MCID: FTL001
MIFTS: 45

Fetal Alcohol Syndrome malady

Fetal diseases, Rare diseases, Neuronal diseases categories
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Summaries for Fetal Alcohol Syndrome

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Disease Ontology:8 A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. the presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.

MalaCards based summary: Fetal Alcohol Syndrome is related to partial fetal alcohol syndrome and substance abuse. An important gene associated with Fetal Alcohol Syndrome is PFAS (phosphoribosylformylglycinamidine synthase), and among its related pathways are Glycerolipid metabolism and Abacavir Pathway, Pharmacokinetics/Pharmacodynamics. The compounds n-benzylformamide and propionaldehyde have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotype behavior/neurological.

Aliases & Classifications for Fetal Alcohol Syndrome

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Fetal Alcohol Syndrome, Aliases & Descriptions:

Name: Fetal Alcohol Syndrome 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:0050665

Related Diseases for Fetal Alcohol Syndrome

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Diseases in the Fetal Alcohol Spectrum Disorder family:

fetal alcohol syndrome

Diseases related to Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1partial fetal alcohol syndrome31.3ACER3, PFAS
2substance abuse30.7ADH1B, ALDH2
3fetal alcohol spectrum disorder30.7PFAS, PVALB, AKR1A1, ACSS3, ADH1B
4neuronitis10.4
5hirschsprung's disease10.4VIP
6alcohol abuse10.3ALDH2, AKR1A1
7optic nerve hypoplasia10.3
8alcoholic pancreatitis10.2ALDH2, AKR1A1, ADH1B
9alcoholic liver cirrhosis10.2ALDH2, AKR1A1, ADH1B
10renal clear cell carcinoma10.2CALB2, PVALB
11pancreatitis, chronic10.2ADH1B, ALDH2, AKR1A1
12multiple system atrophy10.2GFAP, PVALB
13liver cirrhosis10.2AKR1A1, ADH1B, ALDH2
14alcohol-related neurodevelopmental disorder10.2
15memory impairment10.2
16alcohol dependence10.2ADH1A, ALDH2, ADH1B
17viral hepatitis10.2ADH1B, AKR1A1
18adrenocortical carcinoma10.2VIP, CALB2
19ganglioneuroma10.2GFAP, VIP
20esophageal cancer10.2ALDH2, ADH1B
21galactosemia10.2ALDH2, ADH1B, AKR1A1
22temporal lobe epilepsy10.1GFAP, PVALB
23ganglioglioma10.1GFAP, PVALB, CALB2
24prion disease10.1CALB2, GFAP, PVALB
25amyotrophic lateral sclerosis type 1410.1PVALB, GFAP, CALB2
26dementia10.1ALDH2, GFAP, PVALB
27parkinson's disease10.0AKR1A1, PVALB, CALB2, ALDH2
28attention deficit hyperactivity disorder10.0
29burns10.0
30keratoconus10.0
31neural tube defects10.0
32phenylketonuria10.0
33schizophrenia10.0
34fragile x syndrome10.0
35down syndrome10.0
36rett syndrome10.0
37cleft palate10.0
38cleft lip10.0
39prader-willi syndrome10.0
40sudden infant death syndrome10.0
41alcohol-related birth defect10.0
42microcephaly10.0
43cerebritis10.0
44digeorge syndrome10.0
45adrenal carcinoma10.0
46ischemia10.0
47learning disability10.0
48pyloric stenosis10.0
49retinoschisis10.0
50synostosis10.0

Graphical network of the top 20 diseases related to Fetal Alcohol Syndrome:



Diseases related to fetal alcohol syndrome

Symptoms for Fetal Alcohol Syndrome

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Drugs & Therapeutics for Fetal Alcohol Syndrome

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Drug clinical trials:

Search ClinicalTrials for Fetal Alcohol Syndrome

Search NIH Clinical Center for Fetal Alcohol Syndrome

Genetic Tests for Fetal Alcohol Syndrome

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Anatomical Context for Fetal Alcohol Syndrome

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MalaCards organs/tissues related to Fetal Alcohol Syndrome:

32
Eye, Brain, Testes, Liver, Bone, Thymus, Heart, Endothelial

Animal Models for Fetal Alcohol Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Fetal Alcohol Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.9ALDH2, CALB2, PVALB, CHRM3, VIP, GFAP

Publications for Fetal Alcohol Syndrome

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Articles related to Fetal Alcohol Syndrome:

(show top 50)    (show all 509)
idTitleAuthorsYear
1
Fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorder (FASD)-diagnosis and moral policing; an ethical dilemma for paediatricians. (25005521)
2014
2
A potential molecular target for morphological defects of fetal alcohol syndrome: Kir2.1. (23756044)
2013
3
Health care burden and cost associated with fetal alcohol syndrome: based on official Canadian data. (22900084)
2012
4
Teaching NeuroImages: Schizencephaly in fetal alcohol syndrome. (22025464)
2011
5
Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice. (21383198)
2011
6
Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate. (20451895)
2010
7
Fetal alcohol syndrome and fetal alcohol spectrum disorder in Indigenous schoolchildren. (19296803)
2009
8
Maternal risk factors for fetal alcohol syndrome and partial fetal alcohol syndrome in South Africa: a third study. (18336634)
2008
9
Automated diagnosis of fetal alcohol syndrome using 3D facial image analysis. (18713153)
2008
10
Identification of transcription factor and microRNA binding sites in responsible to fetal alcohol syndrome. (18366608)
2008
11
Impaired eyeblink conditioning in children with fetal alcohol syndrome. (18162064)
2008
12
Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome. (17200951)
2007
13
Stereo image matching for facial feature measurement to aid in fetal alcohol syndrome screening. (16904364)
2007
14
Ethanol impairs Rho GTPase signaling and differentiation of cerebellar granule neurons in a rodent model of fetal alcohol syndrome. (17109064)
2006
15
Using the past to step forward: fetal alcohol syndrome in the Western Cape Province of South Africa. (15983266)
2005
16
Fetal alcohol syndrome. Introduction. (15223535)
2004
17
Increased sibling mortality in children with fetal alcohol syndrome. (15223547)
2004
18
A comparison of fetal alcohol syndrome surveillance network and birth defects surveillance methodology in determining prevalence rates of fetal alcohol syndrome. (14703793)
2003
19
Recognition and management of fetal alcohol syndrome. (14624967)
2003
20
From the Centers for Disease Control and Prevention. Fetal alcohol syndrome--Alaska, Arizona, Colorado, and New York, 1995-1997. (12099269)
2002
21
Fetal alcohol syndrome. (20046289)
2002
22
Fetal alcohol syndrome: What you should know about drinking during pregnancy. (20046290)
2002
23
Application of the fetal alcohol syndrome facial photographic screening tool in a foster care population. (12410204)
2002
24
Midaortic syndrome associated with fetal alcohol syndrome. (12427818)
2002
25
Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome. (11303069)
2001
26
Gin Lane: did Hogarth know about fetal alcohol syndrome? (11259209)
2001
27
Physician awareness and screening for fetal alcohol syndrome. (11010122)
2000
28
Fetal alcohol syndrome in SALo Paulo, Brazil. (10563369)
1999
29
Neuropsychological comparison of alcohol-exposed children with or without physical features of fetal alcohol syndrome. (9460742)
1998
30
Bone age and growth in fetal alcohol syndrome. (9756047)
1998
31
Contribution to first-pass metabolism of ethanol and inhibition by ethanol for retinol oxidation in human alcohol dehydrogenase family--implications for etiology of fetal alcohol syndrome and alcohol-related diseases. (9652389)
1998
32
Fetal alcohol syndrome update. (9323398)
1997
33
Fetal alcohol syndrome epidemic on Manitoba reserve. (9220946)
1997
34
Fetal alcohol syndrome. (9113456)
1997
35
Variation in induction of human placental CYP2E1: possible role in susceptibility to fetal alcohol syndrome? (9194424)
1997
36
Optic nerve hypoplasia in fetal alcohol syndrome: an update. (9352281)
1997
37
Ethanol inhibition of retinoic acid synthesis as a potential mechanism for fetal alcohol syndrome. (8801166)
1996
38
A multiple-level, comprehensive approach to the prevention of fetal alcohol syndrome (FAS) and other alcohol-related birth defects (ARBD). (8557409)
1995
39
Neonatal diagnosis of fetal alcohol syndrome: not necessarily a hopeless prognosis. (8749826)
1995
40
Epidemiology of fetal alcohol syndrome in American Indians, Alaskan Natives, and Canadian Aboriginal peoples: a review of the literature. (7938391)
1994
41
Fetal alcohol syndrome: review of the literature with implications for physical therapists. (7689232)
1993
42
Fetal alcohol syndrome--United States, 1979-1992. (8479418)
1993
43
Corneal endothelial anomalies in the fetal alcohol syndrome. (1497528)
1992
44
Fetal alcohol syndrome: a case report of neuropsychological, MRI and EEG assessment of two children. (1443415)
1992
45
Fetal alcohol syndrome: misplaced emphasis. (2058598)
1991
46
Fetal alcohol syndrome in adolescents and adults. (2008025)
1991
47
Fetal alcohol syndrome: a description of oral motor, articulatory, short-term memory, grammatical, and semantic abilities. (2341602)
1990
48
Neuropsychological deficits in fetal alcohol syndrome and fetal alcohol effects. (2264592)
1990
49
Fetal alcohol syndrome: report of one case. (2260467)
1990
50
Fetal alcohol syndrome. (3048231)
1988

Variations for Fetal Alcohol Syndrome

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Expression for genes affiliated with Fetal Alcohol Syndrome

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Expression patterns in normal tissues for genes affiliated with Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Fetal Alcohol Syndrome.

Pathways for genes affiliated with Fetal Alcohol Syndrome

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Pathways related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8AKR1A1, ALDH2
29.6ADH1A, ADH1B
3
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)37
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA37
tryptophan degradation37
glutaryl-CoA degradation37
serotonin degradation37
NAD de novo biosynthesis37
superpathway of melatonin degradation37
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde37
tryptophan utilization I37
melatonin degradation I37
9.5ALDH2, AKR1A1, ADH1B
4
Show member pathways
acetate conversion to acetyl-CoA37
oxidative ethanol degradation III37
ethanol degradation IV37
9.4ADH1B, ALDH2, ACSS3
5
Show member pathways
9.3ALDH2, ADH1A, ADH1B
6
Show member pathways
mitochondrial L-carnitine shuttle pathway37
Saturated fatty acid biosynthesis60
9.3ADH1A, ADH1B, ALDH2
7
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
9.3ADH1A, ALDH2, ADH1B
8
Show member pathways
8.9AKR1A1, ADH1B, ADH1A, ALDH2
9
Show member pathways
8.9ADH1A, ADH1B, AKR1A1, ALDH2
10
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
8.9ADH1A, ADH1B, ALDH2, AKR1A1
11
Show member pathways
7.2ACER3, CHRM3, ACSS3, PFAS, AKR1A1, ALDH2

Compounds for genes affiliated with Fetal Alcohol Syndrome

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Compounds related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1n-benzylformamide44 1111.2ADH1B, AKR1A1
2propionaldehyde4410.1AKR1A1, ALDH2
3benzaldehyde44 2411.1ALDH2, AKR1A1
4glyceraldehyde44 2411.0AKR1A1, ALDH2
5rsai449.9AKR1A1, ALDH2, ADH1B
63,4-Dihydroxyphenylglycol249.9ADH1A, ADH1B
78-bromo-cyclic amp449.9VIP, GFAP
89-cis-Retinal249.8ADH1A, ADH1B
9guanylate449.8PFAS, ALDH2, VIP
10Retinal249.8ADH1B, ADH1A
11tetrodotoxin44 61 2811.7VIP, PVALB, GFAP
12betaine aldehyde44 2410.7ADH1B, ADH1A, ALDH2
133a,7a-Dihydroxy-5b-cholestan-26-al249.7ALDH2, ADH1B, ADH1A
143,4-Dihydroxymandelaldehyde249.7ADH1A, ADH1B
15nad+449.6AKR1A1, ALDH2, PVALB
161-Pentanol249.6ADH1B, AKR1A1, ADH1A
17haloperidol44 50 28 2 1113.6PVALB, VIP, AKR1A1
18Isopropyl alcohol249.6ADH1A, ADH1B, AKR1A1
191-Hexanol249.6ADH1A, AKR1A1, ADH1B
20Isobutanol249.6ADH1A, ADH1B, AKR1A1
21Propyl alcohol249.6AKR1A1, ADH1B, ADH1A
22cyanine449.6PVALB, CALB2
231-Butanol249.6ADH1B, AKR1A1, ADH1A
24verapamil44 28 50 24 1113.4AKR1A1, VIP, GFAP
25formaldehyde44 2410.4PVALB, GFAP, AKR1A1, ALDH2
26glutamine449.4ALDH2, AKR1A1, VIP, GFAP
27histamine44 28 2411.4ALDH2, VIP, AKR1A1, PVALB
28acetaldehyde28 44 2411.3ALDH2, AKR1A1, ADH1B, ADH1A
29quinolinic acid44 2410.3GFAP, CALB2, PVALB
30NADP249.3ALDH2, AKR1A1, ADH1A, ADH1B
31vitamin a44 24 1111.3AKR1A1, ADH1B, ADH1A, ALDH2
32nad28 2410.2ALDH2, AKR1A1, ADH1A, ADH1B
33nadh44 24 1111.2ADH1A, AKR1A1, ALDH2, ADH1B
34silver449.2CALB2, GFAP, PVALB
35polyacrylamide449.2ALDH2, PVALB, AKR1A1, ADH1B, GFAP
36carbachol44 28 1111.2KCNJ2, VIP, CHRM3
37arginine449.1AKR1A1, ALDH2, VIP, GFAP, KCNJ2
385-hydroxytryptamine449.0CALB2, AKR1A1, VIP, GFAP
39aspartate448.8VIP, AKR1A1, ALDH2, PVALB, GFAP, CHRM3
40cysteine448.7AKR1A1, CHRM3, ALDH2, GFAP, VIP
41acetylcholine44 50 28 24 1112.7GFAP, CALB2, PVALB, CHRM3, VIP
42gaba448.6PVALB, AKR1A1, VIP, CALB2, GFAP
43estrogen448.3AKR1A1, VIP, PVALB, GFAP, CALB2
44glutamate448.3AKR1A1, ALDH2, GFAP, VIP, PVALB, CALB2
45dopamine44 28 24 1111.1AKR1A1, GFAP, CALB2, ALDH2, PVALB, VIP
46nadph44 249.1ADH1A, CALB2, ADH1B, AKR1A1, PVALB, ALDH2
47zinc44 249.0ADH1B, PVALB, AKR1A1, GFAP, ADH1A, CALB2
48tyrosine447.9VIP, GFAP, KCNJ2, CALB2, CHRM3, PVALB
49choline44 24 119.8GFAP, CALB2, ADH1B, PVALB, CHRM3, VIP
50ethanol44 50 24 1110.4PVALB, CHRM3, ADH1B, ADH1A, GFAP, CALB2

GO Terms for genes affiliated with Fetal Alcohol Syndrome

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Biological processes related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alcohol metabolic processGO:0060669.6ALDH2, ADH1A
2ethanol oxidationGO:0060699.4ALDH2, ADH1B, ADH1A
3cytosolic calcium ion homeostasisGO:0514809.2CALB2, PVALB
4xenobiotic metabolic processGO:0068059.0ADH1A, ADH1B, ALDH2
5small molecule metabolic processGO:0442818.1PFAS, ADH1A, ADH1B, CHRM3, ACER3, ALDH2

Molecular functions related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alcohol dehydrogenase activity, zinc-dependentGO:0040249.6ADH1B, ADH1A

Products for genes affiliated with Fetal Alcohol Syndrome

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Sources for Fetal Alcohol Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet