MCID: FTL033
MIFTS: 20

Fetal Hemoglobin Quantitative Trait Locus 1 malady

Blood diseases category

Summaries for Fetal Hemoglobin Quantitative Trait Locus 1

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46OMIM, 32MalaCards
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MalaCards: Fetal Hemoglobin Quantitative Trait Locus 1 is related to hereditary persistence of fetal hemoglobin and hereditary persistence of fetal hemoglobin - sickle cell disease. An important gene associated with Fetal Hemoglobin Quantitative Trait Locus 1 is HBG1 (hemoglobin, gamma A), and among its related pathways are p70S6K Signaling and ErbB4 Pathway. The compounds dimethyl sulfate and benzidine have been mentioned in the context of this disorder.

Description from OMIM:46 141749

Aliases & Classifications for Fetal Hemoglobin Quantitative Trait Locus 1

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46OMIM, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

fetal hemoglobin quantitative trait locus 1 46 60


Related Diseases for Fetal Hemoglobin Quantitative Trait Locus 1

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Fetal Hemoglobin Quantitative Trait Locus 1:



Diseases related to fetal hemoglobin quantitative trait locus 1

Clinical Features for Fetal Hemoglobin Quantitative Trait Locus 1

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46OMIM
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Clinical features from OMIM:

141749

Drugs & Therapeutics for Fetal Hemoglobin Quantitative Trait Locus 1

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Fetal Hemoglobin Quantitative Trait Locus 1

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Search CenterWatch for Fetal Hemoglobin Quantitative Trait Locus 1

Genetic Tests for Fetal Hemoglobin Quantitative Trait Locus 1

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Anatomical Context for Fetal Hemoglobin Quantitative Trait Locus 1

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Animal Models for Fetal Hemoglobin Quantitative Trait Locus 1 or affiliated genes

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Publications for Fetal Hemoglobin Quantitative Trait Locus 1

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Genetic Variations for Fetal Hemoglobin Quantitative Trait Locus 1

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Expression for genes affiliated with Fetal Hemoglobin Quantitative Trait Locus 1

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fetal Hemoglobin Quantitative Trait Locus 1

Search GEO for disease gene expression data for Fetal Hemoglobin Quantitative Trait Locus 1.

Pathways for genes affiliated with Fetal Hemoglobin Quantitative Trait Locus 1

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51QIAGEN, 53Reactome
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Pathways related to Fetal Hemoglobin Quantitative Trait Locus 1 according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0HBG2, HBG1
2
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9.0HBG2, HBG1
38.5HBG2, HBB, HBG1
4
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8.5HBG1, HBB, HBG2

Compounds for genes affiliated with Fetal Hemoglobin Quantitative Trait Locus 1

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 28IUPHAR
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Compounds related to Fetal Hemoglobin Quantitative Trait Locus 1 according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1dimethyl sulfate449.6HBB, HBG1
2benzidine449.6HBB, HBG1
3porphobilinogen44 11 2411.6HBG1, HBB
4propionate449.6HBG1, HBB
55-aminolevulinic acid44 2410.6HBB, HBG1
6neomycin449.5HBB, HBG1
7de-oxy449.5HBG2, HBB
8s-nitrosocysteine449.5HBB, HBG2
923-diphosphoglycerate449.4HBB, HBG2
10azathioprine44 49 2 1112.4HBB, HBG1
11glyceraldehyde 3-phosphate449.3HBB, HBG1
12butyrate449.3HBB, HBG1
13glucose 6-phosphate44 2410.3HBG2, HBB
14polyacrylamide449.2HBG1, HBB
15hydroxyurea44 49 1110.8HBG2, HBB, HBG1
16histidine448.8HBG2, HBB
17heme28 11 2410.8HBG2, HBB, HBG1
18iron44 249.8HBG2, HBB, HBG1
19nitric oxide44 11 2410.7HBG1, HBB, HBG2
20oxygen44 249.6HBG1, HBB, HBG2

GO Terms for genes affiliated with Fetal Hemoglobin Quantitative Trait Locus 1

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16Gene Ontology
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Cellular components related to Fetal Hemoglobin Quantitative Trait Locus 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:0058338.5HBG2, HBB, HBG1

Biological processes related to Fetal Hemoglobin Quantitative Trait Locus 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075968.5HBG2, HBB, HBG1

Molecular functions related to Fetal Hemoglobin Quantitative Trait Locus 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen transporter activityGO:0053448.5HBG2, HBB, HBG1
2iron ion bindingGO:0055068.5HBG1, HBB, HBG2
3oxygen bindingGO:0198258.4HBG1, HBB, HBG2
4heme bindingGO:0200378.2HBG2, HBB, HBG1

Products for genes affiliated with Fetal Hemoglobin Quantitative Trait Locus 1

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fetal Hemoglobin Quantitative Trait Locus 1

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet