MCID: FTL021
MIFTS: 37

Fetal Macrosomia malady

Summaries for Fetal Macrosomia

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Large for gestational age (LGA) is an indication of high prenatal growth rate. LGA is often defined as a... more...

MalaCards: Fetal Macrosomia is related to gestational diabetes and hypoglycemia. An important gene associated with Fetal Macrosomia is PGM1 (phosphoglucomutase 1), and among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The compounds dehydroepiandrosterone sulfate and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include placenta, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Fetal Macrosomia

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
See all sources

Aliases & Descriptions:

fetal macrosomia 43 45 61


Related Diseases for Fetal Macrosomia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Fetal Macrosomia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1gestational diabetes31.0INS, INSR, OXT, SLC2A3, LEP
2hypoglycemia30.3GLS2, SLC2A3, INSR, INS, IGF2, IGF1
3hyperinsulinism30.1INSR, IGF2, INS, IGF1, LEP
4insulin resistance30.1INSR, LEP, IGF2, SLC2A3, IGF1, INS
5polyhydramnios10.1
6hypoxia10.1
7diabetes insipidus10.0OXT
8sarcoma10.0IGF2
9histiocytosis10.0PGM1
10bulimia nervosa10.0LEP
11acquired generalized lipodystrophy10.0LEP
12rhabdomyosarcoma10.0IGF2
13cushing's syndrome10.0INS
14hemihypertrophy10.0IGF2
15blindness10.0INS
16turner syndrome10.0IGF1
17lung cancer10.0IGF1
18leiomyosarcoma10.0IGF2
19pancreatitis10.0INS
20lactic acidosis10.0INS
21craniopharyngioma10.0IGF1
22sheehan syndrome10.0IGF1
23proliferative diabetic retinopathy10.0IGF1
24gigantism10.0IGF1
25neonatal diabetes mellitus10.0INS
26cystic fibrosis10.0INS
27panhypopituitarism10.0IGF1
28ischemia10.0INSR
29myotonic dystrophy10.0INSR
30arthritis10.0LEP
31myoma10.0OXT
32dementia10.0INSR
33infertility10.0INS, LEP
34adenocarcinoma10.0INSR
35adrenal adenoma10.0IGF2
36hypoglycemic coma10.0INS, IGF2
37coronary heart disease10.0LEP, INS
38laron syndrome10.0IGF2, IGF1
39hyperinsulinemic hypoglycemia10.0IGF2, INS
40werner syndrome10.0INSR
41familial partial lipodystrophy10.0LEP, INS
42eating disorder10.0INS, LEP
43insulin-like growth factor 1 resistance to10.0IGF2, IGF1
44myopathy10.0IGF1, INS
45melanoma10.0INSR
46meningioma10.0SLC2A3, IGF2
47glioblastoma multiforme10.0OXT, SLC2A3
48pituitary adenoma10.0LEP, IGF1
49morbid obesity10.0LEP, INS
50retinoblastoma10.0INSR

Graphical network of the top 20 diseases related to Fetal Macrosomia:



Diseases related to fetal macrosomia

Clinical Features for Fetal Macrosomia

Drugs & Therapeutics for Fetal Macrosomia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Fetal Macrosomia

Drug clinical trials:

Search ClinicalTrials for Fetal Macrosomia

Search NIH Clinical Center for Fetal Macrosomia

Search CenterWatch for Fetal Macrosomia

Genetic Tests for Fetal Macrosomia

Anatomical Context for Fetal Macrosomia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Fetal Macrosomia:

33
Placenta

Animal Models for Fetal Macrosomia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Fetal Macrosomia

Sources:
51PubMed
See all sources

Articles related to Fetal Macrosomia:

(show top 50)    (show all 161)
idTitleAuthorsYear
1
Amniotic fluid insulin and C-peptide as predictive markers for fetal macrosomia, birth injuries, and delivery complications? (24423633)
2014
2
Women's perceptions and experiences of fetal macrosomia. (23786991)
2013
3
Prenatal detection and consequences of fetal macrosomia. (23221275)
2013
4
Fetal macrosomia in Japanese women. (23279000)
2013
5
Following the 2009 American Institute of Medicine recommendations for normal body mass index and overweight women led to an increased risk of fetal macrosomia among Taiwanese women. (24075370)
2013
6
Fetal macrosomia: risk factors, maternal, and perinatal outcome. (24380006)
2013
7
The role of umbilical cord thickness and HbA1c levels for the prediction of fetal macrosomia in patients with gestational diabetes mellitus. (21837429)
2012
8
A new formula for optimized weight estimation in extreme fetal macrosomia (a8Y 4500a88g). (22723038)
2012
9
Fetal and maternal outcomes in pregnancies complicated with fetal macrosomia. (22754881)
2012
10
HNF1A mutation presenting with fetal macrosomia and hypoglycemia in childhood prior to onset of overt diabetes. (21648289)
2011
11
Retraction. Relationship of adiponectin and resistin levels in umbilical and maternal serum with fetal macrosomia. (22128395)
2011
12
Risk factors of fetal macrosomia: role of maternal nutrition. (20180374)
2009
13
Fetal macrosomia and pregnancy outcomes. (19780734)
2009
14
Fetal macrosomia greater than or equal to 4000 grams. Comparing maternal and neonatal outcomes in diabetic and non-diabetic women. (19370296)
2009
15
How big is too big? The perinatal consequences of fetal macrosomia. (18455528)
2008
16
2004 Shanghai international workshop of fetal macrosomia and adult obesity. (16100630)
2005
17
Fetal macrosomia. Risk factor and outcome. (15756361)
2005
18
Treatment of suspected fetal macrosomia: a cost-effectiveness analysis. (16157107)
2005
19
Fetal weight estimation in diabetic pregnancies and suspected fetal macrosomia. (15085885)
2004
20
Accuracy of sonographic estimation of fetal weight before induction of labor in diabetic pregnancies and pregnancies with suspected fetal macrosomia. (12825478)
2003
21
A case control study of the prevalence of perinatal complications associated with fetal macrosomia in Antigua and Barbuda. (14649106)
2003
22
Gestational diabetes versus obesity as risk factors for pregnancy-induced hypertensive disorders and fetal macrosomia. (11926638)
2002
23
Physicians who induce labor for fetal macrosomia do not reduce cesarean delivery rates. (11324367)
2001
24
Maternal complications of fetal macrosomia. (10863631)
2000
25
Fetal macrosomia related to maternal poorly controlled type 1 diabetes strongly impairs serum lipoprotein concentrations and composition. (11265176)
2000
26
Sonographic EFW and macrosomia: is there an optimum formula to predict diabetic fetal macrosomia? (10757437)
2000
27
Ultrasonographic prediction of fetal macrosomia. Association with cesarean delivery. (10664942)
2000
28
Fetal macrosomia: etiologic factors. (10863626)
2000
29
Are conventional targets for metabolic control sufficient to prevent fetal macrosomia during diabetic pregnancy? (10566124)
1999
30
Screening efficacy of the subcutaneous tissue width/femur length ratio for fetal macrosomia in the non-diabetic pregnancy. (10380299)
1999
31
A study of fetal macrosomia. (10728630)
1999
32
Fetal weight estimation and prediction of fetal macrosomia in non-diabetic pregnant women. (10221609)
1999
33
When is fetal macrosomia (> or = 4500 g) an indication for caesarean section? (8794545)
1996
34
Fetal macrosomia: does antenatal prediction affect delivery route and birth outcome? (7485323)
1995
35
Whither ultrasonic prediction of fetal macrosomia? (8414339)
1993
36
Prediction of fetal macrosomia by single ultrasonic fetal biometry. (8099822)
1993
37
Ultrasound diagnosis of fetal macrosomia. (12797002)
1992
38
Fetal macrosomia in a military hospital: incidence, risk factors, and outcome. (1900588)
1991
39
Transplacental passage of insulin in pregnant women with insulin-dependent diabetes mellitus. Its role in fetal macrosomia. (2195347)
1990
40
Vaginal birth after cesarean: is suspected fetal macrosomia a contraindication? (2314795)
1990
41
Fetal macrosomia--maternal risks and fetal outcome. (1972112)
1990
42
Fetal macrosomia as an important indicator of fetal malformation syndrome: ultrasonic findings of two cases. (2676641)
1989
43
Fetal macrosomia and pregnancy outcome in Lagos. (2564355)
1989
44
Abnormal glucose screening in pregnancy in patients with normal oral glucose tolerance tests as a screening test for fetal macrosomia. (2903083)
1988
45
Prediction and consequences of fetal macrosomia. (3694183)
1987
46
Relative fetal hypoxia as a contributing factor to fetal macrosomia in diabetic pregnancy. (6646003)
1983
47
Ultrasonic prediction of fetal macrosomia in diabetic patients. (7155475)
1982
48
Fetal macrosomia in experimental maternal diabetes. (7457516)
1981
49
A new animal model for fetal macrosomia in diabetic pregnancy. (7308414)
1981
50
Fetal macrosomia and maternal diabetic control in pregnancy. (6780064)
1981

Genetic Variations for Fetal Macrosomia

Expression for genes affiliated with Fetal Macrosomia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Fetal Macrosomia

Search GEO for disease gene expression data for Fetal Macrosomia.

Pathways for genes affiliated with Fetal Macrosomia

Sources:
52QIAGEN, 53R&D Systems, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0INSR
2
Hide members
10.0INSR
3
Hide members
9.7LEP, INS
49.6INSR, INS
5
Transcription Transcription factor Tubby signaling pathways
Hide members
9.6INSR, INS
69.6INS, INSR
7
Hide members
9.6INSR, INS
89.6IGF1, IGF2
99.2INS, INSR, LEP
109.2INS, INSR, LEP
119.2INS, INSR, LEP
129.2INS, IGF1, IGF2
139.2LEP, INS, IGF1
149.1INSR, INS, IGF1
159.1IGF1, INS, INSR
169.1IGF1, INS, INSR
17
Hide members
8.7IGF2, IGF1, INS, INSR
18
Hide members
8.7INSR, INS, IGF1, IGF2
19
Hide members
8.7INSR, INS, IGF1, IGF2
20
Hide members
8.7IGF2, IGF1, INS, INSR

Compounds for genes affiliated with Fetal Macrosomia

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1dehydroepiandrosterone sulfate4510.6IGF2
2cycloheximide4510.2SLC2A3
3glutamate4510.0GLS2
42,4-dinitrophenol4510.0IGF2, SLC2A3
5poly(glu(80)tyr(20))459.9INSR, INS
6insulin (human) recombinant609.7INSR, IGF1
7bms 536924609.6IGF1, INSR
8cetrorelix45 29 1111.6IGF2, IGF1, LEP
9megestrol acetate459.6LEP, IGF1, IGF2
10demethylasterriquinone b1609.6IGF1, INSR
11chromium picolinate459.6INS, INSR
12ag 1024459.6INSR, IGF1, IGF2
13picropodophyllotoxin609.6IGF1, INSR
14acipimox45 2910.5IGF1, INS, LEP
15mecasermin45 1110.5INS, INSR, IGF1
16cortisone45 2410.5LEP, INS, IGF1
17clomiphene citrate459.4INSR, IGF1, INS
18fenofibrate45 50 1111.4INSR, LEP, INS
19l-nmma459.3INSR, LEP, IGF1
20pioglitazone45 50 29 1112.3INS, INSR, LEP, IGF2
21dexamethasone45 50 29 1112.3INS, INSR, IGF2
22dhea459.2IGF2, IGF1, LEP, INS
23streptozotocin459.2OXT, INSR, INS
24androstenedione45 2410.2IGF2, LEP, INS, IGF1
25octreotide45 60 29 1112.2IGF2, INSR, INS, IGF1
26aicar45 11 2411.2INSR, IGF1, INS, LEP
27metformin45 50 1111.1INS, INSR, IGF1, LEP
28dihydrotestosterone45 29 11 2412.1INSR, IGF2, IGF1, LEP
29hydrocortisone45 2 60 1112.1INSR, INS, IGF1, IGF2
30ibmx45 29 6011.1IGF2, INS, INSR, IGF1
31glibenclamide45 29 50 6011.9INS, INSR, LEP
32progestin458.9IGF2, IGF1, OXT, INSR
33epinephrine45 11 2410.9INS, INSR, LEP, OXT
34c-peptide458.8INS, INSR, LEP, IGF1, IGF2
35rapamycin458.8IGF2, IGF1, INS, INSR, LEP
36ly294002458.7IGF2, IGF1, INS, INSR, LEP
372-deoxyglucose45 119.7INS, IGF2, INSR, SLC2A3, IGF1
38acth458.6INS, LEP, OXT, IGF2, IGF1
39ascorbic acid45 249.5LEP, OXT, SLC2A3, IGF2
40gaba458.5INSR, LEP, GLS2, OXT
41glucose458.5PGM1, GLS2, IGF2, INSR, IGF1
42progesterone45 60 29 11 2412.4OXT, LEP, SLC2A3, IGF1, IGF2
43glycogen45 249.3IGF2, INS, INSR, SLC2A3, GLS2
44thyroxine45 249.2IGF2, INSR, LEP, IGF1, INS, OXT
45creatinine458.2OXT, IGF2, IGF1, LEP, INSR, INS
46testosterone45 60 11 2411.2INS, IGF1, IGF2, INSR, OXT, LEP
47estrogen458.1LEP, INSR, OXT, IGF1, INS, IGF2
48glutamine458.0INSR, OXT, IGF1, IGF2, GLS2
49vegf458.0IGF2, SLC2A3, IGF1, OXT, INSR, LEP
50arginine457.4LEP, INSR, INS, GLS2, OXT, IGF1

GO Terms for genes affiliated with Fetal Macrosomia

Sources:
16Gene Ontology
See all sources

Cellular components related to Fetal Macrosomia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2IGF1, OXT, INS, LEP, IGF2
2extracellular spaceGO:0056157.9LEP, INS, OXT, IGF1, IGF2

Biological processes related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of developmental growthGO:0486399.9LEP, INSR
2positive regulation of respiratory burstGO:0602679.8INSR, INS
3bone mineralization involved in bone maturationGO:0356309.8LEP, IGF1
4positive regulation of insulin receptor signaling pathwayGO:0466289.7IGF2, INS, LEP
5exocrine pancreas developmentGO:0310179.6INSR, IGF1
6activation of protein kinase B activityGO:0321489.6INS, INSR
7positive regulation of nitric oxide biosynthetic processGO:0454299.6INSR, INS
8positive regulation of activated T cell proliferationGO:0421049.5IGF1, IGF2
9positive regulation of glycolysisGO:0458219.4IGF1, INS, INSR
10positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.3IGF2, IGF1, INS
11positive regulation of glucose importGO:0463269.3INSR, INS, IGF1
12insulin receptor signaling pathwayGO:0082869.3INSR, INS, IGF2
13positive regulation of DNA replicationGO:0457409.3IGF1, INS, INSR
14glucose metabolic processGO:0060069.3LEP, PGM1, INS, IGF2
15eating behaviorGO:0427559.2LEP, OXT
16positive regulation of glycogen biosynthetic processGO:0457259.1IGF2, IGF1, INS, INSR
17positive regulation of mitosisGO:0458409.1INSR, INS, IGF1, IGF2
18positive regulation of protein kinase B signaling cascadeGO:0518979.0INSR, INS, IGF1, IGF2
19positive regulation of MAPK cascadeGO:0434108.7LEP, INSR, INS, IGF1, IGF2
20positive regulation of cell proliferationGO:0082848.6IGF2, IGF1, INS, INSR, LEP

Molecular functions related to Fetal Macrosomia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.2LEP, IGF1, IGF2
2insulin receptor bindingGO:0051588.9INS, IGF1, IGF2
3insulin-like growth factor receptor bindingGO:0051598.7INSR, INS, IGF1, IGF2
4hormone activityGO:0051798.7IGF2, IGF1, INS, LEP

Products for genes affiliated with Fetal Macrosomia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fetal Macrosomia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet