MCID: FTL033
MIFTS: 16

Fetal Hemoglobin Quantitative Trait Locus 1 malady

Blood category

Summaries for Fetal Hemoglobin Quantitative Trait Locus 1

Sources:
47OMIM, 33MalaCards
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MalaCards: Fetal Hemoglobin Quantitative Trait Locus 1 is related to hereditary persistence of fetal hemoglobin and hereditary persistence of fetal hemoglobin - sickle cell disease. An important gene associated with Fetal Hemoglobin Quantitative Trait Locus 1 is HBG1 (hemoglobin, gamma A), and among its related pathways are p70S6K Signaling and ErbB4 Pathway. The compounds dimethyl sulfate and benzidine have been mentioned in the context of this disorder.

Description from OMIM:47 141749

Aliases & Classifications for Fetal Hemoglobin Quantitative Trait Locus 1

Sources:
47OMIM, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

fetal hemoglobin quantitative trait locus 1 47 61


Related Diseases for Fetal Hemoglobin Quantitative Trait Locus 1

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Fetal Hemoglobin Quantitative Trait Locus 1 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary persistence of fetal hemoglobin10.4
2hereditary persistence of fetal hemoglobin - sickle cell disease10.4
3methemoglobinemia10.0HBG2
4alpha thalassemia10.0HBG1, HBB
5hemoglobinopathy10.0HBG1, HBB
6sickle cell anemia10.0HBG2, HBB
7hemolytic anemia10.0HBB, HBG2
8pre-eclampsia10.0HBG2, HBB
9acute erythroid leukemia10.0HBB, HBG1
10beta thalassemia10.0HBG2, HBB, HBG1
11sickle cell disease10.0HBG1, HBG2, HBB
12thalassemia10.0HBG1, HBG2, HBB
13deficiency anemia10.0HBG1, HBB, HBG2

Graphical network of diseases related to Fetal Hemoglobin Quantitative Trait Locus 1:



Diseases related to fetal hemoglobin quantitative trait locus 1

Clinical Features for Fetal Hemoglobin Quantitative Trait Locus 1

Sources:
47OMIM
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Clinical features from OMIM:

141749

Drugs & Therapeutics for Fetal Hemoglobin Quantitative Trait Locus 1

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Fetal Hemoglobin Quantitative Trait Locus 1

Drug clinical trials:

Search ClinicalTrials for Fetal Hemoglobin Quantitative Trait Locus 1

Search NIH Clinical Center for Fetal Hemoglobin Quantitative Trait Locus 1

Search CenterWatch for Fetal Hemoglobin Quantitative Trait Locus 1

Genetic Tests for Fetal Hemoglobin Quantitative Trait Locus 1

Anatomical Context for Fetal Hemoglobin Quantitative Trait Locus 1

Animal Models for Fetal Hemoglobin Quantitative Trait Locus 1 or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Fetal Hemoglobin Quantitative Trait Locus 1

Genetic Variations for Fetal Hemoglobin Quantitative Trait Locus 1

Expression for genes affiliated with Fetal Hemoglobin Quantitative Trait Locus 1

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fetal Hemoglobin Quantitative Trait Locus 1

Search GEO for disease gene expression data for Fetal Hemoglobin Quantitative Trait Locus 1.

Pathways for genes affiliated with Fetal Hemoglobin Quantitative Trait Locus 1

Sources:
52QIAGEN, 54Reactome
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Pathways related to Fetal Hemoglobin Quantitative Trait Locus 1 according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0HBG2, HBG1
2
Hide members
9.0HBG2, HBG1
38.5HBG2, HBB, HBG1
4
Hide members
8.5HBG1, HBB, HBG2

Compounds for genes affiliated with Fetal Hemoglobin Quantitative Trait Locus 1

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB, 29IUPHAR
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Compounds related to Fetal Hemoglobin Quantitative Trait Locus 1 according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1dimethyl sulfate459.6HBG1, HBB
2benzidine459.6HBG1, HBB
3porphobilinogen45 11 2411.6HBG1, HBB
4propionate459.6HBG1, HBB
55-aminolevulinic acid45 2410.6HBG1, HBB
6neomycin459.5HBB, HBG1
7de-oxy459.5HBB, HBG2
8s-nitrosocysteine459.5HBG2, HBB
923-diphosphoglycerate459.4HBG2, HBB
10azathioprine45 50 2 1112.4HBB, HBG1
11glyceraldehyde 3-phosphate459.3HBG1, HBB
12butyrate459.3HBG1, HBB
13glucose 6-phosphate45 2410.3HBB, HBG2
14polyacrylamide459.2HBG1, HBB
15hydroxyurea45 50 1110.8HBB, HBG2, HBG1
16histidine458.8HBB, HBG2
17heme29 11 2410.8HBG1, HBG2, HBB
18iron45 249.8HBG1, HBB, HBG2
19nitric oxide45 11 2410.7HBG2, HBB, HBG1
20oxygen45 249.6HBG2, HBG1, HBB

GO Terms for genes affiliated with Fetal Hemoglobin Quantitative Trait Locus 1

Sources:
16Gene Ontology
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Cellular components related to Fetal Hemoglobin Quantitative Trait Locus 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:0058338.5HBG2, HBB, HBG1

Biological processes related to Fetal Hemoglobin Quantitative Trait Locus 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075968.5HBG2, HBB, HBG1

Molecular functions related to Fetal Hemoglobin Quantitative Trait Locus 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen transporter activityGO:0053448.5HBG2, HBB, HBG1
2iron ion bindingGO:0055068.5HBG2, HBB, HBG1
3oxygen bindingGO:0198258.4HBG2, HBB, HBG1
4heme bindingGO:0200378.2HBG1, HBB, HBG2

Products for genes affiliated with Fetal Hemoglobin Quantitative Trait Locus 1

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fetal Hemoglobin Quantitative Trait Locus 1

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet