alcohol Syndrome

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Sources:
16Gene Ontology
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Biological processes related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alcohol metabolic processGO:0060669.6ALDH2, ADH1A
2ethanol oxidationGO:0060699.4ALDH2, ADH1B, ADH1A
3cytosolic calcium ion homeostasisGO:0514809.2CALB2, PVALB
4xenobiotic metabolic processGO:0068059.0ALDH2, ADH1B, ADH1A
5small molecule metabolic processGO:0442818.1PFAS, ADH1A, ADH1B, CHRM3, ACER3, ALDH2

Molecular functions related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alcohol dehydrogenase activity, zinc-dependentGO:0040249.6ADH1B, ADH1A

Products for genes affiliated with Fetal Alcohol Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fetal Alcohol Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet