MCID: FTL021
MIFTS: 32

Fetal Macrosomia malady

Summaries for Fetal Macrosomia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Large for gestational age (LGA) is an indication of high prenatal growth rate. LGA is often defined as a... more...

MalaCards: Fetal Macrosomia is related to gestational diabetes and diabetes mellitus. An important gene associated with Fetal Macrosomia is PGM1 (phosphoglucomutase 1), and among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The compounds dehydroepiandrosterone sulfate and cycloheximide have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Fetal Macrosomia

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Sources:
42NIH Rare Diseases, 44Novoseek, 60UMLS
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Aliases & Descriptions:

fetal macrosomia 42 44 60


Related Diseases for Fetal Macrosomia

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17GeneCards, 18GeneDecks
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Diseases related to Fetal Macrosomia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1gestational diabetes30.9OXT, INS, INSR, LEP, SLC2A3
2diabetes mellitus30.7IGF1, GLS2, INS, INSR, LEP, SLC2A3
3obesity30.5IGF1, INS, INSR, LEP, SLC2A3
4hypoglycemia30.2IGF2, IGF1, OXT, GLS2, INS, INSR
5protein-energy malnutrition30.0LEP, IGF1
6hypertension30.0LEP, INSR, INS, IGF1
7hyperinsulinism30.0IGF2, IGF1, INS, INSR, LEP
8vaginitis10.2
9polyhydramnios10.1
10diabetes insipidus10.0OXT
11histiocytosis10.0PGM1
12sarcoma10.0IGF2
13bulimia nervosa10.0LEP
14acquired generalized lipodystrophy10.0LEP
15rhabdomyosarcoma10.0IGF2
16cushing's syndrome10.0INS
17hemihypertrophy10.0IGF2
18blindness10.0INS
19leiomyosarcoma10.0IGF2
20turner syndrome10.0IGF1
21lung cancer10.0IGF1
22pancreatitis10.0INS
23lactic acidosis10.0INS
24craniopharyngioma10.0IGF1
25sheehan syndrome10.0IGF1
26proliferative diabetic retinopathy10.0IGF1
27gigantism10.0IGF1
28neonatal diabetes mellitus10.0INS
29cystic fibrosis10.0INS
30panhypopituitarism10.0IGF1
31ischemia10.0INSR
32myotonic dystrophy10.0INSR
33arthritis10.0LEP
34myoma10.0OXT
35dementia10.0INSR
36infertility10.0INS, LEP
37adenocarcinoma10.0INSR
38hypoglycemic coma10.0INS, IGF2
39adrenal adenoma10.0IGF2
40coronary heart disease10.0INS, LEP
41laron syndrome10.0IGF1, IGF2
42hyperinsulinemic hypoglycemia10.0INS, IGF2
43werner syndrome10.0INSR
44familial partial lipodystrophy10.0LEP, INS
45eating disorder10.0LEP, INS
46insulin-like growth factor 1 resistance to10.0IGF1, IGF2
47myopathy10.0INS, IGF1
48melanoma10.0INSR
49meningioma10.0SLC2A3, IGF2
50glioblastoma multiforme10.0OXT, SLC2A3

Graphical network of the top 20 diseases related to Fetal Macrosomia:



Diseases related to fetal macrosomia

Clinical Features for Fetal Macrosomia

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Drugs & Therapeutics for Fetal Macrosomia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Fetal Macrosomia

Drug clinical trials:

Search ClinicalTrials for Fetal Macrosomia

Search NIH Clinical Center for Fetal Macrosomia

Search CenterWatch for Fetal Macrosomia

Genetic Tests for Fetal Macrosomia

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Anatomical Context for Fetal Macrosomia

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Animal Models for Fetal Macrosomia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Fetal Macrosomia:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.1OXT
2MP:00107719.1INS, OXT, IGF2
3MP:00053698.4IGF2, IGF1, INS, INSR, LEP
4MP:00053818.3IGF2, OXT, INS, INSR, LEP
5MP:00053797.9IGF2, IGF1, OXT, INS, INSR, LEP
6MP:00053857.9IGF2, IGF1, OXT, INS, INSR, LEP
7MP:00053897.5SLC2A3, IGF2, IGF1, OXT, INS, INSR
8MP:00053867.4IGF2, OXT, INS, INSR, LEP, SLC2A3
9MP:00036317.4IGF2, IGF1, OXT, INS, INSR, LEP
10MP:00053767.3IGF2, IGF1, OXT, INS, INSR, LEP
11MP:00107687.1IGF2, IGF1, OXT, INS, INSR, LEP

Publications for Fetal Macrosomia

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Genetic Variations for Fetal Macrosomia

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Expression for genes affiliated with Fetal Macrosomia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fetal Macrosomia

Search GEO for disease gene expression data for Fetal Macrosomia.

Pathways for genes affiliated with Fetal Macrosomia

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Sources:
51QIAGEN, 52R&D Systems, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Pathways related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.0INSR
2
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10.0INSR
3
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9.7LEP, INS
49.6INSR, INS
5
Transcription Transcription factor Tubby signaling pathways
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9.6INSR, INS
69.6INS, INSR
7
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9.6INSR, INS
89.6IGF1, IGF2
99.2INS, INSR, LEP
109.2INS, INSR, LEP
119.2INS, INSR, LEP
129.2INS, IGF1, IGF2
139.2LEP, INS, IGF1
149.1INSR, INS, IGF1
159.1IGF1, INS, INSR
169.1IGF1, INS, INSR
17
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8.7IGF2, IGF1, INS, INSR
18
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8.7INSR, INS, IGF1, IGF2
19
Hide members
8.7INSR, INS, IGF1, IGF2
20
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8.7IGF2, IGF1, INS, INSR

Compounds for genes affiliated with Fetal Macrosomia

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1dehydroepiandrosterone sulfate4410.6IGF2
2cycloheximide4410.2SLC2A3
3glutamate4410.0GLS2
42,4-dinitrophenol4410.0IGF2, SLC2A3
5poly(glu(80)tyr(20))449.9INSR, INS
6insulin (human) recombinant599.7INSR, IGF1
7bms 536924599.6IGF1, INSR
8cetrorelix44 28 1111.6IGF2, IGF1, LEP
9megestrol acetate449.6LEP, IGF1, IGF2
10demethylasterriquinone b1599.6IGF1, INSR
11chromium picolinate449.6INS, INSR
12ag 1024449.6INSR, IGF1, IGF2
13picropodophyllotoxin599.6IGF1, INSR
14acipimox44 2810.5IGF1, INS, LEP
15mecasermin44 1110.5INS, INSR, IGF1
16cortisone44 2410.5LEP, INS, IGF1
17clomiphene citrate449.4INSR, IGF1, INS
18fenofibrate44 49 1111.4INSR, LEP, INS
19l-nmma449.3INSR, LEP, IGF1
20pioglitazone44 49 28 1112.3INS, INSR, LEP, IGF2
21dexamethasone44 49 28 1112.3INS, INSR, IGF2
22dhea449.2IGF2, IGF1, LEP, INS
23streptozotocin449.2OXT, INSR, INS
24androstenedione44 2410.2IGF2, LEP, INS, IGF1
25octreotide44 59 28 1112.2IGF2, INSR, INS, IGF1
26aicar44 11 2411.2INSR, IGF1, INS, LEP
27metformin44 49 1111.1INS, INSR, IGF1, LEP
28dihydrotestosterone44 28 11 2412.1INSR, IGF2, IGF1, LEP
29hydrocortisone44 2 59 1112.1INSR, INS, IGF1, IGF2
30ibmx44 28 5911.1IGF2, INS, INSR, IGF1
31glibenclamide44 28 49 5911.9INS, INSR, LEP
32progestin448.9IGF2, IGF1, OXT, INSR
33epinephrine44 11 2410.9INS, INSR, LEP, OXT
34c-peptide448.8INS, INSR, LEP, IGF1, IGF2
35rapamycin448.8IGF2, IGF1, INS, INSR, LEP
36ly294002448.7IGF2, IGF1, INS, INSR, LEP
372-deoxyglucose44 119.7INS, IGF2, INSR, SLC2A3, IGF1
38acth448.6INS, LEP, OXT, IGF2, IGF1
39ascorbic acid44 249.5LEP, OXT, SLC2A3, IGF2
40gaba448.5INSR, LEP, GLS2, OXT
41glucose448.5PGM1, GLS2, IGF2, INSR, IGF1
42progesterone44 59 28 11 2412.4OXT, LEP, SLC2A3, IGF1, IGF2
43glycogen44 249.3IGF2, INS, INSR, SLC2A3, GLS2
44thyroxine44 249.2IGF2, INSR, LEP, IGF1, INS, OXT
45creatinine448.2OXT, IGF2, IGF1, LEP, INSR, INS
46testosterone44 59 11 2411.2INS, IGF1, IGF2, INSR, OXT, LEP
47estrogen448.1LEP, INSR, OXT, IGF1, INS, IGF2
48glutamine448.0INSR, OXT, IGF1, IGF2, GLS2
49vegf448.0IGF2, SLC2A3, IGF1, OXT, INSR, LEP
50arginine447.4LEP, INSR, INS, GLS2, OXT, IGF1

GO Terms for genes affiliated with Fetal Macrosomia

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16Gene Ontology
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Cellular components related to Fetal Macrosomia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2IGF1, OXT, INS, LEP, IGF2
2extracellular spaceGO:0056157.9LEP, INS, OXT, IGF1, IGF2

Biological processes related to Fetal Macrosomia according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of developmental growthGO:0486399.9LEP, INSR
2positive regulation of respiratory burstGO:0602679.8INSR, INS
3bone mineralization involved in bone maturationGO:0356309.8LEP, IGF1
4positive regulation of insulin receptor signaling pathwayGO:0466289.7IGF2, INS, LEP
5exocrine pancreas developmentGO:0310179.6INSR, IGF1
6activation of protein kinase B activityGO:0321489.6INS, INSR
7positive regulation of nitric oxide biosynthetic processGO:0454299.6INSR, INS
8positive regulation of activated T cell proliferationGO:0421049.5IGF1, IGF2
9positive regulation of glycolysisGO:0458219.4IGF1, INS, INSR
10positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.3IGF2, IGF1, INS
11positive regulation of glucose importGO:0463269.3INSR, INS, IGF1
12insulin receptor signaling pathwayGO:0082869.3INSR, INS, IGF2
13positive regulation of DNA replicationGO:0457409.3IGF1, INS, INSR
14glucose metabolic processGO:0060069.3LEP, PGM1, INS, IGF2
15eating behaviorGO:0427559.2LEP, OXT
16positive regulation of glycogen biosynthetic processGO:0457259.1IGF2, IGF1, INS, INSR
17positive regulation of mitosisGO:0458409.1INSR, INS, IGF1, IGF2
18positive regulation of protein kinase B signaling cascadeGO:0518979.0INSR, INS, IGF1, IGF2
19positive regulation of MAPK cascadeGO:0434108.7LEP, INSR, INS, IGF1, IGF2
20positive regulation of cell proliferationGO:0082848.6IGF2, IGF1, INS, INSR, LEP

Molecular functions related to Fetal Macrosomia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.2LEP, IGF1, IGF2
2insulin receptor bindingGO:0051588.9INS, IGF1, IGF2
3insulin-like growth factor receptor bindingGO:0051598.7INSR, INS, IGF1, IGF2
4hormone activityGO:0051798.7IGF2, IGF1, INS, LEP

Products for genes affiliated with Fetal Macrosomia

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Sources for Fetal Macrosomia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet