MCID: FTL021
MIFTS: 41

Fetal Macrosomia malady

Categories: Rare diseases, Fetal diseases

Aliases & Classifications for Fetal Macrosomia

Aliases & Descriptions for Fetal Macrosomia:

Name: Fetal Macrosomia 50 52 69

Classifications:



Summaries for Fetal Macrosomia

MalaCards based summary : Fetal Macrosomia is related to perlman syndrome and gestational diabetes. An important gene associated with Fetal Macrosomia is INS (Insulin), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and AMP-activated Protein Kinase (AMPK) Signaling. The drugs Glyburide and Metformin have been mentioned in the context of this disorder. Affiliated tissues include testes and placenta, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Fetal Macrosomia

Diseases related to Fetal Macrosomia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
id Related Disease Score Top Affiliating Genes
1 perlman syndrome 11.1
2 gestational diabetes 10.4
3 intellectual disability-developmental delay-contractures syndrome 10.3 INS INSR
4 ehlers-danlos/osteogenesis imperfecta syndrome 10.3 H19 IGF2
5 arena syndrome 10.3 APOA1 LCAT
6 toxin-mediated infectious botulism 10.3 H19 IGF2
7 hall-riggs mental retardation syndrome 10.3 H19 IGF2
8 epibulbar lipodermoid-preauricular appendage-polythelia syndrome 10.3 H19 IGF2
9 neutral lipid storage disease with myopathy 10.3 IGF2 INS
10 familial progressive cardiac conduction defect 10.3 APOA1 LCAT
11 tyrosinemia, type ii 10.2 APOA1 LCAT
12 breast fibroadenoma 10.2 IGF2 INS
13 diabetic cataract 10.2 IGF2 INS INSR
14 albinism, oculocutaneous, type v 10.2 APOA1 APOB
15 joint disorders 10.2 APOA1 APOB INS
16 primary pigmented nodular adrenocortical disease 10.2 APOA1 APOB INS
17 dentinogenesis imperfecta type 2 10.2 APOB LCAT
18 bleeding disorder, east texas type 10.2 APOA1 APOB INS
19 sohval soffer syndrome 10.2 IGF1 IGFBP3
20 brucella canis brucellosis 10.2 IGF1 IGF2 INS
21 femur bifid with monodactylous ectrodactyly 10.2 IGF1 IGF2 INSR
22 bird fancier's lung 10.2 APOA1 APOB LCAT
23 pelvic muscle wasting 10.2 IGF1 INS INSR
24 stone in bladder diverticulum 10.2 APOA1 APOB LCAT
25 obesity 10.2
26 immunodeficiency 18 10.2 APOA1 APOB INS
27 malignant ovarian mixed epithelial neoplasm 10.2 APOA1 H19 IGF2
28 von willebrand disease, platelet-type 10.2 APOA1 APOB LCAT
29 posterior uveal melanoma 10.2 APOA1 APOB INS
30 neuropathy, hereditary sensory and autonomic, type ia 10.2 APOA1 APOB LCAT
31 hypertriglyceridemia 10.2 APOA1 APOB LCAT
32 cataract 5, multiple types 10.1 APOA1 APOB LCAT
33 cervix small cell carcinoma 10.1 APOA1 APOB INS
34 protein s deficiency 10.1 IGF1 IGFBP3 INS
35 epileptic encephalopathy, early infantile, 24 10.1 IGF1 IGF2 IGFBP3
36 chondrocalcinosis with early-onset osteoarthritis 10.1 APOA1 APOB INS LCAT
37 cervix squamous papilloma 10.1 IGF1 IGFBP3 INS
38 acute apical periodontitis 10.1 APOA1 APOB INS LCAT
39 narcolepsy 6 10.1 APOA1 APOB INS LCAT
40 seow najjar syndrome 10.0 IGF1 IGFBP3 INS PGM1
41 macular degeneration, age-related, 12 10.0 APOA1 APOB INS LCAT
42 mannosidosis, beta 10.0 APOA1 APOB IGF1 LCAT
43 microtia, hearing impairment, and cleft palate 10.0 IGF1 IGFBP3
44 myelophthisic anemia 10.0 APOA1 APOB INS
45 gerstmann syndrome 10.0 IGF1 IGF2 IGFBP3 INS
46 diarrhea 3, secretory sodium, congenital, syndromic 10.0 IGF1 IGFBP3 INS INSR
47 hyperinsulinemic hypoglycemia, familial, 5 10.0 IGF1 IGFBP3 INS INSR
48 thrombophilia 10.0 IGF1 IGF2 IGFBP3 INS
49 leg dermatosis 10.0 INS INSR LEP
50 spondylometaphyseal dysplasia, megarbane-dagher-melike type 10.0 IGF1 IGFBP3

Graphical network of the top 20 diseases related to Fetal Macrosomia:



Diseases related to Fetal Macrosomia

Symptoms & Phenotypes for Fetal Macrosomia

MGI Mouse Phenotypes related to Fetal Macrosomia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.15 APOA1 APOB APOM IGF1 IGF2 IGFBP3
2 cardiovascular system MP:0005385 10.09 APOA1 APOB IGF1 IGF2 INS INSR
3 endocrine/exocrine gland MP:0005379 10.06 OXT APOA1 IGF1 IGF2 IGFBP3 INS
4 adipose tissue MP:0005375 9.93 LEP OXT IGF1 IGFBP3 INS INSR
5 integument MP:0010771 9.87 APOA1 IGF1 IGF2 IGFBP3 INS LEP
6 liver/biliary system MP:0005370 9.86 APOA1 APOB IGF2 IGFBP3 INS INSR
7 muscle MP:0005369 9.7 APOB IGF1 IGF2 IGFBP3 INS INSR
8 renal/urinary system MP:0005367 9.5 IGF1 IGF2 INS INSR LCAT LEP
9 reproductive system MP:0005389 9.28 APOB APOM IGF1 IGF2 INS INSR

Drugs & Therapeutics for Fetal Macrosomia

Drugs for Fetal Macrosomia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glyburide Approved Phase 4,Phase 3,Phase 2 10238-21-8 3488
2
Metformin Approved Phase 4,Phase 2,Phase 3 657-24-9 14219 4091
3
Zinc Approved Phase 4,Phase 3 7440-66-6 32051 23994
4 Hypoglycemic Agents Phase 4,Phase 2,Phase 3
5 insulin Phase 4,Phase 3,Phase 2
6 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2
7
Diazoxide Approved Phase 2, Phase 3 364-98-7 3019
8 Antihypertensive Agents Phase 2, Phase 3
9 Vasodilator Agents Phase 2, Phase 3
10 Gastrointestinal Agents Phase 2
11 glucagon Phase 2
12 Glucagon-Like Peptide 1 Phase 2
13 Hormone Antagonists Phase 2
14 Hormones Phase 2,Early Phase 1
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
16 Incretins Phase 2
17
Benzocaine Approved 1994-09-7, 94-09-7 2337
18
Insulin Aspart Approved 116094-23-6 16132418
19
Epinephrine Approved, Vet_approved 51-43-4 5816
20
Insulin Detemir Approved 169148-63-4 5311023
21
Insulin Glargine Approved 160337-95-1
22
Insulin Lispro Approved 133107-64-9
23
Oxytocin Approved, Vet_approved 50-56-6 439302 53477758
24
Zinc oxide Approved 1314-13-2
25
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
26
leucovorin Approved, Nutraceutical 58-05-9 54575, 6560146 143
27 tannic acid Approved, Nutraceutical
28
Cholecalciferol Approved, Nutraceutical 67-97-0 6221 10883523 5280795
29
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
30 Mitogens
31 Hematinics
32 Micronutrients
33 Trace Elements
34 Vitamin B Complex
35 Vitamins
36 Insulin, Isophane
37 Isophane insulin, beef
38 Isophane Insulin, Human
39 Adrenergic Agents
40 Adrenergic Agonists
41 Adrenergic alpha-Agonists
42 Adrenergic beta-Agonists
43 Anti-Asthmatic Agents
44 Autonomic Agents
45 Bronchodilator Agents
46 Epinephryl borate
47
Imidacloprid 105827-78-9 86418
48 Mydriatics
49 Neurotransmitter Agents
50 Peripheral Nervous System Agents

Interventional clinical trials:

(show top 50) (show all 110)
id Name Status NCT ID Phase
1 Oral Antidiabetic Agents in Pregnancy Unknown status NCT02091336 Phase 4
2 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4
3 DAME: Induction of Labor or Waiting for Suspicion Fetal Macrosomia Completed NCT00190320 Phase 4
4 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4
5 Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo Completed NCT00744965 Phase 4
6 Glyburide Compared to Insulin in the Management of White's Classification A2 Gestational Diabetes Withdrawn NCT00160485 Phase 4
7 Diazoxide In the Management Of Hypoglycemic Neonates Unknown status NCT00994149 Phase 2, Phase 3
8 Metformin in Obese Non-diabetic Pregnant Women Completed NCT01273584 Phase 2, Phase 3
9 Metformin in Women With Type 2 Diabetes in Pregnancy Trial Recruiting NCT01353391 Phase 3
10 Multicenter Randomized Trial of Non-inferiority Between Glyburide and Insulin for the Treatment of Gestational Diabetes Active, not recruiting NCT01731431 Phase 3
11 Effect of a Continuous Glucose Monitoring on Maternal and Neonatal Outcomes in Gestational Diabetes Mellitus Not yet recruiting NCT02838147 Phase 3
12 Pregnancy Outcomes: Effects of Metformin Study (POEM Study) Not yet recruiting NCT02947503 Phase 3
13 Home Versus Hospital Care in Glucose Monitoring of Gestational Diabetes and Mild Gestational Hyperglycemia Completed NCT01441518 Phase 2
14 Glucagon in the Treatment of Hypoglycemia in Newborn Infants of Diabetic Mothers Completed NCT00434772 Phase 2
15 Impact of Diet and Exercise Activity on Pregnancy Outcomes Recruiting NCT00486629 Phase 2
16 Antenatal Development Evaluated Prospectively Unknown status NCT02478554
17 Correlation Between Placental Thickness in the Second and Third Trimester and Fetal Weight Unknown status NCT02473991
18 Fish Oil Supplementation in Women With Gestational Diabetes Unknown status NCT02371343
19 Weight Gain During Pregnancy - a Randomized Controlled Trial of Intervention to Prevent Excessive Gestational Weight Gain Unknown status NCT00451425
20 Predictors of Maternal Weight Gain and Neonatal Body Composition Unknown status NCT00634764
21 Frequency of Blood Glucose Monitoring in Patients With Gestational Diabetes Unknown status NCT01818557
22 Postprandial Walking in Obese Pregnant Women and Perinatal Outcomes - a Multicenter Randomized Clinical Trial Unknown status NCT02180152
23 Effect of Psycho-education on Gestational Weight Gain and Anxiety/Depression in Obese Pregnant Women Unknown status NCT01329835
24 Vaspin Levels Compared With Serum Insulin and Blood Glucose Levels in Neonates Unknown status NCT01363622
25 Inositol Stereoisomers to Treat Gestational Diabetes Unknown status NCT02097069
26 Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes Unknown status NCT00678080
27 Managing Diabetes During Pregnancy in the Wireless Age Unknown status NCT01474525
28 The Role of Umbilical Cord Thickness in Prediction of Fetal Macrosomia in Patients With Gestational Diabetes Mellitus Completed NCT02643225
29 The DNA Methylation of ARHGEF11 in Macrosomia Completed NCT03165643
30 Breast Milk Zinc Transfer to Appropriate- and Small-for-gestational-age Bangladeshi Infants Completed NCT01728766
31 Treatment of Impaired Glucose Tolerance in Pregnancy Completed NCT00625781
32 Lifestyle Intervention and Prevention of Gestational Diabetes Mellitus Completed NCT02368600
33 Exploration of the Lipid Metabolism During the Diabetic Pregnancies Completed NCT00639964
34 Randomized Translational Study to Examine the Effects of Shared Care in Management of Gestational Diabetes Completed NCT01565564
35 Weight Management for Improved Pregnancy Outcomes Completed NCT00950235
36 Exercise Training in Pregnancy for Obese Mothers Completed NCT01243554
37 Myo-inositol in Obese Pregnant Women Completed NCT01047982
38 Fructosamines and Gestational Diabetes (FRUCTO) Completed NCT02159378
39 Dietary and Lifestyle Interventions in Obese Pregnant Women Completed NCT02095028
40 Improving Outcomes in Underserved Women With GDM Completed NCT00774124
41 Fetal Growth Evaluation by Three-Dimensional Ultrasound Completed NCT00340171
42 Maternal Obesity and Small for Gestational Age Infants Completed NCT00371657
43 Preventing Childhood Obesity: A Two-pronged Approach Starting in Pregnancy and the First Year Postpartum Completed NCT01129505
44 Adipocytokines, Gestational Diabetes Mellitus and Lipid Metabolism Completed NCT02378675
45 The Effect of Real-time Continuous Glucose Monitoring on Severe Complications to Pregnancy in Women With Diabetes Completed NCT00994357
46 Perinatal Outcomes in Nutritionally Monitored Obese Pregnant Women Completed NCT00740766
47 Prophylactic Dextrose Gel for Newborns at High-risk for Hypoglycemia Completed NCT02523222
48 Prediction of Fetal Lung Maturity Completed NCT03159234
49 Fitness Improvement in Obese, Pregnant Women: an Intervention Trial Completed NCT01610323
50 Metabolic Risk Following Gestational Diabetes Mellitus Completed NCT02133729

Search NIH Clinical Center for Fetal Macrosomia

Genetic Tests for Fetal Macrosomia

Anatomical Context for Fetal Macrosomia

MalaCards organs/tissues related to Fetal Macrosomia:

39
Testes, Placenta

Publications for Fetal Macrosomia

Articles related to Fetal Macrosomia:

(show top 50) (show all 193)
id Title Authors Year
1
Vacuum extraction in fetal macrosomia and risk of neonatal complications: a population-based cohort study. ( 27472147 )
2016
2
Induction of labour for fetal macrosomia: do we finally have an answer? ( 27921388 )
2016
3
Risk factors and outcomes of fetal macrosomia in a tertiary centre in Tanzania: a case-control study. ( 27557930 )
2016
4
Peptidome profiling of umbilical cord plasma associated with gestational diabetes-induced fetal macrosomia. ( 26945739 )
2016
5
Induction of labour at or near term for suspected fetal macrosomia. ( 27208913 )
2016
6
Amniotic fluid index and estimated fetal weight for prediction of fetal macrosomia: a prospective observational study. ( 27596358 )
2016
7
Gestational diabetes: Glycaemic predictors for fetal macrosomia and maternal risk of future diabetes. ( 26818892 )
2016
8
Fetal macrosomia as a risk factor for shoulder dystocia during vacuum extraction. ( 27549142 )
2016
9
Practice Bulletin No. 173 Summary: Fetal Macrosomia. ( 27776066 )
2016
10
Induction of labour for suspected fetal macrosomia, Boulvain et al (2016). ( 27652444 )
2016
11
Practice Bulletin No. 173: Fetal Macrosomia. ( 27776071 )
2016
12
Comparison of 2- and 3-Dimensional Sonography for Estimation of Birth Weight and Neonatal Adiposity in the Setting of Suspected Fetal Macrosomia. ( 27091915 )
2016
13
Fetal macrosomia: induction of labour or expectant management? ( 26595636 )
2015
14
Fetal macrosomia: induction of labour or expectant management? - Authors' reply. ( 26595634 )
2015
15
Determinants and outcome of fetal macrosomia in a Nigerian tertiary hospital. ( 26903699 )
2015
16
Fetal macrosomia: induction of labour or expectant management? ( 26595633 )
2015
17
Effect of Personalized Nutrition Guidance on the Birth Rate of Fetal Macrosomia in Chinese Population: A Meta-analysis of Nine Randomized Controlled Trials. ( 27352186 )
2015
18
Cord blood copeptin concentrations in fetal macrosomia. ( 26477270 )
2015
19
Low cord blood serum levels of vitamin D: cause or effect of fetal macrosomia? ( 26411220 )
2015
20
Weight gain in pregnancy, maternal age and gestational age in relation to fetal macrosomia. ( 25954731 )
2015
21
Does fetal macrosomia affect umbilical artery Doppler velocity waveforms in pregnancies complicated by gestational diabetes? ( 26699801 )
2015
22
The Effects of Prepregnancy Body Mass Index and Gestational Weight Gain on Fetal Macrosomia Among American Indian/Alaska Native Women. ( 26122253 )
2015
23
Fetal macrosomia: induction of labour or expectant management? ( 26595635 )
2015
24
An Evidence-Based Approach to Defining Fetal Macrosomia. ( 26499356 )
2015
25
Fetal macrosomia: a problem in need of a policy. ( 24395685 )
2014
26
Maternal obesity and occurrence of fetal macrosomia: a systematic review and meta-analysis. ( 25544943 )
2014
27
Physical activity, sedentary behaviour and fetal macrosomia in uncomplicated pregnancies: A prospective cohort study. ( 24861673 )
2014
28
The combined effect of maternal obesity and fetal macrosomia on pregnancy outcomes. ( 25222356 )
2014
29
Sonographic weight estimation in fetal macrosomia: influence of the time interval between estimation and delivery. ( 25534163 )
2014
30
Counseling for Fetal Macrosomia: An Estimated Fetal Weight of 4,000a88g is Excessively Low. ( 24839149 )
2014
31
Third trimester insulin levels are not correlated with fetal macrosomia or delivery complications. ( 24937972 )
2014
32
Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes. ( 25231897 )
2014
33
Increased mRNA levels of apolipoprotein M and apolipoprotein AI in the placental tissues with fetal macrosomia. ( 25194312 )
2014
34
Amniotic fluid insulin and C-peptide as predictive markers for fetal macrosomia, birth injuries, and delivery complications? ( 24423633 )
2014
35
Estimate of fetal weight by ultrasound within two weeks of delivery in the detection of fetal macrosomia. ( 24773582 )
2014
36
Differential expression of circulating miRNAs in maternal plasma in pregnancies with fetal macrosomia. ( 25370776 )
2014
37
Women's perceptions and experiences of fetal macrosomia. ( 23786991 )
2013
38
Significance of neonatal body indices in identifying fetal macrosomia. ( 22652563 )
2013
39
Prenatal detection and consequences of fetal macrosomia. ( 23221275 )
2013
40
Fetal macrosomia and shoulder dystocia in women with gestational diabetes: risks amenable to treatment? ( 23076441 )
2013
41
Fetal macrosomia: risk factors, maternal, and perinatal outcome. ( 24380006 )
2013
42
Adverse maternal outcomes associated with fetal macrosomia: what are the risk factors beyond birthweight? ( 23565692 )
2013
43
Following the 2009 American Institute of Medicine recommendations for normal body mass index and overweight women led to an increased risk of fetal macrosomia among Taiwanese women. ( 24075370 )
2013
44
Fetal macrosomia in Japanese women. ( 23279000 )
2013
45
Is fetal macrosomia related to blood pressure among adolescents? A birth cohort study in China. ( 23595162 )
2013
46
Prediction of fetal macrosomia with ultrasound parameters and maternal glycemic controls in gestational diabetes mellitus. ( 23444756 )
2012
47
Metformin is not significantly different from insulin for preventing fetal macrosomia in women with gestational diabetes. ( 21937503 )
2012
48
Increased composite maternal and neonatal morbidity associated with ultrasonographically suspected fetal macrosomia. ( 22439605 )
2012
49
Is prenatal identification of fetal macrosomia useful? ( 22326615 )
2012
50
Fetal and maternal outcomes in pregnancies complicated with fetal macrosomia. ( 22754881 )
2012

Variations for Fetal Macrosomia

Expression for Fetal Macrosomia

Search GEO for disease gene expression data for Fetal Macrosomia.

Pathways for Fetal Macrosomia

Pathways related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.46 APOA1 APOB APOM SLC2A3
2
Show member pathways
12.17 IGF1 INS INSR LEP
3
Show member pathways
12.04 APOA1 APOB INS INSR
4
Show member pathways
11.84 IGF1 INS INSR
5 11.81 IGF1 INS LEP
6 11.7 IGF1 IGFBP3 INS
7 11.65 IGF1 INS INSR
8
Show member pathways
11.44 APOA1 APOB LCAT
9 11.27 IGF1 IGF2 INS
10 11.24 IGF1 IGFBP3 INS LEP
11 11.2 IGF1 INS INSR
12 11.13 INS INSR LEP
13 10.94 APOA1 APOB
14 10.9 IGF1 INS INSR
15 10.88 INSR LEP
16 10.12 IGF1 IGF2 IGFBP3

GO Terms for Fetal Macrosomia

Cellular components related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.81 APOA1 APOB IGFBP3 INS
2 extracellular region GO:0005576 9.7 APOA1 APOB APOM IGF1 IGF2 IGFBP3
3 endosome lumen GO:0031904 9.55 APOB INS
4 endocytic vesicle lumen GO:0071682 9.54 APOA1 APOB
5 chylomicron GO:0042627 9.52 APOA1 APOB
6 high-density lipoprotein particle GO:0034364 9.5 APOA1 APOM LCAT
7 spherical high-density lipoprotein particle GO:0034366 9.48 APOA1 APOM
8 intermediate-density lipoprotein particle GO:0034363 9.46 APOA1 APOB
9 insulin-like growth factor ternary complex GO:0042567 9.43 IGF1 IGFBP3
10 very-low-density lipoprotein particle GO:0034361 9.43 APOA1 APOB APOM
11 insulin-like growth factor binding protein complex GO:0016942 9.4 IGF1 IGFBP3
12 discoidal high-density lipoprotein particle GO:0034365 9.37 APOA1 APOM
13 low-density lipoprotein particle GO:0034362 9.33 APOA1 APOB APOM
14 extracellular space GO:0005615 9.32 APOA1 APOB APOM IGF1 IGF2 IGFBP3
15 extracellular exosome GO:0070062 10.15 APOA1 APOB APOM IGF2 IGFBP3 INSR

Biological processes related to Fetal Macrosomia according to GeneCards Suite gene sharing:

(show all 40)
id Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.95 IGF2 INS INSR PGM1 SLC2A3
2 platelet degranulation GO:0002576 9.85 APOA1 IGF1 IGF2
3 lipid transport GO:0006869 9.85 APOA1 APOB APOM
4 steroid metabolic process GO:0008202 9.85 APOA1 APOB LCAT
5 glucose homeostasis GO:0042593 9.85 INS INSR LEP
6 response to estradiol GO:0032355 9.84 APOB LEP OXT
7 cholesterol metabolic process GO:0008203 9.84 APOA1 APOB LCAT LEP
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.83 IGF1 IGF2 INS
9 positive regulation of protein kinase B signaling GO:0051897 9.83 IGF2 INS INSR LEP
10 insulin receptor signaling pathway GO:0008286 9.82 IGF2 INS INSR
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.8 IGF1 INS LEP
12 retinoid metabolic process GO:0001523 9.8 APOA1 APOB APOM
13 glucose metabolic process GO:0006006 9.78 IGF2 INS LEP PGM1
14 positive regulation of DNA replication GO:0045740 9.77 IGF1 INS INSR
15 positive regulation of glucose import GO:0046326 9.76 IGF1 INS INSR
16 activation of protein kinase B activity GO:0032148 9.75 IGF1 INS INSR
17 cholesterol efflux GO:0033344 9.74 APOA1 APOB APOM
18 cholesterol transport GO:0030301 9.73 APOA1 APOB LCAT
19 cellular protein metabolic process GO:0044267 9.73 APOA1 APOB IGF1 IGF2 IGFBP3 INS
20 cholesterol homeostasis GO:0042632 9.71 APOA1 APOB APOM LCAT
21 reverse cholesterol transport GO:0043691 9.69 APOA1 APOM LCAT
22 adrenal gland development GO:0030325 9.68 APOA1 INSR
23 high-density lipoprotein particle remodeling GO:0034375 9.67 APOA1 APOM LCAT
24 lipoprotein metabolic process GO:0042157 9.67 APOA1 APOB APOM LCAT
25 high-density lipoprotein particle assembly GO:0034380 9.66 APOA1 APOM
26 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.66 IGF1 IGFBP3
27 chylomicron assembly GO:0034378 9.65 APOA1 APOB
28 chylomicron remodeling GO:0034371 9.64 APOA1 APOB
29 high-density lipoprotein particle clearance GO:0034384 9.64 APOA1 APOM
30 positive regulation of glycolytic process GO:0045821 9.63 IGF1 INS INSR
31 positive regulation of respiratory burst GO:0060267 9.62 INS INSR
32 positive regulation of developmental growth GO:0048639 9.61 INSR LEP
33 bone mineralization involved in bone maturation GO:0035630 9.61 IGF1 LEP
34 positive regulation of insulin receptor signaling pathway GO:0046628 9.61 IGF2 INS LEP
35 regulation of intestinal cholesterol absorption GO:0030300 9.6 APOA1 LEP
36 lipoprotein biosynthetic process GO:0042158 9.5 APOA1 APOB LCAT
37 positive regulation of mitotic nuclear division GO:0045840 9.46 IGF1 IGF2 INS INSR
38 positive regulation of glycogen biosynthetic process GO:0045725 9.26 IGF1 IGF2 INS INSR
39 positive regulation of MAPK cascade GO:0043410 9.1 IGF1 IGF2 IGFBP3 INS INSR LEP
40 positive regulation of cell proliferation GO:0008284 10.03 IGF1 IGF2 INS INSR LEP

Molecular functions related to Fetal Macrosomia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.54 APOA1 APOB APOM
2 cholesterol transporter activity GO:0017127 9.43 APOA1 APOB
3 insulin receptor binding GO:0005158 9.43 IGF1 IGF2 INS
4 insulin-like growth factor I binding GO:0031994 9.4 IGFBP3 INSR
5 hormone activity GO:0005179 9.35 IGF1 IGF2 INS LEP OXT
6 lipid transporter activity GO:0005319 9.33 APOA1 APOB APOM
7 insulin-like growth factor II binding GO:0031995 9.32 IGFBP3 INSR
8 insulin-like growth factor receptor binding GO:0005159 8.92 IGF1 IGF2 INS INSR

Sources for Fetal Macrosomia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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