MCID: FTL021
MIFTS: 43

Fetal Macrosomia malady

Rare diseases category

Summaries for Fetal Macrosomia

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MalaCards based summary: Fetal Macrosomia is related to obesity and hypoglycemia. An important gene associated with Fetal Macrosomia is PGM1 (phosphoglucomutase 1), and among its related pathways are HIF-1-alpha transcription factor network and AMPK signaling. The compounds poly(glu(80)tyr(20)) and cetrorelix have been mentioned in the context of this disorder. Affiliated tissues include testes and placenta, and related mouse phenotypes are liver/biliary system and respiratory system.

Aliases & Classifications for Fetal Macrosomia

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Sources:
43NIH Rare Diseases, 45Novoseek, 62UMLS
See all sources

Fetal Macrosomia, Aliases & Descriptions:

Name: Fetal Macrosomia 43 45 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Fetal Macrosomia

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Diseases related to Fetal Macrosomia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.7SLC2A3, INS, LEP, INSR, IGF1
2hypoglycemia30.4IGF2, IGF1, INSR, OXT, SLC2A3, INS
3hyperinsulinemic hypoglycemia30.2INS
4protein-energy malnutrition30.2IGF1, LEP
5hyperinsulinism30.1INS, LEP, IGF2, INSR, IGF1
6insulin-like growth factor i10.1
7polyhydramnios10.1
8vaginitis10.1
9hypoxia10.1
10acquired generalized lipodystrophy10.1LEP
11hemi 3 syndrome10.0IGF2
12laron dwarfism10.0IGF2, IGF1
13insulin-like growth factor 1 resistance to10.0IGF2, IGF1
14hypoglycemic coma10.0INS, IGF2
15familial partial lipodystrophy10.0LEP, INS
16pituitary gland disease10.0INS, IGF1
17eating disorder10.0INS, LEP
18precocious puberty10.0LEP, IGF1
19morbid obesity10.0LEP, INS
20leprechaunism10.0INS, INSR
21uterine fibroid10.0IGF2, OXT, IGF1
22fatty liver disease10.0LEP, INS
23anorexia nervosa10.0LEP, OXT, IGF1
24cushing's syndrome10.0IGF1, LEP
25anovulation10.0INS, IGF1, LEP
26amenorrhea10.0LEP, IGF1, INS
27hypopituitarism10.0IGF1, INS, LEP
28hypogonadism10.0IGF1, LEP, INS
29liver disease10.0IGF1, LEP, INS
30congenital heart disease10.0INS, IGF1, LEP
31hepatoblastoma10.0IGF2, INSR
32berardinelli-seip congenital lipodystrophy10.0INS, INSR, LEP
33lipodystrophy10.0LEP, INSR, INS
34rabson-mendenhall syndrome10.0INSR, IGF1, INS
35uremia10.0INSR, IGF1, LEP
36insulinoma10.0IGF2, INSR, INS
37hypertriglyceridemia10.0INS, INSR, LEP
38prader-willi syndrome10.0OXT, IGF1, INS, LEP
39lipid metabolism disorder10.0INS, LEP, INSR
40hypothyroidism10.0IGF1, OXT, LEP, INS
41choriocarcinoma10.0SLC2A3, OXT, IGF2, LEP
42preeclampsia/eclampsia 110.0LEP, INSR, OXT
43growth hormone deficiency10.0IGF1, IGF2, INS, LEP
44acromegaly10.0IGF1, IGF2, LEP, INS
45microvascular complications of diabetes 510.0IGF1, INS, INSR
46hypertension, essential10.0LEP, INSR, INS
47chronic kidney failure10.0INS, IGF2, IGF1, LEP
48endometrial cancer10.0IGF2, IGF1, INSR
49atherosclerosis10.0LEP, INS, IGF1
50leiomyoma10.0IGF2, INSR

Graphical network of the top 20 diseases related to Fetal Macrosomia:



Diseases related to fetal macrosomia

Symptoms for Fetal Macrosomia

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Drugs & Therapeutics for Fetal Macrosomia

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Drug clinical trials:

Search ClinicalTrials for Fetal Macrosomia

Search NIH Clinical Center for Fetal Macrosomia

Genetic Tests for Fetal Macrosomia

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Anatomical Context for Fetal Macrosomia

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MalaCards organs/tissues related to Fetal Macrosomia:

33
Testes, Placenta

Animal Models for Fetal Macrosomia or affiliated genes

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Publications for Fetal Macrosomia

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Articles related to Fetal Macrosomia:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Maternal obesity and occurrence of fetal macrosomia: a systematic review and meta-analysis. (25544943)
2014
2
Third trimester insulin levels are not correlated with fetal macrosomia or delivery complications. (24937972)
2014
3
Physical activity, sedentary behaviour and fetal macrosomia in uncomplicated pregnancies: A prospective cohort study. (24861673)
2014
4
Adverse maternal outcomes associated with fetal macrosomia: what are the risk factors beyond birthweight? (23565692)
2013
5
Women's perceptions and experiences of fetal macrosomia. (23786991)
2013
6
The role of umbilical cord thickness and HbA1c levels for the prediction of fetal macrosomia in patients with gestational diabetes mellitus. (21837429)
2012
7
A new formula for optimized weight estimation in extreme fetal macrosomia (a8Y 4500a88g). (22723038)
2012
8
Metformin is not significantly different from insulin for preventing fetal macrosomia in women with gestational diabetes. (21937503)
2012
9
Prediction of fetal macrosomia with ultrasound parameters and maternal glycemic controls in gestational diabetes mellitus. (23444756)
2012
10
Fetal and maternal outcomes in pregnancies complicated with fetal macrosomia. (22754881)
2012
11
Sonographic prediction of fetal macrosomia: the consequences of false diagnosis. (20103792)
2010
12
Fetal macrosomia in non-diabetic mothers: antenatal diagnosis and delivery outcome. (19358025)
2009
13
Risk factors of fetal macrosomia: role of maternal nutrition. (20180374)
2009
14
Fetal macrosomia in African women: a study of 249 cases. (19018549)
2009
15
Fetal macrosomia in pregnant women with gestational diabetes. (20102057)
2009
16
Fetal macrosomia and pregnancy outcomes. (19780734)
2009
17
Fetal macrosomia greater than or equal to 4000 grams. Comparing maternal and neonatal outcomes in diabetic and non-diabetic women. (19370296)
2009
18
Detection of pregnancies with high risk of fetal macrosomia among women with gestational diabetes mellitus. (18728914)
2008
19
Fetal weight estimation for prediction of fetal macrosomia: does additional clinical and demographic data using pattern recognition algorithm improve detection? (22439018)
2008
20
Etiology, detection, and management of fetal macrosomia in pregnancies complicated by diabetes mellitus. (17982341)
2007
21
Treatment of suspected fetal macrosomia: a cost-effectiveness analysis. (17346515)
2007
22
Intrapartum fetal abdominal circumference by ultrasonography for predicting fetal macrosomia. (17726811)
2006
23
2004 Shanghai international workshop of fetal macrosomia and adult obesity. (16100630)
2005
24
Fetal macrosomia. Risk factor and outcome. (15756361)
2005
25
Incidence of fetal macrosomia and birth complications in Chinese immigrant women. (12755347)
2003
26
Effect of fetal macrosomia on human placental glucose transport and utilization in insulin-treated gestational diabetes. (14711103)
2003
27
Fetal macrosomia (> or =4500 g): perinatal outcome of 231 cases according to the mode of delivery. (12673264)
2003
28
The amniotic fluid index as a predictor of fetal macrosomia in a Turkish population. (12706284)
2003
29
Maternal obesity not maternal glucose values correlates best with high rates of fetal macrosomia in pregnancies complicated by gestational diabetes. (12235720)
2002
30
Perinatal and maternal outcomes of fetal macrosomia. (11788165)
2001
31
Effects of a policy of elective cesarean delivery in cases of suspected fetal macrosomia on the incidence of brachial plexus injury and the rate of cesarean delivery. (11084580)
2000
32
Maternal complications of fetal macrosomia. (10863631)
2000
33
Fetal macrosomia related to maternal poorly controlled type 1 diabetes strongly impairs serum lipoprotein concentrations and composition. (11265176)
2000
34
Prophylactic cesarean delivery for fetal macrosomia diagnosed by means of ultrasonography--A Faustian bargain? (10454678)
1999
35
Are conventional targets for metabolic control sufficient to prevent fetal macrosomia during diabetic pregnancy? (10566124)
1999
36
Screening efficacy of the subcutaneous tissue width/femur length ratio for fetal macrosomia in the non-diabetic pregnancy. (10380299)
1999
37
Labor induction with a prenatal diagnosis of fetal macrosomia. (9086425)
1997
38
Prediction of fetal macrosomia using sonographically measured abdominal subcutaneous tissue thickness. (9282803)
1997
39
On the association between maternal phosphoglucomutase 1 (PGM1) and fetal macrosomia in diabetic pregnancy. (8863716)
1996
40
Diabetes in pregnancy: fetal macrosomia, hyperinsulinism, and islet hyperplasia in the offspring of rats subjected to temporary protein-energy malnutrition early in life. (8108195)
1993
41
Fetal macrosomia and gestational diabetes: what's the problem? (8469471)
1993
42
Diabetic fetal macrosomia: significance of disproportionate growth. (8419598)
1993
43
Maternal insulin to lower the risk of fetal macrosomia in diabetic pregnancy. (1868636)
1991
44
Transplacental passage of insulin in pregnant women with insulin-dependent diabetes mellitus. Its role in fetal macrosomia. (2195347)
1990
45
Fetal macrosomia: demographic analysis and perinatal performance in a Chinese population. (3493762)
1986
46
Fetal macrosomia in experimental maternal diabetes. (7457516)
1981
47
Fetal macrosomia in diabetic multiparous animals. (7227701)
1981
48
Serial ultrasonography to assess evolving fetal macrosomia. Studies in 23 pregnant diabetic women. (7373818)
1980
49
Fetal macrosomia--animal models. (6771112)
1980
50
Shoulder dystocia. A complication of fetal macrosomia and prolonged second stage of labor with midpelvic delivery. (724169)
1978

Variations for Fetal Macrosomia

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Expression for genes affiliated with Fetal Macrosomia

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Search GEO for disease gene expression data for Fetal Macrosomia.

Pathways for genes affiliated with Fetal Macrosomia

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Pathways related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PGM1, LEP
29.5INSR, LEP
3
Show member pathways
9.5INSR, INS
4
Show member pathways
Insulin Pathway38
9.5INSR, INS
59.5INSR, INS
69.5INSR, INS
79.5INSR, INS
89.5INSR, INS
99.5SLC2A3, INS
109.5IGF2, IGF1
119.5IGF2, IGF1
12
Show member pathways
9.1LEP, INSR, INS
139.1LEP, INSR, INS
14
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.1INSR, LEP, INS
15
Show member pathways
9.1LEP, INSR, INS
169.1INSR, INS, LEP
179.0INS, IGF2, IGF1
189.0INS, LEP, IGF1
19
Show member pathways
9.0IGF1, INS, LEP
20
Show member pathways
9.0IGF1, IGF2, INSR
21
Show member pathways
9.0IGF1, IGF2, INSR
22
Show member pathways
9.0INSR, IGF1, IGF2
23
Show member pathways
9.0INSR, IGF1, IGF2
24
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.9INSR, INS, IGF1
258.9INS, INSR, IGF1
268.9IGF1, INS, INSR
278.9IGF1, INS, INSR
288.9IGF1, INS, INSR
29
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
8.9INS, IGF1, INSR
30
Show member pathways
8.9IGF1, INS, INSR
31
Show member pathways
8.6IGF2, INS, IGF1, LEP
32
Show member pathways
8.5INS, IGF1, IGF2, INSR
33
Show member pathways
8.5IGF2, INS, IGF1, INSR
34
Show member pathways
8.5IGF1, IGF2, INS, INSR
35
Show member pathways
8.5IGF2, INS, IGF1, INSR
36
Show member pathways
7.3INS, INSR, OXT, LEP, IGF2, IGF1

Compounds for genes affiliated with Fetal Macrosomia

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Compounds related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1poly(glu(80)tyr(20))459.8INS, INSR
2cetrorelix45 30 1311.4IGF1, LEP, IGF2
3megestrol acetate459.4LEP, IGF2, IGF1
4ag 1024459.4INSR, IGF1, IGF2
5acipimox45 3010.3IGF1, LEP, INS
62,4-dinitrophenol459.3SLC2A3, IGF2, IGF1
7picropodophyllotoxin619.3IGF1, INSR
8cortisone45 2610.3INS, IGF1, LEP
9mecasermin45 1310.3INSR, IGF1, INS
10fenofibrate45 51 1311.2INSR, INS, LEP
11demethylasterriquinone b1619.2IGF1, INSR
12clomiphene citrate459.2IGF1, INSR, INS
13glibenclamide45 30 51 6112.2LEP, INS, INSR
14pioglitazone30 45 51 1312.1INS, LEP, INSR, IGF2
15l-nmma459.1INSR, IGF1, LEP
16dehydroepiandrosterone sulfate459.0IGF2, INS, IGF1, LEP
17insulin (human) recombinant619.0IGF1, INSR
18dhea459.0LEP, INS, IGF2, IGF1
19androstenedione45 2610.0INS, LEP, IGF1, IGF2
20octreotide45 61 30 1311.9INSR, IGF2, IGF1, INS
21aicar45 26 1310.9IGF1, LEP, INS, INSR
22streptozotocin458.9INS, INSR, OXT
23dihydrotestosterone45 30 26 1311.9IGF1, IGF2, INSR, LEP
24metformin45 51 1310.9LEP, INS, IGF1, INSR
25hydrocortisone45 3 61 1311.9IGF1, IGF2, INS, INSR
26ibmx45 61 3010.9INSR, INS, IGF1, IGF2
27ascorbic acid45 269.6OXT, LEP, SLC2A3, IGF2
28epinephrine45 26 1310.5INS, INSR, LEP, OXT
29c-peptide458.5LEP, INSR, IGF2, INS, IGF1
30progestin458.5OXT, IGF2, IGF1, INSR
31rapamycin458.5IGF1, IGF2, INS, LEP, INSR
32norepinephrine45 26 1310.5IGF2, INS, LEP, OXT
33ly294002458.5IGF1, LEP, INSR, INS, IGF2
34wortmannin458.5INSR, LEP, INS, IGF1
352-deoxyglucose45 139.4INS, IGF2, IGF1, INSR, SLC2A3
36dexamethasone45 51 30 1311.4IGF1, INSR, INS, IGF2, LEP
37cycloheximide458.3LEP, IGF2, INSR, IGF1, SLC2A3
38phosphatidylinositol458.3IGF2, LEP, INSR, INS, IGF1
39acth458.2IGF1, IGF2, INS, LEP, OXT
40gnrh458.2OXT, INS, IGF2, IGF1, LEP
41glutamate458.1INSR, IGF2, INS, LEP, OXT
42progesterone45 30 61 26 1312.0IGF2, LEP, OXT, SLC2A3, IGF1
43thyroxine45 268.7LEP, OXT, INSR, INS, IGF2, IGF1
44creatinine457.7INSR, IGF2, IGF1, LEP, OXT, INS
45testosterone45 61 26 1310.7IGF1, IGF2, INS, INSR, LEP, OXT
46arginine457.7LEP, OXT, IGF2, INSR, IGF1, INS
47glucose457.7IGF2, INSR, LEP, PGM1, INS, SLC2A3
48estrogen457.6IGF2, OXT, INS, INSR, LEP, IGF1
49vegf457.6IGF1, OXT, SLC2A3, LEP, INSR, IGF2
50serine457.5IGF2, OXT, LEP, INSR, IGF1, INS

GO Terms for genes affiliated with Fetal Macrosomia

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Cellular components related to Fetal Macrosomia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.5IGF2, IGF1
2extracellular spaceGO:00056157.7OXT, LEP, INS, IGF2, IGF1
3extracellular regionGO:00055767.5IGF1, IGF2, INS, LEP, OXT

Biological processes related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of developmental growthGO:00486399.8LEP, INSR
2positive regulation of respiratory burstGO:00602679.7INS, INSR
3bone mineralization involved in bone maturationGO:00356309.7LEP, IGF1
4activation of protein kinase B activityGO:00321489.7INS, INSR
5positive regulation of activated T cell proliferationGO:00421049.7IGF2, IGF1
6positive regulation of nitric oxide biosynthetic processGO:00454299.6INSR, INS
7positive regulation of insulin receptor signaling pathwayGO:00466289.6IGF2, INS, LEP
8eating behaviorGO:00427559.4OXT, LEP
9insulin receptor signaling pathwayGO:00082869.3INSR, INS, IGF2
10exocrine pancreas developmentGO:00310179.3IGF1, IGF2, INSR
11positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.3INS, IGF1
12positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.3IGF1, IGF2, INS
13memoryGO:00076139.3OXT, IGF2
14response to estradiolGO:00323559.3OXT, IGF2
15glucose metabolic processGO:00060069.2IGF2, INS, LEP, PGM1
16positive regulation of glycolytic processGO:00458219.2INSR, INS, IGF1
17glucose transportGO:00157589.2SLC2A3, INS
18positive regulation of glucose importGO:00463269.2IGF1, INS, INSR
19positive regulation of DNA replicationGO:00457409.2INSR, INS, IGF1
20carbohydrate metabolic processGO:00059759.2INSR, PGM1, SLC2A3
21female pregnancyGO:00075659.1OXT, LEP, IGF2
22positive regulation of glycogen biosynthetic processGO:00457258.9IGF1, IGF2, INS, INSR
23positive regulation of mitosisGO:00458408.9INSR, INS, IGF2, IGF1
24positive regulation of protein kinase B signalingGO:00518978.8IGF1, IGF2, INS, INSR
25positive regulation of MAPK cascadeGO:00434108.5LEP, INSR, INS, IGF2, IGF1
26positive regulation of cell proliferationGO:00082848.4LEP, INSR, INS, IGF2, IGF1

Molecular functions related to Fetal Macrosomia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.1LEP, IGF2, IGF1
2insulin receptor bindingGO:00051588.7INS, IGF2, IGF1
3hormone activityGO:00051798.5IGF1, IGF2, INS, LEP
4insulin-like growth factor receptor bindingGO:00051598.5INSR, INS, IGF2, IGF1

Products for genes affiliated with Fetal Macrosomia

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Sources for Fetal Macrosomia

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet