MCID: FTL030
MIFTS: 19

Fetal Valproate Syndrome malady

Fetal diseases category

Summaries for Fetal Valproate Syndrome

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Sources:
42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Fetal valproate syndrome occurs when a baby develops signs and symptoms as a result of an exposure to valproic acid during fetal development.  fetal exposure to valproic acid is associated with 2 to 3 times the general population risk for birth defects.  this results in roughly a 6 to 9% risk of having a child with a birth defect versus the general population risk of 2 to 3%.  some children with this syndrome share common subtle facial characteristics, including thin arched eyebrows that may be spaced far apart, a wide nasal bridge, short nose with anteverted nostrils, thin upper lip, and smooth long philtrum (space between nose and lip). these features may become less prominent with time. fetal valproate syndrome may also be associated with a wide range of other birth defects, as well as intellectual disability. in most cases the risks for a particular symptom or defect is not currently known. last updated: 3/5/2010

MalaCards: Fetal Valproate Syndrome, also known as embryofoetal valproic acid syndrome, is related to coloboma and polydactyly, and has symptoms including short/small nose, long philtrum and epicanthic folds.

Wikipedia:63 Valproic acid (VPA, valproate), an acidic chemical compound, has found clinical use as an anticonvulsant... more...

Description from OMIM:46 609442

Aliases & Classifications for Fetal Valproate Syndrome

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Sources:
42NIH Rare Diseases, 48Orphanet, 46OMIM, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


Characteristics (Orphanet epidemiological data):

48
fetal valproate syndrome:
Inheritance: Sporadic; Age of onset: Neonatal/infancy


Aliases & Descriptions:

fetal valproate syndrome 42 48 46 60
embryofoetal valproic acid syndrome 42
valproic acid fetal effects from 42
fetal valproic acid syndrome 48
valproic acid embryopathy 42


External Ids:

OMIM46 609442
MESH via Orphanet35 C536525
ICD10 via Orphanet26 Q86.8
SNOMED-CT via Orphanet57 17231009
UMLS via Orphanet61 C0236026

Related Diseases for Fetal Valproate Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Fetal Valproate Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1coloboma10.1
2polydactyly10.1
3patent ductus arteriosus10.1
4dry eye syndrome10.1

Clinical Features for Fetal Valproate Syndrome

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

609442

Symptoms:

48 (show all 9)
  • short/small nose
  • long philtrum
  • epicanthic folds
  • microstomia/little mouth
  • flattened nose
  • downturned mouth
  • thin/retracted lips
  • omphalocele/exomphalos
  • antenatal exposure : anticonvulsants

Drugs & Therapeutics for Fetal Valproate Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Fetal Valproate Syndrome

Search CenterWatch for Fetal Valproate Syndrome

Genetic Tests for Fetal Valproate Syndrome

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Anatomical Context for Fetal Valproate Syndrome

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Animal Models for Fetal Valproate Syndrome or affiliated genes

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Publications for Fetal Valproate Syndrome

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Genetic Variations for Fetal Valproate Syndrome

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Expression for genes affiliated with Fetal Valproate Syndrome

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Sources:
15Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Fetal Valproate Syndrome.

Pathways for genes affiliated with Fetal Valproate Syndrome

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Compounds for genes affiliated with Fetal Valproate Syndrome

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GO Terms for genes affiliated with Fetal Valproate Syndrome

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Products for genes affiliated with Fetal Valproate Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fetal Valproate Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet