MCID: FTL021
MIFTS: 46

Fetal Macrosomia

Categories: Rare diseases, Fetal diseases

Aliases & Classifications for Fetal Macrosomia

MalaCards integrated aliases for Fetal Macrosomia:

Name: Fetal Macrosomia 49 51 69

Classifications:



External Ids:

UMLS 69 C0015938

Summaries for Fetal Macrosomia

MalaCards based summary : Fetal Macrosomia is related to gestational diabetes and diabetes mellitus. An important gene associated with Fetal Macrosomia is INS (Insulin), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and AMP-activated Protein Kinase (AMPK) Signaling. The drugs Glyburide and Zinc have been mentioned in the context of this disorder. Affiliated tissues include fetal lung, testes and ovary, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Fetal Macrosomia

Diseases related to Fetal Macrosomia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 gestational diabetes 30.5 INS INSR LEP
2 diabetes mellitus 29.8 IGF1 INS INSR LEP
3 insulin-like growth factor i 28.6 IGF1 IGF2 IGFBP3 INS INSR LEP
4 hyperinsulinism 28.4 APOB IGF1 IGFBP3 INS INSR LEP
5 body mass index quantitative trait locus 11 28.1 APOA1 APOB IGF1 IGFBP3 INS INSR
6 perlman syndrome 11.3
7 apo a-i deficiency 10.5 APOA1 LCAT
8 hypoglycemic coma 10.5 IGF2 INS
9 type 1 diabetes mellitus 2 10.5 IGF2 INS
10 insulin autoimmune syndrome 10.5 INS INSR
11 familial lcat deficiency 10.5 APOA1 LCAT
12 silver-russell syndrome due to an imprinting defect of 11p15 10.5 H19 IGF2
13 silver-russell syndrome due to 11p15 microduplication 10.5 H19 IGF2
14 beckwith-wiedemann syndrome due to imprinting defect of 11p15 10.5 H19 IGF2
15 slipped capital femoral epiphysis 10.4 IGF1 IGFBP3
16 hyperinsulinemic hypoglycemia, familial, 2 10.4 IGF2 INS
17 fish-eye disease 10.4 APOA1 LCAT
18 hemihyperplasia, isolated 10.4 H19 IGF2
19 pituitary adenoma 1, multiple types 10.4 IGF1 IGFBP3
20 sheehan syndrome 10.4 IGF1 INS
21 pseudopapilledema 10.4 IGF1 IGF2
22 diffuse idiopathic skeletal hyperostosis 10.4 IGF1 IGFBP3
23 defective apolipoprotein b-100 10.3 APOB LCAT
24 rubeosis iridis 10.3 IGF1 IGF2 INS
25 hyperpituitarism 10.3 IGF1 IGFBP3 INS
26 acid-labile subunit deficiency 10.3 IGF1 IGF2 IGFBP3
27 donohue syndrome 10.3 IGF1 INS INSR
28 ocular hyperemia 10.3 IGF2 IGFBP3
29 osteoporosis, juvenile 10.3 IGF1 IGFBP3
30 body mass index quantitative trait locus 9 10.3
31 body mass index quantitative trait locus 8 10.3
32 body mass index quantitative trait locus 4 10.3
33 body mass index quantitative trait locus 10 10.3
34 body mass index quantitative trait locus 7 10.3
35 body mass index quantitative trait locus 12 10.3
36 body mass index quantitative trait locus 14 10.3
37 body mass index quantitative trait locus 18 10.3
38 hypopituitarism 10.3 IGF1 IGFBP3 INS
39 laron syndrome 10.3 IGF1 IGF2 IGFBP3
40 mammographic density 10.3 IGF1 IGFBP3
41 fasting hypoglycemia 10.3 IGF1 IGF2 INSR
42 hyperandrogenism 10.2 IGF1 INS INSR
43 leukodystrophy, hypomyelinating, 3 10.2 APOA1 APOB
44 amyloidosis aa 10.2 APOA1 LCAT
45 hypertriglyceridemia, familial 10.2 APOA1 APOB INS
46 hepatoblastoma 10.2 APOA1 H19 IGF2
47 dysbaric osteonecrosis 10.2 APOA1 APOB
48 lipoprotein glomerulopathy 10.2 APOB LCAT
49 gallbladder disease 10.2 APOA1 APOB INS
50 hypobetalipoproteinemia, familial, 1 10.2 APOA1 APOB LCAT

Graphical network of the top 20 diseases related to Fetal Macrosomia:



Diseases related to Fetal Macrosomia

Symptoms & Phenotypes for Fetal Macrosomia

MGI Mouse Phenotypes related to Fetal Macrosomia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.15 INSR IGF2 APOA1 IGFBP3 APOB APOM
2 cardiovascular system MP:0005385 10.13 IGF2 LCAT APOA1 IGFBP3 APOB INS
3 endocrine/exocrine gland MP:0005379 10.06 INSR IGF2 APOA1 IGFBP3 INS IGF1
4 adipose tissue MP:0005375 9.93 INSR IGFBP3 INS IGF1 LEP OXT
5 integument MP:0010771 9.87 IGF2 APOA1 IGFBP3 INS IGF1 LEP
6 liver/biliary system MP:0005370 9.86 IGF2 LCAT IGFBP3 APOA1 APOB INS
7 muscle MP:0005369 9.7 INSR IGF2 IGFBP3 APOB INS IGF1
8 renal/urinary system MP:0005367 9.56 IGF2 LCAT IGFBP3 INS IGF1 INSR
9 reproductive system MP:0005389 9.28 INSR IGF2 APOB APOM INS IGF1

Drugs & Therapeutics for Fetal Macrosomia

Drugs for Fetal Macrosomia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glyburide Approved Phase 4,Phase 3,Phase 2 10238-21-8 3488
2
Zinc Approved, Investigational Phase 4,Phase 3 7440-66-6 32051 23994
3
Metformin Approved Phase 4,Phase 2,Phase 3 657-24-9 4091 14219
4 insulin Phase 4,Phase 3,Phase 2
5 Hypoglycemic Agents Phase 4,Phase 2,Phase 3
6 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2
7
Diazoxide Approved Phase 2, Phase 3 364-98-7 3019
8
Acarbose Approved, Investigational Phase 3 56180-94-0 441184
9 Vasodilator Agents Phase 2, Phase 3
10 Antihypertensive Agents Phase 2, Phase 3
11 Insulin, Isophane Phase 3
12 Isophane insulin, beef Phase 3
13 Isophane Insulin, Human Phase 3
14 Glycoside Hydrolase Inhibitors Phase 3
15 Insulin, Short-Acting Phase 3
16 Cardiac Glycosides Phase 3
17 glucagon Phase 2
18 Gastrointestinal Agents Phase 2
19 Glucagon-Like Peptide 1 Phase 2
20 Hormone Antagonists Phase 2
21 Hormones Phase 2,Early Phase 1
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
23 Incretins Phase 2
24
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
25
Epinephrine Approved, Vet_approved 51-43-4 5816
26
Insulin Aspart Approved 116094-23-6 16132418
27 Racepinephrine Approved 329-65-7
28
Menthol Approved 2216-51-5 16666
29
Insulin Lispro Approved 133107-64-9
30
Insulin Glargine Approved 160337-95-1
31
Insulin Detemir Approved 169148-63-4 5311023
32
Zinc oxide Approved 1314-13-2
33
leucovorin Approved, Nutraceutical 58-05-9 143 6006
34 tannic acid Approved, Nutraceutical
35
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
36
Blackberry Approved, Nutraceutical
37
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
38
Cholecalciferol Approved, Nutraceutical 67-97-0 10883523 5280795 6221
39
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
40
Imidacloprid Vet_approved 105827-78-9 86418
41 Micronutrients
42 Mitogens
43 Trace Elements
44 Hematinics
45 Vitamin B Complex
46 Vitamins
47 Calcifediol 19356-17-3
48 Respiratory System Agents
49 Adrenergic Agents
50 Adrenergic Agonists

Interventional clinical trials:

(show top 50) (show all 119)

# Name Status NCT ID Phase Drugs
1 Oral Antidiabetic Agents in Pregnancy Unknown status NCT02091336 Phase 4 Metformin;Glyburide
2 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4 Metformin
3 DAME: Induction of Labor or Waiting for Suspicion Fetal Macrosomia Completed NCT00190320 Phase 4
4 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4 metformin;glybenclamide
5 Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo Completed NCT00744965 Phase 4 Glyburide;Placebo
6 Glyburide Compared to Insulin in the Management of White's Classification A2 Gestational Diabetes Withdrawn NCT00160485 Phase 4 Glyburide;Insulin
7 Diazoxide In the Management Of Hypoglycemic Neonates Unknown status NCT00994149 Phase 2, Phase 3 Diazoxide;Ora-plus
8 Metformin in Obese Non-diabetic Pregnant Women Completed NCT01273584 Phase 2, Phase 3 Metformin;Placebo
9 Multicenter Randomized Trial of Non-inferiority Between Glyburide and Insulin for the Treatment of Gestational Diabetes Completed NCT01731431 Phase 3 Glyburide
10 Comparison of Metformin and Insulin for Management of Gestational Diabetes Mellitus Completed NCT03320694 Phase 3 Metformin;Insulin
11 Metformin in Women With Type 2 Diabetes in Pregnancy Trial Recruiting NCT01353391 Phase 3 Metformin;Placebo Comparator
12 Effect of a Continuous Glucose Monitoring on Maternal and Neonatal Outcomes in Gestational Diabetes Mellitus Not yet recruiting NCT02838147 Phase 3
13 Acarbose and Prandial Insulin for the Treatment of Gestational Diabetes Mellitus. Not yet recruiting NCT03380546 Phase 3 Acarbose;Prandial insulin
14 Pregnancy Outcomes: Effects of Metformin Study (POEM Study) Not yet recruiting NCT02947503 Phase 3 Metformin HCL 850 CF
15 Home Versus Hospital Care in Glucose Monitoring of Gestational Diabetes and Mild Gestational Hyperglycemia Completed NCT01441518 Phase 2
16 Glucagon in the Treatment of Hypoglycemia in Newborn Infants of Diabetic Mothers Completed NCT00434772 Phase 2 glucagon
17 Impact of Diet and Exercise Activity on Pregnancy Outcomes Recruiting NCT00486629 Phase 2
18 Antenatal Development Evaluated Prospectively Unknown status NCT02478554
19 Fish Oil Supplementation in Women With Gestational Diabetes Unknown status NCT02371343
20 Diet and Physical Activity Counseling and n3-long Chain (PUFA) Supplementation in Obese Pregnant Women Unknown status NCT02574767
21 Weight Gain During Pregnancy - a Randomized Controlled Trial of Intervention to Prevent Excessive Gestational Weight Gain Unknown status NCT00451425
22 Predictors of Maternal Weight Gain and Neonatal Body Composition Unknown status NCT00634764
23 Frequency of Blood Glucose Monitoring in Patients With Gestational Diabetes Unknown status NCT01818557
24 Postprandial Walking in Obese Pregnant Women and Perinatal Outcomes - a Multicenter Randomized Clinical Trial Unknown status NCT02180152
25 Effect of Psycho-education on Gestational Weight Gain and Anxiety/Depression in Obese Pregnant Women Unknown status NCT01329835
26 Lipophilic Micronutrients, Adipokines and Gestational Diabetes Mellitus Unknown status NCT01678469
27 Vaspin Levels Compared With Serum Insulin and Blood Glucose Levels in Neonates Unknown status NCT01363622
28 Inositol Stereoisomers to Treat Gestational Diabetes Unknown status NCT02097069
29 Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes Unknown status NCT00678080 Metformin;Insulin (NPH and Regular)
30 Managing Diabetes During Pregnancy in the Wireless Age Unknown status NCT01474525
31 The Role of Umbilical Cord Thickness in Prediction of Fetal Macrosomia in Patients With Gestational Diabetes Mellitus Completed NCT02643225
32 The DNA Methylation of ARHGEF11 in Macrosomia Completed NCT03165643
33 Fetal Front-abdominal Wall Thickness and Perinatal Outcome Completed NCT03232294
34 Breast Milk Zinc Transfer to Appropriate- and Small-for-gestational-age Bangladeshi Infants Completed NCT01728766
35 Treatment of Impaired Glucose Tolerance in Pregnancy Completed NCT00625781 Insulin aspart and Insulin human (isophane)
36 Meal Composition and the Influence on Pre-prandial Blood Glucose Values Completed NCT03028506
37 Correlation Between Placental Thickness in the Second and Third Trimester and Fetal Weight Completed NCT02473991
38 Lifestyle Intervention and Prevention of Gestational Diabetes Mellitus Completed NCT02368600
39 Exploration of the Lipid Metabolism During the Diabetic Pregnancies Completed NCT00639964
40 Randomized Translational Study to Examine the Effects of Shared Care in Management of Gestational Diabetes Completed NCT01565564
41 Weight Management for Improved Pregnancy Outcomes Completed NCT00950235
42 Improve Detection and Management of Gestational Diabetes Through the Primary Health Care Level in Morocco Completed NCT02979756
43 Myo-inositol in Obese Pregnant Women Completed NCT01047982
44 Exercise Training in Pregnancy for Obese Mothers Completed NCT01243554
45 Fructosamines and Gestational Diabetes (FRUCTO) Completed NCT02159378
46 Dietary and Lifestyle Interventions in Obese Pregnant Women Completed NCT02095028
47 Improving Outcomes in Underserved Women With GDM Completed NCT00774124
48 Maternal Obesity and Small for Gestational Age Infants Completed NCT00371657
49 Preventing Childhood Obesity: A Two-pronged Approach Starting in Pregnancy and the First Year Postpartum Completed NCT01129505
50 Fetal Growth Evaluation by Three-Dimensional Ultrasound Completed NCT00340171

Search NIH Clinical Center for Fetal Macrosomia

Genetic Tests for Fetal Macrosomia

Anatomical Context for Fetal Macrosomia

MalaCards organs/tissues related to Fetal Macrosomia:

38
Fetal Lung, Testes, Ovary, Lung, Bone, Placenta

Publications for Fetal Macrosomia

Articles related to Fetal Macrosomia:

(show top 50) (show all 204)
# Title Authors Year
1
Level of maternal triglycerides is a predictor of fetal macrosomia in non-obese pregnant women with gestational diabetes mellitus. ( 29398554 )
2018
2
Frequency of fetal macrosomia and the associated risk factors in pregnancies without gestational diabetes mellitus. ( 28451039 )
2017
3
Induction of labour at 37 weeks for suspected fetal macrosomia may reduce birth trauma. ( 28646127 )
2017
4
Correlation of placental microbiota with fetal macrosomia and clinical characteristics in mothers and newborns. ( 29137266 )
2017
5
Measurement and evaluation of fetal fat layer in the prediction of fetal macrosomia in pregnancies complicated by gestational diabetes. ( 28631075 )
2017
6
Associated outcomes to fetal macrosomia: effect of maternal diabetes. ( 29424871 )
2017
7
Third trimester ultrasound for fetal macrosomia: optimal timing and institutional specific accuracy. ( 29183184 )
2017
8
Morbidity Associated with Fetal Macrosomia among Women with Diabetes Mellitus. ( 29183096 )
2017
9
Vacuum extraction in fetal macrosomia: registry data are useful. ( 28117885 )
2017
10
Potential prognostic biomarkers of cardiovascular disease in fetal macrosomia: the impact of gestational diabetes. ( 28298172 )
2017
11
AN ERUPTION PATTERN OF DECIDUOUS TEETH IN CHILDREN BORN WITH FETAL MACROSOMIA DURING THE FIRST YEAR OF LIFE. ( 28452722 )
2017
12
Amniotic fluid index and estimated fetal weight for prediction of fetal macrosomia: a prospective observational study. ( 27596358 )
2016
13
Gestational diabetes: Glycaemic predictors for fetal macrosomia and maternal risk of future diabetes. ( 26818892 )
2016
14
Practice Bulletin No. 173 Summary: Fetal Macrosomia. ( 27776066 )
2016
15
Peptidome profiling of umbilical cord plasma associated with gestational diabetes-induced fetal macrosomia. ( 26945739 )
2016
16
Fetal macrosomia as a risk factor for shoulder dystocia during vacuum extraction. ( 27549142 )
2016
17
Risk factors and outcomes of fetal macrosomia in a tertiary centre in Tanzania: a case-control study. ( 27557930 )
2016
18
Comparison of 2- and 3-Dimensional Sonography for Estimation of Birth Weight and Neonatal Adiposity in the Setting of Suspected Fetal Macrosomia. ( 27091915 )
2016
19
Induction of labour for suspected fetal macrosomia, Boulvain et al (2016). ( 27652444 )
2016
20
Induction of labour at or near term for suspected fetal macrosomia. ( 27208913 )
2016
21
Vacuum extraction in fetal macrosomia and risk of neonatal complications: a population-based cohort study. ( 27472147 )
2016
22
Practice Bulletin No. 173: Fetal Macrosomia. ( 27776071 )
2016
23
Induction of labour for fetal macrosomia: do we finally have an answer? ( 27921388 )
2016
24
Low cord blood serum levels of vitamin D: cause or effect of fetal macrosomia? ( 26411220 )
2015
25
Does fetal macrosomia affect umbilical artery Doppler velocity waveforms in pregnancies complicated by gestational diabetes? ( 26699801 )
2015
26
Fetal macrosomia: induction of labour or expectant management? - Authors' reply. ( 26595634 )
2015
27
Weight gain in pregnancy, maternal age and gestational age in relation to fetal macrosomia. ( 25954731 )
2015
28
Fetal macrosomia: induction of labour or expectant management? ( 26595636 )
2015
29
Determinants and outcome of fetal macrosomia in a Nigerian tertiary hospital. ( 26903699 )
2015
30
The Effects of Prepregnancy Body Mass Index and Gestational Weight Gain on Fetal Macrosomia Among American Indian/Alaska Native Women. ( 26122253 )
2015
31
Cord blood copeptin concentrations in fetal macrosomia. ( 26477270 )
2015
32
Effect of Personalized Nutrition Guidance on the Birth Rate of Fetal Macrosomia in Chinese Population: A Meta-analysis of Nine Randomized Controlled Trials. ( 27352186 )
2015
33
Fetal macrosomia: induction of labour or expectant management? ( 26595635 )
2015
34
An Evidence-Based Approach to Defining Fetal Macrosomia. ( 26499356 )
2015
35
Fetal macrosomia: induction of labour or expectant management? ( 26595633 )
2015
36
Third trimester insulin levels are not correlated with fetal macrosomia or delivery complications. ( 24937972 )
2014
37
Differential expression of circulating miRNAs in maternal plasma in pregnancies with fetal macrosomia. ( 25370776 )
2014
38
Amniotic fluid insulin and C-peptide as predictive markers for fetal macrosomia, birth injuries, and delivery complications? ( 24423633 )
2014
39
Estimate of fetal weight by ultrasound within two weeks of delivery in the detection of fetal macrosomia. ( 24773582 )
2014
40
The combined effect of maternal obesity and fetal macrosomia on pregnancy outcomes. ( 25222356 )
2014
41
Maternal obesity and occurrence of fetal macrosomia: a systematic review and meta-analysis. ( 25544943 )
2014
42
Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes. ( 25231897 )
2014
43
Sonographic weight estimation in fetal macrosomia: influence of the time interval between estimation and delivery. ( 25534163 )
2014
44
Fetal macrosomia: a problem in need of a policy. ( 24395685 )
2014
45
Physical activity, sedentary behaviour and fetal macrosomia in uncomplicated pregnancies: A prospective cohort study. ( 24861673 )
2014
46
Counseling for Fetal Macrosomia: An Estimated Fetal Weight of 4,000a88g is Excessively Low. ( 24839149 )
2014
47
Increased mRNA levels of apolipoprotein M and apolipoprotein AI in the placental tissues with fetal macrosomia. ( 25194312 )
2014
48
Adverse maternal outcomes associated with fetal macrosomia: what are the risk factors beyond birthweight? ( 23565692 )
2013
49
Fetal macrosomia and shoulder dystocia in women with gestational diabetes: risks amenable to treatment? ( 23076441 )
2013
50
Following the 2009 American Institute of Medicine recommendations for normal body mass index and overweight women led to an increased risk of fetal macrosomia among Taiwanese women. ( 24075370 )
2013

Variations for Fetal Macrosomia

Expression for Fetal Macrosomia

Search GEO for disease gene expression data for Fetal Macrosomia.

Pathways for Fetal Macrosomia

Pathways related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.46 APOA1 APOB APOM SLC2A3
2
Show member pathways
12.15 IGF1 INS INSR LEP
3
Show member pathways
12.04 APOA1 APOB INS INSR
4
Show member pathways
11.92 IGF1 INS INSR
5
Show member pathways
11.84 IGF1 INS INSR
6 11.81 IGF1 INS LEP
7
Show member pathways
11.74 APOA1 APOB LCAT
8 11.68 IGF1 IGFBP3 INS
9 11.63 IGF1 INS INSR
10 11.27 IGF1 IGF2 INS
11 11.24 IGF1 IGFBP3 INS LEP
12 11.2 IGF1 INS INSR
13 11.13 INS INSR LEP
14 10.94 APOA1 APOB
15 10.9 IGF1 INS INSR
16 10.88 INSR LEP
17 10.12 IGF1 IGF2 IGFBP3

GO Terms for Fetal Macrosomia

Cellular components related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.81 APOA1 APOB IGFBP3 INS
2 extracellular region GO:0005576 9.7 APOA1 APOB APOM IGF1 IGF2 IGFBP3
3 endosome lumen GO:0031904 9.55 APOB INS
4 endocytic vesicle lumen GO:0071682 9.54 APOA1 APOB
5 chylomicron GO:0042627 9.52 APOA1 APOB
6 high-density lipoprotein particle GO:0034364 9.5 APOA1 APOM LCAT
7 spherical high-density lipoprotein particle GO:0034366 9.48 APOA1 APOM
8 intermediate-density lipoprotein particle GO:0034363 9.46 APOA1 APOB
9 insulin-like growth factor ternary complex GO:0042567 9.43 IGF1 IGFBP3
10 very-low-density lipoprotein particle GO:0034361 9.43 APOA1 APOB APOM
11 insulin-like growth factor binding protein complex GO:0016942 9.4 IGF1 IGFBP3
12 discoidal high-density lipoprotein particle GO:0034365 9.37 APOA1 APOM
13 low-density lipoprotein particle GO:0034362 9.33 APOA1 APOB APOM
14 extracellular space GO:0005615 9.32 APOA1 APOB APOM IGF1 IGF2 IGFBP3
15 extracellular exosome GO:0070062 10.15 APOA1 APOB APOM IGF2 IGFBP3 INSR

Biological processes related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.92 IGF2 INS INSR PGM1 SLC2A3
2 positive regulation of protein kinase B signaling GO:0051897 9.88 IGF2 INS INSR LEP
3 lipid transport GO:0006869 9.86 APOA1 APOB APOM
4 platelet degranulation GO:0002576 9.86 APOA1 IGF1 IGF2
5 steroid metabolic process GO:0008202 9.85 APOA1 APOB LCAT
6 glucose homeostasis GO:0042593 9.85 INS INSR LEP
7 response to estradiol GO:0032355 9.85 APOB LEP OXT
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.84 IGF1 IGF2 INS
9 insulin receptor signaling pathway GO:0008286 9.83 IGF2 INS INSR
10 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.81 IGF1 INS LEP
11 retinoid metabolic process GO:0001523 9.81 APOA1 APOB APOM
12 cholesterol metabolic process GO:0008203 9.81 APOA1 APOB LCAT LEP
13 positive regulation of DNA replication GO:0045740 9.77 IGF1 INS INSR
14 activation of protein kinase B activity GO:0032148 9.75 IGF1 INS INSR
15 positive regulation of glucose import GO:0046326 9.74 IGF1 INS INSR
16 cholesterol transport GO:0030301 9.73 APOA1 APOB LCAT
17 cholesterol homeostasis GO:0042632 9.73 APOA1 APOB APOM LCAT
18 cellular protein metabolic process GO:0044267 9.73 APOA1 APOB IGF1 IGF2 IGFBP3 INS
19 lipoprotein metabolic process GO:0042157 9.72 APOA1 APOB APOM
20 cholesterol efflux GO:0033344 9.71 APOA1 APOB APOM
21 adrenal gland development GO:0030325 9.68 APOA1 INSR
22 high-density lipoprotein particle assembly GO:0034380 9.67 APOA1 APOM
23 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.67 IGF1 IGFBP3
24 positive regulation of glycolytic process GO:0045821 9.67 IGF1 INS INSR
25 glucose metabolic process GO:0006006 9.67 IGF2 INS LEP PGM1
26 chylomicron assembly GO:0034378 9.66 APOA1 APOB
27 chylomicron remodeling GO:0034371 9.65 APOA1 APOB
28 high-density lipoprotein particle clearance GO:0034384 9.65 APOA1 APOM
29 reverse cholesterol transport GO:0043691 9.65 APOA1 APOM LCAT
30 positive regulation of respiratory burst GO:0060267 9.63 INS INSR
31 high-density lipoprotein particle remodeling GO:0034375 9.63 APOA1 APOM LCAT
32 neuron projection maintenance GO:1990535 9.62 INS INSR
33 positive regulation of developmental growth GO:0048639 9.61 INSR LEP
34 bone mineralization involved in bone maturation GO:0035630 9.61 IGF1 LEP
35 regulation of intestinal cholesterol absorption GO:0030300 9.6 APOA1 LEP
36 positive regulation of insulin receptor signaling pathway GO:0046628 9.58 IGF2 INS LEP
37 lipoprotein biosynthetic process GO:0042158 9.5 APOA1 APOB LCAT
38 positive regulation of mitotic nuclear division GO:0045840 9.46 IGF1 IGF2 INS INSR
39 positive regulation of glycogen biosynthetic process GO:0045725 9.26 IGF1 IGF2 INS INSR
40 positive regulation of MAPK cascade GO:0043410 9.1 IGF1 IGF2 IGFBP3 INS INSR LEP
41 positive regulation of cell proliferation GO:0008284 10.04 IGF1 IGF2 INS INSR LEP
42 regulation of receptor activity GO:0010469 10.02 IGF1 IGF2 INS LEP OXT

Molecular functions related to Fetal Macrosomia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.54 APOA1 APOB APOM
2 cholesterol transporter activity GO:0017127 9.43 APOA1 APOB
3 lipid transporter activity GO:0005319 9.43 APOA1 APOB APOM
4 insulin-like growth factor I binding GO:0031994 9.4 IGFBP3 INSR
5 hormone activity GO:0005179 9.35 IGF1 IGF2 INS LEP OXT
6 insulin receptor binding GO:0005158 9.33 IGF1 IGF2 INS
7 insulin-like growth factor II binding GO:0031995 9.32 IGFBP3 INSR
8 insulin-like growth factor receptor binding GO:0005159 8.92 IGF1 IGF2 INS INSR

Sources for Fetal Macrosomia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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