MCID: FTL021
MIFTS: 44

Fetal Macrosomia malady

Rare diseases category
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Summaries for Fetal Macrosomia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Large for gestational age (LGA) is an indication of high prenatal growth rate. LGA is often defined as a... more...

MalaCards: Fetal Macrosomia is related to gestational diabetes and diabetes mellitus. An important gene associated with Fetal Macrosomia is PGM1 (phosphoglucomutase 1), and among its related pathways are HIF-1-alpha transcription factor network and AMPK signaling. The compounds poly(glu(80)tyr(20)) and chromium picolinate have been mentioned in the context of this disorder. Affiliated tissues include testes and placenta, and related mouse phenotypes are liver/biliary system and respiratory system.

Aliases & Classifications for Fetal Macrosomia

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43NIH Rare Diseases, 45Novoseek, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

fetal macrosomia 43 45 62


Related Diseases for Fetal Macrosomia

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17GeneCards, 18GeneDecks
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Diseases related to Fetal Macrosomia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1gestational diabetes30.9INS, OXT, INSR, SLC2A3, LEP
2diabetes mellitus30.6INSR, INS, IGF1, LEP, SLC2A3
3obesity30.4SLC2A3, INS, LEP, INSR, IGF1
4protein-energy malnutrition30.2IGF1, LEP
5hypoglycemia30.1IGF2, IGF1, INSR, OXT, SLC2A3, INS
6hypertension30.0IGF1, INS, LEP, INSR
7hyperinsulinism29.9INS, LEP, IGF2, INSR, IGF1
8insulin resistance29.9SLC2A3, INSR, INS, IGF2, LEP, IGF1
9vaginitis10.2
10acquired generalized lipodystrophy10.1LEP
11hemihypertrophy10.1IGF2
12polyhydramnios10.1
13hypoxia10.1
14hyperinsulinemic hypoglycemia10.1INS
15laron syndrome10.1IGF2, IGF1
16insulin-like growth factor 1 resistance to10.1IGF2, IGF1
17hypoglycemic coma10.1INS, IGF2
18familial partial lipodystrophy10.0LEP, INS
19growth retardation-mild developmental delay-chronic hepatitis syndrome10.0IGF2, IGF1
20pituitary gland disease10.0INS, IGF1
21eating disorder10.0INS, LEP
22precocious puberty10.0LEP, IGF1
23morbid obesity10.0LEP, INS
24donohue syndrome10.0INS, INSR
25uterine fibroid10.0IGF2, OXT, IGF1
26fatty liver disease10.0LEP, INS
27anorexia nervosa10.0LEP, OXT, IGF1
28cushing's syndrome10.0IGF1, LEP
29anovulation10.0INS, IGF1, LEP
30amenorrhea10.0LEP, IGF1, INS
31hypopituitarism10.0IGF1, INS, LEP
32hypogonadism10.0IGF1, LEP, INS
33galactosemia10.0IGF1, LEP, INS
34congenital heart disease10.0INS, IGF1, LEP
35hypertrophy of breast10.0LEP, IGF2, IGF1
36hepatoblastoma10.0IGF2, INSR
37congenital generalized lipodystrophy type 210.0INS, INSR, LEP
38lipodystrophy10.0LEP, INSR, INS
39insulinoma10.0IGF2, INSR, INS
40rabson-mendenhall syndrome10.0INSR, IGF1, INS
41uremia10.0INSR, IGF1, LEP
42hypertriglyceridemia10.0INS, INSR, LEP
43pre-eclampsia10.0LEP, INSR, OXT
44prader-willi syndrome10.0OXT, IGF1, INS, LEP
45hypothyroidism10.0IGF1, OXT, LEP, INS
46choriocarcinoma10.0SLC2A3, OXT, IGF2, LEP
47growth hormone deficiency10.0IGF1, IGF2, INS, LEP
48acromegaly10.0IGF1, IGF2, LEP, INS
49short stature10.0INS, LEP, IGF2, IGF1
50diabetic retinopathy10.0IGF1, INS, INSR

Graphical network of the top 20 diseases related to Fetal Macrosomia:



Diseases related to fetal macrosomia

Symptoms for Fetal Macrosomia

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Drugs & Therapeutics for Fetal Macrosomia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Fetal Macrosomia

Search NIH Clinical Center for Fetal Macrosomia

Genetic Tests for Fetal Macrosomia

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Anatomical Context for Fetal Macrosomia

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33MalaCards
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MalaCards organs/tissues related to Fetal Macrosomia:

33
Testes, Placenta

Animal Models for Fetal Macrosomia or affiliated genes

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37MGI
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Publications for Fetal Macrosomia

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52PubMed
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Articles related to Fetal Macrosomia:

(show top 50)    (show all 158)
idTitleAuthorsYear
1
Adverse maternal outcomes associated with fetal macrosomia: what are the risk factors beyond birthweight? (23565692)
2013
2
Women's perceptions and experiences of fetal macrosomia. (23786991)
2013
3
The role of umbilical cord thickness and HbA1c levels for the prediction of fetal macrosomia in patients with gestational diabetes mellitus. (21837429)
2012
4
A new formula for optimized weight estimation in extreme fetal macrosomia (a8Y 4500a88g). (22723038)
2012
5
Metformin is not significantly different from insulin for preventing fetal macrosomia in women with gestational diabetes. (21937503)
2012
6
Prediction of fetal macrosomia with ultrasound parameters and maternal glycemic controls in gestational diabetes mellitus. (23444756)
2012
7
Fetal and maternal outcomes in pregnancies complicated with fetal macrosomia. (22754881)
2012
8
Sonographic prediction of fetal macrosomia: the consequences of false diagnosis. (20103792)
2010
9
Fetal macrosomia in non-diabetic mothers: antenatal diagnosis and delivery outcome. (19358025)
2009
10
Risk factors of fetal macrosomia: role of maternal nutrition. (20180374)
2009
11
Fetal macrosomia in African women: a study of 249 cases. (19018549)
2009
12
Fetal macrosomia in pregnant women with gestational diabetes. (20102057)
2009
13
Fetal macrosomia and pregnancy outcomes. (19780734)
2009
14
Fetal macrosomia greater than or equal to 4000 grams. Comparing maternal and neonatal outcomes in diabetic and non-diabetic women. (19370296)
2009
15
Detection of pregnancies with high risk of fetal macrosomia among women with gestational diabetes mellitus. (18728914)
2008
16
Fetal weight estimation for prediction of fetal macrosomia: does additional clinical and demographic data using pattern recognition algorithm improve detection? (22439018)
2008
17
Etiology, detection, and management of fetal macrosomia in pregnancies complicated by diabetes mellitus. (17982341)
2007
18
Treatment of suspected fetal macrosomia: a cost-effectiveness analysis. (17346515)
2007
19
Intrapartum fetal abdominal circumference by ultrasonography for predicting fetal macrosomia. (17726811)
2006
20
2004 Shanghai international workshop of fetal macrosomia and adult obesity. (16100630)
2005
21
Fetal macrosomia. Risk factor and outcome. (15756361)
2005
22
Incidence of fetal macrosomia and birth complications in Chinese immigrant women. (12755347)
2003
23
Effect of fetal macrosomia on human placental glucose transport and utilization in insulin-treated gestational diabetes. (14711103)
2003
24
Fetal macrosomia (> or =4500 g): perinatal outcome of 231 cases according to the mode of delivery. (12673264)
2003
25
The amniotic fluid index as a predictor of fetal macrosomia in a Turkish population. (12706284)
2003
26
Maternal obesity not maternal glucose values correlates best with high rates of fetal macrosomia in pregnancies complicated by gestational diabetes. (12235720)
2002
27
Expectant management versus labor induction for suspected fetal macrosomia: a systematic review. (12423867)
2002
28
Perinatal and maternal outcomes of fetal macrosomia. (11788165)
2001
29
Effects of a policy of elective cesarean delivery in cases of suspected fetal macrosomia on the incidence of brachial plexus injury and the rate of cesarean delivery. (11084580)
2000
30
Maternal complications of fetal macrosomia. (10863631)
2000
31
Fetal macrosomia related to maternal poorly controlled type 1 diabetes strongly impairs serum lipoprotein concentrations and composition. (11265176)
2000
32
Prophylactic cesarean delivery for fetal macrosomia diagnosed by means of ultrasonography--A Faustian bargain? (10454678)
1999
33
Are conventional targets for metabolic control sufficient to prevent fetal macrosomia during diabetic pregnancy? (10566124)
1999
34
Screening efficacy of the subcutaneous tissue width/femur length ratio for fetal macrosomia in the non-diabetic pregnancy. (10380299)
1999
35
Labor induction with a prenatal diagnosis of fetal macrosomia. (9086425)
1997
36
Prediction of fetal macrosomia using sonographically measured abdominal subcutaneous tissue thickness. (9282803)
1997
37
On the association between maternal phosphoglucomutase 1 (PGM1) and fetal macrosomia in diabetic pregnancy. (8863716)
1996
38
Diabetes in pregnancy: fetal macrosomia, hyperinsulinism, and islet hyperplasia in the offspring of rats subjected to temporary protein-energy malnutrition early in life. (8108195)
1993
39
Fetal macrosomia and gestational diabetes: what's the problem? (8469471)
1993
40
Diabetic fetal macrosomia: significance of disproportionate growth. (8419598)
1993
41
Maternal insulin to lower the risk of fetal macrosomia in diabetic pregnancy. (1868636)
1991
42
Transplacental passage of insulin in pregnant women with insulin-dependent diabetes mellitus. Its role in fetal macrosomia. (2195347)
1990
43
Abnormal glucose screening tests in pregnancy: a risk factor for fetal macrosomia. (3822298)
1987
44
Fetal macrosomia: demographic analysis and perinatal performance in a Chinese population. (3493762)
1986
45
Fetal macrosomia in experimental maternal diabetes. (7457516)
1981
46
Fetal macrosomia in diabetic multiparous animals. (7227701)
1981
47
Fetal macrosomia and maternal diabetic control. (6786556)
1981
48
Serial ultrasonography to assess evolving fetal macrosomia. Studies in 23 pregnant diabetic women. (7373818)
1980
49
Fetal macrosomia--animal models. (6771112)
1980
50
Shoulder dystocia. A complication of fetal macrosomia and prolonged second stage of labor with midpelvic delivery. (724169)
1978

Variations for Fetal Macrosomia

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Expression for genes affiliated with Fetal Macrosomia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fetal Macrosomia

Search GEO for disease gene expression data for Fetal Macrosomia.

Pathways for genes affiliated with Fetal Macrosomia

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Sources:
50PathCards, 38NCBI BioSystems Database, 61Tocris Bioscience, 30KEGG, 51PharmGKB, 60Thomson Reuters, 12EMD Millipore, 55Reactome, 54R&D Systems, 53QIAGEN
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Pathways related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7LEP, PGM1
29.5INSR, LEP
3
Show member pathways
Insulin Pathway38
9.5INS, INSR
49.5INSR, INS
5
Show member pathways
9.5INSR, INS
69.5INSR, INS
79.5INSR, INS
89.5INSR, INS
99.5SLC2A3, INS
109.5IGF1, IGF2
119.5IGF2, IGF1
12
Show member pathways
9.1INS, INSR, LEP
139.1LEP, INSR, INS
14
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.1LEP, INSR, INS
159.1INS, INSR, LEP
16
Show member pathways
9.1LEP, INSR, INS
179.0IGF1, IGF2, INS
18
Show member pathways
9.0LEP, INS, IGF1
199.0LEP, INS, IGF1
20
Show member pathways
9.0INSR, IGF2, IGF1
21
Show member pathways
9.0INSR, IGF2, IGF1
22
Show member pathways
9.0INSR, IGF2, IGF1
23
Show member pathways
9.0IGF1, IGF2, INSR
248.9INSR, INS, IGF1
25
Show member pathways
8.9INSR, INS, IGF1
268.9IGF1, INS, INSR
278.9IGF1, INS, INSR
28
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.9IGF1, INS, INSR
298.9IGF1, INS, INSR
30
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
8.9IGF1, INS, INSR
31
Show member pathways
8.6LEP, INS, IGF2, IGF1
32
Show member pathways
8.5INSR, INS, IGF2, IGF1
33
Show member pathways
8.5IGF1, IGF2, INS, INSR
34
Show member pathways
8.5IGF1, IGF2, INS, INSR
35
Show member pathways
8.5IGF1, IGF2, INS, INSR
36
Show member pathways
7.3IGF1, IGF2, INS, INSR, LEP, OXT

Compounds for genes affiliated with Fetal Macrosomia

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1poly(glu(80)tyr(20))459.8INS, INSR
2chromium picolinate459.5INS, INSR
3cetrorelix45 29 1111.4LEP, IGF1, IGF2
4megestrol acetate459.4LEP, IGF2, IGF1
5ag 1024459.4INSR, IGF1, IGF2
6acipimox45 2910.3LEP, INS, IGF1
72,4-dinitrophenol459.3SLC2A3, IGF2, IGF1
8cortisone45 2410.3INS, IGF1, LEP
9mecasermin45 1110.3INSR, IGF1, INS
10fenofibrate45 51 1111.2LEP, INSR, INS
11insulin (human) recombinant619.2IGF1, INSR
12clomiphene citrate459.2IGF1, INSR, INS
13glibenclamide45 29 51 6112.2LEP, INSR, INS
14pioglitazone29 45 51 1112.1INS, LEP, INSR, IGF2
15l-nmma459.1IGF1, LEP, INSR
16dehydroepiandrosterone sulfate459.0IGF2, INS, IGF1, LEP
17picropodophyllotoxin619.0IGF1, INSR
18dhea459.0LEP, INS, IGF2, IGF1
19androstenedione45 2410.0INS, LEP, IGF1, IGF2
20octreotide45 61 29 1111.9INSR, IGF2, IGF1, INS
21aicar45 24 1110.9IGF1, LEP, INS, INSR
22streptozotocin458.9INS, INSR, OXT
23dihydrotestosterone45 29 24 1111.9IGF1, IGF2, INSR, LEP
24metformin45 51 1110.9LEP, INS, IGF1, INSR
25hydrocortisone45 3 61 1111.9IGF1, IGF2, INS, INSR
26ibmx45 61 2910.9INSR, IGF1, INS, IGF2
27ascorbic acid45 249.6OXT, LEP, SLC2A3, IGF2
28epinephrine45 24 1110.5INS, INSR, LEP, OXT
29c-peptide458.5LEP, INSR, IGF2, INS, IGF1
30progestin458.5OXT, IGF2, IGF1, INSR
31rapamycin458.5IGF1, IGF2, INS, LEP, INSR
32norepinephrine45 24 1110.5IGF2, OXT, LEP, INS
33ly294002458.5IGF1, INSR, INS, IGF2, LEP
34wortmannin458.5INSR, IGF1, INS, LEP
352-deoxyglucose45 119.4INS, IGF2, IGF1, INSR, SLC2A3
36dexamethasone45 51 29 1111.4IGF1, INSR, INS, IGF2, LEP
37cycloheximide458.3LEP, IGF2, INSR, IGF1, SLC2A3
38phosphatidylinositol458.3IGF2, LEP, INSR, INS, IGF1
39acth458.2IGF1, IGF2, INS, LEP, OXT
40gnrh458.2OXT, INS, IGF2, IGF1, LEP
41glutamate458.1INS, IGF2, LEP, OXT, INSR
42progesterone45 29 61 24 1112.0IGF2, LEP, OXT, SLC2A3, IGF1
43thyroxine45 248.7LEP, OXT, INSR, INS, IGF2, IGF1
44creatinine457.7INSR, IGF2, IGF1, LEP, OXT, INS
45testosterone45 61 24 1110.7IGF1, IGF2, INS, INSR, LEP, OXT
46arginine457.7LEP, OXT, IGF2, INSR, IGF1, INS
47glucose457.7IGF2, INSR, LEP, PGM1, INS, SLC2A3
48estrogen457.6OXT, IGF2, INS, INSR, LEP, IGF1
49vegf457.6IGF1, OXT, SLC2A3, LEP, INSR, IGF2
50serine457.5IGF2, OXT, LEP, INSR, IGF1, INS

GO Terms for genes affiliated with Fetal Macrosomia

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16Gene Ontology
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Cellular components related to Fetal Macrosomia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5IGF2, IGF1
2extracellular spaceGO:0056157.7LEP, IGF1, IGF2, INS, OXT
3extracellular regionGO:0055767.5OXT, IGF1, IGF2, INS, LEP

Biological processes related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of developmental growthGO:0486399.8LEP, INSR
2positive regulation of respiratory burstGO:0602679.7INS, INSR
3bone mineralization involved in bone maturationGO:0356309.7LEP, IGF1
4activation of protein kinase B activityGO:0321489.7INSR, INS
5positive regulation of activated T cell proliferationGO:0421049.7IGF2, IGF1
6positive regulation of nitric oxide biosynthetic processGO:0454299.6INSR, INS
7positive regulation of insulin receptor signaling pathwayGO:0466289.6LEP, IGF2, INS
8eating behaviorGO:0427559.4OXT, LEP
9insulin receptor signaling pathwayGO:0082869.3INSR, IGF2, INS
10exocrine pancreas developmentGO:0310179.3INSR, IGF2, IGF1
11positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.3INS, IGF1
12positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.3IGF1, IGF2, INS
13memoryGO:0076139.3IGF2, OXT
14response to estradiolGO:0323559.3OXT, IGF2
15glucose metabolic processGO:0060069.2PGM1, INS, LEP, IGF2
16positive regulation of glycolytic processGO:0458219.2INSR, INS, IGF1
17glucose transportGO:0157589.2SLC2A3, INS
18positive regulation of glucose importGO:0463269.2INSR, INS, IGF1
19positive regulation of DNA replicationGO:0457409.2INS, IGF1, INSR
20carbohydrate metabolic processGO:0059759.2SLC2A3, PGM1, INSR
21female pregnancyGO:0075659.1OXT, LEP, IGF2
22positive regulation of glycogen biosynthetic processGO:0457258.9IGF2, INS, IGF1, INSR
23positive regulation of mitosisGO:0458408.9IGF2, INS, INSR, IGF1
24positive regulation of protein kinase B signalingGO:0518978.8IGF2, INS, IGF1, INSR
25positive regulation of MAPK cascadeGO:0434108.5IGF2, INS, INSR, LEP, IGF1
26positive regulation of cell proliferationGO:0082848.4IGF1, INS, IGF2, INSR, LEP

Molecular functions related to Fetal Macrosomia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.1LEP, IGF2, IGF1
2insulin receptor bindingGO:0051588.7INS, IGF2, IGF1
3hormone activityGO:0051798.5IGF1, IGF2, INS, LEP
4insulin-like growth factor receptor bindingGO:0051598.5INSR, INS, IGF2, IGF1

Products for genes affiliated with Fetal Macrosomia

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Sources for Fetal Macrosomia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet