MCID: FTL001
MIFTS: 44

Fetal Alcohol Syndrome malady

Summaries for Fetal Alcohol Syndrome

Sources:
8Disease Ontology, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. the presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.

MalaCards: Fetal Alcohol Syndrome is related to partial fetal alcohol syndrome and alcohol-related neurodevelopmental disorder. An important gene associated with Fetal Alcohol Syndrome is PFAS (phosphoribosylformylglycinamidine synthase), and among its related pathways are ethanol degradation II and Abacavir Pathway, Pharmacokinetics/Pharmacodynamics. The compounds win 18446 and alda 1 have been mentioned in the context of this disorder. Affiliated tissues include thymus, brain and heart, and related mouse phenotypes are craniofacial and vision/eye.

Aliases & Classifications for Fetal Alcohol Syndrome

Sources:
8Disease Ontology, 61UMLS
See all sources

Aliases & Descriptions:

fetal alcohol syndrome 8 61


External Ids:

Disease Ontology8 DOID:0050665

Related Diseases for Fetal Alcohol Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the fetal alcohol spectrum disorder family:

fetal alcohol syndrome

Diseases related to Fetal Alcohol Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1partial fetal alcohol syndrome30.9ACER3, PFAS
2alcohol-related neurodevelopmental disorder30.3PFAS
3n syndrome11.0
4char syndrome10.7
5adult syndrome10.6
6west syndrome10.5
7young syndrome10.5
8image syndrome10.4
9short syndrome10.4
10speech disorder10.3
11optic nerve hypoplasia10.3
12alcohol abuse10.2
13cleft palate10.2
14substance abuse10.2
15micro syndrome10.2
16mass syndrome10.2
17memory impairment10.2
18attention deficit hyperactivity disorder10.1
19burns10.1
20rett syndrome10.1
21digeorge syndrome10.1
22sudden infant death syndrome10.1
23microcephaly10.1
24phenylketonuria10.1
25prader-willi syndrome10.1
26klippel-feil syndrome10.1
27alcohol-related birth defect10.1
28down syndrome10.1
29adrenal carcinoma10.1
30duane retraction syndrome10.1
31synostosis10.1
323-m syndrome10.1
33polymicrogyria10.1
34wisconsin syndrome10.1
35bod syndrome10.1
36schizencephaly10.1
37german syndrome10.1
38spondylocarpotarsal synostosis syndrome10.1
39mental retardation10.1
40head injury10.1
41seizure disorder10.1
42hangover10.1
43malignant pleural mesothelioma10.0CALB2
44myocardial infarction10.0ALDH2, AKR1A1
45fetal alcohol spectrum disorder10.0AKR1A1, ADH1B, PFAS, PVALB
46alcoholic pancreatitis10.0AKR1A1, ADH1B, ALDH2
47alcoholic liver cirrhosis10.0ADH1B, AKR1A1, ALDH2
48pancreatic cancer10.0VIP
49tuberculosis10.0AKR1A1
50pancreatitis, chronic10.0ADH1B, ALDH2, AKR1A1

Graphical network of the top 20 diseases related to Fetal Alcohol Syndrome:



Diseases related to fetal alcohol syndrome

Clinical Features for Fetal Alcohol Syndrome

Drugs & Therapeutics for Fetal Alcohol Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Fetal Alcohol Syndrome

Drug clinical trials:

Search ClinicalTrials for Fetal Alcohol Syndrome

Search NIH Clinical Center for Fetal Alcohol Syndrome

Search CenterWatch for Fetal Alcohol Syndrome

Genetic Tests for Fetal Alcohol Syndrome

Anatomical Context for Fetal Alcohol Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Fetal Alcohol Syndrome:

33
Thymus, Brain, Heart, Liver, T cells, B cells, Endothelial, Fetal brain, Fetal liver

Animal Models for Fetal Alcohol Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Fetal Alcohol Syndrome

Sources:
51PubMed
See all sources

Articles related to Fetal Alcohol Syndrome:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate. (20451895)
2010
2
Characteristics of children whose siblings have fetal alcohol syndrome or incomplete fetal alcohol syndrome. (19254987)
2009
3
Fetal alcohol syndrome: historical perspectives. (17224346)
2007
4
Manic behavior resulting from left frontal closed head injury in an adult with fetal alcohol syndrome. (17878503)
2007
5
Ethanol impairs Rho GTPase signaling and differentiation of cerebellar granule neurons in a rodent model of fetal alcohol syndrome. (17109064)
2006
6
Letter and category fluency in children with fetal alcohol syndrome from a community in South Africa. (16736069)
2006
7
Comparison of motor delays in young children with fetal alcohol syndrome to those with prenatal alcohol exposure and with no prenatal alcohol exposure. (17117969)
2006
8
Deep serotonergic and dopaminergic structures in fetal alcoholic syndrome: a study with nor-beta-CIT-single-photon emission computed tomography and magnetic resonance imaging volumetry. (15953494)
2005
9
Fetal alcohol syndrome prevention in South Africa and other low-resource countries. (15961748)
2005
10
Prevention of alcohol-induced developmental delays and learning abnormalities in a model of fetal alcohol syndrome. (16157106)
2005
11
Guidelines for identifying and referring persons with fetal alcohol syndrome. (16251866)
2005
12
Fetal alcohol syndrome: diagnosis, epidemiology, and developmental outcomes. (14717994)
2004
13
Recognition and management of fetal alcohol syndrome. (14624967)
2003
14
Children with Fetal Alcohol Syndrome are impaired at place learning but not cued-navigation in a virtual Morris water task. (12842299)
2003
15
Application of the fetal alcohol syndrome facial photographic screening tool in a foster care population. (12410204)
2002
16
Statement of the Public Affairs Committee of the Teratology Society on the fetal alcohol syndrome. (12486768)
2002
17
Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome. (11303069)
2001
18
Glutamate signaling and the fetal alcohol syndrome. (11754521)
2001
19
Estimating the prevalence of fetal alcohol syndrome. A summary. (11810953)
2001
20
Fetal alcohol syndrome. (10554630)
1999
21
Vitamin E and beta-carotene protect against ethanol combined with ischemia in an embryonic rat hippocampal culture model of fetal alcohol syndrome. (10213167)
1999
22
Incidence of fetal alcohol syndrome in northeastern Manitoba. (10401171)
1999
23
Neuropsychological comparison of alcohol-exposed children with or without physical features of fetal alcohol syndrome. (9460742)
1998
24
Effectiveness of methylphenidate in Native American children with fetal alcohol syndrome and attention deficit/hyperactivity disorder: a controlled pilot study. (9639078)
1998
25
Identification of children with fetal alcohol syndrome and opportunity for referral of their mothers for primary prevention--Washington, 1993-1997. (9790662)
1998
26
Was the fetal alcohol syndrome recognized in the ancient Near East? (9131889)
1997
27
Expression of CYP2E1 during embryogenesis and fetogenesis in human cephalic tissues: implications for the fetal alcohol syndrome. (9299528)
1997
28
EEG findings in fetal alcohol syndrome and Down syndrome children. (8689990)
1996
29
Fetal alcohol syndrome: the nurse practitioner perspective. (9281978)
1996
30
Fetal alcohol syndrome--an ophthalmological and socioeducational prospective study. (8657525)
1996
31
Present state of the fetal alcohol syndrome. (8741106)
1996
32
A decrease in the size of the basal ganglia in children with fetal alcohol syndrome. (8892532)
1996
33
Increased cell death and reduced neural crest cell numbers in ethanol-exposed embryos: partial basis for the fetal alcohol syndrome phenotype. (7625573)
1995
34
Computational modeling of a putative fetal alcohol syndrome mechanism. (8749832)
1995
35
From the Centers for Disease Control and Prevention. Update: trends in fetal alcohol syndrome--United States, 1979-1993. (7723144)
1995
36
What syndrome is this? Fetal alcohol syndrome. (8041663)
1994
37
Fetal alcohol syndrome: review of the literature with implications for physical therapists. (7689232)
1993
38
The role of alcohol dehydrogenase in retinoic acid homeostasis and fetal alcohol syndrome. (7748347)
1993
39
Fetal alcohol syndrome and fetal alcohol effects. The University of Minnesota experience. (8515733)
1993
40
Prevention of fetal alcohol syndrome. (8414873)
1993
41
Dermatoglyphic asymmetry in fetal alcohol syndrome. (8399794)
1993
42
Fetal alcohol syndrome: a nursing concern. (1525500)
1992
43
Fetal alcohol syndrome: early and long-term consequences. (1435967)
1992
44
Multilevel intervention for prevention of fetal alcohol syndrome and effects of prenatal alcohol exposure. (1758982)
1991
45
Morphometry of the neonatal fetal alcohol syndrome face from 'snapshots'. (1845594)
1991
46
Factors predisposing, enabling and reinforcing routine screening of patients for preventing fetal alcohol syndrome: a survey of New Jersey physicians. (2016663)
1991
47
Appraisal of the epidemiology of fetal alcohol syndrome among Canadian native peoples. (2702544)
1989
48
A macro-level fetal alcohol syndrome prevention program for Native Americans and Alaska Natives: description and evaluation. (2586104)
1989
49
Pathological changes in peripheral nerves in experimental fetal alcohol syndrome. (2552862)
1989
50
The fetal alcohol syndrome. (3375803)
1988

Genetic Variations for Fetal Alcohol Syndrome

Expression for genes affiliated with Fetal Alcohol Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Fetal Alcohol Syndrome

Search GEO for disease gene expression data for Fetal Alcohol Syndrome.

Pathways for genes affiliated with Fetal Alcohol Syndrome

Sources:
38NCBI BioSystems Database, 50PharmGKB, 4Cell Signaling Technology, 30KEGG, 54Reactome, 12EMD Millipore
See all sources

Pathways related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ALDH2, ADH1B
210.1ADH1B, ADH1A
3
Hide members
10.1ADH1A, ADH1B
4
Hide members
10.0ALDH2, ADH1B, ADH6
59.9DVL3, OTX2, NKD2
69.9DVL3, DMBX1, ZIC5
7
Hide members
9.9ADH1A, ADH1B, ADH6
89.7ALDH1A2, ADH1A, RBP1
9
Hide members
9.7ALDH2, AKR1A1, ADH1B, ADH6
10
Hide members
9.7ADH1B, ADH6, ADH1A, ALDH1A2
11
Hide members
9.7ADH1B, ADH1A, ALDH2, ADH6
12
Hide members
9.7ADH6, ADH1B, ADH1A, ALDH2
13
Hide members
9.5ADH1B, ADH6, ADH1A, ALDH2, AKR1A1
14
Hide members
9.5ALDH2, ADH1A, ADH1B, ADH6, AKR1A1
15
Hide members
9.5ALDH2, AKR1A1, ADH1A, ADH1B, ADH6
16
Hide members
9.3ADH1A, ADH1B, ALDH1A2, ALDH2, ACER3, ADH6

Compounds for genes affiliated with Fetal Alcohol Syndrome

Sources:
60Tocris Bioscience, 45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1win 184466010.5ALDH2, ALDH1A2
2alda 16010.5ALDH2, ALDH1A2
3n-benzylformamide45 1111.5AKR1A1, ADH1B
4decanal45 2411.4ALDH2, ALDH1A2
54-Iodopyrazole1110.4ADH1A, ADH1B
6propionaldehyde4510.3AKR1A1, ALDH2
7Fomepizole1110.3ADH1B, ADH1A
8cyanine4510.3PVALB, CALB2
9benzaldehyde45 2411.3ALDH2, AKR1A1
10rsai4510.3ADH1B, ALDH2, AKR1A1
11glyceraldehyde45 2411.3ALDH2, AKR1A1
12retinaldehyde4510.2ALDH1A2, ALDH2, RBP1
13abacavir45 50 1112.2ADH6, AKR1A1
14betaine aldehyde45 2411.1ALDH2, ADH1A, ADH1B, ADH6
15guanylate4510.0VIP, PFAS, ALDH2
16benzyl alcohol45 1111.0ALDH2, AKR1A1
17haloperidol45 29 2 50 1114.0VIP, PVALB, AKR1A1
18polyacrylamide4510.0ADH1B, ALDH2, AKR1A1, PVALB
19glycerol45 11 2411.9AKR1A1, ADH1A, ADH1B, ADH6
20nad+459.9ALDH2, AKR1A1, RBP1, PVALB
21Nicotinamide-Adenine-Dinucleotide119.9AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B
22gaba459.8VIP, PVALB, CALB2, AKR1A1
235-hydroxytryptamine459.8AKR1A1, CALB2, VIP
24hydride459.8ALDH2, AKR1A1
25histamine45 29 2411.8ALDH2, AKR1A1, PVALB, VIP
26acetaldehyde45 29 2411.7ADH6, AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B
27retinoid459.7RBP1, AKR1A1, ALDH2, ALDH1A2, ADH1A
28nad29 2410.7AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B, ADH6
29nadh45 11 2411.7AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B, ADH6
30dopamine45 29 11 2412.6VIP, PVALB, CALB2, AKR1A1, ALDH2, ADH1B
31choline45 11 2411.6VIP, PVALB, CALB2, ADH1A, ADH1B, ADH6
32zinc45 2410.4PVALB, CALB2, AKR1A1, ADH1A, ADH1B, ADH6
33vitamin a45 11 2411.4RBP1, AKR1A1, ALDH2, ALDH1A2, ADH1A, ADH1B
34ethanol45 50 11 2412.1PVALB, CALB2, RBP1, AKR1A1, ALDH2, ADH1A
35nadph45 2410.1PVALB, CALB2, RBP1, AKR1A1, ALDH2, ADH1A

GO Terms for genes affiliated with Fetal Alcohol Syndrome

Sources:
16Gene Ontology
See all sources

Biological processes related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hindbrain developmentGO:03090210.2EN2, ALDH1A2
2alcohol metabolic processGO:00606610.0ADH1A, ALDH2
3vitamin A metabolic processGO:0067769.9RBP1, ALDH1A2
4ethanol oxidationGO:0060699.8ADH6, ADH1B, ADH1A, ALDH2
5xenobiotic metabolic processGO:0068059.8ADH1A, ALDH2, ADH1B, ADH6
6small molecule metabolic processGO:0442818.8PFAS, ACER3, ALDH2, ADH1A, ADH1B, ADH6

Molecular functions related to Fetal Alcohol Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinal bindingGO:01691810.0ALDH1A2, RBP1
2alcohol dehydrogenase activity, zinc-dependentGO:00402410.0ADH1B, ADH1A
3alcohol dehydrogenase (NAD) activityGO:0040229.7ADH6, ADH1A

Products for genes affiliated with Fetal Alcohol Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fetal Alcohol Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet