MCID: FTL021
MIFTS: 45

Fetal Macrosomia malady

Rare diseases category
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Summaries for Fetal Macrosomia

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Wikipedia:65 Large for gestational age (LGA) is an indication of high prenatal growth rate. more...

MalaCards based summary: Fetal Macrosomia is related to hyperinsulinemic hypoglycemia and protein-energy malnutrition. An important gene associated with Fetal Macrosomia is PGM1 (phosphoglucomutase 1), and among its related pathways are HIF-1-alpha transcription factor network and AMPK signaling. The compounds poly(glu(80)tyr(20)) and chromium picolinate have been mentioned in the context of this disorder. Affiliated tissues include testes and placenta, and related mouse phenotypes are liver/biliary system and respiratory system.

Aliases & Classifications for Fetal Macrosomia

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Sources:
42NIH Rare Diseases, 44Novoseek, 62UMLS
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Fetal Macrosomia, Aliases & Descriptions:

Name: Fetal Macrosomia 42 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Fetal Macrosomia

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Diseases related to Fetal Macrosomia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1hyperinsulinemic hypoglycemia30.7INS
2protein-energy malnutrition30.4IGF1, LEP
3gestational diabetes30.3INS, OXT, INSR, SLC2A3, LEP
4diabetes mellitus29.9INSR, INS, IGF1, LEP, SLC2A3
5obesity29.8SLC2A3, INS, LEP, INSR, IGF1
6hypertension29.6IGF1, INS, LEP, INSR
7hypoglycemia29.4IGF2, IGF1, INSR, OXT, SLC2A3, INS
8hyperinsulinism29.4INS, LEP, IGF2, INSR, IGF1
9insulin resistance29.0SLC2A3, INSR, INS, IGF2, LEP, IGF1
10acquired generalized lipodystrophy10.4LEP
11hemihypertrophy10.4IGF2
12laron syndrome10.3IGF2, IGF1
13vaginitis10.3
14insulin-like growth factor 1 resistance to10.2IGF2, IGF1
15hypoglycemic coma10.2INS, IGF2
16familial partial lipodystrophy10.2LEP, INS
17pituitary gland disease10.1INS, IGF1
18eating disorder10.1INS, LEP
19precocious puberty10.1LEP, IGF1
20morbid obesity10.1LEP, INS
21polyhydramnios10.1
22hypoxia10.1
23donohue syndrome10.1INS, INSR
24uterine fibroid10.1IGF2, OXT, IGF1
25fatty liver disease10.1LEP, INS
26anorexia nervosa10.1LEP, OXT, IGF1
27cushing's syndrome10.0IGF1, LEP
28anovulation10.0INS, IGF1, LEP
29amenorrhea10.0LEP, IGF1, INS
30hypopituitarism10.0IGF1, INS, LEP
31hypogonadism10.0IGF1, LEP, INS
32galactosemia10.0IGF1, LEP, INS
33congenital heart disease10.0INS, IGF1, LEP
34hepatoblastoma9.9IGF2, INSR
35congenital generalized lipodystrophy type 29.9INS, INSR, LEP
36lipodystrophy9.9LEP, INSR, INS
37rabson-mendenhall syndrome9.9INSR, IGF1, INS
38insulinoma9.9IGF2, INSR, INS
39uremia9.9INSR, IGF1, LEP
40prader-willi syndrome9.9OXT, IGF1, INS, LEP
41hypertriglyceridemia9.9INS, INSR, LEP
42hypothyroidism9.8IGF1, OXT, LEP, INS
43pre-eclampsia9.8LEP, INSR, OXT
44choriocarcinoma9.8SLC2A3, OXT, IGF2, LEP
45growth hormone deficiency9.8IGF1, IGF2, INS, LEP
46acromegaly9.8IGF1, IGF2, LEP, INS
47short stature9.8INS, LEP, IGF2, IGF1
48diabetic retinopathy9.8IGF1, INS, INSR
49essential hypertension9.8LEP, INSR, INS
50endometrial carcinoma9.8IGF2, IGF1, INSR

Graphical network of the top 20 diseases related to Fetal Macrosomia:



Diseases related to fetal macrosomia

Symptoms for Fetal Macrosomia

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Drugs & Therapeutics for Fetal Macrosomia

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Drug clinical trials:

Search ClinicalTrials for Fetal Macrosomia

Search NIH Clinical Center for Fetal Macrosomia

Genetic Tests for Fetal Macrosomia

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Anatomical Context for Fetal Macrosomia

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MalaCards organs/tissues related to Fetal Macrosomia:

32
Testes, Placenta

Animal Models for Fetal Macrosomia or affiliated genes

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Publications for Fetal Macrosomia

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Articles related to Fetal Macrosomia:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Third trimester insulin levels are not correlated with fetal macrosomia or delivery complications. (24937972)
2014
2
Physical activity, sedentary behaviour and fetal macrosomia in uncomplicated pregnancies: A prospective cohort study. (24861673)
2014
3
Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes. (25231897)
2014
4
Adverse maternal outcomes associated with fetal macrosomia: what are the risk factors beyond birthweight? (23565692)
2013
5
Women's perceptions and experiences of fetal macrosomia. (23786991)
2013
6
The role of umbilical cord thickness and HbA1c levels for the prediction of fetal macrosomia in patients with gestational diabetes mellitus. (21837429)
2012
7
A new formula for optimized weight estimation in extreme fetal macrosomia (a8Y 4500a88g). (22723038)
2012
8
Metformin is not significantly different from insulin for preventing fetal macrosomia in women with gestational diabetes. (21937503)
2012
9
Prediction of fetal macrosomia with ultrasound parameters and maternal glycemic controls in gestational diabetes mellitus. (23444756)
2012
10
Fetal and maternal outcomes in pregnancies complicated with fetal macrosomia. (22754881)
2012
11
Sonographic prediction of fetal macrosomia: the consequences of false diagnosis. (20103792)
2010
12
Fetal macrosomia in non-diabetic mothers: antenatal diagnosis and delivery outcome. (19358025)
2009
13
Risk factors of fetal macrosomia: role of maternal nutrition. (20180374)
2009
14
Fetal macrosomia in African women: a study of 249 cases. (19018549)
2009
15
Fetal macrosomia in pregnant women with gestational diabetes. (20102057)
2009
16
Fetal macrosomia and pregnancy outcomes. (19780734)
2009
17
Fetal macrosomia greater than or equal to 4000 grams. Comparing maternal and neonatal outcomes in diabetic and non-diabetic women. (19370296)
2009
18
Detection of pregnancies with high risk of fetal macrosomia among women with gestational diabetes mellitus. (18728914)
2008
19
Fetal weight estimation for prediction of fetal macrosomia: does additional clinical and demographic data using pattern recognition algorithm improve detection? (22439018)
2008
20
Etiology, detection, and management of fetal macrosomia in pregnancies complicated by diabetes mellitus. (17982341)
2007
21
Treatment of suspected fetal macrosomia: a cost-effectiveness analysis. (17346515)
2007
22
Intrapartum fetal abdominal circumference by ultrasonography for predicting fetal macrosomia. (17726811)
2006
23
2004 Shanghai international workshop of fetal macrosomia and adult obesity. (16100630)
2005
24
Fetal macrosomia. Risk factor and outcome. (15756361)
2005
25
Incidence of fetal macrosomia and birth complications in Chinese immigrant women. (12755347)
2003
26
Effect of fetal macrosomia on human placental glucose transport and utilization in insulin-treated gestational diabetes. (14711103)
2003
27
Fetal macrosomia (> or =4500 g): perinatal outcome of 231 cases according to the mode of delivery. (12673264)
2003
28
The amniotic fluid index as a predictor of fetal macrosomia in a Turkish population. (12706284)
2003
29
Maternal obesity not maternal glucose values correlates best with high rates of fetal macrosomia in pregnancies complicated by gestational diabetes. (12235720)
2002
30
Perinatal and maternal outcomes of fetal macrosomia. (11788165)
2001
31
Effects of a policy of elective cesarean delivery in cases of suspected fetal macrosomia on the incidence of brachial plexus injury and the rate of cesarean delivery. (11084580)
2000
32
Maternal complications of fetal macrosomia. (10863631)
2000
33
Fetal macrosomia related to maternal poorly controlled type 1 diabetes strongly impairs serum lipoprotein concentrations and composition. (11265176)
2000
34
Prophylactic cesarean delivery for fetal macrosomia diagnosed by means of ultrasonography--A Faustian bargain? (10454678)
1999
35
Are conventional targets for metabolic control sufficient to prevent fetal macrosomia during diabetic pregnancy? (10566124)
1999
36
Screening efficacy of the subcutaneous tissue width/femur length ratio for fetal macrosomia in the non-diabetic pregnancy. (10380299)
1999
37
Labor induction with a prenatal diagnosis of fetal macrosomia. (9086425)
1997
38
Prediction of fetal macrosomia using sonographically measured abdominal subcutaneous tissue thickness. (9282803)
1997
39
On the association between maternal phosphoglucomutase 1 (PGM1) and fetal macrosomia in diabetic pregnancy. (8863716)
1996
40
Diabetes in pregnancy: fetal macrosomia, hyperinsulinism, and islet hyperplasia in the offspring of rats subjected to temporary protein-energy malnutrition early in life. (8108195)
1993
41
Fetal macrosomia and gestational diabetes: what's the problem? (8469471)
1993
42
Diabetic fetal macrosomia: significance of disproportionate growth. (8419598)
1993
43
Maternal insulin to lower the risk of fetal macrosomia in diabetic pregnancy. (1868636)
1991
44
Transplacental passage of insulin in pregnant women with insulin-dependent diabetes mellitus. Its role in fetal macrosomia. (2195347)
1990
45
Fetal macrosomia: demographic analysis and perinatal performance in a Chinese population. (3493762)
1986
46
Fetal macrosomia in experimental maternal diabetes. (7457516)
1981
47
Fetal macrosomia in diabetic multiparous animals. (7227701)
1981
48
Serial ultrasonography to assess evolving fetal macrosomia. Studies in 23 pregnant diabetic women. (7373818)
1980
49
Fetal macrosomia--animal models. (6771112)
1980
50
Shoulder dystocia. A complication of fetal macrosomia and prolonged second stage of labor with midpelvic delivery. (724169)
1978

Variations for Fetal Macrosomia

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Expression for genes affiliated with Fetal Macrosomia

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Expression patterns in normal tissues for genes affiliated with Fetal Macrosomia

Search GEO for disease gene expression data for Fetal Macrosomia.

Pathways for genes affiliated with Fetal Macrosomia

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Pathways related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7LEP, PGM1
29.5INSR, LEP
3
Show member pathways
Insulin Pathway37
9.5INS, INSR
49.5INSR, INS
5
Show member pathways
9.5INSR, INS
69.5INSR, INS
79.5INSR, INS
89.5INSR, INS
99.5SLC2A3, INS
109.5IGF1, IGF2
119.5IGF2, IGF1
12
Show member pathways
9.1INS, INSR, LEP
139.1LEP, INSR, INS
14
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.1LEP, INSR, INS
159.1INS, INSR, LEP
16
Show member pathways
9.1LEP, INSR, INS
179.0IGF1, IGF2, INS
18
Show member pathways
9.0LEP, INS, IGF1
199.0LEP, INS, IGF1
20
Show member pathways
9.0INSR, IGF2, IGF1
21
Show member pathways
9.0INSR, IGF2, IGF1
22
Show member pathways
9.0INSR, IGF2, IGF1
23
Show member pathways
9.0IGF1, IGF2, INSR
248.9INSR, INS, IGF1
25
Show member pathways
8.9INSR, INS, IGF1
268.9IGF1, INS, INSR
278.9IGF1, INS, INSR
28
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.9IGF1, INS, INSR
298.9IGF1, INS, INSR
30
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
8.9IGF1, INS, INSR
31
Show member pathways
8.6LEP, INS, IGF2, IGF1
32
Show member pathways
8.5INSR, INS, IGF2, IGF1
33
Show member pathways
8.5IGF1, IGF2, INS, INSR
34
Show member pathways
8.5IGF1, IGF2, INS, INSR
35
Show member pathways
8.5IGF1, IGF2, INS, INSR
36
Show member pathways
7.3IGF1, IGF2, INS, INSR, LEP, OXT

Compounds for genes affiliated with Fetal Macrosomia

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Compounds related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1poly(glu(80)tyr(20))449.8INS, INSR
2chromium picolinate449.5INS, INSR
3cetrorelix44 28 1111.4LEP, IGF1, IGF2
4megestrol acetate449.4LEP, IGF2, IGF1
5ag 1024449.4INSR, IGF1, IGF2
6acipimox44 2810.3LEP, INS, IGF1
72,4-dinitrophenol449.3SLC2A3, IGF2, IGF1
8cortisone44 2410.3INS, IGF1, LEP
9mecasermin44 1110.3INSR, IGF1, INS
10fenofibrate44 50 1111.2LEP, INSR, INS
11insulin (human) recombinant619.2IGF1, INSR
12clomiphene citrate449.2IGF1, INSR, INS
13glibenclamide44 28 50 6112.2LEP, INSR, INS
14pioglitazone28 44 50 1112.1INS, LEP, INSR, IGF2
15l-nmma449.1IGF1, LEP, INSR
16dehydroepiandrosterone sulfate449.0IGF2, INS, IGF1, LEP
17picropodophyllotoxin619.0IGF1, INSR
18dhea449.0LEP, INS, IGF2, IGF1
19androstenedione44 2410.0INS, LEP, IGF1, IGF2
20octreotide44 61 28 1111.9INSR, IGF2, IGF1, INS
21aicar44 24 1110.9IGF1, LEP, INS, INSR
22streptozotocin448.9INS, INSR, OXT
23dihydrotestosterone44 28 24 1111.9IGF1, IGF2, INSR, LEP
24metformin44 50 1110.9LEP, INS, IGF1, INSR
25hydrocortisone44 2 61 1111.9IGF1, IGF2, INS, INSR
26ibmx44 61 2810.9INSR, IGF1, INS, IGF2
27ascorbic acid44 249.6OXT, LEP, SLC2A3, IGF2
28epinephrine44 24 1110.5INS, INSR, LEP, OXT
29c-peptide448.5LEP, INSR, IGF2, INS, IGF1
30progestin448.5OXT, IGF2, IGF1, INSR
31rapamycin448.5IGF1, IGF2, INS, LEP, INSR
32norepinephrine44 24 1110.5IGF2, OXT, LEP, INS
33ly294002448.5IGF1, INSR, INS, IGF2, LEP
34wortmannin448.5INSR, IGF1, INS, LEP
352-deoxyglucose44 119.4INS, IGF2, IGF1, INSR, SLC2A3
36dexamethasone44 50 28 1111.4IGF1, INSR, INS, IGF2, LEP
37cycloheximide448.3LEP, IGF2, INSR, IGF1, SLC2A3
38phosphatidylinositol448.3IGF2, LEP, INSR, INS, IGF1
39acth448.2IGF1, IGF2, INS, LEP, OXT
40gnrh448.2OXT, INS, IGF2, IGF1, LEP
41glutamate448.1INS, IGF2, LEP, OXT, INSR
42progesterone44 28 61 24 1112.0IGF2, LEP, OXT, SLC2A3, IGF1
43thyroxine44 248.7LEP, OXT, INSR, INS, IGF2, IGF1
44creatinine447.7INSR, IGF2, IGF1, LEP, OXT, INS
45testosterone44 61 24 1110.7IGF1, IGF2, INS, INSR, LEP, OXT
46arginine447.7LEP, OXT, IGF2, INSR, IGF1, INS
47glucose447.7IGF2, INSR, LEP, PGM1, INS, SLC2A3
48estrogen447.6OXT, IGF2, INS, INSR, LEP, IGF1
49vegf447.6IGF1, OXT, SLC2A3, LEP, INSR, IGF2
50serine447.5IGF2, OXT, LEP, INSR, IGF1, INS

GO Terms for genes affiliated with Fetal Macrosomia

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Cellular components related to Fetal Macrosomia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5IGF2, IGF1
2extracellular spaceGO:0056157.7OXT, LEP, INS, IGF2, IGF1
3extracellular regionGO:0055767.5IGF1, IGF2, INS, LEP, OXT

Biological processes related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of developmental growthGO:0486399.8LEP, INSR
2positive regulation of respiratory burstGO:0602679.7INS, INSR
3bone mineralization involved in bone maturationGO:0356309.7LEP, IGF1
4activation of protein kinase B activityGO:0321489.7INS, INSR
5positive regulation of activated T cell proliferationGO:0421049.7IGF2, IGF1
6positive regulation of nitric oxide biosynthetic processGO:0454299.6INSR, INS
7positive regulation of insulin receptor signaling pathwayGO:0466289.6IGF2, INS, LEP
8eating behaviorGO:0427559.4OXT, LEP
9insulin receptor signaling pathwayGO:0082869.3INSR, INS, IGF2
10exocrine pancreas developmentGO:0310179.3IGF1, IGF2, INSR
11positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.3INS, IGF1
12positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.3IGF1, IGF2, INS
13memoryGO:0076139.3OXT, IGF2
14response to estradiolGO:0323559.3OXT, IGF2
15glucose metabolic processGO:0060069.2IGF2, INS, LEP, PGM1
16positive regulation of glycolytic processGO:0458219.2INSR, INS, IGF1
17glucose transportGO:0157589.2SLC2A3, INS
18positive regulation of glucose importGO:0463269.2IGF1, INS, INSR
19positive regulation of DNA replicationGO:0457409.2INSR, INS, IGF1
20carbohydrate metabolic processGO:0059759.2INSR, PGM1, SLC2A3
21female pregnancyGO:0075659.1OXT, LEP, IGF2
22positive regulation of glycogen biosynthetic processGO:0457258.9IGF1, IGF2, INS, INSR
23positive regulation of mitosisGO:0458408.9INSR, INS, IGF2, IGF1
24positive regulation of protein kinase B signalingGO:0518978.8IGF1, IGF2, INS, INSR
25positive regulation of MAPK cascadeGO:0434108.5LEP, INSR, INS, IGF2, IGF1
26positive regulation of cell proliferationGO:0082848.4LEP, INSR, INS, IGF2, IGF1

Molecular functions related to Fetal Macrosomia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.1LEP, IGF2, IGF1
2insulin receptor bindingGO:0051588.7INS, IGF2, IGF1
3hormone activityGO:0051798.5IGF1, IGF2, INS, LEP
4insulin-like growth factor receptor bindingGO:0051598.5INSR, INS, IGF2, IGF1

Products for genes affiliated with Fetal Macrosomia

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Sources for Fetal Macrosomia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet