MCID: FTL001
MIFTS: 44

Fetal Alcohol Syndrome malady

Summaries for Fetal Alcohol Syndrome

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. the presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.

MalaCards: Fetal Alcohol Syndrome is related to fetal alcohol spectrum disorder and partial fetal alcohol syndrome. An important gene associated with Fetal Alcohol Syndrome is PFAS (phosphoribosylformylglycinamidine synthase), and among its related pathways are ethanol degradation II and Abacavir Pathway, Pharmacokinetics/Pharmacodynamics. The compounds win 18446 and alda 1 have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotypes are craniofacial and vision/eye.

Aliases & Classifications for Fetal Alcohol Syndrome

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8Disease Ontology, 60UMLS
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Aliases & Descriptions:

fetal alcohol syndrome 8 60


External Ids:

Disease Ontology8 DOID:0050665

Related Diseases for Fetal Alcohol Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Fetal Alcohol Spectrum Disorder family:

fetal alcohol syndrome

Diseases related to Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1fetal alcohol spectrum disorder30.9AKR1A1, ADH1B, PFAS, PVALB
2partial fetal alcohol syndrome30.7ACER3, PFAS
3alcohol-related neurodevelopmental disorder30.2PFAS
4alcohol dependence30.2ADH1B, ADH6, ALDH2, ADH1A
5adult syndrome10.5
6image syndrome10.4
7neuronitis10.3
8speech disorder10.2
9alcohol abuse10.1
10cleft palate10.1
11down syndrome10.1
12substance abuse10.1
13attention deficit hyperactivity disorder10.0
14burns10.0
15rett syndrome10.0
16cerebritis10.0
17digeorge syndrome10.0
18sudden infant death syndrome10.0
19west syndrome10.0
20arts syndrome10.0
21microcephaly10.0
22cleft lip10.0
23phenylketonuria10.0
24prader-willi syndrome10.0
25klippel-feil syndrome10.0
26alcohol-related birth defect10.0
27fragile x syndrome10.0
28adrenal carcinoma10.0
29ischemia10.0
30keratoconus10.0
31learning disability10.0
32pyloric stenosis10.0
33retinoschisis10.0
34synostosis10.0
35polymicrogyria10.0
36malignant pleural mesothelioma10.0CALB2
37myocardial infarction10.0ALDH2, AKR1A1
38alcoholic pancreatitis10.0AKR1A1, ADH1B, ALDH2
39alcoholic liver cirrhosis10.0ADH1B, AKR1A1, ALDH2
40pancreatic cancer10.0VIP
41tuberculosis10.0AKR1A1
42pancreatitis, chronic10.0ADH1B, ALDH2, AKR1A1
43liver cirrhosis10.0VIP, AKR1A1, ALDH2, ADH1B
44parkinson's disease10.0PVALB, AKR1A1, ALDH2, CALB2
45squamous cell carcinoma10.0ALDH2, AKR1A1, RBP1, CALB2, ADH1B

Graphical network of the top 20 diseases related to Fetal Alcohol Syndrome:



Diseases related to fetal alcohol syndrome

Clinical Features for Fetal Alcohol Syndrome

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Drugs & Therapeutics for Fetal Alcohol Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Fetal Alcohol Syndrome

Drug clinical trials:

Search ClinicalTrials for Fetal Alcohol Syndrome

Search NIH Clinical Center for Fetal Alcohol Syndrome

Search CenterWatch for Fetal Alcohol Syndrome

Genetic Tests for Fetal Alcohol Syndrome

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Anatomical Context for Fetal Alcohol Syndrome

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Sources:
32MalaCards
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MalaCards organs/tissues related to Fetal Alcohol Syndrome:

32
Eye, Brain, Testes, Liver, Bone, Thymus, Heart, Endothelial

Animal Models for Fetal Alcohol Syndrome or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Fetal Alcohol Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.4ZIC5, AKR1A1, NKD2, PFAS, DVL3, OTX2
2MP:00053919.4RBP1, PFAS, OTX2, ALDH2, ALDH1A2, ZIC5
3MP:00053909.2ZIC5, AKR1A1, NKD2, PFAS, DVL3, OTX2
4MP:00053898.8ALDH2, VIP, DIO3, DMBX1, RBP1, AKR1A1
5MP:00053868.7VIP, PVALB, ZIC5, CALB2, DMBX1, NKD2
6MP:00053788.6RBP1, DMBX1, DIO3, ZIC5, NKD2, DVL3
7MP:00036318.6PVALB, ZIC5, CALB2, DMBX1, RBP1, DVL3
8MP:00053768.5VIP, DIO3, DMBX1, RBP1, AKR1A1, DVL3
9MP:00107688.4DMBX1, DIO3, ZIC5, VIP, AKR1A1, DVL3

Publications for Fetal Alcohol Syndrome

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Sources:
50PubMed
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Articles related to Fetal Alcohol Syndrome:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Ophthalmologic findings in Russian children with fetal alcohol syndrome. (23661538)
2013
2
The first description of fetal alcohol syndrome by French pediatrician Paul Lemoine. (22684432)
2012
3
Altered adult hippocampal neuronal maturation in a rat model of fetal alcohol syndrome. (21303667)
2011
4
Goal-directed arm movements in children with fetal alcohol syndrome: a kinematic approach. (20629717)
2011
5
Impaired delay and trace eyeblink conditioning in school-age children with fetal alcohol syndrome. (21073484)
2011
6
Cortical thickness in fetal alcohol syndrome and attention deficit disorder. (22115001)
2011
7
A review of facial image analysis for delineation of the facial phenotype associated with fetal alcohol syndrome. (20101703)
2010
8
Fetal alcohol syndrome: knowledge and attitudes of family medicine clerkship and residency directors. (20056372)
2010
9
A better future for baby: stemming the tide of fetal alcohol syndrome. (20544066)
2010
10
Prevention is best for fetal alcohol syndrome. (19159836)
2009
11
Design, construction, and testing of a stereo-photogrammetric tool for the diagnosis of fetal alcohol syndrome in infants. (19336298)
2009
12
Fetal alcohol syndrome disorder pilot media intervention in New Jersey. (18299640)
2008
13
Metabolic and genetic factors contributing to alcohol induced effects and fetal alcohol syndrome. (16908065)
2007
14
Computational selection and prioritization of candidate genes for fetal alcohol syndrome. (17961254)
2007
15
The International society for developmental psychobiology 39th annual meeting symposium: Alcohol and development: beyond fetal alcohol syndrome. (17380525)
2007
16
Issues in estimating the prevalence of fetal alcohol syndrome: examination of 2 counties in New York State. (17272600)
2007
17
Fetal alcohol syndrome: an assessment of the field. (15956764)
2005
18
Fetal alcohol syndrome. Introduction. (15223535)
2004
19
The Wisconsin Fetal Alcohol Syndrome Screening Project. (15553566)
2004
20
Fetal alcohol syndrome in the United States corrections system. (15223545)
2004
21
Report from the CDC. Physician and allied health professionals' training and fetal alcohol syndrome. (15072726)
2004
22
Fetal alcohol syndrome. (15135617)
2004
23
Fetal alcohol syndrome: a growing concern for health care professionals. (12685673)
2003
24
Diagnosis of FAS: a comparison of the Fetal Alcohol Syndrome Diagnostic Checklist and the Institute of Medicine Criteria for Fetal Alcohol Syndrome. (14624971)
2003
25
Assessing the risk of fetal alcohol syndrome: understanding substance use among pregnant women. (14624965)
2003
26
A multiple source methodology for the surveillance of fetal alcohol syndrome--The Fetal Alcohol Syndrome Surveillance Network (FASSNet). (12239744)
2002
27
Fetal alcohol syndrome: an international perspective. (11391072)
2001
28
Fetal alcohol syndrome (FAS) primary prevention through FAS diagnosis: I. Identification of high-risk birth mothers through the diagnosis of their children. (11022025)
2000
29
Vanished twin and fetal alcohol syndrome in the surviving twin. A case report. (10319316)
1999
30
The FAS Screen: a rapid screening tool for fetal alcohol syndrome. (20575800)
1999
31
What do physicians know and say about fetal alcohol syndrome: a survey of obstetricians, pediatricians, and family medicine physicians. (9884137)
1998
32
Fetal alcohol syndrome--recognition and intervention. (9631626)
1997
33
Ethanol inhibition of retinoic acid synthesis as a potential mechanism for fetal alcohol syndrome. (8801166)
1996
34
The fetal alcohol syndrome and fetal alcohol effects on immune competence. (7662046)
1995
35
Ethanol effects on embryonic craniofacial growth and development: implications for study of the fetal alcohol syndrome. (8198217)
1994
36
Fetal alcohol syndrome: the vulnerability of the developing brain and possible mechanisms of damage. (7898398)
1994
37
From the Centers for Disease Control an Prevention. Alcohol consumption and fetal alcohol syndrome awareness--Alaska, 1991 and 1993. (8295302)
1994
38
Prevalence and characteristics of alcohol consumption and fetal alcohol syndrome awareness--Alaska, 1991 and 1993. (8272048)
1994
39
Fetal alcohol syndrome. (11652135)
1993
40
Diffuse corneal clouding in siblings with fetal alcohol syndrome. (8470721)
1993
41
Fetal alcohol syndrome and bilateral tibial exostoses. A case report. (8152879)
1993
42
Corneal endothelial anomalies in the fetal alcohol syndrome. (1497528)
1992
43
Fetal alcohol syndrome: a case report of neuropsychological, MRI and EEG assessment of two children. (1443415)
1992
44
Organization battles fetal alcohol syndrome. (1435845)
1992
45
Recognition and prevention of fetal alcohol syndrome. (1609558)
1992
46
Fetal alcohol syndrome in adolescents and adults. (2008025)
1991
47
Clinical correlations between ethanol intake and fetal alcohol syndrome. (1758980)
1991
48
A test-retest study of intelligence in patients with fetal alcohol syndrome: implications for care. (1823538)
1991
49
Fetal alcohol syndrome: report of one case. (2260467)
1990
50
The metabolic basis of the fetal alcohol syndrome. (1981207)
1990

Genetic Variations for Fetal Alcohol Syndrome

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Expression for genes affiliated with Fetal Alcohol Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Fetal Alcohol Syndrome.

Pathways for genes affiliated with Fetal Alcohol Syndrome

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 4Cell Signaling Technology, 29KEGG, 53Reactome, 12EMD Millipore
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Pathways related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ADH1B, ALDH2
210.1ADH1B, ADH1A
3
Hide members
10.1ADH1A, ADH1B
4
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10.0ALDH2, ADH1B, ADH6
59.9OTX2, DVL3, NKD2
69.9ZIC5, DMBX1, DVL3
7
Hide members
9.9ADH1A, ADH1B, ADH6
89.7ADH1A, ALDH1A2, RBP1
9
Hide members
9.7ADH6, ADH1B, ALDH2, AKR1A1
10
Hide members
9.7ADH6, ADH1B, ADH1A, ALDH1A2
11
Hide members
9.7ADH6, ADH1B, ADH1A, ALDH2
12
Hide members
9.7ALDH2, ADH1A, ADH1B, ADH6
13
Hide members
9.5ADH6, ADH1B, ADH1A, ALDH2, AKR1A1
14
Hide members
9.5ADH6, ADH1B, ADH1A, ALDH2, AKR1A1
15
Hide members
9.5AKR1A1, ALDH2, ADH1A, ADH1B, ADH6
16
Hide members
9.3ACER3, ALDH2, ALDH1A2, ADH1A, ADH1B, ADH6

Compounds for genes affiliated with Fetal Alcohol Syndrome

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Sources:
59Tocris Bioscience, 44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1win 184465910.5ALDH2, ALDH1A2
2alda 15910.5ALDH2, ALDH1A2
3n-benzylformamide44 1111.5AKR1A1, ADH1B
4decanal44 2411.4ALDH2, ALDH1A2
54-Iodopyrazole1110.4ADH1A, ADH1B
6propionaldehyde4410.3AKR1A1, ALDH2
7Fomepizole1110.3ADH1B, ADH1A
8cyanine4410.3PVALB, CALB2
9benzaldehyde44 2411.3ALDH2, AKR1A1
10rsai4410.3ADH1B, ALDH2, AKR1A1
11glyceraldehyde44 2411.3ALDH2, AKR1A1
12retinaldehyde4410.2ALDH1A2, ALDH2, RBP1
13abacavir44 49 1112.2ADH6, AKR1A1
14betaine aldehyde44 2411.1ALDH2, ADH1A, ADH1B, ADH6
15guanylate4410.0VIP, PFAS, ALDH2
16benzyl alcohol44 1111.0ALDH2, AKR1A1
17haloperidol44 28 2 49 1114.0VIP, PVALB, AKR1A1
18polyacrylamide4410.0ADH1B, ALDH2, AKR1A1, PVALB
19glycerol44 11 2411.9AKR1A1, ADH1A, ADH1B, ADH6
20nad+449.9ALDH2, AKR1A1, RBP1, PVALB
21Nicotinamide-Adenine-Dinucleotide119.9AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B
22gaba449.8VIP, PVALB, CALB2, AKR1A1
235-hydroxytryptamine449.8AKR1A1, CALB2, VIP
24hydride449.8ALDH2, AKR1A1
25histamine44 28 2411.8ALDH2, AKR1A1, PVALB, VIP
26acetaldehyde44 28 2411.7ADH6, AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B
27retinoid449.7RBP1, AKR1A1, ALDH2, ALDH1A2, ADH1A
28nad28 2410.7AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B, ADH6
29nadh44 11 2411.7AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B, ADH6
30dopamine44 28 11 2412.6VIP, PVALB, CALB2, AKR1A1, ALDH2, ADH1B
31choline44 11 2411.6VIP, PVALB, CALB2, ADH1A, ADH1B, ADH6
32zinc44 2410.4PVALB, CALB2, AKR1A1, ADH1A, ADH1B, ADH6
33vitamin a44 11 2411.4RBP1, AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B
34ethanol44 49 11 2412.1PVALB, CALB2, RBP1, AKR1A1, ALDH2, ADH1A
35nadph44 2410.1PVALB, CALB2, RBP1, AKR1A1, ALDH2, ADH1A

GO Terms for genes affiliated with Fetal Alcohol Syndrome

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16Gene Ontology
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Biological processes related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hindbrain developmentGO:03090210.2ALDH1A2, EN2
2vitamin A metabolic processGO:00677610.0RBP1, ALDH1A2
3alcohol metabolic processGO:0060669.9ALDH2, ADH1A
4ethanol oxidationGO:0060699.8ADH6, ADH1B, ADH1A, ALDH2
5xenobiotic metabolic processGO:0068059.8ALDH2, ADH1A, ADH1B, ADH6
6small molecule metabolic processGO:0442818.8DIO3, PFAS, ACER3, ALDH2, ADH1A, ADH1B

Molecular functions related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinal bindingGO:01691810.0ALDH1A2, RBP1
2alcohol dehydrogenase activity, zinc-dependentGO:00402410.0ADH1B, ADH1A
3alcohol dehydrogenase (NAD) activityGO:0040229.7ADH6, ADH1A

Products for genes affiliated with Fetal Alcohol Syndrome

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Sources for Fetal Alcohol Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet