MCID: FTL001
MIFTS: 44

Fetal Alcohol Syndrome malady

Summaries for Fetal Alcohol Syndrome

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. the presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.

MalaCards: Fetal Alcohol Syndrome is related to fetal alcohol spectrum disorder and partial fetal alcohol syndrome. An important gene associated with Fetal Alcohol Syndrome is PFAS (phosphoribosylformylglycinamidine synthase), and among its related pathways are ethanol degradation II and Abacavir Pathway, Pharmacokinetics/Pharmacodynamics. The compounds win 18446 and alda 1 have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotypes are craniofacial and vision/eye.

Aliases & Classifications for Fetal Alcohol Syndrome

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8Disease Ontology, 60UMLS
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Aliases & Descriptions:

fetal alcohol syndrome 8 60


External Ids:

Disease Ontology8 DOID:0050665

Related Diseases for Fetal Alcohol Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Fetal Alcohol Spectrum Disorder family:

fetal alcohol syndrome

Diseases related to Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1fetal alcohol spectrum disorder30.9AKR1A1, ADH1B, PFAS, PVALB
2partial fetal alcohol syndrome30.7ACER3, PFAS
3alcohol-related neurodevelopmental disorder30.2PFAS
4alcohol dependence30.2ADH1B, ADH6, ALDH2, ADH1A
5adult syndrome10.5
6image syndrome10.4
7neuronitis10.3
8speech disorder10.2
9alcohol abuse10.1
10cleft palate10.1
11down syndrome10.1
12substance abuse10.1
13attention deficit hyperactivity disorder10.0
14burns10.0
15rett syndrome10.0
16cerebritis10.0
17digeorge syndrome10.0
18sudden infant death syndrome10.0
19west syndrome10.0
20arts syndrome10.0
21microcephaly10.0
22cleft lip10.0
23phenylketonuria10.0
24prader-willi syndrome10.0
25klippel-feil syndrome10.0
26alcohol-related birth defect10.0
27fragile x syndrome10.0
28adrenal carcinoma10.0
29ischemia10.0
30keratoconus10.0
31learning disability10.0
32pyloric stenosis10.0
33retinoschisis10.0
34synostosis10.0
35polymicrogyria10.0
36malignant pleural mesothelioma10.0CALB2
37myocardial infarction10.0ALDH2, AKR1A1
38alcoholic pancreatitis10.0AKR1A1, ADH1B, ALDH2
39alcoholic liver cirrhosis10.0ADH1B, AKR1A1, ALDH2
40pancreatic cancer10.0VIP
41tuberculosis10.0AKR1A1
42pancreatitis, chronic10.0ADH1B, ALDH2, AKR1A1
43liver cirrhosis10.0VIP, AKR1A1, ALDH2, ADH1B
44parkinson's disease10.0PVALB, AKR1A1, ALDH2, CALB2
45squamous cell carcinoma10.0ALDH2, AKR1A1, RBP1, CALB2, ADH1B

Graphical network of the top 20 diseases related to Fetal Alcohol Syndrome:



Diseases related to fetal alcohol syndrome

Clinical Features for Fetal Alcohol Syndrome

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Drugs & Therapeutics for Fetal Alcohol Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Fetal Alcohol Syndrome

Drug clinical trials:

Search ClinicalTrials for Fetal Alcohol Syndrome

Search NIH Clinical Center for Fetal Alcohol Syndrome

Search CenterWatch for Fetal Alcohol Syndrome

Genetic Tests for Fetal Alcohol Syndrome

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Anatomical Context for Fetal Alcohol Syndrome

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32MalaCards
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MalaCards organs/tissues related to Fetal Alcohol Syndrome:

32
Eye, Brain, Testes, Liver, Bone, Thymus, Heart, Endothelial

Animal Models for Fetal Alcohol Syndrome or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Fetal Alcohol Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.4ZIC5, AKR1A1, NKD2, PFAS, DVL3, OTX2
2MP:00053919.4RBP1, PFAS, OTX2, ALDH2, ALDH1A2, ZIC5
3MP:00053909.2ZIC5, AKR1A1, NKD2, PFAS, DVL3, OTX2
4MP:00053898.8ALDH2, VIP, DIO3, DMBX1, RBP1, AKR1A1
5MP:00053868.7VIP, PVALB, ZIC5, CALB2, DMBX1, NKD2
6MP:00053788.6RBP1, DMBX1, DIO3, ZIC5, NKD2, DVL3
7MP:00036318.6PVALB, ZIC5, CALB2, DMBX1, RBP1, DVL3
8MP:00053768.5VIP, DIO3, DMBX1, RBP1, AKR1A1, DVL3
9MP:00107688.4DMBX1, DIO3, ZIC5, VIP, AKR1A1, DVL3

Publications for Fetal Alcohol Syndrome

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Sources:
50PubMed
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Articles related to Fetal Alcohol Syndrome:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
A potential molecular target for morphological defects of fetal alcohol syndrome: Kir2.1. (23756044)
2013
2
Burden of fetal alcohol syndrome in a rural West Coast area of South Africa. (23725961)
2013
3
Prevention of fetal alcohol syndrome. (24009646)
2013
4
Local fetal alcohol syndrome pioneer wins global award. (22831932)
2012
5
Characteristics and behaviors of mothers who have a child with fetal alcohol syndrome. (22001355)
2012
6
Brain disorders in fetal alcohol syndrome. (21161061)
2010
7
Fetal alcohol syndrome and fetal alcohol spectrum disorder in Indigenous schoolchildren. (19296803)
2009
8
Fetal alcohol syndrome (FAS) in C57BL/6 mice detected through proteomics screening of the amniotic fluid. (18240165)
2008
9
What human service professionals know and want to know about fetal alcohol syndrome. (18299639)
2008
10
Stereo image matching for facial feature measurement to aid in fetal alcohol syndrome screening. (16904364)
2007
11
Alcohol consumption and other maternal risk factors for fetal alcohol syndrome among three distinct samples of women before, during, and after pregnancy: the risk is relative. (15095467)
2004
12
Diagnosis of fetal alcohol syndrome (fas). (19030530)
2003
13
Prevalence of fetal alcohol syndrome in the Top End of the Northern Territory. (12969208)
2003
14
From the Centers for Disease Control and Prevention. Fetal alcohol syndrome--Alaska, Arizona, Colorado, and New York, 1995-1997. (12099269)
2002
15
Fetal alcohol syndrome. (20046289)
2002
16
Liver development in a rat model of fetal alcohol syndrome. (11991607)
2002
17
Fetal alcohol syndrome. (11157101)
2001
18
"If it burns going down... ": how focus groups can shape fetal alcohol syndrome (FAS) prevention. (11325170)
2001
19
Fetal alcohol syndrome: when the end does not justify the means. (11174638)
2001
20
American Academy of Pediatrics. Committee on Substance Abuse and Committee on Children With Disabilities. Fetal alcohol syndrome and alcohol-related neurodevelopmental disorders. (10920168)
2000
21
Incidence of fetal alcohol syndrome on the southern part of RAcunion Island (France) (10440770)
1999
22
Neuropsychological deficits in adolescents with fetal alcohol syndrome: clinical findings. (9884144)
1998
23
The role of docosahexaenoic acid in brain development and fetal alcohol syndrome. (9649756)
1998
24
A review of the neuroanatomical findings in children with fetal alcohol syndrome or prenatal exposure to alcohol. (9581638)
1998
25
Minnesota responds to fetal alcohol syndrome. (9715628)
1998
26
Fetal alcohol syndrome epidemic on Manitoba reserve. (9220946)
1997
27
Blackcurrant seed oil, zinc, and fetal alcohol syndrome. (9270175)
1997
28
Magnetic resonance imaging of brain anomalies in fetal alcohol syndrome. (9024452)
1997
29
Preventing fetal alcohol syndrome: where are we now? (8857368)
1996
30
Fetal alcohol syndrome: craniofacial and central nervous system manifestations. (8834044)
1996
31
Derangement of pyruvate dehydrogenase activity in circulating lymphocytes of a newborn with fetal alcohol syndrome. (8827118)
1996
32
Is 'herbal health tonic' safe in pregnancy; fetal alcohol syndrome revisited. (9006825)
1996
33
Loss of myelinated axons is specific to the central nervous system in a mouse model of the fetal alcohol syndrome. (8586571)
1995
34
Optic nerve hypoplasia in the fetal alcohol syndrome: a mouse model. (7649829)
1995
35
Surveillance for fetal alcohol syndrome in Colorado. (8570819)
1995
36
Update: trends in fetal alcohol syndrome--United States, 1979-1993. (7898419)
1995
37
Correlates of psychopathology and intelligence in children with fetal alcohol syndrome. (8188802)
1994
38
Optic nerve hypoplasia in an acute exposure model of the fetal alcohol syndrome. (8052190)
1994
39
Involvement of free radical mechanism in the toxic effects of alcohol: implications for fetal alcohol syndrome. (7771260)
1994
40
Klippel-Feil anomaly combined with fetal alcohol syndrome. (7866854)
1994
41
Fetal alcohol syndrome in older patients. (7748302)
1993
42
Long-term psychopathological and cognitive outcome of children with fetal alcohol syndrome. (8407775)
1993
43
Experimental fetal alcohol syndrome: proposed pathogenic basis for a variety of associated facial and brain anomalies. (1456286)
1992
44
Fetal alcohol syndrome: misplaced emphasis. (2058598)
1991
45
The Alcoholic Beverages Labeling Act of 1988. A preemptive shield against fetal alcohol syndrome claims? (1885938)
1991
46
Inhibition of retinoic acid synthesis and its implications in fetal alcohol syndrome. (1877744)
1991
47
Duane's retraction syndrome in the fetal alcohol syndrome. (2240143)
1990
48
Renal tubular dysfunction in fetal alcohol syndrome. (2206881)
1990
49
Craniofacial and oral manifestations of fetal alcohol syndrome. (2315390)
1990
50
Cardiac mitochondrial abnormalities in a mouse model of the fetal alcohol syndrome. (2897803)
1988

Genetic Variations for Fetal Alcohol Syndrome

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Expression for genes affiliated with Fetal Alcohol Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Fetal Alcohol Syndrome.

Pathways for genes affiliated with Fetal Alcohol Syndrome

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 4Cell Signaling Technology, 29KEGG, 53Reactome, 12EMD Millipore
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Pathways related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ADH1B, ALDH2
210.1ADH1B, ADH1A
3
Hide members
10.1ADH1A, ADH1B
4
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10.0ALDH2, ADH1B, ADH6
59.9OTX2, DVL3, NKD2
69.9ZIC5, DMBX1, DVL3
7
Hide members
9.9ADH1A, ADH1B, ADH6
89.7ADH1A, ALDH1A2, RBP1
9
Hide members
9.7ADH6, ADH1B, ALDH2, AKR1A1
10
Hide members
9.7ADH6, ADH1B, ADH1A, ALDH1A2
11
Hide members
9.7ADH6, ADH1B, ADH1A, ALDH2
12
Hide members
9.7ALDH2, ADH1A, ADH1B, ADH6
13
Hide members
9.5ADH6, ADH1B, ADH1A, ALDH2, AKR1A1
14
Hide members
9.5ADH6, ADH1B, ADH1A, ALDH2, AKR1A1
15
Hide members
9.5AKR1A1, ALDH2, ADH1A, ADH1B, ADH6
16
Hide members
9.3ACER3, ALDH2, ALDH1A2, ADH1A, ADH1B, ADH6

Compounds for genes affiliated with Fetal Alcohol Syndrome

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Sources:
59Tocris Bioscience, 44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1win 184465910.5ALDH2, ALDH1A2
2alda 15910.5ALDH2, ALDH1A2
3n-benzylformamide44 1111.5AKR1A1, ADH1B
4decanal44 2411.4ALDH2, ALDH1A2
54-Iodopyrazole1110.4ADH1A, ADH1B
6propionaldehyde4410.3AKR1A1, ALDH2
7Fomepizole1110.3ADH1B, ADH1A
8cyanine4410.3PVALB, CALB2
9benzaldehyde44 2411.3ALDH2, AKR1A1
10rsai4410.3ADH1B, ALDH2, AKR1A1
11glyceraldehyde44 2411.3ALDH2, AKR1A1
12retinaldehyde4410.2ALDH1A2, ALDH2, RBP1
13abacavir44 49 1112.2ADH6, AKR1A1
14betaine aldehyde44 2411.1ALDH2, ADH1A, ADH1B, ADH6
15guanylate4410.0VIP, PFAS, ALDH2
16benzyl alcohol44 1111.0ALDH2, AKR1A1
17haloperidol44 28 2 49 1114.0VIP, PVALB, AKR1A1
18polyacrylamide4410.0ADH1B, ALDH2, AKR1A1, PVALB
19glycerol44 11 2411.9AKR1A1, ADH1A, ADH1B, ADH6
20nad+449.9ALDH2, AKR1A1, RBP1, PVALB
21Nicotinamide-Adenine-Dinucleotide119.9AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B
22gaba449.8VIP, PVALB, CALB2, AKR1A1
235-hydroxytryptamine449.8AKR1A1, CALB2, VIP
24hydride449.8ALDH2, AKR1A1
25histamine44 28 2411.8ALDH2, AKR1A1, PVALB, VIP
26acetaldehyde44 28 2411.7ADH6, AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B
27retinoid449.7RBP1, AKR1A1, ALDH2, ALDH1A2, ADH1A
28nad28 2410.7AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B, ADH6
29nadh44 11 2411.7AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B, ADH6
30dopamine44 28 11 2412.6VIP, PVALB, CALB2, AKR1A1, ALDH2, ADH1B
31choline44 11 2411.6VIP, PVALB, CALB2, ADH1A, ADH1B, ADH6
32zinc44 2410.4PVALB, CALB2, AKR1A1, ADH1A, ADH1B, ADH6
33vitamin a44 11 2411.4RBP1, AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B
34ethanol44 49 11 2412.1PVALB, CALB2, RBP1, AKR1A1, ALDH2, ADH1A
35nadph44 2410.1PVALB, CALB2, RBP1, AKR1A1, ALDH2, ADH1A

GO Terms for genes affiliated with Fetal Alcohol Syndrome

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16Gene Ontology
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Biological processes related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hindbrain developmentGO:03090210.2ALDH1A2, EN2
2vitamin A metabolic processGO:00677610.0RBP1, ALDH1A2
3alcohol metabolic processGO:0060669.9ALDH2, ADH1A
4ethanol oxidationGO:0060699.8ADH6, ADH1B, ADH1A, ALDH2
5xenobiotic metabolic processGO:0068059.8ALDH2, ADH1A, ADH1B, ADH6
6small molecule metabolic processGO:0442818.8DIO3, PFAS, ACER3, ALDH2, ADH1A, ADH1B

Molecular functions related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinal bindingGO:01691810.0ALDH1A2, RBP1
2alcohol dehydrogenase activity, zinc-dependentGO:00402410.0ADH1B, ADH1A
3alcohol dehydrogenase (NAD) activityGO:0040229.7ADH6, ADH1A

Products for genes affiliated with Fetal Alcohol Syndrome

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Sources for Fetal Alcohol Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet