MCID: FTL001
MIFTS: 44

Fetal Alcohol Syndrome malady

Summaries for Fetal Alcohol Syndrome

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. the presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.

MalaCards: Fetal Alcohol Syndrome is related to fetal alcohol spectrum disorder and partial fetal alcohol syndrome. An important gene associated with Fetal Alcohol Syndrome is PFAS (phosphoribosylformylglycinamidine synthase), and among its related pathways are ethanol degradation II and Abacavir Pathway, Pharmacokinetics/Pharmacodynamics. The compounds alda 1 and win 18446 have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotypes are craniofacial and vision/eye.

Aliases & Classifications for Fetal Alcohol Syndrome

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8Disease Ontology, 60UMLS
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Aliases & Descriptions:

fetal alcohol syndrome 8 60


External Ids:

Disease Ontology8 DOID:0050665

Related Diseases for Fetal Alcohol Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Fetal Alcohol Spectrum Disorder family:

fetal alcohol syndrome

Diseases related to Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1fetal alcohol spectrum disorder30.9AKR1A1, ADH1B, PFAS, PVALB
2partial fetal alcohol syndrome30.7ACER3, PFAS
3alcohol-related neurodevelopmental disorder30.2PFAS
4alcohol dependence30.2ADH1B, ADH6, ALDH2, ADH1A
5adult syndrome10.5
6image syndrome10.4
7neuronitis10.3
8speech disorder10.2
9alcohol abuse10.1
10cleft palate10.1
11down syndrome10.1
12substance abuse10.1
13attention deficit hyperactivity disorder10.0
14burns10.0
15rett syndrome10.0
16cerebritis10.0
17digeorge syndrome10.0
18sudden infant death syndrome10.0
19west syndrome10.0
20arts syndrome10.0
21microcephaly10.0
22cleft lip10.0
23phenylketonuria10.0
24prader-willi syndrome10.0
25klippel-feil syndrome10.0
26alcohol-related birth defect10.0
27fragile x syndrome10.0
28adrenal carcinoma10.0
29ischemia10.0
30keratoconus10.0
31learning disability10.0
32pyloric stenosis10.0
33retinoschisis10.0
34synostosis10.0
35polymicrogyria10.0
36malignant pleural mesothelioma10.0CALB2
37myocardial infarction10.0ALDH2, AKR1A1
38alcoholic pancreatitis10.0AKR1A1, ADH1B, ALDH2
39alcoholic liver cirrhosis10.0ADH1B, AKR1A1, ALDH2
40pancreatic cancer10.0VIP
41tuberculosis10.0AKR1A1
42pancreatitis, chronic10.0ADH1B, ALDH2, AKR1A1
43liver cirrhosis10.0VIP, AKR1A1, ALDH2, ADH1B
44parkinson's disease10.0PVALB, AKR1A1, ALDH2, CALB2
45squamous cell carcinoma10.0ALDH2, AKR1A1, RBP1, CALB2, ADH1B

Graphical network of the top 20 diseases related to Fetal Alcohol Syndrome:



Diseases related to fetal alcohol syndrome

Clinical Features for Fetal Alcohol Syndrome

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Drugs & Therapeutics for Fetal Alcohol Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Fetal Alcohol Syndrome

Drug clinical trials:

Search ClinicalTrials for Fetal Alcohol Syndrome

Search NIH Clinical Center for Fetal Alcohol Syndrome

Search CenterWatch for Fetal Alcohol Syndrome

Genetic Tests for Fetal Alcohol Syndrome

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Anatomical Context for Fetal Alcohol Syndrome

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32MalaCards
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MalaCards organs/tissues related to Fetal Alcohol Syndrome:

32
Eye, Brain, Testes, Liver, Bone, Thymus, Heart, Endothelial

Animal Models for Fetal Alcohol Syndrome or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Fetal Alcohol Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.4ZIC5, AKR1A1, NKD2, PFAS, DVL3, OTX2
2MP:00053919.4RBP1, PFAS, OTX2, ALDH2, ALDH1A2, ZIC5
3MP:00053909.2AKR1A1, NKD2, ZIC5, ALDH1A2, PFAS, DVL3
4MP:00053898.8DMBX1, VIP, DIO3, AKR1A1, NKD2, OTX2
5MP:00053868.7VIP, ALDH2, EN2, OTX2, NKD2, DMBX1
6MP:00053788.6EN2, ALDH1A2, NKD2, ZIC5, DIO3, DMBX1
7MP:00036318.6ZIC5, CALB2, DMBX1, RBP1, OTX2, EN2
8MP:00053768.5RBP1, VIP, DIO3, DMBX1, AKR1A1, DVL3
9MP:00107688.4ALDH1A2, ALDH2, EN2, AKR1A1, OTX2, DVL3

Publications for Fetal Alcohol Syndrome

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Sources:
50PubMed
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Articles related to Fetal Alcohol Syndrome:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Teaching NeuroImages: Schizencephaly in fetal alcohol syndrome. (22025464)
2011
2
Evaluation of a service provider short course for prevention of fetal alcohol syndrome. (21683034)
2011
3
Reversal of alcohol-induced learning deficits in the young adult in a model of fetal alcohol syndrome. (20093910)
2010
4
Diagnosis of fetal alcohol spectrum disorders: a validity study of the fetal alcohol syndrome checklist. (20053521)
2010
5
Screening, diagnosing and prevention of fetal alcohol syndrome: is this syndrome treatable? (20551645)
2010
6
Eye abnormalities in fetal alcohol syndrome. (19907681)
2009
7
Maternal risk factors for fetal alcohol syndrome and partial fetal alcohol syndrome in South Africa: a third study. (18336634)
2008
8
Impaired placentation in fetal alcohol syndrome. (18054075)
2008
9
Fetal alcohol syndrome (FAS): a not neglectable disease. (18427391)
2008
10
Fetal alcohol syndrome among grade 1 schoolchildren in Northern Cape Province: prevalence and risk factors. (19177895)
2008
11
Novel molecular targets for the prevention of fetal alcohol syndrome. (18221215)
2007
12
Fetal alcohol syndrome and the developing socio-emotional brain. (17669569)
2007
13
Educational planning for children with fetal alcohol syndrome. (16801727)
2006
14
Maternal risk factors for fetal alcohol syndrome in the Western cape province of South Africa: a population-based study. (15933241)
2005
15
Fetal alcohol syndrome: neuropsychiatric phenomics. (14624969)
2003
16
Eye feature extraction for diagnosing the facial phenotype associated with fetal alcohol syndrome. (12572754)
2003
17
Fetal alcohol syndrome. (12795509)
2003
18
Prevention of fetal alcohol syndrome (fas). (19030531)
2003
19
A school-based screening program for fetal alcohol syndrome. (14624972)
2003
20
Differential expression of c-fos in a mouse model of fetal alcohol syndrome. (14526314)
2003
21
From recognition to responsibility: Josef Warkany, David Smith, and the fetal alcohol syndrome in the 21st century. (12749380)
2003
22
Ophthalmic involvement in the fetal alcohol syndrome: clinical and animal model studies. (11825849)
2002
23
Caring for the child with fetal alcohol syndrome. (12141072)
2002
24
Alcohol dehydrogenase-2*2 allele is associated with decreased prevalence of fetal alcohol syndrome in the mixed-ancestry population of the Western Cape Province, South Africa. (11781503)
2001
25
Psychostimulant clinical response in fetal alcohol syndrome. (10696504)
2000
26
Experimental study of umbilical cord length as a marker of fetal alcohol syndrome. (10661907)
2000
27
Unilateral retinoschisis in fetal alcohol syndrome. (11131427)
2000
28
Fetal alcohol syndrome (FAS) in dermatology: an overview and an evaluation. (10417433)
1999
29
Was the fetal alcohol syndrome recognized by the Greeks and Romans? (10659722)
1999
30
Contribution to first-pass metabolism of ethanol and inhibition by ethanol for retinol oxidation in human alcohol dehydrogenase family--implications for etiology of fetal alcohol syndrome and alcohol-related diseases. (9652389)
1998
31
Fetal alcohol syndrome: the 'American Paradox'. (9632044)
1998
32
Spatial but not object memory impairments in children with fetal alcohol syndrome. (9678226)
1998
33
Eye size in healthy Swedish children and in children with fetal alcohol syndrome. (9374253)
1997
34
Children with Fetal Alcohol Syndrome in North Dakota: a case control study utilizing birth certificate data. (12893478)
1996
35
A case definition and photographic screening tool for the facial phenotype of fetal alcohol syndrome. (8757560)
1996
36
The incidence of fetal alcohol syndrome in New Zealand. (8628531)
1996
37
Neonatal diagnosis of fetal alcohol syndrome: not necessarily a hopeless prognosis. (8749826)
1995
38
Use of capture-recapture analyses in fetal alcohol syndrome surveillance in Alaska. (7840111)
1995
39
A fetal alcohol syndrome screening tool. (8749828)
1995
40
Is moderate alcohol intake in pregnancy associated with the craniofacial features related to the fetal alcohol syndrome? (8602484)
1995
41
Stage-dependent effects of ethanol on cranial neural crest cell development: partial basis for the phenotypic variations observed in fetal alcohol syndrome. (8749810)
1995
42
Epidemiology of fetal alcohol syndrome in American Indians, Alaskan Natives, and Canadian Aboriginal peoples: a review of the literature. (7938391)
1994
43
Audiologic manifestations in fetal alcohol syndrome assessed by brainstem auditory-evoked potentials. (7885533)
1994
44
American Academy of Pediatrics Committee on Substance Abuse and Committee on Children with Disabilities: Fetal alcohol syndrome and fetal alcohol effects. (8507280)
1993
45
A fetal alcohol syndrome surveillance pilot project in American Indian communities in the Northern Plains. (8464980)
1993
46
Fetal alcohol syndrome. (17777021)
1992
47
A revised estimate of the economic impact of fetal alcohol syndrome. (1758979)
1991
48
A cephalometric assessment of children with fetal alcohol syndrome. (2705412)
1989
49
Erroneous diagnosis of fetal alcohol syndrome in a patient with ring chromosome 6. (3653144)
1987
50
The DiGeorge syndrome and the fetal alcohol syndrome. (6812410)
1982

Genetic Variations for Fetal Alcohol Syndrome

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Expression for genes affiliated with Fetal Alcohol Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Fetal Alcohol Syndrome.

Pathways for genes affiliated with Fetal Alcohol Syndrome

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 4Cell Signaling Technology, 29KEGG, 53Reactome, 12EMD Millipore
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Pathways related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ALDH2, ADH1B
210.1ADH1B, ADH1A
3
Hide members
10.1ADH1A, ADH1B
4
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10.0ALDH2, ADH1B, ADH6
59.9DVL3, OTX2, NKD2
69.9DVL3, DMBX1, ZIC5
7
Hide members
9.9ADH1A, ADH1B, ADH6
89.7ALDH1A2, ADH1A, RBP1
9
Hide members
9.7ALDH2, AKR1A1, ADH1B, ADH6
10
Hide members
9.7ADH1B, ADH6, ADH1A, ALDH1A2
11
Hide members
9.7ADH1B, ADH1A, ALDH2, ADH6
12
Hide members
9.7ADH6, ADH1B, ADH1A, ALDH2
13
Hide members
9.5ADH1B, ADH6, ADH1A, ALDH2, AKR1A1
14
Hide members
9.5ALDH2, ADH1A, ADH1B, ADH6, AKR1A1
15
Hide members
9.5ALDH2, AKR1A1, ADH1A, ADH1B, ADH6
16
Hide members
9.3ADH1A, ADH1B, ALDH1A2, ALDH2, ACER3, ADH6

Compounds for genes affiliated with Fetal Alcohol Syndrome

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Sources:
59Tocris Bioscience, 44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1alda 15910.5ALDH1A2, ALDH2
2win 184465910.5ALDH1A2, ALDH2
3n-benzylformamide44 1111.5ADH1B, AKR1A1
4decanal44 2411.5ALDH1A2, ALDH2
54-Iodopyrazole1110.4ADH1A, ADH1B
6propionaldehyde4410.3ALDH2, AKR1A1
7Fomepizole1110.3ADH1B, ADH1A
8cyanine4410.3PVALB, CALB2
9benzaldehyde44 2411.3AKR1A1, ALDH2
10rsai4410.3AKR1A1, ALDH2, ADH1B
11glyceraldehyde44 2411.3ALDH2, AKR1A1
12retinaldehyde4410.2ALDH2, RBP1, ALDH1A2
13abacavir44 49 1112.2ADH6, AKR1A1
14betaine aldehyde44 2411.1ADH1B, ALDH2, ADH6, ADH1A
15guanylate4410.0VIP, PFAS, ALDH2
16benzyl alcohol44 1111.0AKR1A1, ALDH2
17haloperidol44 28 2 49 1114.0AKR1A1, VIP, PVALB
18polyacrylamide4410.0ALDH2, AKR1A1, PVALB, ADH1B
19glycerol44 11 2411.9AKR1A1, ADH1A, ADH1B, ADH6
20nad+449.9PVALB, RBP1, AKR1A1, ALDH2
21Nicotinamide-Adenine-Dinucleotide119.9ALDH2, ADH1A, ADH1B, ALDH1A2, AKR1A1
22gaba449.8PVALB, CALB2, VIP, AKR1A1
235-hydroxytryptamine449.8CALB2, VIP, AKR1A1
24hydride449.8ALDH2, AKR1A1
25histamine44 28 2411.8ALDH2, VIP, AKR1A1, PVALB
26acetaldehyde44 28 2411.7AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B, ADH6
27retinoid449.7ADH1A, ALDH1A2, ALDH2, AKR1A1, RBP1
28nad28 2410.7ADH1B, ADH1A, ALDH1A2, AKR1A1, ADH6, ALDH2
29nadh44 11 2411.7ALDH2, ALDH1A2, ADH1A, ADH1B, ADH6, AKR1A1
30dopamine44 28 11 2412.6ADH1B, VIP, PVALB, CALB2, AKR1A1, ALDH2
31choline44 11 2411.6VIP, PVALB, ADH6, CALB2, ADH1B, ADH1A
32zinc44 2410.4ADH1B, PVALB, CALB2, AKR1A1, ADH6, ADH1A
33vitamin a44 11 2411.4AKR1A1, ADH6, ADH1B, ADH1A, ALDH1A2, ALDH2
34ethanol44 49 11 2412.1AKR1A1, ALDH2, CALB2, ADH6, ADH1B, ADH1A
35nadph44 2410.1CALB2, AKR1A1, ALDH2, ADH1A, ADH1B, ADH6

GO Terms for genes affiliated with Fetal Alcohol Syndrome

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16Gene Ontology
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Biological processes related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hindbrain developmentGO:03090210.2EN2, ALDH1A2
2alcohol metabolic processGO:00606610.0ADH1A, ALDH2
3vitamin A metabolic processGO:0067769.9RBP1, ALDH1A2
4ethanol oxidationGO:0060699.8ADH6, ADH1B, ADH1A, ALDH2
5xenobiotic metabolic processGO:0068059.8ADH1A, ALDH2, ADH1B, ADH6
6small molecule metabolic processGO:0442818.8PFAS, ACER3, ALDH2, ADH1A, ADH1B, ADH6

Molecular functions related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinal bindingGO:01691810.0ALDH1A2, RBP1
2alcohol dehydrogenase activity, zinc-dependentGO:00402410.0ADH1B, ADH1A
3alcohol dehydrogenase (NAD) activityGO:0040229.7ADH6, ADH1A

Products for genes affiliated with Fetal Alcohol Syndrome

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Sources for Fetal Alcohol Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet